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https://www.readbyqxmd.com/read/28329800/characterizing-readiness-for-advance-care-planning-from-the-perspective-of-residents-families-and-clinicians-an-interpretive-descriptive-study-in-supportive-living
#1
Marta Shaw, Jennifer Hewson, David B Hogan, Shelley Raffin Bouchal, Jessica Simon
Background and Objectives: Advance care planning (ACP) involves reflection on health care preferences and communication of the person's wishes in case of future incapacity. ACP is particularly pertinent in supportive living (SL) as residents are at high risk of cognitive decline and changes in health status, but the readiness of residents, families, and health care practitioners to engage in ACP discussions is not known. The purpose of this study was to explore the readiness among these stakeholders and the factors that influence the degree of readiness...
February 18, 2017: Gerontologist
https://www.readbyqxmd.com/read/28328704/distant-migration-after-clandestine-silicone-injections-how-far-is-too-far
#2
Paul D Durand, Sara R Hogan, Gregory A Lamaris, Ali Totonchi
No abstract text is available yet for this article.
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28325866/temporal-and-demographic-trends-in-glomerular-disease-epidemiology-in-the-southeastern-united-states-1986-2015
#3
Michelle M O'Shaughnessy, Susan L Hogan, Caroline J Poulton, Ronald J Falk, Harsharan K Singh, Volker Nickeleit, J Charles Jennette
BACKGROUND AND OBJECTIVES: Large-scale, contemporary studies exploring glomerular disease epidemiology in the United States are lacking. We aimed to determine 30-year temporal and demographic trends in renal biopsy glomerular disease diagnosis frequencies in the southeastern United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this cross-sectional, observational study, we identified all patients with a native kidney biopsy specimen showing one of 18 widely recognized glomerular disease diagnoses referred to the University of North Carolina Chapel Hill Division of Nephropathology between 1986 and 2015...
March 21, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28325763/pseudomonas-aeruginosa-alginate-overproduction-promotes-coexistence-with-staphylococcus-aureus-in-a-model-of-cystic-fibrosis-respiratory-infection
#4
Dominique H Limoli, Gregory B Whitfield, Tomoe Kitao, Melissa L Ivey, Michael R Davis, Nora Grahl, Deborah A Hogan, Laurence G Rahme, P Lynne Howell, George A O'Toole, Joanna B Goldberg
While complex intra- and interspecies microbial community dynamics are apparent during chronic infections and likely alter patient health outcomes, our understanding of these interactions is currently limited. For example, Pseudomonas aeruginosa and Staphylococcus aureus are often found to coinfect the lungs of patients with cystic fibrosis (CF), yet these organisms compete under laboratory conditions. Recent observations that coinfection correlates with decreased health outcomes necessitate we develop a greater understanding of these interbacterial interactions...
March 21, 2017: MBio
https://www.readbyqxmd.com/read/28325112/potential-of-personal-health-record-portals-in-the-care-of-individuals-with-spinal-cord-injuries-and-disorders-provider-perspectives
#5
Jennifer N Hill, Bridget M Smith, Frances M Weaver, Kim M Nazi, Florian P Thomas, Barry Goldstein, Timothy P Hogan
CONTEXT/OBJECTIVE: Although personal health record (PHR) portals are designed for patients, healthcare providers are a key influence in how patients use their features and realize benefits from them. A few studies have examined provider attitudes toward PHR portals, but none have focused on those who care for individuals with spinal cord injuries and disorders (SCI/D). We characterize SCI/D provider perspectives of PHR portals, including perceived advantages and disadvantages of PHR portal use in SCI/D care...
March 21, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28306339/working-memory-in-school-age-children-with-and-without-a-persistent-speech-sound-disorder
#6
Kelly Farquharson, Tiffany P Hogan, John E Bernthal
PURPOSE: The aim of this study was to explore the role of working memory processes as a possible cognitive underpinning of persistent speech sound disorders (SSD). METHOD: Forty school-aged children were enrolled; 20 children with persistent SSD (P-SSD) and 20 typically developing children. Children participated in three working memory tasks - one to target each of the components in Baddeley's working memory model: phonological loop, visual spatial sketchpad and central executive...
