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https://www.readbyqxmd.com/read/27920512/the-burden-of-chronic-obstructive-pulmonary-disease-associated-with-maintenance-monotherapy-in-the-uk
#1
Susan C Edwards, Sian E Fairbrother, Anna Scowcroft, Gavin Chiu, Andrew Ternouth, Brian J Lipworth
BACKGROUND: This study characterized a cohort of chronic obstructive pulmonary disease (COPD) patients on maintenance bronchodilator monotherapy for ≥6 months to establish their disease burden, measured by health care utilization. METHODS: Data were extracted from the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics. The monotherapy period spanned the first prescription of a long-acting β2-adrenergic agonist or a long-acting muscarinic antagonist until the end of the study (December 31, 2013) or until step up to dual/triple therapy, for example, addition of another long-acting bronchodilator, an inhaled corticosteroid, or both...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27912934/effect-of-sequential-treatment-with-tcm-syndrome-differentiation-on-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-aecopd-risk-window
#2
Li Jiansheng, Wang Haifeng, Li Suyun, Zhang Hailong, Yu Xueqing, Zhang Xiaoyun, Li Fengsen, Zhou Xianmei, Sun Zikai, Mao Yimin, Ma Lijun, Zhang Yijie, Zhang Guojun, Tang Bingxiang
OBJECTIVE: To evaluate the efficacy and safety of the comprehensive interventions based on three Traditional Chinese medicine (TCM) patterns therapy in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and AECOPD risk window. METHODS: A prospective, multi-center, single-blinded, double-dummy and randomized controlled clinical trial is being conducted to test the therapeutic effects of a sequential two stage treatment. A total of 364 patients were enrolled into this study with 182 in each treatment group (TCM and conventional)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27891294/prevalence-and-clinical-impact-of-cachexia-in-chronic-illness-in-europe-usa-and-japan-facts-and-numbers-update-2016
#3
EDITORIAL
Stephan von Haehling, Markus S Anker, Stefan D Anker
Cachexia is a serious clinical consequence of almost all chronic diseases when reaching advanced stages. Its prevalence ranges from 5-15% in end-stage chronic heart failure to 50-80% in advanced malignant cancer. Cachexia is also frequently occurring in patients with chronic kidney disease, chronic obstructive pulmonary disease (COPD) or neurological diseases, and rheumatoid arthritis. Mortality rates of patients with cachexia range from 15-25% per year in severe COPD through 20-40% per year in patients with chronic heart failure or chronic kidney disease to 20-80% in cancer cachexia...
December 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27799763/prescription-of-opioids-for-breathlessness-in-end-stage-copd-a-national-population-based-study
#4
Zainab Ahmadi, Eva Bernelid, David C Currow, Magnus Ekström
BACKGROUND: Low-dose opioids can relieve breathlessness but may be underused in late-stage COPD due to fear of complications, contributing to poor symptom control. OBJECTIVES: We aimed to study the period prevalence and indications of opioids actually prescribed in people with end-stage COPD. METHODS: The study was a longitudinal, population-based study of patients starting long-term oxygen therapy (LTOT) for COPD between October 1, 2005 and June 30, 2009 in Sweden...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27755550/the-ser82-rage-variant-affects-lung-function-and-serum-rage-in-smokers-and-srage-production-in-vitro
#5
Suzanne Miller, Amanda P Henry, Emily Hodge, Alexander K Kheirallah, Charlotte K Billington, Tracy L Rimington, Sangita K Bhaker, Ma'en Obeidat, Erik Melén, Simon K Merid, Caroline Swan, Catherine Gowland, Carl P Nelson, Ceri E Stewart, Charlotte E Bolton, Iain Kilty, Anders Malarstig, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Ian P Hall, Ian Sayers
INTRODUCTION: Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encoding RAGE). We aimed to (i) characterise RAGE expression in the lung, (ii) identify AGER transcripts, (iii) ascertain if SNP rs2070600 (Gly82Ser C/T) is associated with lung function and serum sRAGE levels and (iv) identify whether the Gly82Ser variant is functionally important in altering sRAGE levels in an airway epithelial cell model...
