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Reinhard Told, Agnes Boltz, Leopold Schmetterer, Gerhard Garhöfer, Stefan Sacu, Ursula Schmidt-Erfurth, Andreas Pollreisz
PURPOSE: Spectrophotometric retinal oximetry is a non-invasive technology for measuring oxygen saturation in arterioles and venules (SaO2 , SvO2 ). We compared two commercially available systems: the Oxymap T1 (Oxymap ehf., Reykjavik, Iceland) and the Dynamic Vessel Analyzer (DVA, Imedos, Jena, Germany). METHODS: Twenty healthy adults were included after giving informed consent. Two measurement cycles 30 min apart, including Oxymap T1, DVA, arterialized capillary blood draw of the earlobe (ScO2 ) and peripheral oxygen saturation using finger pulse oximetry (SpO2 ) were scheduled...
February 28, 2018: Acta Ophthalmologica
Irena Šínová, Jiří Řehák, Jana Nekolová, Nad'a Jirásková, Petra Haluzová, Tereza Řeháková, Barbora Bábková, Libor Hejsek, Martin Šín
PURPOSE: To evaluate the relationship between the ischemic index and the oxygen saturation in retinal vessels in patients with retinal vein occlusion. DESIGN: Prospective, cross-sectional study. METHODS: We performed a prospective study. The cohort consisted of 43 eyes of 43 patients with retinal vein occlusions (RVO), 23 of whom had central retinal vein occlusions (CRVO) and 20 who had branch retinal vein occlusions (BRVO). We evaluated the retinal vessel saturation using an automatic retinal oximetry device...
April 2018: American Journal of Ophthalmology
Cheng Li, Xiaoxiao Feng, Xin Wen, Xiaobing Qian, Qishan Zheng, Yongguang Yuan, Yue Fu, Wanwen Shao, Yujie Li, Xiaofeng Lin, Qianying Gao
Purpose: To evaluate the retinal vessel oxygen saturation in central serous chorioretinopathy (CSC) cases among the Chinese. Methods: Relative oxygen saturation of retinal blood vessels was measured in 33 Chinese patients with single-eye CSC using the Oxymap T1 retinal oximeter. The contralateral eyes were the control. The mean saturation of the retinal arteriole (AS) and venule (VS), arteriovenous difference (AVS), and arteriole and venule diameters (AD, VD) was analyzed in the optic disc area and macular region...
2017: Journal of Ophthalmology
Tereza Svrčinová, Jan Mareš, Oldřich Chrapek, Irena Šínová, Martina Rybariková, Pavel Otruba, Petr Kaňovský, Martin Šín
PURPOSE: Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). METHODS: Thirty-two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]...
May 2018: Acta Ophthalmologica
Thomas Lee Torp, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, Jakob Grauslund
BACKGROUND/AIMS: Proliferative diabetic retinopathy (PDR) is a severe blinding condition. We investigated whether retinal metabolism, measured by retinal oximetry, may predict PDR activity after panretinal laser photocoagulation (PRP). METHODS: We performed a prospective, interventional, clinical study of patients with treatment-naive PDR. Wide-field fluorescein angiography (OPTOS, Optomap) and global and focal retinal oximetry (Oxymap T1) were performed at baseline (BL), and 3 months (3M) after PRP...
March 2018: British Journal of Ophthalmology
Yuki Nakano, Koichiro Manabe, Rie Osaka, Yukari Takasago, Aoi Ono, Mamoru Kobayashi, Tomoyoshi Fujita, Chieko Shiragami, Kazuyuki Hirooka, Akitaka Tsujikawa
PURPOSE: To evaluate the effects of vitreomacular and cataract surgery on retinal oximetry in vitreomacular disease. PATIENTS AND METHODS: Thirty-eight eyes with epiretinal membrane (ERM) and 15 with idiopathic macular hole (MH) underwent 25 gauge pars plana vitrectomy combined with cataract surgery and intraocular lens implantation. Retinal oximetry was performed using the Oxymap T1 before, 1 month, and 6 months after surgery. Oxymap T1 simultaneously captures monochrome images of the fundus at two different wavelengths of light...
