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Myeloperoxidase

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https://www.readbyqxmd.com/read/29453088/serum-matrix-metalloproteinase-8-tissue-inhibitor-of-metalloproteinase-and-myeloperoxidase-in-ischemic-stroke
#1
Frederick Palm, Pirkko J Pussinen, Anton Safer, Taina Tervahartiala, Timo Sorsa, Christian Urbanek, Heiko Becher, Armin J Grau
BACKGROUND AND AIMS: Matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO) may contribute to cerebral damage in acute ischemic stroke. We tested the hypothesis that levels of MPO, MMP-8 and the ratio between MMP-8 and its regulator, tissue inhibitor of metalloproteinase (TIMP-1), are increased in acute ischemic stroke and its etiologic subgroups and they correlate with stroke severity. METHODS: In a cross-sectional case-control study, serum concentrations of MMP-8, MPO and TIMP-1 were assessed within 24 h after admission in 470 first-ever ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population...
February 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29453087/interleukin-6-is-an-independent-predictor-of-progressive-atherosclerosis-in-the-carotid-artery-the-troms%C3%A3-study
#2
Agnethe Eltoft, Kjell Arne Arntzen, Tom Wilsgaard, Ellisiv B Mathiesen, Stein Harald Johnsen
BACKGROUND AND AIMS: Novel biomarkers are linked to cardiovascular disease (CVD). The aim of the present study was to investigate the association between 28 blood biomarkers and the formation and progression of carotid plaque. METHODS: In a nested case control study with 703 participants from the population based Tromsø Study, a large biomarker panel was measured in blood obtained at baseline. Carotid ultrasound was assessed both at baseline and at 6 years of follow-up...
February 7, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29452855/constituents-of-neutrophil-extracellular-traps-induce-in-vitro-collagen-formation-in-mare-endometrium
#3
Maria Rosa Rebordão, Ana Amaral, Karolina Lukasik, Anna Szóstek-Mioduchowska, Pedro Pinto-Bravo, António Galvão, Dariusz J Skarzynski, Graça Ferreira-Dias
Neutrophil extracellular traps (NETs) are DNA complexes carrying nuclear and cytoplasmic proteins, such as elastase (ELA), cathepsin-G (CAT) and myeloperoxidase (MPO). Mare endometrosis is a chronic degenerative process characterized by excessive collagen in endometrium. While NETs fight bacteria that cause endometritis, they may trigger endometrial fibrogenesis. The aim was to evaluate the in vitro effect of some NETs components on mare endometrial fibrogenesis and determine its relationship with histopathology or estrous cycle...
February 7, 2018: Theriogenology
https://www.readbyqxmd.com/read/29452186/lectin-obtained-from-the-red-seaweed-bryothamnion-triquetrum-secondary-structure-and-anti-inflammatory-activity-in-mice
#4
Thais Pontes Carvalho Fontenelle, Glauber Cruz Lima, Jacilane Ximenes Mesquita, José Luiz de Souza Lopes, Tarcísio Vieira de Brito, Francisco das Chagas Vieira Júnior, Adriano Bezerra Sales, Karoline Saboia Aragão, Marcellus Henrique Loiola Ponte Souza, André Luiz Dos Reis Barbosa, Ana Lúcia Ponte Freitas
Seaweeds are sources of biomolecules with biological activities and pharmacological potential - for example, lectins, a group of proteins that can bind reversibly to carbohydrates or compounds containing them. The aim of this study was to elucidate the structural properties of a lectin extracted from the red seaweed Bryothamnion triquetrum (BtL) and to investigate its anti-inflammatory activity in mice. The lectin was purified by precipitation with ammonium sulfate and ion-exchange chromatography. Its secondary structure and tryptophan (Trp) microenvironment were analyzed by circular dichroism spectroscopy and steady-state fluorescence spectroscopy, respectively...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29452086/ameliorative-effects-of-clonidine-on-ethanol-induced-kidney-injury-in-rats-potential-role-for-imidazoline-1-receptor
#5
Nesreen M I M Elkomy, Islam A A E-H Ibrahim, Shimaa M Elshazly, Hassan M El-Fayoumi
Chronic alcoholism is a risk factor for kidney injury. Clonidine is an α 2 -adrenergic receptor/imidazoline-1 receptor agonist that can reduce blood pressure and maintain renal functions. This study aims to investigate the possible ameliorative effects of clonidine on ethanol induced kidney injury and its mechanism of action. Kidney injury was induced in rats by adding ethanol to drinking water for eight weeks. Clonidine effects on kidney functions and histopathology were measured. Moreover, phentolamine (α-adrenergic receptor antagonist), efaroxan (imidazoline-1 receptor antagonist) and rilmenidine (imidazoline-1 receptor agonist) were used to clarify the role of imidazoline-1 receptor in mediating renal ameliorative effects...
