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https://www.readbyqxmd.com/read/28329473/successful-treatment-of-recalcitrant-discoid-lupus-erythematosus-with-ustekinumab
#1
Alberto Romero-Maté, Carmen García-Donoso, Almudena Hernández-Núñez, Cristina Martínez-Morán, Amalia Moreno-Torres, Jesús Borbujo-Martínez
We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Fortyeight months later stable improvement was achievedwithout side effects. Only nine patients with cutaneouslupus erythematosus (CLE) treated with ustekinumabhave been reported to date...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28282783/diospyros-lotus-leaf-and-grapefruit-stem-extract-synergistically-ameliorate-atopic-dermatitis-like-skin-lesion-in-mice-by-suppressing-infiltration-of-mast-cells-in-skin-lesions
#2
Byoung Ok Cho, Denis Nchang Che, Hong Hua Yin, Jae Young Shin, Seon Il Jang
Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of Diospyros lotus leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice...
March 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28266209/direct-liquid-evaporation-chemical-vapor-deposition-of-nanocrystalline-cobalt-metal-for-nanoscale-copper-interconnect-encapsulation
#3
Jun Feng, Xian Gong, Xiabing Lou, Roy G Gordon
In advanced microelectronics, precise design of liner and capping layers becomes critical, especially when it comes to the fabrication of Cu interconnects with dimensions lower than its mean free path. Herein, we demonstrate that direct-liquid-evaporation chemical vapor deposition (DLE-CVD) of Co is a promising method to make liner and capping layers for nanoscale Cu interconnects. DLE-CVD makes pure, smooth, nanocrystalline and highly conformal Co films with highly controllable growth characteristics. This process allows full Co encapsulation of nanoscale Cu interconnects, thus stabilizing Cu against diffusion and electromigration...
March 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28255361/intracellularly-swollen-polypeptide-nanogel-assists-hepatoma-chemotherapy
#4
Bo Shi, Kexin Huang, Jianxun Ding, Weiguo Xu, Yu Yang, Haiyan Liu, Lesan Yan, Xuesi Chen
Nowadays, chemotherapy is one of the principal modes of treatment for tumor patients. However, the traditional formulations of small molecule drugs show short circulation time, low tumor selectivity, and high toxicity to normal tissues. To address these problems, a facilely prepared, and pH and reduction dual-responsive polypeptide nanogel was prepared for selectively intracellular delivery of chemotherapy drug. As a model drug, doxorubicin (DOX) was loaded into the nanogel through a sequential dispersion and dialysis technique, resulting in a high drug loading efficiency (DLE) of 96...
2017: Theranostics
https://www.readbyqxmd.com/read/28199904/cyclic-electron-flow-may-provide-some-protection-against-psii-photoinhibition-in-rice-oryza-sativa-l-leaves-under-heat-stress
#5
Jemaa Essemine, Yi Xiao, Mingnan Qu, Hualing Mi, Xin-Guang Zhu
Previously we have shown that a quick down-regulation in PSI activity compares to that of PSII following short-term heat stress for two rice groups including C4023 and Q4149, studied herein. These accessions were identified to have different natural capacities in driving cyclic electron flow (CEF) around PSI; i.e., low CEF (lcef) and high CEF (hcef) for C4023 and Q4149, respectively. The aim of this study was to investigate whether these two lines have different mechanisms of protecting photosystem II from photodamage under heat stress...
April 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28169048/creating-a-drug-law-enforcement-research-agenda
#6
Peter Reuter
Drug law enforcement (DLE) research has been poorly funded relative to drug treatment research. The literature is slight in volume and not yet very insightful. Taking the lack of funding to represent a chronic lack of public interest in the effects of DLE, the article offers a set of suggestions for how to create of a stronger DLE research community.
February 3, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28133824/a-retrospective-study-comparing-histopathological-and-immunopathological-features-of-nasal-planum-dermatitis-in-20-dogs-with-discoid-lupus-erythematosus-or-leishmaniosis
#7
Michela De Lucia, Giorgia Mezzalira, Mar Bardagí, Dolors M Fondevila, Elisabetta Fabbri, Alessandra Fondati
BACKGROUND: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs. HYPOTHESIS/OBJECTIVE: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL. ANIMALS: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6)...
