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https://www.readbyqxmd.com/read/28526914/finite-element-method-simulating-temperature-distribution-in-skin-induced-by-980-nm-pulsed-laser-based-on-pain-stimulation
#1
Han Wang, Xiao-Xi Dong, Ji-Chun Yang, He Huang, Ying-Xin Li, Hai-Xia Zhang
For predicting the temperature distribution within skin tissue in 980-nm laser-evoked potentials (LEPs) experiments, a five-layer finite element model (FEM-5) was constructed based on Pennes bio-heat conduction equation and the Lambert-Beer law. The prediction results of the FEM-5 model were verified by ex vivo pig skin and in vivo rat experiments. Thirty ex vivo pig skin samples were used to verify the temperature distribution predicted by the model. The output energy of the laser was 1.8, 3, and 4.4 J. The laser spot radius was 1 mm...
May 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28526552/anisometropia-at-age-5-years-after-unilateral-intraocular-lens-implantation-during-infancy-in-the-infant-aphakia-treatment-study-iats
#2
David Weakley, George Cotsonis, M Edward Wilson, David A Plager, Edward G Buckley, Scott R Lambert
PURPOSE: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. DESIGN: Prospective randomized clinical trial METHODS: Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8D (infants 28 to <48 days of age) or +6D (infants 48-210 days of age). Anisometropia was calculated at age 5 years...
May 16, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28526367/discovery-of-a-novel-aminopyrazine-series-as-selective-pi3k%C3%AE-inhibitors
#3
Bernard Barlaam, Sabina Cosulich, Martina Fitzek, Hervé Germain, Stephen Green, Lyndsey L Hanson, Craig S Harris, Urs Hancox, Kevin Hudson, Christine Lambert-van der Brempt, Maryannick Lamorlette, Françoise Magnien, Gilles Ouvry, Ken Page, Linette Ruston, Lara Ward, Bénédicte Delouvrié
We report the discovery of a novel aminopyrazine series of PI3Kα inhibitors, designed by hybridizing two known scaffolds of PI3K inhibitors. We describe the progress achieved from the first compounds plagued with poor general kinase selectivity to compounds showing high selectivity for PI3Kα over PI3Kβ and excellent general kinase selectivity. This effort culminated with the identification of compound 5 displaying high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration...
May 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28526091/a-pre-therapeutic-coating-for-medical-devices-that-prevents-the-attachment-of-candida-albicans
#4
Diego Vargas-Blanco, Aung Lynn, Jonah Rosch, Rony Noreldin, Anthony Salerni, Christopher Lambert, Reeta P Rao
BACKGROUND: Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Efficient adhesion initiates formation of aggressive biofilms that are difficult to treat. Therefore, inhibitors of adhesion are important for drug development and likely to have a broad spectrum efficacy against many fungal pathogens...
May 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28524918/urotensin-ii-peptidomimetic-incorporating-a-non-reducible-1-5-triazole-disulfide-bond-reveals-a-pseudo-irreversible-covalent-binding-mechanism-to-the-urotensin-g-protein-coupled-receptor
#5
Salvatore Pacifico, Aidan Kerckhoffs, Andrew J Fallow, Rachel E Foreman, Remo Guerrini, John McDonald, David G Lambert, Andrew G Jamieson
The urotensin-II receptor (UTR) is a class A GPCR that predominantly binds to the pleiotropic cyclic peptide urotensin-II (U-II). U-II is constrained by a disulfide bridge that induces a β-turn structure and binds pseudo-irreversibly to UTR and is believed to result in a structural rearrangement of the receptor. However, it is not well understood how U-II binds pseudo-irreversibly and the nature of the reorganization of the receptor that results in G-protein activation. Here we describe a series of U-II peptidomimetics incorporating a non-reducible disulfide bond structural surrogate to investigate the feasibility that native U-II binds to the G protein-coupled receptor through disulfide bond shuffling as a mechanism of covalent interaction...
