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Cervical cancer, ovarian cancer, uterine cancer

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https://www.readbyqxmd.com/read/29742673/trends-in-place-of-death-among-patients-with-gynecologic-cancer-in-the-united-states
#1
Katherine Hicks-Courant, Alexander Melamed, Michael J Worley, Young Bae Kim, John O Schorge, J Alejandro Rauh-Hain
OBJECTIVE: To describe the change over time in place of death (hospital, home, hospice) among all women in the United States who died of gynecologic malignancies and compare them with other leading causes of female cancer deaths. METHODS: This is a retrospective cross-sectional study using national death certificate data from the Mortality Multiple Cause-of-Death Public Use Record Data. All women who died from gynecologic, breast, lung, and colorectal cancers were identified according to International Classification of Diseases, 10 Revision, cause of death from 2003 to 2015...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742668/effects-of-the-affordable-care-act-on-young-women-with-gynecologic-cancers
#2
Anna Jo Bodurtha Smith, Amanda N Fader
OBJECTIVE: To evaluate the effects of the dependent coverage mandate of the 2010 Affordable Care Act (ACA) on insurance status, stage at diagnosis, and receipt of fertility-sparing treatment among young women with gynecologic cancer. METHODS: We used a difference-in-differences design to assess insurance status, stage at diagnosis (stage I-II vs III-IV), and receipt of fertility-spearing treatment before and after the 2010 ACA among young women aged 21-26 years vs women aged 27-35 years...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29706033/breast-and-reproductive-cancers-in-the-transgender-population-a-systematic-review
#3
Rachel Joint, Zhong Eric Chen, Sharon Cameron
BACKGROUND: The medical transition undergone by a transgender person may influence their risk of breast or reproductive cancer. OBJECTIVES: To assess breast and reproductive cancer prevalence in the transgender population. To elucidate any associations between gender-affirming hormones and risk of these cancers. SEARCH STRATEGY: Following registration of review protocol with PROSPERO, five databases were searched. SELECTION CRITERIA: Included studies investigated breast, ovarian, uterine, cervical, vaginal, neovaginal, testicular and prostate cancer in the transgender population...
April 28, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29705969/the-impact-of-complete-embedding-of-remaining-tissue-in-gynecological-lymph-node-dissection-specimen-in-surgical-pathology-on-lymph-node-yield-is-it-clinically-relevant
#4
Julia Andruszkow, Ivo Meinhold-Heerlein, Brigitte Winkler, Benjamin Bruno, Ruth Knüchel, Jörg Jäkel
The assessment of nodal metastases in gynecological surgical specimen is an important staging parameter, directing further therapeutic procedures. Since the number of lymph nodes (LNs) removed is seen as an indicator of surgical and pathological quality, the demand for higher lymph node (LN) counts is raising. The goal of this prospective study was the comparison between lymph node counts of macroscopically detectable LNs and the LN yield by complete embedding and proceeding of all submitted LN-containing tissue in the pathology laboratory...
April 28, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29687925/melanoma-thyroid-cancer-and-gynecologic-cancers-in-a-cohort-of-female-flight-attendants
#5
Lynne E Pinkerton, Misty J Hein, Jeri L Anderson, Annette Christianson, Mark P Little, Alice J Sigurdson, Mary K Schubauer-Berigan
BACKGROUND: Flight attendants may have an increased risk of some cancers from occupational exposure to cosmic radiation and circadian disruption. METHODS: The incidence of thyroid, ovarian, and uterine cancer among ∼6000 female flight attendants compared to the US population was evaluated via life table analyses. Associations of these cancers, melanoma, and cervical cancer with cumulative cosmic radiation dose and metrics of circadian disruption were evaluated using Cox regression...
April 24, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29621040/concomitant-repair-of-pelvic-floor-disorders-in-women-undergoing-surgery-for-gynecologic-malignancies
#6
Katarzyna Bochenska, Margaret Mueller, Julia Geynisman-Tan, Alix Leader-Cramer, Bhumy Davé, Christina Lewicky-Gaupp, Kimberly Kenton
OBJECTIVE: The aims of this study were to determine the rate and describe 30-day postoperative complications of concomitant pelvic organ prolapse and/or urinary incontinence (POPUI) procedures in women undergoing surgery for a gynecologic malignancy. METHODS: Women who underwent surgical intervention for a gynecologic malignancy between 2010 and 2014 were identified using postoperative International Classification of Diseases, Ninth Revision codes 179.0 to 184.9 in the American College of Surgeons National Surgical Quality Improvement Program database...
