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https://www.readbyqxmd.com/read/28213831/a-phenomenological-cohesive-model-for-the-macroscopic-simulation-of-cell-matrix-adhesions
#1
M Cóndor, J M García-Aznar
Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact, adherent cells can generate physical forces that are transmitted to the surrounding matrix, regulating the formation of cell-matrix adhesions. The main purpose of this work is to develop a computational model to simulate the dynamics of cell-matrix adhesions through a cohesive formulation within the framework of the finite element method and based on the principles of continuum damage mechanics...
February 17, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28213599/health-information-needs-source-preferences-and-engagement-behaviours-of-women-with-metastatic-breast-cancer-across-the-care-continuum-protocol-for-a-scoping-review
#2
Carol A Tucker, M Pilar Martin, Ray B Jones
INTRODUCTION: The health information needs, information source preferences and engagement behaviours of women with metastatic breast cancer (mBC) depend on personal characteristics such as education level, prior knowledge, clinical complications, comorbidities and where they are in the cancer journey. A thorough understanding of the information behaviours of women living with mBC is essential to the provision of optimal care. A preliminary literature review suggests that there is little research on this topic, but that there may be lessons from a slightly broader literature...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28212506/dimensional-and-discrete-variations-on-the-psychosis-continuum-in-a-dutch-crowd-sourcing-population-sample
#3
J T W Wigman, K J Wardenaar, R B K Wanders, S H Booij, B F Jeronimus, L van der Krieke, M Wichers, P de Jonge
BACKGROUND: Mild psychotic experiences are common in the general population. Although transient and benign in most cases, these experiences are predictive of later mental health problems for a significant minority. The goal of the present study was to perform examinations of the dimensional and discrete variations in individuals' reporting of subclinical positive and negative psychotic experiences in a unique Dutch internet-based sample from the general population. METHODS: Positive and negative subclinical psychotic experiences were measured with the Community Assessment of Psychic Experiences in 2870 individuals...
December 18, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28212316/succinimide-formation-from-an-ngr-containing-cyclic-peptide-computational-evidence-for-catalytic-roles-of-phosphate-buffer-and-the-arginine-side-chain
#4
Ryota Kirikoshi, Noriyoshi Manabe, Ohgi Takahashi
The Asn-Gly-Arg (NGR) motif and its deamidation product isoAsp-Gly-Arg (isoDGR) have recently attracted considerable attention as tumor-targeting ligands. Because an NGR-containing peptide and the corresponding isoDGR-containing peptide target different receptors, the spontaneous NGR deamidation can be used in dual targeting strategies. It is well known that the Asn deamidation proceeds via a succinimide derivative. In the present study, we computationally investigated the mechanism of succinimide formation from a cyclic peptide, c[CH₂CO-NGRC]-NH₂, which has recently been shown to undergo rapid deamidation in a phosphate buffer...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211994/building-the-coverage-continuum-the-role-of-state-medicaid-directors-and-insurance-commissioners
#5
Joel Ario, Deborah Bachrach
Issue: The Affordable Care Act has expanded coverage to 20 million newly insured individuals, split between state Medicaid programs and commercially insured marketplaces, with limited integration between the two. The seamless continuum of coverage envisioned by the law is central to achieving the full potential of the Affordable Care Act, but it remains an elusive promise. Goals: To examine the historical and cultural differences between state Medicaid agencies and insurance departments that contribute to this lack of coordination...
