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https://www.readbyqxmd.com/read/29153572/prognostic-value-of-quantitative-stress-perfusion-cardiac-magnetic-resonance
#1
Eva C Sammut, Adriana D M Villa, Gabriella Di Giovine, Luke Dancy, Filippo Bosio, Thomas Gibbs, Swarna Jeyabraba, Susanne Schwenke, Steven E Williams, Michael Marber, Khaled Alfakih, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
OBJECTIVES: This study sought to evaluate the prognostic usefulness of visual and quantitative perfusion cardiac magnetic resonance (CMR) ischemic burden in an unselected group of patients and to assess the validity of consensus-based ischemic burden thresholds extrapolated from nuclear studies. BACKGROUND: There are limited data on the prognostic value of assessing myocardial ischemic burden by CMR, and there are none using quantitative perfusion analysis. METHODS: Patients with suspected coronary artery disease referred for adenosine-stress perfusion CMR were included (n = 395; 70% male; age 58 ± 13 years)...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29138394/critical-mutation-rate-has-an-exponential-dependence-on-population-size-for-eukaryotic-length-genomes-with-crossover
#2
Elizabeth Aston, Alastair Channon, Roman V Belavkin, Danna R Gifford, Rok Krašovec, Christopher G Knight
The critical mutation rate (CMR) determines the shift between survival-of-the-fittest and survival of individuals with greater mutational robustness ("flattest"). We identify an inverse relationship between CMR and sequence length in an in silico system with a two-peak fitness landscape; CMR decreases to no more than five orders of magnitude above estimates of eukaryotic per base mutation rate. We confirm the CMR reduces exponentially at low population sizes, irrespective of peak radius and distance, and increases with the number of genetic crossovers...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127185/advances-in-computational-modelling-for-personalised-medicine-after-myocardial-infarction
#3
REVIEW
Kenneth Mangion, Hao Gao, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment...
November 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29119275/comparison-of-effects-of-losartan-and-metoprolol-on-left-ventricular-and-aortic-function-at-rest-and-during-exercise-in-chronic-aortic-regurgitation
#4
Paul A Roberts, Aaron C W Lin, Brett R Cowan, Alistair A Young, Ralph Stewart
Aortic regurgitation (AR) increases the hemodynamic load on both the left ventricle (LV) and the aorta. Vasodilators and beta-blockers both reduce systemic blood pressure, but their relative effects on the LV and aortic function and aortic regurgitant fraction in chronic AR are uncertain. We aimed to compare short-term effects of losartan and metoprolol on LV and aortic function in asymptomatic patients with chronic moderate to severe AR, both at rest and during exercise, using cardiac magnetic resonance (CMR) imaging...
November 8, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29119262/role-of-cardiac-pet-in-clinical-practice
#5
REVIEW
Brian M Salata, Parmanand Singh
Early identification of atherosclerosis and at-risk lesions plays a critical role in reducing the burden of cardiovascular disease. While invasive coronary angiography serves as the gold standard for diagnosing coronary artery disease, non-invasive imaging techniques provide visualization of both anatomical and functional atherosclerotic processes prior to clinical presentation. The development of cardiac positron emission tomography (PET) has greatly enhanced our capability to diagnose and treat patients with early stages of atherosclerosis...
