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https://www.readbyqxmd.com/read/28645790/vitamin-e-deficiency-during-embryogenesis-in-zebrafish-causes-lasting-metabolic-and-cognitive-impairments-despite-refeeding-adequate-diets
#1
Melissa McDougall, Jaewoo Choi, Lisa Truong, Robert Tanguay, Maret G Traber
Vitamin E (α-tocopherol; VitE) is a lipophilic antioxidant required for normal embryonic development in vertebrates, but the long-term effects of embryonic VitE deficiency, and whether they are ameliorated by feeding VitE-adequate diets, remain unknown. We addressed these questions using a zebrafish (Danio rerio) model of developmental VitE deficiency followed by dietary remediation. Adult zebrafish maintained on VitE-deficient (E-) or sufficient (E+) diets were spawned to obtained E- and E+ embryos, respectively, which we evaluated up to 12 days post-fertilization (dpf)...
June 20, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28640584/spectroscopic-evidence-for-a-h-bond-network-at-y356-located-at-the-subunit-interface-of-active-e-coli-ribonucleotide-reductase
#2
Thomas U Nick, Kanchana R Ravichandran, JoAnne Stubbe, Müge Kasanmascheff, Marina Bennati
The reaction catalyzed by E. coli ribonucleotide reductase (RNR) composed of α and β subunits that form an active α2β2 complex is a paradigm for proton-coupled electron transfer (PCET) processes in biological transformations. β2 contains the diferric tyrosyl radical (Y122•) cofactor that initiates a radical transfer (RT) over 35 Å via a specific pathway of amino acids (Y122• ↔ [W48] ↔ Y356 in β2 to Y731 ↔Y730↔ C439 in α2). Experimental evidence exists for co-linear and orthogonal PCET in α2 and β2 respectively...
June 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28606547/self-assembled-supermolecular-hydrogel-based-on-hydroxyethyl-cellulose-formation-in-vitro-release-and-bacteriostasis-application
#3
Nan Sun, Ting Wang, Xiufeng Yan
Self-assembly of cellulose-based hydrogel is a new supermolecular architecture with potential for biomedical applications. In this study, a novel cellulose-based, supermolecular self-assembled hydrogel (gel-(β)CDP-HEC) was studied, which was based on the host-guest interaction between hydrophobic lauryl side chains grafting on hydroxyethyl cellulose (HECC12) and the cavities in poly(β-cyclodextrin) (β-CDP). The critical concentrations of HECC12 and β-CDP should be both fixed at 30mgmL(-1) by the results of dynamic viscosity, rheological property and swelling ratio...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28603464/reliability-and-validity-of-the-computerized-dynamic-posturography-sensory-organization-test-in-people-with-multiple-sclerosis
#4
Jeffrey R Hebert, Mark M Manago
BACKGROUND: People with multiple sclerosis (MS) frequently have impaired postural control (balance). Psychometric properties of clinical tests of balance for individuals with MS, including the computerized dynamic posturography sensory organization test (CDP-SOT), are poorly understood. This study aimed to determine the reliability and discriminant validity of the CDP-SOT in people with MS. METHODS: The CDP-SOT was performed on 30 participants with MS. A 2-week-interval, repeated-measures (sessions 1 and 2) design was implemented to investigate test-retest reliability of the CDP-SOT and the ability of the CDP-SOT to discriminate between participants with lower versus higher disability...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28596780/katanin-effects-on-dynamics-of-cortical-microtubules-and-mitotic-arrays-in-arabidopsis-thaliana-revealed-by-advanced-live-cell-imaging
#5
George Komis, Ivan Luptovčiak, Miroslav Ovečka, Despina Samakovli, Olga Šamajová, Jozef Šamaj
Katanin is the only microtubule severing protein identified in plants so far. Previous studies have documented its role in regulating cortical microtubule organization during cell growth and morphogenesis. Although, some cell division defects are reported in KATANIN mutants, it is not clear whether or how katanin activity may affect microtubule dynamics in interphase cells, as well as the progression of mitosis and cytokinesis and the orientation of cell division plane (CDP). For this reason, we characterized microtubule organization and dynamics in growing and dividing cotyledon cells of Arabidopsis ktn1-2 mutant devoid of KATANIN 1 activity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28595652/effect-of-cochlear-implant-surgery-on-vestibular-function-meta-analysis-study
#6
REVIEW
Iman Ibrahim, Sabrina Daniela da Silva, Bernard Segal, Anthony Zeitouni
IMPORTANCE: Vestibular disorders have been reported following cochlear implant (CI) surgery, but the literature shows a wide discrepancy in the reported clinical impact. The aim of this meta-analysis is to quantify the effect of CI before and after surgery on the outcomes of vestibular tests, postural stability, and subjective perception of dizziness. OBJECTIVE: To evaluate the effects of CI surgery on vestibular function in adult patients (≥18 years) with sensorineural hearing loss who underwent unilateral or bilateral implantation...
