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https://www.readbyqxmd.com/read/29161398/role-of-gabaa-receptor-subtypes-in-the-behavioural-effects-of-intravenous-general-anaesthetics
#1
C J Weir, S J Mitchell, J J Lambert
Since the introduction of general anaesthetics into clinical practice, researchers have been mystified as to how these chemically disparate drugs act to produce their dramatic effects on central nervous system function and behaviour. Scientific advances, particularly during the last 25 years, have now begun to reveal the molecular mechanisms underpinning their behavioural effects. For certain i.v. general anaesthetics, such as etomidate and propofol, a persuasive case can now be made that the GABAA receptor, a major inhibitory receptor in the mammalian central nervous system, is an important target...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29159017/gardening-and-age-related-weight-gain-results-from-a-cross-sectional-survey-of-denver-residents
#2
Jill S Litt, Jeffrey Richard Lambert, Deborah H Glueck
This study examined whether gardening modifies the association between age and body mass index (BMI). We used data from the Neighborhood Environments and Health Survey, which was conducted in Denver (N = 469) between 2006 and 2007. We fit two general linear mixed models. The base model had BMI in kg/m(2) as the outcome, and age, an indicator variable for non-gardening status and the age-by-non-gardening status interaction as predictors. The adjusted model included as covariates the potential confounders of education, ethnicity and self-reported health...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29158844/quantitative-imaging-for-targeted-radionuclide-therapy-dosimetry-technical-review
#3
REVIEW
Tiantian Li, Edwin C I Ao, Bieke Lambert, Boudewijn Brans, Stefaan Vandenberghe, Greta S P Mok
Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification...
2017: Theranostics
https://www.readbyqxmd.com/read/29158358/obesity-paradox-in-hypertension-is-this-because-sympathetic-activation-in-obesity-hypertension-takes-a-benign-form
#4
REVIEW
Murray Esler, Gavin Lambert, Markus Schlaich, John Dixon, Carolina Ika Sari, Elisabeth Lambert
No abstract text is available yet for this article.
November 20, 2017: Hypertension
https://www.readbyqxmd.com/read/29158319/royal-society-scientific-meeting-extracellular-vesicles-in-the-tumour-microenvironment
#5
REVIEW
Ryan Charles Pink, Areeg A Elmusrati, Daniel Lambert, David Raul Francisco Carter
Cancer cells do not grow as an isolated homogeneous mass; tumours are, in fact, complex and heterogeneous collections of cancer and surrounding stromal cells, collectively termed the tumour microenvironment. The interaction between cancer cells and stromal cells in the tumour microenvironment has emerged as a key concept in the regulation of cancer progression. Understanding the intercellular dialogue in the tumour microenvironment is therefore an important goal. One aspect of this dialogue that has not been appreciated until recently is the role of extracellular vesicles (EVs)...
January 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29158307/extracellular-vesicles-in-the-tumour-microenvironment
#6
David Raul Francisco Carter, Aled Clayton, Andrew Devitt, Stuart Hunt, Daniel W Lambert
No abstract text is available yet for this article.
January 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29157586/does-comorbid-obstructive-sleep-apnea-impair-the-effectiveness-of-cognitive-and-behavioral-therapy-for-insomnia
#7
Alexander Sweetman, Leon Lack, Sky Lambert, Michael Gradisar, Jodie Harris
AIMS: Comorbid insomnia and obstructive sleep apnea (OSA) represents a highly prevalent and debilitating condition; however, physicians and researchers are still uncertain about the most effective treatment approach. Several research groups have suggested that these patients should initially receive treatment for their insomnia before the sleep apnea is targeted. The current study aims to determine whether Cognitive and Behavioral Therapy for Insomnia (CBT-i) can effectively treat insomnia in patients with comorbid OSA and whether its effectiveness is impaired by the presence of OSA...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29157311/peripheral-and-local-predictive-immune-signatures-identified-in-a-phase-ii-trial-of-ipilimumab-with-carboplatin-paclitaxel-in-unresectable-stage-iii-or-stage-iv-melanoma
#8
Rahima Jamal, Réjean Lapointe, Eftihia Cocolakis, Paméla Thébault, Shirin Kazemi, Jennifer E Friedmann, Jeanne Dionne, Jean-François Cailhier, Karl Bélanger, Jean-Pierre Ayoub, Huy Le, Caroline Lambert, Jida El-Hajjar, Léon C van Kempen, Alan Spatz, Wilson H Miller
BACKGROUND: Checkpoint blockade with ipilimumab provides long-term survival to a significant proportion of patients with metastatic melanoma. New approaches to increase survival and to predict which patients will benefit from treatment are needed. This phase II trial combined ipilimumab with carboplatin/paclitaxel (CP) to assess its safety, efficacy, and to search for peripheral and tumor-based predictive biomarkers. METHODS: Thirty patients with untreated unresectable/metastatic melanoma were treated with ipilimumab and CP...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29155657/frontline-field-epidemiology-training-programs-as-a-strategy-to-improve-disease-surveillance-and-response
