keyword
MENU ▼
Read by QxMD icon Read
search

Dementia risk factors

keyword
https://www.readbyqxmd.com/read/29345106/national-study-of-the-nutritional-status-of-korean-older-adults-with-dementia-who-are-living-in-long-term-care-settings
#1
Myonghwa Park, Jun-Ah Song, Mihyun Lee, Hyun Jeong, Soyeun Lim, Haejung Lee, Chun-Gill Kim, Jeong S Kim, Kyung S Kim, Young W Lee, Young M Lim, Young S Park, Jong C Yoon, Ki W Kim, Gwi-Ryung S Hong
AIM: To evaluate the nutritional status of older adults with dementia who were living in long-term care settings. METHODS: As a secondary analysis, this study used the data from the Nationwide Survey on Dementia Care in Korea that was conducted between December 1, 2010, and August 31, 2011, which surveyed 3472 older adults with dementia, aged ≥60 years (mean age: 81.24 years), who were residing in 248 randomly selected long-term care settings in South Korea...
January 17, 2018: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29343976/epidemiology-associated-burden-and-current-clinical-practice-for-the-diagnosis-and-management-of-alzheimer-s-disease-in-japan
#2
REVIEW
William Montgomery, Kaname Ueda, Margaret Jorgensen, Shari Stathis, Yuanyuan Cheng, Tomomi Nakamura
The burden of dementia in Japan is large and growing. With the world's fastest aging population, it is estimated that one in five elderly people will be living with dementia in Japan by 2025. The most common form of dementia is Alzheimer's disease (AD), accounting for around two-thirds of dementia cases. A systematic review was conducted to examine the epidemiology and associated burden of AD in Japan and to identify how AD is diagnosed and managed in Japan. English and Japanese language databases were searched for articles published between January 2000 and November 2015...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29338817/correlation-of-stress-hyperglycemia-after-ischemic-stroke-with-early-vascular-cognitive-impairment
#3
Yi Dong Zhou, Huai Wu Yuan, Ren Jie Ji, Ben Yan Luo
Objective To investigate the influence and forecast value of stress hyperglycemia on the early vascular cognitive impairment (VCI) in stroke patients.Methods Totally 422 patients with acute non-diabetic stroke were divided into three groups according to the fasting plasma glucose level:the euglycemia group (<6.1 mmol/L),the mild stress hyperglycemia group (6.1-7.0 mmol/L),and the severe stress hyperglycemia group (≥7.0 mmol/L).Mini-mental state examination,Alzheimer's disease rating scale cognitive subscale,and clinical dementia rating scale were used to evaluate early cognition in post-stroke patients,and patients were divided into three groups accordingly:normal cognitive function group,mild VCI group,and vascular dementia group...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29338663/cultural-competency-in-dementia-care-an-african-american-case-study
#4
Jennie Leeder Clark, Sarah Phoenix, Ann Choryan Bilbrey, Terese McManis, Kristel Anne Escal, Rohini Arulanantham, Tiana Sisay, Rita Ghatak
Age is the greatest risk factor for Alzheimer's disease, the most common cause of dementia. The older population in the United States is growing, and within this demographic ethnic and racial diversity is also on the rise. This article introduces Stanford Health Care's Memory Support Program (MSP) as a model for culturally competent dementia care that spans inpatient and outpatient settings. The case study of an African American patient and family dealing with an Alzheimer's disease diagnosis and comorbid conditions is presented and explored to illustrate the MSP model...
December 26, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29336840/heterozygous-tyrobp-deletion-ploslfin-is-not-a-strong-risk-factor-for-cognitive-impairment
#5
Karri Kaivola, Lilja Jansson, Elmo Saarentaus, Anna Kiviharju, Ville Rantalainen, Johan G Eriksson, Timo E Strandberg, Tuomo Polvikoski, Liisa Myllykangas, Pentti J Tienari
Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's disease when heterozygous. Here, we studied the PLOSLFINTYROBP deletion that covers 4 of the gene's 5 exons. We genotyped 3220 older Finns (mean age 79, range 58-104) and found 11 deletion carriers (mean age 78, range 60-94)...