June 8, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28584488/moisture-sorption-desorption-characteristics-and-the-corresponding-thermodynamic-properties-of-carvedilol-phosphate
#7
Ravikiran Allada, Arthanareeswari Maruthapillai, Kamaraj Palanisamy, Praveen Chappa
AIMS: Carvedilol phosphate (CDP) is a nonselective beta-blocker used for the treatment of heart failures and hypertension. In this work, moisture sorption-desorption characteristics and thermodynamic properties of CDP have been investigated. MATERIALS AND METHODS: The isotherms were determined using dynamic vapor sorption analyzer at different humidity conditions (0%-90% relative humidity) and three pharmaceutically relevant temperatures (20°C, 30°C, and 40°C)...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28556664/benchmarking-micropollutant-removal-by-activated-carbon-and-porous-%C3%AE-cyclodextrin-polymers-under-environmentally-relevant-scenarios
#8
Yuhan Ling, Max Justin Klemes, Leilei Xiao, Alaaeddin Alsbaiee, William R Dichtel, Damian E Helbling
The cost-effective and energy-efficient removal of organic micropollutants (MPs) from water and wastewater is challenging. The objective of this research was to evaluate the performance of porous β-cyclodextrin polymers (P-CDP) as adsorbents of MPs in aquatic matrices. Adsorption kinetics and MP removal were measured in batch and flow-through experiments for a mixture of 83 MPs at environmentally relevant concentrations (1 µg L(-1)) and across gradients of pH, ionic strength, and natural organic matter (NOM) concentrations...
May 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28545875/regional-volume-characteristics-of-the-preterm-infant-receiving-first-intention-continuous-positive-airway-pressure
#9
Risha Bhatia, Peter G Davis, David G Tingay
OBJECTIVE: To determine whether applying nasal continuous positive airway pressure (CPAP) using systematic changes in continuous distending pressure (CDP) results in a quasi-static pressure-volume relationship in very preterm infants receiving first intention CPAP in the first 12-18 hours of life. STUDY DESIGN: Twenty infants at <32 weeks' gestation with mild respiratory distress syndrome (RDS) managed exclusively with nasal CPAP had CDP increased from 5 to 8 to 10 cmH2O, and then decreased to 8 cmH2O and returned to baseline CDP...
May 22, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28521701/unexpected-effects-of-acetylcholine-precursors-on-pilocarpine-seizure-induced-neuronal-death
#10
Minwoo Lee, Bo Young Choi, Sang Won Suh
Choline alfoscerate (α-GPC) and Cytidine 5'-diphosphocholine (CDP-Choline) are both acetylcholine precursors and are considered to act as pro-cholinergic nootropic agents. Acetylcholine precursors have also recently found frequent use in the neurology clinic. Stroke and many types of dementia have been shown to respond favorably after treatment with these agents, not only in terms of cognitive dysfunction but also behavioral and psychological symptoms. The primary mechanisms of Acetylcholine precursors are the following: 1) Acetylcholine precursors themselves are used in the biosynthesis of acetylcholine and 2) byproducts like glycerophosphate have protective functions for neuronal phospholipids...
