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ustekinumab

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https://www.readbyqxmd.com/read/28207934/role-of-hla-c-06-in-clinical-response-to-ustekinumab-evidence-from-real-life-in-a-large-cohort-of-european-patients
#1
M Talamonti, M Galluzzo, J M van den Reek, E M de Jong, J L W Lambert, P Malagoli, L Bianchi, A Costanzo
BACKGROUND: Little is known about role of HLA-C*06 related to response to psoriasis treatments. OBJECTIVES: This study that involved four European centres aims to confirm the role of HLA-C*06 in a new large cohort of patients, as a pharmacogenetic marker of response to ustekinumab. METHODS: In this retrospective multicenter study we reviewed data of 255 psoriasis patients genotyped for HLA-C*06, which have started ustekinumab treatment between January 2014 and March 2015...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28205212/sarcoidosis-extent-relates-to-molecular-variability
#2
Calixte S Monast, Katherine Li, Marc A Judson, Robert P Baughman, Eric Wadman, Rosemary Watt, Philip E Silkoff, Elliot S Barnathan, Carrie Brodmerkel
The molecular basis of sarcoidosis phenotype heterogeneity and its relationship to effective treatment of sarcoidosis have not been elucidated. Peripheral samples from sarcoidosis subjects who participated in a phase 2 study of golimumab (anti-TNFα) and ustekinumab (anti-IL12p40) were used to measure the whole blood transcriptome and levels of serum proteins. Differential gene and protein expression analyses were used to explore the molecular differences between sarcoidosis phenotypes as defined by extent of organ involvement...
February 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28204858/-ustekinumab-for-the-treatment-of-crohn-s-disease-uniti-im-uniti
#3
B Siegmund, S Nitschmann
No abstract text is available yet for this article.
February 15, 2017: Der Internist
https://www.readbyqxmd.com/read/28202422/clearance-of-annular-pustular-psoriasis-with-ustekinumab
#4
Viktor Schnabel, Sigrid M C Broekaert, Michael P Schön, Rotraut Mössner
No abstract text is available yet for this article.
February 15, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28199485/successful-treatment-with-ustekinumab-for-chronic-refractory-pouchitis
#5
My-Linh Tran-Minh, Matthieu Allez, Jean-Marc Gornet
No abstract text is available yet for this article.
February 11, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28197884/therapies-of-early-advanced-and-late-onset-forms-of-axial-spondyloarthritis-and-the-need-for-treat-to-target-strategies
#6
REVIEW
Nurullah Akkoc, Gercek Can, Salvatore D'Angelo, Angela Padula, Ignazio Olivieri
PURPOSE OF REVIEW: This study aims to provide an update on current status of pharmacological therapies in early and advanced stages of axial spondyloarthritis (axSpA), as well as its late onset forms, and to discuss the need for treat to target strategies in this entity. RECENT FINDINGS: Efficacy of TNF inhibitors has been assessed in randomized controlled trials in axSpA, which included patients who had non-radiographic axSpA according to the ASAS classification criteria...
February 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28191663/a-case-of-lupus-like-syndrome-in-a-patient-receiving-adalimumab-and-a-brief-review-of-the-literature-on-drug-induced-lupus-erythematosus
#7
I Lomicová, D Suchý, K Pizinger, P Cetkovská
WHAT IS KNOWN AND OBJECTIVE: Drug-induced lupus erythematosus occurs with some drugs and resolves with their withdrawal. Anti-TNF therapies have been found to be associated with a lupus-like syndrome, which is clinically distinct from classical drug-induced as well as idiopathic lupus erythematosus. CASE DESCRIPTION: We describe a case of a patient with severe psoriasis, who developed muscle pain with paraesthesia accompanied by ANA titres elevation with adalimumab treatment...
February 12, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28179246/legionella-pneumophila-pneumonia-possibly-due-to-ustekinumab-therapy-in-a-patient-with-crohn-s-disease
#8
Joaquín Borrás-Blasco, Xavier Cortes, Sergio Fernandez-Martinez, Elvira Casterá, Beatriz Antequera
PURPOSE: A case report of Legionella pneumophila pneumonia associated with off-label use of ustekinumab in a patient with Crohn's disease (CD) is presented. SUMMARY: A 57-year-old man with longstanding CD was hospitalized with a four-day history of fever (38.5 °C), dyspnea, left pleuritic pain, and weight loss (more than 6 kg) about six weeks after beginning treatment with ustekinumab, a human monoclonal antibody approved in the United States for two indications (plaque psoriasis and psoriatic arthritis) and currently under investigation as a potential treatment for CD and other inflammatory disorders...
