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Evidence Based Medicine

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https://www.readbyqxmd.com/read/29049193/efficacy-and-safety-of-immunomodulatory-drugs-in-patients-with-anterior-uveitis-a-systematic-literature-review
#1
Alejandro Gómez-Gómez, Estíbaliz Loza, Maria Piedad Rosario, Gerard Espinosa, José M García Ruiz de Morales, Jose M Herreras, Santiago Muñoz-Fernández, Miguel Cordero-Coma
BACKGROUND: To assess the efficacy and safety of immunomodulatory drugs in patients with noninfectious anterior uveitis (AU). METHODS: Systematic review of studies were retrieved from Medline (1961 to March 2016), Embase (1961 to March 2016), and Cochrane Library (up to March 2016), and a complementary hand search was also performed. The selection criteria were as follows: (population) noninfectious AU patients, adults; (intervention) immunomodulatory drugs (any dose, regimen, route of administration, duration of treatment); (outcome) control of inflammation, steroid-sparing effect, AU flares, adverse events, and so on; (study design) systematic literature reviews, randomized controlled trials, and observational studies...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049114/alternatives-to-opioids-in-the-pharmacologic-management-of-chronic-pain-syndromes-a-narrative-review-of-randomized-controlled-and-blinded-clinical-trials
#2
Andrea L Nicol, Robert W Hurley, Honorio T Benzon
Chronic pain exerts a tremendous burden on individuals and societies. If one views chronic pain as a single disease entity, then it is the most common and costly medical condition. At present, medical professionals who treat patients in chronic pain are recommended to provide comprehensive and multidisciplinary treatments, which may include pharmacotherapy. Many providers use nonopioid medications to treat chronic pain; however, for some patients, opioid analgesics are the exclusive treatment of chronic pain...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049049/treatable-traits-of-chronic-airways-disease
#3
James Fingleton, Jo Hardy, Richard Beasley
PURPOSE OF REVIEW: To describe the rationale on which the treatable traits approach to the management of airways disease is based and the issues that need to be considered for its implementation in clinical practice. RECENT FINDINGS: In clinical practice, treatable traits can be classified according to both endotypes and phenotypes, broadly grouped within pulmonary, extrapulmonary, environmental and behavioural factors. Specific investigations and treatments are undertaken for each of the traits rather than a 'one size fits all' stepwise approach to pharmacological treatment which currently represents the core of asthma and chronic obstructive pulmonary disease (COPD) guidelines...
October 18, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29048980/the-2016-lifetime-immunization-schedule-approved-by-the-italian-scientific-societies-a-new-paradigm-to-promote-vaccination-at-all-ages
#4
Paolo Bonanni, Giampietro Chiamenti, Giorgio Conforti, Tommasa Maio, Anna Odone, Rocco Russo, Silvestro Scotti, Carlo Signorelli, Alberto Villani
Medical scientific societies have the core mission of producing, pooling and disseminating solid and updated scientific information. We report the successful experience of the partnership of four national Medical Scientific Societies active in Italy in producing scientific advice on vaccines and vaccination. In particular, i) the Italian Society of Hygiene, Preventive Medicine and Public Health; SitI, ii) the Italian Society of Paediatrics; SIP, ii) the Italian Federation of Family Paediatricians; FIMP, and iv) the Italian Federation of General Medicine FIMMG) have worked together since 2012 to produce shared evidence-based recommendations on vaccination schedules, namely the "Lifetime Immunization Schedule" which introduced for the first time in Italy a life-course approach to vaccination...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048340/helping-health-services-to-meet-the-needs-of-young-people-with-chronic-conditions-towards-a-developmental-model-for-transition
#5
REVIEW
Albert Farre, Janet E McDonagh
The transition to adult healthcare has been the subject of increased research and policy attention over many years. However, unmet needs of adolescent and young adults (AYAs) and their families continue to be documented, and universal implementation has yet to be realised. Therefore, it is pertinent to re-examine health transition in light of the principles of adolescent medicine from which it emerged, and consider this particular life transition in terms of a developmental milestone rather than a negotiation of structural boundaries between child and adult services...
October 19, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29048168/comment-on-the-ecstasy-and-agony-of-assay-interference-compounds
#6
Peter W Kenny
.A recent editorial (Aldrich et al, The Ecstasy and Agony of Assay Interference Compounds, J. Chem. Inf. MODEL: , 2017, 57, 387-390) is examined critically. When assessing assay hits from screening, it is important to draw a distinction between false positives, that have no effect on target function, and compounds that affect target function through an undesirable mechanism of action. Observation of frequent-hitter behavior for a compound should be regarded as circumstantial evidence, rather than definitive proof, that the compound has interfered with assay readouts or acted through an undesirable mechanism of action...
