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anemia induce in rats

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https://www.readbyqxmd.com/read/29738538/the-hypoxia-inducible-factor-erythropoietin-epo-epo-receptor-pathway-is-disturbed-in-a-rat-model-of-chronic-kidney-disease-related-anemia
#1
Daniel Landau, Lital London, Inbar Bandach, Yael Segev
OBJECTIVES: Anemia is a known driver for hypoxia inducible factor (HIF) which leads to increased renal erythropoietin (EPO) synthesis. Bone marrow (BM) EPO receptor (EPOR) signals are transduced through a JAK2-STAT5 pathway. The origins of anemia of chronic kidney disease (CKD) are multifactorial, including impairment of both renal EPO synthesis as well as intestinal iron absorption. We investigated the HIF- EPO- EPOR axis in kidney, BM and proximal tibia in anemic juvenile CKD rats. METHODS: CKD was induced by 5/6 nephrectomy in young (20 days old) male Sprague-Dawley rats while C group was sham operated...
2018: PloS One
https://www.readbyqxmd.com/read/29674278/cassia-grandis-fruit-extract-reduces-the-blood-glucose-level-in-alloxan-induced-diabetic-rats
#2
Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Hady Keita, Edgar Puente Zapata, Helison Carvalho, Emersom Silva Lima, Tatiane Pereira de Sousa, José Carlos Tavares Carvalho
INTRODUCTION: Cassia grandis Lf fruits are ethnobotanically used for digestive disorders, anemia, and for reducing blood glucose. However, there are no studies about the antidiabetic activity nor the oral toxicity of the plant fruit-extracts. This paper aims to evaluate the hypoglycemic effect of C. grandis fruits extract in vivo, and assess the acute oral toxicity, and sub-acute oral toxicity. The antioxidant activity and the α-glycosidase inhibitor effect were also evaluated. METHODS: The extract was obtained by maceration of the fruit pulp with 70% hydroalcoholic solution (1:2, m:v)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29668046/black-cohosh-extracts-and-powders-induce-micronuclei-a-biomarker-of-genetic-damage-in-human-cells
#3
Stephanie L Smith-Roe, Carol D Swartz, Kim G Shepard, Steven M Bryce, Stephen D Dertinger, Suramya Waidyanatha, Grace E Kissling, Scott S Auerbach, Kristine L Witt
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant increases in micronucleated erythrocytes in peripheral blood of female Wistar Han rats and B6C3F1/N mice administered 15-1,000 mg BCE/kg/day by gavage for 90 days. These animals also developed a dose-dependent nonregenerative macrocytic anemia characterized by clinical changes consistent with megaloblastic anemia...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29652520/hemolysis-induced-lung-vascular-leakage-contributes-to-the-development-of-pulmonary-hypertension
#4
Olga Rafikova, Elissa R Williams, Matthew L McBride, Marina Zemskova, Anup Srivastava, Vineet Nair, Ankit A Desai, Paul R Langlais, Evgeny Zemskov, Marc Simon, Lawrence J Mandarino, Ruslan Rafikov
RATIONALE: While hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic PAH alone, the role of hemolysis in the development of PAH is poorly characterized. OBJECTIVES: We hypothesized that hemolysis independently contributes to PAH pathogenesis via endothelial barrier dysfunction with resulting perivascular edema and inflammation. METHODS: Plasma samples from patients with and without PAH (both confirmed by right heart catheterization) were used to measure free hemoglobin (Hb) and its correlation with PAH severity...
