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Gene expression in peripheral blood cells in response to oxidative stress

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https://www.readbyqxmd.com/read/27902980/gene-expression-profiling-and-functional-characterization-of-macrophages-in-response-to-circulatory-microparticles-produced-during-trypanosoma-cruzi-infection-and-chagas-disease
#1
Imran H Chowdhury, Sue-Jie Koo, Shivali Gupta, Lisa Yi Liang, Bojlul Bahar, Laura Silla, Julio Nuñez-Burgos, Natalia Barrientos, Maria Paola Zago, Nisha Jain Garg
BACKGROUND: Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of clinical disease. METHODS: MPs were harvested from supernatants of human peripheral blood mononuclear cells in vitro incubated with Tc (control: LPS treated), plasma of seropositive humans with a clinically asymptomatic (CA) or symptomatic (CS) disease state (vs...
December 1, 2016: Journal of Innate Immunity
https://www.readbyqxmd.com/read/27899525/reactive-oxygen-species-induce-virus-independent-mavs-oligomerization-in-systemic-lupus-erythematosus
#2
Iwona A Buskiewicz, Theresa Montgomery, Elizabeth C Yasewicz, Sally A Huber, Michael P Murphy, Richard C Hartley, Ryan Kelly, Mary K Crow, Andras Perl, Ralph C Budd, Andreas Koenig
The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)-like helicases during viral infection, was activated by oxidative stress independently of RIG-I helicases. We found that chemically generated oxidative stress stimulated the formation of MAVS oligomers, which led to mitochondrial hyperpolarization and decreased adenosine triphosphate production and spare respiratory capacity, responses that were not observed in similarly treated cells lacking MAVS...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27899146/impact-of-visceral-fat-on-gene-expression-profile-in-peripheral-blood-cells-in-obese-japanese-subjects
#3
Yoshinari Obata, Norikazu Maeda, Yuya Yamada, Koji Yamamoto, Seiji Nakamura, Masaya Yamaoka, Yoshimitsu Tanaka, Shigeki Masuda, Hirofumi Nagao, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Ken-Ichi Matsubara, Yuji Matsuzawa, Iichiro Shimomura
BACKGROUND: Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been reported, but the impact of visceral fat on the gene expression profile in peripheral blood cells remains to be determined. The aim of this study was to determine the effects of visceral fat area (VFA) and subcutaneous fat area (SFA) on the gene expression profile in peripheral blood cells of obese subjects...
November 29, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27669544/comparisons-of-amino-acids-body-constituents-and-antioxidative-response-between-long-time-hd-and-normal-hd
#4
Akira Torigoe, Emiko Sato, Takefumi Mori, Norio Ieiri, Chika Takahashi, Yoko Ishida, Osamu Hotta, Sadayoshi Ito
Introduction Oxidative stress is one of the main mediators of progression of chronic kidney diseases (CKD). Nuclear factor E2-related factor 2 (Nrf2) is the transcription factor of antioxidant and detoxifying enzymes and related proteins which play an important role in cellular defense. Long-time hemodialysis (HD) therapy (8 hours) has been considered to be more beneficial compared to normal HD therapy (4 hours). We investigated oxidative response related to Nrf2 in peripheral blood mononuclear cells (PBMCs) of long-time HD and normal HD patients...
October 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27629807/toxicological-evaluation-of-dextran-stabilized-iron-oxide-nanoparticles-in-human-peripheral-blood-lymphocytes
#5
Sheeja Liza Easo, Parayanthala Valappil Mohanan
Iron oxide nanoparticles present an attractive choice for carcinogenic cell destruction via hyperthermia treatment due to its small size and magnetic susceptibility. Dextran stabilized iron oxide nanoparticles (DIONPs) synthesized and characterized for this purpose were used to evaluate its effect on cellular uptake, cytotoxicity, and oxidative stress response in human peripheral blood lymphocytes. In the absence of efficient internalization and perceptible apoptosis, DIONPs were still capable of inducing significant levels of reactive oxygen species formation shortly after exposure...