2016: PloS One
https://www.readbyqxmd.com/read/27698749/randomized-double-blind-placebo-controlled-superiority-trial-of-the-yiqigubiao-pill-for-the-treatment-of-patients-with-chronic-obstructive-pulmonary-disease-at-a-stable-stage
#6
Feng-Sen Li, Yan-Li Zhang, Zheng Li, Dan Xu, Chun-Yan Liao, Huan Ma, Li Gong, Jun Su, Qi Sun, Qian Xu, Zhen Gao, Ling Wang, Jing Jing, Jing Wang, Min Jiang, Ge Tian, Bilal Hasan
In traditional Chinese medicine (TCM), the Yiqigubiao pill is commonly used to enhance physical fitness. The current clinical trial was designed to evaluate the efficacy and safety of the Yiqigubiao pill as an adjuvant therapy for patients with stable chronic obstructive pulmonary disease (COPD). The current trial was a randomized, double-blind, placebo-controlled superiority trial. The participants were recruited from outpatients at the Traditional Chinese Medicine Hospital affiliated with Xinjiang Medical University (Ürümqi, China) between February and September 2012...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27611719/contractile-capability-of-the-diaphragm-assessed-by-ultrasonography-predicts-nocturnal-oxygen-saturation-in-copd
#7
Kazuki Okura, Atsuyoshi Kawagoshi, Masahiro Iwakura, Keiyu Sugawara, Hitomi Takahashi, Takeshi Kashiwagura, Mitsunobu Homma, Masahiro Satake, Takanobu Shioya
BACKGROUND AND OBJECTIVE: Diaphragm function might be useful to predict nocturnal oxygen desaturation in COPD. Ultrasonography has been widely used for the assessment of the diaphragm. We aimed to investigate the relationship between the contractile capability of the diaphragm assessed by ultrasonography and the nocturnal percutaneous arterial oxygen saturation (NSpO2 ) in COPD. METHODS: Twenty-eight male patients with COPD (age, 73 ± 7 years; forced expiratory volume in 1 s (FEV1 ), 54...
September 9, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27607547/clinical-outcomes-with-a-systolic-blood-pressure-lower-than-120%C3%A2-mmhg-in-older-patients-with-high-disease-burden
#8
Carlos R Franco Palacios, Eric N Haugen, Amanda M Thompson, Richard W Rasmussen, Nathan Goracke, Pankaj Goyal
BACKGROUND: The target blood pressure in older patients is controversial. Recent studies provided clinical evidence supporting a target systolic blood pressure <120 mmHg in patients >50 years at high risk of cardiovascular events. METHODS: Retrospective study of 380 consecutive patients ≥60 years with stages 1-5 pre-dialysis chronic kidney disease seen between January 2013 and November 2015. The outcomes of a systolic blood pressure <120 mmHg in older patients with chronic kidney disease and multiple comorbidities were analyzed...
September 8, 2016: Renal Failure
https://www.readbyqxmd.com/read/27600155/space-a-randomized-study-of-sbrt-vs-conventional-fractionated-radiotherapy-in-medically-inoperable-stage-i-nsclc
#9
Jan Nyman, Andreas Hallqvist, Jo-Smund Lund, Odd-Terje Brustugun, Bengt Bergman, Per Bergström, Signe Friesland, Rolf Lewensohn, Erik Holmberg, Ingmar Lax
BACKGROUND: Stereotactic body radiotherapy (SBRT) has been introduced for small lung tumors due to excellent local control and few side effects, even though there are no comparative studies. SPACE (Stereotactic Precision And Conventional radiotherapy Evaluation) is the first randomized phase II trial comparing SBRT and conventional fractionated radiotherapy (3DCRT). METHODS: Patients with stage I medically inoperable NSCLC were randomized to receive SBRT to 66Gy in 3 fractions (one week) or 3DCRT to 70Gy (7weeks)...
September 3, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27575552/relation-of-concavity-in-the-expiratory-flow-volume-loop-to-dynamic-hyperinflation-during-exercise-in-copd
#10
Janos Varga, Richard Casaburi, Shuyi Ma, Ariel Hecht, David Hsia, Attila Somfay, Janos Porszasz
Active expiration during exercise can increase intrathoracic pressure yielding concavity in the expiratory flow-volume loop in COPD. We investigated the relationship between this concavity and dynamic hyperinflation (DH). 17 COPD patients (FEV1: 38±10%pred, GOLD stage 3-4) and 12 healthy subjects performed cycle ergometer incremental exercise. Expiratory limb of the spontaneous flow-volume loop was analyzed breath-by-breath using a geometric approach (rectangular area ratio (RAR), Respir. Med., 104(3):389-96, 2010)...