2017: Clinical Ophthalmology
Thorunn Scheving Eliasdottir, David Bragason, Sveinn Hakon Hardarson, Charles Vacchiano, Thorarinn Gislason, Jona Valgerdur Kristjansdottir, Gudrun Kristjansdottir, Einar Stefánsson
BACKGROUND: Determination of the blood oxyhemoglobin saturation in the retinal vessels of the eye can be achieved through spectrophotometric retinal oximetry which provides access to the state of oxyhemoglobin saturation in the central nervous system circulation. The purpose of this study was to test the capability of the Oxymap T1 oximeter to detect systemic hypoxemia and the effect of supplemental oxygen on retinal vessel oxyhemoglobin saturation. METHODS: Oxygen saturation of hemoglobin in retinal arterioles and venules was measured in 11 subjects with severe chronic obstructive pulmonary disease (COPD) on long term oxygen therapy...
2017: PloS One
Jing-Yan Yang, Bing You, Qian Wang, Szy Yann Chan, Jost B Jonas, Wen-Bin Wei
AIM: To measure the retinal oxygen saturation in healthy subjects and early branch retinal vein occlusion (BRVO) in Chinese population. METHODS: The retinal vessel oxygen saturation of the healthy subjects and BRVO patients were measured by a noninvasive retinal oximeter (Oxymap ehf., Reykjavik, Iceland). RESULTS: The study included 22 patients with unilateral BRVO (mean age: 55.1±8.8y) in the study group and 91 healthy participants (mean age: 37...
2017: International Journal of Ophthalmology
Pei Chen, Xiaoxiao Cai, Lijun Xu, Jing Zhang, Ying Yang, Qianying Gao, Jian Ge, Keming Yu, Jing Zhuang
PURPOSE: To determine whether posterior chamber phakic implantable collamer lens (ICL) surgery in high myopia patients impedes oxygen saturation of retinal vessels. METHODS: Mean oxygen saturation and diameter in retinal blood vessels were measured before and after ICL implantation surgery to correct high myopia refractive errors (i.e. -6.00 to -20.25 dioptres [D]), using an Oxymap T1 retinal oximeter. RESULTS: In 17 eyes of 17 patients, the Oxymap T1 retinal oximeter detected a small but significant decrease in oxygen saturation of retinal venules, 1-week postoperatively (compared to preoperative measurements)...
September 2017: Acta Ophthalmologica
Zhu Li Yap, Charles Ong, Yi Fang Lee, Andrew Tsai, Clarissa Cheng, Monisha E Nongpiur, Shamira A Perera
PURPOSE: Although some studies suggest a strong link between retinal vessel oxygenation and damage to the retinal nerve fiber layer (RNFL) seen in glaucoma, it has yet to be conclusively proven. This study compares intraocular retinal oximetry in glaucomatous eyes displaying asymmetrically affected hemifields across different subgroups of glaucoma, namely primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG). METHODS: In this prospective cross-sectional study, 99 patients (PACG, n=28; POAG, n=37; NTG, n=34) underwent retinal oxygenation and vessel caliber measurements using the Oxymap T1 Retinal Oximeter, Cirrus optical coherence tomography, and Humphrey visual field testing...
April 2017: Journal of Glaucoma
Hui Chen, Haotian Lin, Wan Chen, Bo Zhang, Wu Xiang, Qianying Gao, Weirong Chen, Yizhi Liu
PURPOSE: To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS: This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens implantation. The mean retinal arterial and venular oxygen saturation (SO2 ) levels were measured using the Oxymap system prior to, immediately after and 3 months after cataract surgery...
September 2017: Acta Ophthalmologica
Xue Liu, Shuang Wang, Yi Liu, Li Juan Liu, Yan Yun Lv, Ping Tang, Jost B Jonas, Liang Xu
PURPOSE: To study the retinal oxygen saturation in normal eyes of Chinese adolescents. METHODS: Performing retinal oximetry with the Oxymap T1 Retinal Oximeter in healthy children and adolescents (aged 5-18 years old), we measured the arterial (SaO2 ) and venular (SvO2 ) oxygen saturation and the arteriovenous difference in oxygen saturation (Sa-vO2 ). RESULTS: The study included 122 individuals with a mean age of 13.0 ± 2.9 years (range: 5-18 years) and a mean refractive error of -3...
February 2017: Acta Ophthalmologica
Clarissa Shu Ming Cheng, Yi Fang Lee, Charles Ong, Zhu Li Yap, Andrew Tsai, Aditi Mohla, Monisha E Nongpiur, Tin Aung, Shamira A Perera
BACKGROUND: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity. METHODS: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing...
