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Stereotactic body radiation therapy

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https://www.readbyqxmd.com/read/29771005/prospective-analysis-of-different-combined-regimens-of-stereotactic-body-radiation-therapy-and-chemotherapy-for-locally-advanced-pancreatic-cancer
#1
Xiaofei Zhu, Dongchen Shi, Fuqi Li, Xiaoping Ju, Yangsen Cao, Yuxin Shen, Fei Cao, Shuiwang Qing, Fang Fang, Zhen Jia, Huojun Zhang
To identify impacts of different combined regimens of stereotactic body radiation therapy (SBRT) and chemotherapy on survival of patients with locally advanced pancreatic cancer (LAPC) and factors correlated with determinations of different combinations. Four hundred and nineteen patients with radiographically and biopsy-proven LAPC were prospectively enrolled. Factors associated with different strategies were analyzed with Chi-square test and contingency coefficients. Cox regression was used to identify factors predictive of survival...
May 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29765792/stereotactic-mri-guided-adaptive-radiation-therapy-smart-for-locally-advanced-pancreatic-cancer-a-promising-approach
#2
Elaine Luterstein, Minsong Cao, James Lamb, Ann C Raldow, Daniel A Low, Michael L Steinberg, Percy Lee
Locally advanced pancreatic cancer (LAPC) is characterized by poor prognosis and low response durability with standard-of-care chemotherapy or chemoradiotherapy treatment. Stereotactic body radiation therapy (SBRT), which has a shorter treatment course than conventionally fractionated radiotherapy and allows for better integration with systemic therapy, may confer a survival benefit but is limited by gastrointestinal toxicity. Stereotactic MRI-guided adaptive radiation therapy (SMART) has recently gained attention for its potential to increase treatment precision and thus minimize this toxicity through continuous real-time soft-tissue imaging during radiotherapy...
March 14, 2018: Curēus
https://www.readbyqxmd.com/read/29764593/-stereotactic-body-radiotherapy-for-centrally-located-non-small-cell-lung-cancer
#3
Yuming Wan, Jing Huang, Feng Xu
A few study has proven that about 90% of local control rates might be benefit from stereotactic body radiotherapy (SBRT) for patients with medically inoperable stage I non-small cell lung cancer (NSCLC), it is reported SBRT associated overall survival and tumor specific survival is comparable with those treated with surgery. SBRT has been accepted as the first line treatment for inoperable patients with peripheral located stage I NSCLC. However, the role of SBRT in centrally located lesions is controversial for potential toxic effects from the adjacent anatomical structure...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29764185/management-of-metastatic-spinal-cord-compression-among-veterans-health-administration-radiation-oncologists
#4
Ruchika Gutt, Sheeta Malhotra, Shruti Jolly, Drew Moghanaki, Alice V Cheuk, Helen Fosmire, Maria Kelly, Lori Hoffman-Hogg, Stephen Lutz, Mitchell Anscher, George Dawson
BACKGROUND: Optimal management of metastatic spinal cord compression (MSCC) improves functional outcomes in patients with metastatic disease. This survey study evaluated management of MSCC by Veterans Health Administration (VHA) radiation oncologists (ROs), to determine whether management of MSCC correlates with American College of Radiology (ACR) guidelines, and to compare times to initiation of treatment between surgery and radiotherapy (RT). METHODS: Surveys emailed to 79 VHA ROs included questions on steroid use, surgical care, palliative care, fractionation of irradiation, re-irradiation, and management of common MSCC case scenarios...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29750538/stereotactic-body-radiation-therapy-for-liver-oligometastases-predictive-factors-of-local-response-by-18f-fdg-pet-ct
#5
Rosario Mazzola, Sergio Fersino, Pierpaolo Alongi, Gioacchino Di Paola, Fabiana Gregucci, Dario Aiello, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVE: to investigate metabolic parameters as predictive of local response after Stereotactic Body Radiation Therapy (SBRT) for liver-oligometastases Methods: Inclusion criteria of the present retrospective study were: a) liver oligometastases with controlled primary tumor; b) absence of progressive disease ≥6 months; c) metastases ≤ 3; d) evaluation of SBRT-response by means of 18-FDG-PET/CT for at least two subsequent evaluations; e) Karnofsky performance status >80; f) life-expectancy >6 months...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29749129/plasma-cell-free-dna-as-a-predictive-marker-after-radiotherapy-for-hepatocellular-carcinoma
#6
Sangjoon Park, Eun Jung Lee, Chai Hong Rim, Jinsil Seong
PURPOSE: Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). MATERIALS AND METHODS: Fifty-five patients with HCC who received RT were recruited from two prospective study cohorts: one cohort of 34 patients who underwent conventionally fractionated RT and a second of 21 patients treated with stereotactic body radiation therapy...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29748100/impact-of-magnetic-resonance-imaging-on-gross-tumor-volume-delineation-in-non-spine-bony-metastasis-treated-with-stereotactic-body-radiation-therapy
#7
Srinivas Raman, Lee Chin, Darby Erler, Eshetu G Atenafu, Patrick Cheung, William Chu, Hans Chung, Andrew Loblaw, Ian Poon, Joel Rubenstein, Hany Soliman, Arjun Sahgal, Chia-Lin Tseng
PURPOSE: This study investigates the inter-observer variability of contouring non-spine bone metastases using the planning CT alone vs. the addition of MRI T1 and T2 imaging sequences. METHODS AND MATERIALS: 10 cases of non-spine bone metastases treated with SBRT at our institution were selected. The gross tumor volume (GTV) for each case was delineated by six SBRT radiation oncologists (RO) and one diagnostic radiologist (DR) on the treatment planning CT. After a minimum of three months, each case was re-contoured on the CT fused with a MRI T1 sequence followed by a MRI T2 sequence...
