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https://www.readbyqxmd.com/read/29146719/can-arterial-spin-labeling-with-multiple-postlabeling-delays-predict-cerebrovascular-reserve
#1
H J Choi, C-H Sohn, S-H You, R-E Yoo, K M Kang, T J Yun, S H Choi, J-H Kim, W-S Cho, J E Kim
BACKGROUND AND PURPOSE: The effect of delayed transit time is the main source of error in the quantitative measurement of CBF in arterial spin-labeling. In the present study, we evaluated the usefulness of the transit time-corrected CBF and arterial transit time delay from multiple postlabeling delays arterial spin-labeling compared with basal/acetazolamide stress technetium Tc99m-hexamethylpropylene amineoxime (Tc99m-HMPAO) SPECT in predicting impairment in the cerebrovascular reserve...
November 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29146038/microbiological-monitoring-of-medical-devices-after-cleaning-disinfection-and-sterilisation
#2
Rosa María Blázquez-Garrido, Eva Cuchí-Burgos, Carmen Martín-Salas, Patricia Ruiz-Garbajosa
The use of reusable semi-critical devices has been extended in current medical practice for both diagnostic and therapeutic purposes. However, reuse of these instruments carries the risk of cross-transmission of microorganisms from one patient to another. The process of cleaning and disinfecting these devices is complex, long, expensive and very error-prone. This paper analyses the epidemiological aspects of infections associated with the reuse of semi-critical devices and the role of the Microbiology laboratory in monitoring the cleaning and disinfecting process through microbiological controls...
November 13, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29139026/structural-elucidation-of-novel-biomarkers-of-known-metabolic-disorders-based-on-multistage-fragmentation-mass-spectra
#3
Jan Václavík, Karlien L M Coene, Ivo Vrobel, Lukáš Najdekr, David Friedecký, Radana Karlíková, Lucie Mádrová, Aleksanteri Petsalo, Udo F H Engelke, Annemiek van Wegberg, Leo A J Kluijtmans, Tomáš Adam, Ron A Wevers
Specific diagnostic markers are the key to effective diagnosis and treatment of inborn errors of metabolism (IEM). Untargeted metabolomics allows for the identification of potential novel diagnostic biomarkers. Current separation techniques coupled to high-resolution mass spectrometry provide a powerful tool for structural elucidation of unknown compounds in complex biological matrices. This is a proof-of-concept study testing this methodology to determine the molecular structure of as yet uncharacterized m/z signals that were significantly increased in plasma samples from patients with phenylketonuria and 3-hydroxy-3-methylglutaryl-CoA lyase deficiency...
November 14, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29137680/correction-to-development-of-molecular-confirmation-tools-for-swift-and-easy-rabies-diagnostics
#4
Kore Schlottau, Conrad M Freuling, Thomas Müller, Martin Beer, Bernd Hoffmann
After publication of the article [1], it has been brought to our attention that an incorrect genetic sequence has been cited. On page 4, paragraph 1 the following sequence is cited "ATG GAT GCC GAC AAG ATT GTM TTY AAA GTY AAT A 3". This is an error and the correct sequence should be "GGG GGC TTT YCC TAG GGT KAT ACW GGG CTT T 3".
November 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/29136629/modified-alcohol-formalin-cell-block-technique-in-head-and-neck-pathology-diagnosis
#5
Karishma M Desai, Punnya V Angadi, Alka D Kale, Seema Hallikerimath
OBJECTIVES: Cell block preparation is a recognized technique in histopathological diagnosis. This technique aids in maintaining an intact architecture and reducing the diagnostic errors associated with fine-needle aspiration cytology. Numerous techniques have been put forth, but the need for an optimal technique for routine use in the laboratory still persists. The aim of our study was to establish a cell block technique which aids in the accurate diagnosis of head and neck pathology...
November 15, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29135992/internal-quality-assurance-in-diagnostic-microbiology-a-simple-approach-for-insightful-data
#6
Valentin Scherz, Christian Durussel, Gilbert Greub
Given the importance of microbiology results on patient care, high quality standards are expected. Internal quality assurance (IQA) could mitigate the limitations of internal quality control, competency assessment and external quality assurance, adding a longitudinal insight, including pre- and post-analytical steps. Here, we implemented an IQA program in our clinical microbiology facilities with blind resubmission of routine samples during 22 months. One-hundred-and-twenty-one out of 123 (98.4%) serological analyses and 112 out of 122 (91...
