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Thomas Lee Torp, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, Jakob Grauslund
BACKGROUND/AIMS: Proliferative diabetic retinopathy (PDR) is a severe blinding condition. We investigated whether retinal metabolism, measured by retinal oximetry, may predict PDR activity after panretinal laser photocoagulation (PRP). METHODS: We performed a prospective, interventional, clinical study of patients with treatment-naive PDR. Wide-field fluorescein angiography (OPTOS, Optomap) and global and focal retinal oximetry (Oxymap T1) were performed at baseline (BL), and 3 months (3M) after PRP...
August 1, 2017: British Journal of Ophthalmology
Yuki Nakano, Koichiro Manabe, Rie Osaka, Yukari Takasago, Aoi Ono, Mamoru Kobayashi, Tomoyoshi Fujita, Chieko Shiragami, Kazuyuki Hirooka, Akitaka Tsujikawa
PURPOSE: To evaluate the effects of vitreomacular and cataract surgery on retinal oximetry in vitreomacular disease. PATIENTS AND METHODS: Thirty-eight eyes with epiretinal membrane (ERM) and 15 with idiopathic macular hole (MH) underwent 25 gauge pars plana vitrectomy combined with cataract surgery and intraocular lens implantation. Retinal oximetry was performed using the Oxymap T1 before, 1 month, and 6 months after surgery. Oxymap T1 simultaneously captures monochrome images of the fundus at two different wavelengths of light...
2017: Clinical Ophthalmology
Thorunn Scheving Eliasdottir, David Bragason, Sveinn Hakon Hardarson, Charles Vacchiano, Thorarinn Gislason, Jona Valgerdur Kristjansdottir, Gudrun Kristjansdottir, Einar Stefánsson
BACKGROUND: Determination of the blood oxyhemoglobin saturation in the retinal vessels of the eye can be achieved through spectrophotometric retinal oximetry which provides access to the state of oxyhemoglobin saturation in the central nervous system circulation. The purpose of this study was to test the capability of the Oxymap T1 oximeter to detect systemic hypoxemia and the effect of supplemental oxygen on retinal vessel oxyhemoglobin saturation. METHODS: Oxygen saturation of hemoglobin in retinal arterioles and venules was measured in 11 subjects with severe chronic obstructive pulmonary disease (COPD) on long term oxygen therapy...
2017: PloS One
Jing-Yan Yang, Bing You, Qian Wang, Szy Yann Chan, Jost B Jonas, Wen-Bin Wei
AIM: To measure the retinal oxygen saturation in healthy subjects and early branch retinal vein occlusion (BRVO) in Chinese population. METHODS: The retinal vessel oxygen saturation of the healthy subjects and BRVO patients were measured by a noninvasive retinal oximeter (Oxymap ehf., Reykjavik, Iceland). RESULTS: The study included 22 patients with unilateral BRVO (mean age: 55.1±8.8y) in the study group and 91 healthy participants (mean age: 37...
2017: International Journal of Ophthalmology
Pei Chen, Xiaoxiao Cai, Lijun Xu, Jing Zhang, Ying Yang, Qianying Gao, Jian Ge, Keming Yu, Jing Zhuang
PURPOSE: To determine whether posterior chamber phakic implantable collamer lens (ICL) surgery in high myopia patients impedes oxygen saturation of retinal vessels. METHODS: Mean oxygen saturation and diameter in retinal blood vessels were measured before and after ICL implantation surgery to correct high myopia refractive errors (i.e. -6.00 to -20.25 dioptres [D]), using an Oxymap T1 retinal oximeter. RESULTS: In 17 eyes of 17 patients, the Oxymap T1 retinal oximeter detected a small but significant decrease in oxygen saturation of retinal venules, 1-week postoperatively (compared to preoperative measurements)...
February 15, 2017: Acta Ophthalmologica
Zhu Li Yap, Charles Ong, Yi Fang Lee, Andrew Tsai, Clarissa Cheng, Monisha E Nongpiur, Shamira A Perera
PURPOSE: Although some studies suggest a strong link between retinal vessel oxygenation and damage to the retinal nerve fiber layer (RNFL) seen in glaucoma, it has yet to be conclusively proven. This study compares intraocular retinal oximetry in glaucomatous eyes displaying asymmetrically affected hemifields across different subgroups of glaucoma, namely primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG). METHODS: In this prospective cross-sectional study, 99 patients (PACG, n=28; POAG, n=37; NTG, n=34) underwent retinal oxygenation and vessel caliber measurements using the Oxymap T1 Retinal Oximeter, Cirrus optical coherence tomography, and Humphrey visual field testing...