January 29, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28127570/high-prevalence-of-metabolic-syndrome-in-patients-with-discoid-lupus-erythematosus-a-cross-sectional-case-control-study
#8
Sevgi Akarsu, Ozlem Ozbagcivan, Fatma Semiz, Sebnem Aktan
Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28118537/pharmacodynamics-safety-and-clinical-efficacy-of-amg-811-a-human-anti-interferon-%C3%AE-antibody-in-subjects-with-discoid-lupus-erythematosus
#9
Victoria P Werth, David Fiorentino, Barbara A Sullivan, Michael J Boedigheimer, Kit Chiu, Christine Wang, Gregory E Arnold, Michael A Damore, Jeannette Bigler, Andrew A Welcher, Chris B Russell, David A Martin, James B Chung
OBJECTIVE: Interferon (IFN)-γ is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study evaluated a single dose of AMG 811, an anti-IFN-γ antibody, in subjects with DLE. METHODS: This was a phase 1, randomized, double-blind, placebo-controlled, crossover study (sequence 1: AMG 811 followed by placebo; sequence 2: placebo followed by AMG 811). Subjects received a single subcutaneous dose of AMG 811 (180 mg) or placebo. Pharmacodynamic endpoints included global transcriptional analyses of lesional and nonlesional skin, IFN-γ Blockade Signature (IGBS) transcriptional score in skin and blood, keratinocyte IFN-γ RNA score, and serum CXCL-10 protein...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28003050/microbial-community-structures-in-high-rate-algae-ponds-for-bioconversion-of-agricultural-wastes-from-livestock-industry-for-feed-production
#10
A Mark Ibekwe, Shelton E Murinda, Marcia A Murry, Gregory Schwartz, Trygve Lundquist
Dynamics of seasonal microbial community compositions in algae cultivation ponds are complex. However, there is very limited knowledge on bacterial communities that may play significant roles with algae in the bioconversion of manure nutrients to animal feed. In this study, water samples were collected during winter, spring, summer, and fall from the dairy lagoon effluent (DLE), high rate algae ponds (HRAP) that were fed with diluted DLE, and municipal waste water treatment plant (WWTP) effluent which was included as a comparison system for the analysis of total bacteria, Cyanobacteria, and microalgae communities using MiSeq Illumina sequencing targeting the 16S V4 rDNA region...
February 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27968927/autoimmune-collagen-vascular-diseases-kids-are-not-just-little-people
#11
Sean Timpane, Heather Brandling-Bennett, Arni K Kristjansson
Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Children often need early aggressive systemic treatment to try to prevent long-term sequelae of morphea...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27878284/antitumor-effect-of-the-combination-of-manumycin%C3%A2-a-and-immodin-is-associated-with-antiplatelet-activity-and-increased-granulocyte-tumor-infiltration-in-a-4t1-breast-tumor-model
#12
Peter Solár, Veronika Sačková, Gabriela Hrčková, Vlasta Demečková, Monika Kassayová, Bianka Bojková, Dagmar Mudroňová, Soňa Gancarčíková, Rastislav Jendželovský, Peter Fedoročko
Manumycin A is a natural antibiotic isolated from Streptomyces parvulus with broad range of biological activities including antineoplastic activity in several in vitro and in vivo cancer models. Immodin [dialyzable leukocyte extract (DLE)] is a dialysate released from disintegrated blood leukocytes of healthy donors which exerts immunonormalizing effects on cell-mediated immune responses. The aim of the present study was to explore the antitumor potential of the combination of manumycin A and Immodin in an experimental breast cancer model...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27847830/early-differentiation-of-human-cd11c-nk-cells-with-%C3%AE-%C3%AE-t-cell-activation-properties-is-promoted-by-dialyzable-leukocyte-extracts
#13
Dalia Ramírez-Ramírez, Eduardo Vadillo, Lourdes Andrea Arriaga-Pizano, Héctor Mayani, Sergio Estrada-Parra, Marco Antonio Velasco-Velázquez, Sonia Mayra Pérez-Tapia, Rosana Pelayo
Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as supportive therapy in both infectious and malignant settings has increased, its activity on the earliest stages of human hematopoietic development remains poorly understood. Here, we have examined the ability of DLE to promote replenishment of functional lymphoid lineages from CD34(+) cells...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27744707/optimization-of-curcumin-loaded-peg-plga-nanoparticles-by-gsh-functionalization-investigation-of-the-internalization-pathway-in-neuronal-cells
#14
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using polylactic-co-glycolic acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However, the route of internalization of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterized glutathione-functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
January 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27617504/mutilating-squamous-cell-carcinoma-a-rare-complication-of-an-early-plaque-of-discoid-lupus-erythematosus
#15
S Kaur, P Sahu, S Dayal, V K Jain, N Jindal, V Jairath
Cutaneous Squamous cell carcinoma (SCC) is the second most common form of non-melanotic skin cancer after basal cell carcinoma (BCC). It is a well-known complication of discoid lupus erythematosus (DLE) and usually favours the depigmented lesions located over sun-exposed areas. The clinical course of this complication may be aggressive, with a high risk of mortality. Literature describes numerous case reports of SCC complicating the lesions of DLE but mutilating SCC is rarely mentioned. Here in, we report a rare case of mutilating squamous cell carcinoma arising in an early (two years duration) lesion of DLE...