April 13, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29587599/pathological-and-clinical-pathological-changes-induced-by-four-week-repeated-dose-oral-administration-of-the-wood-preservative-chromated-copper-arsenate-in-wistar-rats
#5
Naofumi Takahashi, Toshinori Yoshida, Sayuri Kojima, Satoru Yamaguchi, Ryoichi Ohtsuka, Makio Takeda, Tadashi Kosaka, Takanori Harada
Chromated copper arsenate (CCA) is used as a wood preservative worldwide. Exposure to it may adversely affect human health. Some events have increased human exposure to CCA, including the Great East Japan Earthquake, which generated a large amount of lumber debris from CCA-treated woods. We elucidated the toxicity due to daily exposure to CCA over a 4-week period at doses of 0, 8, 40, and 80 mg/kg/day in Wistar Hannover rats. Chromium (Cr) and arsenic (As), but not copper, were detected in the plasma samples of rats treated with various doses of CCA...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29573618/umbelliferone-prevents-oxidative-stress-inflammation-and-hematological-alterations-and-modulates-glutamate-nitric-oxide-cgmp-signaling-in-hyperammonemic-rats
#6
Mousa O Germoush, Sarah I Othman, Maha A Al-Qaraawi, Hanan M Al-Harbi, Omnia E Hussein, Gadh Al-Basher, Mohammed F Alotaibi, Hassan A Elgebaly, Mansur A Sandhu, Ahmed A Allam, Ayman M Mahmoud
Hepatic encephalopathy (HE) is a serious neuropsychiatric complication that occurs as a result of liver failure. Umbelliferone (UMB; 7-hydroxycoumarin) is a natural product with proven hepatoprotective activity; however, nothing has yet been reported on its protective effect against hyperammonemia, the main culprit behind the symptoms of HE. Here, we evaluated the effect of UMB against ammonium chloride (NH4 Cl)-induced hyperammonemia, oxidative stress, inflammation and hematological alterations in rats. We demonstrated the modulatory role of UMB on the glutamate-nitric oxide (NO)-cGMP pathways in the cerebrum of rats...
March 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29570451/evaluating-of-%C3%AE-carotene-role-in-ameliorating-of-favism-induced-disturbances-in-blood-and-testis
#7
Khaled M M Koriem, Mahmoud S Arbid
Background Favism is an acute hemolytic anemia occurs in glucose 6-phosphate dehydrogenase (G6-PD) deficient individuals. β-Carotene occurs in vegetables such as carrots. This study aimed to establish the therapeutic effect of β-carotene to rebalance the testicular and blood proteins disturbances in favism. Methods Forty-eight male rats were divided into six equal groups; Groups 1, 2 and 3: normal rats were daily oral administrated with 1 ml saline, 1 ml corn oil and β-carotene (60 mg/kg dissolved in 1 ml corn oil), respectively, once a day over 15 days period...
March 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29551975/integrated-metabolomics-and-network-pharmacology-approach-to-explain-possible-action-mechanisms-of-xin-sheng-hua-granule-for-treating-anemia
#8
Han-Qing Pang, Shi-Jun Yue, Yu-Ping Tang, Yan-Yan Chen, Ya-Jie Tan, Yu-Jie Cao, Xu-Qin Shi, Gui-Sheng Zhou, An Kang, Sheng-Liang Huang, Ya-Jun Shi, Jing Sun, Zhi-Shu Tang, Jin-Ao Duan
As a well-known traditional Chinese medicine (TCM) prescription, Xin-Sheng-Hua Granule (XSHG) has been applied in China for more than 30 years to treat postpartum diseases, especially anemia. However, underlying therapeutic mechanisms of XSHG for anemia were still unclear. In this study, plasma metabolomics profiling with UHPLC-QTOF/MS and multivariate data method was firstly analyzed to discover the potential regulation mechanisms of XSHG on anemia rats induced by bleeding from the orbit. Afterward, the compound-target-pathway network of XSHG was constructed by the use of network pharmacology, thus anemia-relevant signaling pathways were dissected...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29517782/antidiabetic-effects-and-erythrocyte-stabilization-by-red-cabbage-extract-in-streptozotocin-treated-rats
#9
Vyacheslav Buko, Ilya Zavodnik, Olena Kanuka, Elena Belonovskaya, Elena Naruta, Oxana Lukivskaya, Siargej Kirko, Grazyna Budryn, Danuta Żyżelewicz, Joanna Oracz, Natalia Sybirna
The protective effect of red cabbage extract (RCE) was evaluated in rats with streptozotocin-induced diabetes, assessing a probable role of this extract in the prevention of erythrocyte impairments associated with a high risk of vascular complications in diabetes. RCE was analyzed by ultrahigh performance liquid chromatography and mass spectrometry, and 11 anthocyanins, 3 hydroxybenzoic acids and 9 hydroxycinnamic acids were identified. Type 1 diabetes was induced by streptozotocin (60 mg kg-1 ) in Wistar male rats (n = 8 per group)...
March 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29462631/rapidly-dissolving-microneedle-patches-for-transdermal-iron-replenishment-therapy
#10
Abhijeet Maurya, Shivakumar H Nanjappa, Swati Honnavar, M Salwa, S Narasimha Murthy
The prevalence of iron deficiency anemia (IDA) is predominant in women and children especially in developing countries. The disorder affects cognitive functions and physical activity. Although oral iron supplementation and parenteral therapy remains the preferred choice of treatment, gastric side effects and risk of iron overload decreases adherence to therapy. Transdermal route is an established approach, which circumvents the side effects associated with conventional therapy. In this project, an attempt was made to investigate the use of rapidly dissolving microneedles loaded with ferric pyrophosphate (FPP) as a potential therapeutic approach for management of IDA...
