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https://www.readbyqxmd.com/read/27900439/non-ribosomal-peptide-synthases-from-pseudomonas-aeruginosa-play-a-role-in-cyclodipeptide-biosynthesis-quorum-sensing-regulation-and-root-development-in-a-plant-host
#1
Omar González, Randy Ortíz-Castro, César Díaz-Pérez, Alma L Díaz-Pérez, Viridiana Magaña-Dueñas, José López-Bucio, Jesús Campos-García
Diverse molecules mediate cross-kingdom communication between bacteria and their eukaryotic partners and determine pathogenic or symbiotic relationships. N-acyl-L-homoserine lactone-dependent quorum-sensing signaling represses the biosynthesis of bacterial cyclodipeptides (CDPs) that act as auxin signal mimics in the host plant Arabidopsis thaliana. In this work, we performed bioinformatics, biochemical, and plant growth analyses to identify non-ribosomal peptide synthase (NRPS) proteins of Pseudomonas aeruginosa, which are involved in CDP synthesis...
November 30, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27895718/consensus-diversity-plots-a-global-diversity-analysis-of-chemical-libraries
#2
Mariana González-Medina, Fernando D Prieto-Martínez, John R Owen, José L Medina-Franco
BACKGROUND: Measuring the structural diversity of compound databases is relevant in drug discovery and many other areas of chemistry. Since molecular diversity depends on molecular representation, comprehensive chemoinformatic analysis of the diversity of libraries uses multiple criteria. For instance, the diversity of the molecular libraries is typically evaluated employing molecular scaffolds, structural fingerprints, and physicochemical properties. However, the assessment with each criterion is analyzed independently and it is not straightforward to provide an evaluation of the "global diversity"...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27892478/continuous-single-cell-imaging-reveals-sequential-steps-of-plasmacytoid-dendritic-cell-development-from-common-dendritic-cell-progenitors
#3
Ezgi Dursun, Max Endele, Andrea Musumeci, Henrik Failmezger, Shu-Hung Wang, Achim Tresch, Timm Schroeder, Anne B Krug
Functionally distinct plasmacytoid and conventional dendritic cells (pDC and cDC) shape innate and adaptive immunity. They are derived from common dendritic cell progenitors (CDPs) in the murine bone marrow, which give rise to CD11c(+) MHCII(-) precursors with early commitment to DC subpopulations. In this study, we dissect pDC development from CDP into an ordered sequence of differentiation events by monitoring the expression of CD11c, MHC class II, Siglec H and CCR9 in CDP cultures by continuous single cell imaging and tracking...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27844416/two-synthetic-methods-for-preparation-of-chiral-stationary-phases-using-crystalline-degradation-products-of-vancomycin-column-performance-for-enantioseparation-of-acidic-and-basic-drugs
#4
Assem Abdollahpour, Rouhollah Heydari, Mojtaba Shamsipur
Two chiral stationary phases (CSPs) based on crystalline degradation products (CDPs) of vancomycin by using different synthetic methods were prepared and compared. Crystalline degradation products of vancomycin were produced by hydrolytic loss of ammonia from vancomycin molecules. Performances of two chiral columns prepared with these degradation products were investigated using several acidic and basic drugs as model analytes. Retention and resolution of these analytes on the prepared columns, as two main parameters, in enantioseparation were studied...
November 14, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27836900/lethal-h1n1-influenza-a-virus-infection-alters-the-murine-alveolar-type-ii-cell-surfactant-lipidome
#5
Parker S Woods, Lauren May Doolittle, Lucia Elena Rosas, Lisa M Joseph, Edward P Calomeni, Ian Christopher Davis
BACKGROUND: Alveolar type II (ATII) epithelial cells are the primary site of influenza virus replication in the distal lung. Development of acute respiratory distress syndrome (ARDS) in influenza-infected mice correlates with significant alterations in ATII cell function. However, the impact of infection on ATII cell surfactant lipid metabolism has never been explored. METHODS: C57BL/6 mice were inoculated intranasally with 10,000 pfu/mouse of influenza A/WSN/33 (H1N1) or mock-infected with virus diluent...
