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https://www.readbyqxmd.com/read/28712562/abnormal-right-atrial-performance-in-repaired-tetralogy-of-fallot-a-cmr-feature-tracking-analysis
#1
Shelby Kutty, Quanliang Shang, Navya Joseph, Johannes T Kowallick, Andreas Schuster, Michael Steinmetz, David A Danford, Phillip Beerbaum, Samir Sarikouch
BACKGROUND: We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). METHODS: TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF)...
July 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28707599/designing-of-selective-%C3%AE-secretase-inhibitory-benzenesulfonamides-through-comparative-in-vitro-and-in-silico-analysis
#2
Neeraj Masand, Satya P Gupta, Ratan Lal Khosa
BACKGROUND: In Alzheimer's disease (AD), the gene mutations have been identified in the amyloid precursor protein (APP), the presenilin-1 (PS1) and -2 (PS2) genes. APP is a transmembrane protein which gets cleaved by α- and β-secretase enzymes and releases Aβ peptides which forms senile plaques in brain tissue. It contributes for local inflammatory response, subsequent oxidative stress, biochemical changes and neuronal death. Targeting the development of Aβ aggregates in the senile plaques is an important strategy in the treatment of AD...
July 13, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28694784/4d-flow-analysis-of-bav-related-fluid-dynamic-alterations-evidences-of-wall-shear-stress-alterations-in-absence-of-clinically-relevant-aortic-anatomical-remodeling
#3
Filippo Piatti, Francesco Sturla, Malenka M Bissell, Selene Pirola, Massimo Lombardi, Igor Nesteruk, Alessandro Della Corte, Alberto C L Redaelli, Emiliano Votta
Bicuspid aortic valve (BAV) is the most common congenital cardiac disease and is a foremost risk factor for aortopathies. Despite the genetic basis of BAV and of the associated aortopathies, BAV-related alterations in aortic fluid-dynamics, and particularly in wall shear stresses (WSSs), likely play a role in the progression of aortopathy, and may contribute to its pathogenesis. To test whether WSS may trigger aortopathy, in this study we used 4D Flow sequences of phase-contrast cardiac magnetic resonance imaging (CMR) to quantitatively compare the in vivo fluid dynamics in the thoracic aorta of two groups of subjects: (i) five prospectively enrolled young patients with normo-functional BAV and with no aortic dilation and (ii) ten age-matched healthy volunteers...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28679397/local-coronary-wall-eccentricity-and-endothelial-function-are-closely-related-in-patients-with-atherosclerotic-coronary-artery-disease
#4
Allison G Hays, Micaela Iantorno, Michael Schär, Monica Mukherjee, Matthias Stuber, Gary Gerstenblith, Robert G Weiss
BACKGROUND: Coronary endothelial function (CEF) in patients with coronary artery disease (CAD) varies among coronary segments in a given patient. Because both coronary vessel wall eccentricity and coronary endothelial dysfunction are predictors of adverse outcomes, we hypothesized that local coronary endothelial dysfunction is associated with local coronary artery eccentricity. METHODS: We used 3 T coronary CMR to measure CEF as changes in coronary cross-sectional area (CSA) and coronary blood flow (CBF) during isometric handgrip exercise (IHE), a known endothelial-dependent stressor, in 29 patients with known CAD and 16 healthy subjects...
July 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28637508/hyperpolarized-13-c-urea-myocardial-first-pass-perfusion-imaging-using-velocity-selective-excitation
#5
Maximilian Fuetterer, Julia Busch, Sophie M Peereboom, Constantin von Deuster, Lukas Wissmann, Miriam Lipiski, Thea Fleischmann, Nikola Cesarovic, Christian T Stoeck, Sebastian Kozerke
BACKGROUND: A velocity-selective binomial excitation scheme for myocardial first-pass perfusion measurements with hyperpolarized (13)C substrates, which preserves bolus magnetization inside the blood pool, is presented. The proposed method is evaluated against gadolinium-enhanced (1)H measurements in-vivo. METHODS: The proposed excitation with an echo-planar imaging readout was implemented on a clinical CMR system. Dynamic myocardial stress perfusion images were acquired in six healthy pigs after bolus injection of hyperpolarized (13)C urea with the velocity-selective vs...