February 22, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27610262/squamous-cell-cancer-arising-in-an-african-american-male-cheek-from-discoid-lupus-a-rare-case-and-review-of-the-literature
#16
Emanuel A Shapera, Paul D Kim
A 50-year-old African American male with Discoid Lupus Erythematosus (DLE) presented to the dermatology clinic for a rapidly enlarging left cheek mass. The mass failed to resolve with conservative measures. A biopsy revealed poorly differentiated Squamous Cell Carcinoma (SCC). He was referred to Head and Neck Surgery and successfully underwent a resection with free flap reconstruction. Postoperatively he did well. Squamous cell skin carcinomas arising from lesions of Discoid Lupus are rare and aggressive tumors with greater likelihood of metastases...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27557471/apoptosis-of-keratinocytes-and-serum-dnase-i-activity-in-patients-with-cutaneous-lupus-erythematosus-relationship-with-clinical-and-immunoserological-parameters
#17
D Skiljevic, B Bonaci-Nikolic, D Brasanac, M Nikolic
BACKGROUND: Dysregulation of apoptosis has an important role in the induction of autoimmunity. OBJECTIVE: To evaluate the influence of keratinocyte apoptosis and deoxyribonuclease I (DNase I) activity on the clinical and immunoserological parameters of cutaneous lupus erythematosus (CLE). METHODS: We studied 69 CLE patients (39 with discoid LE (DLE), 12 with subacute CLE (SCLE), 12 with acute and 6 with intermittent CLE). Thirty of sixty-nine patients fulfilled criteria for systemic LE (SLE)...
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27515950/cd8-t-cells-produce-a-dialyzable-antigen-specific-activator-of-dendritic-cells
#18
Ian A Myles, Ming Zhao, Glenn Nardone, Lisa R Olano, Jensen D Reckhow, Danial Saleem, Timothy J Break, Michail S Lionakis, Timothy G Myers, Paul J Gardina, Charles H Kirkpatrick, Steven M Holland, Sandip K Datta
Cellular lysates from PPD(+) donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by these reported phenomena, we found that the cellular extract derived from antigen-specific memory CD8(+) T cells induces IL-6 from antigen-matched APCs. This ultimately elicits IL-17 from bystander memory CD8(+) T cells...
January 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27431977/cutaneous-characteristics-and-association-with-antinuclear-antibodies-in-402-patients-with-different-subtypes-of-lupus-erythematosus
#19
N Patsinakidis, T Gambichler, N Lahner, K Moellenhoff, A Kreuter
BACKGROUND: Lupus erythematosus (LE) is an autoimmune disease characterized by a heterogeneous spectrum of skin manifestations and organ affection, and is frequently associated with serum autoantibodies, which mostly remain positive through the course of the disease. The classification of LE is still a controversial topic. OBJECTIVES: To examine the prevalence and long-term course of autoantibodies in patients with cutaneous LE (CLE) and/or systemic LE (SLE) treated in the outpatient clinic for connective tissue diseases of the department of Dermatology in Bochum, Germany...
December 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27310404/the-dichotic-digits-difference-test-dddt-development-normative-data-and-test-retest-reliability-studies-part-1
#20
Sharon Cameron, Helen Glyde, Harvey Dillon, Jessica Whitfield, John Seymour
BACKGROUND: The dichotic digits test is one of the most widely used assessment tools for central auditory processing disorder. However, questions remain concerning the impact of cognitive factors on test results. PURPOSE: To develop the Dichotic Digits difference Test (DDdT), an assessment tool that could differentiate children with cognitive deficits from children with genuine dichotic deficits based on differential test results. The DDdT consists of four subtests: dichotic free recall (FR), dichotic directed left ear (DLE), dichotic directed right ear (DRE), and diotic...
June 2016: Journal of the American Academy of Audiology
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