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Lipid emulsion

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https://www.readbyqxmd.com/read/29456604/death-from-kratom-toxicity-and-the-possible-role-of-intralipid
#1
Geeta Aggarwal, Edward Robertson, James McKinlay, Edward Walter
We present the case of a 26-year-old man who was brought into our emergency department in cardiorespiratory arrest, having taken Kratom 24 h previously. Despite multi-organ support, he deteriorated and died from cardiorespiratory failure and hypoxic brain damage 12 h later. Lipid emulsion was given, with significant temporary improvement in the cardiorespiratory failure. Kratom is derived from Mitragyna speciosa, a tropical deciduous and evergreen tree in the coffee family, and is native to Southeast Asia, and its leaves are used as a legal high in some parts of the world...
February 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29456602/review-of-management-in-cardiotoxic-overdose-and-efficacy-of-delayed-intralipid-use
#2
Edward Walter, James McKinlay, Jade Corbett, Justin Kirk-Bayley
We present the case of a 51-year-old woman admitted to our intensive care unit following an intentional overdose of a calcium channel antagonist and a beta blocker. The resultant hypotension was reversed with glucagon, noradrenaline, calcium and high-dose insulin. Despite these interventions, she remained vasoplegic and received a delayed, standard dose of intralipid. Subsequently, the vasoplegia resolved rapidly, and the vasopressor was stopped. Here, we review the management of overdose of calcium channel and beta-adrenergic receptor blockers, concentrating on the pharmacology of lipid emulsion therapy...
February 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29445923/inpatient-outcomes-of-preterm-infants-receiving-%C3%AF-3-enriched-lipid-emulsion-smoflipid-an-observational-study
#3
Nalin Choudhary, Kenneth Tan, Atul Malhotra
Neonatal units have started to switch from using conventional soy-based to alternate lipid emulsions, like SMOFlipid. SMOFlipid has been associated with an improvement in biochemical parameters and delays progression of parenteral nutrition-associated liver disease (PNALD). This retrospective epoch study aimed to compare clinically relevant neonatal outcomes in preterm infants (< 32 weeks), receiving SMOFlipid versus Intralipid. We compared clinical outcomes in two epochs-epoch 1 (Intralipid, October 2013-June 2015) versus epoch 2 (SMOFlipid, July 2015-March 2017)...
February 14, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29441958/preparation-and-in-vivo-evaluation-of-cytochrome-c-containing-liposomes
#4
O G Katsai, O A Ruban, Y M Krasnopolskyi
This study investigates the development of a method for obtaining cytochrome C-containing liposomes (LS-Cyt), and evaluates their stability and specific activity. LS-Cyt were intended for the therapy of ophthalmic diseases. LS-Cyt were prepared by high pressure homogenization technique and lyophilized to obtain freeze-dried LS-Cyt. It was proposed to use anionic phospholipid- dipalmitoylphosphatidylglycerol (DPPG-Na) and phosphatidylcholine (PC) in a nanoparticulate composition. Were investigated various concentrations of lactose and trehalose as cryoprotectants...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441672/role-of-solid-lipid-nanoparticles-as-photoprotective-agents-in-cosmetics
#5
REVIEW
Jobin Jose, Gladyston Netto
BACKGROUND: Novel drug delivery systems have gained popularity since last two decades because of its advantages over conventional dosage forms. Effect of UV radiation on skin can cause either acute or chronic damage to our skin. Solid lipid nanoparticles (SLNs) were developed as novel carrier over the conventional carrier systems like liposomes and emulsions. The SLNs were selected as a carrier for the formulation because of its ability to protect the labile drug particles, the ability to make the drug release in a controlled manner, and occlusive property of the SLNs...
February 13, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29436744/long-term-use-of-mixed-oil-lipid-emulsion-in-adult-home-parenteral-nutrition-patients-a-case-series
#6
Manpreet S Mundi, Megan T McMahon, Jennifer J Carnell, Ryan T Hurt
BACKGROUND: Despite providing significant benefits, home parenteral nutrition (HPN) can be associated with complications such as infections, intestinal failure-associated liver disease, and metabolic abnormalities. Soybean oil (SO)-based intravenous lipid emulsion (ILE) has been noted to contribute to some of these complications, leading to the development of alternative sources of ILE. Mixed-oil (MO) ILE has recently been approved for use in adults with short-term studies revealing a benefit over SO ILE...
