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Basal cell cancer

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https://www.readbyqxmd.com/read/29924804/reporters-to-mark-and-eliminate-basal-or-luminal-epithelial-cells-in-culture-and-in-vivo
#1
Olmo Sonzogni, Jennifer Haynes, Laurie A Seifried, Yahia M Kamel, Kai Huang, Michael D BeGora, Faith Au Yeung, Celine Robert-Tissot, Yujing J Heng, Xin Yuan, Gerbug M Wulf, Ken J Kron, Elvin Wagenblast, Mathieu Lupien, Thomas Kislinger, Gregory J Hannon, Senthil K Muthuswamy
The contribution of basal and luminal cells to cancer progression and metastasis is poorly understood. We report generation of reporter systems driven by either keratin-14 (K14) or keratin-8 (K8) promoter that not only express a fluorescent protein but also an inducible suicide gene. Transgenic mice express the reporter genes in the right cell compartments of mammary gland epithelia and respond to treatment with toxins. In addition, we engineered the reporters into 4T1 metastatic mouse tumor cell line and demonstrate that K14+ cells, but not K14- or K8+, are both highly invasive in three-dimensional (3D) culture and metastatic in vivo...
June 20, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29924227/solitary-plantar-basal-cell-carcinoma
#2
Maura Simonetti Junqueira Bourroul, Ludmila Lopes Trindade, Vanessa Soares do Nascimento, Anderson da Costa Lino Costa, Ubirajara Honorato da Silva
Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary non-healing ulcer on the sole of the right foot for two years. Histopathological examination showed a typical nodular basal cell carcinoma, confirmed by positivity to Ber-EP4 on immunohistochemistry. There was no history of trauma, exposure to noxious agents, basal cell nevus syndrome, or xeroderma pigmentosum...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923327/survival-benefit-of-sphingosin-1-phosphate-and-receptors-expressions-in-breast-cancer-patients
#3
Fu-Ju Lei, Bi-Hua Cheng, Pei-Yin Liao, Hsiao-Ching Wang, Wei-Chun Chang, Hsueh-Chou Lai, Juan-Cheng Yang, Yang-Chang Wu, Li-Ching Chu, Wen-Lung Ma
Sphingosine-1-phosphate (S1P) is a bioactive lipid that exerts various pathophysiological functions through binding to its receptor family (S1PRs). Since first report of the breast cancer (BCA) promoting function by S1P production (through the function of sphingosine kinases) and S1P/S1PR signaling, their antagonists have never been successfully progress to clinics after three decades. Taking advantage of bioinformatics linking to gene expression to disease prognosis, we examined the impact of associated genes in BCA patients...
June 20, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29923189/the-new-8th-edition-of-tnm-staging-and-its-implications-for-skin-cancer-a-review-by-the-british-association-of-dermatologists-and-the-royal-college-of-pathologists-united-kingdom
#4
REVIEW
S G Keohane, C M Proby, C Newlands, R J Motley, I Nasr, M F Mohd Mustapa, D N Slater
The 8th edition of TNM (Tumour, Node and Metastasis) has numerous and important changes compared to the 7th edition. Public Health England (PHE) and the Royal College of Pathologists, United Kingdom (RCPath) have adopted the 8th edition of TNM (TNM8) published by the Union for International Cancer Control (UICC) for skin cancer staging. These changes will have an impact on the management of both non-melanoma and melanoma skin cancer by all members of the skin cancer multidisciplinary team. These will also need to be highlighted to commissioners and managers for appropriate service planning...
June 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29921827/differential-expression-and-pathway-analysis-in-drug-resistant-triple-negative-breast-cancer-cell-lines-using-rnaseq-analysis
#5
Safa Shaheen, Febin Fawaz, Shaheen Shah, Dietrich Büsselberg
Triple-negative breast cancer (TNBC) is among the most notorious types of breast cancer, the treatment of which does not give consistent results due to the absence of the three receptors (estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) as well as high amount of molecular variability. Drug resistance also contributes to treatment unresponsiveness. We studied differentially expressed genes, their biological roles, as well as pathways from RNA-Seq datasets of two different TNBC drug-resistant cell lines of Basal B subtype SUM159 and MDA-MB-231 treated with drugs JQ1 and Dexamethasone, respectively, to elucidate the mechanism of drug resistance...
June 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29921733/aromatase-acetylation-patterns-and-altered-activity-in-response-to-sirtuin-inhibition
#6
Kevin Pruitt, Deborah Molehin, Isabel Castro-Piedras, Monica Sharma, Souad R Sennoune, Daphne Arena, Pulak R Manna
Aromatase, a cytochrome P450 member, is a key enzyme involved in estrogen biosynthesis and is dysregulated in the majority of breast cancers. Studies have shown that lysine deacetylase inhibitors (KDI) decrease aromatase expression in cancer cells, yet many unknowns remain regarding the mechanism by which this occurs. While advances have been made to clarify factors involved in the transcriptional regulation of the aromatase gene (CYP19A1). Yet, despite aromatase being a primary target for breast cancer therapy, its post-translational regulation has been virtually unexplored...