February 13, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29447930/linked-help-from-bacterial-proteins-drives-autoantibody-production-in-small-vessel-vasculitis
#6
David B G Oliveira
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The recent finding that S. aureus produces proteins that bind tightly to and block the function of both PR3 and MPO suggests a mechanism for ANCA formation. The bacterial protein-autoantigen conjugate is recognised by B cells with ANCA specificity, internalised, and the bacterial protein processed and presented to T cells with specificity for bacterial peptides...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29446750/copaiba-oil-decreases-oxidative-stress-and-inflammation-but-not-colon-damage-in-rats-with-tnbs-induced-colitis
#7
Maiara Morseli Coelho Barbosa, Fernando Augusto Vicentini, Cristiane Vizioli Castro-Ghizoni, Osmar Alves Lameira, Anacharis Babeto Sa-Nakanishi, Livia Bracht, Rosane Marina Peralta, Maria Raquel Marçal Natali, Adelar Bracht, Jurandir Fernando Comar
BACKGROUND: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. OBJECTIVE: to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. METHODS: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS)...
February 14, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29445110/promising-biomarkers-of-environmental-enteric-dysfunction-a-prospective-cohort-study-in-pakistani-children
#8
Najeeha Talat Iqbal, Kamran Sadiq, Sana Syed, Tauseefullah Akhund, Fayyaz Umrani, Sheraz Ahmed, Mohammad Yawar Yakoob, Najeeb Rahman, Shahida Qureshi, Wenjun Xin, Jennie Z Ma, Molly Hughes, Syed Asad Ali
Environmental Enteric Dysfunction (EED), a syndrome characterized by chronic gut inflammation, contributes towards stunting and poor response to enteric vaccines in children in developing countries. In this study, we evaluated major putative biomarkers of EED using growth faltering as its clinical proxy. Newborns (n = 380) were enrolled and followed till 18 months with monthly anthropometry. Biomarkers associated with gut and systemic inflammation were assessed at 6 and 9 months. Linear mixed effects model was used to determine the associations of these biomarkers with growth faltering between birth and 18 months...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444934/bromofatty-aldehyde-derived-from-bromine-exposure-and-myeloperoxidase-and-eosinophil-peroxidase-modify-glutathione-and-protein
#9
Mark A Duerr, Elisa N D Palladino, Celine L Hartman, James A Lambert, Jacob D Franke, Carolyn J Albert, Sadis Matalon, Rakesh P Patel, Arne Slungaard, David A Ford
α-Chlorofatty aldehydes (α-ClFALD) and α-bromofatty aldehydes (α-BrFALD) are produced in activated neutrophils and eosinophils. This study investigated the ability of α-BrFALD and α-ClFALD to react with the thiols of GSH and protein cysteinyl residues. Initial studies showed 2-bromohexadecanal (2-BrHDA) and 2-chlorohexadecanal (2-ClHDA) react with GSH producing the same fatty aldehyde-GSH adduct (FALD-GSH). In both synthetic and cellular reactions, FALD-GSH production was more robust with 2-BrHDA compared to 2-ClHDA as precursor...
February 14, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29442525/comparative-analysis-of-mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-dental-pulp-as-sources-of-cell-therapy-for-zone-of-stasis-burns
#10
Ozan Luay Abbas, Orhan Özatik, Zeynep Burçin Gönen, Serdal Öğüt, Fikriye Yasemin Özatik, Hasan Salkın, Ahmet Musmul
INTRODUCTION: The implantation of mesenchymal stem cells (MSCs) has been shown to exert benefits for the survival of the zone-of-stasis. However, the clinical experience indicates the importance of selecting the right source and type of stem cells. Therefore, we planned the current study to perform a quantitative comparison of MSCs isolated from three different sources to provide information useful in selection of the optimal source and to see whether critical mechanisms are conserved between different populations...
