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https://www.readbyqxmd.com/read/28910246/waiting-room-time-an-opportunity-for-parental-oral-health-education
#1
Randa Soussou, Jolanta Aleksejūnienė, Rosamund Harrison
OBJECTIVES: The UBC Children's Dental Program (CDP) has provided free dental treatments to underserved low-income children, but its preventive component needs to be enhanced. The study aims were: 1) to develop a "waiting-room based" dental education program engaging caregivers of these children, and 2) to assess the program's feasibility, acceptability and effectiveness. METHODS: In preparation, a situational analysis (SA) included structured interviews with caregivers, and with various stakeholders (e...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28906301/a-comparative-study-of-lateral-extension-versus-conventional-deltopectoral-flap-in-head-and-neck-reconstruction-after-surgical-extirpation-of-tumor
#2
Mohd Altaf Mir, Mohd Yaseen, Mohd Fahud Khurram
BACKGROUND: We investigated outcomes for nondelayed conventional deltopectoral (CDP) flaps and lateral extension deltopectoral (LEDP) flaps. MATERIAL AND METHODS: Fifteen CDP flaps and 17 LEDP flaps were raised in 32 patients. All flaps were nondelayed. The flaps were folded only in the LEDP flap group. Six of 17 LEDP flaps were folded to become bilayered flaps to repair full thickness defects. Flap success rates and complication rates were compared between the CDP flap and LEDP flap groups...
September 12, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28884894/cdp-choline-circumvents-mercury-induced-mitochondrial-damage-and-renal-dysfunction
#3
Mabel Buelna-Chontal, Martha Franco, Luz Hernández-Esquivel, Natalia Pavón, José S Rodríguez-Zavala, Francisco Correa, Ricardo Jasso, Gregorio Pichardo-Ramos, José Santamaría, Héctor González-Pacheco, Virgilia Soto, Jorge Luis Díaz-Ruíz, Edmundo Chávez
Heavy metal ions are known to produce harmful alterations on kidney function. Specifically, the accumulation of Hg(2+) in kidney tissue may induce renal failure. In this work the protective effect of CDP-choline against the deleterious effects induced by Hg(2+) on renal function were studied. CDP-choline administered ip at a dose of 125 mg/kg body weight prevented the damage induced by Hg(2+) administration at a dose of 3 mg/kg body weight. The findings indicate that CDP-choline guards mitochondria against Hg(2+) -toxicity by preserving their ability to retain matrix content, such as accumulated Ca(2+) ...
September 8, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28861634/novel-one-pot-atp-regeneration-system-based-on-three-enzyme-cascade-for-industrial-ctp-production
#4
Junzhi Wang, Cheng Zheng, Tianyi Zhang, Yingmiao Liu, Zhuopei Cheng, Dong Liu, Hanjie Ying, Huanqing Niu
OBJECTIVES: To develop a new one-pot polyphosphate kinase (PPK) system with low cost and high efficiency for ATP regeneration in industrial CTP production. RESULTS: We developed a new one-pot PPK system by applying a three-enzyme cascade (CMK, NDK and PPK) with an in vitro polyP-based ATP regeneration system. The PPK was selected from twenty sources, and was made solvable by fusion expressing with soluble protein and constructing polycistronic plasmids, or co-expressing with molecular chaperones GroES/EL...
August 31, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28856890/cyclic-dipeptide-based-ambidextrous-supergelators-minimalistic-rational-design-structure-gelation-studies-and-in-situ-hydrogelation
#5
Shivaprasad Manchineella, N Arul Murugan, Thimmaiah Govindaraju
Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic properties. Intermolecular hydrogen bonding, the major driving force for gelation was evaluated using temperature-dependent nuclear magnetic resonance (NMR) spectroscopy. The contribution of attractive van der Waals interaction of tBoc group in driving CDP gelation was ascertained using β-cyclodextrin (β-CD)-adamantane carboxylic acid (AC)-based host-guest gelation and (1)H NMR studies...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28846792/computerized-dynamic-posturography-for-evaluating-dizziness-in-patients-with-scarred-orbital-content
#6
Nathan Shlamkovitch, Ephraim Eviatar, Haim Gavriel
Our objective was to assess the capability of computerized dynamic posturography (CDP) to evaluate dizziness in blind patients who lack corneoretinal potential. We performed a retrospective analysis of 2 young blind subjects with intraorbital scarring who complained of dizziness and underwent CDP. Tests were carried out at our center for balance disorders using the NeuroCom's EquiTest System version 4.0. CDP demonstrated vestibular dysfunction and revealed it to be severe. We conclude that CDP can serve as a potentially reliable tool for assessing dizziness in blind patients who have no corneoretinal potential...