January 10, 2017: Journal of Glaucoma
Hui Chen, Haotian Lin, Wan Chen, Bo Zhang, Wu Xiang, Qianying Gao, Weirong Chen, Yizhi Liu
PURPOSE: To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS: This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens implantation. The mean retinal arterial and venular oxygen saturation (SO2 ) levels were measured using the Oxymap system prior to, immediately after and 3 months after cataract surgery...
November 19, 2016: Acta Ophthalmologica
Xue Liu, Shuang Wang, Yi Liu, Li Juan Liu, Yan Yun Lv, Ping Tang, Jost B Jonas, Liang Xu
PURPOSE: To study the retinal oxygen saturation in normal eyes of Chinese adolescents. METHODS: Performing retinal oximetry with the Oxymap T1 Retinal Oximeter in healthy children and adolescents (aged 5-18 years old), we measured the arterial (SaO2 ) and venular (SvO2 ) oxygen saturation and the arteriovenous difference in oxygen saturation (Sa-vO2 ). RESULTS: The study included 122 individuals with a mean age of 13.0 ± 2.9 years (range: 5-18 years) and a mean refractive error of -3...
February 2017: Acta Ophthalmologica
Clarissa Shu Ming Cheng, Yi Fang Lee, Charles Ong, Zhu Li Yap, Andrew Tsai, Aditi Mohla, Monisha E Nongpiur, Tin Aung, Shamira A Perera
BACKGROUND: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity. METHODS: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing...
2016: Clinical Ophthalmology
Yuki Nakano, Takeru Shimazaki, Nobuko Kobayashi, Yukiko Miyoshi, Aoi Ono, Mamoru Kobayashi, Chieko Shiragami, Kazuyuki Hirooka, Akitaka Tsujikawa
PURPOSE: To establish the normative database of retinal oximetry using Oxymap T1 in a healthy Japanese population, and study the reproducibility of the measurements in Japanese. METHODS: We measured oxygen saturation in the major retinal vessels with Oxymap T1 in 252 eyes of 252 healthy Japanese subjects. Fundus images acquired using Oxymap T1 were processed using built-in Oxymap Analyzer software. Reproducibility of retinal oximetry was investigated using 20 eyes of 20 healthy subjects...
2016: PloS One
Jing Li, Yiquan Yang, Diya Yang, Xiangxiang Liu, Yunxiao Sun, Shifei Wei, Ningli Wang
OBJECTIVE: To study the normal values of the retinal oxygen saturation in Rhesus monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements. METHODS: Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap, Reykjavik, Iceland) was used to perform oximetry on all subjects. Global arterial (SaO2) and venous oxygen saturation (SvO2), arteriovenous difference in SO2 were measured...
2016: PloS One
Wouter B Vehmeijer, Vigdis Magnusdottir, Thorunn S Eliasdottir, Sveinn Hakon Hardarson, Nicoline E Schalij-Delfos, Einar Stefánsson
PURPOSE: Dual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen metabolism of the retina in infants may provide valuable clues for better understanding and subsequent prevention or treatment of the disease. The measurements of oxygen saturation are obtained with two fundus images simultaneously captured in two different wavelengths of light...
2016: PloS One
Ashwin Mohan, Supriya Dabir, Mathew Kurian, Rohit Shetty, Lavanya Chidambara, Rajesh S Kumar
PURPOSE: To study whether there exists a relationship between retinal nerve fiber layer thickness and oxygen saturation and to identify whether perivascular thickness (pRNFL) or quadrant thickness (qRNFL) has a stronger correlation. METHODS: Patients without any detectable ocular abnormality on complete ophthalmic evaluation underwent non-invasive photo-spectrometric retinal oximetry on the Oxymap T1 retinal oximeter (Oxymap hf, Reykjavik, Iceland) and spectral-domain optical coherence tomography to determine if the pRNFL (Spectralis, Heidelberg, Germany) and the qRNFL (RtVue, Optovue) correlated with the measured light intensities and the calculated retinal oxygen saturations...
