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https://www.readbyqxmd.com/read/28103007/glutamate-350-plays-an-essential-role-in-conformational-gating-of-long-range-radical-transport-in-e-coli-class-ia-ribonucleotide-reductase
#1
Kanchana R Ravichandran, Ellen C Minnihan, Qinghui Lin, Kenichi Yokoyama, Alexander T Taguchi, Jimin Shao, Daniel G Nocera, JoAnne Stubbe
E. coli Ia ribonucleotide reductase is composed of two subunits that form an active α2β2 complex. The nucleoside diphosphate substrates (NDP) are reduced in α2, 35 Å from the essential diferric-tyrosyl radical (Y122•) cofactor in β2. The Y122• mediated oxidation of C439 in α2 occurs by a pathway (Y122 ↔ [W48] ↔ Y356 in β2 to Y731 ↔ Y730 ↔ C439 in α2) across the α/β interface. The absence of an α2β2 structure precludes insight into the location of Y356 and Y731 at the subunit interface...
January 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28080250/no-evidence-of-disease-activity-in-patients-receiving-daclizumab-versus-intramuscular-interferon-beta-1a-for-relapsing-remitting-multiple-sclerosis-in-the-decide-study
#2
Ludwig Kappos, Eva Havrdova, Gavin Giovannoni, Bhupendra O Khatri, Susan A Gauthier, Steven J Greenberg, Xiaojun You, Ping Wang, Giorgio Giannattasio
BACKGROUND: No evidence of disease activity (NEDA) is a composite endpoint being increasingly applied as an outcome measure in clinical trials as well as proposed for individual therapeutic decisions in multiple sclerosis (MS). OBJECTIVE: Assess the proportion of patients with relapsing-remitting MS achieving NEDA in the DECIDE study of daclizumab 150 mg subcutaneous versus intramuscular interferon beta-1a 30 µg for 96-144 weeks. METHODS: NEDA was defined as no relapses, no onset of 12-week confirmed disability progression (CDP), no new/newly enlarging T2 hyperintense lesions (NET2), and no gadolinium-enhancing (Gd(+)) lesions...
December 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28068088/a-200-mev-uphill-thermodynamic-landscape-for-radical-transport-in-escherichia-coli-ribonucleotide-reductase-determined-using-fluorotyrosine-substituted-enzymes
#3
Kanchana R Ravichandran, Alexander T Taguchi, Yifeng Wei, Cecilia Tommos, Daniel G Nocera, JoAnne Stubbe
Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical (Y122•) in one subunit (β2) generates a transient thiyl radical in another subunit (α2) via long-range radical transport (RT) through aromatic amino acid residues (Y122 ⇆ [W48] ⇆ Y356 in β2 to Y731 ⇆ Y730 ⇆ C439 in α2). Equilibration of Y356•, Y731•, and Y730• was recently observed using site specifically incorporated unnatural tyrosine analogs; however, equilibration between Y122• and Y356• has not been detected...
October 19, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28052917/a-mutation-of-ept1-selenoi-underlies-a-new-disorder-of-kennedy-pathway-phospholipid-biosynthesis
#4
Mustafa Y Ahmed, Aisha Al-Khayat, Fathiya Al-Murshedi, Amna Al-Futaisi, Barry A Chioza, J Pedro Fernandez-Murray, Jay E Self, Claire G Salter, Gaurav V Harlalka, Lettie E Rawlins, Sana Al-Zuhaibi, Faisal Al-Azri, Fatma Al-Rashdi, Amaury Cazenave-Gassiot, Markus R Wenk, Fatema Al-Salmi, Michael A Patton, David L Silver, Emma L Baple, Christopher R McMaster, Andrew H Crosby
Mutations in genes involved in lipid metabolism have increasingly been associated with various subtypes of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative motor neuron disorders characterized by spastic paraparesis. Here, we report an unusual autosomal recessive neurodegenerative condition, best classified as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethanolamine from CDP-ethanolamine...