February 14, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29441563/acute-myeloid-t-lymphoblastic-leukaemia-amtl-a-distinct-category-of-acute-leukaemias-with-common-pathogenesis-in-need-of-improved-therapy
#11
Alejandro Gutierrez, Alex Kentsis
Advances in the classification of acute leukaemias have led to improved outcomes for a substantial fraction of patients. However, chemotherapy resistance remains a major problem for specific subsets of acute leukaemias. Here, we propose that a molecularly distinct subtype of acute leukaemia with shared myeloid and T cell lymphoblastic features, which we term acute myeloid/T-lymphoblastic leukaemia (AMTL), is divided across 3 diagnostic categories owing to variable expression of markers deemed to be defining of myeloid and T-lymphoid lineages, such as myeloperoxidase and CD3...
February 14, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29439880/suppression-of-inducible-nitric-oxide-synthase-and-tumor-necrosis-factor-alpha-level-by-lycopene-is-comparable-to-methylprednisolone-in-acute-pancreatitis
#12
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Omnia B Hamada
BACKGROUND: Oxidative stress and inflammation may play a key role in the pathogenesis of acute pancreatitis (AP). Lycopene, a natural carotenoid, has antioxidant scavenger capacity and inhibits inflammation in many experimental models. AIM: The study was designed to investigate whether lycopene can ameliorate l-arginine-induced pancreatitis in rats and to elucidate the underlying molecular mechanisms of these effects. METHODS: Forty-eight adult male Wistar rats were divided into: control group (vehicle, orally, 10 days), AP group (3 g/kg l-arginine, single i...
February 2, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29438939/at-rvd1-repairs-mouse-lung-after-cigarette-smoke-induced-emphysema-via-downregulation-of-oxidative-stress-by-nrf2-keap1-pathway
#13
Sara Vergel Posso, Nicolas Quesnot, João Alfredo Moraes, Lycia Brito-Gitirana, Emanuel Kennedy-Feitosa, Marina Valente Barroso, Luís Cristóvão Porto, Manuella Lanzetti, Samuel Santos Valença
Long-term exposure to cigarette smoke (CS) results in alveolar parenchyma destruction due to chronic inflammatory response and the imbalance between oxidants and antioxidants, and proteases and antiproteases. Emphysema is the main symptom of chronic obstructive pulmonary disease. Current treatment focuses on relieving respiratory symptoms, and inflammation resolution failure is an important pathophysiological element of the disease. Specialized pro-resolving mediators (SPMs) synthesized endogenously during resolution processes demonstrated beneficial effects in murine models of airway inflammation...
February 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29436350/a-longitudinal-study-of-household-water-sanitation-and-hygiene-characteristics-and-environmental-enteropathy-markers-in-children-less-than-24-months-in-iquitos-peru
#14
Natalie G Exum, Gwenyth O Lee, Maribel Paredes Olórtegui, Pablo Peñataro Yori, Mery Siguas Salas, Dixner Rengifo Trigoso, Josh Colston, Kellogg J Schwab, Benjamin J J McCormick, Margaret N Kosek
Poor child gut health, resulting from a lack of access to an improved toilet or clean water, has been proposed as a biological mechanism underlying child stunting and oral vaccine failure. Characteristics related to household sanitation, water use, and hygiene were measured among a birth cohort of 270 children from peri-urban Iquitos Peru. These children had monthly stool samples and urine samples at four time points and serum samples at (2-4) time points analyzed for biomarkers related to intestinal inflammation and permeability...