December 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29335318/longitudinal-effect-of-stroke-on-cognition-a-systematic-review
#6
REVIEW
Eugene Yh Tang, Obreniokibo Amiesimaka, Stephanie L Harrison, Emma Green, Christopher Price, Louise Robinson, Mario Siervo, Blossom Cm Stephan
BACKGROUND: Stroke is associated with an increased risk of dementia; however, the impact of stroke on cognition has been found to be variable, such that stroke survivors can show decline, remain stable, or revert to baseline cognitive functioning. Knowing the natural history of cognitive impairment after stroke is important for intervention. The aim of this systematic review is to investigate the longitudinal course of cognitive function in stroke survivors. METHODS AND RESULTS: Three electronic databases (Medline, Embase, PsycINFO) were searched using OvidSP from inception to July 15, 2016...
January 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29332048/frequency-of-cardiovascular-genetic-risk-factors-in-a-calabrian-population-and-their-effects-on-dementia
#7
Raffaele Maletta, Nicoletta Smirne, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Rosanna Colao, Gianfranco Puccio, Sabrina A M Curcio, Valentina Laganà, Francesca Frangipane, Chiara Cupidi, Maria Mirabelli, Franca Vasso, Giusi Torchia, Maria G Muraca, Raffaele Di Lorenzo, Giuseppina Rose, Alberto Montesanto, Giuseppe Passarino, Amalia C Bruni
BACKGROUND: Several genetic variants playing a key role in cholesterol levels, blood pressure, and vascular dysfunction influence the risk of Alzheimer's disease (AD) and vascular dementia (VaD). The many meta-analysis studies carried out on large numbers of samples in different populations have not provided clear results to date, because a trans-ethnic shift of risk genotypes in different populations is often observed. OBJECTIVES: To determine genotypes allele frequencies of the polymorphisms most frequently identified to be correlated with cardio-cerebrovascular disease and AD in a Southern Italy population and to investigate their possible association with dementia...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29332010/oligogenic-genetic-variation-of-neurodegenerative-disease-genes-in-980-postmortem-human-brains
#8
Michael J Keogh, Wei Wei, Juvid Aryaman, Ian Wilson, Kevin Talbot, Martin R Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj, Chris M Morris, Olaf Ansorge, Stuart Pickering-Brown, Nick Jones, James W Ironside, Patrick F Chinnery
BACKGROUND: Several studies suggest that multiple rare genetic variants in genes causing monogenic forms of neurodegenerative disorders interact synergistically to increase disease risk or reduce the age of onset, but these studies have not been validated in large sporadic case series. METHODS: We analysed 980 neuropathologically characterised human brains with Alzheimer's disease (AD), Parkinson's disease-dementia with Lewy bodies (PD-DLB), frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) and age-matched controls...
