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https://www.readbyqxmd.com/read/29775337/effective-inertial-frame-in-an-atom-interferometric-test-of-the-equivalence-principle
#1
Chris Overstreet, Peter Asenbaum, Tim Kovachy, Remy Notermans, Jason M Hogan, Mark A Kasevich
In an ideal test of the equivalence principle, the test masses fall in a common inertial frame. A real experiment is affected by gravity gradients, which introduce systematic errors by coupling to initial kinematic differences between the test masses. Here we demonstrate a method that reduces the sensitivity of a dual-species atom interferometer to initial kinematics by using a frequency shift of the mirror pulse to create an effective inertial frame for both atomic species. Using this method, we suppress the gravity-gradient-induced dependence of the differential phase on initial kinematic differences by 2 orders of magnitude and precisely measure these differences...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774463/early-cardiovascular-manifestations-in-children-and-adolescents-with-autosomal-dominant-polycystic-kidney-disease-a-single-center-study
#2
Vasiliki Karava, Cherine Benzouid, Julien Hogan, Claire Dossier, André Pierre Denjean, Georges Deschênes
BACKGROUND: This study aims to describe the cardiovascular manifestations in children with autosomal dominant polycystic kidney disease (ADPKD) and detect their relation with kidney disease and type of gene mutation. METHODS: Twenty-one patients (7 to 19 years old) were included. Cardiovascular evaluation involved blood pressure (BP), indexed left ventricular mass (LVMI), pulse wave velocity (PWV), and carotid intima media thickness (cIMT) measurement. Patients were classified according to percentile reference values of these parameters in healthy children...
May 17, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29773646/a-blood-capillary-plexus-derived-population-of-progenitor-cells-contributes-to-genesis-of-the-dermal-lymphatic-vasculature-during-embryonic-development
#3
Cathy Pichol-Thievend, Kelly L Betterman, Xiaolei Liu, Wanshu Ma, Renae Skoczylas, Emmanuelle Lesieur, Frank L Bos, Dorte Schulte, Stefan Schulte-Merker, Benjamin M Hogan, Guillermo Oliver, Natasha L Harvey, Mathias Francois
Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine embryonic lymphatic endothelial cells (LECs) are venous derived has recently been challenged. Here, we show that the embryonic dermal blood capillary plexus constitutes an additional, local source of LECs that contributes to the formation of the dermal lymphatic vascular network. We describe a novel mechanism whereby rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1 -dependent manner to establish discrete LEC clusters...
May 17, 2018: Development
https://www.readbyqxmd.com/read/29773515/integrated-care-programme-for-acute-episodes-in-patients-with-podoconiosis
#4
Sarah C Hogan, L Claire Fuller
No abstract text is available yet for this article.
May 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29769566/antiretroviral-drugs-alter-the-content-of-extracellular-vesicles-from-hiv-1-infected-cells
#5
Catherine DeMarino, Michelle L Pleet, Maria Cowen, Robert A Barclay, Yao Akpamagbo, James Erickson, Nicaise Ndembe, Manhattan Charurat, Jibreel Jumare, Sunday Bwala, Peter Alabi, Max Hogan, Archana Gupta, Nicole Noren Hooten, Michele K Evans, Benjamin Lepene, Weidong Zhou, Massimo Caputi, Fabio Romerio, Walter Royal, Nazira El-Hage, Lance A Liotta, Fatah Kashanchi
To date, the most effective treatment of HIV-1 is a combination antiretroviral therapy (cART), which reduces viral replication and reverses pathology. We investigated the effect of cART (RT and protease inhibitors) on the content of extracellular vesicles (EVs) released from HIV-1-infected cells. We have previously shown that EVs contain non-coding HIV-1 RNA, which can elicit responses in recipient cells. In this manuscript, we show that TAR RNA levels demonstrate little change with the addition of cART treatment in cell lines, primary macrophages, and patient biofluids...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762717/durable-complete-responses-in-some-recurrent-high-grade-glioma-patients-treated-with-toca-511-toca-fc
#6
Timothy F Cloughesy, Joseph Landolfi, Michael A Vogelbaum, Derek Ostertag, James B Elder, Stephen Bloomfield, Bob Carter, Clark C Chen, Steven N Kalkanis, Santosh Kesari, Albert Lai, Ian Y Lee, Linda M Liau, Tom Mikkelsen, Phioanh Nghiemphu, David Piccioni, William Accomando, Oscar R Diago, Daniel J Hogan, Dawn Gammon, Noriyuki Kasahara, Thian Kheoh, Douglas J Jolly, Harry E Gruber, Asha Das, Tobias Walbert
Background: Vocimagene amiretrorepvec (Toca 511) is an investigational gamma-retroviral replicating vector encoding cytosine deaminase that, when used in combination with extended-release 5-fluorocytosine (Toca FC), results preclinically in local production of 5-fluorouracil, depletion of immune-suppressive myeloid cells, and subsequent induction of anti-tumor immunity. Recurrent high grade glioma (rHGG) patients have a high unmet need for effective therapies that produce durable responses lasting more than 6 months...
