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https://www.readbyqxmd.com/read/29230271/the-role-of-oxidative-stress-in-decreased-acetylcholinesterase-activity-at-the-neuromuscular-junction-of-the-diaphragm-during-sepsis
#1
Hua Liu, Jin Wu, Jun-Yan Yao, Hong Wang, Shi-Tong Li
Our recent study demonstrated that acetylcholinesterase (AChE) activity at the neuromuscular junction (NMJ) of the diaphragm decreased during sepsis. However, the mechanisms were not clearly identified. In this study, we aimed to investigate whether the decreased AChE activity was related to oxidative stress by observing AChE activity in different grades of sepsis induced by caecal ligation and puncture (CLP). At 24 h after surgery, an assay of thiobarbituric acid reactive species (TBARS) and protein carbonyls, as well as the myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activity, was conducted...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29229441/does-dietary-insect-meal-affect-the-fish-immune-system-the-case-of-mealworm-tenebrio-molitor-on-european-sea-bass-dicentrarchus-labrax
#2
M A Henry, L Gasco, S Chatzifotis, G Piccolo
Feeding small European sea bass, Dicentrarchus labrax, for 6 weeks with Tenebrio molitor larval meal showed significant anti-inflammatory responses (ceruloplasmin, myeloperoxidase and nitric oxide). Serum bacteriolytic activity against a Gram negative bacterium was not significantly affected by dietary Tenebrio, while both lysozyme antibacterial activity and serum trypsin inhibition usually linked to the anti-parasite activity of the fish, were significantly enhanced. The latter may be due to the similarities in the composition of the exoskeleton of parasites and insects that may therefore act as an immunostimulant potentially increasing the anti-parasitic activity...
December 8, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29227009/fetal-liver-injury-ameliorated-by-migration-inhibitory-factor-inhibition-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#3
Zheng-Da Guo, Liang Zhao, Peng Wang, Wen-Hong Deng, Qiao Shi, Teng Zuo, Yu-Pu Hong, Wei-Xing Wang
AIM: This study was designed to investigate and assess fetal liver injury in a rat model of acute pancreatitis in pregnancy (APIP) as well as its possible mechanisms and potential therapeutic targets. METHODS: The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP. In addition, sham-operated rats at later gestation were set as controls...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29226969/cudratricusxanthone-a-attenuates-sepsis-induced-liver-injury-via-sirt1-signaling
#4
Yuri Lee, Gil-Saeng Jeong, Wonhwa Lee, Jong-Sup Bae
Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudraniatricuspidata Bureau, is known to possess antithrombotic, antiproliferative and antiinflammatory activities. It remains unclear that CTXA can improve hepatoprotective activity in vivo. The objective of this study was to investigate the effect of CTXA on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate its underlying molecular mechanisms. Liver failure was induced by LPS (15 mg/kg, i.p.) in mice, and 12 h later, they were treated intravenously with CTXA...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226928/evaluation-of-the-in-vivo-acute-antiinflammatory-response-of-curcumin-loaded-nanoparticles
#5
Mariana de Almeida, Bruno Ambrósio da Rocha, Cristhian Rafael Lopes Francisco, Cristiane Grella Miranda, Priscila Dayane de Freitas Santos, Pedro Henrique Hermes de Araújo, Claudia Sayer, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Ciomar Aparecida Bersani-Amado
Curcumin is the main curcuminoid found in turmeric rhizomes and is a strong candidate to formulate foodstuff with specific properties. Among various bioactive properties of curcumin, its antiinflammatory activity is remarkable; on the other hand, its low water solubility leads to low absorption. Thus, new formulations need to be developed to improve its efficacy, and encapsulation is a promising alternative strategy in this regard. The objective of the present study was to obtain curcumin-loaded polyvinylpyrrolidone (PVP) nanoparticles and evaluate their acute in vivo antiinflammatory activity...
December 11, 2017: Food & Function
https://www.readbyqxmd.com/read/29226586/protective-effect-of-gentiopicroside-from-gentiana-macrophylla-pall-in-ethanol-induced-gastric-mucosal-injury-in-mice
#6
Yang Yang, Ziye Wang, Li Zhang, Bing Yin, Le Lv, Jiao He, Ziyang Chen, Xin Wen, Boling Qiao, Wenji Sun, Minfeng Fang, Yongmin Zhang
Gentiopicroside isolated from gentiana macrophylla Pall. belongs to iridoid glycosides. This study aimed to evaluate the protective effect of gentiopicroside against ethanol-induced gastric mucosal injury in mice. Mice were proactively administrated with gentiopicroside by intragastric administration once a day for 3 consecutive days. On the 3rd day, gastric ulcer in mice was induced with 70% ethanol after the last intragastric administration. The stomach tissues were submitted for evaluation of the severity of gastric mucosal alterations...
December 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29223952/isolated-myeloperoxidase-expression-in-pediatric-b-myeloid-mixed-phenotype-acute-leukemia-is-linked-with-better-survival
#7
Sunil S Raikar, Sunita I Park, Traci Leong, David L Jaye, Frank G Keller, John T Horan, William G Woods
No abstract text is available yet for this article.