December 14, 2016: Biointerphases
https://www.readbyqxmd.com/read/27555763/nrf2-expression-is-increased-in-peripheral-blood-mononuclear-cells-derived-from-mild-moderate-ex-smoker-copd-patients-with-persistent-oxidative-stress
#6
Anna Maria Fratta Pasini, Marcello Ferrari, Chiara Stranieri, Paola Vallerio, Chiara Mozzini, Ulisse Garbin, Giorgia Zambon, Luciano Cominacini
Inadequacy of antioxidant nuclear factor-E2-related factor 2 (Nrf2) and endoplasmic reticulum stress-mediated unfolded protein response has been implicated in severe chronic obstructive pulmonary disease (COPD) and cigarette smoking-induced emphysema. As evidence suggests that the ability to upregulate Nrf2 expression may influence the progression of COPD and no data exist up to now in ex-smokers with mild-moderate COPD, this study was first aimed to evaluate Nrf2 and unfolded protein response expression in peripheral blood mononuclear cells (PBMC) of mild-moderate ex-smokers with COPD compared to smoking habit-matched non-COPD subjects...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27451029/redox-maintenance-and-concerted-modulation-of-gene-expression-and-signaling-pathways-by-a-nanoformulation-of-curcumin-protects-peripheral-blood-mononuclear-cells-against-gamma-radiation
#7
Behrooz Soltani, Nasser Ghaemi, Majid Sadeghizadeh, Farhood Najafi
Exposure to ionizing radiation (IR) could be detrimental to health. Oxidative stress, DNA damage, and inflammation are implicated in radiation damage. Curcumin, a natural polyphenol, has remarkable antioxidant, anti-inflammation and anticarcinogenic properties and is reported to protect cells and organisms against gamma-rays. We have recently enhanced solubility of curcumin via a novel dendrosomal nanoformulation (DNC). The objective of this study was to assess the potential efficacy of this nanoformulation in protecting human peripheral blood mononuclear cells (PBMC) against gamma-radiation...
September 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27019630/hyperglycemia-differentially-affects-maternal-and-fetal-dna-integrity-and-dna-damage-response
#8
Jusciele B Moreli, Janine H Santos, Aline Rodrigues Lorenzon-Ojea, Simone Corrêa-Silva, Rodrigo S Fortunato, Clarissa Ribeiro Rocha, Marilza V Rudge, Débora C Damasceno, Estela Bevilacqua, Iracema M Calderon
OBJECTIVE: Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. METHODS: A total of 144 subjects were divided into 4 groups: normoglycemia (ND; 46 cases), mild gestational hyperglycemia (MGH; 30 cases), gestational diabetes mellitus (GDM; 45 cases) and type-2 diabetes mellitus (DM2; 23 cases). Peripheral blood mononuclear cell (PBMC) isolation and/or leukocytes from whole maternal and umbilical cord blood were obtained from all groups at delivery...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/26861863/mitochondrial-and-oxidative-stress-genes-are-differentially-expressed-in-neutrophils-of-sjia-patients-treated-with-tocilizumab-a-pilot-microarray-study
#9
Ebun Omoyinmi, Raja Hamaoui, Annette Bryant, Mike Chao Jiang, Trin Athigapanich, Despina Eleftheriou, Mike Hubank, Paul Brogan, Patricia Woo
BACKGROUND: Various pathways involved in the pathogenesis of sJIA have been identified through gene expression profiling in peripheral blood mononuclear cells (PBMC), but not in neutrophils. Since neutrophils are important in tissue damage during inflammation, and are elevated as part of the acute phase response, we hypothesised that neutrophil pathways could also be important in the pathogenesis of sJIA. We therefore studied the gene profile in both PBMC and neutrophils of sJIA patients treated with tocilizumab...
February 9, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/26733011/a-randomized-controlled-pilot-study-of-inflammatory-gene-expression-in-response-to-a-stress-management-intervention-for-stem-cell-transplant-caregivers
#10
Mark L Laudenslager, Teresa L Simoneau, Sam Philips, Patrick Benitez, Crystal Natvig, Steve Cole
Few studies have addressed whether stress-associated physiological changes in caregivers are reversible by psychological interventions mitigating distress. We report on pro-inflammatory, sympathetic, and oxidative stress gene expression in response to stress management for caregivers of allogeneic hematopoietic stem cell transplant (Allo-HSCT) patients. Following randomization by permuted block to either treatment as usual (TAU, n = 11) or a stress management intervention (PsychoEducation, Paced Respiration, and Relaxation, PEPRR, n = 13), twenty-four caregivers were selected at the conclusion of a larger trial of 149 caregivers...
April 2016: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/26634271/selective-toxicity-of-investigational-ixazomib-for-human-leukemia-cells-expressing-mutant-cytoplasmic-npm1-role-of-reactive-oxygen-species
#11
Jacqueline S Garcia, Min Huang, Bruno C Medeiros, Beverly S Mitchell
PURPOSE: This study was performed to determine whether the investigational proteasome inhibitor ixazomib demonstrated selective antineoplastic activity against acute myelogenous leukemia cells expressing a mutated nucleophosmin-1 gene and to gain a better understanding of its mechanisms of action. EXPERIMENTAL DESIGN: The cytotoxic effects of ixazomib treatment were analyzed in human acute myelogenous leukemia (AML) cell lines and primary AML samples expressing wild-type or mutated NPM1 (NPMc(+))...
