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https://www.readbyqxmd.com/read/28921820/systematic-review-and-network-meta-analysis-on-the-relative-efficacy-of-osteoporotic-medications-men-with-prostate-cancer-on-continuous-androgen-deprivation-therapy%C3%A2-to-reduce-risk-of-fragility-fractures
#1
REVIEW
Yeesha Poon, Petros Pechlivanoglou, Shabbir M H Alibhai, David Naimark, Jeffrey S Hoch, Emmanuel Papadimitropoulos, Mary-Ellen Hogan, Murray Krahn
BACKGROUND: Androgen deprivation therapy (ADT) is an effective treatment for men with advanced prostate cancer, but loss of bone mineral density (BMD) is a major risk factor for fractures. This analysis evaluated the relative effectiveness of osteoporosis treatments using BMD as a surrogate endpoint for fragility fractures in men on continuous ADT. METHOD: We included randomized controlled trials studying bisphosphonates, denosumab, toremifene, and raloxifene in patients with non-metastatic prostate cancer on ADT for review...
September 18, 2017: BJU International
https://www.readbyqxmd.com/read/28921340/nephrotic-range-proteinuria-and-brown-urine-in-an-8-year-old-girl-answers
#2
Emilie Saucier, Julien Hogan, Michel Peuchmaur, Georges Deschênes, Andre Baruchel, Vasiliki Karava
No abstract text is available yet for this article.
September 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28921016/nephrotic-range-proteinuria-and-brown-urine-in-an-8-year-old-girl-questions
#3
Emilie Saucier, Julien Hogan, Michel Peuchmaur, Georges Deschênes, Andre Baruchel, Vasiliki Karava
No abstract text is available yet for this article.
September 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28918956/healthcare-utilization-and-expenditures-for-united-states-medicare-beneficiaries-with-systemic-vasculitis
#4
Carolyn T Thorpe, Joshua M Thorpe, Tao Jiang, Dylan Atkinson, Yihuang Kang, Loren J Schleiden, Delesha M Carpenter, Julie Anne G McGregor, Susan L Hogan
OBJECTIVE: The Medicare federal insurance program is the most common United States insurer of patients with systemic vasculitis (SV). We compared healthcare utilization and expenditures for Medicare beneficiaries with versus without SV. METHODS: This national, retrospective study used 2010 claims and enrollment data for a 100% cohort of Medicare Part A and B beneficiaries with ≥1 claim including a diagnosis for a form of SV (n = 176,498), and a randomly selected group of non-SV beneficiaries (n = 46,561)...
August 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28918946/cooperative-behavior-emerges-among-drosophila-larvae
#5
Mark Dombrovski, Leanne Poussard, Kamilia Moalem, Lucia Kmecova, Nic Hogan, Elisabeth Schott, Andrea Vaccari, Scott Acton, Barry Condron
Spectacular examples of cooperative behavior emerge among a variety of animals and may serve critical roles in fitness [1, 2]. However, the rules governing such behavior have been difficult to elucidate [2]. Drosophila larvae are known to socially aggregate [3, 4] and use vision, mechanosensation, and gustation to recognize each other [5-8]. We describe here a model experimental system of cooperative behavior involving Drosophila larvae. While foraging in liquid food, larvae are observed to align themselves and coordinate their movements in order to drag a common air cavity and dig deeper...
September 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#6
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
September 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28916496/designer-bacteria-as-intratumoural-enzyme-biofactories
#7
Panos Lehouritis, Glenn Hogan, Mark Tangney
Bacterial-directed enzyme prodrug therapy (BDEPT) is an emerging form of treatment for cancer. It is a biphasic variant of gene therapy in which a bacterium, armed with an enzyme that can convert an inert prodrug into a cytotoxic compound, induces tumour cell death following tumour-specific prodrug activation. BDEPT combines the innate ability of bacteria to selectively proliferate in tumours, with the capacity of prodrugs to undergo contained, compartmentalised conversion into active metabolites in vivo. Although BDEPT has undergone clinical testing, it has received limited clinical exposure, and has yet to achieve regulatory approval...
September 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28914532/aggregation-induced-electrochemiluminescence-of-platinum-ii-complexes
#8
Serena Carrara, Alessandro Aliprandi, Conor F Hogan, Luisa De Cola
We report the electrochemiluminescence properties of square-planar Pt(II) complexes which result from the formation of supramolecular nanostructures. We define this new phenomenon as Aggregation-Induced Electrochemiluminescence (AIECL). In this system, self-assembly changes the HOMO and LUMO energies, making their population accessible via ECL pathways and leading to the generation of the luminescent excited state. Significantly, the emission from the self-assembled system is the first example of Electro-chemiluminescence (ECL) of Pt(II) complexes in aque-ous solution having higher efficiency than the standard, Ru(bpy)32+...
