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https://www.readbyqxmd.com/read/29236346/therapy-related-acute-myeloid-leukaemia-and-myelodysplastic-syndrome-in-victoria-australia-2003-2014
#1
Doen Ming Ong, Helen Farrugia, Andrew Wei
BACKGROUND: The burden of therapy-related acute myeloid leukaemia (tAML) / therapy-related myelodysplastic syndrome (tMDS) in Australia has not been characterized. METHODS: We analysed adults aged ≥20 years at diagnosis of acute myeloid leukaemia (AML) / myelodysplastic syndrome (MDS) reported to the Victorian Cancer Registry (VCR) between 2003-2014. RESULTS: 73/3,120 (2.3%) AML cases were classified tAML. tAML patients were younger than non-tAML patients at diagnosis (median age 66 vs...
December 13, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29235937/the-impact-of-genetically-modified-gm-crops-in-modern-agriculture-a-review
#2
Ruchir Raman
Genetic modification in plants was first recorded 10,000 years ago in Southwest Asia where humans first bred plants through artificial selection and selective breeding. Since then, advancements in agriculture science and technology have brought about the current GM crop revolution. GM crops are promising to mitigate current and future problems in commercial agriculture, with proven case studies in Indian cotton and Australian canola. However, controversial studies such as the Monarch Butterfly study (1999) and the Séralini affair (2012) along with current problems linked to insect resistance and potential health risks have jeopardised its standing with the public and policymakers, even leading to full and partial bans in certain countries...
December 13, 2017: GM Crops & Food
https://www.readbyqxmd.com/read/29235448/how-do-the-reference-montage-and-electrodes-setup-affect-the-measured-scalp-eeg-potentials
#3
Shiang Hu, Yongxiu Lai, Pedro Antonio Valdés-Sosa, Maria Luisa Brings-Vega, Dezhong Yao
OBJECTIVE: Human scalp electroencephalogram (EEG) is widely applied in cognitive neuroscience and clinical studies due to its non-invasiveness and ultra-high time resolution. However, the representativeness of the measured EEG potentials for the underneath neural activities is still a problem under debate. This study aims to investigate systematically how both reference montage and electrodes setup affect the accuracy of EEG potentials. APPROACH: First, the standard EEG potentials are generated by the forward calculation with a single dipole in the neural source space, for eleven channel numbers (10, 16, 21, 32, 64, 85, 96, 128, 129, 257, 335)...
December 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29235364/patient-reported-safety-incidents-as-a-new-source-of-patient-safety-data-an-exploratory-comparative-study-in-an-acute-hospital-in-england
#4
Gerry Armitage, Sally Moore, Caroline Reynolds, Pierre-Antoine Laloë, Claire Coulson, Rosie McEachan, Rebecca Lawton, Ian Watt, John Wright, Jane O'Hara
Objectives To compare a new co-designed, patient incident reporting tool with three established methods of detecting patient safety incidents and identify if the same incidents are recorded across methods. Method Trained research staff collected data from inpatients in nine wards in one university teaching hospital during their stay. Those classified as patient safety incidents were retained. We then searched for patient safety incidents in the corresponding patient case notes, staff incident reports and reports to the Patient Advice and Liaison Service specific to the study wards...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29235252/closure-of-the-cystic-duct-orifice-in-laparoscopic-subtotal-cholecystectomy-for-severe-cholecystitis
#5
Tatsuki Matsumura, Shunichiro Komatsu, Kenichi Komaya, Keiichi Ando, Takashi Arikawa, Seiji Ishiguro, Takuya Saito, Takaaki Osawa, Shintaro Kurahashi, Tairin Uchino, Kohei Yasui, Shoko Kato, Kenta Suzuki, Yoko Kato, Tsuyoshi Sano
INTRODUCTION: Laparoscopic subtotal cholecystectomy (LSC) has been recognized as an alternative to conversion to laparotomy for severe cholecystitis. However, it may be associated with an increased risk of recurrent stones in the gallbladder remnant. The objective of this study was to evaluate the safety and feasibility of the complete removal of the gallbladder cavity in LSC for severe cholecystitis using the cystic duct orifice suturing (CDOS) technique. METHODS: In a consecutive series of 412 laparoscopic cholecystectomies that were performed from January 2015 to June 2017, 12 patients who underwent LSC with CDOS were enrolled in this retrospective study...
