keyword
https://read.qxmd.com/read/38536850/moving-together-increasing-physical-activity-in-older-adults-with-an-intergenerational-technology-based-intervention-a-feasibility-study
#1
JOURNAL ARTICLE
Rachel L Knight, Aïna Chalabaev, Kelly A Mackintosh, Melitta A McNarry, Joanne Hudson
Robust evidence supports the role of physical activity and exercise in increasing longevity, decreasing morbidity and helping older adults maintain the highest quality of life attainable. However, the majority of older adults are not sufficiently physically active and interventions are needed to change their behaviors. Familial or intergenerational contact has been positively linked to health and well-being in older adults. Therefore, this study aimed to i) establish acceptability and test the functionality and useability of a novel technology-driven intergenerational intervention targeting physical activity and age stereotypes, and ii) identify any potential issues with recruitment and retention...
2024: PloS One
https://read.qxmd.com/read/38536840/association-of-spironolactone-use-with-risk-of-urinary-tract-cancer-in-the-general-population-a-matched-population-based-cohort-study
#2
JOURNAL ARTICLE
Liang-Cheng Chen, Hsuan-Ju Yang, Ben-Hui Yu, Moon-Sing Lee, Hon-Yi Lin, Wen-Yen Chiou, Dai-Wei Liu, Feng-Chun Hsu, Chia-Hui Chew, Shih-Kai Hung
PURPOSE: The correlation between spironolactone usage and cancer risk has sparked interest. The objective of this study is to examine the association between spironolactone use and the incidence of urinary tract cancer in the general population. METHODS: We conducted a matched population-based cohort study. The study population was obtained from the Taiwan National Health Insurance Research Database (TNHIRD) during the period from 2000 to 2016. The multivariate Cox proportional hazard model was performed to examine the impact of spironolactone use on the risk of urinary tract cancer...
2024: PloS One
https://read.qxmd.com/read/38536530/the-paradox-of-mri-for-breast-cancer-screening-high-risk-and-dense-breasts-available-evidence-and-current-practice
#3
REVIEW
Francesco Sardanelli, Veronica Magni, Gabriele Rossini, Fleur Kilburn-Toppin, Nuala A Healy, Fiona J Gilbert
In the mid-1990s, the identification of BRCA1/2 genes for breast cancer susceptibility led to testing breast MRI accuracy in screening women at increased risk. From 2000 onwards, ten intraindividual comparative studies showed the marked superiority of MRI: the sensitivity ranged 25-58% for mammography, 33-52% for ultrasound, 48-67% for mammography plus ultrasound, and 71-100% for MRI; specificity 93-100%, 91-98%, 89-98%, and 81-98%, respectively. Based on the available evidence, in 2006-2007, the UK National Institute for Clinical Excellence and the American Cancer Society recommended MRI screening of high-risk women, followed by other international guidelines...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536431/enhancing-safety-in-tumescent-liposuction-managing-sedation-related-respiratory-issues-and-serious-complications-under-deep-sedation-with-the-propofol-ketamine-protocol
#4
JOURNAL ARTICLE
Eun Ju Kim, Hyunju Kim, Younchan Park
BACKGROUND: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. METHODS: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536430/a-grading-system-guided-approach-to-the-severely-contracted-nose
#5
JOURNAL ARTICLE
Dae Won Hong, Ji Hye Oh, Jessica Wang, Tae Hyung Kim, Young Chul Kim, Jong Woo Choi
PURPOSE: Capsular contracture is a rare but serious complication of silicone implant-based augmentation rhinoplasty. When severe, the contracture can affect all layers of the nose, causing significant scarring and disfigurement. There is currently no standardized method of evaluating contracted noses and a paucity of literature on the treatment of severe contracture. Therefore, this study aimed to establish a comprehensive grading system and treatment approach for patients with nasal contracture secondary to silicone implant-based rhinoplasty...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536429/double-chin-concerns-after%C3%A2-en-bloc-mandibular-u-shaped%C3%A2-osteotomy-submental-cervical-soft-tissue-changes-and-anterior-belly-of-digastric-muscle-assessment
#6
JOURNAL ARTICLE
Yingying Yue, Xiaoshuang Guo, Chenzhi Lai, Xiaolei Jin
