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https://www.readbyqxmd.com/read/28088537/mouse-models-of-frontotemporal-dementia-a-comparison-of-phenotypes-with-clinical-symptomatology
#1
REVIEW
Rebekah M Ahmed, Muireann Irish, Janet van Eersel, Arne Ittner, Yazi D Ke, Alexander Volkerling, Julia van der Hoven, Kimi Tanaka, Tim Karl, Michael Kassiou, Jillian J Kril, Olivier Piguet, Jürgen Götz, Matthew C Kiernan, Glenda M Halliday, John R Hodges, Lars M Ittner
Frontotemporal dementia (FTD) is the second most common cause of young onset dementia. It is increasingly recognized that there is a clinical continuum between FTD and amyotrophic lateral sclerosis (ALS). At a clinical, pathological and genetic level there is much heterogeneity in FTD, meaning that our understanding of this condition, pathophysiology and development of treatments has been limited. A number of mouse models focusing predominantly on recapitulating neuropathological and molecular changes of disease have been developed, with most transgenic lines expressing a single specific protein or genetic mutation...
January 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28088211/innovation-contests-to-promote-sexual-health-in-china-a-qualitative-evaluation
#2
Wei Zhang, David Schaffer, Lai Sze Tso, Songyuan Tang, Weiming Tang, Shujie Huang, Bin Yang, Joseph D Tucker
BACKGROUND: Innovation contests call on non-experts to help solve problems. While these contests have been used extensively in the private sector to increase engagement between organizations and clients, there is little data on the role of innovation contests to promote health campaigns. We implemented an innovation contest in China to increase sexual health awareness among youth and evaluated community engagement in the contest. METHODS: The sexual health image contest consisted of an open call for sexual health images, contest promotion activities, judging of entries, and celebrating contributions...
January 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28088152/theoretical-description-of-circular-dichroism-in-photoelectron-angular-distributions-of-randomly-oriented-chiral-molecules-after-multi-photon-photoionization
#3
R E Goetz, T A Isaev, B Nikoobakht, R Berger, C P Koch
Photoelectron circular dichroism refers to the forward/backward asymmetry in the photoelectron angular distribution with respect to the propagation axis of circularly polarized light. It has recently been demonstrated in femtosecond multi-photon photoionization experiments with randomly oriented camphor and fenchone molecules [C. Lux et al., Angew. Chem., Int. Ed. 51, 4755 (2012) and C. S. Lehmann et al., J. Chem. Phys. 139, 234307 (2013)]. A theoretical framework describing this process as (2+1) resonantly enhanced multi-photon ionization is constructed, which consists of two-photon photoselection from randomly oriented molecules and successive one-photon ionization of the photoselected molecules...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088134/dirac-bubble-potential-for-he-he-and-inadequacies-in-the-continuum-comparing-an-analytic-model-with-elastic-collision-experiments
#4
Michael Chrysos
We focus on the long-pending issue of the inadequacy of the Dirac bubble potential model in the description of He-He interactions in the continuum [L. L. Lohr and S. M. Blinder, Int. J. Quantum Chem. 53, 413 (1995)]. We attribute this failure to the lack of a potential wall to mimic the onset of the repulsive interaction at close range separations. This observation offers the explanation to why this excessively simple model proves incapable of quantitatively reproducing previous experimental findings of glory scattering in He-He, although being notorious for its capability of reproducing several distinctive features of the atomic and isotopic helium dimers and trimers [L...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088125/computational-methods-for-analyzing-conformational-variability-of-macromolecular-complexes-from-cryo-electron-microscopy-images
#5
REVIEW
Slavica Jonić
Thanks to latest technical advances in cryo-electron microscopy (cryo-EM), structures of macromolecular complexes (viruses, ribosomes, etc.) are now often obtained at near-atomic resolution. Also, studies of conformational changes of complexes, in connection with their function, are gaining ground. Conformational variability analysis is usually done by classifying images in a number of discrete classes supposedly representing all conformational states present in the specimen. However, discrete classes cannot be meaningfully defined when the conformational change is continuous (the specimen contains a continuum of states instead of a few discrete states)...
January 11, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28087719/genetics-insight-into-the-amyotrophic-lateral-sclerosis-frontotemporal-dementia-spectrum
#6
REVIEW
Ai-Ling Ji, Xia Zhang, Wei-Wei Chen, Wen-Juan Huang
Recent genetic discoveries have dramatically changed our understanding of two major neurodegenerative conditions. Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are common, devastating diseases of the brain. For decades, ALS and FTD were classified as movement and cognitive disorders, respectively, due to their distinct clinical phenotypes. The recent identification of chromosome 9 open reading frame 72 (C9orf72) as the major gene causative of familial forms of ALS and FTD uncovered a new reality of a continuous FTD/ALS spectrum...
