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https://www.readbyqxmd.com/read/29793124/how-to-manage-patellofemoral-pain-understanding-the-multifactorial-nature-and-treatment-options
#1
Simon Lack, Bradley Neal, Danilo De Oliveira Silva, Christian Barton
Patellofemoral pain (PFP) is one of the most prevalent conditions within sports medicine, orthopaedic and general practice settings. Long-term treatment outcomes are poor, with estimates that more than 50% of people with the condition will report symptoms beyond 5 years following diagnosis. Additionally, emerging evidence indicates that PFP may be on a continuum with patellofemoral osteoarthritis. Consensus of world leading clinicians and academics highlights the potential benefit of delivering tailored interventions, specific to an individual's needs, to improve patient outcome...
April 12, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29792543/restructuring-saudi-board-in-restorative-dentistry-sbrd-curriculum-using-canmeds-competency
#2
Bahiah Abdulaziz Al Askar, Fahad Saleh Al Sweleh, Ebtesam Ibrahim Al Wasill, Zubair Amin
OBJECTIVE: The purpose of this paper is to describe the process of adopting the Canadian Medical Education Directions for Specialists (CanMEDS) 2015 competency framework in a dental specialty program to reconstruct the Saudi Board in Restorative Dentistry (SBRD) curriculum and disseminate the lessons learned. Method and development process: The process of curriculum development was started with the selection of SBRD curriculum committee and review of CanMEDS framework. The Committee conducted needs assessment among the stakeholders and adopted CanMEDS 2015 competencies through a careful process...
May 24, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29792432/new-basis-set-for-the-evaluation-of-specific-rotation-in-flexible-biological-molecules-in-solution
#3
Angelika Baranowska-Laczkowska, Krzysztof Z Łączkowski, Christian Henriksen, Berta Fernandez
A detailed theoretical investigation of specific rotation is carried out in solution for nine flexible molecules of biological importance. Systematic search for the main conformers is followed by time-dependent density functional theory (TD-DFT) calculations of specific rotation employing a wide range of basis sets. Due to conformational flexibility of the compounds under study, the possibility of basis set size reduction without deterioration of the results is investigated. The increasing size (d-)aug-cc-pVXZ (X=D, T, Q) bases of Dunning et al...
May 24, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29792340/multidisciplinary-care-model-for-hiv-improves-treatment-outcome-a-single-centre-experience-from-the-middle-east
#4
Ali Elgalib, Halima Al-Sawafi, Bina Kamble, Saud Al-Harthy, Qamra Al-Sariri
Multidisciplinary team (MDT) care models have been shown to improve clinical outcomes among HIV patients. We aim to assess the impact of adopting MDT approach in a tertiary HIV clinic in Muscat, Sultanate of Oman. We introduced MDT approach in our HIV centre in January 2016 where existing team members (counsellors, nurses, social workers, pharmacists and doctors) worked together, through care pathways, to support patients as they go through the HIV care continuum from diagnosis to viral suppression. Notes were reviewed for demographics and clinical data...
