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https://www.readbyqxmd.com/read/29218279/non-metastatic-non-melanoma-skin-cancers-our-3-years-of-clinical-experiences
#1
Elif Sari
BACKGROUND: Nonmelanoma skin cancers (NMSC) constitute the largest group of skin cancers. In this study, NMSCs were analyzed retrospectively. METHODS: Between June 2013 and March 2017, demographics and comorbidities of patients underwent reconstructive surgery for NMSC; their risk factors, types, diameters, differentiation, localizations, follow-up times, treatment methods and complications were compared and statistically analyzed. RESULTS: Totally, 163 tumors [111 basal cell carcinoma and 52 cutaneous squamous cell carcinoma (cSCC)] were excized from 148 patients (63 females, 85 males)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29217453/tumor-suppressing-effect-of-silencing-of-annexin-a3-expression-in-breast-cancer
#2
Ju-Yeon Kim, Eun Jung Jung, Hee Jin Park, Jeong-Hee Lee, Eun Jin Song, Seung-Jin Kwag, Ji-Ho Park, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee, Soon-Chan Hong
INTRODUCTION: Annexin A3 (ANXA3) participates in various tumor-associated biological processes, including tumor initiation, progression, and metastasis. The present study was designed to investigate the expression and function of ANXA3 in breast cancer cells. MATERIALS AND METHODS: Annexin A3 protein expression in breast cancer cell lines was evaluated using Western blot analysis. ANXA3 expression in MDA-MB 231 breast cancer cells was silenced by RNA interference, and the effects of RNA silencing on cell proliferation, colony forming ability, wound-healing, and invasiveness were evaluated...
November 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29217346/hydrochlorothiazide-use-and-risk-of-non-melanoma-skin-cancer-a-nationwide-case-control-study-from-denmark
#3
Sidsel Arnspang, David Gaist, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, Anton Pottegård
BACKGROUND: Hydrochlorothiazide, one of the most frequently used diuretic and antihypertensive drugs in the United States and Western Europe, is photosensitizing and has previously been linked to lip cancer. OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). METHODS: From the Danish Cancer Registry, we identified patients (cases) with NMSC during 2004-2012...
November 30, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29215599/systematic-analysis-of-transcriptomic-profile-of-renal-cell-carcinoma-under-long-term-hypoxia-using-next-generation-sequencing-and-bioinformatics
#4
Szu-Chia Chen, Feng-Wei Chen, Ya-Ling Hsu, Po-Lin Kuo
Patients with clear cell renal cell carcinoma (ccRCC) are often diagnosed with both von Hippel-Lindau (VHL) mutations and the constitutive activation of hypoxia-inducible factor-dependent signaling. In this study, we investigated the effects of long-term hypoxia in 786-O, a VHL-defective renal cell carcinoma cell line, to identify potential genes and microRNAs associated with tumor malignancy. The transcriptomic profiles of 786-O under normoxia, short-term hypoxia and long-term hypoxia were analyzed using next-generation sequencing...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29213268/exploring-non-metabolic-functions-of-glycolytic-enzymes-in-immunity
#5
REVIEW
Scott M Seki, Alban Gaultier
At the beginning of the twentieth century, discoveries in cancer research began to elucidate the idiosyncratic metabolic proclivities of tumor cells (1). Investigators postulated that revealing the distinct nutritional requirements of cells with unchecked growth potential would reveal targetable metabolic vulnerabilities by which their survival could be selectively curtailed. Soon thereafter, researchers in the field of immunology began drawing parallels between the metabolic characteristics of highly proliferative cancer cells and those of immune cells that respond to perceived threats to host physiology by invading tissues, clonally expanding, and generating vast amounts of pro-inflammatory effector molecules to provide the host with protection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29211494/exhaustion-of-airway-basal-progenitor-cells-in-early-and-established-copd
#6
Moumita Ghosh, York E Miller, Ichiro Nakachi, Jennifer B Kwon, Anna E Barón, Alexandra E Brantley, Daniel T Merrick, Wilbur A Franklin, Robert L Keith, R William Vandivier
RATIONALE: Up to 40% of smokers develop chronic obstructive pulmonary disease (COPD) over a period that spans decades. Despite the importance of COPD, much remains to be learned about susceptibility and pathogenesis, especially during early, pre-diagnostic stages of disease. Airway basal progenitor cells are crucial for lung health and resilience, because of their ability to repair injured airways. In COPD, the normal airway epithelium is replaced with increased basal and secretory (mucous) cells and decreased ciliated cells, suggesting that progenitors are impaired...
