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Kei Takahashi, Peter Halfmann, Masaaki Oyama, Hiroko Kozuka-Hata, Takeshi Noda, Yoshihiro Kawaoka
Ebola virus (EBOV) protein L (EBOL) acts as a viral RNA-dependent RNA polymerase. To better understand the mechanisms underlying the transcription and replication of the EBOV genome, we sought to identify cellular factors involved in these processes via their coimmunoprecipitation with EBOL and by mass spectrometry. Of 65 candidate proteins identified, we focused on DNA topoisomerase 1 (TOP1), which localizes to the nucleus and unwinds helical DNA. We found that in the presence of EBOL, TOP1 colocalizes and interacts with EBOL in the cytoplasm, where transcription and replication of the EBOV genome occur...
August 2013: Journal of Virology
Henk van den Berg, Raman Velayudhan, Antonietta Ebol, Ben H G Catbagan, Romulo Turingan, Marisol Tuso, Jeffrey Hii
BACKGROUND: Analysis is lacking on the management of vector control systems in disease-endemic countries with respect to the efficiency and sustainability of operations. METHODS: Three locations were selected, at the scale of province, municipality and barangay (i.e. village). Data on disease incidence, programme activities, and programme management were collected on-site through meetings and focus group discussions. RESULTS: Adaptation of disease control strategies to the epidemiological situation per barangay, through micro-stratification, brings gains in efficiency, but should be accompanied by further capacity building on local situational analysis for better selection and targeting of vector control interventions within the barangay...
2012: Malaria Journal
Ricardo Antônio Correia Lima, Alberto Schanaider, Maria Cristina Ebole Santana, Mariana Genuíno de Oliveira, Vera Luiza Capelozzi, Patricia Rieken Macedo Rocco
OBJECTIVE: To describe an experimental, unprecedented model that mimics the abdominal compartment syndrome (ACS). METHODS: twenty rats were randomly divided into four groups. To simulate ACS intra-abdominal hypertension (IAH) was induced by inserting cotton surgical dressing (Zobec ®), 15x15cm (intra-abdominal pressure constant and equal to 12 mmHg) associated with hypovolemia induced by withdrawing blood, keeping mean arterial pressure (MAP) around 60 mmHg (HYPO)...
November 2011: Revista do Colégio Brasileiro de Cirurgiões
Luiz Felipe M Prota, Roberta M Lassance, Tatiana Maron-Gutierrez, Raquel C Castiglione, Cristiane Souza Baez Garcia, Maria Cristina Ebole Santana, Jackson Souza-Menezes, Soraia C Abreu, Vivian Samoto, Marcelo Felipe Santiago, Vera Luiza Capelozzi, Christina Maeda Takiya, Patricia R M Rocco, Marcelo M Morales
The aim of this study was to test the hypothesis that bone marrow mononuclear cell (BMDMC) therapy led an improvement in lung mechanics and histology in endotoxin-induced lung injury. Twenty-four C57BL/6 mice were randomly divided into four groups (n = 6 each). In the acute lung injury (ALI) group, Escherichia coli lipopolysaccharide (LPS) was instilled intratracheally (40 μg, IT), and control (C) mice received saline (0.05 ml, IT). One hour after the administration of saline or LPS, BMDMC (2 × 10(7) cells) was intravenously injected...
2010: Cell Transplantation
José M Ricart, Inmaculada Esplugues, Montserrat Ebole, Miguel A Navarro, Miguel Hernández, María Carmen Muñoz
No abstract text is available yet for this article.
October 2005: Actas Dermo-sifiliográficas
M b Eboll, T Galeotti, O Dionisi, G Longhi, T Terranova
No abstract text is available yet for this article.
April 1976: Archives of Biochemistry and Biophysics
F Denis, Y Robin
No abstract text is available yet for this article.
1979: Dakar Médical
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