2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28211736/short-time-behavior-and-criticality-of-driven-lattice-gases
#6
Urna Basu, Valerio Volpati, Sergio Caracciolo, Andrea Gambassi
The nonequilibrium short-time critical behaviors of driven and undriven lattice gases are investigated via Monte Carlo simulations in two spatial dimensions starting from a fully disordered initial configuration. In particular, we study the time evolution of suitably defined order parameters, which account for the strong anisotropy introduced by the homogeneous drive. We demonstrate that, at short times, the dynamics of all these models is unexpectedly described by an effective continuum theory in which transverse fluctuations, i...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211730/kinetic-turbulence-in-relativistic-plasma-from-thermal-bath-to-nonthermal-continuum
#7
Vladimir Zhdankin, Gregory R Werner, Dmitri A Uzdensky, Mitchell C Begelman
We present results from particle-in-cell simulations of driven turbulence in magnetized, collisionless, and relativistic pair plasmas. We find that the fluctuations are consistent with the classical k_{⊥}^{-5/3} magnetic energy spectrum at fluid scales and a steeper k_{⊥}^{-4} spectrum at sub-Larmor scales, where k_{⊥} is the wave vector perpendicular to the mean field. We demonstrate the development of a nonthermal, power-law particle energy distribution f(E)∼E^{-α}, with an index α that decreases with increasing magnetization and increases with an increasing system size (relative to the characteristic Larmor radius)...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211583/in%C3%A2-situ-temperature-response-of-photosynthesis-of-42-tree-and-liana-species-in-the-canopy-of-two-panamanian-lowland-tropical-forests-with-contrasting-rainfall-regimes
#8
Martijn Slot, Klaus Winter
Tropical forests contribute significantly to the global carbon cycle, but little is known about the temperature response of photosynthetic carbon uptake in tropical species, and how this varies within and across forests. We determined in situ photosynthetic temperature-response curves for upper canopy leaves of 42 tree and liana species from two tropical forests in Panama with contrasting rainfall regimes. On the basis of seedling studies, we hypothesized that species with high photosynthetic capacity - light-demanding, fast-growing species - would have a higher temperature optimum of photosynthesis (TOpt ) than species with low photosynthetic capacity - shade-tolerant, slow-growing species - and that, therefore, TOpt would scale with the position of a species on the slow-fast continuum of plant functional traits...
February 17, 2017: New Phytologist
https://www.readbyqxmd.com/read/28210880/can-fe-3-and-al-3-ions-serve-as-cationic-bridges-to-facilitate-the-adsorption-of-anionic-as-v-species-on-humic-acids-a-density-functional-theory-study
#9
Leonid Gorb, Manoj K Shukla
A computational chemistry investigation was undertaken to shed light on the facilitatory role played by Fe(3+) and Al(3+) cations in the adsorption of anionic As(V) species by humic acids through the formation of so-called cationic bridges. Geometric and energetic parameters were obtained using density functional theory at the B3LYP/6-31G(d,p) level in conjunction with the polarizable continuum model (to account for the influence of bulk water). We found that, despite their similar molecular geometries, the adsorption energies of the As(V) species AsO4(3-) and H2AsO(4-) differ when Fe(3+), FeOH(2+), Al(3+), and AlOH(2+) participate in the bridge...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28210879/theoretical-study-of-the-spectroscopic-and-nonlinear-optical-properties-of-trans-and-cis-4-hydroxyazobenzene
#10
Hai-Peng Li, Ze-Tong Bi, Wen-Yue Fu, Run-Feng Xu, Yi Zhang, Xiao-Peng Shen, Ming-Xue Li, Gang Tang, Kui Han
We investigate the molecular structure, vibrational and electronic absorption spectra, and electronic hyperpolarizabilities of trans and cis isomers of 4-hydroxyazobenzene (HOAB) via density functional theory. Results show that the azo dye exhibits a high third-order nonlinear optical response and good optical transparency. Both the basis set and the functional are important influences on the results obtained when calculating the absorption spectrum and NLO response. We also study the effect of the solvent on the electronic absorption spectrum to assess the ability of the functional to reproduce the experimental spectrum in combination with a suitable solvent model...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28210351/cross-continuum-tool-is-associated-with-reduced-utilization-and-cost-for-frequent-high-need-users
#11
Lauran Hardin, Adam Kilian, Leslie Muller, Kevin Callison, Michael Olgren
INTRODUCTION: High-need, high-cost (HNHC) patients can over-use acute care services, a pattern of behavior associated with many poor outcomes that disproportionately contributes to increased U.S. healthcare cost. Our objective was to reduce healthcare cost and improve outcomes by optimizing the system of care. We targeted HNHC patients and identified root causes of frequent healthcare utilization. We developed a cross-continuum intervention process and a succinct tool called a Complex Care Map (CCM)© that addresses fragmentation in the system and links providers to a comprehensive individualized analysis of the patient story and causes for frequent access to health services...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28209215/the-relevance-of-goal-orientation-for-motivation-in-high-versus-low-proneness-to-negative-symptoms
#12
Björn Schlier, Maike Engel, Anne-Katharina Fladung, Anja Fritzsche, Tania M Lincoln
BACKGROUND: The psychological mechanisms of why individuals with negative symptoms fail to initiate and perform goal-directed behavior are not well understood. Drawing on the reward-sensitivity and expectancy-value theories, we investigate whether negative symptom-like experiences (NSLE) are associated with generating less approach goals (aimed at reaching a positive outcome) and more avoidance goals (aimed at avoiding a negative outcome) and whether this type of goal-orientation explains motivational deficits (i...