May 18, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28512456/proline-based-cyclic-dipeptides-from-korean-fermented-vegetable-kimchi-and-from-leuconostoc-mesenteroides-lbp-k06-have-activities-against-multidrug-resistant-bacteria
#11
Rui Liu, Andrew H Kim, Min-Kyu Kwak, Sa-Ouk Kang
Lactobacillus plantarum and Leuconostoc mesenteroides play a prominent role as functional starters and predominant isolates in the production of various types of antimicrobial compound-containing fermented foods, especially including kimchi. In the case of the bioactive cyclic dipeptides, their racemic diastereomers inhibitory to bacteria and fungi have been suggested to come solely from Lactobacillus spp. of these strains. We previously demonstrated the antifungal and antiviral activities of proline-based cyclic dipeptides, which were fractionated from culture filtrates of Lb...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28507630/relationship-between-gait-parameters-and-postural-stability-in-early-and-late-parkinson-s-disease-and-visual-feedback-based-balance-training-effects
#12
Mohieldin M Ahmed, Douaa M Mosalem, Aziz K Alfeeli, Ayyoub B Baqer, Doaa Youssry Soliman
BACKGROUND: Gait disorders or postural instability has been done before. However, lack of reviews has addressed the relation between gait and postural stability in Parkinson's disease (PD). AIM: The aim was to evaluate the relation between gait parameters and postural stability in early and late stages of PD. MATERIALS AND METHODS: The forty-one idiopathic PD patients were divided into two groups into a group (A) considered as early PD and group (B) considered as late ambulant PD...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507514/markovian-analysis-of-the-sequential-behavior-of-the-spontaneous-spinal-cord-dorsum-potentials-induced-by-acute-nociceptive-stimulation-in-the-anesthetized-cat
#13
Mario Martin, Javier Béjar, Gennaro Esposito, Diógenes Chávez, Enrique Contreras-Hernández, Silvio Glusman, Ulises Cortés, Pablo Rudomín
In a previous study we developed a Machine Learning procedure for the automatic identification and classification of spontaneous cord dorsum potentials (CDPs). This study further supported the proposal that in the anesthetized cat, the spontaneous CDPs recorded from different lumbar spinal segments are generated by a distributed network of dorsal horn neurons with structured (non-random) patterns of functional connectivity and that these configurations can be changed to other non-random and stable configurations after the noceptive stimulation produced by the intradermic injection of capsaicin in the anesthetized cat...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28499596/magnetic-porous-%C3%AE-cyclodextrin-polymer-for-magnetic-solid-phase-extraction-of-microcystins-from-environmental-water-samples
#14
Wenmin Zhang, Mingxia Lin, Meili Wang, Ping Tong, Qiaomei Lu, Lan Zhang
Microcystins (MCs) are cyclic heptapeptide toxins and tumor promoters produced by cyanobacteria, which threaten the health of humans. In this study, magnetic porous β-cyclodextrin polymer (Fe3O4@SiO2@P-CDP) was synthesized and characterized by transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectrometry, Fourier transform infrared spectrometry, X-ray diffraction, nitrogen adsorption porosimetry and vibrating sample magnetometer. The synthesized Fe3O4@SiO2@P-CDP particles were then used for magnetic solid-phase extraction (MSPE) of MCs from environmental water samples, and exhibited excellent extraction performance, especially for MC-RR...
