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https://www.readbyqxmd.com/read/29346761/ino80-chromatin-remodeling-coordinates-metabolic-homeostasis-with-cell-division
#1
Graeme J Gowans, Alicia N Schep, Ka Man Wong, Devin A King, William J Greenleaf, Ashby J Morrison
Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression in coordination with respiration and cell division in the yeast metabolic cycle (YMC). Despite the importance of metabolic and proliferative synchrony, the majority of YMC regulators are currently unknown. Here, we demonstrate that the INO80 chromatin-remodeling complex is required to coordinate respiration and cell division with periodic gene expression...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346757/p53-suppresses-metabolic-stress-induced-ferroptosis-in-cancer-cells
#2
Amy Tarangelo, Leslie Magtanong, Kathryn T Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D Attardi, Scott J Dixon
How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensitivity may be modulated by the stress-responsive transcription factor and canonical tumor suppressor protein p53. Using CRISPR/Cas9 genome editing, small-molecule probes, and high-resolution, time-lapse imaging, we find that stabilization of wild-type p53 delays the onset of ferroptosis in response to cystine deprivation...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346532/what-color-should-glacier-algae-be
#3
Roman J Dial, Gerard Q Ganey, S McKenzie Skiles
Red-colored secondary pigments in glacier algae play an adaptive role in melting snow and ice. We advance this hypothesis using a model of color-based absorption of irradiance, an experiment with colored particles in snow, and the natural history of glacier algae. Carotenoids and phenols-astaxanthin in snow-algae and purpurogallin in ice-algae-shield photosynthetic apparatus by absorbing over-abundant visible wavelengths, then dissipating the excess radiant energy as heat. This heat melts proximal ice crystals, providing liquid-water in a 0°C environment and freeing-up nutrients bound in frozen water...
January 15, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29345608/food-choices-to-meet-nutrient-recommendations-for-the-adult-brazilian-population-based-on-the-linear-programming-approach
#4
Quenia Dos Santos, Rosely Sichieri, Nicole Darmon, Matthieu Maillot, Eliseu Verly-Junior
OBJECTIVE: To identify optimal food choices that meet nutritional recommendations to reduce prevalence of inadequate nutrient intakes. DESIGN: Linear programming was used to obtain an optimized diet with sixty-eight foods with the least difference from the observed population mean dietary intake while meeting a set of nutritional goals that included reduction in the prevalence of inadequate nutrient intakes to ≤20 %. SETTING: Brazil. SUBJECTS: Participants (men and women, n 25 324) aged 20 years or more from the first National Dietary Survey (NDS) 2008-2009...
January 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29345569/a-complex-scenario-and-underestimated-challenge-the-tumor-microenvironment-er-stress-and-cancer-treatment
#5
Oleg I Chen, Yaroslav P Bobak, Oleh V Stasyk, Leoni A Kunz-Schughart
The paradoxical role of ER stress in malignant diseases is only just being unraveled and remains incompletely understood. A particular challenge is the complex interplay between spaciotemporal and locoregional microenvironmental constraints in solid tumors and stress responses upon treatment; thus, the potential for new combinatorial therapeutic options to foster the coincidence of ER stress-related deadly events is likely to be underestimated. Without claiming this review to be complete, we present a comprehensive overview of the signaling mechanisms associated with the unfolded protein response (UPR) and the molecular link to cell survival and death mechanisms...
January 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29345056/for-when-bacterial-infections-persist-toll-like-receptor-inducible-direct-antimicrobial-pathways-in-macrophages
#6
REVIEW
Claudia J Stocks, Mark A Schembri, Matthew J Sweet, Ronan Kapetanovic
Macrophages are linchpins of innate immunity, responding to invading microorganisms by initiating coordinated inflammatory and antimicrobial programs. Immediate antimicrobial responses, such as NADPH-dependent reactive oxygen species (ROS), are triggered upon phagocytic receptor engagement. Macrophages also detect and respond to microbial products through pattern recognition receptors (PRRs), such as TLRs. TLR signaling influences multiple biological processes including antigen presentation, cell survival, inflammation, and direct antimicrobial responses...
January 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29344695/succession-of-microbial-communities-and-changes-of-incremental-oil-in-a-post-polymer-flooded-reservoir-with-nutrient-stimulation
#7
Peike Gao, Guoqiang Li, Jianjun Le, Xiaobo Liu, Fang Liu, Ting Ma
Further exploitation of the residual oil underground in post-polymer flooded reservoirs is attractive and challengeable. In this study, indigenous microbial enhanced oil recovery (IMEOR) in a post-polymer flooded reservoir was performed. The succession of microbial communities was revealed by high-throughput sequencing of 16S rRNA genes and changes of incremental oil were analyzed. The results indicated that the abundances of reservoir microorganisms significantly increased, with alpha diversities decreased in the IMEOR process...
