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Ji-Bin Zhang, Li-Rong Zhao, Tian-Xiang Cui, Xie-Wan Chen, Qiao Yang, Yi-Bing Zhou, Zheng-Tang Chen, Shao-Xiang Zhang, Jian-Guo Sun
The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reconstructed MLNs and original chest computed tomography (CT) images was conducted in the Eclipse™ treatment planning system (TPS). There were three plans, including 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT), which were designed based on 10 cases of simulated lung lesions (SLLs) and MLNs...
April 2018: Oncology Letters
Todd M Olszewski
This article examines the history and effect of the Consensus Development Program (CDP) at the National Institutes of Health (NIH). Introduced at a time when the relationship between the U.S. public and the medical profession was at a nadir, the CDP frequently placed the NIH in the middle of broader debates in medical practice and health policy during the last quarter of the 20th century. Drawing on published and archival sources, this paper sheds light on the challenges associated with collecting, assessing, and communicating evidence to medical professionals and convincing them to act on it in the name of improved health care...
March 20, 2018: Annals of Internal Medicine
Shilpa B Gaikwad, Eric G Johnson, Todd C Nelson, Oluwaseun I Ambode, Abdulaziz A Albalwi, Ahmad A Alharbi, Noha S Daher
BACKGROUND AND PURPOSE: Motion sensitivity is a common condition among the general population and may be accompanied by postural instability and anxiety. Preliminary studies suggest that minimal dosage of gaze stability exercises improves postural stability in young adults with chronic motion sensitivity. The aim of this study was to investigate the effect of progressive gaze stability exercises on postural stability, motion sensitivity, and anxiety in healthy young adults with chronic motion sensitivity...
April 2018: Journal of Neurologic Physical Therapy: JNPT
Simon Boecker, Stefan Grätz, Dennis Kerwat, Lutz Adam, David Schirmer, Lennart Richter, Tabea Schütze, Daniel Petras, Roderich D Süssmuth, Vera Meyer
Background: Fungal cyclodepsipeptides (CDPs) are non-ribosomally synthesized peptides produced by a variety of filamentous fungi and are of interest to the pharmaceutical industry due to their anticancer, antimicrobial and anthelmintic bioactivities. However, both chemical synthesis and isolation of CDPs from their natural producers are limited due to high costs and comparatively low yields. These challenges might be overcome by heterologous expression of the respective CDP-synthesizing genes in a suitable fungal host...
2018: Fungal Biology and Biotechnology
Yasuhiro Horibata, Orly Elpeleg, Ayelet Eran, Yoshio Hirabayashi, David Savitzki, Galit Tal, Hanna Mandel, Hiroyuki Sugimoto
Ethanolamine phosphotransferase 1 (EPT1), also known as selenoprotein 1 (SELENOI), is an enzyme that transfers phosphoethanolamine from cytidine diphosphate (CDP)-ethanolamine to lipid acceptors to produce ethanolamine glycerophospholipids such as diacyl-linked phosphatidylethanolamine (PE) and ether-linked plasmalogen (plasmenyl-PE). However, to date there has been no analysis of the metabolomic consequence of the mutation of EPT1 on the concentration of ethanolamine glycerophospholipids in mammalian cells...
March 2, 2018: Journal of Lipid Research
Celia Bórquez, Ismelda Lobato, Paola Gazmuri, Romina Hurtado, Valerie Llanqui, Mauricio Vivanco, Teresa Reyes, Hilda Villanueva, Katherine Salgado, M Angélica Martínez, Juan Vega
BACKGROUND: The risk groups for sexual transmitted diseases (STDs) are sex workers, drug addicts, young people in early sexual initiation, and population in prison. AIM: To determine the prevalence of HIV, Treponema pallidum and hepatitis B Virus (HBV) in male inmates at the Preventive Detention Center (CDP) of Arica. METHODS: The study was conducted in 140 inmates, with informed consent. Epidemiological survey and blood sampling was conducted...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Lingying Tong, Shiyong Wu
Carnosol is a natural compound extracted from rosemary and sage, which has been demonstrated to have anti-inflammatory, anti-oxidant, and anti-cancer properties. In this report, we evaluated the therapeutic potential and elucidated the potential mechanism of action of carnosol in chemoprevention of ultraviolet B-light (UVB) induced non-melanoma skin cancer formation. Our data indicated that carnosol could partially reduce UVB-induced reactive oxygen species (ROS) elevation and thus reduce DNA damage. It could also reduce UVB-induced formation of cyclobutane pyrimidine dimers (CDP) in keratinocytes possibly through its ability in absorbing UVB radiation...
