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https://www.readbyqxmd.com/read/29791448/abundance-and-distribution-of-microplastics-within-surface-sediments-of-a-key-shellfish-growing-region-of-canada
#1
T N Kazmiruk, V D Kazmiruk, L I Bendell
The abundance and distribution of microplastics within 5 sediment size classes (>5000 μm, 1000-5000 μm, 250-1000 μm, 250-0.63 μm and < 0.63 μm) were determined for 16 sites within Lambert Channel and Baynes Sound, British Columbia, Canada. This region is Canada's premier growing area for the Pacific oyster (Crassostrea gigas). Microplastics were found at all sampling locations indicating widespread contamination of this region with these particles. Three types of microplastics were recovered: microbeads, which occurred in the greatest number (up to 25000/kg dry sediment) and microfibers and microfragments, which were much less in number compared with microbeads and occurred in similar amounts (100-300/kg dry sediment)...
2018: PloS One
https://www.readbyqxmd.com/read/29791348/detection-of-iron-atoms-by-emission-spectroscopy-and-laser-induced-fluorescence-in-solid-propellant-flames
#2
G Vilmart, N Dorval, M Orain, D Lambert, R Devillers, Y Fabignon, B Attal-Tretout, A Bresson
Planar laser-induced fluorescence on atomic iron is investigated in this paper, and a measurement strategy is proposed to monitor the fluorescence of iron atoms with good sensitivity. A model is proposed to fit the experimental fluorescence spectra, and good agreement is found between simulated and experimental spectra. Emission and laser-induced fluorescence measurements are performed in the flames of ammonium perchlorate composite propellants containing iron-based catalysts. A fluorescence signal from iron atoms after excitation at 248 nm is observed for the first time in propellant flames...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791087/sexual-and-somatic-development-of-wood-frog-tadpoles-along-a-thermal-gradient
#3
Max R Lambert, Meredith S Smylie, Amber J Roman, L Kealoha Freidenburg, David K Skelly
All amphibian species are known to have genetic sex determination. However, a variety of environmental conditions can moderate sexual differentiation, in some cases leading to sex reversal and skewed sex ratios. While there has been a recent focus on chemically-induced sex reversal in amphibians, temperature can also influence sexual differentiation. Building upon a classic 1929 study by Emil Witschi, we assessed temperature-mediated sex reversal. Witschi found that the wood frog sex ratio is 100% male at a high temperature (32°C) compared to a 50:50 sex ratio at 20°C...
May 23, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29785274/cross-sectional-assessment-of-achievement-of-therapeutic-goals-in-a-canadian-multidisciplinary-clinic-for-patients-with-advanced-chronic-kidney-disease
#4
Félix Rinfret, France Lambert, Joseph Tchetagni Youmbissi, Jean-François Arcand, Richard Turcot, Maral Alimardani Bessette, Solange Bourque, Vincent Moreau, Karine Tousignant, Diane Deschênes, Lyne Cloutier
Background: The implementation of advanced chronic kidney disease (CKD) multidisciplinary clinics has now demonstrated their effectiveness in delaying and even avoiding dialysis for patients with CKD. However, very little has been documented on the management and achievement of targets for a number of parameters in this context. Objective: Our goal was to assess our multidisciplinary clinic therapy performance in relation to the targets for hypertension, anemia, and calcium phosphate assessment...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29785180/career-choices-and-career-progression-of-junior-doctors-in-dermatology-surveys-of-uk-medical-graduates
#5
Atena Barat, Michael J Goldacre, Trevor W Lambert
Objective: To report UK-trained doctors' career choices for dermatology, career destinations, and factors influencing career pathways. Methods: Multicohort multipurpose longitudinal surveys of UK-trained doctors who graduated between 1974 and 2015. Results: In all, 40,412 doctors (58% of graduates) responded in year 1, 31,466 (64%) in year 3, and 24,970 (67%) in year 5. One year after graduation, 1.7% of women and 0.6% of men made dermatology their first choice but by five years after graduation the respective figures were 1...