January 3, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28034297/chemical-classification-of-cyclic-depsipeptides
#5
Lien Taevernier, Evelien Wynendaele, Bert Gevaert, Bart De Spiegeleer
Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of the unusual and non-amino acid building blocks. To date, however, there is no overall uniform chemical classification system available for CDPs and naming of the diverse family members is done rather arbitrarily...
November 28, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28009086/1-2-diacylglycerol-choline-phosphotransferase-catalyzes-the-final-step-in-the-unique-treponema-denticola-phosphatidylcholine-biosynthesis-pathway
#6
Miguel Ángel Vences-Guzmán, M Paula Goetting-Minesky, Ziqiang Guan, Santiago Castillo-Ramirez, Luz América Córdoba-Castro, Isabel M López-Lara, Otto Geiger, Christian Sohlenkamp, J Christopher Fenno
Treponema denticola synthesizes phosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Treponema. However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear. We report here characterization of TDE0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step of the highly conserved Kennedy pathway for phosphatidylcholine synthesis in eukaryotes...
December 23, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27996976/magmas-near-the-critical-degassing-pressure-drive-volcanic-unrest-towards-a-critical-state
#7
Giovanni Chiodini, Antonio Paonita, Alessandro Aiuppa, Antonio Costa, Stefano Caliro, Prospero De Martino, Valerio Acocella, Jean Vandemeulebrouck
During the reawaking of a volcano, magmas migrating through the shallow crust have to pass through hydrothermal fluids and rocks. The resulting magma-hydrothermal interactions are still poorly understood, which impairs the ability to interpret volcano monitoring signals and perform hazard assessments. Here we use the results of physical and volatile saturation models to demonstrate that magmatic volatiles released by decompressing magmas at a critical degassing pressure (CDP) can drive volcanic unrest towards a critical state...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27918366/oculographic-clinical-test-of-sensory-integration-and-balance-and-computerized-dynamic-posturography-findings-in-patients-with-psoriatic-arthritis
#8
Juan Carlos Amor-Dorado, Maria P Barreira-Fernandez, Javier Llorca, Miguel A Gonzalez-Gay
OBJECTIVE: To assess the frequency and characteristics of the oculographic findings and the usefulness of the clinical test of sensory integration and balance (CTSIB) for the evaluation of balance in patients with psoriatic arthritis (PsA) by comparing this test with the computerized dynamic posturography (CDP). STUDY DESIGN: A series of consecutive patients that fulfilled the Moll and Wright criteria for PsA and matched controls were studied. SETTING: The study was performed at the Otolaryngology Division of a tertiary reference center...
December 1, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27900439/non-ribosomal-peptide-synthases-from-pseudomonas-aeruginosa-play-a-role-in-cyclodipeptide-biosynthesis-quorum-sensing-regulation-and-root-development-in-a-plant-host
#9
Omar González, Randy Ortíz-Castro, César Díaz-Pérez, Alma L Díaz-Pérez, Viridiana Magaña-Dueñas, José López-Bucio, Jesús Campos-García
Diverse molecules mediate cross-kingdom communication between bacteria and their eukaryotic partners and determine pathogenic or symbiotic relationships. N-acyl-L-homoserine lactone-dependent quorum-sensing signaling represses the biosynthesis of bacterial cyclodipeptides (CDPs) that act as auxin signal mimics in the host plant Arabidopsis thaliana. In this work, we performed bioinformatics, biochemical, and plant growth analyses to identify non-ribosomal peptide synthase (NRPS) proteins of Pseudomonas aeruginosa, which are involved in CDP synthesis...