December 13, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29235239/familial-risks-in-urolithiasis-in-the-population-of-sweden
#6
Kari Hemminki, Otto Hemminki, Asta Försti, Kristina Sundquist, Jan Sundquist, Xinjun Li
OBJECTIVES: To assess detailed familial risks for medically diagnosed urolithiasis (UL, urinary tract stone disease) based on nationwide hospital and population records. SUBJECTS/PATIENTS AND METHODS: Subjects were identified from the Swedish Multigeneration Register in which 211,718 UL patients. Standardized incidence ratios (SIRs) were calculated by comparison to individuals without a family history of UL. RESULTS: The highest familial SIRs were invariably found for the same (concordant) type of UL: 2...
December 13, 2017: BJU International
https://www.readbyqxmd.com/read/29235170/scaling-up-integrated-early-childhood-development-programs-lessons-from-four-countries
#7
R Pérez-Escamilla, V Cavallera, M Tomlinson, T Dua
BACKGROUND: There is still limited knowledge regarding the translation of early child development (ECD) knowledge into effective policies and large-scale programmes. A variety of frameworks that outline the key steps in scaling up exist, but we argue that taking a complex adaptive systems (CAS) approach assists in understanding the complex, dynamic processes that result in programmes being taken to scale. OBJECTIVES: The objective of this study is to examine the process of scaling up four major country-level ECD programmes through the application of a CAS framework...
January 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29234923/non-inferiority-multicenter-prospective-randomized-controlled-study-of-rectal-cancer-t2-t3s-superficial-n0-m0-undergoing-neoadjuvant-treatment-and-local-excision-tem-vs-total-mesorectal-excision-tme
#8
X Serra-Aracil, C Pericay, T Golda, L Mora, E Targarona, S Delgado, A Reina, F Vallribera, J M Enriquez-Navascues, S Serra-Pla, J C Garcia-Pacheco
PURPOSE: The standard treatment of rectal adenocarcinoma is total mesorectal excision (TME), in many cases requires a temporary or permanent stoma. TME is associated with high morbidity and genitourinary alterations. Transanal endoscopic microsurgery (TEM) allows access to tumors up to 20 cm from the anal verge, achieves minimal postoperative morbidity and mortality rates, and does not require an ostomy. The treatment of T2, N0, and M0 cancers remains controversial. Preoperative chemoradiotherapy (CRT) in association with TEM reduces local recurrence and increases survival...
December 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29234842/-patients-with-a-wearable-cardioverter-defibrillator-wcd-prescription-function-and-rehabilitation-support
#9
REVIEW
A Schlitt, M Guha, M Noutsias, H H Klein, H U Klein
Assessment of a permanent risk of life-threatening ventricular arrhythmia in patients with severely reduced left ventricular ejection fraction (LVEF <35%), e. g. after myocarditis, dilated cardiomyopathy, acute myocardial infarction, in patients with postpartum cardiomyopathy or implantable cardioverter-defibrillator (ICD) and cardiac resynchronization treatment plus defibrillator (CRT-D) infection with temporary explantation of the system is a medical challenge. This is time-consuming and unsafe because life-threatening ventricular arrhythmias may occur during the time of risk assessment...