February 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29433288/impact-of-oil-droplet-concentration-on-the-optical-rheological-and-stability-characteristics-of-o-w-emulsions-stabilized-with-plant-based-surfactant-potential-application-as-non-dairy-creamers
#7
Cheryl Chung, Alexander Sher, Philippe Rousset, David Julian McClements
The development of plant-based foods and beverages is becoming increasingly popular because of growing consumer concerns about perceived ethical, health, and environmental issues. The current study examined the influence of oil droplet concentration on the physicochemical properties of oil-in-water (O/W) emulsions stabilized with a plant-based surfactant. Emulsions were utilized as model creamers, which consisted of medium chain triglycerides (MCT) as the oil phase and quillaja saponin as a plant-based surfactant...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433284/stability-of-the-potent-antioxidant-peptide-snaac-identified-from-spanish-dry-cured-ham
#8
Marta Gallego, Leticia Mora, Milagro Reig, Fidel Toldrá
Antioxidant peptides positively regulate oxidative stress in the human body as well as delay, retard or prevent protein and lipid oxidation in food products. Spanish dry-cured ham has been reported as a good source of bioactive peptides, being SNAAC the most active antioxidant peptide identified to date. In this work, the stability of this peptide against in vitro digestion, heat treatments and different salt concentrations was evaluated using three methods for measuring antioxidant activity: β-carotene bleaching assay, ABTS radical scavenging capacity and ORAC assay...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433249/emulsions-as-delivery-systems-for-gamma-and-delta-tocotrienols-formation-properties-and-simulated-gastrointestinal-fate
#9
Fei Xu, Janam K Pandya, Cheryl Chung, David Julian McClements, Amanda J Kinchla
Tocotrienols have been reported to have stronger bioactivities than tocopherols, and may therefore be suitable as a potent source of vitamin E in functional foods, supplements, and pharmaceuticals. However, their inclusion into new products is hindered by their low water-solubility and oral bioavailability. Oil-in-water emulsions (O/W) could provide an adequate delivery system for these bioactive compounds. Tocotrienols were tested in bulk oil and within O/W conventional emulsions (>10μm) and nanoemulsions (<350nm)...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433234/effect-of-xanthan-gum-on-lipid-digestion-and-bioaccessibility-of-%C3%AE-carotene-loaded-rice-starch-based-filled-hydrogels
#10
Shinjae Park, Saehun Mun, Yong-Ro Kim
The aim of this study was to examine the effects of xanthan gum on the lipid digestibility, rheological properties, and β-carotene bioaccessibility of rice starch-based filled hydrogels. β-Carotene was solubilized within lipid droplets of emulsion that were then entrapped within rice starch hydrogels fabricated with different concentrations of xanthan gum. At a low concentration of xanthan gum (<0.5wt%), the viscous characteristics of the filled starch hydrogels increased. Furthermore, these hydrogels had a slower rate of lipid digestion than the β-carotene-loaded emulsion...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433230/in-vitro-digestion-behavior-of-water-in-oil-in-water-emulsions-with-gelled-oil-water-inner-phases
#11
Jonathan Andrade, Amanda J Wright, Milena Corredig
Double emulsions may be able to protect and release in a controlled manner bioactive compounds during digestion of food matrices. It was hypothesized that the physical state and solid content in the inner phases of water-in-oil-in-water (W1/O/W2) emulsions may affect the overall stability and the release behavior of bioactives during in vitro digestion. Therefore, hydrophobic (phytosterols or Vitamin D3) and hydrophilic (Vitamin B12) molecules were incorporated in double emulsions prepared either with a liquid (soybean oil - SO) or oil-fat gel (soybean oil+trimyristin - STO) lipid phase and liquid internal aqueous phase...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433200/relationship-between-nano-micro-structure-and-physical-properties-of-tio2-sodium-caseinate-composite-films
#12
Juan Manuel Montes-de-Oca-Ávalos, Davide Altamura, Roberto Jorge Candal, Francesco Scattarella, Dritan Siliqi, Cinzia Giannini, María Lidia Herrera
Films obtained by casting, starting from conventional emulsions (CE), nanoemulsions (NE) or their gels, which led to different structures, with the aim of explore the relationship between structure and physical properties, were prepared. Sodium caseinate was used as the matrix, glycerol as plasticizer, glucono-delta-lactone as acidulant to form the gels, and TiO2 nanoparticles as reinforcement to improve physical behavior. Structural characterization was performed by SAXS and WAXS (Small and Wide Angle X-ray Scattering, respectively), combined with confocal and scanning electron microscopy...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29428793/confocal-raman-microspectroscopy-as-an-alternative-method-to-investigate-the-extraction-of-lipids-from-stratum-corneum-by-emulsifiers-and-formulations
#13
Ziwei Zhang, Dominique Jasmin Lunter
The purpose of this study was to investigate the impact of emulsifiers and formulations on intercellular lipids of porcine stratum corneum (SC) and evaluate confocal Raman microscopy (CRM) as an alternative method in this research context. To this end, four different formulations were used: three conventional creams that contained ionic and/or non-ionic emulsifiers and one surfactants-free emulsion stabilized by a polymeric emulsifier. Additionally, all emulsifiers were tested in aqueous solution/dispersion in the respective concentrations as present in the formulations...
February 8, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29424289/influences-of-the-vehicle-in-the-spreading-and-release-of-betamethasone
#14
Sonia Molesini, Federica Urto, Alexandra D Cvetkovska, Vincenzo Bettoli, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, Silvia Vertuani
AIM: We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles: a polymer and lipid-enriched cream and a conventional oil-in-water emulsion. METHODOLOGY: Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers. RESULTS: Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration...