May 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28524803/maternal-and-early-life-nutrition-and-physical-activity-setting-the-research-and-intervention-agenda-for-addressing-the-double-burden-of-malnutrition-in-south-african-children
#6
A Prioreschi, S Wrottesley, C E Draper, S A Tomaz, C J Cook, E D Watson, M N M Van Poppel, R Said-Mohamed, S A Norris, E V Lambert, L K Micklesfield
Early life is important for later health outcomes, yet there are few studies which adequately address all of the potential early life insults that may affect later life health and growth trajectories. This is particularly evident in low- to middle-income countries such as South Africa, where women of childbearing age are particularly vulnerable to high levels of physical inactivity, malnutrition, and obesity. Pregnancy may therefore be an opportune time to change behaviours and improve maternal and offspring health outcomes, and decrease the inter-generational transfer of risk...
2017: Global Health Action
https://www.readbyqxmd.com/read/28524542/negative-schemata-about-the-self-and-others-and-paranoid-ideation-in-at-risk-states-and-those-with-persisting-positive-symptoms
#7
Hendrik Müller, Walter de Millas, Wolfgang Gaebel, Jutta Herrlich, Alkomiet Hasan, Birgit Janssen, Georg Juckel, Anne Karow, Tilo Kircher, Stefanie Kiszkenow-Bäker, Stefan Klingberg, Joachim Klosterkötter, Seza Krüger-Özgürdal, Martin Lambert, Marion Lautenschlager, Wolfgang Maier, Tanja Maria Michel, Stefanie Mehl, Bernhard W Müller, Verena Pützfeld, Franziska Rausch, Michael Riedel, Gudrun Sartory, Frank Schneider, Michael Wagner, Georg Wiedemann, Andreas Wittorf, Thomas Wobrock, Wolfgang Wölwer, Mathias Zink, Andreas Bechdolf
BACKGROUND: The objective of this study is to test the conflicting theories concerning the association of negative self and other schemata and paranoid ideation. METHODS: A risk-based approach, including risk stratification, is used to gain insight into the association of the negative self and other schemata that may be shared by individuals or differentiate between individuals at clinical high risk (CHR) for a first-episode psychosis and those with full-blown psychosis...
May 19, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28523496/imaging-ms-of-rodent-ocular-tissues-and-the-optic-nerve
#8
David M G Anderson, Wendi Lambert, David J Calkins, Zsolt Ablonczy, Rosalie K Crouch, Richard M Caprioli, Kevin L Schey
The visual system is comprised of many specialized cell types that are essential for relaying sensory information about an animal's surroundings to the brain. The cells present in ocular tissue are notoriously delicate, making it particularly challenging to section thin slices of unfixed tissue. Maintaining the morphology of the native tissue is crucial for accurate observations by either conventional staining techniques or in this instance matrix-assisted laser desorption ionization (MALDI IMS) or imaging using mass spectrometry...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28516451/evidence-that-eating-baked-egg-or-milk-influences-egg-or-milk-allergy-resolution-a-systematic-review
#9
REVIEW
R Lambert, K E C Grimshaw, B Ellis, J Jaitly, G Roberts
BACKGROUND: It has been proposed that the frequent ingestion of baked hen's egg or cow's milk accelerates the resolution of hen's egg or cow's milk allergy. This practice is being introduced into clinical practice. OBJECTIVE: To systematically review the evidence to determine whether the introduction of baked hen's egg or cow's milk into the diet of children with hen's egg or cow's milk allergies respectively leads to a larger proportion of children outgrowing these allergies than expected...
