Tomoya Maeda, Akira Matsuda, Junya Kanda, Hiroshi Kawabata, Takayuki Ishikawa, Kaoru Tohyama, Akira Kitanaka, Kayano Araseki, Kei Shimbo, Tomoko Hata, Takahiro Suzuki, Hidekazu Kayano, Kensuke Usuki, Maki Shindo-Ueda, Nobuyoshi Arima, Masaharu Nohgawa, Akiko Ohta, Shigeru Chiba, Yasushi Miyazaki, Shinji Nakao, Keiya Ozawa, Shunya Arai, Mineo Kurokawa, Akifumi Takaori-Kondo, Kinuko Mitani
Morphological dysplasia in haematopoietic cells, defined by a 10% threshold in each lineage, is one of the diagnostic criteria for myelodysplastic neoplasms. Dysplasia limited to the erythroid lineage has also been reported in some cases of aplastic anaemia (AA); however, its significance remains unclear. We herein examined the impact of erythroid dysplasia on immunosuppressive therapy responses and survival in AA patients. The present study included 100 eligible AA patients without ring sideroblasts. Among them, 32 had dysplasia in the erythroid lineage (AA with minimal dysplasia [mini-D])...
January 31, 2024: British Journal of Haematology