December 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29208416/statin-use-and-risk-of-skin-cancer
#7
Brian M Lin, Wen-Qing Li, Eunyoung Cho, Gary C Curhan, Abrar A Qureshi
BACKGROUND: Statins are among the most commonly used medications in the United States, and statin use is associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). However, previous studies are limited by lack of adjustment for important confounders. OBJECTIVE: Examine the relation between statins and skin cancer risk in the Nurses' Health Study and Health Professionals Follow-up Study. METHODS: Cox proportional hazards regression was used to evaluate associations...
December 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29204123/network-modularity-in-breast-cancer-molecular-subtypes
#8
Sergio Antonio Alcalá-Corona, Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Enrique Hernández-Lemus
Breast cancer is a heterogeneous and complex disease, a clear manifestation of this is its classification into different molecular subtypes. On the other hand, gene transcriptional networks may exhibit different modular structures that can be related to known biological processes. Thus, modular structures in transcriptional networks may be seen as manifestations of regulatory structures that tightly controls biological processes. In this work, we identify modular structures on gene transcriptional networks previously inferred from microarray data of molecular subtypes of breast cancer: luminal A, luminal B, basal, and HER2-enriched...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29200695/metaplastic-carcinoma-of-breast-and-neurofibromatosis-1-a-rare-association
#9
Gnanapriya Vellaisamy, Suravi Mohanty, Pritilata Rout, Suraj Manjunath
Neurofibromatosis 1 (NF1) patients are generally at higher risk of developing common malignant tumors such as brain and soft tissue tumors. These patients are 5-fold increased the risk of developing breast cancer by the age of 50 years after that the risk remains the same. The most common reported cancer is infiltrating duct carcinoma. We report a case of 61-year-old female with NF1 presented with pain and breast lump for the past 2 months. On mammography, a retroareolar solid cystic lesion measuring 32 mm × 30 mm × 30 mm was noted which was definitive for malignancy...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29196443/modelling-glioblastoma-tumour-host-cell-interactions-using-adult-brain-organotypic-slice-co-culture
#10
Maria Angeles Marques-Torrejon, Ester Gangoso, Steven M Pollard
Glioblastoma (GBM) is an aggressive incurable brain cancer. The cells that fuel the growth of tumours resemble neural stem cells found in the developing and adult mammalian forebrain. These are referred to as GBM stem cells (GSCs). Similar to neural stem cells, GSCs exhibit a variety of phenotypic states: dormant, quiescent, proliferative and differentiating. How environmental cues within the brain influence these distinct states is not well understood. Laboratory models of GBM can be generated using either genetically engineered mouse models, or via intracranial transplantation of cultured tumour initiating cells (mouse or human)...
December 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29192345/transporter-mediated-interaction-between-platinum-drugs-and-sorafenib-at-the-cellular-level
#11
Verena Schneider, Selim Chaib, Claudia Spanier, Mandy Knapp, Violeta Moscvin, Laura Scordovillo, Alessandra Ewertz, Ulrich Jaehde, Ganna V Kalayda
Combining the multikinase inhibitor sorafenib with the platinum-based chemotherapy of solid tumors was expected to improve treatment outcome. However, in many clinical trials, no benefit from sorafenib addition to the platinum-containing regimen could be demonstrated. Moreover, in some studies, decreased survival of ovarian cancer patients as well as non-small cell lung cancer patients with squamous cell histology was observed. The aim of this study was to investigate the cellular mechanisms of the pharmacological interaction between platinum drugs and sorafenib in different cancer cell lines...