April 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26615753/identification-of-scedosporium-boydii-catalase-a1-gene-a-reactive-oxygen-species-detoxification-factor-highly-expressed-in-response-to-oxidative-stress-and-phagocytic-cells
#12
Sara Mina, Cindy Staerck, Sènan M d'Almeida, Agnès Marot, Yves Delneste, Alphonse Calenda, Julie Tabiasco, Jean-Philippe Bouchara, Maxime J J Fleury
Scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a large variety of infections in both immunocompetent and immunocompromised individuals. This fungus belongs to the Scedosporium apiospermum species complex which usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF). Species of the S. apiospermum complex are able to chronically colonize the CF airways suggesting pathogenic mechanisms allowing persistence and growth of these fungi in the respiratory tract...
December 2015: Fungal Biology
https://www.readbyqxmd.com/read/25956355/metabolic-changes-in-type-2-diabetes-are-reflected-in-peripheral-blood-cells-revealing-aberrant-cytotoxicity-a-viral-signature-and-hypoxia-inducible-factor-activity
#13
Tineke C T M van der Pouw Kraan, Weena J Chen, Mathijs C M Bunck, Daniel H van Raalte, Nynke J van der Zijl, Renate E van Genugten, Liselotte van Bloemendaal, Josefien M Baggen, Erik H Serné, Michaela Diamant, Anton J G Horrevoets
BACKGROUND: Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, dysglycemia, and a pro-atherogenic plasma lipid profile. MetS creates a high risk for development of type 2 diabetes (T2DM) and cardiovascular disease (CVD), presumably by altering inflammatory responses. Presently, it is unknown how the chronic metabolic disturbances in acute hyperglycemia, MetS and T2DM affect the immune activity of peripheral blood cells. METHODS: We performed genome-wide expression analysis of peripheral blood cells obtained from patients with T2DM (n = 6) and age-, sex- , BMI- and blood pressure-matched obese individuals with MetS (n = 4) and lean healthy normoglycemic controls (n = 3), both under fasting conditions and after controlled induction of acute hyperglycemia during a 70 min hyperglycemic clamp...
2015: BMC Medical Genomics
https://www.readbyqxmd.com/read/25927528/genomic-and-clinical-effects-associated-with-a-relaxation-response-mind-body-intervention-in-patients-with-irritable-bowel-syndrome-and-inflammatory-bowel-disease
#14
Braden Kuo, Manoj Bhasin, Jolene Jacquart, Matthew A Scult, Lauren Slipp, Eric Isaac Kagan Riklin, Veronique Lepoutre, Nicole Comosa, Beth-Ann Norton, Allison Dassatti, Jessica Rosenblum, Andrea H Thurler, Brian C Surjanhata, Nicole N Hasheminejad, Leslee Kagan, Ellen Slawsby, Sowmya R Rao, Eric A Macklin, Gregory L Fricchione, Herbert Benson, Towia A Libermann, Joshua Korzenik, John W Denninger
INTRODUCTION: Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) can profoundly affect quality of life and are influenced by stress and resiliency. The impact of mind-body interventions (MBIs) on IBS and IBD patients has not previously been examined. METHODS: Nineteen IBS and 29 IBD patients were enrolled in a 9-week relaxation response based mind-body group intervention (RR-MBI), focusing on elicitation of the RR and cognitive skill building. Symptom questionnaires and inflammatory markers were assessed pre- and post-intervention, and at short-term follow-up...
2015: PloS One
https://www.readbyqxmd.com/read/25904586/no-oxidative-stress-or-dna-damage-in-peripheral-blood-mononuclear-cells-after-exposure-to-particles-from-urban-street-air-in-overweight-elderly
#15
RANDOMIZED CONTROLLED TRIAL
Jette Gjerke Hemmingsen, Kim Jantzen, Peter Møller, Steffen Loft
Exposure to traffic-related particulate matter (PM) has been associated with increased risk of lung disease, cancer and cardiovascular disease especially in elderly and overweight subjects. The proposed mechanisms involve intracellular production of reactive oxygen species (ROS), inflammation and oxidation-induced DNA damage studied mainly in young normal-weight subjects. We performed a controlled cross-over, randomised, single-blinded, repeated-measure study where 60 healthy subjects (25 males and 35 females) with age 55-83 years and body mass index above 25 kg/m(2) were exposed for 5h to either particle-filtered or sham-filtered air from a busy street with number of concentrations and PM2...
