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Xiaohan Tian, Jie Zhang, Fan Zhang, Mengen Zhao, Zhenhua Chen, Kang Zhou, Peng Zhang, Xiuli Ren, Xiaoqian Jiang, Xifan Mei
N-(2-(3-fluorobenzyl)-2H-indazol-5-yl)-2-phenyl-2H-pyrazolo[4,3-c]qui- nolin-4-amine (LZC-2b) with a quinoline structure was synthesized as an anticancer prodrug. The pH sensitive anticancer drugs obtained by a simple hydrothermal method. The interaction of chitosan (Cts) and LZC-2b is used to complete the encapsulation without any cross-linking. The obtained micromedicine (LZC-2b@Cts-MSs) has an average size of ∼980 nm. The drug loading efficiency (DLE) of LZC-2b@Cts-MSs was about 79%. In addition, drug release from LZC-2b@Cts-MSs was pH depended...
February 24, 2018: Colloids and Surfaces. B, Biointerfaces
Rebecca L Bartles, James E Leggett, Shannan Hove, Catherine D Kashork, Lian Wang, Margret Oethinger, Lynda Baxter, Jack J Brandabur
BACKGROUND AND AIMS: In a pilot study (8) we demonstrated that current guidelines for duodenoscope and linear echoendoscope (DLE) reprocessing using a single cycle of high-level disinfection (HLD) in an automated reprocessor may be inadequate. In August 2015, the FDA offered double-HLD as a possible response to address this concern. As a result, Providence Health & Services adopted double-HLD as standard procedure for DLE, but no rigorous clinical studies supported this practice. We undertook a quality improvement (QI) study to compare single-HLD versus double-HLD at 4 of our 34 hospitals...
February 21, 2018: Gastrointestinal Endoscopy
Huan Huan Xie, Hui Shen, Li Zhang, Mei Ying Cui, Li Ping Xia, Jing Lu
We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria...
February 22, 2018: Scientific Reports
Heidi Igarashi, Michael R Levenson, Carolyn M Aldwin
Objectives: This study examined the development of wisdom within the context of difficult life events (DLEs), and the importance of individuals and their social environments in this process of growth. Social support has long been studied in adulthood, yet less is known about the ways social transactions can promote wisdom. Method: Semi-structured interviews were conducted with men (n = 14) and women (n = 36), ages 56-91 years (M = 71.71; SD = 8.8) who described a DLE and how they coped with it...
February 7, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
M P Acosta-Rios, E Sauer-Ramírez, L J Castro-Muñoz, M García-Solís, C Gómez-García, R Ocadiz-Delgado, A Martinez-Martinez, V Sánchez-Monroy, C Pérez-De la Mora, B Correa-Meza, D G Perez-Ishiwara
The objective of the study was to assess the clinical, histopathological and immunochemical changes induced by dialyzable leukocyte extract (DLE) treatment in patients with chronic cervicitis associated to HPV infection. Fifty-four female Mexican patients diagnosed with chronic cervicitis, cervical intra-epithelial neoplasia grade 1 (CIN 1) and HPV infection were divided into two groups: patients treated with placebo and patients treated with DLE. Clinical and colposcopy evaluations were performed before and after treatments...
October 2017: Journal of Medicine and Life
Hsing-Jou Su, An-Yu Cheng, Cheng-Han Liu, Chia-Bau Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. In this retrospective case series, we reviewed 89 patients with pathology-confirmed PSA. The data was collected from National Cheng Kung University Hospital between 1988 through 2016. The clinical and histological data were reviewed, and the patients were characterized into different subtypes of PSA based on the clinical features and histological findings...
January 16, 2018: Journal of Dermatology
J K Presto, L G Okon, R Feng, D J Wallace, R Furie, D Fiorentino, V P Werth
BACKGROUND: R333 is a topical janus kinase and spleen tyrosine kinase inhibitor being evaluated for discoid lupus erythematosus (DLE) treatment. There is no validated measure to assess area of active DLE lesions. OBJECTIVES: To evaluate R333 efficacy and assess a technique to measure responsiveness. METHODS: 54 DLE patients were randomized in a double blind design to R333 or placebo. The primary endpoint was the proportion of patients achieving ≥50% decrease in erythema and scale based on lesional CLASI for all treated lesions at week 4...