December 9, 2017: Blood
https://www.readbyqxmd.com/read/29223540/protective-effect-of-coptisine-free-base-on-indomethacin-induced-gastric-ulcers-in-rats-characterization-of-potential-molecular-mechanisms
#8
Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng
AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS: CFB (10, 20 and 40mg/kg), berberine (20mg/kg) and lansoprazole (30mg/kg) were orally administrated to rats prior to indometacin ingestion, and gastric lesions were evaluated macroscopically and histologically, and further analyzed by ELISA, qRT-PCR and Western blot...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29222888/common-food-antimicrobials-effects-on-cellular-inflammation-and-oxidative-damage-and-their-estimated-occurrence-in-singapore
#9
Claudine Loong, Shin Yih Tsen, Xing Lin Ho, Muhammed Faiz B Raman, Wai Mun Loke
BACKGROUND AND OBJECTIVES: The prevalence and potential health effects of common food antimicrobials in processed foods and beverages are relatively unknown in Singapore. The occurrence of chemical antimicrobials in processed foods and beverages and their effects on inflammation and oxidative stress in vitro were examined. METHODS AND STUDY DESIGN: The occurrence of antimicrobials in 1605 processed food and 359 beverage items were examined by surveying the ingredients on the product labels...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222810/monocytes-enhance-neutrophil-induced-blister-formation-in-an-ex-vivo-model-of-bullous-pemphigoid
#10
E de Graauw, C Sitaru, M P Horn, L Borradori, S Yousefi, D Simon, H-U Simon
BACKGROUND: Lesions of bullous pemphigoid (BP), an autoimmune subepidermal blistering disease characterized by the presence of tissue-bound and circulating autoantibodies to hemidesmosomal antigens, harbour a mixed inflammatory cellular infiltrate. In various models, neutrophils, eosinophils, mast cells, monocytes as well as B and T cells have been shown to be involved in the pathogenesis of BP. However, their interactions with and effective role in blister formation remains uncertain...
December 8, 2017: Allergy
https://www.readbyqxmd.com/read/29221940/pioglitazone-attenuates-aging-related-disorders-in-aged-apolipoprotein-e-deficient-mice
#11
Dan Shen, Hao Li, Rui Zhou, Meng-Jie Liu, Hong Yu, Dong-Fang Wu
Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, little is known about the consequences of Piog on aging in aged animal models. We used apolipoprotein E deficient (apoE-/-) mice model to evaluate the effects of Piog on aging-related disorders...
December 5, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29217173/7-fluoro-1-3-diphenylisoquinoline-reverses-motor-and-non-motor-symptoms-induced-by-mptp-in-mice-role-of-striatal-neuroinflammation
#12
Tuane Bazanella Sampaio, Marcel Henrique Marcondes Sari, Ana Paula Pesarico, Anderson Carboni Mantovani, Gilson Zeni, Cristina Wayne Nogueira
Parkinson's disease (PD) is a dopaminergic neurodegenerative disorder, which presents motor and non-motor symptoms.7-Fluoro-1,3-diphenylisoquinoline (FDPI) is an isoquinoline compound with antioxidant and antidepressant properties. This study investigated whether FDPI reverses motor and non-motor symptoms in an acute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). It was also assessed the anti-inflammatory mechanisms in FDPI pharmacological action. C57Bl/6 male adult mice received four MPTP (20mg/kg, intraperitoneal) or saline (vehicle) injections to induce an acute PD model...
December 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29213028/-acute-cholecystitis-due-to-microscopic-polyangiitis-a-case-report
#13
Masaya Kotsuka, Tadashi Tsukamoto, Akishige Kanazawa, Sadatoshi Shimizu, Yoshitaka Nakajima, Shintaro Kodai, Shigeaki Komatsu
A 78-year-old man with chief complaints of cough and lower limb numbness was admitted to our hospital. Serum myeloperoxidase-antineutrophil cytoplasmic antibody titer (MPO-ANCA) was elevated (48.8U/ml), and a diagnosis of microscopic polyangiitis (MPA) was made. After admission, the patient developed a fever and right upper quadrant pain. Ultrasonography and computed tomography revealed an acute cholecystitis of unknown cause, and laparoscopic cholecystectomy was performed. Histopathological examination of the resected gallbladder revealed necrotizing vasculitis along with the infiltration of eosinophils, lymphocytes, and plasma cells around the small arteries in the muscular layer of the gallbladder, which are characteristics of MPA...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29212955/myeloperoxidase-derived-2-chlorofatty-acids-contribute-to-human-sepsis-mortality-via-acute-respiratory-distress-syndrome
#14
Nuala J Meyer, John P Reilly, Rui Feng, Jason D Christie, Stanley L Hazen, Carolyn J Albert, Jacob D Franke, Celine L Hartman, Jane McHowat, David A Ford
Sepsis-associated acute respiratory distress syndrome (ARDS) is characterized by neutrophilic inflammation and poor survival. Since neutrophil myeloperoxidase (MPO) activity leads to increased plasma 2-chlorofatty acid (2-ClFA) levels, we hypothesized that plasma concentrations of 2-ClFAs would associate with ARDS and mortality in subjects with sepsis. In sequential consenting patients with sepsis, free 2-ClFA levels were significantly associated with ARDS, and with 30-day mortality, for each log increase in free 2-chlorostearic acid...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29212118/myeloperoxidase-is-a-negative-regulator-of-phospholipid-dependent-coagulation
#15
Lennart Beckmann, Christina Dicke, Brigitte Spath, Carina Lehr, Bianca Sievers, Anna Klinke, Stephan Baldus, Volker Rudolph, Florian Langer
No abstract text is available yet for this article.