October 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29047408/the-efficacy-of-the-kampo-medicine-rikkunshito-for-chemotherapy-induced-anorexia-rich-trial-study-protocol-for-a-randomized-controlled-trial
#7
Takuya Inoue, Hironori Takagi, Yuki Owada, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Hiroshi Yokouchi, Kenya Kanazawa, Katsuya Ohbuchi, Takahisa Fukushima, Mitsuru Munakata, Hiroyuki Suzuki
BACKGROUND: Cisplatin is a key drug in lung cancer therapy. However, cisplatin is also well known to induce gastrointestinal disorders, such as chemotherapy-induced nausea and vomiting, anorexia, and weight loss. These symptoms sometimes affect patients' quality of life and make continuation of chemotherapy difficult. Anorexia is a cause of concern for patients with cancer because a persistent loss of appetite progresses to cancer cachexia. Although evidence-based management for chemotherapy has recently been established, there is room for improvement...
October 18, 2017: Trials
https://www.readbyqxmd.com/read/29047339/exploring-the-evidence-base-for-how-people-with-dementia-and-their-informal-carers-manage-their-medication-in-the-community-a-mixed-studies-review
#8
Lydia Aston, Andrea Hilton, Tiago Moutela, Rachel Shaw, Ian Maidment
BACKGROUND: Little is known about the general medicines management issues for people with dementia living in the community. This review has three aims: firstly to explore and evaluate the international literature on how people with dementia manage medication; assess understanding of medicines management from an informal carers perspective; and lastly to understand the role that healthcare professionals play in assisting this population with medicines management. METHODS: A mixed studies review was conducted...
October 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29046352/the-lignan-manassantin-is-a-potent-and-specific-inhibitor-of-mitochondrial-complex-i-and-bioenergetic-activity-in-mammals
#9
Yibao Ma, Hae-Ki Min, Unsong Oh, Adam M Hawkridge, Wei Wang, Ahmed A Mohsin, Qun Chen, Arun Sanyal, Edward J Lesnefsky, Xianjun Fang
Dineolignans manassantin A and B from the plant Saururus cernuus are used in traditional medicine to manage a wide range of ailments such as edema, jaundice, and gonorrhea. Cell-based studies have identified several molecular target candidates of manassantin including NF-kappaB, MAPK, STAT3 and hypoxia-inducible factor 1 alpha (HIF-1alpha). It is unclear whether or how these structurally diverse proteins or pathways mediate any of the medical benefits of manassantin in vivo. Moreover, it has been recently reported that manassantin causes developmental arrest in zebrafish by inhibiting the mitochondrial complex I, but it is unknown whether manassantin inhibits mitochondrial respiration in intact mammalian cells and live animals...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29046001/-different-symptoms-and-course-of-coronary-heart-disease-in%C3%A2-men%C3%A2-and-women
#10
Christopher Hohmann, Roman Pfister, Guido Michels
According to the federal statistical office, cardiovascular disorders are still the leading cause of death in Germany. Chronic ischemic heart disease and acute myocardial infarction are the most important subgroups. In addition to evidence-based and personalized medicine, in recent years gender medicine has been established as an independent research area. Gender differences are evident in the majority of prevalent diseases, including cardiovascular disorders. The following article provides an insight into the diagnostically and therapeutically specific aspects of coronary heart disease in men and women...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29045990/electronic-health-record-impacts-on-family-medicine-teachers-survey-of-third-year-medical-student-clerkship-preceptors-at-an-academic-medical-center
#11
Elizabeth Curry, Tamara K Oser, Sean M Oser
BACKGROUND AND OBJECTIVES: Electronic Health Record (EHR) use in clinical practice has accelerated in recent years. While several aspects of EHR use have been extensively studied, there is little data on EHR impacts on medical student educators, especially those involved in outpatient family medicine. This study evaluated perceived impacts of EHR use on clinician teachers of outpatient family medicine. METHODS: The study used a mixed methods survey of clinicians who teach third-year medical students during the required family and community medicine outpatient clerkship at a Mid-Atlantic medical school...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045715/towards-precision-medicine-in-anca-associated-vasculitis
#12
Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
ANCA-associated vasculitis (AAV) is characterized by inflammation and destruction of small and medium-sized vessels. Current management strategies for AAV have been validated in large groups of patients. However, recent insights indicate that distinct patient subsets may actually exist within AAV, thereby justifying the development of more personalized treatment strategies. In this review, we discuss current evidence for a better classification of AAV based on ANCA type. We describe how thus defined categories of AAV patients may differ in genetic background, clinical presentation, immune pathology, response to treatment and disease outcome...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045078/skin-tears-and-risk-factors-assessment-a-systematic-review-on-evidence-based-medicine
#13
Raffaele Serra, Nicola Ielapi, Andrea Barbetta, Stefano de Franciscis
Skin tears represent a common condition of traumatic wounds, which may be encountered in some categories of individuals at the extremes of age, such as infants and the elderly. Despite the high prevalence and cost of these lesions, there has been little investigation into the risk factors that lead to this condition. The aim of this review was to systematically evaluate the main risk factors involved in development of skin tears. We planned to include all the studies dealing with risk factors related to skin tears...