April 4, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29605053/a-contemporary-framework-of-health-equity-applied-to-gynecologic-cancer-care-a-society-of-gynecologic-oncology-evidenced-based-review
#7
REVIEW
Sarah M Temkin, B J Rimel, Amanda S Bruegl, Camille C Gunderson, Anna L Beavis, Kemi M Doll
Health disparities are defined as the preventable difference in the burden of disease, injury, and violence, or opportunity to achieve optimal health that socially disadvantaged populations experience compared to the population as a whole. Disparities in incidence and cancer outcomes for women with gynecologic malignancies have been well described particularly for American women of Black race. The etiology of these disparities has been tied to socio-economics, cultural, educational and genetic factors. While access to high quality treatment has been primarily linked to survival from cervical and ovarian cancer, innate biologic distinctions have been principally cited as reasons for differences in incidence and mortality in cancers of the uterine corpus...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29544627/the-ovarian-cycle
#8
JoAnne S Richards
The "ovarian cycle" is an exquisite and dynamic endocrine system that includes ovarian events, hypothalamic-pituitary interactions, uterine endometrial and myometrial changes during implantation and pregnancy, cervical alterations in structure, and breast development. The ovarian cycle and the steroid hormones produced by the ovary also impact epithelial cancer development in the ovary, uterus, cervix, and breast. This chapter provides a personal view of recent developments that occur in this complex endocrine environment...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29534229/ceramide-1-phosphate-has-protective-properties-against-cyclophosphamide-induced-ovarian-damage-in-a-mice-model-of-premature-ovarian-failure
#9
Natalia Pascuali, Leopoldina Scotti, Mariana Di Pietro, Gonzalo Oubiña, Diana Bas, María May, Antonio Gómez Muñoz, Patricia S Cuasnicú, Débora J Cohen, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
STUDY QUESTION: Is ceramide-1-phosphate (C1P) an ovarian protective agent during alkylating chemotherapy? SUMMARY ANSWER: Local administration of C1P drastically reduces ovarian damage induced by cyclophosphamide (Cy) via protection of follicular reserve, restoration of hormone levels, inhibition of apoptosis and improvement of stromal vasculature, while protecting fertility, oocyte quality and uterine morphology. WHAT IS KNOWN ALREADY: Cancer-directed therapies cause accelerated loss of ovarian reserve and lead to premature ovarian failure (POF)...
March 9, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29511377/differences-in-c-type-lectin-receptors-and-their-adaptor-molecules-in-the-peritoneal-fluid-of-patients-with-endometriosis-and-gynecologic-cancers
#10
Seung Geun Yeo, Yong Sung Won, Sang Hoon Kim, Dong Choon Park
Endometriosis, although not malignant, has clinically demonstrated properties of invasiveness and metastasis. The pathogenesis of endometriosis, however, has not yet been elucidated. The immunological differences between endometriosis and malignant gynecologic tumors were analyzed by assessing C-type lectin receptors, which are associated with innate immunity, and immunoglobulin secretion, which is associated with B cell adaptive immunity, in the peritoneal fluid of these patients. Peritoneal fluid samples were obtained from 42 patients with benign masses (control group), 38 with endometriosis, and 43 with gynecologic (ovarian, uterine, and cervical) cancers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29482750/fdg-pet-assessment-of-other-gynecologic-cancers
#11
REVIEW
Silvana Faria, Catherine Devine, Chitra Viswanathan, Sanaz Javadi, Brinda Rao Korivi, Priya R Bhosale
PET and PET/computed tomography play a role in the staging, monitoring of response to therapy, and surveillance for cervical and ovarian cancers. Currently, it is also an integral part of the assessment of patients with endometrial cancer and other gynecologic malignancies, such as vaginal and vulvar cancers and uterine sarcomas. In this article, we discuss in detail and highlight the potential role of PET and PET/computed tomography in evaluating these gynecologic malignancies using illustrative cases with relevant imaging findings...
April 2018: PET Clinics
https://www.readbyqxmd.com/read/29468855/major-clinical-research-advances-in-gynecologic-cancer-in-2017
#12
REVIEW
Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, Keun Yong Eom, Maj Kamille Kjeldsen, Mansoor Raza Mirza, Jae Weon Kim
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29413464/harnessing-genomics-to-improve-outcomes-for-women-with-cancer-in-india-key-priorities-for-research
#13
REVIEW
Sudha Sundar, Poonam Khetrapal-Singh, Jon Frampton, Edward Trimble, Preetha Rajaraman, Ravi Mehrotra, Roopa Hariprasad, Arindam Maitra, Paramjit Gill, Vanita Suri, Radhika Srinivasan, Gurpreet Singh, J S Thakur, Preet Dhillon, Jean-Baptiste Cazier
Cumulatively, breast, cervical, ovarian, and uterine cancer account for more than 70% of cancers in women in India. Distinct differences in the clinical presentation of women with cancer suggest underlying differences in cancer biology and genetics. The peak age of onset of breast and ovarian cancer appears to be a decade earlier in India (age 45-50 years) than in high-income countries (age >60 years). Understanding these differences through research to develop diagnosis, screening, prevention, and treatment frameworks that ar e specific to the Indian population are critical and essential to improving women's health in India...