OBJECTIVE: To assess submental-cervical soft tissue changes after en bloc mandibular U-shaped osteotomy and examine alterations in the anterior belly of digastric muscle (ABDM). METHODS: A retrospective study analyzed 20 patients who underwent en bloc mandibular U-shaped osteotomy from 2018 to 2023. Preoperative (Tp) and long-term follow-up (Tf) CT data were collected for analysis, measuring mandibular volume, soft tissue thickness at menton (Mes) and cervicale (C), and ABDM parameters (length, cross-sectional area (CSA), volume, distance from centroid point to the mandibular margin)...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536428/aesthetic-surgery-fellowship-at-akademikliniken-stockholm-survey-among-graduates
#7
JOURNAL ARTICLE
Paolo Montemurro, Yannick F Diehm, Per Hedén, Sebastian Fischer, Johannes M Wagner
BACKGROUND: Aesthetic Surgery is one of the most competitive fields of plastic surgery. Although there is a certain demand for highly educated surgeons in this field, training in cosmetic procedures remains challenging. Akademikliniken Stockholm offers a highly appreciated fellowship program for aesthetic plastic surgeons and trained more than 200 surgeons from all over the world. OBJECTIVES: The aim of the present work was to provide insights into this fellowship program, analyze what graduates have learned and if this had implications on their further professional orientation...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536234/target-product-profile-for-a-machine-learning-automated-retinal-imaging-analysis-software-for-use-in-english-diabetic-eye-screening-protocol-for-a-mixed-methods-study
#8
JOURNAL ARTICLE
Trystan Macdonald, Jacqueline Dinnes, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, Jeffry Hogg, John Kevin Dunbar, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Carl Macrae, Russell Pearson, Daniel Bamford, Adnan Tufail, Xiaoxuan Liu, Alastair K Denniston
BACKGROUND: Diabetic eye screening (DES) represents a significant opportunity for the application of machine learning (ML) technologies, which may improve clinical and service outcomes. However, successful integration of ML into DES requires careful product development, evaluation, and implementation. Target product profiles (TPPs) summarize the requirements necessary for successful implementation so these can guide product development and evaluation. OBJECTIVE: This study aims to produce a TPP for an ML-automated retinal imaging analysis software (ML-ARIAS) system for use in DES in England...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536227/patient-education-and-decision-support-for-long-acting-injectable-hiv-antiretroviral-therapy-protocol-for-tool-development-and-pilot-testing-with-ryan-white-hiv-aids-program-medical-case-management-programs-in-new-york
#9
JOURNAL ARTICLE
Mary Kathryn Irvine, Rebecca Zimba, Tigran Avoundjian, Meghan Peterson, Connor Emmert, Sarah G Kulkarni, Morgan M Philbin, Elizabeth A Kelvin, Denis Nash
BACKGROUND: Long-acting injectable (LAI) HIV antiretroviral therapy (ART) presents a major opportunity to facilitate and sustain HIV viral suppression, thus improving health and survival among people living with HIV and reducing the risk of onward transmission. However, realizing the public health potential of LAI ART requires reaching patients who face barriers to daily oral ART adherence and thus can clinically benefit from alternative treatment modalities. Ryan White HIV/AIDS Program Part A medical case management (MCM) programs provide an array of services to address barriers to HIV care and treatment among economically and socially marginalized people living with HIV...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536191/-recommendations-for-the-diagnostic-and-therapy-of-behavioural-and-psychological-symptoms-of-dementia-bpsd
#10
JOURNAL ARTICLE
Egemen Savaskan, Dan Georgescu, Stefanie Becker, Brigitte Benkert, Andreas Blessing, Markus Bürge, Ansgar Felbecker, Martin Hatzinger, Ulrich Michael Hemmeter, Therese Hirsbrunner, Stefan Klöppel, Gabriela Latour Erlinger, Finn Jacob Lornsen, Theofanis Ngamsri, Jessica Peter, Mathias Schlögl, Marc Sollberger, Henk Verloo, Samuel Vögeli, Franziska Zúñiga
The «Recommendations for the Diagnosis and Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD)» were developed in parallel with the Swiss National Dementia Strategy 2014-2019 under the auspices of the Swiss Society for Geriatric Psychiatry and Psychotherapy (SGAP) and mark the beginning of a series of recommendations for geriatric psychiatric disorders. They depict the evidence-based state of knowledge about diagnostics and therapy, based on the clinical experience of the experts, and are designed for interprofessional and interdisciplinary use...