June 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28208471/analysis-of-thermodiffusive-cellular-instabilities-in-continuum-combustion-fronts
#13
Hossein Azizi, Sebastian Gurevich, Nikolas Provatas
We explore numerically the morphological patterns of thermodiffusive instabilities in combustion fronts with a continuum fuel source, within a range of Lewis numbers and ignition temperatures, focusing on the cellular regime. For this purpose, we generalize the recent model of Brailovsky et al. to include distinct process kinetics and reactant heterogeneity. The generalized model is derived analytically and validated with other established models in the limit of infinite Lewis number for zero-order and first-order kinetics...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208423/modeling-angiogenesis-a-discrete-to-continuum-description
#14
Samara Pillay, Helen M Byrne, Philip K Maini
Angiogenesis is the process by which new blood vessels develop from existing vasculature. During angiogenesis, endothelial tip cells migrate via diffusion and chemotaxis, loops form via tip-to-tip and tip-to-sprout anastomosis, new tip cells are produced via branching, and a vessel network forms as endothelial cells follow the paths of tip cells. The latter process is known as the snail trail. We use a mean-field approximation to systematically derive a continuum model from a two-dimensional lattice-based cellular automaton model of angiogenesis in the corneal assay, based on the snail-trail process...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208413/friction-factor-for-aerosol-fractal-aggregates-over-the-entire-knudsen-range
#15
James Corson, George W Mulholland, Michael R Zachariah
We develop an approach for computing the hydrodynamic friction tensor and scalar friction coefficient for an aerosol fractal aggregate in the transition regime. Our approach involves solving the Bhatnagar-Gross-Krook equation for the velocity field around a sphere and using the velocity field to calculate the force on each primary sphere in the aggregate due to the presence of the other spheres. It is essentially an extension of Kirkwood-Riseman theory from the continuum flow regime to the entire Knudsen range (Knudsen number from 0...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208403/exactly-solvable-model-for-cluster-size-distribution-in-a-closed-system
#16
V G Dubrovskii
We obtain an exact solution for the cluster-size distributions in a closed system described by nonlinear rate equations for irreversible homogeneous growth with size-linear agglomeration rates of the form K_{s}=D(a+s-1) for all s≥1, where D is the diffusion coefficient, s is the size, and a is a positive constant. The size spectrum is given by the Pólya distribution times a factor that normalizes the first moment of the distribution to unity and zeroes out the monomer concentration at t→∞. We show that the a value sets a maximum mean size that equals e for large a and tends to infinity only when a→0...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207600/advancements-in-the-critical-care-management-of-status-epilepticus
#17
Andrew Bauerschmidt, Andrew Martin, Jan Claassen
PURPOSE OF REVIEW: Status epilepticus has a high morbidity and mortality. There are little definitive data to guide management; however, new recent data continue to improve understanding of management options of status epilepticus. This review examines recent advancements regarding the critical care management of status epilepticus. RECENT FINDINGS: Recent studies support the initial treatment of status epilepticus with early and aggressive benzodiazepine dosing...
February 14, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28207069/continuum-of-care-for-hcv-among-patients-diagnosed-in-the-emergency-department-setting
#18
Erik S Anderson, James W Galbraith, Laura J Deering, Sarah K Pfeil, Tamara Todorovic, Joel B Rodgers, Jordan M Forsythe, Ricardo Franco, Henry Wang, N Ewen Wang, Douglas A E White
No abstract text is available yet for this article.
February 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28205402/quantum-chemistry-descriptors-for-photosensitizers-based-on-macrocycles
#19
Fernanda Bettanin, Felipe C T Antonio, Kathia M Honorio, Paula Homem-de-Mello
Phthalocyanines, porphyrins, and chlorins have been widely studied as photosensitizers. Both experimental and computational strategies are employed in order to propose new and more active molecules derived from those macrocycles. In this context, there are two main strategies used: (i) the addition of different substituents and (ii) the complexation of the macrocycle with different metallic ions. In this work, we present selected descriptors based on quantum chemistry calculations for forty macrocycles, including some approved drugs...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28204614/a-continuum-of-mrnp-complexes-in-embryonic-microrna-mediated-silencing
#20
Edlyn Wu, Ajay A Vashisht, Clément Chapat, Mathieu N Flamand, Emiliano Cohen, Mihail Sarov, Yuval Tabach, Nahum Sonenberg, James Wohlschlegel, Thomas F Duchaine
No abstract text is available yet for this article.
February 28, 2017: Nucleic Acids Research
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