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https://www.readbyqxmd.com/read/27926828/harnessing-cancer-cell-metabolism-for-theranostic-applications-using-metabolic-glycoengineering-of-sialic-acid-in-breast-cancer-as-a-pioneering-example
#1
REVIEW
Haitham A Badr, Dina M M AlSadek, Motawa E El-Houseini, Christopher T Saeui, Mohit P Mathew, Kevin J Yarema, Hafiz Ahmed
Abnormal cell surface display of sialic acids - a family of unusual 9-carbon sugars - is widely recognized as distinguishing feature of many types of cancer. Sialoglycans, however, typically cannot be identified with sufficiently high reproducibility and sensitivity to serve as clinically accepted biomarkers and similarly, almost all efforts to exploit cancer-specific differences in sialylation signatures for therapy remain in early stage development. In this report we provide an overview of important facets of glycosylation that contribute to cancer in general with a focus on breast cancer as an example of malignant disease characterized by aberrant sialylation...
November 25, 2016: Biomaterials
https://www.readbyqxmd.com/read/27926378/automated-segmentation-of-white-matter-fiber-bundles-using-diffusion-tensor-imaging-data-and-a-new-density-based-clustering-algorithm
#2
Tahereh Kamali, Daniel Stashuk
OBJECTIVE: Robust and accurate segmentation of brain white matter (WM) fiber bundles assists in diagnosing and assessing progression or remission of neuropsychiatric diseases such as schizophrenia, autism and depression. Supervised segmentation methods are infeasible in most applications since generating gold standards is too costly. Hence, there is a growing interest in designing unsupervised methods. However, most conventional unsupervised methods require the number of clusters be known in advance which is not possible in most applications...
October 2016: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/27925679/value-of-shear-wave-elastography-versus-contrast-enhanced-sonography-for-differentiating-benign-and-malignant-superficial-lymphadenopathy-unexplained-by-conventional-sonography
#3
Shi Tan, Li-Ying Miao, Li-Gang Cui, Peng-Fei Sun, Lin-Xue Qian
OBJECTIVES: This study aimed to compare the efficacy of shear wave elastography (SWE) and contrast-enhanced sonography in the differential diagnosis of superficial lymphadenopathy with abnormal imaging findings, which could not be otherwise confirmed by conventional sonography. METHODS: Forty-two enlarged superficial lymph nodes in 42 patients who met the screening criteria for this study were evaluated by both contrast-enhanced sonography and SWE. All lymph nodes underwent both methods using biopsy pathologic findings as a reference standard...
November 30, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27925483/application-of-gray-level-mapping-in-computed-tomographic-colonography-a-pilot-study-to-compare-with-traditional-surface-rendering-method-for-identification-and-differentiation-of-endoluminal-lesions
#4
Lih-Shyang Chen, Ta-Wen Hsu, Shao-Jer Chen, Shu-Han Chang, Chih-Wen Lin, Yu-Ruei Chen, Chin-Chiang Hsieh, Shu-Chen Han, Ku-Yaw Chang, Chun-Ju Hou
OBJECTIVES: In traditional surface rendering (SR) Computed tomographic endoscopy, only shape of endoluminal lesion is depicted without gray level information unless the volume rendering technique is used. However volume rendering technique is relatively slow and complex in terms of computation time and parameter setting. We use computed tomographic colonography (CTC) images as examples and report a new visualization technique by three dimensional (3D) gray level mapping (GM) to better identify and differentiate endoluminal lesions...
December 7, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27925466/a-prospective-evaluation-of-contrast-and-radiation-dose-and-image-quality-in-cardiac-ct-in-children-with-complex-congenital-heart-disease-using-low-concentration-iodinated-contrast-agent-and-low-tube-voltage-and-current
#5
Qiao-Ru Hou, Wei Gao, Yu Min Zhong, Ai Min Sun, Qian Wang, Hai Sheng Qiu, Fang Wang, Jian Ying Li, Liwei Hu
OBJECTIVE: To assess image quality, contrast dose and radiation dose in cardiac CT in children with congenital heart disease using low-concentration iodinated contrast agent and low tube voltage and current in comparison with standard-dose protocol. METHODS: 110 patients with congenital heart disease were randomized to one of the two scan protocols: Group A (n=45) with 120mA tube current and contrast agent of 270mgI/ml in concentration (Visipaque, GE Healthcare), and Group B (n=65) with the conventional 160mA and 370mgI/mL concentration contrast (Iopamiro, Bracco)...