June 19, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29921315/expression-of-id4-protein-in-breast-cancer-cells-induces-reprogramming-of-tumour-associated-macrophages
#7
Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino, Giulia Fontemaggi
BACKGROUND: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic switch and progression to malignancy. ID4, a member of the ID (inhibitors of differentiation) family of proteins, is associated with a stem-like phenotype and poor prognosis in basal-like breast cancer. Moreover, ID4 favours angiogenesis by enhancing the expression of pro-angiogenic cytokines interleukin-8, CXCL1 and vascular endothelial growth factor...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29920670/urokinase-plasminogen-activator-protects-periodontal-ligament-fibroblast-from-oxidative-induced-apoptosis-and-dna-damage
#8
M S Ahmad Akhoundi, A Rokn, R Bagheri, N Momeni, M Hodjat
BACKGROUND AND OBJECTIVE: Urokinase-plasminogen activator (uPA) is a serine protease expressed at high basal level in normal gingival cervical fluid. Despite its known pathologic role in tissue proteolysis in periodontitis, little is known concerning uPA physiological function in oral tissue. Recent evidence in cancer cells has implicated the uPA system in DNA repair and anti-apoptotic pathways. This study is aimed to evaluate the protective function of urokinase against oxidative DNA damage in periodontal ligament (PDL) fibroblast, and to propose a new biological role for uPA in oral cavity...
June 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29920512/systems-modelling-of-the-egfr-pyk2-c-met-interaction-network-predicts-and-prioritizes-synergistic-drug-combinations-for-triple-negative-breast-cancer
#9
Sung-Young Shin, Anna-Katharina Müller, Nandini Verma, Sima Lev, Lan K Nguyen
Prediction of drug combinations that effectively target cancer cells is a critical challenge for cancer therapy, in particular for triple-negative breast cancer (TNBC), a highly aggressive breast cancer subtype with no effective targeted treatment. As signalling pathway networks critically control cancer cell behaviour, analysis of signalling network activity and crosstalk can help predict potent drug combinations and rational stratification of patients, thus bringing therapeutic and prognostic values. We have previously showed that the non-receptor tyrosine kinase PYK2 is a downstream effector of EGFR and c-Met and demonstrated their crosstalk signalling in basal-like TNBC...
June 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29914974/long-non-coding-rna-miat-regulates-apoptosis-and-the-apoptotic-response-to-chemotherapeutic-agents-in-breast-cancer-cell-lines
#10
Z A Almnaseer, M Mourtada-Maarabouni
The lncRNA Myocardial Infarction Associated Transcript (MIAT) is involved in a number of diseases, including myocardial infarction and diabetic retinopathy. Emerging evidence suggests that MIAT expression levels are increased in different type of cancers, including breast cancer. In this study we further evaluated the role of MIAT in breast cancer and investigated the consequences of its silencing on breast cancer response to chemotherapeutic agents. Expression levels of MIAT mRNA in breast cancer were determined using TissueScan™ Breast Cancer cDNA Arrays...
June 18, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29912582/biomarkers-of-aggressiveness-in-genitourinary-tumors-with-emphasis-on-kidney-bladder-and-prostate-cancer
#11
Alessia Cimadamore, Silvia Gasparrini, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Nicola Battelli, Francesco Massari, Francesca Giunchi, Michelangelo Fiorentino, Marina Scarpelli, Rodolfo Montironi
Over the last decade, the improvement in molecular techniques and the acquisition of genomic information has transformed and increased the quality of patient care and our knowledge of diseases. Areas covered: Protein expression levels in immunohistochemistry and molecular biomarkers are reported for their ability to predict recurrence, progression, development of metastases, or patient survival. In particular, for renal cell carcinoma, we take into consideration the biomarkers applicable to immunohistochemistry and with molecular and genetic analyses...
June 18, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29911527/basal-cell-carcinoma-of-the-buttock
#12
REVIEW
Philip R Cohen
Basal cell carcinoma of the buttock is rare, and only 28 patients have been described. An extensive literature search was performed on basal cell carcinoma and buttock using the PubMed database. The literature was evaluated, and the characteristics of individuals with basal cell carcinoma of the buttock were summarized. The calculated prevalence of basal cell carcinoma of the buttock was 0.35%. The majority of patients had no obvious basal cell carcinoma-associated risk factors. Carcinomas were observed 1.2 times more often in women than in men, and more often on the right buttock...
2018: Skinmed
https://www.readbyqxmd.com/read/29910679/the-suppression-of-dusp5-expression-correlates-with-paclitaxel-resistance-and-poor-prognosis-in-basal-like-breast-cancer
#13
Tieju Liu, Huizhi Sun, Shiqi Liu, Zhao Yang, Linqi Li, Nan Yao, Siqi Cheng, Xueyi Dong, Xiaohui Liang, Chen Chen, Yi Wang, Xiulan Zhao
Basal-like breast cancer (BLBC) is resistant to endocrinotherapy and targeted therapy and new molecular therapies are needed for BLBC. In this study, we evaluated the role of DUSP1 and DUSP5, negative regulators of mitogen-activated protein kinase pathway, in the aggressiveness of BLBC. MDA-MB-231 cells were given paclitaxel (PTX) treatment and subsequently PTX resistant cell clones were established. Microarray analysis, real-time quantitative reverse transcription PCR (qRT-PCR), and online analysis of large cohorts of breast cancer patients were performed...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29909488/histological-changes-of-superficial-esophageal-squamous-cell-carcinoma-after-preoperative-chemotherapy
#14
Takahito Sugase, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Tadayoshi Hashimoto, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masayuki Mano, Eiichi Morii, Masaki Mori, Yuichiro Doki
INTRODUCTION: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). METHODS: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining...