November 11, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27795311/the-stereospecificity-of-glycerol-phosphate-cytidylyltransferase-is-key-to-understanding-the-distinct-stereochemical-composition-of-glycerophosphoinositol-in-bacteria-and-archaea
#6
Marta V Rodrigues, Nuno Borges, Helena Santos
: Glycerophosphoinositol (GPI) is a compatible solute present in a few hyperthermophiles. Interestingly, different GPI stereoisomers accumulate in Bacteria and Archaea and the basis for this Domain-dependent specificity was investigated herein. The archaeon Archaeoglobus fulgidus and the bacterium Aquifex aeolicus were used as model organisms. The synthesis of GPI involves glycerol-phosphate cytidylyltransferase (GCT), that catalyses the production of CDP-glycerol from CTP and glycerol-phosphate, and di-myo-inositol-phosphate-phosphate synthase (DIPPS), catalyzing the formation of phosphorylated GPI from CDP-glycerol and l-myo-inositol-1-phosphate...
October 21, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27790243/the-effect-of-spinal-tap-test-on-different-sensory-modalities-of-postural-stability-in-idiopathic-normal-pressure-hydrocephalus
#7
Katrin Abram, Silvia Bohne, Peter Bublak, Panagiota Karvouniari, Carsten M Klingner, Otto W Witte, Orlando Guntinas-Lichius, Hubertus Axer
BACKGROUND/AIMS: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. METHODS: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27787742/-18-f-fluorocholine-pet-ct-imaging-of-liver-cancer-radiopathologic-correlation-with-tissue-phospholipid-profiling
#8
Sandi A Kwee, Miles M Sato, Yu Kuang, Adrian Franke, Laurie Custer, Kyle Miyazaki, Linda L Wong
PURPOSE: [(18)F]fluorocholine PET/CT can detect hepatocellular carcinoma (HCC) based on imaging the initial steps of phosphatidylcholine synthesis. To relate the diagnostic performance of [(18)F]fluorocholine positron emission tomography (PET)/x-ray computed tomography (CT) to the phospholipid composition of liver tumors, radiopathologic correspondence was performed in patients with early-stage liver cancer who had undergone [(18)F]fluorocholine PET/CT before tumor resection. PROCEDURES: Tumor and adjacent liver were profiled by liquid chromatography mass spectrometry, quantifying phosphatidylcholine species by mass-to-charge ratio...
October 27, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27778498/injectable-self-assembled-dipeptide-based-nanocarriers-for-tumor-delivery-and-effective-in-vivo-photodynamic-therapy
#9
Kai Ma, Ruirui Xing, Ti-Feng Jiao, Guizhi Shen, Chengjun Chen, Junbai Li, Xuehai Yan
Self-assembling peptide-based materials are playing an important role in fabricating drug delivery carriers, however, they are often limited by several challenges, such as precise structure modulation, desirable nanoscale size and sufficient circulation lifetime in the body. To address this issue, herein one type of injectable dipeptide-based nanocarriers with well-modulated size and structure has been developed by adjusting glutaraldehyde (GA) assisted cationic dipeptide (CDP) assembly. After loading a model photosensitive drug (Ce6) and further decorating CDP nanoparticles (NPs) with heparin polymers (Hep), the desired dipeptide-based NPs are achieved with average diameter of 100 nm and surface charge of -25 mV, which are favorable for the enhanced permeability and retention effects...
October 25, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27769579/molecular-structure-and-differential-function-of-choline-kinases-chk%C3%AE-and-chk%C3%AE-in-musculoskeletal-system-and-cancer
#10
Xi Chen, Heng Qiu, Chao Wang, Yu Yuan, Jennifer Tickner, Jiake Xu, Jun Zou
Choline, a hydrophilic cation, has versatile physiological roles throughout the body, including cholinergic neurotransmission, memory consolidation and membrane biosynthesis and metabolism. Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction...