August 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28831632/utilization-of-bioimpedance-spectroscopy-in-the-prevention-of-chronic-breast-cancer-related-lymphedema
#7
David I Kaufman, Chirag Shah, Frank A Vicini, Marisa Rizzi
BACKGROUND: This analysis was performed to assess the impact of early intervention following prospective surveillance using bioimpedance spectroscopy (BIS) to detect and manage breast cancer-related lymphedema (BCRL). METHODS: From 8/2010 to 12/2016, 206 consecutive patients were evaluated with BIS. The protocol included pre-operative assessment with L-Dex as well as post-operative assessments at regular intervals. Patients with L-Dex scores >10 from baseline were considered to have subclinical BCRL and were treated with over-the-counter (OTC) compression sleeve for 4 weeks...
August 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28827025/phosphatidate-phosphatase-regulates-membrane-phospholipid-synthesis-via-phosphatidylserine-synthase
#8
REVIEW
George M Carman, Gil-Soo Han
The yeast Saccharomyces cerevisiae serves as a model eukaryote to elucidate the regulation of lipid metabolism. In exponentially growing yeast, a diverse set of membrane lipids are synthesized from the precursor phosphatidate via the liponucleotide intermediate CDP-diacylglycerol. As cells exhaust nutrients and progress into the stationary phase, phosphatidate is channeled via diacylglycerol to the synthesis of triacylglycerol. The CHO1-encoded phosphatidylserine synthase, which catalyzes the committed step in membrane phospholipid synthesis via CDP-diacylglycerol, and the PAH1-encoded phosphatidate phosphatase, which catalyzes the committed step in triacylglycerol synthesis are regulated throughout cell growth by genetic and biochemical mechanisms to control the balanced synthesis of membrane phospholipids and triacylglycerol...
August 16, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28821141/designed-biocompatible-nano-inhibitor-based-on-poly-%C3%AE-cyclodextrin-ester-for-reduction-of-the-dehp-migration-from-plasticized-pvc
#9
Ahmad Raeisi, Khalil Faghihi, Meisam Shabanian
The easy migration of di(2-ethylhexyl) phthalate (DEHP) from the plasticized PVC (P-PVC) poses a serious threat to human health and the ecosystems. Thus, its control migration from the P-PVC products is very important. In this work, a poly(β-cyclodextrin-ester) network (β-CDP) was synthesized via reaction of β-cyclodextrin with 3,3',4,4'-benzophenone tetracarboxylic dianhydride. As a potential inhibitor for reduction of the DEHP migration, the β-CDP was grafted to Fe3O4 nanoparticles. Poly(β-cyclodextrin-ester) functionalized Fe3O4 nanoparticles (MNP-CDP) has been used in PVC/DEHP system as a reactive nano-inhibitor to reduce DEHP migration...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28818139/bed-rest-and-intermittent-centrifugation-effects-on-human-balance-and-neuromotor-reflexes
#10
William H Paloski, Millard F Reschke, Alan H Feiveson
INTRODUCTION: The effects of repeated centrifugation in association with head-down tilt (HDT) bed rest (BR) on the mediation of basic reflexes associated with the major postural muscles was investigated as a potential countermeasure for maintaining balance control and neuromotor reflex function. METHODS: There were 15 male volunteers who were exposed to 21 d of 6° HDT-BR. Eight were treated with daily 1-h artificial gravity (AG) exposures aboard a short radius centrifuge that provided 1-g footward loading at heart level...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28811757/cyclic-dipeptides-from-bacillus-vallismortis-bs07-require-key-components-of-plant-immunity-to-induce-disease-resistance-in-arabidopsis-against-pseudomonas-infection
#11
Seong Woo Noh, Rira Seo, Jung-Kwon Park, Md Maniruzzaman Manir, Kyungseok Park, Mee Kyung Sang, Surk-Sik Moon, Ho Won Jung
Cyclic dipeptides (CDPs) are one of the simplest compounds produced by living organisms. Plant-growth promoting rhizobacteria (PGPRs) also produce CDPs that can induce disease resistance. Bacillus vallismortis strain BS07 producing various CDPs has been evaluated as a potential biocontrol agent against multiple plant pathogens in chili pepper. However, plant signal pathway triggered by CDPs has not been fully elucidated yet. Here we introduce four CDPs, cyclo(Gly-L-Pro) previously identified from Aspergillus sp...