2018: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29784239/paraneoplastic-syndromes-in-ophthalmology
#6
REVIEW
A Bussat, S Langner-Lemercier, A Salmon, F Mouriaux
Paraneoplastic syndromes involving the visual system are a heterogeneous group of disorders occurring in the setting of systemic malignancy. They are unrelated to local tumor invasion or metastasis and unexplained by nutritional, metabolic, infectious or iatrogenic causes. The presence of antibodies may aid in the diagnosis of a paraneoplastic syndrome, although this is not an absolute requirement. Chorioretinal involvement is seen in CAR (cancer-associated retinopathy) syndrome, MAR (melanoma-associated retinopathy) syndrome, paraneoplastic vitelliform maculopathy, and bilateral diffuse uveal melanocytic proliferation...
May 18, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29780968/the-influence-of-obesity-on-operating-room-time-and-perioperative-complications-in-cochlear-implantation
#7
Jonathan L Hatch, Isabel M Boersma, Forest W Weir, Michael J Bauschard, Meredith A Holcomb, Paul R Lambert, Ted A Meyer
Objective: The rising incidence of obesity in the United States is associated with increased healthcare expenditures and resource allocation. Obesity has been associated with prolonged operating times during surgical procedures. The primary objective of this study is to compare body mass index (BMI) to length of surgery during cochlear implantation. Methods: A retrospective case control study from a tertiary academic referral center was performed. Patients included were adults who underwent primary, single-sided cochlear implantation with documented BMI and operating room (OR) times from January 2009 to July 2015...
December 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29780795/a-novel-de-novo-mutation-in-the-cd40-ligand-gene-in-a-patient-with-a-mild-x-linked-hyper-igm-phenotype-initially-diagnosed-as-cvid-new-aspects-of-old-diseases
#8
Tábata T França, Luiz F B Leite, Tiago A Maximo, Christiane G Lambert, Nuria B Zurro, Wilma C N Forte, Antonio Condino-Neto
Mutations in the CD40 ligand (CD40L) gene ( CD40LG ) lead to X-linked hyper-IgM syndrome (X-HIGM), which is a primary immunodeficiency (PID) characterized by decreased serum levels of IgG and IgA and normal or elevated IgM levels. Although most X-HIGM patients become symptomatic during the first or second year of life, during which they exhibit recurrent infections, some patients exhibit mild phenotypes, which are usually associated with hypomorphic mutations that do not abrogate protein expression or function...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29776061/local-lubrication-model-for-spherical-particles-within-incompressible-navier-stokes-flows
#9
B Lambert, L Weynans, M Bergmann
The lubrication forces are short-range hydrodynamic interactions essential to describe suspension of the particles. Usually, they are underestimated in direct numerical simulations of particle-laden flows. In this paper, we propose a lubrication model for a coupled volume penalization method and discrete element method solver that estimates the unresolved hydrodynamic forces and torques in an incompressible Navier-Stokes flow. Corrections are made locally on the surface of the interacting particles without any assumption on the global particle shape...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29772682/the-association-of-dietary-fiber-intake-with-cardiometabolic-risk-in-four-countries-across-the-epidemiologic-transition
#10
Louise Lie, Laquita Brown, Terrence E Forrester, Jacob Plange-Rhule, Pascal Bovet, Estelle V Lambert, Brian T Layden, Amy Luke, Lara R Dugas
The greatest burden of cardiovascular disease is now carried by developing countries with cardiometabolic conditions such as metabolic syndrome, obesity and inflammation believed to be the driving force behind this epidemic. Dietary fiber is known to have protective effects against obesity, type 2 diabetes, cardiovascular disease and the metabolic syndrome. Considering the emerging prevalence of these cardiometabolic disease states across the epidemiologic transition, the objective of this study is to explore these associations of dietary fiber with cardiometabolic risk factors in four countries across the epidemiologic transition...
May 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29770433/behavioral-contrast-research-and-areas-for-investigation
#11
Megan A Boyle, Audrey N Hoffmann, Joseph M Lambert
Behavioral contrast occurs when a change in reinforcement rate in one context results in a change in behavior in the opposite direction in an unchanged context. Despite decades of study by basic researchers, behavioral contrast has remained largely an unstudied phenomenon among applied researchers. The purpose of this paper is to occasion translational and applied research on behavioral contrast with the aim of predicting and controlling socially significant behavior in unchanged contexts. We present a brief history of contrast and related definitions, review research with human and nonhuman subjects, and suggest future directions for applied and translational researchers...