March 17, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28302438/antipsychotic-use-and-hospitalization-among-older-assisted-living-residents-does-risk-vary-by-frailty-status
#7
Kathryn J Stock, David B Hogan, Kate Lapane, Joseph E Amuah, Suzanne L Tyas, Susan E Bronskill, Andrew M Morris, Chaim M Bell, Lianne Jeffs, Colleen J Maxwell
OBJECTIVE: To examine associations between baseline frailty measures, antipsychotic use, and hospitalization over 1 year and whether hospitalization risk associated with antipsychotic use varies by frailty level. METHODS: In this prospective cohort study of 1,066 residents (mean age: 85 years; 77% women) from the Alberta Continuing Care Epidemiological Studies, trained research nurses conducted comprehensive resident assessments at baseline (2006-2007) for sociodemographic characteristics, health conditions, frailty status, behavioral problems, and all medications consumed during the past 3 days...
February 16, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28292845/lung-organoids-current-uses-and-future-promise
#8
REVIEW
Christina E Barkauskas, Mei-I Chung, Bryan Fioret, Xia Gao, Hiroaki Katsura, Brigid L M Hogan
Lungs are composed of a system of highly branched tubes that bring air into the alveoli, where gas exchange takes place. The proximal and distal regions of the lung contain epithelial cells specialized for different functions: basal, secretory and ciliated cells in the conducting airways and type II and type I cells lining the alveoli. Basal, secretory and type II cells can be grown in three-dimensional culture, with or without supporting stromal cells, and under these conditions they give rise to self-organizing structures known as organoids...
March 15, 2017: Development
https://www.readbyqxmd.com/read/28292541/mycobacterial-musculoskeletal-infections
#9
REVIEW
John I Hogan, Rocío M Hurtado, Sandra B Nelson
Although less common as causes of musculoskeletal infection than pyogenic bacteria, both Mycobacterium tuberculosis and nontuberculous mycobacteria can infect bones and joints. Although tuberculous arthritis and osteomyelitis have been recognized for millennia, infections caused by nontuberculous mycobacteria are being identified more often, likely because of a more susceptible host population and improvements in diagnostic capabilities. Despite advances in modern medicine, mycobacterial infections of the musculoskeletal system remain particularly challenging to diagnose and manage...
March 11, 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28292268/social-inclusion-for-children-with-hearing-loss-in-listening-and-spoken-language-early-intervention-an-exploratory-study
#10
Gabriella Constantinescu-Sharpe, Rebecca L Phillips, Aleisha Davis, Dimity Dornan, Anthony Hogan
BACKGROUND: Social inclusion is a common focus of listening and spoken language (LSL) early intervention for children with hearing loss. This exploratory study compared the social inclusion of young children with hearing loss educated using a listening and spoken language approach with population data. METHODS: A framework for understanding the scope of social inclusion is presented in the Background. This framework guided the use of a shortened, modified version of the Longitudinal Study of Australian Children (LSAC) to measure two of the five facets of social inclusion ('education' and 'interacting with society and fulfilling social goals')...
March 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28289719/type-i-interferons-regulate-susceptibility-to-inflammation-induced-preterm-birth
#11
Monica Cappelletti, Pietro Presicce, Matthew J Lawson, Vandana Chaturvedi, Traci E Stankiewicz, Simone Vanoni, Isaac T W Harley, Jaclyn W McAlees, Daniel A Giles, Maria E Moreno-Fernandez, Cesar M Rueda, Paranth Senthamaraikannan, Xiaofei Sun, Rebekah Karns, Kasper Hoebe, Edith M Janssen, Christopher L Karp, David A Hildeman, Simon P Hogan, Suhas G Kallapur, Claire A Chougnet, Sing Sing Way, Senad Divanovic
Preterm birth (PTB) is a leading worldwide cause of morbidity and mortality in infants. Maternal inflammation induced by microbial infection is a critical predisposing factor for PTB. However, biological processes associated with competency of pathogens, including viruses, to induce PTB or sensitize for secondary bacterial infection-driven PTB are unknown. We show that pathogen/pathogen-associated molecular pattern-driven activation of type I IFN/IFN receptor (IFNAR) was sufficient to prime for systemic and uterine proinflammatory chemokine and cytokine production and induction of PTB...
March 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28283662/exhaustion-associated-regulatory-regions-in-cd8-tumor-infiltrating-t-cells
#12
Giuliana P Mognol, Roberto Spreafico, Victor Wong, James P Scott-Browne, Susan Togher, Alexander Hoffmann, Patrick G Hogan, Anjana Rao, Sara Trifari
T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (TILs) that recognize a model tumor antigen and have features of both activation and functional exhaustion. By filtering out accessible regions observed in bystander, nonexhausted TILs and in acutely restimulated CD8(+) T cells, we define a pattern of chromatin accessibility specific for T-cell exhaustion, characterized by enrichment for consensus binding motifs for Nr4a and NFAT transcription factors...