January 13, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29326289/prevalence-of-hippocampal-enlarged-perivascular-spaces-in-a-sample-of-patients-with-hypertension-and-their-relation-with-vascular-risk-factors-and-cognitive-function
#9
Joan Jiménez-Balado, Iolanda Riba-Llena, Edurne Garde, Marta Valor, Belen Gutiérrez, Francesc Pujadas, Pilar Delgado
OBJECTIVES: The clinical importance of hippocampal enlarged perivascular spaces (H-EPVS) remains uncertain. We aimed to study their association with vascular risk factors, cognitive function and mild cognitive impairment (MCI). METHODS: Data were obtained from the ISSYS (Investigating Silent Strokes in hYpertensives, a magnetic resonance imaging Study) cohort, which is a prospective study of patients with hypertension aged 50-70 with no prior stroke or dementia...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29324915/self-report-instruments-of-cognitive-failures-as-screening-tools-for-subjective-cognitive-impairment-in-older-adults
#10
Vasileios Papaliagkas, G Papantoniou, Magda Tsolaki, Despina Moraitou
BACKGROUND: The term "Subjective Cognitive Impairment (SCI)" is the most widely accepted term for cognitive complaints of otherwise apparently healthy older adults. It is presently clear that SCI might be a risk factor for the development of Mild Cognitive Impairment and dementia. As regards SCI measurement and potential diagnosis, several studies showed that SCI is a condition in which people score in the normal range on common tests but believe they experience cognitive decline. Hence, to assess the characteristic of the SCI subtle cognitive decline, self-report measures were developed to estimate "self-experience" of minimal decline in cognition seem the most appropriate tools...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29319603/population-neuroscience-dementia-epidemiology-serving-precision-medicine-and-population-health
#11
Mary Ganguli, Emiliano Albanese, Sudha Seshadri, David A Bennett, Constantine Lyketsos, Walter A Kukull, Ingmar Skoog, Hugh C Hendrie
Over recent decades, epidemiology has made significant contributions to our understanding of dementia, translating scientific discoveries into population health. Here, we propose reframing dementia epidemiology as "population neuroscience," blending techniques and models from contemporary neuroscience with those of epidemiology and biostatistics. On the basis of emerging evidence and newer paradigms and methods, population neuroscience will minimize the bias typical of traditional clinical research, identify the relatively homogenous subgroups that comprise the general population, and investigate broader and denser phenotypes of dementia and cognitive impairment...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29316447/circulating-metabolites-and-general-cognitive-ability-and-dementia-evidence-from-11-cohort-studies
#12
Sven J van der Lee, Charlotte E Teunissen, René Pool, Martin J Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Andres Metspalu, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francien A de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M Arfan Ikram, Maik Pietzner, Markus Perola, Michael Wagner, Nele Friedrich, P E Slagboom, Philip Scheltens, Qiong Yang, Robert E Gertzen, Sarah Egert, Shuo Li, Thomas Hankemeier, Catharine E M van Beijsterveldt, Vasan Ramachandran, Wolfgang Maier, Carel F W Peeters, Hans Jörgen Grabe, Alfredo Ramirez, Sudha Seshadri, Toomas Haller, Mika Kivimäki, Veikko Salomaa, Ayşe Demirkan, Dorret Boomsma, Wiesje M van der Flier, Najaf Amin, Cornelia M van Duijn
INTRODUCTION: Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. METHODS: We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined...
January 6, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29314273/psychological-well-being-and-risk-of-dementia
#13
Angelina R Sutin, Yannick Stephan, Antonio Terracciano
OBJECTIVE: Well-being is a psychological resource that buffers against age-related disease. We test whether this protective effect extends to dementia and whether it is independent of distress. METHODS: Participants (N = 10,099) were from the Health and Retirement Study. Five aspects of positive psychological functioning (life satisfaction, optimism, mastery, purpose in life, and positive affect) were tested as predictors of incident dementia over 6 to 8 years...
January 3, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29313420/knowledge-of-dementia-among-the-australian-health-workforce-a-national-online-survey
#14
Michael J Annear
Dementia is a leading cause of death and disability in Australia. This research evaluated dementia knowledge and educational needs among the Australian health workforce. An online version of the validated Dementia Knowledge Assessment Scale (DKAS) was administered with a random sample of 234 health professionals across eight Australian states. Respondents provided additional self-report data concerning dementia experiences, educational needs, and demographic information. Dementia knowledge deficiencies were identified concerning risk factors, prevalent typologies of the condition, and cognitive symptoms...
January 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29310831/inadequate-fluid-intake-in-long-term-care-residents-prevalence-and-determinants
#15
Ashwini M Namasivayam-MacDonald, Susan E Slaughter, Jill Morrison, Catriona M Steele, Natalie Carrier, Christina Lengyel, Heather H Keller
Dehydration is estimated to be present in half of long term care residents, as many do not consume the recommended levels of fluid intake. This study aims to describe fluid intake in long term care residents and identify the factors associated with fluid intake. Data were collected from 622 long term care residents, with a mean age of 86.8 ± 7.8. Total fluid intake was estimated over three non-consecutive days. Potential resident and unit-level variables risk factors for low fluid intake were collected, such as dementia status, activities of daily living, and eating challenges...