August 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28799855/surgical-management-of-cervical-spine-deformity-in-chondrodysplasia-punctata
#12
Nobuhito Morota, Satoshi Ihara, Hideki Ogiwara, Goichiro Tamura
OBJECTIVE Chondrodysplasia punctata (CDP), a rare skeletal dysplasia, can lead to cervical spine instability and deformity. However, an optimal neurosurgical intervention has yet to be established. Thus, a retrospective study was conducted to assess the efficacy of various surgical interventions for children with CDP. METHODS The authors retrospectively reviewed 9 cases of CDP in which cervical decompression with or without posterior fusion was performed between April 2007 and May 2016. Patient demographics, preoperative clinical conditions, radiographic findings, surgical procedures, and the postoperative course were analyzed in detail...
August 11, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28760417/cellodextrin-phosphorylase-from-ruminiclostridium-thermocellum-x-ray-crystal-structure-and-substrate-specificity-analysis
#13
Ellis C O'Neill, Giulia Pergolizzi, Clare E M Stevenson, David M Lawson, Sergey A Nepogodiev, Robert A Field
The GH94 glycoside hydrolase cellodextrin phosphorylase (CDP, EC 2.4.1.49) produces cellodextrin oligomers from short β-1→4-glucans and α-D-glucose 1-phosphate. Compared to cellobiose phosphorylase (CBP), which produces cellobiose from glucose and α-D-glucose 1-phosphate, CDP is biochemically less well characterised. Herein, we investigate the donor and acceptor substrate specificity of recombinant CDP from Ruminiclostridium thermocellum and we isolate and characterise a glucosamine addition product to the cellobiose acceptor with the non-natural donor α-D-glucosamine 1-phosphate...
July 21, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28754315/insights-into-the-phosphatidylcholine-and-phosphatidylethanolamine-biosynthetic-pathways-in-leishmania-parasites-and-characterization-of-a-choline-kinase-from-leishmania-infantum
#14
Sergio A Pulido, Victoria H Nguyen, Juan F Alzate, David L Cedeño, Monika A Makurath, Amalia Ríos-Vásquez, Sandra M Duque-Benítez, Marjorie A Jones, Sara M Robledo, Jon A Friesen
The protozoan parasite Leishmania infantum is a causative agent of the disease visceral leishmaniasis, which can be fatal if not properly treated. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthesis pathways are attractive targets for new antileishmanial compounds since these Leishmania cell membrane phospholipids are important for parasite morphology and physiology. In this work we observed Leishmania synthesize PC and PE from extracellular choline and ethanolamine, respectively, suggesting the presence of CDP-choline and CDP-ethanolamine pathways...
November 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28752349/citicoline-in-severe-traumatic-brain-injury-indications-for-improved-outcome-a%C3%A2-retrospective-matched-pair-analysis-from-14%C3%A2-austrian-trauma-centers
#15
Helmut Trimmel, Marek Majdan, Andrea Wodak, Guenther Herzer, Daniel Csomor, Alexandra Brazinova
Goal-oriented management of traumatic brain injury (TBI) can save the lives and/or improve the long-term outcome of millions of affected patients worldwide. Additionally, enhancing quality of life will save enormous socio-economic costs; however, promising TBI treatment strategies with neuroprotective agents, such as citicoline (CDP-choline), lacked evidence or produced contradictory results in clinical trials. During a prehospital TBI project to optimize early TBI care within 14 Austrian trauma centers, data on 778 TBI patients were prospectively collected...