December 7, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27925251/a-novel-method-for-blood-typing-using-nitrocellulose
#6
Parastoo Afshari, Nabiollah Abolfathi
Blood wicking in its steady state form -i.e. the uniform distribution of blood cells in plasma- is completely different from its coagulated form on a porous surface like paper. The hydrophilic property of the Cellulose leads to a Significant wicking of the blood cells on paper fibers after being rinsed by the isotonic solution. The difference in the wicking length of the blood cells in a steady state and the coagulated form could be considered as a criterion to recognize the blood type in paper-based kit. However, due to the molecular structure of the nitrocellulose, a better process occurs while separating the coagulated blood from the steady form of cells...
December 7, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27925066/dioctophyme-renale-nematoda-enoplida-in-domestic-dogs-and-cats-in-the-extreme-south-of-brazil
#7
Josaine Cristina da Silva Rappeti, Carolina Siqueira Mascarenhas, Soliane Carra Perera, Gertrud Müller, Fabiane Borelli Grecco, Luísa Mariano Cerqueira da Silva, Carolina da Fonseca Sapin, Stella Falkenberg Rausch, Marlete Brum Cleff
Dioctophyme renale is a zoonotic nematode that parasites the kidneys of wild and domestic carnivores, and it has been reported frequently in Brazil. The aim here was to register the number of cases of dogs and cats diagnosed with dioctophymosis by necropsy (1981 to 2014) and ultrasound examination (2010 to 2015) in Pelotas-RS. In this context, a survey was conducted on dioctophymosis cases diagnosed at the Veterinary Pathology Laboratory (LPV) and Veterinary Clinical Hospital (HCV) of the Federal University of Pelotas (UFPel), and at a specialist veterinary imaging diagnostics clinic...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27925038/image-guided-pancreatic-biopsy-can-we-trust-it-as-a-diagnostic-alternative
#8
Thiago Queroz, Wanderley Marques Bernardo, Marcos Roberto de Menezes
No abstract text is available yet for this article.
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27924406/estimating-legal-age-based-on-fusion-of-the-proximal-humeral-epiphysis
#9
María Benito Sánchez, Sónia Codinha, Alexandra Muñoz García, José Antonio Sánchez Sánchez
The increasing demand which requires ascertaining the legal age of undocumented individuals who reach the various countries of the European Community means that new lines of research must be developed which help respond to questions posed by the Justice Administration. For this reason, this study has been designed on the basis of fusion times of the proximal humeral epiphysis. Moreover, the ultrasound scan has been used as the diagnostic method. It is a non-invasive technique, unlike the radiograph, which is used under current standards for the forensic diagnosis of age...
December 6, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27924180/magnetic-resonance-spectroscopy-and-single-photon-emission-computed-tomography-in-the-evaluation-of-cerebral-tumors-a-case-report
#10
Ioannis Siasios, Varvara Valotassiou, Eftychia Kapsalaki, Ioannis Tsougos, Panagiotis Georgoulias, Aggeliki Fotiadou, Maria Ioannou, Georgios Koukoulis, Vassilios Dimopoulos, Kostas Fountas
In their daily clinical practice, physicians have to confront diagnostic dilemmas which cannot be resolved by the application of only one imaging technique. In this case report, we present a 66-year-old woman who was admitted to our institution for the surgical resection of a recently diagnosed brain tumor. The patient had a history of epileptic seizures and was hospitalized in the past for anti-phospholipid syndrome related to a non-Hodgkin lymphoma in remission. Magnetic resonance imaging (MRI) examination revealed an enhancing right parasagittal lesion with significant edema suggestive of a high grade glioma...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27923757/the-potentially-fatal-ogilvie-s-syndrome-in-lateral-transpsoas-access-surgery-a-multi-institutional-experience-with-2930-patients
#11
Jacob Januszewski, Sean K Keem, William Smith, Joshua M Beckman, Adam S Kanter, Rod J Oskuian, William Taylor, Juan S Uribe
BACKGROUND: Ogilvie's syndrome (OS) is a relatively uncommon pathology characterized by significant colonic dilation in the absence of mechanical obstruction. If unrecognized and untreated, cecal perforation resulting in mortality rate of 25-71% may occur. It is a potentially underdiagnosed condition in the lateral transpsoas appraoch population due to its uncommon nature and imitation of other well-known pathologies. METHODS: A total of 2930 patients from 6 separate institutions were retrospectively reviewed since 2007 and screened for OS...