October 8, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27745747/relationship-between-mean-airways-pressure-lung-mechanics-and-right-ventricular-output-during-high-frequency-oscillatory-ventilation-in-infants
#11
Emanuela Zannin, Daniela Doni, Maria Luisa Ventura, Tiziana Fedeli, Camilla Rigotti, Raffaele L Dellacá, Paolo E Tagliabue
OBJECTIVE: To characterize changes in lung mechanics and right ventricular output (RVO) during incremental/decremental continuous distending pressure (CDP) maneuvers in newborn infants receiving high-frequency oscillatory ventilation, with the aim of evaluating when open lung maneuvers are needed and whether they are beneficial. STUDY DESIGN: Thirteen infants on high-frequency oscillatory ventilation were studied with a median (IQR) gestational age of 26(1) (25(3)-29(1)) weeks and median (IQR) body weight of 810 (600-1020) g...
October 10, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27738720/efficient-multi-enzyme-catalyzed-cdp-choline-production-driven-by-an-atp-donor-module
#12
Yingmiao Liu, Junzhi Wang, Chongmao Xu, Yong Chen, Junjie Yang, Dong Liu, Huanqing Niu, Yu Jiang, Sheng Yang, Hanjie Ying
Cytidine diphosphate choline (CDP-choline) has been applied for treating acute craniocerebral injury and allowing recovery of consciousness after brain surgery. In this study, an acetate kinase (ACK)/acetyl phosphate system was used to supply ATP and combined with Escherichia coli-overexpressed CMP kinase (CMK), NDP kinase (NDK), choline phosphate cytidylyltransferase (CCT), and choline kinase (CKI) to produce CDP-choline from CMP and choline chloride. Within 1 h, 49 mM CDP-choline was produced, for a molar yield of 89...
October 13, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27736218/impact-of-a-community-dental-access-program-on-emergency-dental-admissions-in-rural-maryland
#13
Sandi Rowland, Jonathon P Leider, Clare Davidson, Joanne Brady, Alana Knudson
OBJECTIVES: To characterize the expansion of a community dental access program (CDP) in rural Maryland providing urgent dental care to low-income individuals, as well as the CDP's impact on dental-related visits to a regional emergency department (ED). METHODS: We used de-identified CDP and ED claims data to construct a data set of weekly counts of CDP visits and dental-related ED visits among Maryland adults. A time series model examined the association over time between visits to the CDP and ED visits for fiscal years (FYs) 2011 through 2015...
December 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27687724/crystal-structure-of-the-acid-sphingomyelinase-like-phosphodiesterase-smpdl3b-provides-insights-into-determinants-of-substrate-specificity
#14
Alexei Gorelik, Leonhard X Heinz, Katalin Illes, Giulio Superti-Furga, Bhushan Nagar
The enzyme acid sphingomyelinase-like phosphodiesterase 3B (SMPDL3B) was shown to act as a negative regulator of innate immune signaling, affecting cellular lipid composition and membrane fluidity. Furthermore, several reports identified this enzyme as an off target of the therapeutic antibody rituximab, with implications in kidney disorders. However, structural information for this protein is lacking. Here we present the high resolution crystal structure of murine SMPDL3B, which reveals a substrate binding site strikingly different from its paralogs...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27681634/dual-chromatin-recognition-by-the-histone-deacetylase-complex-hchc-is-required-for-proper-dna-methylation-in-neurospora-crassa
#15
Shinji Honda, Vincent T Bicocca, Jordan D Gessaman, Michael R Rountree, Ayumi Yokoyama, Eun Y Yu, Jeanne M L Selker, Eric U Selker
DNA methylation, heterochromatin protein 1 (HP1), histone H3 lysine 9 (H3K9) methylation, histone deacetylation, and highly repeated sequences are prototypical heterochromatic features, but their interrelationships are not fully understood. Prior work showed that H3K9 methylation directs DNA methylation and histone deacetylation via HP1 in Neurospora crassa and that the histone deacetylase complex HCHC is required for proper DNA methylation. The complex consists of the chromodomain proteins HP1 and chromodomain protein 2 (CDP-2), the histone deacetylase HDA-1, and the AT-hook motif protein CDP-2/HDA-1-associated protein (CHAP)...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27649294/a-200-mev-uphill-thermodynamic-landscape-for-radical-transport-in-escherichia-coli-ribonucleotide-reductase-determined-using-fluorotyrosine-substituted-enzymes
#16
Kanchana R Ravichandran, Alexander T Taguchi, Yifeng Wei, Cecilia Tommos, Daniel G Nocera, JoAnne Stubbe
Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical (Y122•) in one subunit (β2) generates a transient thiyl radical in another subunit (α2) via long-range radical transport (RT) through aromatic amino acid residues (Y122 ⇆ [W48] ⇆ Y356 in β2 to Y731 ⇆ Y730 ⇆ C439 in α2). Equilibration of Y356•, Y731•, and Y730• was recently observed using site specifically incorporated unnatural tyrosine analogs; however, equilibration between Y122• and Y356• has not been detected...