December 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29209329/angiotensin-1-7-promotes-resolution-of-neutrophilic-inflammation-in-a-model-of-antigen-induced-arthritis-in-mice
#16
Lívia C Barroso, Giselle S Magalhaes, Izabela Galvão, Alessandra C Reis, Daniella G Souza, Lirlândia P Sousa, Robson A S Santos, Maria Jose Campagnole-Santos, Vanessa Pinho, Mauro Martins Teixeira
Defective resolution of inflammation may be crucial for the initiation and development of chronic inflammatory diseases, such as arthritis. Therefore, it has been suggested that therapeutic strategies based on molecules that facilitate inflammation resolution present great potential for the treatment of chronic inflammatory diseases. In this study, we investigated the effects and role of angiotensin-(1-7) [Ang-(1-7)] in driving resolution of neutrophilic inflammation in a model of arthritis. For this purpose, male C57BL/6 mice were subjected to antigen-induced arthritis and treated with Ang-(1-7) at the peak of the inflammatory process...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29207058/protective-effect-of-baicalin-against-severe-burn%C3%A2-induced-remote-acute-lung-injury-in-rats
#17
Chongfeng Bai, Tao Li, Qing Sun, Qun Xin, Tongyi Xu, Jinjian Yu, Yun Wang, Li Wei
Baicalin exhibits antibacterial, anti‑viral, anti‑oxidative, antipyretic, analgesic, anti‑inflammatory and anti‑tumor properties. The chemical scavenges oxygen free radicals, protects the cardiovascular system and neurons, protects the liver, and has been used for the prevention and treatment of diabetes‑associated complications. The present study investigated the effect of baicalin on severe burn‑induced remote acute lung injury (ALI). The present study demonstrated that baicalin significantly decreased the lung wet‑to‑dry weight ratio, improved pulmonary histological alterations and reduced the expression of high mobility group protein B1 in the rat model of ALI...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204872/anti-inflammatory-effects-of-rosmarinic-acid-in-lipopolysaccharide-induced-mastitis-in-mice
#18
Kangfeng Jiang, Xiaofei Ma, Shuai Guo, Tao Zhang, Gan Zhao, Haichong Wu, Xiaoyan Wang, Ganzhen Deng
Rosmarinic acid (RA), a type of food additives mainly extracted from rosemary, has been reported to possess anti-inflammatory activities in some previous studies. However, the effects of RA on lipopolysaccharide (LPS)-induced mastitis have not been reported. Here, we investigated the anti-inflammatory effects of RA on LPS-induced mastitis in mice and elucidated the potential mechanisms in mouse mammary epithelial cells (mMECs). RA treatment significantly ameliorated the mammary structural damage, and reduced the activity of myeloperoxidase...
December 4, 2017: Inflammation
https://www.readbyqxmd.com/read/29204780/silver-oxide-nanoparticles-alleviate-indomethacin-induced-gastric-injury-a-novel-antiulcer-agent
#19
Neveen A Salem, Mohammed A Wahba, Wael H Eisa, Marwa El-Shamarka, Wagdy Khalil
Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated. Thus the current study aimed to explore the prospect protective effect of nanosilver oxide against indomethacin-induced gastric ulcer. A new approach has been followed to synthesize nanosilver oxide...
December 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29204117/protective-effect-of-pogostone-on-2-4-6-trinitrobenzenesulfonic-acid-induced-experimental-colitis-via-inhibition-of-t-helper-cell
#20
Jiyan Su, Cailan Li, Xiuting Yu, Guanghua Yang, Jianhua Deng, Ziren Su, Huifang Zeng, Jiannan Chen, Xiaojun Zhang, Xiaoping Lai
Inflammatory bowel disease (IBD) is a chronic immune-related disease mainly caused by the disequilibrium of T helper (Th) cell paradigm? Pogostone (PO) is one of the major chemical constituents of Pogostemon cablin (Blanco) Benth. The present study aims to investigate the potential benefit of PO against IBD in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis model. PO treatment by enema significantly brought down the disease activity index (DAI) of the TNBS-challenged rats, which was manifested by the ameliorated inflammatory features including ulceration, adhesion, and edema...
2017: Frontiers in Pharmacology
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