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https://www.readbyqxmd.com/read/28492042/classifying-discoid-lupus-erythematosus-background-gaps-and-difficulties
#1
REVIEW
Jessica S Haber, Joseph F Merola, Victoria P Werth
To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database. A search was performed to identify studies reporting criteria used to distinguish DLE from other cutaneous lupus erythematosus subtypes. We examined which clinical, histopathologic, and serologic features have data to support their use as effective features in distinguishing DLE from other potential disease mimickers and cutaneous lupus subsets...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28483542/pathogenesis-of-cutaneous-lupus-erythema-associated-with-and-without-systemic-lupus-erythema
#2
REVIEW
Yu-Ping Zhang, Jian Wu, Yan-Fang Han, Zhen-Rui Shi, Liangchun Wang
Cutaneous lupus erythematosus(CLE) can be an individual disease only involving skin, or presents as part of the manifestations of SLE. A small proportion of CLE may progress into SLE, however, the underlying pathogenic mediators remain elusive. By only including researches that clearly described if the subtypes of CLE presented by enrolled subjects was associated with or without SLE, we provided an overview of antibodies, inflammatory cells and inflammatory molecular mediators identified in blood and skin that were possibly involved in lupus skin damages...
May 5, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28476075/drugs-for-discoid-lupus-erythematosus
#3
REVIEW
Sue Jessop, David A Whitelaw, Matthew J Grainge, Prativa Jayasekera
BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of a Cochrane Review first published in 2000, and previously updated in 2009. We wanted to update the review to assess whether any new information was available to treat DLE, as we were still unsure of the effectiveness of available drugs and how to select the most appropriate treatment for an individual with DLE...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28400654/discoid-lupus-and-human-immunodeficiency-virus-a-retrospective-chart-review-to-determine-the-prevalence-and-progression-of-co-occurrence-of-these-conditions-at-a-single-academic-center
#4
Aimee Two, Jessica Kim So, Taraneh Paravar
CONTEXT: Discoid lupus erythematosus (DLE) and human immunodeficiency virus (HIV) are both disorders of the immune system. The pathophysiology of these diseases varies greatly as DLE is characterized by an overactive immune system that attacks normal host cells, whereas HIV is characterized by an exogenous attack on the immune system that depletes it of key cell types. Although the reason is unknown, co-occurrence of DLE and HIV is rare. AIMS: The goal of this study is to determine the prevalence of co-occurrence of DLE and HIV and to determine whether patients with both DLE and HIV share any clinical feature...
March 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28396162/phase-i-study-of-clofarabine-and-2-gy-total-body-irradiation-as-a-nonmyeloablative-preparative-regimen-for-hematopoietic-stem-cell-transplantation-in-pediatric-patients-with-hematologic-malignancies-a-therapeutic-advances-in-childhood-leukemia-consortium-study
#5
Sandeep Soni, Hisham Abdel-Azim, Meghann McManus, Eneida Nemecek, Richard Sposto, Ann Woolfrey, Haydar Frangoul
Clofarabine is a purine nucleoside analog with immunosuppressive and antileukemic activity and its inclusion in reduced-intensity regimens could potentially improve outcomes. We performed a prospective phase I study of clofarabine combined with 2 Gy total body irradiation (TBI) as a nonmyeloablative preparative regimen for allogeneic stem cell transplantation in pediatric patients who were considered at high risk of mortality from standard myeloablative regimens. The main goal of the study was to delineate the maximum feasible dose (MFD) of clofarabine in combination with 2 Gy TBI...