June 21, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28632653/imaging-adults-with-congenital-heart-disease-part-ii-advanced-cmr-techniques
#6
Anurag Sahu, Timothy C Slesnick
Because of great strides in medical care, survival into adulthood has become a common expectation in patients suffering from nearly all forms of congenital heart disease. As this aging population expands, the utilization of cardiac magnetic resonance imaging in their care continues to grow. Magnetic resonance technology has developed exponentially over the last 2 decades, and several advanced techniques for imaging adults with congenital heart disease have moved from the purely research arena into routine clinical care...
July 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28616562/coronary-calcification-compromises-myocardial-perfusion-irrespective-of-luminal-stenosis
#7
Michael Y Henein, Tarek Bengrid, Rachel Nicoll, Ying Zhao, Bengt Johansson, Axel Schmermund
AIM: The aim of this study was to evaluate the relationship between coronary artery calcification (CAC) assessed by multi-detector computed tomography (MDCT) and myocardial perfusion assessed by cardiac magnetic resonance imaging (CMR) in a group of symptomatic patients. METHOD: Retrospective analysis of 120 patients (age 65.1 ± 8.9 years, 88 males) who presented with atypical chest pain to Bethanien Hospital, Frankfurt, Germany, between 2007 and 2010 and who underwent CAC scoring using MDCT, CMR, and conventional coronary angiography...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28580766/pharmacological-stress-rest-perfusion-and-delayed-enhancement-cardiac-magnetic-resonance-identifies-a-very-early-cardiac-involvement-in-systemic-sclerosis-patients-of-recent-onset
#8
Roberto Giacomelli, Ernesto Di Cesare, Paola Cipriani, Piero Ruscitti, Alessandra Di Sibio, Vasiliki Liakouli, Antonio Gennarelli, Francesco Carubbi, Alessandra Splendiani, Onorina Berardicurti, Paola Di Benedetto, Francesco Ciccia, Giuliana Guggino, Ganna Radchenko, Giovanni Triolo, Carlo Masciocchi
OBJECTIVE: To evaluate occult cardiac involvement in asymptomatic systemic sclerosis (SSc) patients by pharmacological stress, rest perfusion and delayed enhancement cardiac magnetic resonance (CMR), for a very early identification of patients at higher risk of cardiac-related mortality. METHODS: Sixteen consecutive patients with definite SSc, fulfilling the American College of Rheumatology/European League Against Rheumatism 2013 classification criteria in less than 1 year from the onset of Raynaud's phenomenon, underwent pharmacological stress, rest perfusion and delayed enhancement CMR...
June 4, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28577544/deactivation-vs-asynchronous-pacing-prospective-evaluation-of-a-protocol-for-rhythm-management-in-patients-with-magnetic-resonance-conditional-pacemakers-undergoing-adenosine-stress-cardiovascular-magnetic-resonance-imaging
#9
Oliver Klein-Wiele, Marietta Garmer, Gianluca Barbone, Rhyan Urbien, Martin Busch, Kaffer Kara, Harald Schäfer, Michael Schulte-Hermes, Birgit Hailer, Dietrich Grönemeyer
BACKGROUND: Cardiovascular Magnetic Resonance (CMR) imaging with adenosine stress is an important diagnostic tool in patients with known or suspected coronary artery disease (CAD). However, the method is not yet established for CAD patients with pacemakers (PM) in clinical practice. A possible reason is that no recommendations exist for PM setting (paused pacing or asynchronous mode) during adenosine stress. We elaborated a protocol for rhythm management in clinical routine for PM patients that considers heart rate changes under adenosine using a test infusion of adenosine in selected patients...
June 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28547666/effects-of-caffeine-intake-prior-to-stress-cardiac-magnetic-resonance-perfusion-imaging-on-regadenoson-versus-adenosine-induced-hyperemia-as-measured-by-t1-mapping
#10
R van Dijk, D Kuijpers, T A M Kaandorp, P R M van Dijkman, R Vliegenthart, P van der Harst, M Oudkerk
The antagonistic effects of caffeine on adenosine receptors are a possible cause of false-negative stress perfusion imaging. The purpose of this study was to determine the effects of coffee intake <4 h prior to stress perfusion cardiac magnetic resonance imaging (CMR) in regadenoson- versus adenosine-induced hyperemia as measured with T1-mapping. 98 consecutive patients with suspected coronary artery disease referred for either adenosine or regadenoson perfusion CMR were included in this analysis. Twenty-four patients reported coffee consumption <4 h before CMR (15 patients with adenosine, and 9 patients with regadenoson); 74 patients reported no coffee intake (50 patients with adenosine, and 24 patients with regadenoson)...