November 30, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29190905/the-exon-38-containing-arhgef11-splice-isoform-is-differentially-expressed-and-is-required-for-migration-and-growth-in-invasive-breast-cancer-cells
#12
Masahiko Itoh, Derek C Radisky, Masaaki Hashiguchi, Hiroyuki Sugimoto
Breast cancer invasion involves the loss of cell-cell junctions and acquisition of an invasive, migratory phenotype, and breast cancer cells of the basal intrinsic subtype are more invasive and metastatic than breast cancer cells of other subtypes. ARHGEF11 is a RhoGEF that was previously shown to bind to the tight junction protein ZO-1 at perijunctional actomyosin ring (PJAR), a network of cortically organized actin and myosin filaments associated with junctional complexes that regulates cell-cell adhesion and polarization...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29189094/fijiwingspolarity-an-open-source-toolkit-for-semi-automated-detection-of-cell-polarity
#13
Leonard L Dobens, Anna Shipman, Jeffrey D Axelrod
Epithelial cells are defined by apical-basal and planar cell polarity (PCP) signaling, the latter of which establishes an orthogonal plane of polarity in the epithelial sheet. PCP signaling is required for normal cell migration, differentiation, stem cell generation and tissue repair, and defects in PCP have been associated with developmental abnormalities, neuropathologies and cancers. While the molecular mechanism of PCP is incompletely understood, the deepest insights have come from Drosophila, where PCP is manifest in hairs and bristles across the adult cuticle and organization of the ommatidia in the eye...
November 30, 2017: Fly
https://www.readbyqxmd.com/read/29187227/obesity-reversibly-depletes-the-basal-cell-population-and-enhances-mammary-epithelial-cell-estrogen-receptor-alpha-expression-and-progenitor-activity
#14
Tamara Chamberlin, Joseph V D'Amato, Lisa M Arendt
BACKGROUND: Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences normal mammary tissue to increase breast cancer risk. We hypothesized that obesity increases the proportion of luminal progenitor cells, which are thought to be the cells of origin for the most common types of breast cancer, potentially leading to an increased risk for breast cancer...
November 29, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29187213/jmjd6-promotes-melanoma-carcinogenesis-through-regulation-of-the-alternative-splicing-of-pak1-a-key-mapk-signaling-component
#15
Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun
BACKGROUND: Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway play critical roles in the pathogenesis of melanoma, how the MAPK signaling is regulated in melanoma carcinogenesis is still not fully understood. METHODS: We characterized JMJD6 expression in melanoma tissue array by immunohistochemistry analysis...
November 29, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29186568/germline-sufu-mutation-carriers-and-medulloblastoma-clinical-characteristics-cancer-risk-and-prognosis
#16
Léa Guerrini-Rousseau, Christelle Dufour, Pascale Varlet, Julien Masliah-Planchon, Franck Bourdeaut, Marine Guillaud-Bataille, Rachid Abbas, Anne-Isabelle Bertozzi, Fanny Fouyssac, Sophie Huybrechts, Stéphanie Puget, Brigitte Bressac-De Paillerets, Olivier Caron, Nicolas Sevenet, Marina Dimaria, Sophie Villebasse, Olivier Delattre, Dominique Valteau-Couanet, Jacques Grill, Laurence Brugières
Background: Germline SUFU mutations predispose to SHH medulloblastoma. Germline SUFU mutations have been reported in nevoid basal cell carcinoma syndrome (NBCCS), but little is known about the cancer risk and clinical spectrum. Patients and methods: We performed a retrospective review of all patients with medulloblastoma and a germline SUFU mutation in France. Results: Twenty-two patients from 17 families were identified with a medulloblastoma and a germline SUFU mutation (median age at diagnosis: 16...
