keyword
https://read.qxmd.com/read/38497348/oral-epithelial-dysplasia-with-lymphocytic-immune-response-clinicopathological-characterisation-of-44-cases
#21
JOURNAL ARTICLE
Ivan J Stojanov, Joud Omari, Ibrahim Akeel, Ahmed S Sultan, Sook-Bin Woo
AIMS: Oral epithelial dysplasia (OED) often exhibits a lymphocytic/lichenoid immune response (LIR), imparting histological resemblance to lichenoid mucositis and rendering diagnosis challenging. The clinical appearances of OED and lichenoid inflammatory processes are generally divergent, presenting as well-demarcated hyperkeratotic plaques and diffuse white and/or red mucosal change with variably prominent Wickham striae, respectively. To date, clinicopathological characterisation of OED with LIR, including clinical/gross appearance, has not been depicted...
March 18, 2024: Histopathology
https://read.qxmd.com/read/38496540/brain-wide-neuronal-circuit-connectome-of-human-glioblastoma
#22
Yusha Sun, Xin Wang, Daniel Y Zhang, Zhijian Zhang, Janardhan P Bhattarai, Yingqi Wang, Weifan Dong, Feng Zhang, Kristen H Park, Jamie Galanaugh, Abhijeet Sambangi, Qian Yang, Sang Hoon Kim, Garrett Wheeler, Tiago Goncalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Huadong Wang, Fuqiang Xu, Zev A Binder, Isaac H Chen, Emily Ling-Lin Pai, Sara Stone, MacLean Nasrallah, Kimberly M Christian, Marc Fuccillo, Donald M O'Rourke, Minghong Ma, Guo-Li Ming, Hongjun Song
Glioblastoma (GBM), a universally fatal brain cancer, infiltrates the brain and can be synaptically innervated by neurons, which drives tumor progression 1-6 . Synaptic inputs onto GBM cells identified so far are largely short-range and glutamatergic 7-9 . The extent of integration of GBM cells into brain-wide neuronal circuitry is not well understood. Here we applied a rabies virus-mediated retrograde monosynaptic tracing approach 10-12 to systematically investigate circuit integration of human GBM organoids transplanted into adult mice...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38496529/a-prospective-cohort-study-exploring-the-joint-influence-of-sunlight-exposure-and-tanning-bed-use-on-basal-cell-carcinoma-squamous-cell-carcinoma-and-melanoma-risk
#23
Megan M Tran, Elisabeth A George-Washburn, Jongeun Rhee, Wen-Qing Li, Abrar Qureshi, Eunyoung Cho
Exposure to solar ultraviolet (UV) radiation and use of UV-emitting tanning devices are known risk factors for skin cancer. Few studies have explored the interaction between these risk factors, namely how the risk of skin cancer increases among those who both have been exposed to high levels of natural sunlight and regularly use tanning beds. Nurses' Health Study II followed 116,430 women, aged 25-42, from 1991 to 2011. Cumulative average UV exposure was based on participants' residences at follow-up periods...
March 6, 2024: Research Square
https://read.qxmd.com/read/38496182/low-powered-view-high-powered-mind-a-case-report-of-morpheaform-basal-cell-carcinoma-mistaken-for-metastatic-breast-carcinoma
#24
Riley K Imlay, Cristhian Perez Torrico, Abdullahi Sulaimann, Zachary M Grimes, Shane Monnett
Basal cell carcinoma (BCC) is one of the most common skin malignancies worldwide. Morpheaform basal cell carcinoma (MBCC) is a rare aggressive subtype of BCC that presents with unique histologic features. Both are treated surgically and have an excellent survival rate. Metastatic breast carcinoma, on the other hand, has a poor survival rate along with a more burdensome therapeutic route including chemotherapy. Due to an overlap in common immunohistochemistry stains, there is a possibility of confusing the diagnosis of BCC with metastatic breast carcinoma resulting in potential patient harm...