May 16, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29769727/microbial-signals-drive-pre-leukaemic-myeloproliferation-in-a-tet2-deficient-host
#12
Marlies Meisel, Reinhard Hinterleitner, Alain Pacis, Li Chen, Zachary M Earley, Toufic Mayassi, Joseph F Pierre, Jordan D Ernest, Heather J Galipeau, Nikolaus Thuille, Romain Bouziat, Manuel Buscarlet, Daina L Ringus, Yitang Wang, Ye Li, Vu Dinh, Sangman M Kim, Benjamin D McDonald, Matthew A Zurenski, Mark W Musch, Glaucia C Furtado, Sergio A Lira, Gottfried Baier, Eugene B Chang, A Murat Eren, Christopher R Weber, Lambert Busque, Lucy A Godley, Elena F Verdú, Luis B Barreiro, Bana Jabri
Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1-7 . In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with a net developmental bias towards the myeloid lineage1,4,8,9 . However, pre-leukaemic myeloproliferation (PMP) occurs in only a fraction of Tet2-/- mice8,9 and humans with TET2 mutations1,3,5-7 , suggesting that extrinsic non-cell-autonomous factors are required for disease onset...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769666/an-unexpected-and-persistent-increase-in-global-emissions-of-ozone-depleting-cfc-11
#13
Stephen A Montzka, Geoff S Dutton, Pengfei Yu, Eric Ray, Robert W Portmann, John S Daniel, Lambert Kuijpers, Brad D Hall, Debra Mondeel, Carolina Siso, J David Nance, Matt Rigby, Alistair J Manning, Lei Hu, Fred Moore, Ben R Miller, James W Elkins
The Montreal Protocol was designed to protect the stratospheric ozone layer by enabling reductions in the abundance of ozone-depleting substances such as chlorofluorocarbons (CFCs) in the atmosphere1-3 . The reduction in the atmospheric concentration of trichlorofluoromethane (CFC-11) has made the second-largest contribution to the decline in the total atmospheric concentration of ozone-depleting chlorine since the 1990s 1 . However, CFC-11 still contributes one-quarter of all chlorine reaching the stratosphere, and a timely recovery of the stratospheric ozone layer depends on a sustained decline in CFC-11 concentrations 1 ...
May 2018: Nature
https://www.readbyqxmd.com/read/29768664/a-four-year-longitudinal-study-examining-psychache-and-suicide-ideation-in-elevated-risk-undergraduates-a-test-of-shneidman-s-model-of-suicidal-behavior
#14
Vanessa Montemarano, Talia Troister, Christine E Lambert, Ronald R Holden
OBJECTIVES: Using a 4-year follow-up design, this research investigated Shneidman's model of psychache (i.e., intense mental pain/anguish) as the cause of suicide. Operationalizing suicidal manifestations using suicide ideation, we evaluated Shneidman's assertion that psychache is the prominent predictor of suicide ideation and that other suicide-related psychological variables associate with suicide ideation only through psychache. METHOD: Eighty-two undergraduates at elevated suicide risk were assessed at baseline and follow-up with measures of suicide ideation and three psychological predictors: depression, hopelessness, and psychache...
May 16, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29768040/myristate-induced-endoplasmic-reticulum-stress-requires-ceramide-synthases-5-6-and-generation-of-c14-ceramide-in-intestinal-epithelial-cells
#15
Songhwa Choi, Justin M Snider, Nicole Olakkengil, Johana M Lambert, Andrea K Anderson, Jessica S Ross-Evans, L Ashley Cowart, Ashley J Snider
Saturated fatty acids (SFAs) have been shown to induce endoplasmic reticulum (ER) stress and chronic inflammatory responses, as well as alter sphingolipid metabolism. Disruptions in ER stress and sphingolipid metabolism have also been implicated in intestinal inflammation. Therefore, to elucidate the roles of SFAs in ER stress and inflammation in intestinal epithelial cells, we examined myristate (C14:0) and palmitate (C16:0). Myristate, but not palmitate, induced ER stress signaling, including activation of inositol-requiring enzyme 1 (IRE1) and X-box binding protein 1 (XBP1) signaling...
