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B Maher, R O'Neill, A Faruqui, C Bergin, M Horgan, D Bennett, C M P O'Tuathaigh
BACKGROUND: Doctors' continuing professional development (CPD) training needs are known to be strongly influenced by national and local contextual characteristics. Given the changing national demographic profile and government-mandated changes to primary care health care provision, this study aimed to investigate Irish General Practitioners' (GPs) perceptions of, and preferences for, current and future CPD programmes. METHODS: A cross-sectional questionnaire, using closed- and open-ended questions, was administered to Irish GPs, focusing on training needs analysis; CPD course content; preferred format and the learning environment...
June 14, 2017: Education for Primary Care
Penny Farrell, Anne Marie Thow, Seye Abimbola, Neha Faruqui, Joel Negin
While food insecurity is a well-known cause of under-nutrition and stunting, in recent decades it has also been linked with obesity. Understanding and thus minimising the risk factors for obesity in low- and middle-income country contexts, which often lack the health system capacity to treat the consequent obesity-related illnesses, is crucial. This study adopted realist review methodology because it enabled us to analyse and organise the evidence from low- and middle-income countries into a coherent scheme...
May 24, 2017: Health Promotion International
Alice Pyne, Marc-Philipp Pfeil, Isabel Bennett, Jascindra Ravi, Patrizia Iavicoli, Baptiste Lamarre, Anita Roethke, Santanu Ray, Haibo Jiang, Angelo Bella, Bernd Reisinger, Daniel Yin, Benjamin Little, Juan C Muñoz-García, Eleonora Cerasoli, Peter J Judge, Nilofar Faruqui, Luigi Calzolai, Andre Henrion, Glenn J Martyna, Chris R M Grovenor, Jason Crain, Bart W Hoogenboom, Anthony Watts, Maxim G Ryadnov
The spread of bacterial resistance to traditional antibiotics continues to stimulate the search for alternative antimicrobial strategies. All forms of life, from bacteria to humans, are postulated to rely on a fundamental host defense mechanism, which exploits the formation of open pores in microbial phospholipid bilayers. Here we predict that transmembrane poration is not necessary for antimicrobial activity and reveal a distinct poration mechanism that targets the outer leaflet of phospholipid bilayers. Using a combination of molecular-scale and real-time imaging, spectroscopy and spectrometry approaches, we introduce a structural motif with a universal insertion mode in reconstituted membranes and live bacteria...
February 1, 2017: Chemical Science
P J Devereaux, Bruce M Biccard, Alben Sigamani, Denis Xavier, Matthew T V Chan, Sadeesh K Srinathan, Michael Walsh, Valsa Abraham, Rupert Pearse, C Y Wang, Daniel I Sessler, Andrea Kurz, Wojciech Szczeklik, Otavio Berwanger, Juan Carlos Villar, German Malaga, Amit X Garg, Clara K Chow, Gareth Ackland, Ameen Patel, Flavia Kessler Borges, Emilie P Belley-Cote, Emmanuelle Duceppe, Jessica Spence, Vikas Tandon, Colin Williams, Robert J Sapsford, Carisi A Polanczyk, Maria Tiboni, Pablo Alonso-Coello, Atiya Faruqui, Diane Heels-Ansdell, Andre Lamy, Richard Whitlock, Yannick LeManach, Pavel S Roshanov, Michael McGillion, Peter Kavsak, Matthew J McQueen, Lehana Thabane, Reitze N Rodseth, Giovanna A Lurati Buse, Mohit Bhandari, Ignacia Garutti, Michael J Jacka, Holger J Schünemann, Olga Lucía Cortes, Pierre Coriat, Nazari Dvirnik, Fernando Botto, Shirley Pettit, Allan S Jaffe, Gordon H Guyatt
Importance: Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Objective: To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). Design, Setting, and Participants: Prospective cohort study of patients aged 45 years or older who underwent inpatient noncardiac surgery and had a postoperative hsTnT measurement...
April 25, 2017: JAMA: the Journal of the American Medical Association
R Tabassum, A R Mia, K M Reza-Ul-Haq, M Yesmin, J M Faruqui
C-reactive protein (CRP) is a sensitive physiological biomarker of sub-clinical inflammation associated with hyperglycemia, insulin resistance and type 2 diabetic patients. A cross sectional study of 120 subjects attending outpatient department of Mymensingh Medical College, Mymensingh was done with an aim to evaluate serum C-reactive protein in type 2 diabetic patients and compare with age matched non-diabetic persons from July 2014 to June 2015. Of the total cases, 60 were Type 2 diabetic patients and 60 were apparently healthy non-diabetic persons recruited for the study...
