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https://www.readbyqxmd.com/read/27932520/myeloid-derived-nf-%C3%AE%C2%BAb-negative-regulation-of-pu-1-and-c-ebp-%C3%AE-driven-pro-inflammatory-cytokine-production-restrains-lps-induced-shock
#1
Simone Vanoni, Yi-Ting Tsai, Amanda Waddell, Lisa Waggoner, Jared Klarquist, Senad Divanovic, Kasper Hoebe, Kris A Steinbrecher, Simon P Hogan
Sepsis is a life-threatening event predominantly caused by Gram-negative bacteria. Bacterial infection causes a pronounced macrophage (MΦ) and dendritic cell activation that leads to excessive pro-inflammatory cytokine IL-1β, IL-6 and TNF-α production (cytokine storm), resulting in endotoxic shock. Previous experimental studies have revealed that inhibiting NF-κB signaling ameliorates disease symptoms; however, the contribution of myeloid p65 in endotoxic shock remains elusive. In this study, we demonstrate increased mortality in mice lacking p65 in the myeloid lineage (p65(Δmye)) compared with wild type mice upon ultra-pure LPS challenge...
December 8, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27928501/patient-prioritization-of-comorbid-chronic-conditions-in-the-veteran-population-implications-for-patient-centered-care
#2
Lorilei M Richardson, Jennifer N Hill, Bridget M Smith, Erica Bauer, Frances M Weaver, Howard S Gordon, Kevin T Stroupe, Timothy P Hogan
OBJECTIVE: Patients with comorbid chronic conditions may prioritize some conditions over others; however, our understanding of factors influencing those prioritizations is limited. In this study, we sought to identify and elaborate a range of factors that influence how and why patients with comorbid chronic conditions prioritize their conditions. METHODS: We conducted semi-structured, one-on-one interviews with 33 patients with comorbidities recruited from a single Veterans Health Administration Medical Center...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27921082/global-role-of-cyclic-amp-signaling-in-ph-dependent-responses-in-candida-albicans
#3
Jeffrey M Hollomon, Nora Grahl, Sven D Willger, Katja Koeppen, Deborah A Hogan
Candida albicans behaviors are affected by pH, an important environmental variable. Filamentous growth is a pH-responsive behavior, where alkaline conditions favor hyphal growth and acid conditions favor growth as yeast. We employed filamentous growth as a tool to study the impact of pH on the hyphal growth regulator Cyr1, and we report that downregulation of cyclic AMP (cAMP) signaling by acidic pH contributes to the inhibition of hyphal growth in minimal medium with GlcNAc. Ras1 and Cyr1 are generally required for efficient hyphal growth, and the effects of low pH on Ras1 proteolysis and GTP binding are consistent with diminished cAMP output...
November 2016: MSphere
https://www.readbyqxmd.com/read/27918001/evolution-of-skin-and-hair-in-african-americans
#4
Angela Kyei, Sara Hogan
Current demographic trends in the United States highlight the growing population of those who identify as having "skin of color." As such, dermatologists must have a greater comfort level and knowledge in treating some of the unique skin and hair conditions seen in this population. Understanding the scientific basis for the evolution of skin color and hair texture is necessary in order to understand the variations in the characteristics of skin and hair seen among racial and ethnic groups. This review seeks to highlight the current scientific explanation of skin color and hair texture, with special attention to people of African descent, in an attempt to give insight into the clinical presentations of hair and skin disorders seen in this group...
December 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27914948/triazolopyridine-ethers-as-potent-orally-active-mglu2-positive-allosteric-modulators-for-treating-schizophrenia
#5
Mendi A Higgins, Lawrence R Marcin, F Christopher Zusi, Robert Gentles, Min Ding, Bradley C Pearce, Amy Easton, Walter A Kostich, Matthew A Seager, Clotilde Bourin, Linda J Bristow, Kim A Johnson, Regina Miller, John Hogan, Valerie Whiterock, Michael Gulianello, Meredith Ferrante, Yanling Huang, Adam Hendricson, Andrew Alt, John E Macor, Joanne J Bronson
Triazolopyridine ethers with mGlu2 positive allosteric modulator (PAM) activity are disclosed. The synthesis, in vitro activity, and metabolic stability data for a series of analogs is provided. The effort resulted in the discovery of a potent, selective, and brain penetrant lead molecule BMT-133218 ((+)-7m). After oral administration at 10mg/kg, BMT-133218 demonstrated full reversal of PCP-stimulated locomotor activity and prevented MK-801-induced working memory deficits in separate mouse models. Also, reversal of impairments in executive function were observed in rat set-shifting studies at 3 and 10mg/kg (p...