2017: PloS One
https://www.readbyqxmd.com/read/29135908/evaluation-of-a-novel-immunoassay-for-lacosamide-therapeutic-drug-monitoring-comparison-with-a-liquid-chromatography-mass-spectrometry-assay
#7
Annachiara DʼUrso, Tiziano Ricotta, Ugo de Grazia
BACKGROUND: Monitoring serum levels of lacosamide, other than to establish individualized reference ranges may be helpful in several settings, including patients with liver and/or kidney failure or settings that may result in altered pharmacokinetic characteristics and to assess patients' compliance with therapy. In this study, the EurekaOne liquid chromatography-mass spectrometry (LC-MS/MS) method (in use method) and the ARK immunoassay method (new method) for lacosamide monitoring were compared...
December 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29135152/-masks-of-urogenital-tuberculosis-as-the-cause-of-diagnostic-errors
#8
D P Kholtobin, E K Kulchavenya
Urogenital tuberculosis does not have pathognomonic symptoms, so diagnostic errors are quite common. This systematic review of literature was conducted to identify the causes and estimate the incidence of erroneous diagnoses. We critically evaluated some articles in which the authors describe observations of urogenital tuberculosis as rare and unusual because they never encountered this disease, but in fact that were typical manifestations of genitourinary tuberculosis. The authors analyzed and illustrated the features of urinary tuberculosis in patients with pulmonary tuberculosis, differential diagnosis of urogenital tuberculosis and kidney cancer and male genitourinary organs, described errors in the diagnosis of urethral, testicular, penile, prostatic and epididymal tuberculosis...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29134707/reproducibility-of-diagnostic-criteria-associated-with-atypical-breast-cytology
#9
J Weigner, I Zardawi, S Braye, P McElduff
OBJECTIVE: The aim of this project was to assess the interobserver and intraobserver variability when identifying cytological criteria, which were found to have a statistically significant association with C3 within a workplace environment. METHODS: Sixty C3 cases with known endpoints of malignant, benign proliferative or benign non-proliferative diagnoses were blindly and independently screened by seven experienced cytologists to identify previously reported statistically significant criteria associated with the C3 category...
November 14, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29132508/brain-death
#10
REVIEW
Mack Drake, Andrew Bernard, Eugene Hessel
Death determined by neurologic criteria, commonly referred to as "brain death," occurs when function of the entire brain ceases, including the brain stem. Diagnostic criteria for brain death are explicit but controversy exists regarding nuances of the evaluation and potential confounders of the examination. Hospitals and ICU teams should carefully consider which clinicians will perform brain death testing and should use standard processes, including checklists to prevent diagnostic errors. Proper diagnosis is essential because misdiagnosis can be catastrophic...
December 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29127385/characterization-of-the-optical-properties-of-turbid-media-by-supervised-learning-of-scattering-patterns
#11
Iman Hassaninia, Ramin Bostanabad, Wei Chen, Hooman Mohseni
Fabricated tissue phantoms are instrumental in optical in-vitro investigations concerning cancer diagnosis, therapeutic applications, and drug efficacy tests. We present a simple non-invasive computational technique that, when coupled with experiments, has the potential for characterization of a wide range of biological tissues. The fundamental idea of our approach is to find a supervised learner that links the scattering pattern of a turbid sample to its thickness and scattering parameters. Once found, this supervised learner is employed in an inverse optimization problem for estimating the scattering parameters of a sample given its thickness and scattering pattern...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126825/artificial-intelligence-in-medical-practice-the-question-to-the-answer
#12
REVIEW
D Douglas Miller, Eric W Brown
Computer science advances and ultra-fast computing speeds find artificial intelligence (AI) broadly benefitting modern society - forecasting weather, recognizing faces, detecting fraud, and deciphering genomics. AI's future role in medical practice remains an unanswered question. Machines (computers) learn to detect patterns not decipherable using biostatistics by processing massive datasets (big data) through layered mathematical models (algorithms). Correcting algorithm mistakes (training) adds to AI predictive model confidence...
November 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29124043/activities-of-daily-living-measured-by-the-harvard-automated-phone-task-track-with-cognitive-decline-over-time-in-non-demented-elderly
#13
Gad A Marshall, Sarah L Aghjayan, Maria Dekhtyar, Joseph J Locascio, Kamal Jethwani, Rebecca E Amariglio, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
Background: Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29122315/can-in-vivo-medial-gastrocnemius-muscle-tendon-unit-lengths-be-reliably-estimated-by-two-ultrasonography-methods-a-within-session-analysis
#14
Francesco Cenni, Simon-Henri Schless, Lynn Bar-On, Guy Molenaers, Anja Van Campenhout, Erwin Aertbeliën, Herman Bruyninckx, Britta Hanssen, Kaat Desloovere
A clinically feasible method to reliably estimate muscle-tendon unit (MTU) lengths could provide essential diagnostic and treatment planning information. A 3-D freehand ultrasound (3-DfUS) method was previously validated for extracting in vivo medial gastrocnemius (MG) lengths, although the processing time can be considered substantial for the clinical environment. This investigation analyzed a quicker and simpler method using the US transducer as a spatial pointer (US-PaP), where the within-session reliability of extracting the muscle-tendon unit (MTU) and tendon lengths are estimated...