January 16, 2018: British Journal of Dermatology
Jason F Wang, Andrew J Park, Tina Rendini, William R Levis
<p>Lawrence transfer factor (TF) is defned as dialyzable leukocyte extract (DLE) that can transfer antigen-specifc cell-mediated immunity from a person testing positive for the antigen in a delayed type hypersensitivity skin test manner to a person negative for the same antigen.</p> <p>A recent article by Myles et al1 has identifed a DLE isolated from an established CD8+ T cell line capable of transferring antigen-specifc immunity. The DLE contains a portion of the beta chain of the T cell receptor and additional nucleotide and protein factors that are being subjected to further modern biochemical analysis...
December 1, 2017: Journal of Drugs in Dermatology: JDD
Balachandra S Ankad, Swapnil D Shah, Keshavmurthy A Adya
White rosettes are shiny white structures seen as four oval-shaped points that come together in the center. They resemble four-leaf clover [1]. Earlier it was thought they were specific for actinic keratosis and squamous cell carcinoma, but they are noted in many other conditions [2]. With polarized light dermoscopy, it is evident that rosettes are seen only and they are due to the optical effect between polarized light and follicular structures [3]. Here, authors describe cases of discoid lupus erythematosus (DLE) demonstrating rosettes under polarized dermoscopy...
October 2017: Dermatology Practical & Conceptual
Jessica Cervantes, Farhaan Hafeez, Mariya Miteva
Dermoscopic features of discoid lupus erythematosus (DLE) depend on the stage of the lesions: active lesions include yellow-brown dots and red dots, whereas longstanding inactive lesions show absence of follicular openings, cicatricial milky red or white patches, structureless white and brown areas, and thick arborizing vessels. Loss of pinpoint white dots, blue-gray dots in a speckled pattern, and a peripheral pigmented network have been described on dermoscopy of DLE in dark skin. We report a blue-white veil as a novel dermoscopic feature in 2 cases of biopsy-proven DLE in African-American patients...
October 2017: Skin Appendage Disorders
Parul Verma, Sucheta Pathania, Asha Kubba
Discoidlupus erythematosus (DLE) is a chronic type of cutaneous lupus erythematosus which can present in various morphologies, and the diagnosis can be rather confounding. Prompt evaluation and treatment is necessary to prevent disfigurement and systemic involvement associated with DLE. The following case presented a diagnostic dilemma as the lesion mimicked lupus vulgaris.
November 8, 2017: BMJ Case Reports
Beatriz Eugenia Fuentes-Castro, Juan Gerardo Reyes-García, María Teresa Valenzuela-Vargas, Federico Martínez-Gómez
BACKGROUND: Dialyzable leukocyte extracts (DLEs) contain molecules smaller than 10 kDa with biological activity in receptor organisms. Primarily, they participate in the regulation of the Th1 immune response, which is essential for the control of several intracellular infections, such as toxoplasmosis. This disease is associated with congenital infection, encephalitis or systemic infections in immunocompromised individuals. The clinical course of this infection fundamentally depends on a well-regulated immune response and timely treatment with the appropriate drugs...
November 2017: Memórias do Instituto Oswaldo Cruz
Andreas Zaucker, Agnieszka Nagorska, Pooja Kumari, Nikolai Hecker, Yin Wang, Sizhou Huang, Ledean Cooper, Lavanya Sivashanmugam, Shruthi VijayKumar, Jan Brosens, Jan Gorodkin, Karuna Sampath
In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational co-regulation of multiple components of a developmental signaling pathway. Here, we show that an RNA element which we previously identified as a dorsal localization element (DLE) in the 3'UTR of zebrafish nodal-related1/squint (ndr1/sqt) ligand mRNA, is shared by the related ligand nodal-related2/cyclops (ndr2/cyc) and the nodal inhibitors, lefty1 (lft1) and lefty2 mRNAs...