February 2024: Curēus
https://read.qxmd.com/read/38495115/a-randomized-trial-of-a-wearable-uv-dosimeter-for-skin-cancer-prevention
#25
JOURNAL ARTICLE
Emmanuel L P Dumont, Peter D Kaplan, Catherine Do, Shayak Banerjee, Melissa Barrer, Khaled Ezzedine, Jonathan H Zippin, George I Varghese
BACKGROUND: Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the United States. Despite guidelines on ultraviolet (UV) avoidance, it remains difficult for people to assess their exposure, as UV is invisible and the onset of UV-induced symptoms is delayed. METHODS: In a prospective randomized trial, 97 elderly patients with a history of actinic keratoses (AK) were followed over 6 months. Fifty patients received UV counseling from a dermatologist and a wearable UV dosimeter that provided real-time and cumulative UV exposure...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38491910/activation-of-bivalent-gene-pou4f1-promotes-and-maintains-basal-like-breast-cancer
#26
JOURNAL ARTICLE
Jiahui Zhang, Nanyan Miao, Liyan Lao, Wen Deng, Jiawen Wang, Xiaofeng Zhu, Yongsheng Huang, Huayue Lin, Wenfeng Zeng, Wei Zhang, Luyuan Tan, Xiaoqing Yuan, Xin Zeng, Jingkun Zhu, Xueman Chen, Erwei Song, Linbin Yang, Yan Nie, Di Huang
Basal-like breast cancer (BLBC) is the most aggressive molecular subtype of breast cancer with worse prognosis and fewer treatment options. The underlying mechanisms upon BLBC transcriptional dysregulation and its upstream transcription factors (TFs) remain unclear. Here, among the hyperactive candidate TFs of BLBC identified by bioinformatic analysis, POU4F1 is uniquely upregulated in BLBC and is associated with poor prognosis. POU4F1 is necessary for the tumor growth and malignant phenotypes of BLBC through regulating G1/S transition by direct binding at the promoter of CDK2 and CCND1...
March 16, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38486239/production-characterization-and-biomedical-potential-of-biosurfactants-produced-by-haloalkaliphilic-archaea-from-wadi-el-natrun-egypt
#27
JOURNAL ARTICLE
Basma T Alghamrawy, Ghada E Hegazy, Soraya A Sabry, Hanan Ghozlan
Extreme halophilic archaea that can live in high saline environments can offer potential applications in different biotechnological fields. This study delves into the fascinating field of halophilic archaea and their ability to produce biosurfactants. Some strains of haloarchaea were isolated from Wadi El-Natrun and were screened for biosurfactants production in a standard basal medium using emulsification index assay. Two strains were chosen as the potential strains for surface tension reduction. They were identified as Natrialba sp...
March 14, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38486210/spectrum-of-malignant-and-premalignant-skin-lesions-in-505-adult-subjects-at-risk-of-skin-cancers
#28
JOURNAL ARTICLE
Reetta Nevakivi, Hanna Siiskonen, Salla Haimakainen, Ilkka T Harvima
Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 adult subjects (aged 21-79 years, 256 males and 249 females, 96 with immunosuppression) at risk of any type of skin cancer were examined for cutaneous malignancies, nevi, actinic keratoses, photodamage, and possible risk factors...
March 14, 2024: BMC Cancer
https://read.qxmd.com/read/38485766/lamin-b1-curtails-early-human-papillomavirus-infection-by-safeguarding-nuclear-compartmentalization-and-autophagic-capacity
#29
JOURNAL ARTICLE
Freya Molenberghs, Marlies Verschuuren, Lauran Vandeweyer, Sarah Peeters, Johannes J Bogers, Claudina Perez Novo, Wim Vanden Berghe, Hans De Reu, Nathalie Cools, Mario Schelhaas, Winnok H De Vos
Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes lacking the major lamins with a HPV16 pseudovirus (HP-PsV) encoding an EGFP reporter. We found that a sustained reduction or complete loss of lamin B1 significantly increased HP-PsV infection rate...