February 23, 2018: Scientific Reports
Leon Maser, Jan Herritsch, Robert Langer
The reactivity patterns of carbodiphosphoranes (CDPs) as ligands are much less explored than those of isoelectronic analogues. In the current manuscript, we investigate the reactivity of the carbodiphosphorane-based PCP nickel(ii) pincer complex [({dppm}2 C)NiCl]Cl (1) towards acids and bases, calculate proton affinities, analyse the bonding situation and tautomeric forms with the aim to evaluate whether CDPs can potentially act as cooperative ligands in catalysis (dppm = 1,1-bis(diphenylphosphino)methane)...
February 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Edward J Brignole, Kuang-Lei Tsai, Johnathan Chittuluru, Haoran Li, Yimon Aye, Pawel A Penczek, JoAnne Stubbe, Catherine L Drennan, Francisco Asturias
Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resolution structure by cryo-electron microscopy (EM) of a dATP-inhibited state of human RNR. This structure, which was determined in the presence of substrate CDP and allosteric regulators ATP and dATP, has three α2 units arranged in an α6 ring...
February 20, 2018: ELife
Chitu Iulia, Tudosescu Ruxandra, Leasu-Branet Costin, Voinea Liliana-Mary
Citicoline is the generic name of cytidine-5'-diphosphocholine (CDP-choline), an endogenous compound that is able to increase the levels of neurotransmitters in the central nervous system by interacting with the synthesis of cellular membranes phospholipids, especially phosphatidylcholine. Exogenous Citicoline, administered by ingestion or injection, is hydrolyzed and dephosphorylated in order to form cytidine and choline, which resynthesize CDP-choline inside brain cells. It has proven neuroprotective effects in Alzheimer disease, stroke, and Parkinson's disease, as well as in glaucoma and amblyopia...
July 2017: Romanian Journal of Ophthalmology
Jian Liu, Yanmei Yang, Jinwei Bai, Huang Wen, Fengjuan Chen, Baodui Wang
A reasonable and efficient strategy for the construction of hyper-crosslinked porous MoS2-CD-polymer frameworks (MoS2CDPFs) was demonstrated. Here, MoS2 nanosheets (NSs) can be decorated with amino functionalized β-Cyclodextrin, giving rise to a nanoscale structural motif (MoS2@CD) for the synthesis of MoS2CDPFs. We demonstrated that CD polymer (CDP) can be acted as linker and uniformly incorporated into the frameworks. In addition to the pores created between MoS2 NSs, polymer doping generates extra interspace between MoS2 NSs and CD monomer...
February 15, 2018: Analytical Chemistry
Chenjun Li, Max J Klemes, William R Dichtel, Damian E Helbling
In this study, we evaluated the performance of a novel tetrafluoroterephthalonitrile-crosslinked β-cyclodextrin polymer (TFN-CDP) as a solid-phase extraction (SPE) material for the recovery of up to 189 diverse organic micropollutants (MPs) from water. The optimized extraction procedure requires loading of water samples adjusted to a pH of 3 onto 500 mg of TFN-CDP packed into an SPE cartridge. Under these conditions, 88.7% of the MPs have average extraction efficiencies greater than 80%. The optimized recovery procedure requires elution with 15 mL of methanol amended with 15 mg of calcium chloride...
February 6, 2018: Journal of Chromatography. A
Kartikeya Tiwari, Vikash Kumar Dubey
The trypanosomatid parasites continue their killing spree resulting in significant annual mortality due to the lack of effective treatments and the prominence of these diseases in poorer countries. These dimorphic parasites thrive unchecked in the host system, outsmarting the immune mechanisms. An understanding of biology of these parasitic forms will help in the management and elimination of these fatal diseases. Investigation of various metabolic pathways in these parasites has shed light in the understanding of the unique biology of the trypansomatids...
February 8, 2018: Parasites & Vectors
Zehua Gao, Xiaogang Chen, Yuancun Zhao, Xiaohong Zhao, Shu Zhang, Yiwen Yang, Yufang Wang, Ji Zhang
Current research focusing on forensic personal identification, phenotype inference and ancestry information on single-nucleotide polymorphisms (SNPs) has been widely reported. In the present study, we focused on tetra-allelic SNPs in the Chinese Han population. A total of 48 tetra-allelic SNPs were screened out from the Chinese Han population of the 1000 Genomes Database, including Chinese Han in Beijing (CHB) and Chinese Han South (CHS). Considering the forensic genetic requirement for the polymorphisms, only 11 tetra-allelic SNPs with a heterozygosity >0...