September 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28914343/image-guided-percutaneous-removal-of-ballistic-foreign-bodies-secondary-to-air-gun-injuries
#9
Jacob L Rothermund, Andrew J Rabe, Nicholas A Zumberge, James W Murakami, Patrick S Warren, Mark J Hogan
BACKGROUND: Ballistic injuries with retained foreign bodies from air guns is a relatively common problem, particularly in children and adolescents. If not removed in a timely fashion, the foreign bodies can result in complications, including pain and infection. Diagnostic methods to identify the presence of the foreign body run the entire gamut of radiology, particularly radiography, ultrasound (US) and computed tomography (CT). Removal of the foreign bodies can be performed by primary care, emergency, surgical, and radiologic clinicians, with or without imaging guidance...
September 15, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28906236/ranked-performance-of-canada-s-health-system-on-the-international-stage-a-scoping-review
#10
Said Ahmad Maisam Najafizada, Thushara Sivanandan, Kelly Hogan, Deborah Cohen, Jean Harvey
INTRODUCTION: Since the release of the World Health Report in 2000, health system performance ranking studies have garnered significant health policy attention. However, this literature has produced variable results. The objective of this study was to synthesize the research and analyze the ranked performance of Canada's health system on the international stage. METHOD: We conducted a scoping review exploring Canada's place in ranked health system performance among its peer Organisation for Economic Co-operation and Development countries...
August 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28906023/immunophenotypic-and-molecular-comparison-between-allogeneic-and-autologous-graft-vs-host-disease-of-the-skin-a-retrospective-study-using-immunohistochemical-and-proteomics-methods
#11
Julia S Lehman, Shahrukh K Hashmi, Hillard M Lazarus, Rokea A El-Azhary, Lawrence E Gibson, William J Hogan, Mark R Litzow, Mrinal S Patnaik, Francis Buadi, Martha Q Lacy, Surendra Dasari, Patrick Vanderboom, Alexander Meves
No abstract text is available yet for this article.
September 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28900908/the-stim-orai-pathway-orai-the-pore-forming-subunit-of-the-crac-channel
#12
Aparna Gudlur, Patrick G Hogan
This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca(2+) entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28885498/patient-and-kidney-allograft-survival-in-recipients-with-end-stage-renal-disease-from-amyloidosis
#13
Deirdre Sawinski, Mary Ann Lim, Jordana C Cohen, Jayme E Locke, Brendan Weiss, Jonathan J Hogan, Laura M Dember
BACKGROUND: Outcomes following kidney transplantation for patients with amyloidosis-associated end-stage renal disease (ESRD) have not been well characterized. METHODS: We performed a retrospective propensity score matched cohort study with Cox proportional hazards modeling using data from the United Network of Organ Sharing including patients transplanted from 1987 to 2015 (N=310 629). RESULTS: Amyloidosis patients (N=576) had higher rates of death (HR 1...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28879833/prevalence-of-mild-behavioral-impairment-in-mild-cognitive-impairment-and-subjective-cognitive-decline-and-its-association-with-caregiver-burden
#14
Faisal Sheikh, Zahinoor Ismail, Moyra E Mortby, Philip Barber, Alicja Cieslak, Karyn Fischer, Robert Granger, David B Hogan, Aaron Mackie, Colleen J Maxwell, Bijoy Menon, Patricia Mueller, David Patry, Dawn Pearson, Jeremy Quickfall, Tolulope Sajobi, Eric Tse, Meng Wang, Eric E Smith
BACKGROUND: Mild behavioral impairment (MBI) describes later life acquired, sustained neuropsychiatric symptoms (NPS) in cognitively normal individuals or those with mild cognitive impairment (MCI), as an at-risk state for incident cognitive decline and dementia. We developed an operational definition of MBI and tested whether the presence of MBI was related to caregiver burden in patients with subjective cognitive decline (SCD) or MCI assessed at a memory clinic. METHODS: MBI was assessed in 282 consecutive memory clinic patients with SCD (n = 119) or MCI (n = 163) in accordance with the International Society to Advance Alzheimer's Research and Treatment - Alzheimer's Association (ISTAART-AA) research diagnostic criteria...
September 7, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28872725/dorsal-root-ganglion-field-stimulation-prevents-inflammation-and-joint-damage-in-a-rat-model-of-rheumatoid-arthritis
#15
Bin Pan, Zhiyong Zhang, Dongman Chao, Quinn H Hogan
OBJECTIVES: Electrical stimulation of the dorsal root ganglion (DRG), referred to here as ganglionic field stimulation (GFS), is effective in reducing clinical pain, probably by interrupting transmission of afferent impulse trains on sensory neurons as they pass through the DRG. We therefore tested whether efferent impulse trains conveyed by sensory neurons, which contribute to neurogenic inflammation, may also be interrupted by GFS. MATERIALS AND METHODS: Collagen-induced arthritis, a model of clinical rheumatoid arthritis, was initiated in rats concurrently with the insertion of an electrode for GFS at the fourth lumbar DRG...