2016: Clinical Ophthalmology
Yuki Nakano, Takeru Shimazaki, Nobuko Kobayashi, Yukiko Miyoshi, Aoi Ono, Mamoru Kobayashi, Chieko Shiragami, Kazuyuki Hirooka, Akitaka Tsujikawa
PURPOSE: To establish the normative database of retinal oximetry using Oxymap T1 in a healthy Japanese population, and study the reproducibility of the measurements in Japanese. METHODS: We measured oxygen saturation in the major retinal vessels with Oxymap T1 in 252 eyes of 252 healthy Japanese subjects. Fundus images acquired using Oxymap T1 were processed using built-in Oxymap Analyzer software. Reproducibility of retinal oximetry was investigated using 20 eyes of 20 healthy subjects...
2016: PloS One
Jing Li, Yiquan Yang, Diya Yang, Xiangxiang Liu, Yunxiao Sun, Shifei Wei, Ningli Wang
OBJECTIVE: To study the normal values of the retinal oxygen saturation in Rhesus monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements. METHODS: Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap, Reykjavik, Iceland) was used to perform oximetry on all subjects. Global arterial (SaO2) and venous oxygen saturation (SvO2), arteriovenous difference in SO2 were measured...
2016: PloS One
Wouter B Vehmeijer, Vigdis Magnusdottir, Thorunn S Eliasdottir, Sveinn Hakon Hardarson, Nicoline E Schalij-Delfos, Einar Stefánsson
PURPOSE: Dual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen metabolism of the retina in infants may provide valuable clues for better understanding and subsequent prevention or treatment of the disease. The measurements of oxygen saturation are obtained with two fundus images simultaneously captured in two different wavelengths of light...
2016: PloS One
Ashwin Mohan, Supriya Dabir, Mathew Kurian, Rohit Shetty, Lavanya Chidambara, Rajesh S Kumar
PURPOSE: To study whether there exists a relationship between retinal nerve fiber layer thickness and oxygen saturation and to identify whether perivascular thickness (pRNFL) or quadrant thickness (qRNFL) has a stronger correlation. METHODS: Patients without any detectable ocular abnormality on complete ophthalmic evaluation underwent non-invasive photo-spectrometric retinal oximetry on the Oxymap T1 retinal oximeter (Oxymap hf, Reykjavik, Iceland) and spectral-domain optical coherence tomography to determine if the pRNFL (Spectralis, Heidelberg, Germany) and the qRNFL (RtVue, Optovue) correlated with the measured light intensities and the calculated retinal oxygen saturations...
September 2016: Current Eye Research
Bingsheng Lou, Zhaohui Yuan, Liwen He, Lixia Lin, Qianying Gao, Xiaofeng Lin
PURPOSE: To evaluate the effects of long-term tamponade with silicone oil on retinal saturation. METHODS: A total of 49 eyes that received tamponade with silicone oil were included. The patients were divided into 3 groups (3-6 months, 6-9 months, and >9 months) according to the duration of silicone oil tamponade. Retinal oximetry was performed using the Oxymap system before and 2 months after silicone oil removal. RESULTS: The mean retinal oxygen saturation before silicone oil removal was 107% ± 12% in the arterioles and 60% ± 10% in the venules, with an overall arteriovenous difference (AVD) of 47% ± 14%...
2015: BioMed Research International
Martin Šín, Oldřich Chrapek, Marta Karhanová, Irena Šínová, Kareřina Špačková, Kateřina Langová, Jiří Řehák
PURPOSE: To determine the effect of pars plana vitrectomy (PPV) on oxygen saturation in retinal vessels in patients with diabetes and non-diabetes after a 1-year follow-up. METHODS: This was a prospective consecutive interventional case series in 82 eyes in 82 patients. The sample consisted of 25 patients with non-proliferative diabetic retinopathy with macular oedema based on vitreoretinal traction or epiretinal membrane (ERM) and 57 non-diabetic patients with macular hole and ERM...
February 2016: Acta Ophthalmologica
Qishan Zheng, Yao Zong, Li Li, Xia Huang, Leilei Lin, Wei Yang, Yongguang Yuan, Yujie Li, Huining He, Qianying Gao
PURPOSE: To investigate changes in retinal vessel oxygen saturation and diameter in high myopia. METHODS: Relative oxygen saturation was measured in the retinal blood vessels of 54 participants with high myopia and compared to a control group of 54 individuals with emmetropia with the Oxymap T1 retinal oximeter. The participants with high myopia were further divided into two groups according to the grade of myopic retinopathy: Group A (grade < M2 ) and Group B (grade ≥ M2 )...
September 2015: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
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