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Evidence Based Medicine

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https://www.readbyqxmd.com/read/29684682/identification-and-validation-nucleolin-as-a-target-of-curcumol-in-nasopharyngeal-carcinoma-cells
#1
Juan Wang, Jiacai Wu, Xumei Li, Haowei Liu, Jianli Qin, Zhun Bai, Bixia Chi, Chen Xu
Identification of the specific protein target(s) of a drug is a critical step in unraveling its mechanisms of action (MOA) in many natural products. Curcumol, isolated from well known Chinese medicinal plant Curcuma zedoary, has been shown to possess multiple biological activities. It can inhibit nasopharyngeal carcinoma (NPC) proliferation and induce apoptosis, but its target protein(s) in NPC cells remains unclear. In this study, we employed a mass spectrometry-based chemical proteomics approach reveal the possible protein targets of curcumol in NPC cells...
April 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29683939/-evidence-based-medicine-current-evidence-in-the-diagnosis-and-management-of-carpal-tunnel-syndrome
#2
Leonidas Pavlidis, Georgia Alexandra Spyropoulou, Elias Athanasopoulos, Efterpi Demiri
No abstract text is available yet for this article.
March 31, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29683555/clinical-obesity-services-in-public-hospitals-in-australia-a-position-statement-based-on-expert-consensus
#3
E Atlantis, N Kormas, K Samaras, P Fahey, P Sumithran, S Glastras, G Wittert, K Fusco, R Bishay, T Markovic, L Ding, K Williams, I Caterson, V Chikani, P Dugdale, J Dixon
We aimed to describe the current state of specialist obesity services for adults with clinically severe obesity in public hospitals in Australia, and to analyse the gap in resources based on expert consensus. We conducted two surveys to collect information about current and required specialist obesity services and resources using open-ended questionnaires. Organizational level data were sought from clinician expert representatives of specialist obesity services across Australia in 2017. Fifteen of 16 representatives of current services in New South Wales (n = 8), Queensland (n = 1), Victoria (n = 2), South Australia (n = 3), and the Australian Capital Territory (n = 1) provided data...
April 23, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29683106/towards-evidence-based-medicine-for-paediatricians
#4
Bob Phillips
No abstract text is available yet for this article.
April 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29683053/multidisciplinary-prerounding-meeting-as-a-continuous-quality-improvement-tool-leveraging-to-reduce-continuous-benzodiazepine-use-at-an-academic-medical-center
#5
Alexander H Flannery, Melissa L Thompson Bastin, Ashley Montgomery-Yates, Corrine Hook, Evan Cassity, Phillip M Eaton, Peter E Morris
BACKGROUND: Evidence-based medicine often has many barriers to overcome prior to implementation in practice, hence the importance of continuous quality improvement. We report on a brief (≤10 minutes) multidisciplinary meeting prior to rounds to establish a dashboard for continuous quality improvement and studied the success of this meeting on a particular area of focus: continuous infusion benzodiazepine minimization. METHODS: This was a prospective observational study of patients admitted to the medical intensive care unit (MICU) of a large academic medical center over a 4-month period...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29682706/-risk-factors-of-anastomotic-leakage-in-the-procedures-of-trans-abdominal-and-transanal-total-mesorectal-excision-for-rectal-cancer
#6
Hongwei Yao, Zhongtao Zhang
Anastomotic leakage is one of the most serious complications following traditional trans-abdominal total mesorectal excision of rectal cancer. Anastomotic leakage not only affects the postoperative recovery of patients, but also affects their long-term survival. Transanal total mesorectal excision(taTME) is a new surgical procedure developed in recent years. Its anastomosis is different from traditional trans-abdominal total mesorectal excision surgery. The risk of anastomotic leakage and related risk factors are also different...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29681969/standardization-of-the-manufacturing-process-of-bee-venom-pharmacopuncture-containing-melittin-as-the-active-ingredient
#7
Yoonmi Lee, Sung-Geun Kim, In-Su Kim, Hwa-Dong Lee
Background: Pharmacopuncture is a unique treatment in oriental medicine that combines chemical stimulation with conventional acupuncture. However, there are no standardized methods for preparing the herbal medicines used in pharmacopuncture, and it is not clear whether the active ingredients are safe and stable. Several studies have investigated nonstandardized preparation processes, but few investigations have addressed safety and preparation methods. Pharmacopuncture may provide an alternative treatment for incurable diseases...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681620/recontacting-or-not-recontacting-a-survey-of-current-practices-in-clinical-genetics-centres-in-europe
#8
Fabio Sirchia, Daniele Carrieri, Sandi Dheensa, Caroline Benjamin, Hülya Kayserili, Christophe Cordier, Carla G van El, Peter D Turnpenny, Bela Melegh, Álvaro Mendes, Tanya F Halbersma-Konings, Irene M van Langen, Anneke M Lucassen, Angus J Clarke, Francesca Forzano, Susan E Kelly
Advances in genomic medicine are improving diagnosis and treatment of some health conditions, and the question of whether former patients should be recontacted is therefore timely. The issue of recontacting is becoming more important with increased integration of genomics in 'mainstream' medicine. Empirical evidence is needed to advance the discussion over whether and how recontacting should be implemented. We administered a web-based survey to genetic services in European countries to collect information about existing infrastructures and practices relevant to recontacting patients...