May 12, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29762359/nitrous-oxide-and-decreased-white-matter-integrity-and-volume-during-childhood
#7
Kirk Hogan
No abstract text is available yet for this article.
June 2018: Anesthesiology
https://www.readbyqxmd.com/read/29760218/validation-of-an-expanded-carrier-screen-that-optimizes-sensitivity-via-full-exon-sequencing-and-panel-wide-copy-number-variant-identification
#8
Gregory J Hogan, Valentina S Vysotskaia, Kyle A Beauchamp, Stefanie Seisenberger, Peter V Grauman, Kevin R Haas, Sun Hae Hong, Diana Jeon, Shera Kash, Henry H Lai, Laura M Melroy, Mark R Theilmann, Clement S Chu, Kevin Iori, Jared R Maguire, Eric A Evans, Imran S Haque, Rebecca Mar-Heyming, Hyunseok P Kang, Dale Muzzey
BACKGROUND: By identifying pathogenic variants across hundreds of genes, expanded carrier screening (ECS) enables prospective parents to assess the risk of transmitting an autosomal recessive or X-linked condition. Detection of at-risk couples depends on the number of conditions tested, the prevalence of the respective diseases, and the screen's analytical sensitivity for identifying disease-causing variants. Disease-level analytical sensitivity is often <100% in ECS tests because copy number variants (CNVs) are typically not interrogated because of their technical complexity...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29759849/methicillin-resistant-staphylococcus-aureus-the-effects-are-more-than-skin-deep
#9
Carol E Muenks, Whitney C Sewell, Patrick G Hogan, Ryley M Thompson, David G Ross, Jeffrey W Wang, John J Morelli, Sarah J Gehlert, Stephanie A Fritz
OBJECTIVES: To assess the psychosocial effects of a methicillin-resistant Staphylococcus aureus (MRSA) diagnosis on the households of children with MRSA skin and soft tissue infection (SSTI). STUDY DESIGN: We constructed and administered an interview to the primary caregiver within the home of a child with a history of MRSA SSTI. RESULTS: Seventy-six households were enrolled. Survey responses were analyzed and grouped into 4 themes: health behavior changes, disclosure, social interactions, and knowledge/awareness...
May 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29759418/a-clone-directed-approach-may-improve-diagnosis-and-treatment-of-proliferative-glomerulonephritis-with-monoclonal-immunoglobulin-deposits
#10
Ramnika Gumber, Jordana B Cohen, Matthew B Palmer, Sidney M Kobrin, Dan T Vogl, Alan G Wasserstein, Sunita D Nasta, Melissa B Bleicher, Roy D Bloom, Laura Dember, Adam Cohen, Brendan M Weiss, Jonathan J Hogan
The optimal treatment for the monoclonal gammopathies of renal significance is not known, but there is consensus among experts that treatment should be specific for the underlying clone. The majority of patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) do not have an identifiable clone, and prior studies have found poor renal outcomes for patients with PGNMID treated with a variety of regimens. Here we present a retrospective case series of 19 patients with PGNMID with a more uniform, clone-directed approach...
May 11, 2018: Kidney International
https://www.readbyqxmd.com/read/29759012/using-the-replicating-effective-programs-framework-to-adapt-a-heart-health-intervention
#11
Jessica E Ramsay, Mary R Janevic, Cainnear K Hogan, Dominique L Edwards, Cathleen M Connell
Heart disease is the leading cause of death in the United States. African Americans and people of low socioeconomic status suffer disproportionately from heart disease-related morbidity and mortality. In Detroit, Michigan, a primarily African American and low-income urban area, heart disease mortality is at twice the national rate. Despite evidence for the effectiveness of self-management support interventions in reducing chronic disease burden for older adults, few are adapted for communities most in need...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29758400/a-method-to-quantify-and-value-floodplain-sediment-and-nutrient-retention-ecosystem-services
#12
Kristina G Hopkins, Gregory B Noe, Fabiano Franco, Emily J Pindilli, Stephanie Gordon, Marina J Metes, Peter R Claggett, Allen C Gellis, Cliff R Hupp, Dianna M Hogan
Floodplains provide critical ecosystem services to local and downstream communities by retaining floodwaters, sediments, and nutrients. The dynamic nature of floodplains is such that these areas can both accumulate sediment and nutrients through deposition, and export material downstream through erosion. Therefore, estimating floodplain sediment and nutrient retention should consider the net flux of both depositional and erosive processes. An ecosystem services framework was used to quantify and value the sediment and nutrient ecosystem service provided by floodplains in the Difficult Run watershed, a small (151 km2 ) suburban watershed located in the Piedmont of Virginia (USA)...