May 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28475587/two-studies-in-one-a-propensity-score-matched-comparison-of-fingolimod-versus-interferons-and-glatiramer-acetate-using-real-world-data-from-the-independent-german-studies-pangaea-and-pearl
#15
Jonathan Alsop, Jennie Medin, Christian Cornelissen, Stefan Viktor Vormfelde, Tjalf Ziemssen
BACKGROUND: This study compared outcomes following fingolimod or BRACE treatments (beta-interferons/glatiramer acetate) in patients with active MS (≥ 1 relapse in the previous year) following previous BRACE treatment. METHODS AND FINDINGS: Patients with active MS who previously received BRACE were identified from German prospective, observational studies, PANGAEA and PEARL. A novel methodology was developed to compare outcomes between propensity-score-matched cohorts (3:1 ratio) from the independent single-arm studies...
2017: PloS One
https://www.readbyqxmd.com/read/28456351/synthesis-of-novel-chlorhexidine-spheres-with-controlled-release-from-a-udma-hema-resin-using-ultrasound
#16
Dong Luo, Saroash Shahid, Gleb B Sukhorukov, Michael J Cattell
OBJECTIVE: Establish the release kinetics of new chlorhexidine particles incorporated in a dental resin, and with the application of ultrasound. METHODS: Spherical chlorhexidine particles (SCP) were synthesized (5wt%), freeze dried and incorporated into UDMA-HEMA resins. Chlorhexidine diacetate (CDP) (5wt%) was similarly incorporated in separate resins. Resin discs were immersed in deionized water, and a release profile established (650h). Ultrasound was used to trigger chlorhexidine (CHX) release from the resin discs at specific durations (10-30s) and time intervals (1-425h)...
April 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28450894/peginterferon-beta-1a-reduces-disability-worsening-in-relapsing-remitting-multiple-sclerosis-2-year-results-from-advance
#17
Scott D Newsome, Bernd C Kieseier, Shifang Liu, Xiaojun You, Elizabeth Kinter, Serena Hung, Bjoern Sperling
BACKGROUND: In the pivotal phase III 2-year ADVANCE study, subcutaneous peginterferon beta-1a 125 mcg every 2 weeks demonstrated significant improvements in clinical outcomes, including disability endpoints, in patients with relapsing-remitting multiple sclerosis (RRMS). Here, we aim to further evaluate disability data from ADVANCE, and explore associations between confirmed disability progression (CDP), functional status, and health-related quality of life (HRQoL). METHODS: In total, 1512 patients were randomized to placebo or peginterferon beta-1a 125 mcg every 2 or 4 weeks...
January 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#18
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28420658/simple-and-rapid-biochemical-method-to-synthesize-labeled-or-unlabeled-phosphatidylinositol-species
#19
Satu Hänninen, Krishna Chaithanya Batchu, Kati Hokynar, Pentti Somerharju
Phosphatidylinositol (PI) is the precursor of many important signaling molecules in eukaryotic cells and, most probably, PI also has important functions in cellular membranes. However, these functions are poorly understood, which is largely due to that i) only few PI species with specific acyl chains are available commercially and ii) there are no simple methods to synthesize such species. Here, we present a simple biochemical protocol to synthesize a variety of labeled or unlabeled PI species from corresponding commercially available phosphatidylcholines...
June 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28392327/new-liquid-chromatography-tandem-mass-spectrometry-method-for-routine-tdm-of-vancomycin-in-patients-with-both-normal-and-impaired-renal-functions-and-comparison-with-results-of-polarization-fluoroimmunoassay-in-light-of-varying-creatinine-concentrations
#20
Hana Brozmanová, Ivana Kacířová, Romana Uřinovská, Pavel Šištík, Milan Grundmann
A new LC-MS/MS method with simple sample extraction and a relatively short period of vancomycin analysis for routine therapeutic drug monitoring was developed and validated. 50μL serum was precipitated using 20μL 33% trichloroacetic acid and 0.5mol/L NH4OH was added to increase pH before analysis. A RP BEH C18, 1.7μm, 2.1×50mm column maintained at 30°C and tobramycin as internal standard were used. Mass detection was performed in positive electrospray mode. The results obtained with LC-MS/MS method were correlated with an FPIA assay (Abbott AxSYM) using mouse monoclonal antibody...
April 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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