March 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28282024/memory-cd4-t-cell-subsets-are-kinetically-heterogeneous-and-replenished-from-naive-t-cells-at-high-levels
#13
Graeme Gossel, Thea Hogan, Daniel Cownden, Benedict Seddon, Andrew J Yates
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to maintenance of memory compartments. Here, we characterise the kinetics and structure of murine CD4 T cell memory subsets by measuring the rates of influx of new cells and using detailed timecourses of DNA labelling that also distinguish the behaviour of recently divided and quiescent cells...
March 10, 2017: ELife
https://www.readbyqxmd.com/read/28281129/autism-spectrum-disorder-symptoms-in-infants-with-fragile-x-syndrome-a-prospective-case-series
#14
Abigail L Hogan, Kelly E Caravella, Jordan Ezell, Lisa Rague, Kimberly Hills, Jane E Roberts
No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD...
March 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28280553/the-confusion-effect-when-attacking-simulated-three-dimensional-starling-flocks
#15
Benedict G Hogan, Hanno Hildenbrandt, Nicholas E Scott-Samuel, Innes C Cuthill, Charlotte K Hemelrijk
The confusion effect describes the phenomenon of decreasing predator attack success with increasing prey group size. However, there is a paucity of research into the influence of this effect in coherent groups, such as flocks of European starlings (Sturnus vulgaris). Here, for the first time, we use a computer game style experiment to investigate the confusion effect in three dimensions. To date, computerized studies on the confusion effect have used two-dimensional simulations with simplistic prey movement and dynamics...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28279643/follistatin-gene-therapy-for-sporadic-inclusion-body-myositis-improves-functional-outcomes
#16
Jerry R Mendell, Zarife Sahenk, Samiah Al-Zaidy, Louise R Rodino-Klapac, Linda P Lowes, Lindsay N Alfano, Katherine Berry, Natalie Miller, Mehmet Yalvac, Igor Dvorchik, Melissa Moore-Clingenpeel, Kevin M Flanigan, Kathleen Church, Kim Shontz, Choumpree Curry, Sarah Lewis, Markus McColly, Mark J Hogan, Brian K Kaspar
Sporadic inclusion body myositis, a variant of inflammatory myopathy, has features distinct from polymyositis/dermatomyositis. The disease affects men more than women, most commonly after age 50. Clinical features include weakness of the quadriceps, finger flexors, ankle dorsiflexors, and dysphagia. The distribution of weakness is similar to Becker muscular dystrophy, where we previously reported improvement following intramuscular injection of an isoform of follistatin (FS344) by AAV1. For this clinical trial, rAAV1...
March 6, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28277760/effectiveness-of-ways-to-improve-detection-and-rescue-of-deteriorating-patients
#17
Helen Hogan, Catherine Carver, Rebecca Zipfel, Andrew Hutchings, John Welch, David Harrison, Nick Black
A number of interventions has been introduced to improve recognition of and response to deterioration, but evidence for improved outcomes is mixed. Future evaluations need better articulation of intervention components and outcomes, longer run-in times and consideration of the interplay between concurrent interventions.
March 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28273407/use-of-the-parihs-framework-for-retrospective-and-prospective-implementation-evaluations
#18
Jennifer N Hill, Marylou Guihan, Timothy P Hogan, Bridget M Smith, Sherri L LaVela, Frances M Weaver, Henry D Anaya, Charlesnika T Evans
BACKGROUND: The Promoting Action on Research Implementation in Health Services (PARIHS) framework has been used by implementation researchers to assess factors impacting implementation and to use that information to identify optimal interventions and implementation strategies. In this paper, two studies are presented demonstrating the utility of PARIHS as a tool for retrospective and prospective evaluation of implementation in the health care setting. STUDY DESIGN: Descriptive case study...
March 8, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28272143/malignant-hypercompliance
#19
Kirk Hogan
No abstract text is available yet for this article.
March 8, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28267802/multimorbidity-and-healthcare-utilization-among-home-care-clients-with-dementia-in-ontario-canada-a-retrospective-analysis-of-a-population-based-cohort
#20
Luke Mondor, Colleen J Maxwell, David B Hogan, Susan E Bronskill, Andrea Gruneir, Natasha E Lane, Walter P Wodchis
BACKGROUND: For community-dwelling older persons with dementia, the presence of multimorbidity can create complex clinical challenges for both individuals and their physicians, and can contribute to poor outcomes. We quantified the associations between level of multimorbidity (chronic disease burden) and risk of hospitalization and risk of emergency department (ED) visit in a home care cohort with dementia and explored the role of continuity of physician care (COC) in modifying these relationships...
March 2017: PLoS Medicine
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