August 26, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27512321/a-randomized-controlled-study-on-assessment-of-health-status-depression-and-anxiety-in-coal-miners-with-chronic-obstructive-pulmonary-disease-following-yoga-training
#11
Rajashree Ranjita, Sumati Badhai, Alex Hankey, Hongasandra R Nagendra
CONTEXT: Psychological comorbidities are prevalent in coal miners with chronic obstructive pulmonary disease (COPD) and contribute to the severity of the disease reducing their health status. Yoga has been shown to alleviate depression and anxiety associated with other chronic diseases but in COPD not been fully investigated. AIM: This study aimed to evaluate the role of yoga on health status, depression, and anxiety in coal miners with COPD. MATERIALS AND METHODS: This was a randomized trial with two study arms (yoga and control), which enrolled 81 coal miners, ranging from 36 to 60 years with stage II and III stable COPD...
July 2016: International Journal of Yoga
https://www.readbyqxmd.com/read/27501819/the-role-of-tumor-necrosis-factor-alpha-and-tnf-superfamily-members-in-bone-damage-in-patients-with-end-stage-chronic-obstructive-lung-disease-prior-to-lung-transplantation
#12
Evgenia A Kochetkova, Vera A Nevzorova, Ludmila G Ugai, Yulia V Maistrovskaia, Gilbert Massard
A disequilibrium of tumor necrosis superfamily (TNF) members, including the serum osteoprotegerin, soluble receptor activator of nuclear factor-κB ligand, soluble TNF-related apoptosis-inducing ligand and TNF-α, was associated with the occurrence of a reduced skeletal mass and osteoporosis in male patients with end-stage chronic obstructive pulmonary disease (COPD). The purpose of this study was to explore the associations between serum biomarkers of tumor necrosis factor (TNF) superfamily and body and bone compositions in end-stage COPD males...
August 8, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27495022/prevalence-and-impact-of-clostridium-difficile-infection-in-elderly-residents-of-long-term-care-facilities-2011-a-nationwide-study
#13
Panayiotis D Ziakas, Nina Joyce, Ioannis M Zacharioudakis, Fainareti N Zervou, Richard W Besdine, Vincent Mor, Eleftherios Mylonakis
The elderly population is particularly vulnerable to Clostridium difficile infection (CDI), but the epidemiology of CDI in long-term care facilities (LTCFs) is unknown.We performed a retrospective cohort study and used US 2011 LTCF resident data from the Minimum Data Set 3.0 linked to Medicare claims. We extracted CDI cases based on International Classification of Diseases-9 coding, and compared residents with the diagnosis of CDI to those who did not have a CDI diagnosis during their LTCF stay. We estimated CDI prevalence rates and calculated 3-month mortality rates...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27468231/associations-of-autophagy-with-lung-diffusion-capacity-and-oxygen-saturation-in-severe-copd-effects-of-particulate-air-pollution
#14
Kang-Yun Lee, Ling-Ling Chiang, Shu-Chuan Ho, Wen-Te Liu, Tzu-Tao Chen, Po-Hao Feng, Chien-Ling Su, Kai-Jen Chuang, Chih-Cheng Chang, Hsiao-Chi Chuang
Although traffic exposure has been associated with the development of COPD, the role of particulate matter <10 μm in aerodynamic diameter (PM10) in the pathogenesis of COPD is not yet fully understood. We assessed the 1-year effect of exposure to PM10 on the pathogenesis of COPD in a retrospective cohort study. We recruited 53 subjects with COPD stages III and IV and 15 healthy controls in a hospital in Taiwan. We estimated the 1-year annual mean levels of PM10 at all residential addresses of the cohort participants...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27460913/sitagliptin-and-risk-of-heart-failure-hospitalization-in-patients-with-type-2-diabetes-on-dialysis-a-population-based-cohort-study
#15
Yi-Chih Hung, Che-Chen Lin, Wei-Lun Huang, Man-Ping Chang, Ching-Chu Chen
The incidence of heart failure hospitalization (HHF) after taking sitagliptin in type 2 diabetes (T2DM) patients with end stage renal disease (ESRD) on dialysis is unclear. In this population-based cohort study, we identified individuals with T2DM and ESRD on dialysis who were treated with sitagliptin between 2009 and 2011 and randomly selected a control cohort matched by age, sex, duration of T2DM, hypertension medications, use of statin and aspirin, sulfonylureas, glinides, and insulin usage, atherosclerotic heart disease, congestive heart failure and chronic obstructive pulmonary disease at a 1:4 ratio...
