Maria Belland Olsen, Camilla Huse, Mirta Mittelstedt Leal de Sousa, Sarah Louise Murphy, Antonio Sarno, Tobias Sebastian Obermann, Kuan Yang, Jan Cato Holter, Marte Jøntvedt Jørgensen, Erik Egeland Christensen, Wei Wang, Ping Ji, Lars Heggelund, Hedda Hoel, Anne Margarita Dyrhol-Riise, Ida Gregersen, Pål Aukrust, Magnar Bjørås, Bente Halvorsen, Tuva Børresdatter Dahl
PURPOSE: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that hospitalized Covid-19 patients would be characterized by increased levels of oxidative DNA damage and dysregulation of the DNA repair machinery. PATIENTS AND METHODS: Levels of the oxidative DNA lesion 8-oxoG and levels of base excision repair (BER) proteins were measured in peripheral blood mononuclear cells (PBMC) from patients (8-oxoG, n = 22; BER, n = 17) and healthy controls (n = 10) (Cohort 1)...
2022: Journal of Inflammation Research