May 17, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28515776/hormonally-active-phytochemicals-and-vertebrate-evolution
#10
Max R Lambert, Thea M Edwards
Living plants produce a diversity of chemicals that share structural and functional properties with vertebrate hormones. Wildlife species interact with these chemicals either through consumption of plant materials or aquatic exposure. Accumulating evidence shows that exposure to these hormonally active phytochemicals (HAPs) often has consequences for behavior, physiology, and fecundity. These fitness effects suggest there is potential for an evolutionary response by vertebrates to HAPs. Here, we explore the toxicological HAP-vertebrate relationship in an evolutionary framework and discuss the potential for vertebrates to adapt to or even co-opt the effects of plant-derived chemicals that influence fitness...
June 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28513617/the-perceived-impact-of-the-european-registration-system-for-genetic-counsellors-and-nurses
#11
Milena Paneque, Ramona Moldovan, Christophe Cordier, Clara Serra-Juhé, Irene Feroce, Sara Pasalodos, Emmanuelle Haquet, Debby Lambert, Inga Bjørnevoll, Heather Skirton
The aim of the European Board of Medical Genetics has been to develop and promote academic and professional standards necessary in order to provide competent genetic counselling services. The aim of this study was to explore the impact of the European registration system for genetic nurses and counsellors from the perspectives of those professionals who have registered. Registration system was launched in 2013. A cross-sectional, online survey was used to explore the motivations and experiences of those applying for, and the effect of registration on their career...
May 17, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28512751/giant-torturous-left-circumflex-artery-draining-to-the-right-atrium
#12
Lenka Eremiasova, Petr Kuchynka, Lukas Lambert, Tomas Palecek
Coronary artery anomalies represent a diverse group of congenital disorders characterized by abnormalities of coronary arteries anatomy. We describe an extremely rare case of giant torturous left circumflex artery draining to the right atrium manifesting by palpitations and atrial fibrillation.
May 16, 2017: Echocardiography
https://www.readbyqxmd.com/read/28511833/isotretinoin-in-retrospect
#13
Ayse Serap Karadag, Lawrence Charles Parish, Wm Clark Lambert
No abstract text is available yet for this article.
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28511721/socioeconomic-status-and-dietary-patterns-in-children-from-around-the-world-different-associations-by-levels-of-country-human-development
#14
Taru Manyanga, Mark S Tremblay, Jean-Philippe Chaput, Peter T Katzmarzyk, Mikael Fogelholm, Gang Hu, Rebecca Kuriyan, Anura Kurpad, Estelle V Lambert, Carol Maher, Jose Maia, Victor Matsudo, Timothy Olds, Vincent Onywera, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Pei Zhao, Vera Mikkila, Stephanie T Broyles
BACKGROUND: Although 'unhealthy' diet is a well-known risk factor for non-communicable diseases, its relationship with socio-economic status (SES) has not been fully investigated. Moreover, the available research has largely been conducted in countries at high levels of human development. This is the first study to examine relationships among dietary patterns and SES of children from countries spanning a wide range of human development. METHODS: This was a multinational cross-sectional study among 9-11 year-old children (n = 6808) from urban/peri-urban sites across 12 countries...
May 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28510646/benefit-of-switching-dual-antiplatelet-therapy-after-acute-coronary-syndrome-the-topic-timing-of-platelet-inhibition-after-acute-coronary-syndrome-randomized-study
#15
Thomas Cuisset, Pierre Deharo, Jacques Quilici, Thomas W Johnson, Stéphanie Deffarges, Clémence Bassez, Guillaume Bonnet, Laurent Fourcade, Jean Philippe Mouret, Marc Lambert, Valentine Verdier, Pierre Emmanuel Morange, Marie Christine Alessi, Jean Louis Bonnet
Aims: Newer P2Y12 blockers (prasugrel and ticagrelor) demonstrated significant ischaemic benefit over clopidogrel after acute coronary syndrome (ACS). However, both drugs are associated with an increase in bleeding complications. The objective of the present study was to evaluate the benefit of switching dual antiplatelet therapy (DAPT) from aspirin plus a newer P2Y12 blocker to aspirin plus clopidogrel 1 month after ACS. Methods and results: We performed an open-label, monocentric, and randomized trial...