January 13, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28087628/id4-levels-dictate-the-stem-cell-state-in-mouse-spermatogonia
#7
Aileen R Helsel, Qi-En Yang, Melissa J Oatley, Tessa Lord, Fred Sablitzky, Jon M Oatley
Spermatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell self-renewal for continuity and formation of progenitors as the initial step in production of differentiated cells. However, the mechanisms guiding the continuum of spermatogonial stem cell (SSC) to progenitor spermatogonial transition and precise identifiers of subtypes in the process are undefined. Here we used an Id4-eGfp reporter mouse to discover that EGFP intensity is predictive of the subsets with the ID4-EGFP(Bright) population being mostly, if not purely, SSCs while the ID4-EGFP(Dim) population is in transition to the progenitor state...
January 13, 2017: Development
https://www.readbyqxmd.com/read/28079722/development-and-preliminary-pilot-testing-of-a-peer-support-text-messaging-intervention-for-hiv-infected-black-men-who-have-sex-with-men
#8
Theresa E Senn, Amy Braksmajer, Patricia Coury-Doniger, Marguerite A Urban, Adam Rossi, Michael P Carey
BACKGROUND: Black men who have sex with men (MSM) are disproportionately infected with HIV and are less well retained along the HIV continuum of care. We report on the feasibility of a peer support text messaging intervention designed to increase retention in HIV care and HIV medication adherence among HIV-infected black men who have sex with men. METHODS: Based on formative research, a cell phone app was developed to support a peer-based text messaging intervention...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28079721/an-exploratory-study-to-assess-individual-and-structural-level-barriers-associated-with-poor-retention-and-re-engagement-in-care-among-persons-living-with-hiv-aids
#9
Jonathan Colasanti, Natalie Stahl, Eugene W Farber, Carlos Del Rio, Wendy S Armstrong
BACKGROUND: Retention in care is the most challenging step along the HIV care continuum. Many patients who engage in care and achieve viral suppression have care interruptions, characterized by moving in and out of care ("churn"). Poor retention has clinical consequences and contributes to new HIV transmissions, but how to predict or prevent it remains elusive. This study sought to understand the relationship between individual- and structural-level barriers, and poor retention for persons living with HIV/AIDS in Atlanta, GA...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28079719/feasibility-of-using-hiv-care-continuum-outcomes-to-identify-geographic-areas-for-targeted-hiv-testing
#10
Amanda D Castel, Irene Kuo, Meriam Mikre, Toni Young, Meredith Haddix, Suparna Das, Geoffrey Maugham, Carol Reisen
BACKGROUND: Improved detection and linkage to care of previously undiagnosed HIV infections require innovative approaches to testing. We sought to determine the feasibility of targeted HIV testing in geographic areas, defined by continuum of care parameters, to identify HIV-infected persons needing linkage or engagement in care. METHODS: Using HIV surveillance data from Washington, DC, we identified census tracts that had an HIV prevalence >1% and were either above (higher risk areas-HRAs) or below (lower risk areas-LRAs) the median for 3 indicators: monitored viral load, proportion of persons out of care (OOC), and never in care...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28079717/-out-of-care-hiv-case-investigations-a-collaborative-analysis-across-6-states-in-the-northwest-us
#11
Julia C Dombrowski, Joanna Bove, James C Roscoe, Jessica Harvill, Caislin L Firth, Shireen Khormooji, Jason Carr, Peter Choi, Courtney Smith, Sean D Schafer, Matthew R Golden
BACKGROUND: HIV care continuum estimates derived from laboratory surveillance typically assume that persons without recently reported CD4 count or viral load results are out of care. METHODS: We conducted a multistate project (Alaska, Idaho, Montana, Oregon, Washington, and Wyoming) to ascertain the status of HIV cases that appeared to be out of care during a 12-month period. We used laboratory surveillance to identify cases in all states but Idaho, where viral load reporting is not mandatory, requiring us to rely on clinic records...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28079716/promotion-of-research-on-the-hiv-continuum-of-care-in-the-united-states-the-cfar-hiv-continuum-of-care-echpp-working-group
#12
Alan E Greenberg, Christopher M Gordon, David W Purcell
No abstract text is available yet for this article.
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28079064/lasing-action-from-photonic-bound-states-in-continuum
#13
Ashok Kodigala, Thomas Lepetit, Qing Gu, Babak Bahari, Yeshaiahu Fainman, Boubacar Kanté
In 1929, only three years after the advent of quantum mechanics, von Neumann and Wigner showed that Schrödinger's equation can have bound states above the continuum threshold. These peculiar states, called bound states in the continuum (BICs), manifest themselves as resonances that do not decay. For several decades afterwards the idea lay dormant, regarded primarily as a mathematical curiosity. In 1977, Herrick and Stillinger revived interest in BICs when they suggested that BICs could be observed in semiconductor superlattices...
