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https://www.readbyqxmd.com/read/28713741/reconstruction-of-drug-induced-cleft-palate-using-bone-marrow-mesenchymal-stem-cell-in-rodents
#1
Julie Christy Amalraj, Manasa Gangothri, Hari Babu
BACKGROUND: Triamcinolone acetonide (TAC) (Kenacort*) is a commonly used synthetic glucocorticoid in today's medical practice. The drug is also a potential agent in inducing cleft palates in rats. This drug has been used to induce cleft palate in the fetus of the pregnant rats to bring out a suitable animal model for human cleft lip and palate. The drug was given intraperitoneally to induce congenital cleft palate in pregnant mother rats. AIM: The aim of this study is to induce congenital cleft palate in pregnant Wister albino rats and reconstruct the defect with bone marrow mesenchymal stem cells (BMSCs) isolated from the same species along with PLGA (poly lactic co glycolic acid) scaffold...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713737/maxillary-distraction-osteogenesis-in-unilateral-cleft-lip-and-palate-patients-with-rigid-external-distraction-system
#2
Shadi Alkhouri, Peter D Waite, Matthew B Davis, Ejvis Lamani, Chung How Kau
AIM: Distraction osteogenesis (DO) is a treatment option for patients with maxillary hypoplasia secondary to cleft lip and palate (CLP). PURPOSE: The aim of this study is to present a technique for maxillary DO using Le Fort I osteotomy with rigid external distraction (RED) system. SUBJECTS AND METHODS: The patient presented in this paper was an Asian female with CLP aged 13 years and 6 months. She presented with severe midfacial deficiency with a Class III dental malocclusion with a negative overjet and concave facial profile...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28712851/irf6-rs2235375-single-nucleotide-polymorphism-is-associated-with-isolated-non-syndromic-cleft-palate-but-not-with-cleft-lip-with-or-without-palate-in-south-indian-population
#3
Venkatesh Babu Gurramkonda, Altaf Hussain Syed, Jyotsna Murthy, Bhaskar V K S Lakkakula
INTRODUCTION: Transcription factors are very diverse family of proteins involved in activating or repressing the transcription of a gene at a given time. Several studies using animal models demonstrated the role of transcription factor genes in craniofacial development. OBJECTIVE: We aimed to investigate the association of IRF6 intron-6 polymorphism in the non-syndromic cleft lip with or without Palate in a south Indian population. METHODS: 173 unrelated nonsyndromic cleft lip with or without Palate patients and 176 controls without clefts patients were genotyped for IRF6 rs2235375 variant by allele-specific amplification using the KASPar single nucleotide polymorphism genotyping system...
June 26, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28709577/insufficient-evidence-suggesting-an%C3%A2-association-between-maternal-tobacco-exposure-and-cleft-lip-and%C3%A2-palate
#4
Romina Brignardello-Petersen
No abstract text is available yet for this article.
June 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28708645/a-digital-assessment-of-the-maxillary-deformity-correction-in-infants-with-bilateral-cleft-lip-and-palate-using-computer-aided-nasoalveolar-molding
#5
Xin Gong, Jun Zhao, Jiawei Zheng, Quan Yu
OBJECTIVES: To evaluate the maxillary alveolar repositioning of the infants with bilateral cleft lip and palate (BCLP) undergoing computer-aided nasoalveolar molding (CAD-NAM). METHODS: A total of 19 BCLP infants undergoing CAD-NAM were recruited as the treatment group, and 21 nonpresurgically treated BCLP patients served as controls. The upper alveolar morphology was measured and evaluated. Changes in all variables between pre- and post-CAD-NAM were compared. RESULTS: By the end of CAD-NAM, significant difference was found in the P-A, P'-A', and L-ideal midline (P < 0...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28708467/gender-differences-in-surgical-treatment-of-patients-with-cleft-lip-and-palate
#6
Anna Paganini, Camilla Hörfelt, Hans Mark
Numerous gender-based differences in medical treatment have been recognized due to conscious or unconscious perceptions, i.e. gender bias. The aim of the present study was to investigate whether gender differences exist in the surgical treatment of patients with cleft lip and palate (CLP) anomalies. This study is a retrospective review of 235 consecutive patients with non-syndromic unilateral CLP or bilateral CLP born between 1966 and 1986. Each chart was reviewed, and 2178 surgical procedures were registered and categorized as primary surgery (primary lip, palatal and alveolar repair) or secondary surgery (aesthetic and functional revision)...