May 25, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28540212/infarct-characterization-using-ct
#11
REVIEW
Ludovico La Grutta, Patrizia Toia, Erica Maffei, Filippo Cademartiri, Roberto Lagalla, Massimo Midiri
Myocardial infarction (MI) is a major cause of death and disability worldwide. The incidence is not expected to diminish, despite better prevention, diagnosis and treatment, because of the ageing population in industrialized countries and unhealthy lifestyles in developing countries. Nowadays it is highly requested an imaging tool able to evaluate MI and viability. Technology improvements determined an expansion of clinical indications from coronary plaque evaluation to functional applications (perfusion, ischemia and viability after MI) integrating additional phases and information in the mainstream examination...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28532781/usefulness-of-left-atrial-emptying-fraction-to-predict-ventricular-arrhythmias-in-patients-with-implantable-cardioverter-defibrillators
#12
Mischa T Rijnierse, Mehran Kamali Sadeghian, Sophie Schuurmans Stekhoven, P Stefan Biesbroek, Anne-Lotte C van der Lingen, Peter M van de Ven, Albert C van Rossum, Robin Nijveldt, Cornelis P Allaart
Impaired left atrial emptying fraction (LAEF) is an important predictor of mortality in patients with heart failure. As it may reflect increased LV wall stress, it might predict ventricular arrhythmia (VA) specifically. This study evaluated the predictive value of LAEF assessed with cardiovascular magnetic resonance (CMR) imaging with respect to appropriate device therapy (ADT) for VA and compared its role with CMR assessed scar size and other risk factors. In total, 229 patients (68% male, 63 ± 10 years, 61% ischemic cardiomyopathy) with LV ejection fraction ≤35% who underwent CMR and implantable cardioverter defibrillator (ICD) implantation for primary prevention in 2005 to 2012 were included...
July 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28528431/rapid-rest-stress-regadenoson-ungated-perfusion-cmr-for-detection-of-coronary-artery-disease-in-patients-with-atrial-fibrillation
#13
Erik T Bieging, I Haider, G Adluru, L Chang, P Suksaranjit, D Likhite, A Shaaban, L Jensen, B D Wilson, C J McGann, E DiBella
Cardiovascular magnetic resonance (CMR) perfusion has been established as a useful imaging modality for the detection of coronary artery disease (CAD). However, there are several limitations when applying standard, ECG-gated stress/rest perfusion CMR to patients with atrial fibrillation (AF). In this study we investigate an approach with no ECG gating and a rapid rest/stress perfusion protocol to determine its accuracy for detection of CAD in patients with AF. 26 patients with AF underwent a rapid rest/regadenoson stress CMR perfusion imaging protocol, and all patients had X-ray coronary angiography...
May 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28522658/effect-of-fontan-geometry-on-exercise-haemodynamics-and-its-potential-implications
#14
Elaine Tang, Zhenglun Alan Wei, Kevin K Whitehead, Reza H Khiabani, Maria Restrepo, Lucia Mirabella, James Bethel, Stephen M Paridon, Bradley S Marino, Mark A Fogel, Ajit P Yoganathan
OBJECTIVE: Exercise intolerance afflicts Fontan patients with total cavopulmonary connections (TCPCs) causing a reduction in quality of life. Optimising TCPC design is hypothesised to have a beneficial effect on exercise capacity. This study investigates relationships between TCPC geometries and exercise haemodynamics and performance. METHODS: This study included 47 patients who completed metabolic exercise stress test with cardiac magnetic resonance (CMR). Phase-contrast CMR images were acquired immediately following supine lower limb exercise...
May 18, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28482027/cmr-is-a-redox-responsive-regulator-of-dosr-that-contributes-to-m-tuberculosis-virulence
#15
Laura J Smith, Aleksandra Bochkareva, Matthew D Rolfe, Debbie M Hunt, Christina Kahramanoglou, Yvonne Braun, Angela Rodgers, Alix Blockley, Stephen Coade, Kathryn E A Lougheed, Nor Azian Hafneh, Sarah M Glenn, Jason C Crack, Nick E Le Brun, José W Saldanha, Vadim Makarov, Irene Nobeli, Kristine Arnvig, Galina V Mukamolova, Roger S Buxton, Jeffrey Green
Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state before progressing to life-threatening active infections. Transcriptional reprogramming is essential for TB pathogenesis. In vitro, Cmr (a member of the CRP/FNR super-family of transcription regulators) bound at a single DNA site to act as a dual regulator of cmr transcription and an activator of the divergent rv1676 gene. Transcriptional profiling and DNA-binding assays suggested that Cmr directly represses dosR expression...