April 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28386549/anti-inflammatory-effect-of-dialyzable-leukocyte-extract-in-autoimmune-prostatitis-evaluation-in-animal-model
#6
Carlos Pérez-Alvarado, Consuelo Gómez, Miguel Reyes, Mario García, Elizabeth Pérez, Carlos Pérez de la Mora, Virginia Sanchez, D Guillermo Pérez Ishiwara
Objective. To evaluate the anti-inflammatory properties of Dialyzable Leukocyte Extract (DLE) in a murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods. Histopathological characterization, prostatein Enzyme-Linked Immunosorbent Assay, and immunohistochemical analysis for CD45, TNF-α, IFN-γ, IL-6, IL-17, and IL-4 molecules were done in prostatic Wistar rats treated with DLE, placebo, or Dexamethasone. Results. Histopathological analysis of animals induced to prostatitis showed inflammatory infiltrate, mainly constituted by leucocytes and mast cells as well as Benign Prostatic Hyperplasia...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28329473/successful-treatment-of-recalcitrant-discoid-lupus-erythematosus-with-ustekinumab
#7
Alberto Romero-Maté, Carmen García-Donoso, Almudena Hernández-Núñez, Cristina Martínez-Morán, Amalia Moreno-Torres, Jesús Borbujo-Martínez
We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Fortyeight months later stable improvement was achievedwithout side effects. Only nine patients with cutaneouslupus erythematosus (CLE) treated with ustekinumabhave been reported to date...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28282783/diospyros-lotus-leaf-and-grapefruit-stem-extract-synergistically-ameliorate-atopic-dermatitis-like-skin-lesion-in-mice-by-suppressing-infiltration-of-mast-cells-in-skin-lesions
#8
Byoung Ok Cho, Denis Nchang Che, Hong Hua Yin, Jae Young Shin, Seon Il Jang
Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of Diospyros lotus leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28266209/direct-liquid-evaporation-chemical-vapor-deposition-of-nanocrystalline-cobalt-metal-for-nanoscale-copper-interconnect-encapsulation
#9
Jun Feng, Xian Gong, Xiabing Lou, Roy G Gordon
In advanced microelectronics, precise design of liner and capping layers become critical, especially when it comes to the fabrication of Cu interconnects with dimensions lower than its mean free path. Herein, we demonstrate that direct-liquid-evaporation chemical vapor deposition (DLE-CVD) of Co is a promising method to make liner and capping layers for nanoscale Cu interconnects. DLE-CVD makes pure, smooth, nanocrystalline, and highly conformal Co films with highly controllable growth characteristics. This process allows full Co encapsulation of nanoscale Cu interconnects, thus stabilizing Cu against diffusion and electromigration...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28255361/intracellularly-swollen-polypeptide-nanogel-assists-hepatoma-chemotherapy
#10
Bo Shi, Kexin Huang, Jianxun Ding, Weiguo Xu, Yu Yang, Haiyan Liu, Lesan Yan, Xuesi Chen
Nowadays, chemotherapy is one of the principal modes of treatment for tumor patients. However, the traditional formulations of small molecule drugs show short circulation time, low tumor selectivity, and high toxicity to normal tissues. To address these problems, a facilely prepared, and pH and reduction dual-responsive polypeptide nanogel was prepared for selectively intracellular delivery of chemotherapy drug. As a model drug, doxorubicin (DOX) was loaded into the nanogel through a sequential dispersion and dialysis technique, resulting in a high drug loading efficiency (DLE) of 96...
2017: Theranostics
https://www.readbyqxmd.com/read/28199904/cyclic-electron-flow-may-provide-some-protection-against-psii-photoinhibition-in-rice-oryza-sativa-l-leaves-under-heat-stress
#11
Jemaa Essemine, Yi Xiao, Mingnan Qu, Hualing Mi, Xin-Guang Zhu
Previously we have shown that a quick down-regulation in PSI activity compares to that of PSII following short-term heat stress for two rice groups including C4023 and Q4149, studied herein. These accessions were identified to have different natural capacities in driving cyclic electron flow (CEF) around PSI; i.e., low CEF (lcef) and high CEF (hcef) for C4023 and Q4149, respectively. The aim of this study was to investigate whether these two lines have different mechanisms of protecting photosystem II from photodamage under heat stress...
April 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28169048/creating-a-drug-law-enforcement-research-agenda
#12
Peter Reuter
Drug law enforcement (DLE) research has been poorly funded relative to drug treatment research. The literature is slight in volume and not yet very insightful. Taking the lack of funding to represent a chronic lack of public interest in the effects of DLE, the article offers a set of suggestions for how to create of a stronger DLE research community.
February 3, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28133824/a-retrospective-study-comparing-histopathological-and-immunopathological-features-of-nasal-planum-dermatitis-in-20-dogs-with-discoid-lupus-erythematosus-or-leishmaniosis
#13
Michela De Lucia, Giorgia Mezzalira, Mar Bardagí, Dolors M Fondevila, Elisabetta Fabbri, Alessandra Fondati
BACKGROUND: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs. HYPOTHESIS/OBJECTIVE: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL. ANIMALS: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6)...
