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https://www.readbyqxmd.com/read/28805196/-the-evaluation-of-color-vision-and-its-diagnostic-value-in-predicting-the-risk-of-diabetic-retinopathy-in-patients-with-glucose-metabolism-disorders
#1
Katarzyna Jończyk-Skórka, Jan Kowalski
AIM: The aim of the study was to evaluate color vision and its diagnostic value in predicting the risk of diabetic retinopathy in patients with glucose metabolism disorders. MATERIALS AND METHODS: The study involved 197 people, 92 women and 105 men aged 63.21 ± 8.74 years. In order to assess glucose metabolism disorders, patients were divided into three groups. The first group (DM) consisted of 60 people (16 women and 44 men aged 61.92 ± 8.46 years). These were people with type 2 diabetes...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28804816/preanalytical-issues-in-hemostasis-and-thrombosis-testing
#2
Giuseppe Lippi, Emmanuel J Favaloro
Hemostasis testing is critical to many hemorrhagic and thrombotic disorders, wherein laboratory diagnostics can provide critical information for diagnosis, prognostication, and therapeutic monitoring. Due to this crucial role in modern medicine, hemostasis tests should be carried out at their highest degree of quality, thus encompassing standardization and monitoring of all phases of the testing process. It is now clearly established that the preanalytical phase is the most critical and vulnerable part of the total testing process, since up to 70% of diagnostic errors are due to highly manual activities encompassing patient preparation and collection of biological samples, as well as handling, transportation, preparation and storage of blood specimens...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28796637/the-use-of-error-and-uncertainty-methods-in-the-medical-laboratory
#3
Wytze P Oosterhuis, Hassan Bayat, David Armbruster, Abdurrahman Coskun, Kathleen P Freeman, Anders Kallner, David Koch, Finlay Mackenzie, Gabriel Migliarino, Matthias Orth, Sverre Sandberg, Marit S Sylte, Sten Westgard, Elvar Theodorsson
Error methods - compared with uncertainty methods - offer simpler, more intuitive and practical procedures for calculating measurement uncertainty and conducting quality assurance in laboratory medicine. However, uncertainty methods are preferred in other fields of science as reflected by the guide to the expression of uncertainty in measurement. When laboratory results are used for supporting medical diagnoses, the total uncertainty consists only partially of analytical variation. Biological variation, pre- and postanalytical variation all need to be included...
August 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28796277/talking-the-talk-but-not-walking-the-walk-rt-qpcr-as-a-paradigm-for-the-lack-of-reproducibility-in-molecular-research
#4
REVIEW
Stephen Bustin, Tania Nolan
Poorly executed and inadequately reported molecular measurement methods are amongst the causes underlying the lack of reproducibility of much biomedical research. Although several high impact factor journals have acknowledged their past failure to scrutinise adequately the technical soundness of manuscripts, there is a perplexing reluctance to implement basic corrective measures. The reverse transcription real time quantitative PCR (RT-qPCR) is probably the most straightforward measurement technique available for RNA quantification and is widely used in research, diagnostic, forensic and biotechnology applications...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28794243/malpractice-claims-related-to-diagnostic-errors-in-the-hospital
#5
Ashwin Gupta, Ashley Snyder, Allen Kachalia, Scott Flanders, Sanjay Saint, Vineet Chopra
BACKGROUND: Little is known about the incidence or significance of diagnostic error in the inpatient setting. We used a malpractice claims database to examine incidence, predictors and consequences of diagnosis-related paid malpractice claims in hospitalised patients. METHODS: The US National Practitioner Database was used to identify paid malpractice claims occurring between 1 January 1999 and 31 December 2011. Patient and provider characteristics associated with paid claims were analysed using descriptive statistics...