January 2017: Mymensingh Medical Journal: MMJ
Hussam Uddin Soomro, Imran Jalbani, Nuzhat Faruqui
Foreign body in bladder is relatively uncommon condition with variable presentations. Literature is limited to case reports and small series from region. Therefore, we planned this study to review our experience regarding intravesical foreign body. This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised 14 patients having intravesical foreign bodies from March 1989 to March 2013. Demographics, presentation, mode of insertion, type of foreign body and management were noted...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Lydia Zajiczek, Michael Shaw, Nilofar Faruqui, Angelo Bella, Vijay M Pawar, Mandayam A Srinivasan, Maxim G Ryadnov
Extracellular protein matrices provide a rigidity interface exhibiting nano-mechanical cues that guide cell growth and proliferation. Cells sense such cues using actin-rich filopodia extensions which encourage favourable cell-matrix contacts to recruit more actin-mediated local forces into forming stable focal adhesions. A challenge remains in identifying and measuring these local cellular forces and in establishing empirical relationships between them, cell adhesion and filopodia formation. Here we investigate such relationships using a micromanipulation system designed to operate at the time scale of focal contact dynamics, with the sample frequency of a force probe being 0...
October 13, 2016: Nanoscale
Kanhaiya L Poddar, Dhruv K Modi, Siddharth Wayangankar, Badal Thakkar, Amar Krishnaswamy, Meera Kumari, Hazem Bdair, Karan Sud, Akhil Parashar, Mohammad Qasim Raza, Raquib Faruqui, Shikhar Agarwal, Kinjal Banerjee, E Murat Tuzcu, Samir R Kapadia
Data are limited about the prevalence trends of risk factors, lesion morphology, and clinical outcomes of coronary artery disease in patients, aged ≤45 years, undergoing percutaneous coronary intervention (PCI), between the bare-metal stent (BMS; 1994 to 2002) and drug-eluting stent (DES; 2003 to 2012) eras. From the PCI database at the Cleveland Clinic, we identified 1,640 patients aged ≤45 years and without a history of coronary artery bypass grafting who underwent PCI from 1994 to 2012. There were 883 patients in the BMS era cohort with a mean follow-up period of 13...
October 1, 2016: American Journal of Cardiology
Abdullah Foad, Sami Faruqui
BACKGROUND: Absence of the long head of the biceps brachii (LHB) tendon is rare with an unknown incidence. It can occur bilaterally in patients with or without associated congenital anomalies. Diagnostic difficulty exists with both magnetic resonance imaging and physical examination. METHODS/RESULTS: We present the case of a 24-year-old female with a three year history of progressive right shoulder pain and instability with negative magnetic resonance arthrogram who was subsequently found to have absence of the LHB tendon...
2016: Iowa Orthopaedic Journal
A Martiniuk, J Jacob, N Faruqui, W Yu
BACKGROUND: This study sought to better understand parent, grandparent and clinician views of prevention, treatment and costs of plagiocephaly. METHODS: A qualitative study was conducted using focus groups and semi-structured interviews. A grounded theory approach was taken to build theories from the qualitative data collected. A subjectivist epistemological orientation was taken under the paradigm of positivism. RESULTS: Ninety-one parents, 6 grandparents and 24 clinicians were recruited from the community as well as primary and tertiary care clinics...
August 9, 2016: Child: Care, Health and Development
Saima Riaz, Muhammad Khalid Nawaz, Zia S Faruqui, Syed Ather Saeed Kazmi, Asif Loya, Humayun Bashir
OBJECTIVE: Detection of primary tumor site in patients with carcinoma of unknown primary (CUP) syndrome has always been a diagnostic dilemma, necessitating extensive workup. Early detection of primary tumor site coupled with specific therapy improves prognosis. The low detection rate of the primary tumor site can be attributed to the biological behavior or the small size of the primary tumor to be detected by conventional imaging. The objective of this study was to evaluate the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) in detecting CUP...
February 5, 2016: Molecular Imaging and Radionuclide Therapy
Elizabeth K Parker, Sahrish S Faruquie, Gail Anderson, Linette Gomes, Andrew Kennedy, Christine M Wearne, Michael R Kohn, Simon D Clarke
Introduction. This study examines weight gain and assesses complications associated with refeeding hospitalised adolescents with restrictive eating disorders (EDs) prescribed initial calories above current recommendations. Methods. Patients admitted to an adolescent ED structured "rapid refeeding" program for >48 hours and receiving ≥2400 kcal/day were included in a 3-year retrospective chart review. Results. The mean (SD) age of the 162 adolescents was 16.7 years (0.9), admission % median BMI was 80...
2016: Journal of Nutrition and Metabolism
Sami Faruqui, Mohammad A Kotob, Courtney C Hanna, Abdullah Foad
PURPOSE: The purpose of this study was to evaluate clinical outcomes and complications in a series of patients who underwent the modified Norwegian method (MNM) of biceps tenodesis by a single shoulder surgeon. METHODS: A retrospective review of charts from all patients who underwent the modified Norwegian method of biceps tenodesis by the senior author during a 5-year period between 2008 and 2013 was performed. After all patients were identified, informed consent was obtained and DASH and ASES surveys were administered...