November 9, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29110669/a-comparison-of-cardiovascular-magnetic-resonance-and-single-photon-emission-computed-tomography-spect-perfusion-imaging-in-left-main-stem-or-equivalent-coronary-artery-disease-a-ce-marc-substudy
#6
James R J Foley, Ananth Kidambi, John D Biglands, Neil Maredia, Catherine J Dickinson, Sven Plein, John P Greenwood
BACKGROUND: Assessment of left main stem (LMS) stenosis has prognostic and therapeutic implications. Data on assessment of LMS disease by cardiovascular magnetic resonance (CMR) and single photon emission computed tomography (SPECT) are limited. CE-MARC is the largest prospective comparison of CMR and SPECT against quantitative invasive coronary angiography (QCA) for detection of coronary artery disease (CAD), and provided the framework for this evaluation. The aims of this study were to compare diagnostic accuracy of visual and quantitative perfusion CMR to SPECT in patients with LMS stable CAD...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29080955/fusion-of-ct-coronary-angiography-and-whole-heart-dynamic-3d-cardiac-mr-perfusion-building-a-framework-for-comprehensive-cardiac-imaging
#7
Jochen von Spiczak, Robert Manka, Alexander Gotschy, Sabrina Oebel, Sebastian Kozerke, Sandra Hamada, Hatem Alkadhi
The purpose of this work was to develop a framework for 3D fusion of CT coronary angiography (CTCA) and whole-heart dynamic 3D cardiac magnetic resonance perfusion (3D-CMR-Perf) image data-correlating coronary artery stenoses to stress-induced myocardial perfusion deficits for the assessment of coronary artery disease (CAD). Twenty-three patients who underwent CTCA and 3D-CMR-Perf for various indications were included retrospectively. For CTCA, image quality and coronary diameter stenoses > 50% were documented...
October 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29070069/adenosine-stress-cmr-t1-mapping-detects-early-microvascular-dysfunction-in-patients-with-type-2-diabetes-mellitus-without-obstructive-coronary-artery-disease
#8
Eylem Levelt, Stefan K Piechnik, Alexander Liu, Rohan S Wijesurendra, Masliza Mahmod, Rina Ariga, Jane M Francis, Andreas Greiser, Kieran Clarke, Stefan Neubauer, Vanessa M Ferreira, Theodoros D Karamitsos
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with coronary microvascular dysfunction in the absence of obstructive coronary artery disease (CAD). Cardiovascular magnetic resonance (CMR) T1-mapping at rest and during adenosine stress can assess coronary vascular reactivity. We hypothesised that the non-contrast T1 response to vasodilator stress will be altered in patients with T2DM without CAD compared to controls due to coronary microvascular dysfunction. METHODS: Thirty-one patients with T2DM and sixteen matched healthy controls underwent CMR (3 T) for cine, rest and adenosine stress non-contrast T1-mapping (ShMOLLI), first-pass perfusion and late gadolinium enhancement (LGE) imaging...
October 25, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29063953/magnetic-resonance-myocardial-perfusion-imaging-safety-and-indications-in-pediatrics-and-young-adults
#9
David M Biko, R Thomas Collins, Sara L Partington, Matthew Harris, Kevin K Whitehead, Marc S Keller, Mark A Fogel
The purpose of this study was to assess the safety and indications for cardiac magnetic resonance (CMR) with myocardial perfusion imaging (MPI) in a cohort of children and young adults. A retrospective review of 178 children and young adults who underwent CMR with MPI was performed. Studies were categorized based on study protocols as MPI with resting perfusion only, adenosine stress MPI, exercise-induced stress MPI, and MPI for cardiac mass diagnosis. Relevant clinical history, exam indications, and adverse reactions following gadolinium-based contrast agent and adenosine administration were recorded...
October 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29047385/fully-quantitative-cardiovascular-magnetic-resonance-myocardial-perfusion-ready-for-clinical-use-a-comparison-between-cardiovascular-magnetic-resonance-imaging-and-positron-emission-tomography
#10
Henrik Engblom, Hui Xue, Shahnaz Akil, Marcus Carlsson, Cecilia Hindorf, Jenny Oddstig, Fredrik Hedeer, Michael S Hansen, Anthony H Aletras, Peter Kellman, Håkan Arheden
BACKGROUND: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow...
October 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29027633/multi-modality-imaging-in-the-evaluation-and-treatment-of-mitral-regurgitation
#11
REVIEW
Marc-André Bouchard, Claudia Côté-Laroche, Jonathan Beaudoin
Mitral regurgitation (MR) is frequent and associated with increased mortality and morbidity when severe. It may be caused by intrinsic valvular disease (primary MR) or ventricular deformation (secondary MR). Imaging has a critical role to document the severity, mechanism, and impact of MR on heart function as selected patients with MR may benefit from surgery whereas other will not. In patients planned for a surgical intervention, imaging is also important to select candidates for mitral valve (MV) repair over replacement and to predict surgical success...