August 9, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28794137/discrepant-measurements-of-maximal-left-ventricular-wall-thickness-between-cardiac-magnetic-resonance-imaging-and-echocardiography-in-patients-with-hypertrophic-cardiomyopathy
#6
Waseem Hindieh, Adaya Weissler-Snir, Helene Hammer, Arnon Adler, Harry Rakowski, Raymond H Chan
BACKGROUND: We sought to compare maximal left ventricular (LV) wall thickness (WT) measurements as obtained by routine clinical practice between echocardiography and cardiac magnetic resonance (CMR) and document causes of discrepancy. METHODS AND RESULTS: One-hundred and ninety-five patients with hypertrophic cardiomyopathy (median age, 52.8±15.1 years) who underwent echocardiography and CMR imaging within 6 months (median, 41 days; interquartile range, 16-97 days) were included...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28789802/fatalities-from-a-greek-burn-unit-a-clinicopathological-correlation-of-129-cases
#7
Myron Tsagkarakis, Georgia-Alexandra Spyropoulou, Leonidas Pavlidis, Othon Kritikos, Nikolaos Karakoukis, Evgenia Kyriopoulos, Dimosthenis Tsoutsos
INTRODUCTION: This is a retrospective study of the hospital data and autopsy reports of burn patients who died in the Burn Unit of the Department of Plastic and Reconstructive Surgery, Microsurgery and Burn Center of "G. Gennimatas" Hospital of Athens, Greece during the period 1999-2005. MATERIALS AND METHODS: The records of the burn victims deceased during the period 1999-2005 were reviewed and the cause of injury, percentage of body surface area (BSA) burned, age, gender, and co-morbidities were documented...
August 5, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28789685/remote-monitoring-of-cardiorespiratory-signals-from-a-hovering-unmanned-aerial-vehicle
#8
Ali Al-Naji, Asanka G Perera, Javaan Chahl
BACKGROUND: Remote physiological measurement might be very useful for biomedical diagnostics and monitoring. This study presents an efficient method for remotely measuring heart rate and respiratory rate from video captured by a hovering unmanned aerial vehicle (UVA). The proposed method estimates heart rate and respiratory rate based on the acquired signals obtained from video-photoplethysmography that are synchronous with cardiorespiratory activity. METHODS: Since the PPG signal is highly affected by the noise variations (illumination variations, subject's motions and camera movement), we have used advanced signal processing techniques, including complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and canonical correlation analysis (CCA) to remove noise under these assumptions...
August 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28782058/consistency-of-brca1-and-brca2-variant-classifications-among-clinical-diagnostic-laboratories
#9
Stephen E Lincoln, Shan Yang, Melissa S Cline, Yuya Kobayashi, Can Zhang, Scott Topper, David Haussler, Benedict Paten, Robert L Nussbaum
BACKGROUND: Genetic tests of the cancer predisposition genes BRCA1 and BRCA2 inform significant clinical decisions for both physicians and patients. Most uncovered variants are benign, and determining which few are pathogenic (disease-causing) is sometimes challenging and can potentially be inconsistent among laboratories. The ClinVar database makes de-identified clinical variant classifications from multiple laboratories publicly available for comparison and review, per recommendations of the American Medical Association (AMA), the American College of Medical Genetics (ACMG), the National Society for Genetic Counselors (NSGC), and other organizations...
July 2017: JCO Precis Oncol
https://www.readbyqxmd.com/read/28781756/tiddit-an-efficient-and-comprehensive-structural-variant-caller-for-massive-parallel-sequencing-data
#10
Jesper Eisfeldt, Francesco Vezzi, Pall Olason, Daniel Nilsson, Anna Lindstrand
Reliable detection of large structural variation ( > 1000 bp) is important in both rare and common genetic disorders. Whole genome sequencing (WGS) is a technology that may be used to identify a large proportion of the genomic structural variants (SVs) in an individual in a single experiment. Even though SV callers have been extensively used in research to detect mutations, the potential usage of SV callers within routine clinical diagnostics is hindered by high computational costs, usage of non-standard output format, and limited support for the various sequencing platforms and libraries...