September 2016: Current Eye Research
Bingsheng Lou, Zhaohui Yuan, Liwen He, Lixia Lin, Qianying Gao, Xiaofeng Lin
PURPOSE: To evaluate the effects of long-term tamponade with silicone oil on retinal saturation. METHODS: A total of 49 eyes that received tamponade with silicone oil were included. The patients were divided into 3 groups (3-6 months, 6-9 months, and >9 months) according to the duration of silicone oil tamponade. Retinal oximetry was performed using the Oxymap system before and 2 months after silicone oil removal. RESULTS: The mean retinal oxygen saturation before silicone oil removal was 107% ± 12% in the arterioles and 60% ± 10% in the venules, with an overall arteriovenous difference (AVD) of 47% ± 14%...
2015: BioMed Research International
Martin Šín, Oldřich Chrapek, Marta Karhanová, Irena Šínová, Kareřina Špačková, Kateřina Langová, Jiří Řehák
PURPOSE: To determine the effect of pars plana vitrectomy (PPV) on oxygen saturation in retinal vessels in patients with diabetes and non-diabetes after a 1-year follow-up. METHODS: This was a prospective consecutive interventional case series in 82 eyes in 82 patients. The sample consisted of 25 patients with non-proliferative diabetic retinopathy with macular oedema based on vitreoretinal traction or epiretinal membrane (ERM) and 57 non-diabetic patients with macular hole and ERM...
February 2016: Acta Ophthalmologica
Qishan Zheng, Yao Zong, Li Li, Xia Huang, Leilei Lin, Wei Yang, Yongguang Yuan, Yujie Li, Huining He, Qianying Gao
PURPOSE: To investigate changes in retinal vessel oxygen saturation and diameter in high myopia. METHODS: Relative oxygen saturation was measured in the retinal blood vessels of 54 participants with high myopia and compared to a control group of 54 individuals with emmetropia with the Oxymap T1 retinal oximeter. The participants with high myopia were further divided into two groups according to the grade of myopic retinopathy: Group A (grade < M2 ) and Group B (grade ≥ M2 )...
September 2015: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
Olof Birna Olafsdottir, Thorunn Scheving Eliasdottir, Jona Valgerdur Kristjansdottir, Sveinn Hakon Hardarson, Einar Stefánsson
PURPOSE: To detect how systemic hyperoxia affects oxygen saturation in retinal arterioles and venules in healthy individuals. METHODS: Retinal vessel oxygen saturation was measured in 30 healthy individuals with a spectrophotometric retinal oximeter (Oxymap T1). Oximetry was performed during breathing of room air, 100% oxygen (10 minutes, 6L/min) and then again room air (10 minutes recovery). RESULTS: Mean oxygen saturation rises modestly in retinal arterioles during 100% oxygen breathing (94...
2015: PloS One
Rajani Battu, Ashwin Mohan, Anjani Khanna, Abhinav Kumar, Rohit Shetty
PURPOSE: To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS: In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retinal oximeter. The images were analyzed for oxygen saturation and diameter of retinal vessels. RESULTS: All parameters showed a significant difference among the three groups...
May 2015: Investigative Ophthalmology & Visual Science
Yao Zong, Leilei Lin, Changxian Yi, Xia Huang, Yue Fu, Yanmin Dong, Xiaobing Qian, Yujie Li, Qianying Gao
PURPOSE: This study was conducted to determine whether oxygen saturation and retinal blood vessel diameter are affected by retinitis pigmentosa (RP) at various ages. METHODS: Relative oxygen saturation was measured in retinal blood vessels in 68 RP patients and 136 normal subjects using the Oxymap T1 retinal oximeter. Subjects were divided into two age groups: Group A (20-40 years) and Group B (> 40 years). One randomly selected eye of each subject was used for statistical analysis...
February 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Ashwin Mohan, Supriya Dabir, Naresh Kumar Yadav, Matthew Kummelil, Rajesh S Kumar, Rohit Shetty
OBJECTIVE: To study the oxygen saturation profile in normal Asian Indian eyes. DESIGN: A cross sectional prospective study. SUBJECTS: Ninety eight consecutive patients presenting to our hospital with best corrected distance visual acuity (BCVA) of 20/20 and a normal ophthalmic examination were included in the study. Patients having any ocular or systemic disease were excluded from the study. MATERIALS AND METHODS: Oximetry was performed on all subjects with the Oxymap T1 retinal oximeter (Oxymap hf, Reykjavik, Iceland)...
2015: PloS One
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