March 14, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38484209/comprehensive-analysis-identifies-variability-in-pi3k-pathway-alterations-in-triple-negative-breast-cancer-subtypes
#30
JOURNAL ARTICLE
Reva K Basho, Li Zhao, Jason B White, Lei Huo, Roland L Bassett, Elizabeth A Mittendorf, Alastair Thompson, Jennifer K Litton, Naoto Ueno, Banu Arun, Bora Lim, Vicente Valero, Debu Tripathy, Jianhua Zhang, Beatriz E Adrada, Lumarie Santiago, Elizabeth Ravenberg, Sahil Seth, Clinton Yam, Stacy L Moulder, Senthil Damodaran
PURPOSE: The PI3K pathway is frequently altered in triple-negative breast cancer (TNBC). Limited cell line and human data suggest that TNBC tumors characterized as mesenchymal (M) and luminal androgen receptor (LAR) subtypes have increased incidence of alterations in the PI3K pathway. The impact of PI3K pathway alterations across TNBC subtypes is poorly understood. METHODS: Pretreatment tumor was evaluated from operable TNBC patients enrolled on a clinical trial of neoadjuvant therapy (NAT; A Robust TNBC Evaluation fraMework to Improve Survival [ClinicalTrials...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38483049/hydrochlorothiazide-and-increased-risk-of-atypical-fibroxanthoma-and-pleomorphic-dermal-sarcoma
#31
JOURNAL ARTICLE
Thomas Kuntz, Alexander Grimm, Silke C Hofmann, Alena-Lioba Michalowitz, Jörg Schaller, Martin Hellmich, Chalid Assaf, Frank Oellig, Alexander Kreuter
BACKGROUND AND OBJECTIVES: Previous work has demonstrated that hydrochlorothiazide (HCTZ) is a risk factor for squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) due to pro-photocarcinogenic effects. Atypical fibroxanthoma (AFX) and pleomorphic sarcoma (PDS), both ultraviolet-induced cancers, display a rare but rising cutaneous tumor entity. This study aimed to evaluate if the use of HCTZ is higher in patients with AFX/PDS than in patients with SCC/BCC and subsequently may be a risk factor for AFX/PDS-development...
March 14, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
https://read.qxmd.com/read/38481907/discrepancies-in-non-mohs-micrographic-surgery-for-non-melanoma-skin-cancer-between-lighter-skinned-and-darker-skinned-patients
#32
JOURNAL ARTICLE
Luis J Borda, Iain Noel M Encarnacion, Ryan C Saal, H William Higgins Ii, Robert J Pariser
BACKGROUND: Non-melanoma skin cancer (NMSC) is highly prevalent in the United States, with darker-skinned patients (DSP) exhibiting lower incidence but increased morbidity and mortality. The purpose of this study is to elucidate NMSC disparities between DSP (Fitzpatrick skin phototype IV or more) and lighter-skinned patients (LSP, Fitzpatrick skin phototype III or less), focusing on surgical features of non-Mohs micrographic surgery-treated NMSC. METHODS: This retrospective cohort study included LSP and DSP diagnosed with either basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) in an academic dermatology setting...
February 2024: Curēus
https://read.qxmd.com/read/38481563/repair-of-a-large-nasal-ala-and-medial-cheek-defect-case-report
#33
Hannah E Myers, Ashley A Kessler, Michael Roberts, Christopher Buckley
INTRODUCTION: Mohs micrographic surgery is a complex but essential aspect of functional and cosmetic skin cancer removal. It allows for skin cancers to be removed from cosmetically challenging areas in the most efficient and effective possible method; however, closure of these lesions can be difficult. CASE: An 80-year-old male presented for Mohs surgery of a basal cell carcinoma on the right nasal sidewall that measured 3.4 cm. The patient underwent seven stages of Mohs surgery, and the final defect measured 6...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38481562/management-of-locally-advanced-basal-cell-carcinoma-with-sonic-hedgehog-pathway-targeted-therapy-a-case-report-and-discussion
#34
Neal Ferrin, Darwin Edmond, Ryan Jones, Laurence E McCahill
INTRODUCTION: Basal cell carcinoma (BCC) is the most common skin malignancy in the world. While most lesions are treated using surgical methods, others may present as locally advanced or metastatic disease and are not amenable to surgical therapy alone. Treatment with sonic hedgehog pathway inhibitors (vismodegib, sonidegib) is designed to inhibit key signaling proteins and gene pathways involved with BCC to reduce the uncontrolled proliferation of basal cells in complicated disease and can be invaluable in treating patients with advanced disease...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38481282/tp63-trim29-axis-regulates-enhancer-methylation-and-chromosomal-instability-in-prostate-cancer
#35
JOURNAL ARTICLE
R Sultanov, A Mulyukina, O Zubkova, A Fedoseeva, A Bogomazova, K Klimina, A Larin, T Zatsepin, T Prikazchikova, M Lukina, M Bogomiakova, E Sharova, E Generozov, M Lagarkova, G Arapidi
BACKGROUND: Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high rate of large genomic rearrangements are often observed in PRAD. RESULTS: To investigate the reasons for such high variance, we integrated DNA methylation, RNA-seq, and copy number alterations datasets from The Cancer Genome Atlas (TCGA), focusing on PRAD, and employed weighted gene co-expression network analysis (WGCNA)...