February 2024: Praxis
https://read.qxmd.com/read/38536190/-forms-of-interprofessional-cooperation-in-outpatient-health-care-a-cross-case-analysis-in-german-speaking-switzerland
#11
JOURNAL ARTICLE
Bettina Schwind, Sonja Merten, Eva Hollenstein, Kaspar Wyss, Jana Gerold
The quality of care for the chronically ill is to be improved through interprofessional cooperation (IPC). To date, evaluation projects on IPC have mostly focused on the inpatient sector. The aim was to use a multiple case study design to investigate forms of IPC in primary care and to identify facilitating and inhibiting factors. Factors that facilitated the implementation of IPC included having a responsible person employed to provide the service, supportive training, and the introduction of evidence-based interventions...
February 2024: Praxis
https://read.qxmd.com/read/38536007/acute-myocarditis-an-overview-of-pathogenesis-diagnosis-and-management
#12
JOURNAL ARTICLE
Marina Zafeiri, Kristopher Knott, Temi Lampejo
Acute myocarditis encompasses a diverse presentation of inflammatory cardiomyopathies with infectious and non-infectious triggers. The clinical presentation is heterogeneous, from subtle symptoms like mild chest pain to life-threatening fulminant heart failure requiring urgent advanced hemodynamic support. This review provides a comprehensive overview of the current state of knowledge regarding the pathogenesis, diagnostic approach, management strategies, and directions for future research in acute myocarditis...
March 27, 2024: Panminerva Medica
https://read.qxmd.com/read/38535749/variation-in-breastfeeding-initiation-and-duration-by-mode-of-childbirth-a-prospective-population-based-study
#13
JOURNAL ARTICLE
Lindsay M Mallick, Edmond D Shenassa
Introduction: Despite known benefits of breastfeeding, including prevention against infections for infants, in the presence of numerous barriers, less than half of infants in high-income countries breastfeed for 6 months. One potential barrier to breastfeeding is birth by cesarean section (C-Section), which can invoke long-term difficulties. However, our structured literature review found that existing empirical research does not fully elucidate this relationship due to differences in operationalization of C-section and breastfeeding, omission of important confounders, and failure to exclude those who did not initiate breastfeeding (or use time-to-event analyses)...
March 27, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38535679/biomimetic-scaffolds-a-novel-approach-to-three-dimensional-cell-culture-techniques-for-potential-implementation-in-tissue-engineering
#14
REVIEW
Tomasz Górnicki, Jakub Lambrinow, Afsaneh Golkar-Narenji, Krzysztof Data, Dominika Domagała, Julia Niebora, Maryam Farzaneh, Paul Mozdziak, Maciej Zabel, Paweł Antosik, Dorota Bukowska, Kornel Ratajczak, Marzenna Podhorska-Okołów, Piotr Dzięgiel, Bartosz Kempisty
Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible and can influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic scaffolds adds complexity to traditional cell cultivation methods. The most commonly used technique involves cultivating cells on a flat surface in a two-dimensional format due to its simplicity. A three-dimensional (3D) format can provide a microenvironment for surrounding cells. There are two main techniques for obtaining 3D structures based on the presence of scaffolding...
March 16, 2024: Nanomaterials
https://read.qxmd.com/read/38535515/school-medical-service-strategies-to-promote-psycho-physiological-well-being
#15
REVIEW
Francesco Tafuri, Francesca Latino
Schools represent the ideal setting for educating children about the acquisition of active lifestyles seen not only from a health point of view but also from psycho-pedagogical and social perspectives. Based on evidence from scientific literature, there is a need to include physical activity in school routines, especially in primary schools, where the habits learned by children stay with them in their later years and adulthood. With the support of the school medicine service, schools become a favorable context for planning health education sessions aimed at students, with particular reference to prevention...