July 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27449634/validation-of-the-hospital-score-for-30-day-all-cause-readmissions-of-patients-discharged-to-skilled-nursing-facilities
#16
Luke D Kim, Lei Kou, Barbara J Messinger-Rapport, Michael B Rothberg
OBJECTIVES: To validate the HOSPITAL score for predicting 30-day all-cause readmission rates in a cohort of medical patients discharged to skilled nursing facilities (SNFs). DESIGN: Retrospective cohort. SETTING: Cleveland Clinic Main Campus. PARTICIPANTS: Cleveland Clinic Main Campus medicine services patients who were admitted between January 1, 2011, and December 31, 2012, and subsequently discharged to 110 SNFs within a 25-mile radius of the hospital...
September 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27423782/accuracy-of-ct-pulmonary-artery-diameter-for-pulmonary-hypertension-in-end-stage-copd
#17
Firdaus A Mohamed Hoesein, Tim Besselink, Esther Pompe, Erik-Jan Oudijk, Ed A de Graaf, J M Kwakkel-van Erp, Pim A de Jong, Bart Luijk
INTRODUCTION: Pulmonary hypertension (PH) in COPD is associated with a higher mortality and an increased risk on exacerbations compared to COPD patients without PH. The aim was to evaluate the diagnostic value of pulmonary artery (PA) measurements on chest computed tomography (CT) for PH in end-stage COPD. METHODS: COPD patients evaluated for eligibility for lung transplantation between 2004 and 2015 were retrospectively analyzed. Clinical characteristics, chest CTs, spirometry, and right-sided heart catheterizations (RHC) were studied...
October 2016: Lung
https://www.readbyqxmd.com/read/27403248/evaluation-of-risk-factors-for-intravenous-colistin-use-related-nephrotoxicity
#18
Iftihar Koksal, Selcuk Kaya, Eda Gencalioglu, Gurdal Yilmaz
OBJECTIVES: We investigated the incidence of and risk factors for nephrotoxicity in patients using intravenous colistin. METHODS: This retrospective, observational study was conducted at Karadeniz Technical University, Faculty of Medicine, clinics and intensive care unit between 1 January 2009 and 1 January 2013. Intravenous colistin was administered to 133 patients at a dose of 2.5-5.0 mg/kg/day. RESULTS: The patients mean age was 54.3±19...
July 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27387892/utilization-of-palliative-care-in-patients-with-end-stage-chronic-obstructive-pulmonary-disease-on-home-oxygen-national-trends-and-barriers-to-care-in-the-united-states
#19
Barret Rush, Paul Hertz, Alexandra Bond, Robert McDermid, Leo Anthony Celi
OBJECTIVE: To investigate the use of palliative care (PC) in patients with end-stage chronic obstructive pulmonary disease (COPD) on home oxygen hospitalized for an exacerbation METHODS: Retrospective nationwide cohort analysis utilising the Nationwide Inpatient Sample (NIS). All patients >18 years of age with a diagnosis of COPD on home oxygen admitted for an exacerbation were included. RESULTS: 55,208,382 hospitalizations from the 2006-2012 NIS samples were examined...
July 4, 2016: Chest
https://www.readbyqxmd.com/read/27367547/quality-of-end-of-life-care-provided-to-patients-with-different-serious-illnesses
#20
Melissa W Wachterman, Corey Pilver, Dawn Smith, Mary Ersek, Stuart R Lipsitz, Nancy L Keating
IMPORTANCE: Efforts to improve end-of-life care have focused primarily on patients with cancer. High-quality end-of-life care is also critical for patients with other illnesses. OBJECTIVE: To compare patterns of end-of-life care and family-rated quality of care for patients dying with different serious illnesses. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cross-sectional study was conducted in all 146 inpatient facilities within the Veteran Affairs health system among patients who died in inpatient facilities between October 1, 2009, and September 30, 2012, with clinical diagnoses categorized as end-stage renal disease (ESRD), cancer, cardiopulmonary failure (congestive heart failure or chronic obstructive pulmonary disease), dementia, frailty, or other conditions...
August 1, 2016: JAMA Internal Medicine
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