2017: F1000Research
https://www.readbyqxmd.com/read/28780844/-analysis-of-the-clinical-characteristics-and-efficacy-of-20-cases-of-extranodal-rosai-dorfman-disease-in-head-and-neck
#11
L Cui, C L Yue
Objective: To analyze the clinical characteristics and efficacy of extranodal Rosai-Dorfman disease in head and neck. Methods: Clinical and pathological features and follow-up of patients who were diagnosed as RDD at Beijing Tongren Hospital of Capital Medical University between May 2008 and November 2016 were analyzed retrospectively. Results: There were a total of 20 extranodal RDD patients in head and neck including 14 females and 6 males, aged from 27 to 86 years (mean 52.5 years). Nose (14 cases) and throat (5 cases) were most commonly involved organs and 5 patients had 2 or more organs involved...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28780705/a-viscoelastic-anisotropic-hyperelastic-constitutive-model-of-the-human-cornea
#12
Charles Whitford, Natalia V Movchan, Harald Studer, Ahmed Elsheikh
A constitutive model based on the continuum mechanics theory has been developed which represents interlamellar cohesion, regional variation of collagen fibril density, 3D anisotropy and both age-related viscoelastic and hyperelastic stiffening behaviour of the human cornea. Experimental data gathered from a number of previous studies on 48 ex vivo human cornea (inflation and shear tests) enabled calibration of the constitutive model by numerical analysis. Wide-angle X-ray scattering and electron microscopy provided measured data which quantify microstructural arrangements associated with stiffness...
August 5, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28776822/ripple-mapping-initial-multicenter-experience-of-an-intuitive-approach-to-overcoming-the-limitations-of-3d-activation-mapping
#13
Vishal Luther, Nuno Cortez-Dias, Luis Carpinteiro, João de Sousa, Richard Navaratnum Balasubramaniam, Sharad C Agarwal, David Farwell, Solomon Mark Sopher, Girish Babu, Richard Till, Nikki Jones, Stuart Tan, Anthony Chow, Martin Lowe, Jem Lane, Naveen Pappachan, Nick Wf Linton, Prapa Kanagaratnam
BACKGROUND: Ripple Mapping (RM) displays electrograms as moving bars over a 3D surface displaying bipolar voltage, and has shown in a single-center series to be effective for atrial tachycardia (AT) mapping without annotation of local activation time or window-of-interest assignment. We tested the reproducibility of these findings in operators naive to RM, using it for the first time in post ablation AT. METHODS: Maps were collected with multielectrode catheters and CARTO ConfiDENSE...
August 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28776549/label-free-detection-for-a-dna-methylation-assay-using-raman-spectroscopy
#14
Jeongho Kim, Hae Jeong Park, Jae Hyung Kim, Boksoon Chang, Hun-Kuk Park
BACKGROUND: DNA methylation has been suggested as a biomarker for early cancer detection and treatment. Varieties of technologies for detecting DNA methylation have been developed, but they are not sufficiently sensitive for use in diagnostic devices. The aim of this study was to determine the suitability of Raman spectroscopy for label-free detection of methylated DNA. METHODS: The methylated promoter regions of cancer-related genes cadherin 1 (CDH1) and retinoic acid receptor beta (RARB) served as target DNA sequences...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28771032/reliability-of-computerized-neurocognitive-tests-for-concussion-assessment-a-meta-analysis
#15
James L Farnsworth, Lucas Dargo, Brian G Ragan, Minsoo Kang
OBJECTIVE:   Although widely used, computerized neurocognitive tests (CNTs) have been criticized because of low reliability and poor sensitivity. A systematic review was published summarizing the reliability of Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) scores; however, this was limited to a single CNT. Expansion of the previous review to include additional CNTs and a meta-analysis is needed. Therefore, our purpose was to analyze reliability data for CNTs using meta-analysis and examine moderating factors that may influence reliability...