February 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29415837/parenteral-nutrition-associated-cholestasis-and-triglyceridemia-in-surgical-term-and-near-term-neonates-a-pilot-randomized-controlled-trial-of-two-mixed-intravenous-lipid-emulsions
#15
Luís Pereira-da-Silva, Sara Nóbrega, Maria Luísa Rosa, Marta Alves, Ana Pita, Daniel Virella, Ana Luísa Papoila, Micaela Serelha, Gonçalo Cordeiro-Ferreira, Berthold Koletzko
BACKGROUND: Cholestasis is a common complication in infants receiving prolonged parenteral nutrition (PN). We studied the effects of two intravenous lipid emulsions composed with either 30% soybean oil, 30% medium-chain triglycerides (MCT), 25% olive oil, and 15% fish oil (SMOF) or with 50% MCT and 50% soybean oil n-6 (MCT/SOY) on the incidence of cholestasis in surgical term and near-term neonates. METHODS: A single-center, double-blinded, randomized controlled trial compared the incidence of cholestasis using either SMOF or MCT/SOY in neonates born at gestational age ≥34 weeks undergoing major surgery...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29415640/in-vivo-effects-of-intravenous-lipid-emulsion-on-lung-tissue-in-an-experimental-model-of-acute-malathion-intoxication
#16
Murat Uysal, Serhat Karaman
Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatment effect of ILE on rat lung tissue in a toxicokinetic model of malathion exposure. Twenty-one adult Wistar albino rats were randomly divided into three equal groups. The groups were organized as group I (control), group II (malathion), and group III (malathion + ILE treatment)...
February 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29412904/pulse-seed-germination-improves-antioxidative-activity-of-phenolic-compounds-in-stripped-soybean-oil-in-water-emulsions
#17
Minwei Xu, Zhao Jin, Allen Peckrul, Bingcan Chen
The purpose of this study was to investigate antioxidative activity of phenolic compounds extracted from germinated pulse seed including chickpeas, lentils and yellow peas. Phenolic compounds were extracted at different germination time and total phenolic content was examined by Folin Ciocalteu's reaction. Antioxidative activity of extracts was characterized by in vitro assay including 2, 2-diphenyl-1-picrylhydrazyl radical scavenging capacity (DPPH), oxygen radical absorbance capacity (ORAC), iron-binding assay, and in stripped soybean oil-in-water emulsions...
June 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29412674/combination-of-phospholipid-complex-and-submicron-emulsion-techniques-for-improving-oral-bioavailability-and-therapeutic-efficacy-of-water-insoluble-drug
#18
Linghao Qin, Yawei Niu, Yuemin Wang, Xiaomei Chen
Water-insoluble drugs can not be absorbed effectively through gastrointestinal tract due to insufficient solubility and often face the problems of low bioavailability and poor therapeutic efficacy. To overcome these biopharmaceutical challenges, lipid-based formulations were suggested and have been researched in recent years. In this study, we used atorvastatin as a model drug to prepare a phospholipid complex pro-drug system to upgrade its lipophilicity and further developed a drug loaded submicron emulsion to improve its in vivo bioavailability...
February 7, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29412454/antioxidant-properties-of-astaxanthin-in-oil-in-water-emulsions-with-differently-charged-emulsifiers-under-chlorophyll-photosensitization
#19
BoRa Yi, Mi-Ja Kim, JaeHwan Lee
The antioxidative or prooxidative properties of astaxanthin at the concentrations of 0, 10, and 100 μM were determined in oil-in-water (O/W) emulsions containing neutral, anionic, and cationic emulsifiers, which was Tween 20, sodium dodecyl sulfate, cetyltrimethylammonium bromide (CTAB), respectively, under chlorophyll photosensitization. The oxidative parameters and headspace volatiles were analyzed in O/W emulsions. In the 24 h period of visible light irradiation, 100 μM of astaxanthin acted as an antioxidant in O/W emulsions containing neutral and anionic emulsifiers...
February 7, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29407919/3d-confocal-raman-imaging-of-oil-rich-emulsion-from-enzyme-assisted-aqueous-extraction-of-extruded-soybean-powder
#20
Longkun Wu, Limin Wang, Baokun Qi, Xiaonan Zhang, Fusheng Chen, Yang Li, Xiaonan Sui, Lianzhou Jiang
The understanding of the structure morphology of oil-rich emulsion from enzyme-assisted extraction processing (EAEP) was a critical step to break the oil-rich emulsion structure in order to recover oil. Albeit EAEP method has been applied as an alternative way to conventional solvent extraction method, the structure morphology of oil-rich emulsion was still unclear. The current study aimed to investigate the structure morphology of oil-rich emulsion from EAEP using 3D confocal Raman imaging technique. With increasing the enzymatic hydrolysis duration from 1 to 3 h, the stability of oil-rich emulsion was decreased as visualized in the 3D confocal Raman images that the protein and oil were mixed together...
May 30, 2018: Food Chemistry
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