May 24, 2018: AIDS Care
https://www.readbyqxmd.com/read/29791859/combining-ngn2-programming-with-developmental-patterning-generates-human-excitatory-neurons-with-nmdar-mediated-synaptic-transmission
#5
Ralda Nehme, Emanuela Zuccaro, Sulagna Dia Ghosh, Chenchen Li, John L Sherwood, Olli Pietilainen, Lindy E Barrett, Francesco Limone, Kathleen A Worringer, Sravya Kommineni, Ying Zang, Davide Cacchiarelli, Alex Meissner, Rolf Adolfsson, Stephen Haggarty, Jon Madison, Matthias Muller, Paola Arlotta, Zhanyan Fu, Guoping Feng, Kevin Eggan
Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate human neurons for disease modeling. However, programming schemes produce a variety of cell types, and those neurons that are made often retain an immature phenotype, which limits their utility in modeling neuronal processes, including synaptic transmission. We report that combining NGN2 programming with SMAD and WNT inhibition generates human patterned induced neurons (hpiNs). Single-cell analyses showed that hpiN cultures contained cells along a developmental continuum, ranging from poorly differentiated neuronal progenitors to well-differentiated, excitatory glutamatergic neurons...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791436/the-genomic-landscape-at-a-late-stage-of-stickleback-speciation-high-genomic-divergence-interspersed-by-small-localized-regions-of-introgression
#6
Mark Ravinet, Kohta Yoshida, Shuji Shigenobu, Atsushi Toyoda, Asao Fujiyama, Jun Kitano
Speciation is a continuous process and analysis of species pairs at different stages of divergence provides insight into how it unfolds. Previous genomic studies on young species pairs have revealed peaks of divergence and heterogeneous genomic differentiation. Yet less known is how localised peaks of differentiation progress to genome-wide divergence during the later stages of speciation in the presence of persistent gene flow. Spanning the speciation continuum, stickleback species pairs are ideal for investigating how genomic divergence builds up during speciation...
May 23, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29790513/dynamics-in-a-one-dimensional-ferrogel-model-relaxation-pairing-shock-wave-propagation
#7
Segun Goh, Andreas M Menzel, Hartmut Löwen
Ferrogels are smart soft materials, consisting of a polymeric network and embedded magnetic particles. Novel phenomena, such as the variation of the overall mechanical properties by external magnetic fields, emerge consequently. However, the dynamic behavior of ferrogels remains largely unveiled. In this paper, we consider a one-dimensional chain consisting of magnetic dipoles and elastic springs between them as a simple model for ferrogels. The model is evaluated by corresponding simulations. To probe the dynamics theoretically, we investigate a continuum limit of the energy governing the system and the corresponding equation of motion...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29790442/closing-the-delivery-gap
#8
Kevin Peter Fiori, Jennifer Schechter, Sesso Christophe Gbeleou, Sandra Braganza, Joseph Rhatigan, Spero Houndenou, Andrew Lopez, Emily Bensen, Lisa Hirschhorn
Purpose The purpose of this paper is to describe the authors' experience operationalizing the care delivery value chain (CDVC) as a management and continuous quality improvement (QI) approach to strengthen HIV/AIDS services provided in Northern Togo through addressing gaps across a care continuum. Design/methodology/approach The authors led a series of discussions to develop a CDVC specific to existing HIV/AIDS services in Northern Togo. Using the CDVC framework, 28 specific gaps in service delivery were identified and integrated into a strategic QI plan...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29790413/specific-language-impairment-and-reading-disability-categorical-distinction-or-continuum
#9
George C Spanoudis, Timothy C Papadopoulos, Spyroula Spyrou
Specific language impairment (SLI) and reading disability (RD) are familial, moderately heritable comorbid developmental disorders. The key deficit of SLI is oral language, whereas children with RD exhibit impairment in learning to read. The present study examines the possible co-occurrence of RD and SLI and the nature of this co-occurrence at a linguistic and a cognitive level in an orthographically consistent language. Four groups of children participated in the study: an RD group ( n = 10), an SLI group ( n = 13), a possible comorbid group ( n = 9), and a control-no deficit group ( n = 20)...
May 1, 2018: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/29789492/a-continuum-model-for-the-effect-of-dynamic-recrystallization-on-the-stress%C3%A2-strain-response
#10
H Kooiker, E S Perdahcıoğlu, A H van den Boogaard
Austenitic Stainless Steels and High-Strength Low-Alloy (HSLA) steels show significant dynamic recovery and dynamic recrystallization (DRX) during hot forming. In order to design optimal and safe hot-formed products, a good understanding and constitutive description of the material behavior is vital. A new continuum model is presented and validated on a wide range of deformation conditions including high strain rate deformation. The model is presented in rate form to allow for the prediction of material behavior in transient process conditions...
