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Sijie Tan, Changqing Xu, Wanting Zhu, Jesse Willis, Christoph N Seubert, Nikolaus Gravenstein, Colin Sumners, Anatoly E Martynyuk
BACKGROUND: The authors studied whether neonatal propofol anesthesia affects development of the endocrine and neural systems. METHODS: Sprague-Dawley rats were anesthetized using intraperitoneal propofol for 5 h on postnatal days (P) 4, 5, or 6. Pups that received either saline or intralipid, but not those in the negative control groups, were also maternally separated for 5 h. Serum levels of corticosterone were measured immediately after anesthesia and in adulthood after prepulse inhibition of acoustic startle testing (≥P80), followed by measurement of hippocampal neuronal activity...
November 2014: Anesthesiology
Lei-Lei Ma, Hong-Wei Ge, Fei-Juan Kong, Ling-Bo Qian, Bang-Chuan Hu, Qian Li, Liang Xu, Jing-Quan Liu, Yun-Xiang Xu, Ren-Hua Sun
Recent studies have demonstrated that intralipid (ILP) conferred myocardial protection against ischemia-reperfusion (IR) injury through activation of reperfusion injury salvage kinase (RISK) pathway. As RISK signal has been shown to be impaired in hypertrophied myocardium, we investigated whether ILP-induced cardiac protection was maintained in hypertrophied rat hearts. Transverse aortic constriction was performed on male Sprague-Dawley rats to induce left ventricular hypertrophy, then sham-operated or hypertrophied rat hearts were isolated and perfused retrogradely by the Langendorff for 30 min (equilibration) followed by 40 min of ischemia and then 120 min of reperfusion...
May 2014: Shock
M de Queiroz Siqueira, D Chassard, H Musard, A Heilporn, J-C Cejka, O Leveneur, B Allaouchiche, O Rhondali
BACKGROUND: The optimal dosing regimens of lipid emulsion, epinephrine, or both are not yet determined in neonates in cases of local anaesthetic systemic toxicity (LAST). METHODS: Newborn piglets received levobupivacaine until cardiovascular collapse occurred. Standard cardiopulmonary resuscitation was started and electrocardiogram (ECG) was monitored for ventricular tachycardia, fibrillation, or QRS prolongation. Piglets were then randomly allocated to four groups: control (saline), Intralipid(®) alone, epinephrine alone, or a combination of Intralipd plus epinephrine...
April 2014: British Journal of Anaesthesia
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