February 12, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29434972/tanshinone-ii-is-a-potent-candidate-for-treatment-of-lipopolysaccharide-induced-acute-lung-injury-in-rat-model
#15
Ling Li, Yong-Gang Zhang, Yu-Fei Tan, Jing-Jing Zhao, Hua-Ru Zhang, Bing Zhao
The present study aimed to investigate the effect of tanshinone II, isolated from Salvia miltiorrhiza Bunge, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. Male Sprague-Dawley rats were divided into three groups: Control, LPS and tanshinone II. Animals in the tanshinone II and LPS groups were administered 10 mg/kg LPS, whereas those in the control group received an equal volume of normal saline. Tanshinone II treatment group were injected with 30 nm/kg tanshinone II at 1 h after LPS administration...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433672/protective-role-of-%C3%AE-patchoulene-from-pogostemon-cablin-against-indomethacin-induced-gastric-ulcer-in-rats-involvement-of-anti-inflammation-and-angiogenesis
#16
Jia-Zhen Wu, Yu-Hong Liu, Jia-Li Liang, Qiong-Hui Huang, Yao-Xing Dou, Juan Nie, Jian-Yi Zhuo, Xue Wu, Jian-Nan Chen, Zi-Ren Su, Qi-Duan Wu
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are most widely used as effective anti-inflammatory agents. However, their clinical application brings about inevasible gastrointestinal side effects. Pogostemon cablin is a traditional herbal medicine used for the treatment of gastrointestinal diseases in China. One of its representative components, the tricyclic triterpenoid β-patchoulone (β-PAE) has demonstrated great anti-inflammatory activity and gastroprotective effect against ethanol-induced gastric injury, but its protective effect against gastric ulcer induced by indomethacin is still unknown...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29432403/neutrophil-extracellular-traps-in-children-with-meningococcal-sepsis
#17
Tamara Hoppenbrouwers, Navin P Boeddha, Ebru Ekinci, Marieke Emonts, Jan A Hazelzet, Gertjan J Driessen, Moniek P de Maat
OBJECTIVES: Children with meningococcal sepsis are highly at risk for fulminant disease, multiple organ failure, and death. Recently, neutrophil extracellular traps levels have been indicated as a marker for severity in different kinds of sepsis. Our aim was to study the role of neutrophil extracellular traposis in meninogococcal sepsis in children. DESIGN: We measured myeloperoxidase-DNA, a marker for neutrophil extracellular traps, in serum of meningococcal sepsis patients upon admission to PICU, at 24 hours, and at 1 month and studied the association with clinical outcome...
February 9, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29428101/optimized-postconditioning-algorithm-protects-liver-graft-after-liver-transplantation-in-rats
#18
Jian-Hui Li, Jun-Jun Jia, Wen Shen, Sha-Sha Chen, Li Jiang, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng
BACKGROUND: Ischemia reperfusion injury (IRI) causes postoperative complications and influences the outcome of the patients undergoing liver surgery and transplantation. Postconditioning (PostC) is a known manual conditioning to decrease the hepatic IRI. Here we aimed to optimize the applicable PostC protocols and investigate the potential protective mechanism. METHODS: Thirty Sprague-Dawley rats were randomly divided into 3 groups: the sham group (n = 5), standard orthotopic liver transplantation group (OLT, n = 5), PostC group (OLT followed by clamping and re-opening the portal vein for different time intervals, n = 20)...
February 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29427784/evaluation-of-the-treatment-with-resveratrol-loaded-nanoparticles-in-intestinal-injury-model-caused-by-ischemia-and-reperfusion
#19
Stephanie Carvalho Borges, Paulo Emílio Botura Ferreira, Luisa Mota da Silva, Maria Fernanda de Paula Werner, Juan Manuel Irache, Osvaldo Albuquerque Cavalcanti, Nilza Cristina Buttow
The gastrointestinal tract is extremely sensitive to ischemia and reperfusion (I/R). Studies have reported that resveratrol (RSV) is able to combat damage caused by intestinal I/R. Because of its effectiveness in increasing the permanence and bioavailability of resveratrol in the intestinal epithelium, we investigated whether the effect of resveratrol-loaded in poly(anhydride) nanoparticles reduce oxidative stress and promote myenteric neuroprotection in the ileum of rats subjected to I/R. Physicochemical evaluations were performed on nanoparticles...
February 7, 2018: Toxicology
https://www.readbyqxmd.com/read/29427649/rat-strain-differences-in-peritoneal-immune-cell-response-to-selected-gut-microbiota-a-crossroad-between-tolerance-and-autoimmunity
#20
Veljko Blagojević, Vesna Kovačević-Jovanović, Ivana Ćuruvija, Raisa Petrović, Ivana Vujnović, Vesna Vujić, Stanislava Stanojević
AIMS: Some gut commensals can be protective, whereas others are implicated as necessary for development of inflammatory/autoimmune diseases. Peritoneal immune cells may play an important role in promoting autoimmunity in response to gut microbiota. This study investigated the phenotype and the function of peritoneal immune cells in the autoimmunity-resistant Albino Oxford (AO), and the autoimmunity-prone Dark Agouti (DA) rat strains upon stimulation with their own colonic E. coli or Enterococcus...
February 7, 2018: Life Sciences
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