October 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29044473/induced-pluripotent-stem-cells-from-ovarian-tissue
#14
Sophia Salas, Nicholas Ng, Behzad Gerami-Naini, Raymond M Anchan
Yamanaka and colleagues revolutionized stem cell biology and regenerative medicine by observing that somatic cells can be reprogrammed into pluripotent stem cells. Evidence indicates that induced pluripotent stem (iPS) cells retain epigenetic memories that bias their spontaneous differentiation into the originating somatic cell type, therefore epigenetic memory may be exploited to improve tissue specific regeneration. We recently showed that iPS cells reprogrammed from ovarian granulosa cells using mouse and human tissue overwhelmingly differentiate homotypically into ovarian steroidogenic and primordial germ cells...
October 18, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/29043986/potential-of-big-data-analytics-in-the-french-in-vitro-diagnostics-market
#15
Nicolas Dubois, Nicolas Garnier, Christophe Meune
The new paradigm of the big data raises many expectations, particularly in the field of health. Curiously, even though medical biology laboratories generate a great amount of data, the opportunities offered by this new field are poorly documented. For better understanding the clinical context of chronical disease follow-up, for leveraging preventive and/or personalized medicine, the contribution of big data analytics seems very promising. It is within this framework that we have explored to use data of a Breton group of laboratories of medical biology to analyze the possible contributions of their exploitation in the improvement of the clinical practices and to anticipate the evolution of pathologies for the benefit of patients...
October 18, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29043949/arthroscopic-surgery-for-knee-osteoarthritis-impact-of-health-technology-assessment-in-germany
#16
Naomi Fujita-Rohwerder, Alric Rüther, Stefan Sauerland
OBJECTIVES: This study aims to describe how a negative reimbursement decision-based on the health technology assessment (HTA) report of a nondrug intervention-affects healthcare providers in Germany. METHODS: Knee arthroscopy was chosen as an example, because as of April 2016 this procedure is no longer reimbursed for osteoarthritis, but is still covered for other indications, including meniscal lesions. The exclusion followed an HTA report prepared by the Institute for Quality and Efficiency in Health Care (IQWiG)...
October 18, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29043944/courting-apocalypse-creating-a-zombie-themed-evidence-based-medicine-game
#17
Amy E Blevins, Elizabeth Kiscaden, Jason Bengtson
In 2015, two librarians at the Hardin Library for the Health Sciences at the University of Iowa turned their dreams into a reality and secured funding to build a zombie-themed evidence-based medicine game. The game features a "choose your own adventure" style that takes students through a scenario where a disease outbreak is taking place and a resident is asked to use evidence-based medicine skills to select a screening and diagnostic tool to use on potentially infected patients. Feedback on the game has been positive, and future plans include building additional modules on therapy, harm, and prognosis...
October 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/29042287/the-genus-lycium-as-food-and-medicine-a-botanical-ethnobotanical-and-historical-review
#18
REVIEW
Ruyu Yao, Michael Heinrich, Caroline S Weckerle
ETHNOPHARMACOLOGICAL RELEVANCE: Lycium is widely distributed in the arid to semi-arid environments of North and South America, Africa, and Eurasia. In recent years, Lycium barbarum and L. chinense have been advertised as "superfood" with healthy properties. Despite of its popularity, there is a lack of an integrated and critical appraisal of the existing evidence for the use of Lycium. AIM OF THE STUDY: There is a need to understand: 1) Which species were used and how the uses of Lycium developed spatially and over time, 2) how uses differ among regions with different culture backgrounds, and 3) how traditional and current therapeutic and preventive health claims correlate with pharmacological findings...
October 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29040732/evidence-based-pain-medicine-inconvenient-truths
#19
Daniel B Carr
No abstract text is available yet for this article.
October 12, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29039627/beliefs-endorsement-and-application-of-homeopathy-disclosed-a-survey-among-ambulatory-care-physicians
#20
Stefan Markun, Marc Maeder, Thomas Rosemann, Sima Djalali
BACKGROUND: Explanation models for the effectiveness of homeopathy are not supported by natural sciences and the aggregated evidence from clinical trials is unconvincing. From this standpoint, placebo effects seem the most obvious explanation for the therapeutic effects experienced in homeopathy. Still, many physicians continue to prescribe homeopathic treatments. OBJECTIVES: Whether physicians who prescribe homeopathic treatments aim to achieve placebo effects or actually believe in specific effects is poorly understood...
October 17, 2017: Swiss Medical Weekly
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