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27923715/imaging-phenotyping-using-radiomics-to-predict-micropapillary-pattern-within-lung-adenocarcinoma
#12
So Hee Song, Hyunjin Park, Geewon Lee, Ho Yun Lee, Insuk Sohn, Hye Seung Kim, Seung Hak Lee, Ji Yun Jeong, Jhingook Kim, Kyung Soo Lee, Young Mog Shim
INTRODUCTION: Lung adenocarcinoma (ADC) with micropapillary pattern have been reported to have a poor prognosis. However, few studies have reported on the imaging-based identification of micropapillary component, which were all subjective studies dealing with qualitative CT variables. We aimed to explore imaging phenotyping using a radiomics approach for predicting micropapillary pattern within lung ADC METHODS: We enrolled 339 patients who underwent complete resection for lung ADC. Histologic subtypes and grades of the ADCs were classified...
December 3, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27923382/ectopic-third-molars-in-the-sigmoid-notch-etiology-diagnostic-imaging-and-treatment-options
#13
Marcel Hanisch, Leopold F Fröhlich, Johannes Kleinheinz
BACKGROUND: The etiology of ectopic third molars located in the sigmoid notch of the mandible is unclear. Only a few cases have been reported. The aim of this article is to discuss the etiology as well as treatment options and diagnostic imaging techniques. METHODS: A PubMed and Medline search of the literature from 1965 to 2015 to ectopic third molars in the mandibular notch was performed. Furthermore, a clinical case provided by the authors is reported. RESULTS: Among the eight reviewed cases, two male and six female patients were affected that ranged from 25 to 62 years of age (mean 48...
December 6, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27923374/a-case-of-infected-schwannoma-mimicking-malignant-tumor
#14
Mamer S Rosario, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Hiroyuki Inatani, Takashi Higuchi, Hiroyuki Tsuchiya
BACKGROUND: Infected schwannoma has been reported, this being one of the four cases published in the literature. Infected schwannoma has proven to be a tough diagnostic challenge to the treating tumor surgeon, mimicking infectious entities and most essentially, a malignant tumor. CASE PRESENTATION: The authors report the case of a 64-year-old male with a soft tissue mass in his right gluteal area that presented initially with right leg pain, then later with signs of inflammation on the tumor area...
December 7, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27923351/intra-and-inter-observer-reliability-of-a-new-standardized-diagnostic-method-using-spect-ct-in-patients-with-osteochondral-lesions-of-the-ankle-joint
#15
Geneviève Hassink, Enrique A Testa, André Leumann, Thomas Hügle, Helmut Rasch, Michael T Hirschmann
BACKGROUND: Single Photon Emission Computed Tomography-Computed Tomography (SPECT/CT) gains an important part of diagnostics in patients with osteochondral lesions (OCL). SPECT/CT is a hybrid imaging modality, which combines a 3D scintigraphy (SPECT) and computerized tomography (CT) into one single procedure and combines metabolic data, structural and mechanical information. The purpose of the study was to develop and evaluate a standardized method to anatomically localize and quantitatively analyze the bone SPECT tracer activity of the ankle joint using SPECT/CT...