March 14, 2024: Epigenetics & Chromatin
https://read.qxmd.com/read/38480932/basal-epithelial-subpopulations-underlie-and-predict-chemotherapy-resistance-in-triple-negative-breast-cancer
#36
JOURNAL ARTICLE
Mohammed Inayatullah, Arun Mahesh, Arran K Turnbull, J Michael Dixon, Rachael Natrajan, Vijay K Tiwari
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by extensive intratumoral heterogeneity, high metastasis, and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanistic basis of these aggressive behaviors remains poorly understood. Using single-cell and spatial transcriptome analysis, here we discovered basal epithelial subpopulations located within the stroma that exhibit chemoresistance characteristics. The subpopulations are defined by distinct signature genes that show a frequent gain in copy number and exhibit an activated epithelial-to-mesenchymal transition program...
March 13, 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38478384/expression-of-early-growth-response-3-in-skin-cancers
#37
JOURNAL ARTICLE
Kai-Yi Zhou, Li-Jia Deng, Si-Yu Luo, Qin-Xiao Wang, Sheng Fang
OBJECTIVE: To assess the expression of early growth response 3 (EGR3) in normal skin and different types of skin tumors: cutaneous squamous cell carcinoma (cSCC), basal cell carcinoma (BCC), melanoma (MM), and cutaneous adnexal tumors containing sebaceous carcinoma (SC), trichoepithelioma (TE) and clear cell hidradenoma (CCH). BACKGROUND: EGR3, expressed in multiple organs, including skin, plays an important role in cell differentiation and tumor growth. Previous studies have shown that EGR3 suppresses tumor growth and is downregulated in various malignancies...
March 14, 2024: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/38477374/prognostic-value-of-micrometric-substaging-in-pt1-bladder-cancer-patients-treated-with-en-bloc-transurethral-resection
#38
JOURNAL ARTICLE
Takafumi Yanagisawa, Shun Sato, Yasushi Hayashida, Yohei Okada, Akihiro Matsukawa, Kosuke Iwatani, Masayuki Shimoda, Hiroyuki Takahashi, Takahiro Kimura, Shahrokh F Shariat, Jun Miki
AIMS: We aimed to assess the oncological impact of micrometric extent of invasion in patients with pT1 bladder cancer (BCa) who underwent en-bloc resection for bladder tumour (ERBT). METHODS AND RESULTS: We retrospectively analysed the records and specimens of 106 pT1 high-grade BCa patients who underwent ERBT. The extent of invasion, such as depth from basal membrane, number of invasive foci, maximum width of invasive focus, muscularis mucosae invasion and infiltration pattern (pattern A: solid sheet-like, nodular or nested growth, pattern B: trabecular, small cluster or single-cell pattern) were evaluated by a single genitourinary pathologist...
March 13, 2024: Histopathology
https://read.qxmd.com/read/38476515/association-of-squamous-cell-carcinoma-and-hyaluronan-a-scope-of-the-literature
#39
REVIEW
Khalifa Al Ghanim, Katrina M Jaszkul, Andrew Simpson, Eva A Turley
BACKGROUND: Nonmelanotic skin cancer (NMSC) refers to cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma. There have been many factors linked with the development of cSCC; however, ultraviolet radiation is the most notable culprit. Mutations in RAS signaling genes, the CDKN2A gene, and genes encoding components of the NOTCH signaling pathways increase the risk of developing cSCC. Many therapeutic approaches are available for cSCC, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, and topical treatment...
2024: Eplasty
https://read.qxmd.com/read/38474424/secretome-from-magnetically-stimulated-muscle-exhibits-anticancer-potency-novel-preconditioning-methodology-highlighting-htra1-action
#40
JOURNAL ARTICLE
Yee Kit Tai, Jan Nikolas Iversen, Karen Ka Wing Chan, Charlene Hui Hua Fong, Rafhanah Banu Abdul Razar, Sharanya Ramanan, Lye Yee Jasmine Yap, Jocelyn Naixin Yin, Shi Jie Toh, Craig Jun Kit Wong, Pei Fern Angele Koh, Ruby Yun Ju Huang, Alfredo Franco-Obregón
Briefly (10 min) exposing C2C12 myotubes to low amplitude (1.5 mT) pulsed electromagnetic fields (PEMFs) generated a conditioned media (pCM) that was capable of mitigating breast cancer cell growth, migration, and invasiveness in vitro, whereas the conditioned media harvested from unexposed myotubes, representing constitutively released secretome (cCM), was less effective. Administering pCM to breast cancer microtumors engrafted onto the chorioallantoic membrane of chicken eggs reduced tumor volume and vascularity...
March 5, 2024: Cells
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