November 30, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27895718/consensus-diversity-plots-a-global-diversity-analysis-of-chemical-libraries
#10
Mariana González-Medina, Fernando D Prieto-Martínez, John R Owen, José L Medina-Franco
BACKGROUND: Measuring the structural diversity of compound databases is relevant in drug discovery and many other areas of chemistry. Since molecular diversity depends on molecular representation, comprehensive chemoinformatic analysis of the diversity of libraries uses multiple criteria. For instance, the diversity of the molecular libraries is typically evaluated employing molecular scaffolds, structural fingerprints, and physicochemical properties. However, the assessment with each criterion is analyzed independently and it is not straightforward to provide an evaluation of the "global diversity"...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27892478/continuous-single-cell-imaging-reveals-sequential-steps-of-plasmacytoid-dendritic-cell-development-from-common-dendritic-cell-progenitors
#11
Ezgi Dursun, Max Endele, Andrea Musumeci, Henrik Failmezger, Shu-Hung Wang, Achim Tresch, Timm Schroeder, Anne B Krug
Functionally distinct plasmacytoid and conventional dendritic cells (pDC and cDC) shape innate and adaptive immunity. They are derived from common dendritic cell progenitors (CDPs) in the murine bone marrow, which give rise to CD11c(+) MHCII(-) precursors with early commitment to DC subpopulations. In this study, we dissect pDC development from CDP into an ordered sequence of differentiation events by monitoring the expression of CD11c, MHC class II, Siglec H and CCR9 in CDP cultures by continuous single cell imaging and tracking...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27844416/two-synthetic-methods-for-preparation-of-chiral-stationary-phases-using-crystalline-degradation-products-of-vancomycin-column-performance-for-enantioseparation-of-acidic-and-basic-drugs
#12
Assem Abdollahpour, Rouhollah Heydari, Mojtaba Shamsipur
Two chiral stationary phases (CSPs) based on crystalline degradation products (CDPs) of vancomycin by using different synthetic methods were prepared and compared. Crystalline degradation products of vancomycin were produced by hydrolytic loss of ammonia from vancomycin molecules. Performances of two chiral columns prepared with these degradation products were investigated using several acidic and basic drugs as model analytes. Retention and resolution of these analytes on the prepared columns, as two main parameters, in enantioseparation were studied...
November 14, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27836900/lethal-h1n1-influenza-a-virus-infection-alters-the-murine-alveolar-type-ii-cell-surfactant-lipidome
#13
Parker S Woods, Lauren M Doolittle, Lucia E Rosas, Lisa M Joseph, Edward P Calomeni, Ian C Davis
Alveolar type II (ATII) epithelial cells are the primary site of influenza virus replication in the distal lung. Development of acute respiratory distress syndrome in influenza-infected mice correlates with significant alterations in ATII cell function. However, the impact of infection on ATII cell surfactant lipid metabolism has not been explored. C57BL/6 mice were inoculated intranasally with influenza A/WSN/33 (H1N1) virus (10,000 plaque-forming units/mouse) or mock-infected with virus diluent. ATII cells were isolated by a standard lung digestion protocol at 2 and 6 days postinfection...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27795311/glycerol-phosphate-cytidylyltransferase-stereospecificity-is-key-to-understanding-the-distinct-stereochemical-compositions-of-glycerophosphoinositol-in-bacteria-and-archaea
#14
Marta V Rodrigues, Nuno Borges, Helena Santos
: Glycerophosphoinositol (GPI) is a compatible solute present in a few hyperthermophiles. Interestingly, different GPI stereoisomers accumulate in Bacteria and Archaea, and the basis for this domain-dependent specificity was investigated herein. The archaeon Archaeoglobus fulgidus and the bacterium Aquifex aeolicus were used as model organisms. The synthesis of GPI involves glycerol phosphate cytidylyltransferase (GCT), which catalyzes the production of CDP-glycerol from CTP and glycerol phosphate, and di-myo-inositol phosphate-phosphate synthase (DIPPS), catalyzing the formation of phosphorylated GPI from CDP-glycerol and l-myo-inositol 1-phosphate...