August 3, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28766503/could-biochemistry-lab-alert-for-low-alkaline-phosphatase-prompt-diagnosis-of-hypophosphatasia
#16
Asma Deeb, Elfatih Abubaker
OBJECTIVE: Hypophosphatasia (HPP) is an inborn error of metabolism with significant morbidity and mortality. Its presentation is non-specific leading to delay or missed diagnosis. Low ALP is a diagnostic test. Unlike high ALP, low level is commonly un-flagged by laboratories as abnormal. A new treatment has proved to be effective in HPP. We aim to study frequency of flagging of low ALP level by laboratory and the clinical manifestations of patients presenting with low ALP for a possible diagnosis of HPP...
August 2, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28765633/performance-measurement-of-intraoperative-systolic-arterial-pressure-to-predict-in-hospital-mortality-in-adult-liver-transplantation
#17
Hyung-Chul Lee, Ho-Geol Ryu, Chul-Woo Jung
Profound hypotension during liver transplantation is aggressively treated with vasopressors thus frequently unrevealed in a retrospective study. The relationship between concealed intraoperative hypotension and in-hospital mortality after liver transplantation was evaluated using performance measurement (PM) of systolic arterial pressure (SAP). Median performance error (MDPE), median absolute performance error (MDAPE), and wobble of SAP were calculated using preoperative SAP as the reference value, and prereperfusion and postreperfusion SAPs as measured values...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765408/when-laboratory-tests-can-mislead-even-when-they-appear-plausible
#18
Adel Aa Ismail
A laboratory test has three phases, pre-analytical, analytical and post-analytical. The purpose of this review is to highlight an issue concerning the analytical phase of one of the most widely deployed groups of in vitro diagnostic tests using a common technology - namely immunoassay.Immunoassay entails an inherently high error rate and, therefore, has the potential for inaccurate and misleading results susceptible to misinterpretation and/or diagnostic misapplication by clinicians. An approach based on Bayesian inference (without mathematics or equations) - illustrated by examples - is presented; this may help clinicians in discerning potentially erroneous results even when they appear plausible and not unreasonable...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28763159/examining-the-diagnostic-utility-of-the-dsm-5-ptsd-symptoms-among-male-and-female-returning-veterans
#19
Jonathan D Green, Anthony Annunziata, Sarah E Kleiman, Michelle J Bovin, Aaron M Harwell, Annie M L Fox, Shimrit K Black, Paula P Schnurr, Darren W Holowka, Raymond C Rosen, Terence M Keane, Brian P Marx
BACKGROUND: Posttraumatic stress disorder (PTSD) diagnostic criteria have been criticized for including symptoms that overlap with commonly comorbid disorders, which critics argue undermines the validity of the diagnosis and inflates psychiatric comorbidity rates. In response, the upcoming 11th edition of the International Classification of Diseases (ICD-11) will offer PTSD diagnostic criteria that are intended to promote diagnostic accuracy. However, diagnostic utility analyses have not yet assessed whether these criteria minimize diagnostic errors...
August 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28759737/differential-diagnosis-of-hepatopulmonary-syndrome-hps-portopulmonary-hypertension-pph-and-hereditary-hemorrhagic-telangiectasia-hht
#20
REVIEW
Inna Krynytska, Mariya Marushchak, Anna Mikolenko, Anzhela Bob, Iryna Smachylo, Ludmyla Radetska, Olga Sopel
Hepatopulmonary syndrome (HPS) is a severe complication of advanced liver disease associated with an extremely poor prognosis. HPS is diagnosed in 4-47% of patients with cirrhosis and in 15-20% of candidates for liver transplantation. In addition, severe hypoxia is associated with a high risk of complications of liver transplantation (a 30% chance during the first 90 days) and increases the gap between transplantation and improving arterial oxygenation. The pathogenesis of HPS is not fully understood, and no effective pharmacological treatment has been developed yet...
July 31, 2017: Bosnian Journal of Basic Medical Sciences
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