May 16, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29767684/ultrasensitive-hiv-1-viral-load-as-a-marker-of-treatment-choice-for-simplification-strategies
#16
Sidonie Lambert-Niclot, Maxime Grude, Jean-Luc Meynard, Anne-Geneviève Marcelin, Marc-Antoine Valantin, Philippe Flandre, Jacques Izopet, Laetitia Moinot, Vincent Bouteloup, Vincent Calvez, Christine Katlama, Pierre-Marie Girard, Laurence Morand-Joubert
Background: We pooled the results of three randomized trials that compared the efficacy of PI/r monotherapy and standard triple therapy as maintenance therapy and evaluated: 1) the distribution of ultrasensitive viral load (USVL) at week 96 (W96), 2) factors associated with virological success (VL<50 copy/mL) at W96, and 3) factors associated with USVL<1 copy/ml (c/ml) at W96. Methods: Virological failure was defined as two consecutive measurements of HIV-1 RNA viral load >50 copies/mL and was analyzed in intention-to-treat...
May 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29766528/reflecting-on-the-past-a-content-analysis-of-family-therapy-research-from-2000-2015
#17
Jennifer J Lambert-Shute, Hoa N Nguyen, Paul W Peterson, Annisa B Pirasteh
In this content analysis, researchers examine articles published from 2000 to 2015 in three family therapy journals, yielding a total of 948 empirical articles. The purpose is to provide an overview of the research being published, assess who is publishing, and investigate the current state of clinical effectiveness research in marriage and family therapy (MFT). Most first authors were affiliated with MFT programs and primarily included diversity and couples in their research. There was a significant increase of research on clinical process-though the number of clinical outcome studies held steady...
May 15, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29765678/a-new-large-squalodelphinid-cetacea-odontoceti-from-peru-sheds-light-on-the-early-miocene-platanistoid-disparity-and-ecology
#18
Giovanni Bianucci, Giulia Bosio, Elisa Malinverno, Christian de Muizon, Igor M Villa, Mario Urbina, Olivier Lambert
The South Asian river dolphin ( Platanista gangetica ) is the only extant survivor of the large clade Platanistoidea, having a well-diversified fossil record from the Late Oligocene to the Middle Miocene. Based on a partial skeleton collected from the Chilcatay Formation (Chilcatay Fm; southern coast of Peru), we report here a new squalodelphinid genus and species, Macrosqualodelphis ukupachai . A volcanic ash layer, sampled near the fossil, yielded the 40 Ar/39 Ar age of 18.78 ± 0.08 Ma (Burdigalian, Early Miocene)...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29764839/lineage-restriction-analyses-in-chip-indicate-myeloid-bias-for-tet2-and-multipotent-stem-cell-origin-for-dnmt3a
#19
Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, Vincent Bourgoin, Luigina Mollica, Marie-Pierre Dubé, Lambert Busque
We analyzed DNA from PMN (granulocytes), CD14+ (monocytes), CD19+ (B-cells) and CD3+ (T-cells) of 107 individuals with clonal hematopoiesis of indeterminate potential (CHIP) to perform lineage restriction analysis of different gene mutations. Individuals were aged 55 to 96 (mean age: 70.0). Three lineage categories were defined: myeloid (PMN±monocytes), myelolympho-B (myeloid and B-cells), multipotent (myeloid, B and T-cells). Six individuals with aberrant patterns were excluded from analysis. Fifty-six had a single DNMT3A mutation, 24 had a single TET2 mutation, 7 had a single mutation in other genes (JAK2, ASXL1, CBL or TP53), and 14 had multiple mutations...
May 15, 2018: Blood
https://www.readbyqxmd.com/read/29764715/the-state-of-adherence-to-hiv-care-in-black-women
#20
Crystal Chapman Lambert, Michael J Mugavero, Yaseen S Najjar, Comfort Enah, Barbara J Guthrie
The purpose of this systematic review was to assess the state of adherence to HIV care such as HIV medication and appointment adherence among Black women in the United States. After a systematic search of CINAHL, PubMed, EMBASE, and clinicialtrials.gov, 26 studies and two ongoing trials met inclusion criteria. Psychosocial factors such as intersectional stigmas and depression were among the salient factors associated with adherence-to-care behaviors in women living with HIV (WLWH). In addition, interpersonal factors such as social support and the patient-provider relationship were frequently associated with adherence-to-care behaviors...
February 21, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
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