April 23, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29681480/outcome-of-endodontic-surgery-a-meta-analysis-of-the-literature-part-3-comparison-of-endodontic-microsurgical-techniques-with-2-different-root-end-filling-materials
#9
REVIEW
Meetu R Kohli, Homayon Berenji, Frank C Setzer, Su-Min Lee, Bekir Karabucak
INTRODUCTION: The aim of the present study was to investigate the influence of root-end preparation and filling material on endodontic surgery outcome. A systematic review and meta-analysis was conducted to determine the outcome of resin-based endodontic surgery (RES, the use of high-magnification preparation of a shallow and concave root-end cavity and bonded resin-based root-end filling material) versus endodontic microsurgery (EMS, the use of high-magnification ultrasonic root-end preparation and root-end filling with SuperEBA [Keystone Industries, Gibbstown, NJ], IRM [Dentsply Sirona, York, PA], mineral trioxide aggregate [MTA], or other calcium silicate cements)...
April 19, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29681324/expectancy-modulation-of-opioid-neurotransmission
#10
Marta Pecina, Jon-Kar Zubieta
Expectancies are powerful modulators of cognitive and emotional experiences, as well as the neurobiological responses linked to these processes. In medicine, placebo effects are a clear example of how expectancies activate opioid neurotransmission in a treatment context, leading to the experience of analgesia and the improvement of emotional states, among other symptoms. Molecular neuroimaging techniques using positron emission tomography (PET) and the selective μ-opioid receptor tracer [11 C]carfentanil have significantly contributed to our understanding of the neurobiological systems involved in the formation of placebo effects...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/29680814/spect-v-q-for-the-diagnosis-of-pulmonary-embolism-protocol-for-a-systematic-review-and-meta-analysis-of-diagnostic-accuracy-and-clinical-outcome
#11
Pierre-Yves Le Roux, Philippe Robin, Cécile Tromeur, Alexandra Davis, Helia Robert-Ebadi, Marc Carrier, Francis Couturaud, Grégoire Le Gal, Pierre-Yves Salaun
INTRODUCTION: Single photon emission computed tomography ventilation/perfusion (SPECT V/Q) imaging has many proponents within the nuclear medicine community and has already largely replaced planar V/Q scintigraphy in daily practice for the diagnosis of pulmonary embolism (PE). However, the test is still described in clinical guidelines as an experimental test because of insufficient evidence. METHODS AND ANALYSIS: We will conduct a systematic review and a meta-analysis of diagnostic accuracy and management outcome studies involving patients evaluated with V/Q SPECT for suspected acute PE...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680141/-beneficence-and-nonmaleficence-in-care
#12
Isabelle Pipien
Is a medical decision rationally founded on the application of statistically efficient evidence-based medicine procedures fair and right for any given patient? Medical ethics invite us to consider the caregiving action through the prism of guidelines based on autonomy, beneficence/nonmaleficence and justice.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29679100/g-spotplasty-a-new-surgical-plastic-intervention-the-preliminary-study
#13
Adam Ostrzenski
BACKGROUND: Ostrzenski's G-pot anatomical structure discovery has been verified by the anatomy, histology, MRI in vivo, and electrovaginography in vivo studies. The objectives of this scientific-clinical investigation were to develop a new surgical reconstructive intervention (G-spotplasty); to determine the ability of G-spotplasty surgical implementation; to observe for potential complications; and to gather initial information on whether G-spotplasty improves female sexual activity, sexual behaviors, and sexual concerns...