September 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28869617/a-phase-1-trial-of-90-y-zevalin-radioimmunotherapy-with-autologous-stem-cell-transplant-for-multiple-myeloma
#16
A Dispenzieri, A D'Souza, M A Gertz, K Laumann, G Wiseman, M Q Lacy, B LaPlant, F Buadi, S R Hayman, S K Kumar, D Dingli, W J Hogan, S M Ansell, D A Gastineau, D J Inwards, I N Micallef, L F Porrata, P B Johnston, M R Litzow, T E Witzig
This phase 1 study (clinical trial NCT00477815) was conducted to determine the maximum tolerated dose (MTD) of yttrium-90 ibritumomab tiuxetan ((90)Y-Zevalin) with high dose melphalan (HDM) therapy in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT). In a 3+3 trial design, 30 patients received rituximab 250 mg/m(2) with indium-111 ibritumomab tiuxetan ((111)In-Zevalin) for dosimetry (day -22); rituximab 250 mg/m(2) with escalating doses of (90)Y-Zevalin (day -14); melphalan 100 mg/m(2) (days -2,-1) followed by ASCT (day 0) and sargramostim (GM-CSF, day 0) until neutrophil engraftment...
September 4, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28861795/strain-typing-of-prion-diseases-using-in-vivo-mouse-models
#17
Aileen Boyle, Kris Hogan, Jean C Manson, Abigail B Diack
Transmissible spongiform encephalopathies (TSE) or prion diseases exhibit strain variation, a phenomenon that has been studied extensively in mouse bioassays. Despite the introduction of many rapid in vitro systems, bioassays remain a key tool in defining prion strains and their ability to transmit disease in vivo. Prion strains can be characterized by a range of phenotypic characteristics such as incubation period, vacuolar pathology, and distribution of the abnormal form of PrP following experimental transmission of the agent into a panel of mice (transgenic or wild type)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28851593/role-of-cystathionine-%C3%AE-lyase-in-hypoxia-induced-changes-in-task-activity-intracellular-ca-2-and-ventilation-in-mice
#18
Jiaju Wang, James O Hogan, Rui Wang, Carl White, Donghee Kim
Cystathionine-γ-lyase (CSE) is a multifunctional enzyme, and hydrogen sulfide (H2S) is one of its products. CSE and H2S have recently been proposed to be critical signaling molecules in hypoxia-induced excitation of carotid body (CB) glomus cells and the chemosensory response. Because the role of H2S in arterial chemoreception is still debated, we further examined the role of CSE by studying the effects of hypoxia on TASK K(+) channel activity, cell depolarization, [Ca(2+)]i and ventilation using CSE(+/+) and CSE(-/-) mice...
August 26, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28844899/integrated-hot-melt-extrusion-injection-molding-continuous-tablet-manufacturing-platform-effects-of-critical-process-parameters-and-formulation-attributes-on-product-robustness-and-dimensional-stability
#19
Parind M Desai, Rachael C Hogan, David Brancazio, Vibha Puri, Keith D Jensen, Jung-Hoon Chun, Allan S Myerson, Bernhardt L Trout
This study provides a framework for robust tablet development using an integrated hot-melt extrusion-injection molding (IM) continuous manufacturing platform. Griseofulvin, maltodextrin, xylitol and lactose were employed as drug, carrier, plasticizer and reinforcing agent respectively. A pre-blended drug-excipient mixture was fed from a loss-in-weight feeder to a twin-screw extruder. The extrudate was subsequently injected directly into the integrated IM unit and molded into tablets. Tablets were stored in different storage conditions up to 20 weeks to monitor physical stability and were evaluated by polarized light microscopy, DSC, SEM, XRD and dissolution analysis...
August 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28844684/characterization-of-n-acetyl-tryptophan-degradation-in-protein-therapeutic-formulations
#20
Kyle L Hogan, Danielle Leiske, Cleo M Salisbury
N-Acetyl-tryptophan (NAT) is used as a stabilizer for preparations of human serum albumin and has more recently been demonstrated to provide oxidative protection for labile Trp residues in monoclonal antibodies. As a component in the formulations of protein therapeutics, NAT is sacrificially degraded; therefore understanding the identity and quantity of NAT degradants potentially formed in these drug products is essential to understanding the potential patient impact of this additive. Here we report a simple reversed phase chromatography approach that allows systematic investigation of NAT degradation in relevant formulations under stressed conditions...
August 24, 2017: Journal of Pharmaceutical Sciences
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