July 14, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28705814/head-and-neck-mri-findings-in-charge-syndrome
#7
M J Hoch, S H Patel, D Jethanamest, W Win, G M Fatterpekar, J T Roland, M Hagiwara
Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and/or development, Genital and/or urinary abnormalities, and Ear abnormalities and deafness (CHARGE) syndrome is a disorder with multiple congenital anomalies seen on imaging. A retrospective review of 10 patients with CHARGE syndrome who underwent MR imaging of the brain as part of a preoperative evaluation for cochlear implantation was conducted. Structural abnormalities of the entire MR imaging of the head were evaluated, including the auditory system, olfactory system, face, skull base, and central nervous system...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28699387/low-laser-therapy-a-strategy-to-promote-the-osteogenic-differentiation-of-deciduous-dental-pulp-stem-cells-from-cleft-lip-and-palate-patients
#8
Carla Cristina Gomes Pinheiro, Milena Correa de Pinho, Ana Cecília Corrêa Aranha, Eduardo Fregnani, Daniela Franco Bueno
Dental pulp stem cells (DPSC) can undergo several types of differentiation, including osteogenic differentiation. One osteogenesis-inducing factor that has been previously described is "in vitro" low-level laser irradiation of cells. Laser irradiation promotes the acceleration of bone matrix mineralization of the cell strain. However, no consensus exists regarding the dose and treatment time. We used DPSC strains from cleft lip and palate patients because new bone tissue engineering strategies have used DPSC in preclinical and clinical trials for the rehabilitation of alveolar bone clefts...
July 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28692808/modulating-wnt-signaling-rescues-palate-morphogenesis-in-pax9-mutant-mice
#9
C Li, Y Lan, R Krumlauf, R Jiang
Cleft palate is a common birth defect caused by disruption of palatogenesis during embryonic development. Although mutations disrupting components of the Wnt signaling pathway have been associated with cleft lip and palate in humans and mice, the mechanisms involving canonical Wnt signaling and its regulation in secondary palate development are not well understood. Here, we report that canonical Wnt signaling plays an important role in Pax9-mediated regulation of secondary palate development. We found that cleft palate pathogenesis in Pax9-deficient embryos is accompanied by significantly reduced expression of Axin2, an endogenous target of canonical Wnt signaling, in the developing palatal mesenchyme, particularly in the posterior regions of the palatal shelves...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28692505/presurgical-orthopedic-treatment-using-modified-nostril-retainers-in-patients-with-unilateral-cleft-lip-with-or-without-cleft-palate
#10
Serap Titiz, Aynur Aras
This study aimed to present a new technique for presurgical orthopedic treatment of patients with unilateral cleft lip with or without cleft palate (UCL±P) by means of modified nostril retainers manufactured using a special mold with soft acrylic or orthodontic acrylics material. Nasal molding with the modified nostril retainer is considerably effective and comfortable for the patient.
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28684841/are-people-with-an-orofacial-cleft-at-a-higher-risk-of-dental-caries-a-systematic-review-and-meta-analysis
#11
V Worth, R Perry, T Ireland, A K Wills, J Sandy, A Ness
Objective To establish whether children born with an orofacial cleft have a higher risk of dental caries than individuals without cleft.Design A systematic review and meta-analysisMethods The search strategy was based on the key words 'cleft lip palate' and 'oral hygiene caries decay'. Ten databases were searched from their inception to April 2016 to identify all relevant studies. All data were extracted by two independent reviewers. The primary outcome measure was caries measured by the decayed, missing, filled surfaces/teeth index (dmfs/dmft or DMFS/DMFT)...
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28684073/craniofacial-and-extracraniofacial-anomalies-in-craniofacial-macrosomia-a-multicenter-study-of-755-patients
#12
Cornelia J J M Caron, Britt I Pluijmers, Eppo B Wolvius, Caspar W N Looman, Neil Bulstrode, Robert D Evans, Peter Ayliffe, John B Mulliken, David Dunaway, Bonnie Padwa, Maarten J Koudstaal
PURPOSE: Craniofacial microsomia (CFM) is a congenital malformation of structures derived from the first and second pharyngeal arches leading to underdevelopment of the face. However, besides the craniofacial underdevelopment, extracraniofacial anomalies including cardiac, renal and skeletal malformation have been described. The aim of this study is to analyse a large population of patients with regard to demographics, typical phenotypes including craniofacial and extracraniofacial anomalies, and the correlations between the different variables of this condition...
June 8, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28680871/the-effect-of-happiness-training-based-on-fordyce-model-on-perceived-stress-in-the-mothers-of-children-with-cleft-lip-and-palate
#13
Zeinab Hemati, Samira Abbasi, Somayeh Paki, Davood Kiani
Introduction: A child afflicted with facial deformities such as cleft lip and palate usually affects their parents, because of difficulties in nutrition, speech, aesthetics and social connections, and also imposing a lot of stress on them. The aim of this study was to investigate the effects of a happiness program on the perceived stress in the mothers of children with cleft lip and palate. Methods: This study was a quasi-experimental study in which 64 mothers of children with cleft lip and palate were divided by simple random sampling into intervention and control groups (n=64)...