November 6, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29121903/diagnostic-errors-by-medical-students-results-of-a-prospective-qualitative-study
#15
Leah T Braun, Laura Zwaan, Jan Kiesewetter, Martin R Fischer, Ralf Schmidmaier
BACKGROUND: Diagnostic errors occur frequently in daily clinical practice and put patients' safety at risk. There is an urgent need to improve education on clinical reasoning to reduce diagnostic errors. However, little is known about diagnostic errors of medical students. In this study, the nature of the causes of diagnostic errors made by medical students was analyzed. METHODS: In June 2016, 88 medical students worked on eight cases with the chief complaint dyspnea in a laboratory setting using an electronic learning platform, in summary 704 processed cases...
November 9, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29121326/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-1-the-predicted-poor-responder
#16
Theodora C van Tilborg, Helen L Torrance, Simone C Oudshoorn, Marinus J C Eijkemans, Carolien A M Koks, Harold R Verhoeve, Annemiek W Nap, Gabrielle J Scheffer, A Petra Manger, Benedictus C Schoot, Alexander V Sluijmer, Arie Verhoeff, Henk Groen, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans
STUDY QUESTION: Does an increased FSH dose result in higher cumulative live birth rates in women with a predicted poor ovarian response, apparent from a low antral follicle count (AFC), scheduled for IVF or ICSI? SUMMARY ANSWER: In women with a predicted poor ovarian response (AFC < 11) undergoing IVF/ICSI, an increased FSH dose (225/450 IU/day) does not improve cumulative live birth rates as compared to a standard dose (150 IU/day). WHAT IS KNOWN ALREADY: In women scheduled for IVF/ICSI, an ovarian reserve test (ORT) can predict ovarian response to stimulation...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29118163/assessment-of-cwd-prion-shedding-in-deer-saliva-with-occupancy-modeling
#17
Kristen A Davenport, Brittany A Mosher, Brian M Brost, Davin M Henderson, Nathaniel D Denkers, Amy V Nalls, Erin McNulty, Candace K Mathiason, Edward A Hoover
Detection of prions is difficult due to the peculiarity of the pathogen, which is a misfolded form of a normal protein. The specificity and sensitivity of detection methods are imperfect in complex samples, including excreta. Here, we combined optimized prion amplification procedures with a statistical method that accounts for false positive and false negative errors to test deer saliva for chronic wasting disease (CWD) prions. This approach enabled us to discriminate shedding of prions in saliva and detection of prions in saliva -- a distinction crucial to understanding the role of prion shedding in disease transmission and for diagnosis...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29118160/a-dental-radiography-checklist-as-a-tool-for-quality-improvement
#18
Monica Williamson Nenad, Colleen Halupa, Ann Eshenaur Spolarich, JoAnn R Gurenlian
Purpose: A checklist intervention was applied to the dental radiographic acquisition process to determine its effectiveness in improving the diagnostic value of bitewing images and reducing patient exposure to unnecessary radiation.Methods: A mixed-method, nonrandomized research design using two dental hygiene program cohorts (n=33) as control and intervention groups was used to assess the effect of a radiographic checklist on the number and type of radiographic imaging errors. The relationship between perceived value of the checklist and willingness to continue its use was examined and analyzed using descriptive statistics...
December 2016: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29116518/antibody-affinity-and-stability-maturation-by-error-prone-pcr
#19
Tobias Unkauf, Michael Hust, André Frenzel
Antibodies are the fastest growing class of pharmaceutical proteins and essential tools for research and diagnostics. Often antibodies do show a desirable specificity profile but lack sufficient affinity for the desired application. Here, we describe a method to increase the affinity of recombinant antibody fragments based on the construction of mutagenized phage display libraries.After the construction of a mutated antibody gene library by error-prone PCR, selection of high-affinity variants is either performed by panning in solution or on immobilized antigen with washing conditions optimized for off-rate-dependent selection...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29116512/magnetic-nanoparticle-based-semi-automated-panning-for-high-throughput-antibody-selection
#20
Angela Chiew Wen Ch'ng, Nurul Hamizah Binti Hamidon, Zoltán Konthur, Theam Soon Lim
The application of recombinant human antibodies is growing rapidly mainly in the field of diagnostics and therapeutics. To identify antibodies against a specific antigen, panning selection is carried out using different display technologies. Phage display technology remains the preferred platform due to its robustness and efficiency in biopanning experiments. There are both manual and semi-automated panning selections using polystyrene plastic, magnetic beads, and nitrocellulose as the immobilizing solid surface...
2018: Methods in Molecular Biology
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