May 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28509610/development-of-culture-sensitive-clinical-teacher-evaluation-sheet-in-the-japanese-context
#16
Makoto Kikukawa, Renee E Stalmeijer, Tomoya Okubo, Kikuko Taketomi, Sei Emura, Yasushi Miyata, Motofumi Yoshida, Lambert Schuwirth, Albert J J A Scherpbier
AIM: Many instruments for evaluating clinical teaching have been developed, albeit most in Western countries. This study aims to develop a validated cultural and local context sensitive instrument for clinical teachers in an East Asian setting (Japan), Japanese Clinical Teacher Evaluation Sheet (JaCTES). METHODS: A multicenter, cross-sectional evaluation study was conducted. We collected a total of 1368 questionnaires on 304 clinical teachers, completed by residents in 16 teaching hospitals...
May 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28507235/assessing-the-strength-of-cardiac-and-sympathetic-baroreflex-controls-via-transfer-entropy-during-orthostatic-challenge
#17
Alberto Porta, Andrea Marchi, Vlasta Bari, Beatrice De Maria, Murray Esler, Elisabeth Lambert, Mathias Baumert
The study assesses the strength of the causal relation along baroreflex (BR) in humans during an incremental postural challenge soliciting the BR. Both cardiac BR (cBR) and sympathetic BR (sBR) were characterized via BR sequence approaches from spontaneous fluctuations of heart period (HP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and muscle sympathetic nerve activity (MSNA). A model-based transfer entropy method was applied to quantify the strength of the coupling from SAP to HP and from DAP to MSNA...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28506868/drug-disease-modeling-in-the-pharmaceutical-industry-where-mechanistic-systems-pharmacology-and-statistical-pharmacometrics-meet
#18
Gabriel Helmlinger, Nidal Al-Huniti, Sergey Aksenov, Kirill Peskov, Melissa Hallow, Lulu Chu, David Boulton, Ulf Eriksson, Bengt Hamrén, Craig Lambert, Eric Masson, Helen Tomkinson, Donald Stanski
Modeling & simulation (M&S) methodologies are established quantitative tools, which have proven to be useful in supporting the research, development (R&D), regulatory approval, and marketing of novel therapeutics. Applications of M&S help design efficient studies and interpret their results in context of all available data and knowledge to enable effective decision-making during the R&D process. In this mini-review, we focus on two sets of modeling approaches: population-based models, which are well-established within the pharmaceutical industry today, and fall under the discipline of clinical pharmacometrics (PMX); and systems dynamics models, which encompass a range of models of (patho-)physiology amenable to pharmacological intervention, of signaling pathways in biology, and of substance distribution in the body (today known as physiologically-based pharmacokinetic models) - which today may be collectively referred to as quantitative systems pharmacology models (QSP)...
May 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28506432/the-icuc-%C3%A2-app-can-it-pave-the-way-for-quality-control-and-transparency-in-medicine
#19
EDITORIAL
Pietro Regazzoni, Peter V Giannoudis, Simon Lambert, Alberto Fernandez, Stephan M Perren
No abstract text is available yet for this article.
June 2017: Injury
https://www.readbyqxmd.com/read/28506115/predictors-of-work-participation-for-m%C3%A4-ori-three-months-after-injury
#20
Emma H Wyeth, Brett Maclennan, Michelle Lambert, Gabrielle Davie, Rebbecca Lilley, Sarah Derrett
An important rehabilitation outcome for injured Māori is timely sustainable return to work. This paper identifies the factors influencing working after injury in an attempt to reduce the individual, social and economic costs. Māori participants in the Prospective Outcomes of Injury Study were interviewed, about pre-injury and injury-related factors. Among Māori participants, 521 were working for pay prior to injury; 64% were working three months post-injury. Factors identified, using modified Poisson regression, that predicted working include: financial security (aRR = 1...
May 16, 2017: Archives of Environmental & Occupational Health
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