May 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28473099/can-stress-cmr-impact-care-in-the-era%C3%A2-after-courage-and-fame-2
#16
EDITORIAL
Raymond Y Kwong, Leslee J Shaw, Eike Nagel
No abstract text is available yet for this article.
May 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28458600/diagnostic-performance-of-coronary-ct-angiography-stress-dual-energy-ct-perfusion-and-stress-perfusion-single-photon-emission-computed-tomography-for-coronary-artery-disease-comparison-with-combined-invasive-coronary-angiography-and-stress-perfusion-cardiac
#17
Hyun Woo Chung, Sung Min Ko, Hweung Kon Hwang, Young So, Jeong Geun Yi, Eun Jeong Lee
OBJECTIVE: To investigate the diagnostic performance of coronary computed tomography angiography (CCTA), stress dual-energy computed tomography perfusion (DE-CTP), stress perfusion single-photon emission computed tomography (SPECT), and the combinations of CCTA with myocardial perfusion imaging (CCTA + DE-CTP and CCTA + SPECT) for identifying coronary artery stenosis that causes myocardial hypoperfusion. Combined invasive coronary angiography (ICA) and stress perfusion cardiac magnetic resonance (SP-CMR) imaging are used as the reference standard...
May 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28455632/utility-of-stress-perfusion-cardiac-magnetic-resonance-in-follow-up-of-patients-undergoing-percutaneous-coronary-interventions-of-the-left-main-coronary-artery
#18
Samuele Nanni, Luigi Lovato, Gabriele Ghetti, Fabio Vagnarelli, GianGaspare Mineo, Rossella Fattori, Francesco Saia, Antonio Marzocchi, Cinzia Marrozzini, Maurizio Zompatori, Letizia Bacchi Reggiani, Franco Semprini, Giovanni Melandri, Elena Biagini, Anna Corsini, Giulia Norscini, Claudio Rapezzi
To assess the accuracy of cardiac magnetic resonance (CMR) for the diagnosis of angiographic stenosis after percutaneous coronary intervention (PCI) of left main coronary artery (LMCA). Patients undergone in the last year PCI of unprotected LMCA and scheduled for conventional X-ray coronary angiography (CXA) were evaluated with stress perfusion CMR within 2 weeks before CXA. Main contraindications to CMR were exclusion criteria. Stress perfusion CMR was performed to follow a bolus of contrast Gadobutrol after 3 min of adenosine infusion...
April 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28438306/relation-of-quantity-of-subepicardial-adipose-tissue-to-infarct-size-in-patients-with-st-elevation-myocardial-infarction
#19
Loïc Bière, Vianney Behaghel, Victor Mateus, Antonildes Assunção, Christoph Gräni, Kais Ouerghi, Sylvain Grall, Serge Willoteaux, Fabrice Prunier, Raymond Kwong, Alain Furber
According to the so-called obesity paradox, obesity might present a protective role in patients with myocardial infarction. We aimed to assess the influence of the epicardial adipose tissue (EAT) volume on cardiac healing and remodeling in patients with acute ST-elevation myocardial infarction. We prospectively included 193 consecutive patients presenting a first STEMI without known coronary artery disease. Cardiac magnetic resonance imaging was performed at baseline and after a 3-month follow-up. EAT volume was computed, and the population was divided into quartiles: the highest quartile of EAT defining the high EAT group (h-EAT)...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28412420/stress-perfusion-cmr-in-patients-with-known-and-suspected-cad-prognostic-value-and-optimal-ischemic-threshold-for-revascularization
#20
Gabriella Vincenti, Pier Giorgio Masci, Pierre Monney, Tobias Rutz, Sarah Hugelshofer, Mirdita Gaxherri, Olivier Muller, Juan F Iglesias, Eric Eeckhout, Valentina Lorenzoni, Cyril Pellaton, Christophe Sierro, Juerg Schwitter
OBJECTIVES: This study sought to determine the ischemia threshold and additional prognostic factors that identify patients for safe deferral from revascularizations in a large cohort of all-comer patients with known or suspected coronary artery disease (CAD). BACKGROUND: Stress-perfusion cardiac magnetic resonance (CMR) is increasingly used in daily practice for ischemia detection. However, there is insufficient evidence about the ischemia burden that identifies patients who benefit from revascularization versus those with a good prognosis who receive drugs only...
May 2017: JACC. Cardiovascular Imaging
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