December 12, 2017: Herz
https://www.readbyqxmd.com/read/29234838/clinical-characteristics-and-prognosis-of-traumatic-head-injury-following-road-traffic-accidents-admitted-in-icu-analysis-of-694-cases
#10
Hedi Chelly, Mabrouk Bahloul, Rania Ammar, Ahmed Dhouib, Khaireddine Ben Mahfoudh, Mohamed Zaher Boudawara, Olfa Chakroun, Imen Chabchoub, Anis Chaari, Mounir Bouaziz
BACKGROUND: The aim of the present study is to analyze the clinical and epidemiological characteristics of Traumatic Brain Injury (TBI) following Road Traffic Accidents (RTAs). Moreover, we aim to evaluate the outcome of the TBI victims referred to our medico-surgical Intensive Care Unit (ICU), and to define predictive factors associated with poor prognosis. METHODS: A retrospective study over a 4-year period (2009 to 2012) of 694 patients with head injuries, incurred during road traffic accidents, admitted to the Intensive Care Unit (ICU) of a university hospital (Sfax-Tunisia)...
December 12, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29234656/amputation-risk-after-the-revascularization-procedures-in-sarcoma-resections
#11
Luiz Eduardo Moreira Teixeira, Thiago Marques Leão, Daniel Barbosa Regazzi, Cláudio Beling Gonçalves Soares
Objective: The objective of this study is to evaluate the efficacy of vascular reconstructive surgery after resection of bone and soft tissue tumors in extremities and the risk of progression to amputation. Methods: This is a retrospective, observational data collection from medical records of patients who underwent resection of bone and soft tissue tumors in the period of 2002-2015. Thirteen patients met the inclusion criteria, which evaluated the correlations between certain factors (gender, tumor type, location, reconstruction, revascularization and patency, infection) with amputation in the postoperative period...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234609/outcomes-of-open-repair-of-mycotic-aortic-aneurysms-with-in-situ-replacement
#12
Hyo-Hyun Kim, Do Jung Kim, Hyun-Chel Joo
Background: Mycotic aortic aneurysms are rare and life-threatening. Unfortunately, no established guidelines exist for the treatment of patients with mycotic aortic aneurysms. The purpose of this study was to evaluate the midterm outcomes of the open repair of mycotic thoracic and thoracoabdominal aneurysms and suggest a therapeutic strategy. Methods: From 2006 to 2016, 19 patients underwent open repair for an aortic aneurysm. All infected tissue was extensively debrided and covered with soft tissue...
December 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29234603/a-retrospective-study-of-clinico-epidemiological-profile-of-snakebite-related-deaths-at-a-tertiary-care-hospital-in-midnapore-west-bengal-india
#13
Rituparna Ghosh, Koushik Mana, Kripasindhu Gantait, Sumana Sarkhel
Objective: Snakebite is one of the neglected tropical diseases that World Health Organization (WHO) aimed to eradicate. The objective of the study is to investigate the mortality and morbidity due to snakebite at Midnapore Medical College & Hospital in Paschim Medinipur district, West Bengal, India. Methods & materials: This is a record-based, retrospective, descriptive epidemiological study conducted from January 2012 to December 2016 at Midnapore Medical College and Hospital(MMCH), Paschim Medinipur district, West Bengal...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29234379/the-instrument-for-measuring-the-implementation-situation-of-traditional-chinese-medicine-guideline-evaluation-and-application
#14
Hui Li, Yangyang Wang, Yaolong Chen, Xiaoyun Wang, Chuanjian Lu, Jingwen Deng
Clinical practice guidelines play an important role in reducing the variations in clinical practices and improving the quality of care. To assess the real effect, measuring its implementation situation is needed. The implementation situation can be reflected by testing the consistency between the actual clinical practice and the guideline. We constructed an instrument to measure the implementation situation of Traditional Chinese Medicine (TCM) guideline through consistency testing. The main objectives of our study were to validate the instrument and evaluate the implementation situation of menopause syndrome guideline of TCM, using the data from the consistency test of comparing the medical records with the guideline...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234095/enclaves-of-genetic-diversity-resisted-inca-impacts-on-population-history
#15
Chiara Barbieri, José R Sandoval, Jairo Valqui, Aviva Shimelman, Stefan Ziemendorff, Roland Schröder, Maria Geppert, Lutz Roewer, Russell Gray, Mark Stoneking, Ricardo Fujita, Paul Heggarty
The Inca Empire is claimed to have driven massive population movements in western South America, and to have spread Quechua, the most widely-spoken language family of the indigenous Americas. A test-case is the Chachapoyas region of northern Peru, reported as a focal point of Inca population displacements. Chachapoyas also spans the environmental, cultural and demographic divides between Amazonia and the Andes, and stands along the lowest-altitude corridor from the rainforest to the Pacific coast. Following a sampling strategy informed by linguistic data, we collected 119 samples, analysed for full mtDNA genomes and Y-chromosome STRs...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233952/epidemiological-study-of-mortality-rate-from-alcohol-and-illicit-drug-abuse-in-iran
#16
Seyed Mohammad Sadegh Ghoreishi, Fatemeh Shahbazi, Seyed Davood Mirtorabi, Mohammad Reza Ghadirzadeh, Seyed Saeed Hashemi Nazari
BACKGROUND: The estimate of mortality associated with illicit opiate use provides useful information to those directing and monitoring local, national and international policies and programs. This study investigated the epidemiology of mortality due to the illegal consumption of narcotics and psychotropic substances in the Iran to provide evidence-based public health data for useful programs and actions aimed at preventing drug-related mortality. STUDY DESIGN: A cross-sectional study...