January 29, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28127570/high-prevalence-of-metabolic-syndrome-in-patients-with-discoid-lupus-erythematosus-a-cross-sectional-case-control-study
#14
Sevgi Akarsu, Ozlem Ozbagcivan, Fatma Semiz, Sebnem Aktan
Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28118537/pharmacodynamics-safety-and-clinical-efficacy-of-amg-811-a-human-anti-interferon-%C3%AE-antibody-in-patients-with-discoid-lupus-erythematosus
#15
Victoria P Werth, David Fiorentino, Barbara A Sullivan, Michael J Boedigheimer, Kit Chiu, Christine Wang, Gregory E Arnold, Michael A Damore, Jeannette Bigler, Andrew A Welcher, Chris B Russell, David A Martin, James B Chung
OBJECTIVE: Interferon-γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811, an anti-IFNγ antibody, in patients with DLE. METHODS: The study was designed as a phase I randomized, double-blind, placebo-controlled crossover study of the pharmacodynamics, safety, and clinical efficacy of AMG 811 in patients with DLE. Patients received a single subcutaneous dose of AMG 811 (180 mg) or placebo...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28003050/microbial-community-structures-in-high-rate-algae-ponds-for-bioconversion-of-agricultural-wastes-from-livestock-industry-for-feed-production
#16
A Mark Ibekwe, Shelton E Murinda, Marcia A Murry, Gregory Schwartz, Trygve Lundquist
Dynamics of seasonal microbial community compositions in algae cultivation ponds are complex. However, there is very limited knowledge on bacterial communities that may play significant roles with algae in the bioconversion of manure nutrients to animal feed. In this study, water samples were collected during winter, spring, summer, and fall from the dairy lagoon effluent (DLE), high rate algae ponds (HRAP) that were fed with diluted DLE, and municipal waste water treatment plant (WWTP) effluent which was included as a comparison system for the analysis of total bacteria, Cyanobacteria, and microalgae communities using MiSeq Illumina sequencing targeting the 16S V4 rDNA region...
February 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27968927/autoimmune-collagen-vascular-diseases-kids-are-not-just-little-people
#17
Sean Timpane, Heather Brandling-Bennett, Arni K Kristjansson
Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Children often need early aggressive systemic treatment to try to prevent long-term sequelae of morphea...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27878284/antitumor-effect-of-the-combination-of-manumycin%C3%A2-a-and-immodin-is-associated-with-antiplatelet-activity-and-increased-granulocyte-tumor-infiltration-in-a-4t1-breast-tumor-model
#18
Peter Solár, Veronika Sačková, Gabriela Hrčková, Vlasta Demečková, Monika Kassayová, Bianka Bojková, Dagmar Mudroňová, Soňa Gancarčíková, Rastislav Jendželovský, Peter Fedoročko
Manumycin A is a natural antibiotic isolated from Streptomyces parvulus with broad range of biological activities including antineoplastic activity in several in vitro and in vivo cancer models. Immodin [dialyzable leukocyte extract (DLE)] is a dialysate released from disintegrated blood leukocytes of healthy donors which exerts immunonormalizing effects on cell-mediated immune responses. The aim of the present study was to explore the antitumor potential of the combination of manumycin A and Immodin in an experimental breast cancer model...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27847830/early-differentiation-of-human-cd11c-nk-cells-with-%C3%AE-%C3%AE-t-cell-activation-properties-is-promoted-by-dialyzable-leukocyte-extracts
#19
Dalia Ramírez-Ramírez, Eduardo Vadillo, Lourdes Andrea Arriaga-Pizano, Héctor Mayani, Sergio Estrada-Parra, Marco Antonio Velasco-Velázquez, Sonia Mayra Pérez-Tapia, Rosana Pelayo
Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as supportive therapy in both infectious and malignant settings has increased, its activity on the earliest stages of human hematopoietic development remains poorly understood. Here, we have examined the ability of DLE to promote replenishment of functional lymphoid lineages from CD34(+) cells...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27744707/optimization-of-curcumin-loaded-peg-plga-nanoparticles-by-gsh-functionalization-investigation-of-the-internalization-pathway-in-neuronal-cells
#20
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using polylactic-co-glycolic acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However, the route of internalization of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterized glutathione-functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
January 3, 2017: Molecular Pharmaceutics
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