March 19, 2024: Pediatric Reports
https://read.qxmd.com/read/38535499/modulation-of-the-mas-related-g-protein-coupled-receptor-x2-mrgprx2-by-xenobiotic-compounds-and-its-relevance-to-human-diseases
#16
REVIEW
Alicja Dziadowiec, Iwona Popiolek, Mateusz Kwitniewski, Grzegorz Porebski
Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis. In this paper, we review natural products and herbal medicines that may potentially interact with MRGPRX2...
March 13, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535034/lifestyle-medicine-for-the-prevention-and-treatment-of-pancreatitis-and-pancreatic-cancer
#17
REVIEW
Sruthi Kapliyil Subramanian, Bhaumik Brahmbhatt, Jennifer M Bailey-Lundberg, Nirav C Thosani, Pritesh Mutha
The incidence of pancreatitis and pancreatic cancer is on the upswing in the USA. These conditions often lead to higher healthcare costs due to the complex nature of diagnosis and the need for specialized medical interventions, surgical procedures, and prolonged medical management. The economic ramification encompasses direct healthcare expenses and indirect costs related to productivity losses, disability, and potential long-term care requirements. Increasing evidence underscores the importance of a healthy lifestyle in preventing and managing these conditions...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534986/papillary-thyroid-cancer-trends-in-the-wake-of-the-covid-19-pandemic-is-there-a-shift-toward-a-more-aggressive-entity
#18
JOURNAL ARTICLE
Iyad Hassan, Lina Hassan, Farooq Bacha, Mohammad Al Salameh, Omran Gatee, Wiam Hassan
BACKGROUND: Globally, the incidence of papillary thyroid cancer (PTC) has been increasing over the last few decades and it has become the second most common cancer in women in the UAE. There is some evidence to suggest that COVID-19 infection might be directly linked to the development of aggressive variants of PTC. The primary goal of this study was to compare the clinical and pathologic characteristics of thyroid cancer patients treated at the largest endocrine surgery center in Abu Dhabi before and after the COVID-19 pandemic outbreak...
March 20, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534965/safety-and-efficacy-of-convalescent-plasma-combined-with-other-pharmaceutical-agents-for-treatment-of-covid-19-in-hospitalized-patients-a-systematic-review-and-meta-analysis
#19
REVIEW
Massimo Franchini, Daniele Focosi, Mario Cruciani, Michael J Joyner, Liise-Anne Pirofski, Jonathon W Senefeld, Shmuel Shoham, David J Sullivan, Arturo Casadevall
Plasma collected from people recovered from COVID-19 (COVID-19 convalescent plasma, CCP) was the first antibody-based therapy employed to fight the pandemic. CCP was, however, often employed in combination with other drugs, such as the antiviral remdesivir and glucocorticoids. The possible effect of such interaction has never been investigated systematically. To assess the safety and efficacy of CCP combined with other agents for treatment of patients hospitalized for COVID-19, a systematic literature search using appropriate Medical Subject Heading (MeSH) terms was performed through PubMed, EMBASE, Cochrane central, medRxiv and bioRxiv...
February 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534936/barriers-and-unequal-access-to-timely-molecular-testing-results-addressing-the-inequities-in-cancer-care-delays-across-canada
#20
Stephanie Snow, Christine Brezden-Masley, Michael D Carter, Neesha Dhani, Cassandra Macaulay, Ravi Ramjeesingh, Michael J Raphael, Monika Slovinec D'Angelo, Filomena Servidio-Italiano
Genomic medicine is a powerful tool to improve diagnosis and outcomes for cancer patients by facilitating the delivery of the right drug at the right dose at the right time for the right patient. In 2023, a Canadian conference brought together leaders with expertise in different tumor types. The objective was to identify challenges and opportunities for change in terms of equitable and timely access to biomarker testing and reporting at the education, delivery, laboratory, patient, and health-system levels in Canada...
March 6, 2024: Current Oncology
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