June 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28678140/the-americleft-project-plaster-dental-casts-versus-digital-images-for-goslon-yardstick-ratings-when-used-in-intercenter-comparisons
#14
Ross E Long, John Daskalogiannakis, Ana M Mercado, Ronald R Hathaway, Jennifer Fessler, Kathleen A Russell
The purpose of this investigation was to determine reliability and validity of GOSLON Yardstick ratings using plaster casts versus photo galleries of digital images in actual intercenter comparisons. The dental arch relationships of 112 patients with complete unilateral cleft lip and palate from 3 North American cleft/craniofacial centers were rated in 2 separate studies. In the first, plaster casts were used. For a later intercenter comparison, the same dental casts were scanned, digital bases added, and two-dimensional photographic galleries (6 views) were created for each set of casts...
July 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28676318/postoperative-alar-base-symmetry-in-complete-unilateral-cleft-lip-and-palate-a-prospective-study
#15
Suresh Vyloppilli, K S Krishnakumar, Shermil Sayd, Sameer Latheef, Saju V Narayanan, Ajit Pati
In the evolution of cleft lip repair, there have been continuous attempts to minimize local trauma and to improve lip and nasal appearances. In order to obtain an aesthetically balanced development of midface, the primary surgical correction of the nasolabial area is of paramount importance. In this study, the importance of a back-cut extending cephalically above the inferior turbinate at the mucocutaneous junction which elevates the nostril floor on the cleft side for the purpose of achieving symmetry of the alar bases are analyzed by pre and postoperative photographic anthropometry...
June 9, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28675808/delayed-primary-palatal-closure-in-resource-poor-countries-speech-results-in-ugandan-older-children-and-young-adults-with-cleft-lip-and-palate
#16
Laura Bruneel, Anke Luyten, Kim Bettens, Evelien D'haeseleer, Cleo Dhondt, Andrew Hodges, George Galiwango, Hubert Vermeersch, Kristiane Van Lierde
AIMS: Unrepaired clefts still regularly occur in resource-poor countries as a result of limited health-care access. The purpose of the present study was to report resonance, airflow and articulation characteristics following delayed (≥8years) primary palatal closure. METHODS: Fifteen Ugandan participants with cleft (lip and) palate (CP±L) were included as well as 15 age- and gender-matched Ugandan subjects without clefts. Palatal closure was performed at a mean age of 15;10 years using the Sommerlad technique...
June 20, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28675016/-velopharyngeal-closure-pattern-and-speech-performance-among-submucous-cleft-palate-patients
#17
Yin Heng, Guo Chunli, Shi Bing, Li Yang, Li Jingtao
OBJECTIVE: To characterize the velopharyngeal closure patterns and speech performance among submucous cleft palate patients. METHODS: Patients with submucous cleft palate visiting the Department of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University between 2008 and 2016 were reviewed. Outcomes of subjective speech evaluation including velopharyngeal function, consonant articulation, and objective nasopharyngeal endoscopy including the mobility of soft palate, pharyngeal walls were retrospectively analyzed...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28675015/-association-between-non-syndromic-cleft-lip-with-or-without-cleft-palate-and-environmental-factors-in-ningxia
#18
Yu Lili, Ma Jian, Gao Junpeng, Zhai Kun, Zhu Jinfang, Huang Yongqing
OBJECTIVE: To investigate the association between non-syndromic cleft lip with or without cleft palate (NSCL/P) and environmental factors in Ningxia population. METHODS: This case-control study involved 453 NSCL/P patients and 452 normal newborns from Ningxia. A questionnaire focusing on various factors, including family history, pregnancy reaction, drug use during pregnancy, and infections, was used and responses were analyzed through Chi-square test and Logistic regression analysis with SPSS 16...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28673724/three-dimensional-printed-haptic-model-from-a-prenatal-surface-rendered-oropalatal-sonographic-view-a-new-tool-in-the-surgical-planning-of-cleft-lip-palate
#19
R Nicot, G Couly, J Ferri, J-M Levaillant
Three-dimensional (3D) ultrasound has significantly improved prenatal screening and perinatal care in the area of cleft lip/palate and other deformities, providing essential preoperative information to the surgical team. However, current 3D reconstruction modalities are limited primarily to display on a two-dimensional surface. In contrast, a 3D printed haptic model allows both the surgeon and the parents to develop a better understanding of the anatomy and the surgical procedure through the ability to interact directly with the printed model...
June 30, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28673207/a-cone-beam-computed-tomographic-evaluation-of-the-size-of-the-sella-turcica-in-patients-with-cleft-lip-and-palate
#20
Maryam Paknahad, Shoaleh Shahidi, Iman Khaleghi
OBJECTIVE: Changes in the size of the sella turcica are frequently related to pathologies and syndromes. The aim of this was to compare the sella turcica dimensions in patients with unilateral and bilateral cleft lip and palate and non-cleft subjects. METHODS: Cone beam computed tomography (CBCT) images of three groups consisted of 20 patients with unilateral cleft lip and palate; 20 patients with bilateral cleft lip and palate and a control group consisting of 20 non-cleft subjects were the research population in this pilot study...
July 4, 2017: Journal of Orthodontics
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