#9
A McKenzie André, Augusto Lopez, Samantha Perkins, Stephanie Lambert, Lesley Chace, Nestor Noudeke, Aissatou Fall, Biagio Pedalino
Since 1980, Field Epidemiology Training Programs (FETPs) have trained highly qualified field epidemiologists to work for ministries of health (MOH) around the world. However, the 2013-2015 Ebola epidemic in West Africa, which primarily affected Guinea, Liberia, and Sierra Leone, demonstrated a lack of field epidemiologists at the local levels. Trained epidemiologists at these levels could have detected the Ebola outbreak earlier. In 2015, the US Centers for Disease Control and Prevention (CDC) launched FETP-Frontline, a 3-month field training program targeting local MOH staff in 24 countries to augment local public health capacity...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155654/surveillance-training-for-ebola-preparedness-in-c%C3%A3-te-d-ivoire-guinea-bissau-senegal-and-mali
#10
Victor M Cáceres, Sekou Sidibe, McKenzie Andre, Denise Traicoff, Stephanie Lambert, Melanie King, Ditu Kazambu, Augusto Lopez, Biagio Pedalino, Dionisio J Herrera Guibert, Peter Wassawa, Placido Cardoso, Bernard Assi, Alioune Ly, Bouyagui Traore, Frederick J Angulo, Linda Quick
The 2014-2015 epidemic of Ebola virus disease in West Africa primarily affected Guinea, Liberia, and Sierra Leone. Several countries, including Mali, Nigeria, and Senegal, experienced Ebola importations. Realizing the importance of a trained field epidemiology workforce in neighboring countries to respond to Ebola importations, the Centers for Disease Control and Prevention Field Epidemiology Training Program unit implemented the Surveillance Training for Ebola Preparedness (STEP) initiative. STEP was a mentored, competency-based initiative to rapidly build up surveillance capacity along the borders of the at-risk neighboring countries Côte d'Ivoire, Mali, Senegal, and Guinea-Bissau...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29154029/basic-numerical-competences-in-large-scale-assessment-data-structure-and-long-term-relevance
#11
Stefa Hirsch, Katharina Lambert, Karien Coppens, Korbinian Moeller
Basic numerical competences are seen as building blocks for later numerical and mathematical achievement. The current study aimed at investigating the structure of early numeracy reflected by different basic numerical competences in kindergarten and its predictive value for mathematical achievement 6 years later using data from large-scale assessment. This allowed analyses based on considerably large sample sizes (N > 1700). A confirmatory factor analysis indicated that a model differentiating five basic numerical competences at the end of kindergarten fitted the data better than a one-factor model of early numeracy representing a comprehensive number sense...
November 15, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29153057/sex-dependent-influence-of-developmental-toxicant-exposure-on-group-b-streptococcus-mediated-preterm-birth-in-a-murine-model
#12
Tianbing Ding, Lauren A Lambert, David M Aronoff, Kevin G Osteen, Kaylon L Bruner-Tran
Infectious agents are a significant risk factor for preterm birth (PTB); however, the simple presence of bacteria is not sufficient to induce PTB in most women. Human and animal data suggest that environmental toxicant exposures may act in concert with other risk factors to promote PTB. Supporting this "second hit" hypothesis, we previously demonstrated exposure of fetal mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to an increased risk of spontaneous and infection-mediated PTB in adult animals...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29153008/teaching-health-versus-treating-illness-the-efficacy-of-three-principles-correctional-counseling-with-people-in-an-english-prison
#13
Thomas M Kelley, Jacqueline Hollows, Eric G Lambert, Dennis M Savard, Jack Pransky
Three principles correctional counseling (3PCC) posits that people in prison have inner mental health they have obscured to varying degrees with their own thinking. 3PCC further posits that people in prison can rekindle and sustain this inner health via understanding how three psychospiritual principles-Universal Mind, consciousness, and thought-coalesce to form people's psychological experience. We review the three principles and explain how exposure to these principles can lead to improved mental health and improved behavior...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29151617/poly-arylene-ethynylene-alt-arylene-vinylene-s-based-on-anthanthrone-and-its-derivatives-synthesis-and-photophysical-electrochemical-electroluminescent-and-photovoltaic-properties
#14
Suru Vivian John, Věra Cimrová, Christoph Ulbricht, Veronika Pokorná, Aleš Růžička, Jean-Benoit Giguère, Antoine Lafleur-Lambert, Jean-François Morin, Emmanuel Iwuoha, Daniel Ayuk Mbi Egbe
Anthanthrone and its derivatives are large polycyclic aromatic compounds (PACs) that pose a number of challenges for incorporation into the structure of soluble conjugated polymers. For the first time, this group of PACs was employed as the building blocks for the synthesis of copolymers (P1-P5) based on poly[(arylene ethynylene)-alt-(arylene vinylene)]s backbone (-Ph-C≡C-Anth-C≡C-Ph-CH=CH-Ph-CH=CH-) n . During the synthesis of P1-P5, different alkyloxy side chains were incorporated in order to tune the properties of the polymers...