January 31, 2018: Forensic Science International. Genetics
Peggy R Trueblood, Monica Rivera, Christian Lopez, Carolyn Bentley, Nancy Wubenhorst
BACKGROUND: Computerized dynamic posturography (CDP) is the gold standard to differentiate between sensory, motor, and central adaptive impairments to postural control. OBJECTIVE: To obtain normative values in healthy adults age 20-69 for a CDP system that uses a full-field dynamic visual surround. This is in contrast to the mechanically movable visual surround used in traditional CDP systems. METHODS: Fifty healthy adults divided into five age groups were tested during the three test protocols for CDP: sensory organization test (SOT), motor control test (MCT), and adaptation test (ADT)...
February 1, 2018: Acta Oto-laryngologica
Junzhi Wang, Cheng Zheng, Yang Cao, Zhuotao Tan, Dong Liu, Zhuopei Cheng, Hanjie Ying, Huanqing Niu
Salt accumulation often impedes cytidine diphosphate choline (CDP-choline)in vitro biosynthetic process. In this work a halotolerant in vitroenzymatic system was developed to solve this problem. It applies a halotolerant choline-phosphate cytidylyltransferase (CCT) obtained from rational design instructed by a unique stagey, which refers to one of the features of naturally occurring halophilic enzymes. By increasing acidic residues on protein surface where is most variable with respect to amino acid in the sequence alignment with other choline-phosphate cytidylyltransferase, the mutants were obtained...
February 1, 2018: Biotechnology Journal
Jeffrey R Hebert, John R Corboy, Timothy Vollmer, Jeri E Forster, Margaret Schenkman
OBJECTIVE: To determine whether a multifaceted vestibular-related rehabilitation program (Balance and Eye-Movement Exercises for Persons with Multiple Sclerosis; BEEMS) improves balance in persons with MS and whether there are differences in outcomes based on brainstem/cerebellar lesion involvement. METHODS: A 2-arm, examiner-blinded, stratified (involvement vs no involvement of brainstem/cerebellar structures), randomized controlled trial was implemented. Eighty-eight participants were allocated to BEEMS or no treatment control...
January 31, 2018: Neurology
Jeffrey R Hebert, Jeri E Forster, Kelly A Stearns-Yoder, Molly E Penzenik, Lisa A Brenner
OBJECTIVE: To investigate linear relationships between dizziness, fatigue, and depression and posttraumatic stress disorder (PTSD) and objectively measured balance performance in Veterans with remote mild traumatic brain injury (mTBI). SETTING: Academic laboratory; Veterans Affairs Medical Center. PARTICIPANTS: Thirty Veterans (28 men) who served in Iraq/Afghanistan and whose most recent mTBI was sustained more than 6 months prior to enrollment...
January 30, 2018: Journal of Head Trauma Rehabilitation
Jan Vazač, Zoltán Füssy, Irena Hladová, Sireesha Killi, Miroslav Oborník
Chromera velia is an alveolate alga which represents the closest known phototrophic relative to apicomplexan parasites. Although the nuclear, mitochondrial, and plastid genomes of this alga have been sequenced, the number of chromosomes and ploidy of C. velia are unknown. We explored ploidy in the vegetative cell, the predominant stage in cultures of Chromera, using the tyramide signal amplification-fluorescence in situ hybridization (TSA-FISH) in isolated nuclei of C. velia. Probes were derived from three single copy genes coding for 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) synthase and Topoisomerase II...
December 18, 2017: Protist
Yifan Chen, Shaolong Shi, Xin Yao, Tadashi Nakano
We propose a new computing-inspired bio-detection framework called touchable computing (TouchComp). Under the rubric of TouchComp, the best solution is the cancer to be detected, the parameter space is the tissue region at high risk of malignancy, and the agents are the nanorobots loaded with contrast medium molecules for tracking purpose. Subsequently, the cancer detection procedure (CDP) can be interpreted from the computational optimization perspective: a population of externally steerable agents (i.e., nanorobots) locate the optimal solution (i...
December 2017: IEEE Transactions on Nanobioscience
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