January 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27790243/the-effect-of-spinal-tap-test-on-different-sensory-modalities-of-postural-stability-in-idiopathic-normal-pressure-hydrocephalus
#15
Katrin Abram, Silvia Bohne, Peter Bublak, Panagiota Karvouniari, Carsten M Klingner, Otto W Witte, Orlando Guntinas-Lichius, Hubertus Axer
BACKGROUND/AIMS: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. METHODS: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27787742/-18-f-fluorocholine-pet-ct-imaging-of-liver-cancer-radiopathologic-correlation-with-tissue-phospholipid-profiling
#16
Sandi A Kwee, Miles M Sato, Yu Kuang, Adrian Franke, Laurie Custer, Kyle Miyazaki, Linda L Wong
PURPOSE: [(18)F]fluorocholine PET/CT can detect hepatocellular carcinoma (HCC) based on imaging the initial steps of phosphatidylcholine synthesis. To relate the diagnostic performance of [(18)F]fluorocholine positron emission tomography (PET)/x-ray computed tomography (CT) to the phospholipid composition of liver tumors, radiopathologic correspondence was performed in patients with early-stage liver cancer who had undergone [(18)F]fluorocholine PET/CT before tumor resection. PROCEDURES: Tumor and adjacent liver were profiled by liquid chromatography mass spectrometry, quantifying phosphatidylcholine species by mass-to-charge ratio...
October 27, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27778498/injectable-self-assembled-dipeptide-based-nanocarriers-for-tumor-delivery-and-effective-in-vivo-photodynamic-therapy
#17
Kai Ma, Ruirui Xing, Tifeng Jiao, Guizhi Shen, Chengjun Chen, Junbai Li, Xuehai Yan
Self-assembling peptide-based materials are playing an important role in fabricating drug delivery carriers; however, they are often limited by several challenges, such as precise structure modulation, desirable nanoscale size, and sufficient circulation lifetime in the body. To address this issue, herein one type of injectable dipeptide-based nanocarriers with well-modulated size and structure has been developed by adjusting glutaraldehyde (GA)-assisted cationic dipeptide (CDP) assembly. After loading a model photosensitive drug (Ce6) and further decorating CDP nanoparticles (NPs) with heparin polymers (Hep), the desired dipeptide-based NPs are achieved with an average diameter of 100 nm and surface charge of -25 mV, which are favorable for the enhanced permeability and retention effects...
November 16, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27769579/molecular-structure-and-differential-function-of-choline-kinases-chk%C3%AE-and-chk%C3%AE-in-musculoskeletal-system-and-cancer
#18
Xi Chen, Heng Qiu, Chao Wang, Yu Yuan, Jennifer Tickner, Jiake Xu, Jun Zou
Choline, a hydrophilic cation, has versatile physiological roles throughout the body, including cholinergic neurotransmission, memory consolidation and membrane biosynthesis and metabolism. Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction...
October 8, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27745747/relationship-between-mean-airways-pressure-lung-mechanics-and-right-ventricular-output-during-high-frequency-oscillatory-ventilation-in-infants
#19
Emanuela Zannin, Daniela Doni, Maria Luisa Ventura, Tiziana Fedeli, Camilla Rigotti, Raffaele L Dellacá, Paolo E Tagliabue
OBJECTIVE: To characterize changes in lung mechanics and right ventricular output (RVO) during incremental/decremental continuous distending pressure (CDP) maneuvers in newborn infants receiving high-frequency oscillatory ventilation, with the aim of evaluating when open lung maneuvers are needed and whether they are beneficial. STUDY DESIGN: Thirteen infants on high-frequency oscillatory ventilation were studied with a median (IQR) gestational age of 26(1) (25(3)-29(1)) weeks and median (IQR) body weight of 810 (600-1020) g...
January 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27738720/efficient-multi-enzyme-catalyzed-cdp-choline-production-driven-by-an-atp-donor-module
#20
Yingmiao Liu, Junzhi Wang, Chongmao Xu, Yong Chen, Junjie Yang, Dong Liu, Huanqing Niu, Yu Jiang, Sheng Yang, Hanjie Ying
Cytidine diphosphate choline (CDP-choline) has been applied for treating acute craniocerebral injury and allowing recovery of consciousness after brain surgery. In this study, an acetate kinase (ACK)/acetyl phosphate system was used to supply ATP and combined with Escherichia coli-overexpressed CMP kinase (CMK), NDP kinase (NDK), choline phosphate cytidylyltransferase (CCT), and choline kinase (CKI) to produce CDP-choline from CMP and choline chloride. Within 1 h, 49 mM CDP-choline was produced, for a molar yield of 89...
October 13, 2016: Applied Microbiology and Biotechnology
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