November 24, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29186361/pkk-deletion-in-basal-keratinocytes-promotes-tumorigenesis-after-chemical-carcinogenesis
#17
Luojing Chen, Matthew S Hayden, Elaine S Gilmore, Carolina Alexander-Savino, David Oleksyn, Kathleen Gillespie, Jiyong Zhao, Brian Poligone
Squamous cell carcinoma (SCC) of the skin is a keratinocyte malignancy characterized by tumors presenting on sun exposed areas with surgery being the mainstay treatment. Despite advances in targeted therapy in other skin cancers, such as basal cell carcinoma and melanoma, there have been no such advances in the treatment of SCC. This is partly due to an incomplete knowledge of the pathogenesis of SCC. We have recently identified PKK, a protein kinase C-associated kinase, as a potential tumor suppressor in SCC...
November 22, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29184677/cell-free-dna-analysis-by-sire%C3%A2-next-generation-sequencing-panel-in-non-small-cell-lung-cancer-patients-focus-on-basal-setting
#18
Pasquale Pisapia, Francesco Pepe, Riccardo Smeraglio, Maria Russo, Danilo Rocco, Roberta Sgariglia, Mariantonia Nacchio, Caterina De Luca, Elena Vigliar, Claudio Bellevicine, Giancarlo Troncone, Umberto Malapelle
Background: Non small cell lung cancer (NSCLC) is diagnosed in most cases on small tissue samples, such as cytological preparations and histological biopsies; these limited tissue specimens may be not always sufficient for testing epidermal growth factor receptor (EGFR) mutations and other relevant predictive biomarkers. Cell-free DNA (cfDNA) can be used as a surrogate for EGFR mutational testing, whenever tissue is unavailable. However, the detection of gene mutations on cfDNA is challenging; in fact, the extremely low concentration of circulating tumor DNA requires the implementation of highly sensitive and validated next generation techniques...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29183998/chondroitin-sulfates-mediated-n-cadherin-%C3%AE-catenin-signaling-is-associated-with-basal-like-breast-cancer-cell-invasion
#19
Satomi Nadanaka, Hiroki Kinouchi, Hiroshi Kitagawa
Tumor metastasis involves cancer cell invasion across basement membranes and interstitial tissues. The initial invasion step consists of adherence of the tumor cell to the extracellular matrix (ECM), and this binding transduces a variety of signals from the ECM to the tumor cell. Accordingly, it is critical to establish the mechanisms by which extracellular cues influence the intracellular activities that regulate tumor cell invasion. Here, we found that invasion of the basal-like breast cancer cell line BT-549 is enhanced by the ECM component chondroitin sulfates (CSs)...
November 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29181837/expression-of-liver-x-receptors-in-normal-and-refractory-carcinoma-tissues-of-the-human-lung-and-pancreas
#20
Korehito Kashiwagi, Mai Yanagida, Daiki Matsui, Mizuko Tanaka, Kotaro Sugimoto, Honglei Chen, Naoki Ichikawa-Tomikawa, Shigeru Marubashi, Hiroyuki Suzuki, Hideki Chiba
Liver X receptors (LXRs) participate not only in maintaining cholesterol homeostasis but also in controlling cellular growth in many types of normal and tumor cells. We previously reported that LXRα was aberrantly expressed in human oral squamous cell carcinoma (HOSCC) tissues and cell lines, and that LXR stimulation led to significant reduction of proliferation of HOSCC cells via accelerating cholesterol efflux. Since LXRs and downstream proteins involved in cholesterol metabolism could be also applied as therapeutic targets in small cell lung carcinoma (SCLC) and pancreatic ductal adenocarcinoma (PDAC), we herein analyzed the distribution of LXR proteins in these refractory cancers as well as in normal human lung and pancreatic tissues...
November 28, 2017: Histology and Histopathology
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