February 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29373116/uncommon-hereditary-gynaecological-tumour-syndromes-pathological-features-in-tumours-that-may-predict-risk-for-a-germline-mutation
#14
REVIEW
Karuna Garg, Anthony N Karnezis, Joseph T Rabban
The most common hereditary gynaecological tumour syndromes are hereditary breast and ovarian cancer syndrome and Lynch syndrome. However, pathologists also may encounter gynaecological tumours in women with rare hereditary syndromes. Many of these tumours exhibit distinctive gross and microscopic features that are associated with a risk for an inherited gene mutation. The sensitivity and specificity of these tumour pathology features for predicting an inherited mutation vary depending on the syndrome. By recognising these tumour features, pathologists may potentially contribute to the diagnosis of an unsuspected syndrome by recommending referral of the patient for formal risk assessment by genetic counselling...
February 2018: Pathology
https://www.readbyqxmd.com/read/29353371/a-systematic-assessment-of-google-search-queries-and-readability-of-online-gynecologic-oncology-patient-education-materials
#15
Alexandra Martin, J Ryan Stewart, Jeremy Gaskins, Erin Medlin
The Internet is a major source of health information for gynecologic cancer patients. In this study, we systematically explore common Google search terms related to gynecologic cancer and calculate readability of top resulting websites. We used Google AdWords Keyword Planner to generate a list of commonly searched keywords related to gynecologic oncology, which were sorted into five groups (cervical cancer, ovarian cancer, uterine cancer, vulvar cancer, vaginal cancer) using five patient education websites from sgo...
January 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29325966/role-of-intraoperative-ultrasound-to-extend-the-application-of-minimally-invasive-surgery-for-treatment-of-recurrent-gynecologic-cancer
#16
Floriana Mascilini, Lorena Quagliozzi, Francesca Moro, Maria Cristina Moruzzi, Valerio Gallotta, Salvatore Gueli Alletti, Giovanni Scambia, Antonia Carla Testa, Anna Fagotti
STUDY OBJECTIVE: To describe the potential role of intraoperative ultrasound (IOUS) in the detection and localization of recurrent disease in gynecologic cancer patients during minimally invasive surgery (MIS). DESIGN: A prospective cohort study (Canadian Task Force classification II-1). SETTING: A university hospital. PATIENTS: Fifty-one gynecologic cancer patients with isolated recurrent disease. INTERVENTIONS: IOUS during secondary cytoreductive surgery (SCS) by MIS...
January 8, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29303934/calcification-a-disregarded-or-ignored-issue-in-the-gynecologic-tumor-microenvironments
#17
Jirui Wen, Yali Miao, Shichao Wang, Ruijie Tong, Zhiwei Zhao, Jiang Wu
Although calcification in the gynecologic tumor microenvironments is a common phenomenon, doctors and researchers still disregard or ignore the issue. In fact, this change in the gynecologic tumor microenvironments is clinically significant and a number of studies have reported an association between calcification and gynecological tumor progression. In ovarian cancer, calcification is predominantly psammomatous and largely occurs in serous papillary ovarian tumors. In addition, calcification in ovarian cancer correlated with lower histologic grade and may indicate a poorer survival rate...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29299638/prediction-of-neutrophil-reduction-using-plasma-paclitaxel-concentration-after-administration-in-patients-with-uterine-ovarian-or-cervical-cancers-in-an-outpatient-clinic
#18
Motoaki Ishikawa, Michiyasu Kawai, Toshio Maeda, Yoshiyuki Kagawa
PURPOSE: Plasma paclitaxel (PTX) concentration 24 h or later after PTX administration may predict myelosuppression. Here, we explored predictive markers for neutropenia induced by intravenous administration of PTX in an outpatient clinic. METHODS: Thirty women suffering from uterine, ovarian or cervical cancer were enrolled in this study. PTX (mean dose: 167 mg/m2 ) was intravenously infused and followed by carboplatin. Plasma samples were obtained 4 h after PTX administration...
February 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29290193/spectrum-of-gynecological-malignancies-at-jamshoro
#19
Naheed Parveen, Raheel Sikander, Majida, Shaheen
OBJECTIVE: To describe the frequency and spectrum of different types of gynecological malignancies. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences, Jamshoro, from January 2014 to December 2015. METHODOLOGY: All patients with gynecological malignancies, admitted at the study place, whether previously diagnosed or need to establish the diagnosis on the basis of EUA, biopsy, staging and for surgery during the study period were included...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29284020/health-status-by-gender-hair-color-and-eye-color-red-haired-women-are-the-most-divergent
#20
Peter Frost, Karel Kleisner, Jaroslav Flegr
Red hair is associated in women with pain sensitivity. This medical condition, and perhaps others, seems facilitated by the combination of being red-haired and female. We tested this hypothesis by questioning a large sample of Czech and Slovak respondents about the natural redness and darkness of their hair, their natural eye color, their physical and mental health (24 categories), and other personal attributes (height, weight, number of children, lifelong number of sexual partners, frequency of smoking). Red-haired women did worse than other women in ten health categories and better in only three, being particularly prone to colorectal, cervical, uterine, and ovarian cancer...
2017: PloS One
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