October 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27637449/preliminary-characterizations-antioxidant-and-hepatoprotective-activity-of-polysaccharide-from-cistanche-deserticola
#17
Yuanheng Guo, Lili Cao, Qingsheng Zhao, Lijun Zhang, Jinjin Chen, Boyan Liu, Bing Zhao
To research the preliminary characterizations, antioxidant and hepatoprotective activity of polysaccharides from Cistanche deserticola (CDPs), three polysaccharide fractions, CDP-A, CDP-B and CDP-C, were obtained by successively membrane filtration (microfiltration, ultrafiltration and nanofiltration). Molecular weights, monosaccharide compositions, purities and IR spectra of the three fractions were analyzed. Results showed that CDP-C contained higher proportion of galacturonic acid (GalUA) than CDP-B and CDP-A...
September 13, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27634056/nucleoside-analogue-triphosphates-allosterically-regulate-human-ribonucleotide-reductase-and-identify-chemical-determinants-that-drive-substrate-specificity
#18
Andrew J Knappenberger, Md Faiz Ahmad, Rajesh Viswanathan, Chris G Dealwis, Michael E Harris
Class I ribonucleotide reductase (RR) maintains balanced pools of deoxyribonucleotide substrates for DNA replication by converting ribonucleoside diphosphates (NDPs) to 2'-deoxyribonucleoside diphosphates (dNDPs). Binding of deoxynucleoside triphosphate (dNTP) effectors (ATP/dATP, dGTP, and dTTP) modulates the specificity of class I RR for CDP, UDP, ADP, and GDP substrates. Crystal structures of bacterial and eukaryotic RRs show that dNTP effectors and NDP substrates bind on either side of a flexible nine-amino acid loop (loop 2)...
October 3, 2016: Biochemistry
https://www.readbyqxmd.com/read/27631826/efficacy-of-cdp-and-eng-in-detecting-balance-impairment-associated-with-cerebral-white-matter-changes
#19
Matthew J Urban, Robert T Sataloff
OBJECTIVE: To examine the relationship between white matter changes (WMCs) and abnormal balance test results on computerized dynamic posturography (CDP) and electronystagmography (ENG). Also, to compare the utility of CDP with ENG for this purpose. STUDY DESIGN: Retrospective case review. SETTING: Tertiary care referral center. PATIENTS: A retrospective review of 137 subjects was conducted. The CDP and ENG results were compared between patients with (80) and without (57) WMCs as detected byT2/fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI)...
October 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27613030/immunodepletion-and-immunopurification-as-approaches-for-csn-research
#20
Amnon Golan, Ning Wei, Elah Pick
The COP9 signalosome (CSN) is an evolutionary conserved complex that is found in all eukaryotes, and implicated in regulating the activity of Cullin-RING ubiquitin Ligases (CRLs). Activity of CRLs is highly regulated; complexes are active when the cullin subunit is covalently attached to the ubiquitin like modifier, Nedd8. Neddylation/deneddylation cycles are required for proper CRLs activity, and deneddylation is performed by the CSN complex.We describe here a method utilizing resin-coupled antibodies to deplete the CSN from human cell extracts, and to obtain endogenous CSN complexes by immunopurification...
2016: Methods in Molecular Biology
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