November 14, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27908751/enhanced-potency-of-bivalent-small-molecule-gp41-inhibitors
#6
Vladimir Sofiyev, Hardeep Kaur, Beth A Snyder, Priscilla A Hogan, Roger G Ptak, Peter Hwang, Miriam Gochin
Low molecular weight peptidomimetic inhibitors with hydrophobic pocket binding properties and moderate fusion inhibitory activity against HIV-1 gp41-mediated cell fusion were elaborated by increasing the available surface area for interacting with the heptad repeat-1 (HR1) coiled coil on gp41. Two types of modifications were tested: 1) increasing the overall hydrophobicity of the molecules with an extension that could interact in the HR1 groove, and 2) forming symmetrical dimers with two peptidomimetic motifs that could potentially interact simultaneously in two hydrophobic pockets on the HR1 trimer...
November 19, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27906753/noninvasive-markers-of-liver-fibrosis-on-treatment-changes-of-serum-markers-predict-the-outcome-of-antifibrotic-therapy
#7
Sudeep Tanwar, Paul M Trembling, Brian J Hogan, Ankur Srivastava, Julie Parkes, Scott Harris, Paul Grant, Eleni Nastouli, Mathias Ocker, Klaus Wehr, Christoph Herold, Daniel Neureiter, Detlef Schuppan, William M Rosenberg
AIM: The utility of noninvasive serum markers to longitudinally monitor liver fibrosis is not established. METHODS: A total of 70 patients with chronic hepatitis C who had previously failed antiviral therapy were randomized to receive pegylated interferon with or without silymarin for 24 months. Enhanced Liver Fibrosis (ELF) tests (hyularonic acid, terminal peptide of procollagen III, tissue inhibitor of matrix metaloproteinase-1) were performed on patient sera obtained before, during and at the end of the study (0, 12, 24 months) and liver histology obtained before and at the end of the study...
November 30, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27902568/health-utilities-in-people-with-chronic-pain-using-a-population-level-survey-and-linked-healthcare-administrative-data
#8
Mary-Ellen Hogan BScPhm, Anna Taddio BScPhm, Joel Katz, Vibhuti Shah, Murray Krahn
Health utilities are a preference-based measure of health-related quality of life that facilitates comparison of disease burden across conditions. We estimated utilities using a population-based, matched sample of adolescents and adults with and without chronic pain, controlling for comorbidity.Ontarians aged ≥12 years with and without chronic pain were identified from the Canadian Community Health Survey (CCHS) 2000-01 and 2009-10 and linked to their provincial healthcare administrative data. Individuals with chronic pain were matched to those without using age, sex, survey year, and a propensity score for having chronic pain estimated from a rurality index, income quintile and comorbidity...
November 24, 2016: Pain
https://www.readbyqxmd.com/read/27898928/predicting-pork-loin-chop-yield-using-carcass-and-loin-characteristics
#9
K B Wilson, M F Overholt, E K Hogan, C Schwab, C M Shull, M Ellis, N S Grohmann, A C Dilger, D D Boler
The objective was to determine the predictive ability of carcass length for the number of equal-thickness chops obtained from a boneless pork loin. Longer pork carcasses are assumed to yield longer loins and, therefore, an increased number of chops. Loins were collected from pigs (1,238 total) raised under commercial conditions and marketed when the mean pig weight in a pen reached 138 kg. Pigs were slaughtered over 7 wk in a commercial facility. Carcass length was measured at 1 d postmortem on the left side of each carcass from the anterior edge of the symphysis pubis bone to the anterior edge of the first rib...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895053/utilising-polymorphisms-to-achieve-allele-specific-genome-editing-in-zebrafish
#10
Samuel J Capon, Gregory J Baillie, Neil I Bower, Jason A da Silva, Scott Paterson, Benjamin M Hogan, Cas Simons, Kelly A Smith
The advent of genome editing has significantly altered genetic research, including research using the zebrafish model. To better understand the selectivity of the commonly used CRISPR/Cas9 system, we investigated single base pair mismatches in target sites and examined how they affect genome editing in the zebrafish model. Using two different zebrafish strains that have been deep sequenced, CRISPR/Cas9 target sites containing polymorphisms between the two strains were identified. These strains were crossed (creating heterozygotes at polymorphic sites) and CRISPR/Cas9 complexes that perfectly complement one strain injected...
