Rebecca J Moon, Stefania D'Angelo, Sarah R Crozier, Elizabeth M Curtis, Michelle Fernandes, Alexandra J Kermack, Justin H Davies, Keith M Godfrey, Nicholas J Bishop, Stephen H Kennedy, Ann Prentice, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Hazel M Inskip, Muhammad Kassim Javaid, Aris T Papageorghiou, Cyrus Cooper, Nicholas C Harvey
BACKGROUND: Observational studies relating maternal 25-hydroxyvitamin D status to timing and mode of delivery have reported inconsistent results. We assessed the effect of antenatal cholecalciferol supplementation on the incidence of preterm birth, delivery mode and post-partum haemorrhage (PPH). METHODS: MAVIDOS was a randomized, double-blind, placebo-controlled trial of 1000 IU/day cholecalciferol from 14 weeks' gestation until delivery. Gestational age, mode of delivery [categorized as spontaneous vaginal delivery (SVD), instrumental (including forceps and vacuum extraction) or Caesarean section] and PPH (>500 ml estimated blood loss) were determined from medical records...
December 28, 2022: Journal of Public Health