September 2015: Mutagenesis
https://www.readbyqxmd.com/read/25575640/immunonutrition-stimulates-immune-functions-and-antioxidant-defense-capacities-of-leukocytes-in-radiochemotherapy-treated-head-neck-and-esophageal-cancer-patients-a-double-blind-randomized-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
J Talvas, G Garrait, N Goncalves-Mendes, J Rouanet, J Vergnaud-Gauduchon, F Kwiatkowski, P Bachmann, C Bouteloup, J Bienvenu, M-P Vasson
BACKGROUND: Immunonutrition has been reported to improve the immune status of perioperative cancer patients, thereby reducing complications and length of hospital stay. AIM: This study aimed to assess whether immunonutrition enriched in arginine, EPA & DHA and nucleotides could impact the immune cells responses in head & neck and esophageal cancer patients treated by radiochemotherapy (RCT). METHODS: A double-blind clinical trial was carried out in 28 patients randomized into two groups, receiving either an immunomodulating enteral nutrition formula (IEN, n = 13, Impact(®), Nestlé) or an isoenergetic isonitrogenous standard enteral nutrition formula (SEN, n = 15) throughout RCT (5-7 weeks)...
October 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25488254/expression-microarray-as-a-tool-to-identify-differentially-expressed-genes-in-horses-suffering-from-inflammatory-airway-disease
#17
Eve Ramery, Audrey Fraipont, Eric A Richard, Tatiana Art, Dimitri Pirottin, Wouter van Delm, Fabrice Bureau, Pierre Lekeux
BACKGROUND: Inflammatory airway disease (IAD) affects performance and well-being of horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology which is invasive and requires sedation. OBJECTIVES: The purpose of this study was to identify differential gene expression in peripheral blood of horses with IAD using species-specific expression microarrays. METHODS: Equine gene expression microarrays were used to investigate global mRNA expression in circulating leukocytes from healthy, IAD-affected, and low-performing Standardbred and endurance horses...
March 2015: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/25487561/short-term-diesel-exhaust-inhalation-in-a-controlled-human-crossover-study-is-associated-with-changes-in-dna-methylation-of-circulating-mononuclear-cells-in-asthmatics
#18
RANDOMIZED CONTROLLED TRIAL
Ruiwei Jiang, Meaghan J Jones, Francesco Sava, Michael S Kobor, Christopher Carlsten
BACKGROUND: Changes in DNA methylation have been associated with traffic-related air pollution in observational studies, but the specific mechanisms and temporal dynamics therein have not been explored in a controlled study of asthmatics. In this study, we investigate short-term effects of diesel exhaust inhalation on DNA methylation levels at CpG sites across the genome in circulating blood in asthmatics. METHODS: A double-blind crossover study of filtered air and diesel exhaust exposures was performed on sixteen non-smoking asthmatic subjects...
2014: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/25484350/the-nrf2-activator-tbhq-inhibits-t-cell-activation-of-primary-human-cd4-t-cells
#19
Alexandra E Turley, Joseph W Zagorski, Cheryl E Rockwell
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates a battery of antioxidant, detoxification, and cell stress genes. It is activated by oxidative stress and a number of exogenous compounds, one of which is tert-butylhydroquinone (tBHQ), a widely used food preservative. Nrf2 modulates immune responses in numerous rodent models of inflammation, but its effects on human immune cells are not well characterized. The purpose of these studies was to evaluate the effects of the Nrf2 activator tBHQ on early events of T cell activation in primary human cells...
February 2015: Cytokine
https://www.readbyqxmd.com/read/25447457/tobacco-smoking-response-genes-in-blood-and-buccal-cells
#20
Hyun-Kyung Na, Minju Kim, Seong-Sil Chang, Soo-Young Kim, Jong Y Park, Myeon Woo Chung, Mihi Yang
Tobacco smoking is a well-known cause of various diseases, however, its toxic mechanisms for diseases are not completely understood, yet. Therefore, we performed biological monitoring to find tobacco smoking-responsive mechanisms including oxidative stress in Korean men (N=36). Whole genome microarray analyses were performed with peripheral blood from smokers and age-matched nonsmokers. We also performed qRT-PCR to confirm the microarray results and compared the gene expression of blood to those of buccal cells...
January 22, 2015: Toxicology Letters
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