November 28, 2016: Biology Open
https://www.readbyqxmd.com/read/27893026/prevalence-of-depression-in-patients-with-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#11
Zahinoor Ismail, Heba Elbayoumi, Corinne E Fischer, David B Hogan, Colleen P Millikin, Tom Schweizer, Moyra E Mortby, Eric E Smith, Scott B Patten, Kirsten M Fiest
Importance: Depression is common in individuals with mild cognitive impairment (MCI) and may confer a higher likelihood of progression to dementia. Prevalence estimates of depression in those with MCI are required to guide both clinical decisions and public health policy, but published results are variable and lack precision. Objective: To provide a precise estimate of the prevalence of depression in individuals with MCI and identify reasons for heterogeneity in the reported results...
November 23, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27885776/multidisciplinary-care-ensures-successful-pregnancy-following-intestinal-transplantation-a-case-report
#12
V Blackwell, L Holdaway, J Hogan, J Gilbert, S Sinha, G Vrakas, S Reddy, P Friend, L Mackillop, D Harrington, C Greenwood, A Vaidya, P J Allan
No abstract text is available yet for this article.
November 24, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27881361/older-veteran-digital-disparities-examining-the-potential-for-solutions-within-social-networks
#13
Tana M Luger, Timothy P Hogan, Lorilei M Richardson, Lisa Cioffari-Bailiff, Kimberly Harvey, Thomas K Houston
BACKGROUND: Older adults typically have less access to the Internet than other age groups, and older Veterans may use the Internet even less due to economic and geographic reasons. OBJECTIVE: To explore solutions to this problem, our study examined older Veterans' reported ability to access technology through their close social ties. METHODS: Data were collected via mail survey from a sample of Veterans aged 65 years and older (N=266). RESULTS: Nearly half (44...
November 23, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27876686/encouraging-patient-portal-use-in-the-patient-centered-medical-home-three-stakeholder-perspectives
#14
Gemmae M Fix, Timothy P Hogan, Daniel J Amante, D Keith McInnes, Kim M Nazi, Steven R Simon
BACKGROUND: Health care organizations are increasingly offering patients access to their electronic medical record and the ability to communicate with their providers through Web-based patient portals, thus playing a prominent role within the patient-centered medical home (PCMH). However, despite enthusiasm, adoption remains low. OBJECTIVE: We examined factors in the PCMH context that may affect efforts to improve enrollment in a patient portal. METHODS: Using a sociotechnical approach, we conducted qualitative, semistructured interviews with patients and providers from 3 primary care clinics and with national leaders from across a large integrated health care system...
November 22, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27876655/dorsal-root-ganglion-stimulation-attenuates-the-bold-signal-response-to-noxious-sensory-input-in-specific-brain-regions-insights-into-a-possible-mechanism-for-analgesia
#15
Christopher P Pawela, Jeffery M Kramer, Quinn H Hogan
Targeted dorsal root ganglion (DRG) electrical stimulation (i.e. ganglionic field stimulation - GFS) is an emerging therapeutic approach to alleviate chronic pain. Here we describe blood oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI) responses to noxious hind-limb stimulation in a rat model that replicates clinical GFS using an electrode implanted adjacent to the DRG. Acute noxious sensory stimulation in the absence of GFS caused robust BOLD fMRI response in brain regions previously associated with sensory and pain-related response, such as primary/secondary somatosensory cortex, retrosplenial granular cortex, thalamus, caudate putamen, nucleus accumbens, globus pallidus, and amygdala...