October 14, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29233748/rationale-behind-the-use-of-double-layer-poly-propylene-patch-g-patch-dural-substitute-during-decompressive-craniectomy-as-an-adhesion-preventive-material-for-subsequent-cranioplasty-with-special-reference-to-flap-elevation-time
#17
Milesh Nagar, Rosebist Pk, Raj Chandran, Sharmad Ms, Rajmohan Bp, Anil Peethambaran, Sreejith Md, Sourabh Jain, Saurabh Sharma
OBJECTIVE: Dural substitutes are used in decompressive craniectomy (DC) in order to prevent adhesions during subsequent cranioplasty. Current literature attributes them to the reduced blood loss and reduction in operative time of cranioplasty. The use of double layer substitute has rarely been documented. We decided to study the use of double layer G-patch as a dural substitute in DC and evaluate its outcome during subsequent cranioplasty with special focus on flap elevation time and blood loss during cranioplasty...
December 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29233697/retrospective-analysis-of-471-surgically-treated-zygomaticomaxillary-complex-fractures
#18
Michael Blumer, Sabina Kumalic, Thomas Gander, Martin Lanzer, Claudio Rostetter, Martin Rücker, Heinz-Theo Lübbers
PURPOSE: Zygomaticomaxillary complex (ZMC) fractures are frequent in facial trauma; only fractures of the mandible are more common. Although the frequency of these fractures is geographically consistent, the aetiology differs widely among countries and even regions. Differences in socio-economic status and the ageing population seem to be two causes. This retrospective epidemiological study evaluates patients who were surgically treated for ZMC fractures at a Swiss university clinic. MATERIALS AND METHODS: This study included 471 patients who were surgically treated for ZMC fractures in an oral and maxillofacial surgery clinic at a Swiss university hospital between January 2004 and December 2012...
November 23, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233685/contrast-enhanced-ultrasound-in-mixed-hepatocellular-cholangiocarcinoma-case-series-and-review-of-the-literature
#19
Yi Dong, Andreas Teufel, Jörg Trojan, Annalisa Berzigotti, Xin Wu Cui, Christoph F Dietrich
BACKGROUND: Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. AIMS: The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. METHODS: Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis...
November 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29233628/xanthogranulomatous-pyelonephritis-in-a-paediatric-cohort-1963-2016-outcomes-from-a-large-single-center-series
#20
I Stoica, F O'Kelly, M B McDermott, F M J Quinn
BACKGROUND: Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney. It was first described in 1916, and is thought to affect 6/1000 cases of pyelonephritis. Its manifestations are varied, and with a limited number of cases in the literature, the optimal diagnosis and management of XGP in the paediatric cohort is still unknown. MATERIAL AND METHODS: The medical records of children who were diagnosed and treated for XGP at the current unit during the period 1963-2016, inclusive, were retrospectively reviewed...
November 24, 2017: Journal of Pediatric Urology
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