February 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29374477/epoetin-beta-pegol-for-treatment-of-anemia-ameliorates-deterioration-of-erythrocyte-quality-associated-with-chronic-kidney-disease
#11
Ken Aizawa, Ryohei Kawasaki, Yoshihito Tashiro, Yasushi Shimonaka, Michinori Hirata
BACKGROUND: Epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R.A.) is currently widely used for the treatment of anemia associated with chronic kidney disease (CKD). Therapeutic control of anemia is assessed by monitoring haemoglobin (Hb) levels. However, certain qualitative aspects of erythrocytes are also impaired in CKD, including loss of deformability and shortened life-span. Therefore, monitoring Hb alone could potentially fail to reveal pathological changes in erythrocytes...
January 27, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29259755/discovery-of-jtz-951-a-hif-prolyl-hydroxylase-inhibitor-for-the-treatment-of-renal-anemia
#12
Yosuke Ogoshi, Takuya Matsui, Ikuo Mitani, Masahiro Yokota, Masakazu Terashita, Dai Motoda, Kazuhito Ueyama, Takahiro Hotta, Takashi Ito, Yasunori Hase, Kenji Fukui, Katsuya Deai, Hiromi Yoshiuchi, Soichiro Ito, Hiroyuki Abe
Inhibition of hypoxia inducible factor prolyl hydroxylase (PHD) represents a promising strategy for the discovery of a next generation treatment for renal anemia. We identified several 5,6-fused ring systems as novel scaffolds of the PHD inhibitor on the basis of pharmacophore analysis. In particular, triazolopyridine derivatives showed potent PHD2 inhibitory activities. Examination of the predominance of the triazolopyridines in potency by electrostatic calculations suggested favorable π-π stacking interactions with Tyr310...
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29187641/vasopressin-stimulates-the-proliferation-and-differentiation-of-red-blood-cell-precursors-and-improves-recovery-from-anemia
#13
Balázs Mayer, Krisztián Németh, Miklós Krepuska, Vamsee D Myneni, Dragan Maric, John F Tisdale, Matthew M Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildikó Szalayova, Jerome Pagani, Károly Markó, Ian McClain-Caldwell, Lynn Vitale-Cross, W Scott Young, Michael J Brownstein, Éva Mezey
Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus. We observed that many of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells...
November 29, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29184226/antioxidant-activity-and-protective-effect-of-bee-bread-honey-and-pollen-in-aluminum-induced-anemia-elevation-of-inflammatory-makers-and-hepato-renal-toxicity
#14
Meryem Bakour, Noori S Al-Waili, Nawal El Menyiy, Hamada Imtara, Anna Cristina Figuira, Thia Al-Waili, Badiaa Lyoussi
Aluminum toxicity might be related to oxidative stress, and the antioxidant activity and protective effect of bee bread, which contains pollen, honey and bees' enzymes, on aluminum induced blood and hepato-renal toxicity was investigated in rats. Chemical analysis and antioxidant capacity of bee bread were conducted. The animal experiment in rats included; group 1: received distilled water (10 ml/kg b.wt), group 2: received aluminum chloride (662.2 mg/kg b.wt), group 3: received aluminum chloride (662.2 mg/kg b...
December 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29175668/grape-seed-procyanidin-extract-ameliorates-lead-induced-liver-injury-via-mirna153-and-akt-gsk-3%C3%AE-fyn-mediated-nrf2-activation
#15
Biying Liu, Huijie Jiang, Jingjing Lu, Ruiqi Baiyun, Siyu Li, Yueying Lv, Da Li, Hao Wu, Zhigang Zhang
Lead-induced hepatotoxicity is characterized by an extensive oxidative stress. Grape seed procyanidin extract (GSPE) possesses abundant biological activities. Herein, we investigated the protective role of GSPE against lead-induced liver injury and determined the potential molecular mechanisms. In vivo, rats were treated with/without lead acetate (PbAc) (0.05%, w/v) in the presence/absence of GSPE (200 mg/kg). In vitro, hepatocytes were pretreated with/without GSPE (100 μg/ml) in the presence/absence of PbAc (100 μM)...