May 3, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Sahrish Sonia Faruquie, Elizabeth Kumiko Parker, Peter Talbot
Objective The aims of the present study, in home enteral nutrition (HEN) patients, were to assess patient satisfaction with the service and quality of life (QOL) scores, and to compare QOL scores in HEN patients with general Australian population values.Methods Self-administered voluntary questionnaires for the present cross-sectional study were mailed out to 322 eligible participants registered with HEN for >5 months. The questionnaires used included a patient satisfaction survey and a validated QOL questionnaire...
March 3, 2016: Australian Health Review: a Publication of the Australian Hospital Association
Zeina M Saleh, Sami Faruqui, Abdullah Foad
OBJECTIVE: Adhesive capsulitis has been suggested as an adverse effect of vaccine administration into the shoulder area. The purpose of this case series is to report 3 cases of acute onset of adhesive capsulitis following pneumococcal and influenza vaccines. CLINICAL FEATURES: Patients reported painful shoulder and limited motion following routine vaccination. After clinical examination, a diagnosis of adhesive capsulitis was noted. INTERVENTION AND OUTCOME: All 3 patients were treated conservatively with physical therapy (active ranges of motion and active-assisted motion), nonsteroidal anti-inflammatory drugs, and activity modification with eventual resolution of symptoms...
December 2015: Journal of Chiropractic Medicine
Yulia Zyrianova, Lauren Alexander, Rafey Faruqui
OBJECTIVE: The purpose of this study was to systematically review the literature relating to the neuropsychiatric symptoms at presentation and outcome of childhood brain tumours. METHODS: Seven online databases pertaining to the neuropsychiatric presentation and outcomes of childhood CNS tumours were searched and PRISMA guidelines were followed. Temporal limits were not applied to the searches. RESULTS: There were 1879 relevant search results in total...
2016: Brain Injury: [BI]
Atif Javed, Aziz Abdullah, Nuzhat Faruqui, Sher Shah Syed, Abdul Jabbar Pirzada
OBJECTIVE: To evaluate various prognostic factors which determine outcome after surgical repair of vesicovaginal fistula. METHODS: The retrospective study was conducted at Koohi Goth Fistula Hospital, Karachi, and comprised data related to patients having undergone vesicovaginal fistula repair from January 2007 to June 2012. Multivariate analysis of the record was done using SPSS 19 software determining odds ratio with 95% confidence interval. RESULTS: Record of 640 patients were analysed with an overall success in 558(87...
September 2015: JPMA. the Journal of the Pakistan Medical Association
Mangala Rao, Denis Xavier, Padmini Devi, Alben Sigamani, Atiya Faruqui, Rajeev Gupta, Prafulla Kerkar, Rajendra Kumar Jain, Rajnish Joshi, N Chidambaram, Daya Sagar Rao, S Thanikachalam, S S Iyengar, Kiron Verghese, V Mohan, Prem Pais
AIM: To conduct a systematic review on the prevalence, risk factors, treatments and outcomes of Coronary Artery Disease (CAD) in Indians. METHODS AND RESULTS: We conducted a systematic review of studies in Indians with CAD from Jan 1969 to Oct 2012. Initial search yielded 3885 studies and after review 288 observational studies were included. The prevalence of CAD in urban areas was 2.5%-12.6% and in rural areas, 1.4%-4.6%. The prevalence of risk factors was: smoking (8...
July 2015: Indian Heart Journal
Sahrish Sonia Faruquie, Elizabeth Kumiko Parker, Peter Talbot
OBJECTIVE: This cross-sectional study investigates the home enteral nutrition (HEN) services of public principal referral hospitals in NSW, Australia, comparing their services to best practice guidelines for HEN. METHODS: HEN service processes were investigated using an online questionnaire and telephone interview with the dietitian primarily working with HEN at each hospital. RESULTS: Participating hospitals reported a total of approximately 3200 HEN patients, 76% required oral nutrition support...
February 2016: Australian Health Review: a Publication of the Australian Hospital Association
Musa Basseer Sami, Rafey Faruqui
OBJECTIVE: Traumatic brain injury and stroke are among the leading causes of neurological disability worldwide. Although dopaminergic agents have long been associated with improvement of neuropsychiatric outcomes, to date much of the evidence to date has been in case reports and case series or open label trials. METHODS: We undertook a systematic review of double-blinded randomised controlled trials (RCT) to determine the effect of dopaminergic agents on pre-defined outcomes of (a) apathy; (b) psychomotor retardation; (c) behavioural management and (d) cognitive function...
December 2015: Acta Neuropsychiatrica
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