December 7, 2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27923231/congenital-absence-of-the-pericardium-a-systematic-approach-to-diagnosis-and-management
#16
Bo Xu, Jorge Betancor, Craig Asher, Adriana Rosario, Allan Klein
Congenital absence of the pericardium (CAP) is a rare condition. Failure to recognize the clinical features of this condition can lead to incorrect and delayed diagnosis. Limited data are available regarding the optimal approach to diagnose and manage patients with suspected CAP. Due to the rare nature of CAP, this condition can present diagnostic and management dilemmas for clinicians. Using 3 cases of CAP as a framework, a clinically focused review on the diagnosis and management of CAP is presented. Clinicians will be provided with a systematic approach to evaluating patients with suspected CAP, incorporating key history, examination, and multimodality cardiovascular imaging investigations...
December 7, 2016: Cardiology
https://www.readbyqxmd.com/read/27922877/diagnostic-accuracy-of-central-venous-catheter-confirmation-by-bedside-ultrasound-versus-chest-radiography-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#17
Enyo A Ablordeppey, Anne M Drewry, Alexander B Beyer, Daniel L Theodoro, Susan A Fowler, Brian M Fuller, Christopher R Carpenter
OBJECTIVE: We performed a systematic review and meta-analysis to examine the accuracy of bedside ultrasound for confirmation of central venous catheter position and exclusion of pneumothorax compared with chest radiography. DATA SOURCES: PubMed, Embase, Cochrane Central Register of Controlled Trials, reference lists, conference proceedings and ClinicalTrials.gov. STUDY SELECTION: Articles and abstracts describing the diagnostic accuracy of bedside ultrasound compared with chest radiography for confirmation of central venous catheters in sufficient detail to reconstruct 2 × 2 contingency tables were reviewed...
December 5, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27922871/excellent-response-to-177lu-psma-617-radioligand-therapy-in-a-patient-with-advanced-metastatic-castration-resistant-prostate-cancer-evaluated-by-68ga-psma-pet-ct
#18
Wolfgang Roll, Axel Bode, Matthias Weckesser, Martin Bögemann, Kambiz Rahbar
Recently radiolabeled ligands targeting prostate specific membrane antigen (PSMA) have been introduced for diagnostics and treatment of prostate cancer. Labeled with Lutetium, PSMA radioligand therapy (RLT) is one of the most promising new treatments of metastatic castration refractory prostate cancer. We present images of Ga-PSMA PET/CT and parameters of response of a 75-year-old heavily pretreated metastatic castration refractory prostate cancer patient with extended bone metastases, showing an extraordinary biochemical response in PSA-levels concordant to SUV decline in bone metastases...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27922865/additional-value-of-early-phase-18f-fp-cit-pet-image-for-differential-diagnosis-of-atypical-parkinsonism
#19
Soyoung Jin, Minyoung Oh, Seung Jun Oh, Jungsu S Oh, Sang Ju Lee, Sun Ju Chung, Jae Seung Kim
PURPOSE: Regional cerebral perfusion is coupled to metabolism in general. Early perfusion dominant imaging using F-FP-CIT PET (pCIT) may provide complementary information to delayed dopamine transporter dominant images. We investigated the ability of pCIT to differentiate atypical Parkinson disorder from Parkinson disease (PD) compared to FDG and the image quality for optimizing the acquisition time. METHODS: Sixty-seven subjects [PD, 23 subjects; multiple system atrophy-cerebellar type (MSA-C), 27 subjects; MSA-Parkinson type (MSA-P), 12 subjects; and progressive supranuclear palsy (PSP), 5 subjects] underwent F-FP-CIT and FDG PET...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27922502/the-limb-girdle-muscular-dystrophies-and-the-dystrophinopathies
#20
Stanley Jones P Iyadurai, John T Kissel
PURPOSE OF REVIEW: The classic approach to identifying and accurately diagnosing limb-girdle muscular dystrophies (LGMDs) relied heavily on phenotypic characterization and ancillary studies including muscle biopsy. Because of rapid advances in genetic sequencing methodologies, several additional LGMDs have been molecularly characterized, and the diagnostic approach to these disorders has been simplified. This article summarizes the epidemiology, clinical features, and genetic defects underlying the LGMDs...
December 2016: Continuum: Lifelong Learning in Neurology
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