February 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29156292/dietary-luteolin-protects-against-hgcl-2-induced-renal-injury-via-activation-of-nrf2-mediated-signaling-in-rat
#16
Xiao Tan, Biying Liu, Jingjing Lu, Siyu Li, Ruiqi Baiyun, Yueying Lv, Qian Lu, Zhigang Zhang
Luteolin (Lut) belongs to the flavonoid family with various beneficial bioactivities. Here, we investigated whether Lut attenuate mercuric chloride (HgCl2 )-induced renal injury in rat. We found that oral gavage administration of Lut (80mg/kg) alleviated anemia and renal histology upon HgCl2 treatment (80mg/L). Lut also significantly reduced HgCl2 -induced oxidative stress and inflammatory, presenting as the reduced malondialdehyde (MDA) formation, increased glutathione (GSH) level, and inhibited activation of nuclear factor kappa B (NF-κB)...
February 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29153032/evaluation-of-the-carcinogenic-potential-of-roxadustat-fg-4592-a-small-molecule-inhibitor-of-hypoxia-inducible-factor-prolyl-hydroxylase-in-cd-1-mice-and-sprague-dawley-rats
#17
James Beck, Carroll Henschel, James Chou, Al Lin, Ughetta Del Balzo
The carcinogenic potential of roxadustat (FG-4592), a novel orally active, heterocyclic small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) enzymes in clinical development for treatment of anemia, was evaluated in CD-1 mice and Sprague Dawley rats. Inhibition of HIF-PH by roxadustat leads to a rapid increase in cytoplasmic HIF-α concentrations, followed by translocation of HIF-α to the nucleus and upregulation of HIF-responsive genes, including erythropoietin. Roxadustat was dosed by oral gavage 3 times weekly (TIW) for up to 104 weeks in mice at 0, 15, 30, and 60 mg/kg and in rats at 0, 2...
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29078759/endothelin-a-receptor-blocker-and-calcimimetic-in-the-adenine-rat-model-of-chronic-renal-insufficiency
#18
Suvi Törmänen, Ilkka Pörsti, Päivi Lakkisto, Ilkka Tikkanen, Onni Niemelä, Timo Paavonen, Jukka Mustonen, Arttu Eräranta
BACKGROUND: We studied whether endothelin receptor antagonist and calcimimetic treatments influence renal damage and kidney renin-angiotensin (RA) components in adenine-induced chronic renal insufficiency (CRI). METHODS: Male Wistar rats (n = 80) were divided into 5 groups for 12 weeks: control (n = 12), 0.3% adenine (Ade; n = 20), Ade + 50 mg/kg/day sitaxentan (n = 16), Ade + 20 mg/kg/day cinacalcet (n = 16), and Ade + sitaxentan + cinacalcet (n = 16)...
October 27, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29074377/dual-therapeutic-effects-of-an-albumin-based-nitric-oxide-donor-on-2-experimental-models-of-chronic-kidney-disease
#19
Shun Oshiro, Yu Ishima, Hitoshi Maeda, Naoko Honda, Jing Bi, Ryo Kinoshita, Mayumi Ikeda, Yasunori Iwao, Tadashi Imafuku, Kento Nishida, Sigeyuki Miyamura, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Chronic kidney disease (CKD) is accompanied by a variety of complications, typically renal anemia and kidney fibrosis. Accordingly, it is desirable to develop the novel therapeutics that can treat these CKD conditions. Since nitric oxide (NO) has multiple functions including hypoxia inducible factor stabilizing, anti-inflammatory, anti-oxidative, and anti-apoptoic activities, the use of NO for the CKD therapy has attracted considerable interest. Here, we evaluate the therapeutic impacts of S-nitrosated human serum albumin (SNO-HSA), a long-lasting NO donor, on 2 animal models of CKD...
March 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29073196/fgf23-expression-in-rodents-is-directly-induced-via-erythropoietin-after-inhibition-of-hypoxia-inducible-factor-proline-hydroxylase
#20
Ingo Flamme, Peter Ellinghaus, Diana Urrego, Thilo Krüger
Plasma levels of FGF23 are increased in patients with chronic kidney disease. Beside its role in phosphate homeostasis, iron deficiency and anemia are associated with increased FGF23 plasma levels. Recently, FGF23 plasma levels were shown to be increased in mice after treatment with hypoxia inducible factor-proline hydroxylase (HIF-PH) inhibitors which are strong inducers of erythropoietin and erythropoiesis and are known to modulate iron uptake and availability. Therefore we investigated a potential context between expression of FGF23 and stimulation of erythropoiesis using a HIF-PH inhibitor and erythropoietin in rats...
2017: PloS One
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