March 17, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29738279/cortical-thinning-and-structural-bone-changes-in-non-human-primates-after-single-fraction-whole-chest-irradiation
#8
Michael Farris, Emory R McTyre, Catherine Okoukoni, Greg Dugan, Brendan J Johnson, A William Blackstock, Michael T Munley, J Daniel Bourland, J Mark Cline, Jeffrey S Willey
Stereotactic body radiation therapy (SBRT) is associated with an increased risk of vertebral compression fracture. While bone is typically considered radiation resistant, fractures frequently occur within the first year of SBRT. The goal of this work was to determine if rapid deterioration of bone occurs in vertebrae after irradiation. Sixteen male rhesus macaque non-human primates (NHPs) were analyzed after whole-chest irradiation to a midplane dose of 10 Gy. Ages at the time of exposure varied from 45-134 months...
May 8, 2018: Radiation Research
https://www.readbyqxmd.com/read/29733909/radiosensitivity-of-lung-metastases-by-primary-histology-and-implications-for-stereotactic-body-radiation-therapy-using-the-genomically-adjusted-radiation-dose
#9
Kamran A Ahmed, Jacob G Scott, John A Arrington, Arash O Naghavi, G Daniel Grass, Bradford A Perez, Jimmy J Caudell, Anders E Berglund, Eric A Welsh, Steven A Eschrich, Thomas J Dilling, Javier F Torres-Roca
INTRODUCTION: We assessed the radiosensitivity of lung metastases based on primary histology using a validated gene signature and model lung metastases for the genomically adjusted radiation dose (GARD). METHODS: Tissue samples were identified from our prospective observational protocol. The radiosensitivity index (RSI) 10 gene assay was run on samples and calculated alongside GARD using the previously published algorithms. A cohort of 105 patients with 137 lung metastases treated with SBRT at our institution was used for clinical correlation...
May 4, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29729781/radiation-for-treatment-of-painful-bone-metastases
#10
REVIEW
Ron Shiloh, Monica Krishnan
Several variables may be considered when deciding on optimal modality of radiation therapy for each cancer patient with bone pain, including prognosis, tumor histology, location and extent of metastases, and association with cord compression. Hypofractionated external beam radiation therapy is as effective as a multiple fraction radiotherapy course in most cases, although retreatment rates are higher after a single dose of radiation. Stereotactic body radiation may be used in cases of oligometastatic disease, repeat irradiation, and radiation-resistant tumors...
June 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29726364/contemporary-statewide-practice-pattern-assessment-of-the-palliative-treatment-of-bone-metastasis
#11
Daniel E Spratt, Brandon R Mancini, James A Hayman, Thomas Boike, Lori J Pierce, Jean M Moran, Michael M Dominello, Mark Fireman, Kent Griffith, Shruti Jolly
PURPOSE: Palliative radiation therapy for bone metastases is often viewed as a single entity, despite national guidelines providing input principally only for painful uncomplicated bone metastases. Data surrounding the treatment of bone metastases are often gleaned from questionnaires of what providers would theoretically do in practice or from population-based data lacking critical granular information. We investigated the real-world treatment of bone metastases with radiation therapy...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29724584/stereotactic-body-radiation-therapy-for-heart-base-tumors-in-six-dogs
#12
L M Magestro, T L Gieger, M W Nolan
INTRODUCTION: Heart-base tumors are increasingly treated with radiotherapy, yet safety and efficacy are incompletely understood. This case series describes outcomes after stereotactic body radiation therapy (SBRT) for presumed chemodectoma. ANIMALS: Six pet dogs. METHODS: A retrospective study was performed, including dogs with a clinical diagnosis of chemodectoma and treatment with three-fraction SBRT (30 Gy total). RESULTS: Heart-base tumors, presumed or confirmed to be chemodectomas, were diagnosed via histopathology or imaging...
April 30, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29724402/thoracic-reirradiation-with-sbrt-for-residual-recurrent-and-new-primary-nsclc-within-or-immediately-adjacent-to-a-prior-high-dose-radiation-field
#13
Zachary D Horne, Michael J Dohopolski, David A Clump, Steven A Burton, Dwight E Heron
PURPOSE: Local failure following concurrent chemoradiation and in-lobe failures following stereotactic body radiation therapy (SBRT) are common. We evaluated our institutional experience using SBRT as salvage in this setting. METHODS AND MATERIALS: Seventy-two patients were reirradiated with SBRT for residual, locally recurrent, or new primary non-small cell lung cancer within or adjacent to a high-dose external beam radiation therapy or SBRT field. Kaplan-Meier analysis with log-rank test were used to estimate endpoints and differentiate cohorts...