October 13, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28984890/multi-centre-study-of-whole-heart-dynamic-3d-cardiac-magnetic-resonance-perfusion-imaging-for-the-detection-of-coronary-artery-disease-defined-by-fractional-flow-reserve-gender-based-analysis-of-diagnostic-performance
#12
Sandra Hamada, Alexander Gotschy, Lukas Wissmann, Ingo Paetsch, Cosima Jahnke, Sven Plein, Rolf Gebker, Sabrina Oebel, Hatem Alkadhi, Nikolaus Marx, Thomas F Lüscher, Sebastian Kozerke, Robert Manka
Aims: Coronary artery disease (CAD) is a leading cause of morbidity and mortality in women and non-invasive testing for CAD in women can be more challenging than in men. This study compared the diagnostic performance of whole-heart dynamic 3D cardiovascular magnetic resonance (CMR) stress perfusion imaging in female and male patients with quantitative coronary angiography (QCA) and fractional flow reserve (FFR) as reference tests. Methods and results: Four hundred sixteen patients with suspected or known CAD were enrolled in five European centres...
October 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28942735/representation-of-cardiovascular-magnetic-resonance-in-the-aha-acc-guidelines
#13
Florian von Knobelsdorff-Brenkenhoff, Guenter Pilz, Jeanette Schulz-Menger
BACKGROUND: Whereas evidence supporting the diagnostic value of cardiovascular magnetic resonance (CMR) has increased, there exists significant worldwide variability in the clinical utilization of CMR. A recent study demonstrated that CMR is represented in the majority of European Society for Cardiology (ESC) guidelines, with a large number of specific recommendations in particular regarding coronary artery disease. To further investigate the gap between the evidence and clinical use of CMR, this study analyzed the role of CMR in the guidelines of the American College of Cardiology (ACC) and American Heart Association (AHA)...
September 25, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28856412/accurate-late-gadolinium-enhancement-prediction-by-early-t1-based-quantitative-synthetic-mapping
#14
Randy van Dijk, Dirkjan Kuijpers, Theodorus A M Kaandorp, Paul R M van Dijkman, Rozemarijn Vliegenthart, Pim van der Harst, Matthijs Oudkerk
OBJECTIVES: Early synthetic gadolinium enhancement (ESGE) imaging from post-contrast T1 mapping after adenosine stress-perfusion cardiac magnetic resonance (CMR) was compared to conventional late gadolinium enhancement (LGE) imaging for assessing myocardial scar. METHODS: Two hundred fourteen consecutive patients suspected of myocardial ischaemia were referred for stress-perfusion CMR. Myocardial infarct volume was quantified on a per-subsegment basis in both synthetic (2-3 min post-gadolinium) and conventional (9 min post-gadolinium) images by two independent observers...
August 30, 2017: European Radiology
https://www.readbyqxmd.com/read/28844869/what-is-the-optimal-anatomic-location-for-coronary-artery-pressure-measurement-at-ct-derived-ffr
#15
Mateusz Solecki, Mariusz Kruk, Marcin Demkow, U Joseph Schoepf, Michael A Reynolds, Łukasz Wardziak, Zofia Dzielińska, Mateusz Śpiewak, Barbara Miłosz-Wieczorek, Łukasz Małek, Magdalena Marczak, Cezary Kępka
BACKGROUND: CT-FFR is an area of growing interest in the field of cardiac imaging. However, the specific anatomic location distal to a lesion of interest where CT-FFR should be computed to yield the most valid results has not been examined. This study investigated the most appropriate anatomic location distal to a coronary artery stenosis for obtaining CT-FFR measurements. METHODS: 73 patients (60 ± 9 years; 58% male) with at least one coronary lesion with 40-90% stenosis on coronary CTA (either a 2 × 128 slice or a 2 × 192 slice dual-source CT scanner) underwent stress cardiac magnetic resonance (CMR) perfusion imaging for inducible ischemia...