January 17, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29344415/rhizoma-coptidis-and-berberine-as-a-natural-drug-to-combat-aging-and-aging-related-diseases-via-anti-oxidation-and-ampk-activation
#8
REVIEW
Zhifang Xu, Wei Feng, Qian Shen, Nannan Yu, Kun Yu, Shenjun Wang, Zhigang Chen, Seiji Shioda, Yi Guo
Aging is the greatest risk factor for human diseases, as it results in cellular growth arrest, impaired tissue function and metabolism, ultimately impacting life span. Two different mechanisms are thought to be primary causes of aging. One is cumulative DNA damage induced by a perpetuating cycle of oxidative stress; the other is nutrient-sensing adenosine monophosphate-activated protein kinase (AMPK) and rapamycin (mTOR)/ ribosomal protein S6 (rpS6) pathways. As the main bioactive component of natural Chinese medicine rhizoma coptidis (RC), berberine has recently been reported to expand life span in Drosophila melanogaster, and attenuate premature cellular senescence...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344041/impact-of-nutrition-education-in-improving-dietary-pattern-during-pregnancy-based-on-pender-s-health-promotion-model-a-randomized-clinical-trial
#9
Masoomeh Goodarzi-Khoigani, Mohammad Hossein Baghiani Moghadam, Azadeh Nadjarzadeh, Farahnaz Mardanian, Hossein Fallahzadeh, SeyedSaeed Mazloomy-Mahmoodabad
Background: Different types of nutrients in adequate amounts are required to meet the increased demands of the mother and the developing fetus. Therefore, we examined the impact of nutrition education on the number of food servings per day. Materials and Methods: Pregnant mothers were recruited to a prospective, randomized clinical trial from May to September, 2016. At 6-10 weeks of gestation, the participants were randomly divided into the intervention (n = 96) or the control group (n = 96), and were followed-up until the end of pregnancy...
January 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29343844/determinants-of-population-responses-to-environmental-fluctuations
#10
Jose M G Vilar, J Miguel Rubi
Environmental fluctuations, such as changing conditions and variable nutrient availability, are an unavoidable component of the dynamics of virtually all populations. They affect populations in ways that are often difficult to predict and sometimes lead to paradoxical outcomes. Here, we present a general analytical approach to examine how populations respond to fluctuations. We show that there exist general explicit conditions that determine to what extent fluctuations propagate to the variability of the responses and how they change the behavior of the system, including whether they promote proliferation or death and whether they facilitate coexistence or exclusion of competing species...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343796/integrated-climate-chemical-indicators-of-diffuse-pollution-from-land-to-water
#11
Per-Erik Mellander, Phil Jordan, Marianne Bechmann, Ophélie Fovet, Mairead M Shore, Noeleen T McDonald, Chantal Gascuel-Odoux
Management of agricultural diffuse pollution to water remains a challenge and is influenced by the complex interactions of rainfall-runoff pathways, soil and nutrient management, agricultural landscape heterogeneity and biogeochemical cycling in receiving water bodies. Amplified cycles of weather can also influence nutrient loss to water although they are less considered in policy reviews. Here, we present the development of climate-chemical indicators of diffuse pollution in highly monitored catchments in Western Europe...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343498/the-gpr120-agonist-tug-891-promotes-metabolic-health-by-stimulating-mitochondrial-respiration-in-brown-fat
#12
Maaike Schilperoort, Andrea D van Dam, Geerte Hoeke, Irina G Shabalina, Anthony Okolo, Aylin C Hanyaloglu, Lea H Dib, Isabel M Mol, Natarin Caengprasath, Yi-Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coskun, Bharat Shimpukade, Trond Ulven, Sander Kooijman, Patrick Cn Rensen, Mark Christian
Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related disorders. Recent studies demonstrated a role for G protein-coupled receptor 120 (GPR120) in BAT thermogenesis. Here, we investigated the therapeutic potential of GPR120 agonism and addressed GPR120-mediated signaling in BAT We found that activation of GPR120 by the selective agonist TUG-891 acutely increases fat oxidation and reduces body weight and fat mass in C57Bl/6J mice...
January 17, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29342876/improvement-of-verticillium-wilt-resistance-by-applying-arbuscular-mycorrhizal-fungi-to-a-cotton-variety-with-high-symbiotic-efficiency-under-field-conditions
#13
Qiang Zhang, Xinpeng Gao, Yanyun Ren, Xinhua Ding, Jiajia Qiu, Ning Li, Fanchang Zeng, Zhaohui Chu
Arbuscular mycorrhizal fungi (AMF) play an important role in nutrient cycling processes and plant stress resistance. To evaluate the effect of Rhizophagus irregularis CD1 on plant growth promotion (PGP) and Verticillium wilt disease, the symbiotic efficiency of AMF (SEA) was first investigated over a range of 3% to 94% in 17 cotton varieties. The high-SEA subgroup had significant PGP effects in a greenhouse. From these results, the highest-SEA variety of Lumian 1 was selected for a two-year field assay. Consistent with the performance from the greenhouse, the AMF-mediated PGP of Lumian 1 also produced significant results, including an increased plant height, stem diameter, number of petioles, and phosphorus content...
January 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29342424/corrigendum-to-effect-of-biochar-on-the-presence-of-nutrients-and-ryegrass-growth-in-the-soil-from-an-abandoned-indigenous-coking-site-the-potential-role-of-biochar-in-the-revegetation-of-contaminated-site-sci-total-environ-601-602-2017-469-477
#14
EDITORIAL
Guixiang Zhang, Yuen Zhu, Xiaofang Guo, Zhiwang Han, Qiusheng He, Fengsong Zhang
No abstract text is available yet for this article.