January 5, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29310663/%C3%AE-synuclein-accumulation-and-gba-deficiency-due-to-l444p-gba-mutation-contributes-to-mptp-induced-parkinsonism
#16
Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L Dawson, Ted M Dawson, Yunjong Lee, Han Seok Ko
BACKGROUND: Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibility of nigrostriatal dopamine (DA) neurons in L444P GBA heterozygous knock-in (GBA +/L444P ) mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a selective dopaminergic mitochondrial neurotoxin...
January 8, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29309201/guilt-after-placement-questionnaire-a-new-instrument-to-assess-caregiver-emotional-functioning-following-nursing-home-placement
#17
Jennifer Duncan Davis, Benjamin D Hill, Sarah Pillemer, Joshua Taylor, Geoffrey Tremont
OBJECTIVE: Guilt is a core feature of dementia caregivers' experiences following placement. This study describes and validates a new assessment tool for monitoring caregiver adjustment after placement. METHODS: Forty-six items addressing ambivalence and guilt about placement were tested with 170 dementia caregivers (M age = 56.79, SD = 13.19; 69.4% female; 54.7% adult child). RESULTS: Using principal axis factor analysis, 10 items were retained that showed acceptable internal consistency (Cronbach's alpha of 0...
January 8, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29308992/goal-setting-to-promote-a-healthier-lifestyle-in-later-life-qualitative-evaluation-of-the-agewell-trial
#18
Sharon M Nelis, Jeanette M Thom, Ian Rees Jones, John V Hindle, Linda Clare
OBJECTIVE: We report a mixed method evaluation of the feasibility and implementation of the AgeWell goal-setting intervention to promote healthy ageing later life. METHOD: Researcher field notes, goal-setting interview content, and semi-structured interviews with participants were content analysed to review trial implementation and participants' perspective on the goal-setting and mentoring intervention. RESULTS: 75 people were recruited: 21 in the goal-setting and 22 in the goal-setting with mentoring arms of the intervention...
December 15, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29307083/in-thai-nationals-the-apoe4-allele-affects-multiple-domains-of-neuropsychological-biobehavioral-and-social-functioning-thereby-contributing-to-alzheimer-s-disorder-while-the-apoe3-allele-protects-against-neuropsychiatric-symptoms-and-psychosocial-deficits
#19
Sookjaroen Tangwongchai, Thitiporn Supasitthumrong, Solaphat Hemrunroj, Chavit Tunvirachaisakul, Phenphichcha Chuchuen, Natnicha Houngngam, Thiti Snabboon, Ittipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchindad, Michael Maes
The apolipoprotein E epsilon 4 (ApoE4) allele is the strongest genetic risk factor for Alzheimer's disorder (AD) and is associated with semantic and episodic memory deficits. The aim of this study was to examine the associations between ApoE alleles (E2, E3, E4) and genotypes and neuropsychological tests, behavioral functions, and dementia symptoms as assessed using Consortium to Establish a Registry for Alzheimer's Disease (CERAD). This study included 60 patients with Alzheimer's disorder (AD), 60 with mild cognitive disorder (MCI), and 62 normal volunteers...
January 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29305919/pathological-role-of-lipid-interaction-with-%C3%AE-synuclein-in-parkinson-s-disease
#20
REVIEW
Mari Suzuki, Kazunori Sango, Keiji Wada, Yoshitaka Nagai
Alpha-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In sporadic PD and DLB, normally harmless αSyn proteins without any mutations might gain toxic functions by unknown mechanisms. Thus, it is important to elucidate the factors promoting the toxic conversion of αSyn, towards understanding the pathogenesis of and developing disease-modifying therapies for PD and DLB. Accumulating biophysical and biochemical studies have demonstrated that αSyn interacts with lipid membrane, and the interaction influences αSyn oligomerization and aggregation...
January 3, 2018: Neurochemistry International
keyword
keyword
34709
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"