May 22, 2018: Materials
https://www.readbyqxmd.com/read/29789126/a-comprehensive-review-on-self-healing-of-asphalt-materials-mechanism-model-characterization-and-enhancement
#11
REVIEW
Daquan Sun, Guoqiang Sun, Xingyi Zhu, Alvaro Guarin, Bin Li, Ziwei Dai, Jianming Ling
Self-healing has great potential to extend the service life of asphalt pavement, and this capability has been regarded as an important strategy when designing a sustainable infrastructure. This review presents a comprehensive summary of the state-of-the-art investigations concerning the self-healing mechanism, model, characterization and enhancement, ranging from asphalt to asphalt pavement. Firstly, the self-healing phenomenon as a general concept in asphalt materials is analyzed including its definition and the differences among self-healing and some viscoelastic responses...
May 9, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29788771/understanding-design-vulnerabilities-in-the-physical-environment-relating-to-patient-fall-patterns-in-a-psychiatric-hospital-seven-years-of-sentinel-events
#12
Sara Bayramzadeh, Margaret Portillo, Candy Carmel-Gilfilen
BACKGROUND: The influence of the physical environment on patient falls has not been fully explored in psychiatric units, despite this patient population's vulnerability and the critical role of the physical environment in patient safety. AIMS: The research objective is to describe the spatial and temporal pattern of falls occurrences and their location in relation to the levels of safety continuum model. METHOD: This article presents an exploratory case study design...
May 1, 2018: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/29788756/correlates-of-frequent-gambling-and-gambling-related-chasing-behaviors-in-individuals-with-schizophrenia-spectrum-disorders
#13
Igor Yakovenko, Rebecca Fortgang, Jennifer Prentice, Rani A Hoff, Marc N Potenza
Background and aims Published research on the relationship between disordered gambling and schizophrenia is limited. However, existing data suggest that individuals with schizophrenia/schizoaffective disorder may have a high prevalence of co-occurring disordered gambling. As such, effective strategies for screening and assessing gambling-related problems in individuals with psychosis are needed. The goal of this study was to explore the correlates of increased gambling frequency and chasing behavior, a hallmark feature of gambling disorder, in a sample of individuals with schizophrenia and schizoaffective disorders...
May 23, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29788313/defining-value-of-cancer-therapeutics-a-health-system-perspective
#14
Christine Leopold, Jeffrey M Peppercorn, S Yousuf Zafar, Anita K Wagner
Because of the rising costs of cancer care and ongoing challenges in ensuring access to quality care, there is an increasing need to prioritize spending and define the benefits of therapy in proportion to costs. The term "value" has gained favor as means to define the relative utility of a medical intervention in terms of benefits, risks, and financial costs, which in turn can help clinicians, patients, and policy makers prioritize "high-value" care. While numerous value concepts have been proposed, a comprehensive discussion of value initiatives along the care continuum is missing...
May 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29787580/risk-behaviors-and-hiv-care-continuum-outcomes-among-criminal-justice-involved-hiv-infected-transgender-women-and-cisgender-men-data-from-the-seek-test-treat-and-retain-harmonization-initiative
#15
Curt G Beckwith, Irene Kuo, Rob J Fredericksen, Lauren Brinkley-Rubinstein, William E Cunningham, Sandra A Springer, Kelsey B Loeliger, Julie Franks, Katerina Christopoulos, Jennifer Lorvick, Shoshana Y Kahana, Rebekah Young, David W Seal, Chad Zawitz, Joseph A Delaney, Heidi M Crane, Mary L Biggs
BACKGROUND: Transgender persons are highly victimized, marginalized, disproportionately experience incarceration, and have alarmingly increased rates of HIV infection compared to cis-gender persons. Few studies have examined the HIV care continuum outcomes among transgender women (TW), particularly TW who are involved with the criminal justice (CJ) system. METHODS: To improve our understanding of HIV care continuum outcomes and risk behaviors among HIV-infected TW who are involved with the CJ system, we analyzed data from the National Institute on Drug Abuse-supported Seek, Test, Treat, Retain (STTR) Data Harmonization Initiative...