July 27, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28733797/population-genetic-analysis-of-a-21-plex-dip-panel-in-seven-chinese-ethnic-populations
#16
Youjing Jiang, Wang He, Hui Wang, Dan Chen, Xiaogang Bai, Jienan Li, Weibo Liang, Lin Zhang
A 21-plex DIP (deletion and insertion polymorphism) panel has a good performance in analyzing biogeographic ancestry in three main global population groups (European, African, and Asian). This panel was used to investigate 450 unrelated individuals in seven Chinese ethnic groups (Han, Dong, Miao, Zhuang, Uyghur, Tibetan, and Mongolian). Allele frequencies were calculated. Mho (mean value of observed heterozygosity) ranged from 0.3019 to 0.4367, MHe (mean value of expected heterozygosity) ranged from 0.31175 to 0...
July 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28732339/aryl-and-alkyl-phosphorus-containing-flame-retardants-induced-mitochondrial-impairment-and-cell-death-in-chinese-hamster-ovary-cho-k1-cells
#17
Chao Huang, Na Li, Shengwu Yuan, Xiaoya Ji, Mei Ma, Kaifeng Rao, Zijian Wang
Phosphorus-containing flame retardants (PFRs) are increasingly in demand worldwide as replacements for brominated flame retardants (BFRs), but insufficient available toxicological information on PFRs makes assessing their health risks challenging. Mitochondria are important targets of various environmental pollutants, and mitochondrial dysfunction may lead to many common diseases. In the present study, mitochondria impairment-related endpoints were measured by a high content screening (HCS) assay for 11 selected non-halogen PFRs in Chinese hamster ovary (CHO-k1) cells...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28687766/biochemical-properties-of-gh94-cellodextrin-phosphorylase-tha_1941-from-a-thermophilic-eubacterium-thermosipho-africanus-tcf52b-with-cellobiose-phosphorylase-activity
#18
Yuanyuan Wu, Guotao Mao, Haiyan Fan, Andong Song, Yi-Heng Percival Zhang, Hongge Chen
A hypothetic gene (THA_1941) encoding a putative cellobiose phosphorylase (CBP) from Thermosipho africanus TCF52B has very low amino acid identities (less than 12%) to all known GH94 enzymes. This gene was cloned and over-expressed in Escherichia coli BL21(DE3). The recombinant protein was hypothesized to be a CBP enzyme and it showed an optimum temperature of 75 °C and an optimum pH of 7.5. Beyond its CBP activity, this enzyme can use cellobiose and long-chain cellodextrins with a degree of polymerization of greater than two as a glucose acceptor, releasing phosphate from glucose 1-phosphate...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680915/comparative-utility-of-disability-progression-measures-in-ppms-analysis-of-the-promise-data-set
#19
Marcus W Koch, Gary R Cutter, Gavin Giovannoni, Bernard M J Uitdehaag, Jerry S Wolinsky, Mat D Davis, Joshua R Steinerman, Volker Knappertz
OBJECTIVE: To assess the comparative utility of disability progression measures in primary progressive MS (PPMS) using the PROMiSe trial data set. METHODS: Data for patients randomized to placebo (n = 316) in the PROMiSe trial were included in this analysis. Disability was assessed using change in single (Expanded Disability Status Scale [EDSS], timed 25-foot walk [T25FW], and 9-hole peg test [9HPT]) and composite disability measures (EDSS/T25FW, EDSS/9HPT, and EDSS/T25FW/9HPT)...
July 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28679537/a-cost-effectiveness-analysis-of-condom-distribution-programmes-for-the-prevention-of-sexually-transmitted-infections-in-england
#20
Susannah Sadler, Jon Tosh, Rebekah Pennington, Andrew Rawdin, Hazel Squires, Carmen Romero, Alastair Fischer, James Chilcott
BACKGROUND: Prevention of sexually transmitted infection (STI) incidence in England is a high priority, particularly among young people, men who have sex with men (MSM) and black ethnic minorities. An economic evaluation of condom distribution programmes (CDPs) to reduce STI transmission is presented. METHODS: An economic model using a Bernoulli process estimated the number of people acquiring an STI as a function of its prevalence, transmission rate, condom use, condom failure rate and number of sexual contacts...
July 5, 2017: Journal of Epidemiology and Community Health
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