February 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28176964/efficacy-and-safety-of-biological-and-targeted-synthetic-dmards-a-systematic-literature-review-informing-the-2016-update-of-the-asas-eular-recommendations-for-the-management-of-axial-spondyloarthritis
#9
Alexandre Sepriano, Andrea Regel, Désirée van der Heijde, Jürgen Braun, Xenofon Baraliakos, Robert Landewé, Filip Van den Bosch, Louise Falzon, Sofia Ramiro
OBJECTIVES: To update the evidence for the efficacy and safety of (b)biological and (ts)targeted-synthetic disease-modifying anti-rheumatic drugs (DMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2016 update of the Assessment of SpondyloArthritis international Society/European League Against Rheumatism (ASAS/EULAR) recommendations for the management of axSpA. METHODS: Systematic literature review (2009-2016) for randomised controlled trials (RCT), including long-term extensions, strategy trials and observational studies (the latter was only for safety assessment and a comparator was required)...
2017: RMD Open
https://www.readbyqxmd.com/read/28175164/p594-ustekinumab-treatment-effectiveness-in-clinical-practice-a-multicentre-retrospective-review-of-long-term-outcomes-in-crohn-s-disease
#10
C R Rowan, A Alakkari, C Moran, J O'Connell, G Cullen, H Mulcahy, C O'Morain, D McNamara, J Leyden, P MacMathuna, A O'Toole, S Patchett, S McKiernan, D Kevans, G A Doherty, B Ryan
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175158/p626-ustekinumab-for-the-treatment-of-perianal-fistulas-in-patients-with-crohn-s-disease
#11
R Battat, T Bessissow, M Strohl, U Kopylov, A Bitton, A Cohen, E Seidman, W Afif
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175147/p549-effect-of-maintenance-ustekinumab-on-corticosteroid-free-clinical-outcomes-in-patients-with-crohn-s-disease
#12
B G Feagan, C Gasink, P Pollack, D Jacobstein, L-L Gao, J Johanns, Y Miao, S Targan, S Ghosh
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175098/p360-trough-levels-and-antibodies-to-ustekinumab-are-not-correlated-to-response-to-ustekinumab-treatment-in-crohn-s-disease-patients
#13
P Claire, B Severine, D Nicolas, N Maria, D Pierre, B Julien, G Romain, B Medina, L Myriam, P Benjamin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174962/dop053-the-fecal-microbiome-as-a-tool-for-monitoring-and-predicting-response-outcomes-in-ustekinumab-treated-anti-tnf%C3%AE-refractory-crohn-s-disease-patients-results-from-the-certifi-study
#14
M K Doherty, C Koumpouras, S E Telesco, C Monast, C Brodmerkel, P D Schloss
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174941/dop052-molecular-response-to-ustekinumab-in-moderate-to-severe-crohn-s-disease-by-serum-protein-and-biopsy-gene-expression-analysis-results-from-ustekinumab-phase-3-studies
#15
K Li, K Hayden, E Wadman, S Bhagat, S Emrich, D Jacobstein, C Gasink, C Brodmerkel
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174928/dop046-genome-wide-association-study-of-baseline-disease-characteristics-and-response-to-ustekinumab-in-moderate-to-severe-crohn-s-disease
#16
A Hart, K Li, C Gasink, D Jacobstein, C Brodmerkel
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174927/dop027-long-term-efficacy-and-safety-of-ustekinumab-in-refractory-crohn-s-disease-patients-a-multicenter-retrospective-experience
#17
P Wils, Y Bouhnik, P Michetti, B Flourie, H Brixi, A Bourrier, M Allez, B Duclos, M Serrero, A Buisson, A Amiot, M Fumery, X Roblin, L Peyrin-Biroulet, J Filippi, G Bouguen, V Abitbol, B Coffin, M Simon, D Laharie, B Pariente
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173013/p597-ustekinumab-use-in-crohn-s-disease-a-tertiary-centre-experience
#18
A Greenup, G Rosenfeld, B Bressler
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173002/p640-serum-ustekinumab-levels-achieved-with-a-subcutaneous-induction-regimen-correlate-to-clinical-outcome-a-prospective-study
#19
C R Rowan, A Kalei, A De Vries, G Cullen, E Ryan, H Mulcahy, G D'Haens, G A Doherty
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172810/p625-ustekinumab-use-in-crohn-s-disease-effectiveness-of-dose-escalation
#20
A Greenup, G Rosenfeld, B Bressler
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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