October 20, 2017: Nucleic Acids Research
Ioanna-Eirini Arvanitidou, Nikolaos G Nikitakis, Maria Georgaki, Nick Papadogeorgakis, Athanasios Tzioufas, Alexandra Sklavounou
Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. A 40-year-old female with a 24-year history of DLE with peri- and intraoral involvement initially developed SCC of the vermillion border of the right lower lip; the lesion was surgically removed and did not recur within 6 months...
August 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Eric Stallard, Bruce Kinosian, Yaakov Stern
BACKGROUND: Alzheimer's disease (AD) progression varies substantially among patients, hindering calculation of residual total life expectancy (TLE) and its decomposition into disability-free life expectancy (DFLE) and disabled life expectancy (DLE) for individual patients with AD. The objective of the present study was to assess the accuracy of a new synthesis of Sullivan's life table (SLT) and longitudinal Grade of Membership (L-GoM) models that estimates individualized TLEs, DFLEs, and DLEs for patients with AD...
September 20, 2017: Alzheimer's Research & Therapy
Abbas Darjani, Rana Rafiei, Alireza Mesbah, Razieh Golmohammadi, Behnam Rafiee, Mehriar Movaseghi
Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas of head and neck. Infrequently it could be presented by palpebral involvement and rarely unilateral upper eye lid edema and erythema have been reported as the sole manifestation of DLE. We describe a 38-year-old woman with chronic left upper eye lid edema and erythema from one year ago which was induced by steroid injection for left eyebrow alopecia. Histopathologic and direct immunofluorescent studies were made on palpebral skin tissue and confirmed DLE diagnosis...
July 2017: Acta Medica Iranica
Weiguo Xu, Jianxun Ding, Xuesi Chen
Reduction-responsive methoxy poly(ethylene glycol)-block-poly(S-tert-butylmercapto-L-cysteine) copolymers (i.e., mPEG113-b-PBMLC4 and mPEG113-b-PBMLC9) were facilely synthesized through primary amino-initiated ring-opening polymerization (ROP) of disulfide-containing N-carboxyanhydride monomer. The reduction-responsive block copolymers were then investigated for intracellular delivery of antitumor drug after forming smart micelles in vitro and in vivo. The micelles were denoted as P4M and P9M, respectively...
September 15, 2017: Biomacromolecules
Ashish Chhaganlal Gandhi, Sheng Yun Wu
Nickel oxide is one of the highly promising semiconducting materials, but its large band gap (3.7 to 4 eV) limits its use in practical applications. Here we report the effect of nickel/oxygen vacancies and interstitial defects on the near-band-edge (NBE) and deep-level-emission (DLE) in various sizes of nickel oxide (NiO) nanoparticles. The ultraviolet (UV) emission originated from excitonic recombination corresponding near-band-edge (NBE) transition of NiO, while deep-level-emission (DLE) in the visible region due to various structural defects such as oxygen vacancies and interstitial defects...
August 22, 2017: Nanomaterials
Katarzyna Skonieczna, Rafał Czajkowski, Sebastian Kaszewski, Mariusz Gawrych, Aneta Jakubowska, Tomasz Grzybowski
INTRODUCTION: Many studies have shown that some SNPs might be a risk factor for systemic lupus erythematosus (SLE), but little is known about potential susceptibility loci of the skin types of the disease. Discoid lupus erythematosus (DLE) is the most common form of the cutaneous lupus erythematosus. Nevertheless, a genetic contribution to DLE is not fully recognized. AIM: We aimed to analyze three SNPs located in the STAT4 (rs7574865), ITGAM (rs1143679) and TNXB (rs1150754) genes in both DLE and SLE patients from Poland...
June 2017: Postȩpy Dermatologii i Alergologii
Mazaher Ramezani, Bita-Sadat Hashemi, Sedigheh Khazaei, Mansour Rezaei, Ali Ebrahimi, Masoud Sadeghi
BACKGROUND: Cluster of differentiation (CD) markers is a classification system for monoclonal antibodies against cell surface molecules on leukocytes and antigens from other cells. AIMS: The aim of this study is to evaluate immunohistochemical markers in patients with discoid lupus erythematosus (DLE) and lichen planus (LP) and correlation of these markers in two groups and with the normal group in the West of Iran. SETTINGS AND DESIGN: Analytical cross-sectional study...
April 2017: Indian Journal of Pathology & Microbiology
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