May 11, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29756924/controlling-the-local-electronic-properties-of-si-553-au-through-hydrogen-doping
#13
C Hogan, E Speiser, S Chandola, S Suchkova, J Aulbach, J Schäfer, S Meyer, R Claessen, N Esser
We propose a quantitative and reversible method for tuning the charge localization of Au-stabilized stepped Si surfaces by site-specific hydrogenation. This is demonstrated for Si(553)-Au as a model system by combining density functional theory simulations and reflectance anisotropy spectroscopy experiments. We find that controlled H passivation is a two-step process: step-edge adsorption drives excess charge into the conducting metal chain "reservoir" and renders it insulating, while surplus H recovers metallic behavior...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29753356/measurement-equivalence-of-patient-reported-outcome-measure-response-scale-types-collected-using-bring-your-own-device-compared-to-paper-and-a-provisioned-device-results-of-a-randomized-equivalence-trial
#14
Bill Byrom, Helen Doll, Willie Muehlhausen, Emuella Flood, Cater Cassedy, Bryan McDowell, Jeremy Sohn, Kyle Hogan, Ryan Belmont, Barbara Skerritt, Marie McCarthy
OBJECTIVES: The aim of this study was to assess the measurement equivalence of individual response scale types by using a patient reported outcome measure (PROM) collected on paper and migrated into electronic format for use on the subject's own mobile device (BYOD) and on a provisioned device (site device). METHODS: Subjects suffering from chronic health conditions causing daily pain or discomfort were invited to participate in this single-site, single visit, three-way crossover study...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29752503/correction-to-the-relationship-of-pelvic-incidence-to-post-operative-total-hip-arthroplasty-dislocation-in-patients-with-lumbar-fusion
#15
Philip J York, Alan W McGee, Chase S Dean, Justin E Hellwinkel, Christopher J Kleck, Michael R Dayton, Craig A Hogan
The original publication of this paper contain an error. The author name "Alan S. McGee Jr" is incorrect for it should have been "Alan W. McGee Jr".
May 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29752386/nppa-and-nppb-act-redundantly-during-zebrafish-cardiac-development-to-confine-avc-marker-expression-and-reduce-cardiac-jelly-volume
#16
Daniela R Grassini, Anne K Lagendijk, Jessica E De Angelis, Jason Da Silva, Angela Jeanes, Nicole Zettler, Neil I Bower, Benjamin M Hogan, Kelly A Smith
Atrial natriuretic peptide ( nppa/anf ) and brain natriuretic peptide ( nppb/bnp ) form a gene cluster with expression in the chambers of the developing heart. Despite restricted expression, a function in cardiac development has not been demonstrated by mutant analysis. This is attributed to functional redundancy however their genomic location in cis has impeded formal analysis. Using genome-editing, we generated mutants for nppa and nppb and found single mutants indistinguishable from wildtype whereas nppa / nppb double mutants display heart morphogenesis defects and pericardial oedema...
May 11, 2018: Development
https://www.readbyqxmd.com/read/29752282/niche-mediated-bmp-smad-signaling-regulates-lung-alveolar-stem-cell-proliferation-and-differentiation
#17
Mei-I Chung, Melissa Bujnis, Christina E Barkauskas, Yoshihiko Kobayashi, Brigid L M Hogan
The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its role in the alveolar region, where type 2 epithelial cells (AT2s) and Pdgfrα+ type 2-associated stromal cells (TASCs) are components of the stem cell niche. We use organoids and in vivo alveolar regrowth after pneumonectomy (PNX) - a process that requires proliferation of AT2s and differentiation into type 1 cells (AT1s)...
May 11, 2018: Development
https://www.readbyqxmd.com/read/29750526/modern-spin-on-the-electrochemical-persistence-of-heteroatom-bridged-triphenylmethyl-type-radicals
#18
David T Hogan, Todd C Sutherland
Herein we present a clarification of the ambiguous persistence of the 10-methyl-9-phenylacridanyl, 9-phenylxanthenyl and 9-phenylthioxanthenyl radicals in electrochemical experiments. Each of these radicals has separately been the subject of conflicting literature results for decades with publications claiming both their chemical inertness and propensity to dimerize. We assert that each radical is persistent at conventional electrochemical timescales up to several minutes based on reversible redox couples and cyclic voltammogram simulations of the radicals and their respective cations...
May 11, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29748956/neurobehavioral-evaluation-of-neonates-with-congenital-heart-disease-a-cohort-study
#19
Whitnee J Hogan, Sarah Winter, Nelangi M Pinto, Cindy Weng, Xiaoming Sheng, Elisabeth Conradt, Janine Wood, Michael D Puchalski, Lloyd Y Tani, Thomas A Miller
AIM: To describe neurobehavioral patterns in neonates with congenital heart disease (CHD). METHOD: A cohort study describing neurobehavioral performance of neonates with CHD requiring cardiac surgery. The neonates were evaluated preoperatively and postoperatively with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) and scores were compared with published normative values. Clinical factors were obtained by chart review to assess their association with behavior...
May 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29747985/challenges-for-the-clinician-physical-activity-among-severe-asthmatic-patients-with-comorbid-obesity
#20
EDITORIAL
Sheniz Moonie, Mary Beth Hogan
No abstract text is available yet for this article.
May 2018: Journal of Allergy and Clinical Immunology in Practice
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