August 15, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28797357/stress-perfusion-coronary-flow-reserve-versus-cardiac-magnetic-resonance-for-known%C3%A2-or%C3%A2-suspected-cad
#16
Shingo Kato, Naka Saito, Tatsuya Nakachi, Kazuki Fukui, Tae Iwasawa, Masataka Taguri, Masami Kosuge, Kazuo Kimura
BACKGROUND: Phase-contrast (PC) cine magnetic resonance imaging (MRI) of the coronary sinus is a noninvasive method to quantify coronary flow reserve (CFR). OBJECTIVES: This study sought to compare the prognostic value of CFR by cardiac magnetic resonance (CMR) and stress perfusion CMR to predict major adverse cardiac events (MACE). METHODS: Participants included 276 patients with known coronary artery disease (CAD) and 400 with suspected CAD...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28754155/magnetic-resonance-adenosine-perfusion-imaging-as-gatekeeper-of-invasive-coronary-intervention-magnet-study-protocol-for-a-randomized-controlled-trial
#17
Dominik Buckert, Simon Witzel, Maciej Cieslik, Raid Tibi, Wolfgang Rottbauer, Peter Bernhardt
BACKGROUND: Current guidelines for the diagnosis and management of patients with stable coronary artery disease (CAD) recommend functional stress testing for risk stratification prior to revascularization procedures. Cardiac magnetic resonance imaging (CMR) is a modality of choice for stress testing because of its capability to detect myocardial ischemia sensitively and specifically. Nevertheless, evidence from randomized trials evaluating a CMR-based management of stable CAD patients in comparison to a more common angiography-based approach still is limited...
July 28, 2017: Trials
https://www.readbyqxmd.com/read/28735783/myocardial-viability-state-of-the-art-is-it-still-relevant-and-how-to-best-assess-it-with-imaging
#18
REVIEW
Hena Patel, Wojciech Mazur, Kim Allan Williams, Dinesh K Kalra
Despite major advances, ischemic cardiomyopathy (ICM) remains a significant cause of death and disability worldwide, with coronary artery disease (CAD) the leading cause of left ventricular (LV) systolic dysfunction. Coronary revascularization may improve LV function, heart failure symptoms and cardiovascular outcomes in high-risk patients with myocardial viability. Multiple imaging modalities have been utilized to detect viable myocardium and predict functional recovery following revascularization. Dobutamine stress echocardiography (DSE), nuclear imaging and cardiac MRI (CMR) are frequently used to assess viability...
July 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28733074/non-invasive-assessment-of-microvascular-dysfunction-in-patients-with-microvascular-angina
#19
Caroline Jaarsma, Hans Vink, Judith van Haare, Sebastiaan C A M Bekkers, Bart D van Rooijen, Walter H Backes, Joachim E Wildberger, Harry J Crijns, Jurgen van Teeffelen, Simon Schalla
BACKGROUND: We aimed to evaluate the microvascular function in patients with microvascular angina (MVA) by assessing 1) the endothelial glycocalyx barrier properties using sublingual microscopy, and 2) the myocardial perfusion reserve using cardiovascular magnetic resonance (CMR) imaging. METHODS: Sublingual microscopy was performed in 13 MVA patients (angina pectoris, ST-depression on treadmill testing, normal coronary angiogram) and compared with 2 control groups of 13 volunteers and 14 patients with known obstructive coronary artery disease (CAD)...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28712562/abnormal-right-atrial-performance-in-repaired-tetralogy-of-fallot-a-cmr-feature-tracking-analysis
#20
Shelby Kutty, Quanliang Shang, Navya Joseph, Johannes T Kowallick, Andreas Schuster, Michael Steinmetz, David A Danford, Phillip Beerbaum, Samir Sarikouch
BACKGROUND: We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). METHODS: TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF)...
December 1, 2017: International Journal of Cardiology
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