April 20, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29678966/an-evaluation-of-prescribing-trends-and-patterns-of-claims-within-the-preferred-drugs-initiative-in-ireland-2011-2016-an-interrupted-time-series-study
#14
Ronald McDowell, Kathleen Bennett, Frank Moriarty, Sarah Clarke, Michael Barry, Tom Fahey
OBJECTIVE: To examine the impact of the Preferred Drugs Initiative (PDI), an Irish health policy aimed at enhancing evidence-based cost-effective prescribing, on prescribing trends and the cost of prescription medicines across seven medication classes. DESIGN: Retrospective repeated cross-sectional study spanning the years 2011 - 2016. SETTING: Health Service Executive Primary Care Reimbursement Service pharmacy claims data for General Medical Services (GMS) patients, approximately 40% of the Irish population...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678910/serotype-diversity-and-antimicrobial-resistance-among-salmonella-enterica-isolated-from-patients-at-an-equine-referral-hospital
#15
I M Leon, S D Lawhon, K N Norman, D S Threadgill, N Ohta, J Vinasco, H M Scott
Although Salmonella enterica can produce life-threatening colitis in horses, certain serotypes are more commonly associated with clinical disease. Our aim was to evaluate the proportional morbidity attributed to different serotypes, as well as phenotypic and genotypic antimicrobial resistance (AMR) of Salmonella isolated from patients at an equine referral hospital in the southern United States. Two-hundred-fifty-five Salmonella isolates were obtained from clinical samples of patients admitted to the hospital between 2007 and 2015...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29678866/gaps-in-guidelines-for-the-management-of-diabetes-in-low-and-middle-income-versus-high-income-countries-a-systematic-review
#16
REVIEW
Mayowa O Owolabi, Joseph O Yaria, Meena Daivadanam, Akintomiwa I Makanjuola, Gary Parker, Brian Oldenburg, Rajesh Vedanthan, Shane Norris, Ayodele R Oguntoye, Morenike A Osundina, Omarys Herasme, Sulaiman Lakoh, Luqman O Ogunjimi, Sarah E Abraham, Paul Olowoyo, Carolyn Jenkins, Wuwei Feng, Hernán Bayona, Sailesh Mohan, Rohina Joshi, Ruth Webster, Andre P Kengne, Antigona Trofor, Lucia Maria Lotrean, Devarsetty Praveen, Jessica H Zafra-Tanaka, Maria Lazo-Porras, Kirsten Bobrow, Michaela A Riddell, Konstantinos Makrilakis, Yannis Manios, Bruce Ovbiagele
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on evidence from high-income countries (HIC), can be implemented to improve outcomes in low- and middle-income countries (LMIC) is a critical challenge. We carried out a systematic review to compare type 2 DM guidelines in individual LMIC versus HIC over the past decade to identify aspects that could be improved to facilitate implementation. RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online databases and websites of diabetes associations and ministries of health...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678669/using-big-data-in-oncology-to-prospectively-impact-clinical-patient-care-a-proof-of-concept-study
#17
Vérène Dougoud-Chauvin, Jae Jin Lee, Edgardo Santos, Vonetta L Williams, Nicolò M L Battisti, Kavita Ghia, Marina Sehovic, Cortlin Croft, Jongphil Kim, Lodovico Balducci, Julie A Kish, Martine Extermann
OBJECTIVE: Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clinical trials. This study prospectively assessed the real-time availability of clinical cases in the Health & Research Informatics Total Cancer Care™ (TCC) database matching community patients with cancer, and the impact of such a consultation on treatment...
April 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29678575/silencing-lncrna-loxl1-as1-attenuates-mesenchymal-characteristics-of-glioblastoma-via-nf-%C3%AE%C2%BAb-pathway
#18
Hongjin Wang, Li Li, Lin Yin
The mesenchymal (MES) subtype of glioblastoma (GBM) suggested worseprognosis and a more malignant phenotype in comparison with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided clinical intervention with an manner. Few LncRNA, however, have been discovered to take part in the shift between subtypes. Here, we used transcriptomic data and experimental evidences to demonstrate that silencing LncRNA LOXL1-AS1 was a new regulator of NF-κB signaling pathway through repressing RELB directly, resulting in increased marker genes of PN subtype and decreased those of MES...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678045/approach-towards-an-evidence-oriented-knowledge-and-data-acquisition-for-the-optimization-of-interdisciplinary-care-in-dentistry-and-general-medicine
#19
Max W Seitz, Christian Haux, Petra Knaup, Ingrid Schubert, Stefan Listl
Associations between dental and chronic-systemic diseases were observed frequently in medical research, however the findings of this research have so far found little relevance in everyday clinical treatment. Major problems are the assessment of evidence for correlations between such diseases and how to integrate current medical knowledge into the intersectoral care of dentists and general practitioners. On the example of dental and chronic-systemic diseases, the Dent@Prevent project develops an interdisciplinary decision support system (DSS), which provides the specialists with information relevant for the treatment of such cases...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676534/consensus-based-european-guidelines-for-treatment-of-atopic-eczema-atopic-dermatitis-in-adults-and-children-part-i
#20
A Wollenberg, S Barbarot, T Bieber, S Christen-Zaech, M Deleuran, A Fink-Wagner, U Gieler, G Girolomoni, S Lau, A Muraro, M Czarnecka-Operacz, T Schäfer, P Schmid-Grendelmeier, D Simon, Z Szalai, J C Szepietowski, A Taïeb, A Torrelo, T Werfel, J Ring
This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions...
May 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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