2018: PloS One
https://www.readbyqxmd.com/read/29787458/peer-teaching-in-high-fidelity-simulation-participant-experiences-and-reflections
#16
Kay Lawrence, DeAnne K Hilfinger Messias, Robin Dawson Estrada, Vicki Long
Peer teaching provides students with opportunities to experience the educator role and increase self-confidence and problem-solving skills. To address the shortage of meaningful leadership experiences for senior baccalaureate nursing students, faculty implemented an alternative leadership experience involving senior students taking on the role of peer teachers in the high-fidelity simulation (HFS) laboratory. We conducted focus groups to assess peer teachers and learners' experiences and used thematic analysis to examine and interpret the data...
May 9, 2018: Nurse Educator
https://www.readbyqxmd.com/read/29786613/biophysics-of-membrane-curvature-remodeling-at-molecular-and-mesoscopic-lengthscales
#17
Natesan Ramakrishnan, Ryan P Bradley, Richard W Tourdot, Ravi Radhakrishnan
At the micron scale, where cell organelles display an amazing complexity in their shape and organization, the physical properties of a biological membrane can be better-understood using continuum models subject to thermal (stochastic) undulations. Yet, the chief orchestrators of these complex and intriguing shapes are a specialized class of membrane associating often peripheral proteins called curvature remodeling proteins (CRPs) that operate at the molecular level through specific protein-lipid interactions...
May 22, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29785890/family-networks-and-healthy-behaviour-evidence-from-nepal
#18
Jolene Skordis, Noemi Pace, Marcos Vera-Hernandez, Imran Rasul, Emla Fitzsimons, David Osrin, Dharma Manandhar, Anthony Costello
Models of household decision-making commonly focus on nuclear family members as primary decision-makers. If extended families shape the objectives and constraints of households, then neglecting the role of this network may lead to an incomplete understanding of health-seeking behaviour. Understanding the decision-making processes behind care-seeking may improve behaviour change interventions, better intervention targeting and support health-related development goals. This paper uses data from a cluster randomised trial of a participatory learning and action cycle (PLA) through women's groups, to assess the role of extended family networks as a determinant of gains in health knowledge and health practice...
May 22, 2018: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/29783766/finite-element-analysis-of-electrospun-nanofibrous-mats-under-biaxial-tension
#19
Yunlei Yin, Jie Xiong
Due to the non-uniform material properties of electrospun nanofibrous mats and the non-linear characteristics of single fibers, establishing a numerical model that can fully explain these features and correctly describe their properties is difficult. Based on the microstructure of electrospun nanofibrous mats, two macroscopic continuum finite element (FE) models with a uniform or oriented nanofiber distribution were established to describe the mechanical behavior of nanofibrous mats under biaxial tension. The FE models were verified by biaxial tension experiments on silk fibroin/polycaprolactone nanofibrous mats...
May 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783057/evaluation-of-water-relation-parameters-in-vitis-rootstocks-with-different-drought-tolerance-and-their-effects-on-growth-of-a-grafted-cultivar
#20
Gregorio Gullo, Antonio Dattola, Vincenzo Vonella, Rocco Zappia
Knowledge of root hydraulic resistance will allow us to better understand water relations arising in the soil-plant-atmosphere continuum. These are the basis for better control of plant behaviour in the current environmental context that is more and more affected by global warming and problems related to increased drought frequency and duration. The objectives of this study were to determine how the growth of a cultivar changes in response to the drought tolerance of the rootstock used in Vitis grown in a semi-arid area and how the root hydraulic resistivity and root hydraulic conductivity change with increased transpiration when adopting a rootstock with a different drought tolerance...
April 27, 2018: Journal of Plant Physiology
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