June 16, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29906688/in-vitro-and-in-vivo-studies-of-gold-i-azolate-phosphane-complexes-for-the-treatment-of-basal-like-breast-cancer
#15
Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amici
Basal like breast cancer (BLBC) is a very aggressive subtype of breast cancer giving few chances of survival, against which cisplatin based therapy is a compromise among the anticancer activity, the resistance development and the severe side effects. With the aim of finding new anticancer agents alternative to cisplatin, seven gold(I) azolate/phosphane compounds were evaluated in vitro by MTT tests in human MDA-MB-231, human mammary epithelial HMLE cells overexpressing FoxQ1, and murine A17 cells as models of BLBC...
June 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29902298/prevalence-of-pdl1-amplification-and-preliminary-response-to-immune-checkpoint-blockade-in-solid-tumors
#16
Aaron M Goodman, David Piccioni, Shumei Kato, Amélie Boichard, Huan-You Wang, Garrett Frampton, Scott M Lippman, Caitlin Connelly, David Fabrizio, Vincent Miller, Jason K Sicklick, Razelle Kurzrock
Importance: Copy number alterations in programmed cell death ligand 1 (PDL1 or CD274), programmed cell death 1 ligand 2 (PDCD1LG2 or PDL2), and Janus kinase 2 (JAK2) genes (chromosome 9p24.1) characterize Hodgkin lymphoma, resulting in high response rates to programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade. The prevalence and utility of PDL1 amplification as a response biomarker to PD-1/PD-L1 blockade are unknown in other tumors. Objectives: To examine the prevalence of PDL1 amplification and its utility as a response biomarker to PD-1/PD-L1 blockade in solid tumors...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29901166/alternative-splicing-variant-of-rhbdd2-is-associated-with-cell-stress-response-and-breast-cancer-progression
#17
Romina Canzoneri, Martín Enrique Rabassa, Agustina Gurruchaga, Valeria Ferretti, Sabina Palma, Marina Isla-Larrain, María Virginia Croce, Ezequiel Lacunza, Martín Carlos Abba
RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two alternative transcriptional variants have been described for RHBDD2, which would be encoding for different RHBDD2 protein isoforms. The expression of these RHBDD2 variants/isoforms and its association with breast cancer was the focus of this study. First, expression of RHBDD2 splicing variants was evaluated in normal and breast tumor samples...
June 14, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901100/implications-of-nestin-in-breast-cancer-pathogenesis-review
#18
Aleksandra Nowak, Piotr Dziegiel
The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC and other cancer types. In normal breast tissue, nestin is expressed in the basal/myoepithelial cells of the mammary gland. In BC, nestin identifies basal-like tumours and predicts aggressive behaviour and poor prognosis...
June 14, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29900551/collagen-disruption-as-a-marker-for-basal-cell-carcinoma-in-presurgical-margin-detection
#19
Pooyan Rohani, Anna N Yaroslavsky, Xin Feng, Peter Jermain, Tarek Shaath, Victor A Neel
INTRODUCTION AND OBJECTIVE: Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States. Surgery is the most common treatment for these tumors, but pre-operative identification of surgical margins is challenging. The objective in this study was to determine whether optical polarization imaging (OPI) could be used prior to surgery to detect the extent of subclinical tumor spread by monitoring disruption in collagen. MATERIALS AND METHODS: OPI is a non-invasive and rapid imaging modality that highlights the structure of dermal collagen...
June 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29899846/conception-synthesis-and-characterization-of-a-rofecoxib-combretastatin-hybrid-drug-with-potent-cyclooxygenase-2-cox-2-inhibiting-and-microtubule-disrupting-activities-in-colon-cancer-cell-culture-and-xenograft-models
#20
Surendra R Punganuru, Hanumantha Rao Madala, Constantinos M Mikelis, Anshuman Dixit, Viswanath Arutla, Kalkunte S Srivenugopal
Tumor heterogeneity and drug resistance pose severe limitations to chemotherapy of colorectal cancers (CRCs) necessitating innovative approaches to trigger multiple cytocidal events for increased efficacy. Here, we developed a hybrid drug called KSS19 by combining the COX-2 selective NSAID rofecoxib with the cis-stilbene found in combretastatin A4 (CA4), a problematic, but potent antimicrotubule and anti-angiogenesis agent. The structural design of KSS19 completely prevented the isomerization of CA4 its biologically inactive trans-form...
May 25, 2018: Oncotarget
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