November 19, 2016: NeuroImage
https://www.readbyqxmd.com/read/27875636/evaluation-of-coronary-artery-disease-in-potential-liver-transplant-recipients
#16
REVIEW
Brian J Hogan, Enoka Gonsalkorala, Michael A Heneghan
Improvements in the management of patients undergoing Liver Transplantation (LT) have resulted in a significant increase in survival over recent years. Cardiac disease is now the leading cause of early mortality and the stress of major surgery, haemodynamic shifts, the possibility of haemorrhage or reperfusion syndrome require the recipient to have good baseline cardiac function. The prevalence of coronary artery disease (CAD) is increasing in liver transplant candidates, especially in those with Non-Alcohol related Fatty Liver Disease (NAFLD)...
November 22, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27870582/markers-of-islet-endothelial-dysfunction-occur-in-male-db-db-mice-and-may-contribute-to-reduced-insulin-release
#17
Meghan F Hogan, Amy W Liu, Michael J Peters, Joshua R Willard, Zaheen Rabbani, Erik C Bartholomew, Adam Ottley, Rebecca L Hull
Islet endothelial cells produce paracrine factors that support β-cell function and growth. Endothelial dysfunction underlies diabetic microvascular complications; thus we hypothesized that in diabetes, islet endothelial cells become dysfunctional and this may contribute to β-cell secretory dysfunction. Islets/islet endothelial cells were isolated from diabetic db/db mice, treated with or without the glucose-lowering agent phlorizin, or C57BL/6J mice fed a high fat diet for 18 weeks (and appropriate controls)...
November 21, 2016: Endocrinology
https://www.readbyqxmd.com/read/27869616/tet2-and-tet3-cooperate-with-b-lineage-transcription-factors-to-regulate-dna-modification-and-chromatin-accessibility
#18
Chan-Wang Lio, Jiayuan Zhang, Edahí González-Avalos, Patrick G Hogan, Xing Chang, Anjana Rao
Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine, facilitating DNA demethylation and generating new epigenetic marks. Here we show that concomitant loss of Tet2 and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igκ locus. Tet2/3-deficient pro-B cells showed increased CpG methylation at the Igκ 3' and distal enhancers that was mimicked by depletion of E2A or PU...
November 21, 2016: ELife
https://www.readbyqxmd.com/read/27866346/comparing-the-effects-of-an-acute-bout-of-physical-exercise-with-an-acute-bout-of-interactive-mental-and-physical-exercise-on-electrophysiology-and-executive-functioning-in-younger-and-older-adults
#19
Julia Dimitrova, Michael Hogan, Patrick Khader, Denis O'Hora, Liam Kilmartin, Jane C Walsh, Richard Roche, Cay Anderson-Hanley
BACKGROUND: Physical exercise has been shown to improve cognitive and neural functioning in older adults. AIMS AND METHODS: The current study compared the effects of an acute bout of physical exercise with a bout of interactive mental and physical exercise (i.e., "exergaming") on executive (Stroop) task performance and event-related potential (ERP) amplitudes in younger and older adults. RESULTS: Results revealed enhanced executive task performance in younger and older adults after exercise, with no differences in performance between exercise conditions...
November 19, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27861182/cryopreserved-xeno-free-human-umbilical-cord-mesenchymal-stromal-cells-reduce-lung-injury-severity-and-bacterial-burden-in-rodent-escherichia-coli-induced-acute-respiratory-distress-syndrome
#20
Gerard F Curley, Mirjana Jerkic, Steve Dixon, Grace Hogan, Claire Masterson, Daniel O'Toole, James Devaney, John G Laffey
OBJECTIVE: Although mesenchymal stem/stromal cells represent a promising therapeutic strategy for acute respiratory distress syndrome, clinical translation faces challenges, including scarcity of bone marrow donors, and reliance on bovine serum during mesenchymal stem/stromal cell proliferation. We wished to compare mesenchymal stem/stromal cells from human umbilical cord, grown in xeno-free conditions, with mesenchymal stem/stromal cells from human bone marrow, in a rat model of Escherichia coli pneumonia...
November 16, 2016: Critical Care Medicine
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