November 14, 2017: Macromolecules
https://www.readbyqxmd.com/read/29151280/oral-nutritional-supplementation-in-patients-undergoing-peritoneal-dialysis-a-randomised-crossover-pilot-study
#15
Karen M Salamon, Kelly Lambert
BACKGROUND: Malnutrition is a significant problem in those undergoing peritoneal dialysis (PD). Factors such as gastrointestinal (GI) symptoms and the need for a fluid reduced diet can limit tolerance and thereby the efficacy of oral nutritional supplements to treat malnutrition. OBJECTIVES: To evaluate the acceptability and impact of two different forms of oral nutrition supplementation for 16 weeks on nutritional markers and quality of life of malnourished patients undergoing PD...
November 19, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/29150804/using-citrus-aurantifolia-essential-oil-for-the-potential-biocontrol-of-colocasia-esculenta-taro-leaf-blight-caused-by-phytophthora-colocasiae
#16
Séverin Nguemezi Tchameni, Staelle Njamou Mbiakeu, Modeste Lambert Sameza, Pierre Michel Dongmo Jazet, François Tchoumbougnang
The aim of this work was to evaluate the antimicrobial activities of leaves and epicarp of Citrus aurantifolia essential oil against Phytophthora colocasiae, the causative agent of taro leaf blight. Oils were extracted by hydrodistillation, and their chemical composition was determined by gas chromatography and gas chromatography coupled with mass spectrometry. Antimicrobial activities of oils were tested in vitro against mycelium growth and sporangium production. In situ tests were done on healthy taro leaves, and the necrosis symptoms were evaluated...
November 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29149283/multivalent-rotavirus-vaccine-and-wild-type-rotavirus-strain-shedding-in-australian-infants-a-birth-cohort-study
#17
Suifang Ye, David M Whiley, Robert S Ware, Carl D Kirkwood, Stephen B Lambert, Keith Grimwood
Background: Rotavirus vaccines have reduced moderate-to-severe gastroenteritis episodes in infants and young children. Nevertheless, knowledge gaps exist concerning rotavirus vaccine shedding and vaccine impact upon mild and asymptomatic wild-type infections. Our primary objective was to investigate vaccine shedding in Australian infants where the multivalent human-bovine reassortant rotavirus vaccine, RotaTeq®, was part of the routine vaccination schedule. Methods: The Observational Research in Childhood Infectious Diseases (ORChID) birth cohort study was conducted in Brisbane, Australia, from September 2010 to October 2014...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29148885/self-clearance-of-pestivirus-in-a-pyrenean-chamois-rupicapra-pyrenaica-population
#18
Emmanuelle Gilot-Fromont, Mathieu Garel, Philippe Gibert, Sébastien Lambert, Pierre Menaut, Brigitte Bonetti, Yvette Game, Gaël Reynaud, Kévin Foulché
Understanding the dynamics of host-pathogen interaction is key to the management of epidemics. A pestivirus belonging to the border disease virus group 4 emerged around 2001 in Pyrenean chamois (Rupicapra pyrenaica) in Spain and France. The virus had significant demographic impact in some populations, but it was less harmful and more endemic in other places. The determinants of these local variations are still unclear. Here, we documented empirical evidence of self-clearance of the virus in a chamois population in France...
November 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29148395/bourbon-virus-in-field-collected-ticks-missouri-usa
#19
Harry M Savage, Kristen L Burkhalter, Marvin S Godsey, Nicholas A Panella, David C Ashley, William L Nicholson, Amy J Lambert
Bourbon virus (BRBV) was first isolated in 2014 from a resident of Bourbon County, Kansas, USA, who died of the infection. In 2015, an ill Payne County, Oklahoma, resident tested positive for antibodies to BRBV, before fully recovering. We retrospectively tested for BRBV in 39,096 ticks from northwestern Missouri, located 240 km from Bourbon County, Kansas. We detected BRBV in 3 pools of Amblyomma americanum (L.) ticks: 1 pool of male adults and 2 pools of nymphs. Detection of BRBV in A. americanum, a species that is aggressive, feeds on humans, and is abundant in Kansas and Oklahoma, supports the premise that A...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29146748/stable-isotope-kinetic-study-of-apom-apolipoprotein-m
#20
Mikaël Croyal, Stéphanie Billon-Crossouard, Sophie Goulitquer, Audrey Aguesse, Luis León, Fanta Fall, Maud Chétiveaux, Thomas Moyon, Valentin Blanchard, Khadija Ouguerram, Gilles Lambert, Estelle Nobécourt, Michel Krempf
OBJECTIVE: ApoM (apolipoprotein M) binds primarily to high-density lipoprotein before to be exchanged with apoB (apolipoprotein B)-containing lipoproteins. Low-density lipoprotein (LDL) receptor-mediated clearance of apoB-containing particles could influence plasma apoM kinetics and decrease its antiatherogenic properties. In humans, we aimed to describe the interaction of apoM kinetics with other components of lipid metabolism to better define its potential benefit on atherosclerosis...
November 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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