January 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29342407/vitamin-d-and-iron-deficiencies-in-children-and-adolescents-with-cerebral-palsy
#15
C Le Roy, S Barja, C Sepúlveda, M L Guzmán, M Olivarez, M J Figueroa, M Alvarez
INTRODUCTION: Children and adolescents with cerebral palsy (CP) are at a greater risk of malnutrition and micronutrient deficiencies. Two deficiencies that we can study and treat are vitaminD (VD) and iron deficiencies; however, no studies have described these deficiencies in Chile. OBJECTIVE: To describe the status of VD and iron in patients with CP and evaluate the relationship with certain factors associated with deficiencies of these micronutrients. PATIENTS AND METHOD: We performed a descriptive, cross-sectional study including 69 patients aged between 2 and 21years, from two public hospitals...
January 13, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29342148/a-strong-summer-phytoplankton-bloom-southeast-of-vietnam-in-2007-a-transitional-year-from-el-ni%C3%A3-o-to-la-ni%C3%A3-a
#16
Hui Zhao, Jian Zhao, Xingli Sun, Fajin Chen, Guoqi Han
Summer upwelling occurs frequently off the southeast Vietnam coast in the western South China Sea (SCS), where summer phytoplankton blooms generally appear during June-August. In this study, we investigate inter-annual variation of Ekman pumping and offshore transport, and its modulation on summer blooms southeast of Vietnam. The results indicate that there are low intensities of summer blooms in El Niño years, under higher sea surface temperatures (SST) and weaker winds. However, a different pattern of monthly chlorophyll a (Chl-a) blooms occurred in summer of 2007, a transitional stage from El Niño to La Niña, with weak (strong) wind and high (low) SST before (after) early July...
2018: PloS One
https://www.readbyqxmd.com/read/29341931/bioinspired-capsules-based-on-nanocellulose-xyloglucan-and-pectin-the-influence-of-capsule-wall-composition-on-permeability-properties
#17
T Paulraj, A V Riazanova, A J Svagan
Materials based on renewable biopolymers, selective permeability and stimuli-responsive release/loading properties play an important role in biomedical applications. Here, in order to mimic the plant primary cell-wall, microcapsules have been fabricated using cell wall polysaccharides, namely pectin, xyloglucan and cellulose nanofibers. For the first time, a large amount of xyloglucan was successfully included in such capsules. These capsules demonstrated stimuli-responsive (ON/OFF) permeability and biocompatibility...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341449/digging-deeper-a-holistic-perspective-of-factors-affecting-soil-organic-carbon-sequestration-in-agroecosystems
#18
Rattan Lal
The global magnitude (Pg) of soil organic carbon (SOC) is 677 to 0.3-m, 993 to 0.5-m, and 1505 to 1-m depth. Thus, ~55% of SOC to 1-m lies below 0.3-m depth. Soils of agroecosystems are depleted of their SOC stock and have a low use efficiency of inputs of agronomic yield. This review is a collation and synthesis of articles published in peer-reviewed journals. The rates of SOC sequestration are scaled up to the global level by linear extrapolation. Soil C sink capacity depends on depth, clay content and mineralogy, plant available water holding capacity, nutrient reserves, landscape position, and the antecedent SOC stock...
January 17, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29341143/loss-of-alkaline-ceramidase-inhibits-autophagy-in-arabidopsis-and-plays-an-important-role-during-environmental-stress-response
#19
Ping Zheng, Jian-Xin Wu, Sunil Kumar Sahu, Hong-Yun Zeng, Li-Qun Huang, Zhe Liu, Shi Xiao, Nan Yao
Sphingolipids, a class of bioactive lipids found in cell membranes, can modulate the biophysical properties of the membranes and play a critical role in signal transduction. Sphingolipids are involved in autophagy in humans and yeast, but their role in autophagy in plants is not well understood. In this study, we reported that the AtACER, an alkaline ceramidase that hydrolyzes ceramide to LCB, functions in autophagy process in Arabidopsis. Our empirical data showed that the loss of AtACER inhibited autophagy, while its overexpression promoted autophagy under nutrient, salinity, and oxidative stresses...
January 17, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29340860/trace-element-phytoextraction-from-contaminated-soil-a-case-study-under-mediterranean-climate
#20
Werther Guidi Nissim, Emily Palm, Stefano Mancuso, Elisa Azzarello
The current field study aims to assess the suitability of four different plant species (i.e. poplar, willow, hemp and alfalfa) to be used for trace element (TE) (i.e. Cd, Cu, Ni, Pb and Zn) phytoextraction under hot-arid Mediterranean climate conditions. Plants were grown for two consecutive years on a moderate TE contaminated soil, supplied with water and mineral nutrients. The growth and physiological parameters were assessed throughout the trial to compare the response of plants to the environmental pollution, and TE uptake rates were measured for aboveground plant tissues...
January 16, 2018: Environmental Science and Pollution Research International
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