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28078610/optimization-of-the-return-to-sport-paradigm-after-anterior-cruciate-ligament-reconstruction-a-critical-step-back-to-move-forward
#14
REVIEW
Bart Dingenen, Alli Gokeler
Athletes who have sustained an anterior cruciate ligament (ACL) injury often opt for an ACL reconstruction (ACLR) with the goal and expectation to resume sports. Unfortunately, the proportion of athletes successfully returning to sport is relatively low, while the rate of second ACL injury has been reported to exceed 20% after clearance to return to sport, especially within younger athletic populations. Despite the development of return-to-sport guidelines over recent years, there are still more questions than answers on the most optimal return-to-sport criteria after ACLR...
January 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28078479/follow-up-cancer-care-perspectives-of-aboriginal-and-torres-strait-islander-cancer-survivors
#15
J A Meiklejohn, G Garvey, R Bailie, E Walpole, J Adams, D Williamson, J Martin, C M Bernardes, B Arley, B Marcusson, P C Valery
PURPOSE: The purpose of this study was to explore Indigenous Australian cancer survivors' perspectives of follow-up cancer care and management.. METHODS: This is a qualitative study employing individual interviews with 21 Indigenous cancer survivors (13 females, 8 males) recruited from a rural primary health service and large tertiary hospital in Brisbane, Queensland. Yarning methods were used to conduct semi-structured interviews. Yarning is a culturally appropriate, informal conversational process emphasising the importance of storytelling...
January 12, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28077232/evidence-for-underuse-of-effective-medical-services-around-the-world
#16
REVIEW
Paul Glasziou, Sharon Straus, Shannon Brownlee, Lyndal Trevena, Leonila Dans, Gordon Guyatt, Adam G Elshaug, Robert Janett, Vikas Saini
Underuse-the failure to use effective and affordable medical interventions-is common and responsible for substantial suffering, disability, and loss of life worldwide. Underuse occurs at every point along the treatment continuum, from populations lacking access to health care to inadequate supply of medical resources and labour, slow or partial uptake of innovations, and patients not accessing or declining them. The extent of underuse for different interventions varies by country, and is documented in countries of high, middle, and low-income, and across different types of health-care systems, payment models, and health services...
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28076970/future-directions-for-work-on-refinement-of-adhd-assessment-in-young-adults
#17
Michelle M Martel, Ulrich Schimmack, Joel T Nigg
Sibley, Coxe, and Molina provide a thoughtful discussion of the implications of our study and highlight important future directions in this line of work. They helpfully amplify several themes that space did not allow discussion of in our article. In particular, they correctly emphasize the importance of theoretical as well as statistical considerations in model selection. We also agree that clinical tests of sensitivity and specificity, taking into account different base rates and types of samples, are essential before a final algorithm would be ready for dissemination...
January 1, 2017: Assessment
https://www.readbyqxmd.com/read/28076397/when-viruses-don-t-go-viral-the-importance-of-host-phylogeographic-structure-in-the-spatial-spread-of-arenaviruses
#18
Sophie Gryseels, Stuart J E Baird, Benny Borremans, Rhodes Makundi, Herwig Leirs, Joëlle Goüy de Bellocq
Many emerging infections are RNA virus spillovers from animal reservoirs. Reservoir identification is necessary for predicting the geographic extent of infection risk, but rarely are taxonomic levels below the animal species considered as reservoir, and only key circumstances in nature and methodology allow intrinsic virus-host associations to be distinguished from simple geographic (co-)isolation. We sampled and genetically characterized in detail a contact zone of two subtaxa of the rodent Mastomys natalensis in Tanzania...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28075508/differences-in-access-to-and-use-of-electronic-personal-health-information-between-rural-and-urban-residents-in-the-united-states
#19
Alexandra J Greenberg, Danielle Haney, Kelly D Blake, Richard P Moser, Bradford W Hesse
PURPOSE: The increase in use of health information technologies (HIT) presents new opportunities for patient engagement and self-management. Patients in rural areas stand to benefit especially from increased access to health care tools and electronic communication with providers. We assessed the adoption of 4 HIT tools over time by rural or urban residency. METHODS: Analyses were conducted using data from 7 iterations of the National Cancer Institute's Health Information National Trends Survey (HINTS; 2003-2014)...
January 11, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28074948/hot-electron-driven-photocatalytic-water-splitting
#20
Bingya Hou, Lang Shen, Haotian Shi, Rehan Kapadia, Stephen B Cronin
We report measurements of photocatalytic water splitting using Au films with and without TiO2 coatings. In these structures, a thin (3-10 nm) film of TiO2 is deposited using atomic layer deposition (ALD) on top of a 100 nm thick Au film. We utilize an AC lock-in technique, which enables us to detect the relatively small photocurrents (∼μA) produced by the short-lived hot electrons that are photoexcited in the metal. Under illumination, the bare Au film produces a small AC photocurrent (<1 μA) for both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) due to hot electrons and hot holes, respectively, that are photoexcited in the Au film...
January 11, 2017: Physical Chemistry Chemical Physics: PCCP
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