May 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29722662/a-retrospective-long-term-follow-up-study-of-stereotactic-body-radiation-therapy-for-non-small-cell-lung-cancer-from-a-single-institution-incidence-of-late-local-recurrence
#14
Takashi Shintani, Yukinori Matsuo, Yusuke Iizuka, Takamasa Mitsuyoshi, Takashi Mizowaki
PURPOSE: To assess the local recurrence (LR) rate and timing after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer using long-term follow-up data from a single institution. METHODS AND MATERIALS: Patients with primary or recurrent non-small cell lung cancer with or without pathologic verification, with tumors <3 cm, treated with SBRT (isocenter prescription of 48 Gy in 4 fractions) between April 1998 and August 2014, and with >6 months' follow-up were eligible...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29721209/radiotherapy-increases-plasma-levels-of-tumoral-cell-free-dna-in-non-small-cell-lung-cancer-patients
#15
Shun-Ichiro Kageyama, Keiji Nihei, Katsuyuki Karasawa, Takeshi Sawada, Fumiaki Koizumi, Shigeo Yamaguchi, Shunsuke Kato, Hidehiro Hojo, Atsuhi Motegi, Katsuya Tsuchihara, Tetsuo Akimoto
We investigated the plasma levels of tumor-specific cell-free DNA (cfDNA) in 17 stage I-II (early) and IV (advanced) non-small cell lung cancer (NSCLC) patients who underwent radiotherapy. Digital polymerase chain reaction (PCR) and targeted sequencing showed that total and tumor-specific cfDNA levels increased in response to radiotherapy in both early- and advanced-stage NSCLC patients. We detected high copy numbers of epidermal growth factor receptor mutations (L858R and T790M) in the cfDNA samples from stage IV NSCLC patients who underwent stereotactic body radiation therapy to treat brain metastasis related to tyrosine kinase inhibitor (TKI) treatment failure...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29715150/image-guided-stereotactic-body-radiotherapy-in-metastatic-prostate-cancer
#16
Francesco Pasqualetti, Marco Panichi, Aldo Sainato, Davide Baldaccini, Paola Cocuzza, Alessandra Gonnelli, Sabrina Montrone, Alessandro Molinari, Sara Barbiero, Andrea Bruschi, Elisa Notini, Stefano Ursino, Valentina Mazzotti, Riccardo Morganti, Gabriele Coraggio, Martina Cantarella, Paola Anna Erba, Fabiola Paiar
BACKGROUND/AIM: In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. MATERIALS AND METHODS: Primary and secondary endpoints of this prospective observational study were local control and safety related to IG-SBRT. All lesions were treated with 24 Gy as a single fraction or 27 Gy in 3 fractions...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29708180/stereotactic-body-radiation-therapy-vs-surgery-in-early-stage-non-small-cell-lung-cancer-lessons-learned-current-recommendations-future-directions
#17
EDITORIAL
Sibo Tian, Kristin A Higgins, Walter J Curran, Richard J Cassidy
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29708155/guidelines-for-stereotactic-body-radiation-therapy-treatment-of-lung-cancer-highlight-important-research-questions-what-is-the-next-step
#18
EDITORIAL
Lorraine D Cornwell, Melissa L Korb, Bryan M Burt
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707354/fiducial-marker-placement-for-stereotactic-body-radiation-therapy-via-convex-probe-endobronchial-ultrasound-a-case-series-and-review-of-literature
#19
REVIEW
Benjamin J Seides, John P Egan, Kim D French, Kevin L Kovitz, Neeraj R Desai
Convex probe endobronchial ultrasound (CP-EBUS) and stereotactic body radiotherapy (SBRT) are valuable tools in the diagnosis, staging, and treatment of thoracic malignancies. With widespread clinical adoption, novel uses of CP-EBUS beyond mediastinal diagnosis and staging continue to be discovered. SBRT is an attractive treatment strategy in early-stage lung cancer and oligo-metastatic disease of the chest when a surgical approach is either not feasible or desirable. Accurate application of SBRT is aided by the placement of radio-opaque fiducial markers (FM) to compensate for respiratory cycle movements...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29706460/local-control-and-fracture-risk-following-stereotactic-body-radiation-therapy-for-non-spine-bone-metastases
#20
Darby Erler, Drew Brotherston, Arjun Sahgal, Patrick Cheung, Andrew Loblaw, William Chu, Hany Soliman, Hans Chung, Alex Kiss, Edward Chow, Ian Poon
AIMS: To report local control and toxicity rates for patients treated with stereotactic body radiotherapy (SBRT) for non-spine bone metastases. METHODS AND MATERIALS: Eighty-one patients with 106 non-spine bone metastases were treated between 2011 and 2014 and retrospectively reviewed. Indications included: oligometastases (63%), oligoprogression (17.3%), retreatment (2.4%) or other (17.3%). Cumulative incidence function was used to assess local recurrence and fracture probability...
April 26, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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