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Locally advanced prostate cancer

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https://www.readbyqxmd.com/read/27935821/stromal-hedgehog-signaling-maintains-smooth-muscle-and-hampers-micro-invasive-prostate-cancer
#1
Zhaohui Yang, Yu-Ching Peng, Anuradha Gopalan, Dong Gao, Yu Chen, Alexandra L Joyner
It is widely appreciated that reactive stroma or carcinoma-associated fibroblasts can influence epithelial tumor progression. In prostate cancer (PCa), the second most common male malignancy worldwide, the amount of reactive stroma is variable and has predictive value for tumor recurrence. By analyzing human PCa protein and RNA expression databases, we found smooth muscle cells (SMCs) are decreased in advanced tumors, whereas fibroblasts are maintained. In three mouse models of PCa, we found the composition of the stroma is distinct...
November 30, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27896639/seom-clinical-guideline-for-bone-metastases-from-solid-tumours-2016
#2
C Grávalos, C Rodríguez, A Sabino, M Á Seguí, J A Virizuela, A Carmona, J Cassinello, D Isla, C Jara, M Martín
Bone metastases are common in many advanced solid tumours, being breast, prostate, thyroid, lung, and renal cancer the most prevalent. Bone metastases can produce skeletal-related events (SREs), defined as pathological fracture, spinal cord compression, need of bone irradiation or need of bone surgery, and hypercalcaemia. Patients with bone metastases experience pain, functional impairment and have a negative impact on their quality of life. Several imaging techniques are available for diagnosis of this disease...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27882770/focal-therapy-as-primary-treatment-for-localized-prostate-cancer-definition-needs-and-future
#3
Adil Ouzzane, Nacim Betrouni, Massimo Valerio, Ardeshir Rastinehad, Pierre Colin, Guillaume Ploussard
Focal therapy (FT) may offer a promising treatment option in the field of low to intermediate risk localized prostate cancer. The aim of this concept is to combine minimal morbidity with cancer control as well as maintain the possibility of retreatment. Recent advances in MRI and targeted biopsy has improved the diagnostic pathway of prostate cancer and increased the interest in FT. However, before implementation of FT in routine clinical practice, several challenges are still to overcome including patient selection, treatment planning, post-therapy monitoring and definition of oncologic outcome surrogates...
November 24, 2016: Future Oncology
https://www.readbyqxmd.com/read/27879490/intense-uptake-in-amyloidosis-of-the-seminal-vesicles-on-68ga-psma-pet-mimicking-locally-advanced-prostate-cancer
#4
Maximilian Stephens, David Insoo Kim, Benjamin Shepherd, Sonja Gustafson, Paul Thomas
We report a case of benign senile seminal vesicle amyloidosis demonstrating intense Ga-prostate-specific membrane antigen (PSMA) uptake on PET/CT. A 68-year-old man underwent staging PSMA PET/CT and MRI for biopsy-proven prostate adenocarcinoma. There was an intense focus of Ga-PSMA uptake in the primary malignancy, as well as symmetrical intense uptake in the seminal vesicles bilaterally that was reported as multifocal disease with local invasion. Final histology after radical prostatectomy showed amyloidosis of the seminal vesicles without any evidence of prostate cancer...
November 22, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27866843/postoperative-radiotherapy-in-locally-advanced-prostate-cancer-a-question-of-who-and-when
#5
EDITORIAL
Christopher J D Wallis, Raj Satkunasivam, Robert K Nam
No abstract text is available yet for this article.
November 17, 2016: European Urology
https://www.readbyqxmd.com/read/27863486/costs-of-conservative-management-of-early-stage-prostate-cancer-compared-to-radical-prostatectomy-a-claims-data-analysis
#6
Alina Brandes, Florian Koerber, Larissa Schwarzkopf, Matthias Hunger, Wolf H Rogowski, Raphaela Waidelich
BACKGROUND: Due to widespread PSA testing incidence rates of localized prostate cancer increase but curative treatment is often not required. Overtreatment imposes a substantial economic burden on health care systems. We compared the direct medical costs of conservative management and radical therapy for the management of early-stage prostate cancer in routine care. METHODS: An observational study design is chosen based on claims data of a German statutory health insurance fund for the years 2008-2011...
November 18, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27856630/a-prospective-clinical-trial-of-18f-fluciclovine-pet-ct-neoadjuvant-therapy-response-in-invasive-ductal-and-invasive-lobular-breast-cancers
#7
Gary A Ulaner, Debra Goldman, Adriana Corben, Serge Lyashchenko, Mithat Gonen, Jason Lewis, Maura Dickler
: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid ((18)F-Fluciclovine) is a leucine analog radiotracer that depicts amino acid transport into cells. (18)F-Fluciclovine PET/CT visualizes malignancy including prostate cancer, invasive ductal breast cancer (IDC) and invasive lobular breast cancers (ILC). It has not been shown whether changes in (18)F-Fluciclovine avidity reflect changes in tumor burden resulting from treatment. This prospective clinical trial evaluates changes in (18)F-Fluciclovine-avidity compared to breast cancer therapy response, as determined by residual tumor burden on pathology...
November 17, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27845330/the-prognostic-role-of-tertiary-gleason-pattern-5-in-a-contemporary-grading-system-for-prostate-cancer
#8
W S Jang, C Y Yoon, M S Kim, D H Kang, Y J Kang, W S Jeong, M J Abalajon, W S Ham, Y D Choi
BACKGROUND: Recently, a new prostate cancer (PC) grading system has been introduced, where Gleason score (GS) 7 (3+4) and GS 7 (4+3) are categorized into two separate groups. However, GS 7 with tertiary Gleason pattern 5 (TGP5) was not incorporated in the new grading system. In the present study, we validated the prognostic role of TGP5 in the new classification. METHODS: We retrospectively reviewed the records of 1396 patients with localized GS 6-8 PC (pT2-3N0M0) who underwent radical prostatectomy at our institution between 2005 and 2014...
November 15, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27844130/-second-neoplasms-after-percutaneous-radiotherapy
#9
F Haidl, D Pfister, R Semrau, A Heidenreich
Radiation therapy represents an alternative treatment to radical prostatectomy in the management of clinically localized prostate cancer. Radiation-induced second neoplasms are defined by a latency period of at least 5 years, location within the field of radiation therapy, and a histology which differs from the primary tumor. Based on the data in the literature, there is a consistently increased risk of bladder cancer (HR: 1.67, 95% CI 1.55-1.80), rectal cancer (HR: 1.79, 95% CI 1.34-2.38), and colorectal cancer (HR: 1...
November 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27834929/prostate-specific-antigen-psa-as-predicting-marker-for-clinical-outcome-and-evaluation-of-early-toxicity-rate-after-high-dose-rate-brachytherapy-hdr-bt-in-combination-with-additional-external-beam-radiation-therapy-ebrt-for-high-risk-prostate-cancer
#10
Thorsten H Ecke, Hui-Juan Huang-Tiel, Klaus Golka, Silvia Selinski, Berit Christine Geis, Stephan Koswig, Katrin Bathe, Steffen Hallmann, Holger Gerullis
High-dose-rate brachytherapy (HDR-BT) with external beam radiation therapy (EBRT) is a common treatment option for locally advanced prostate cancer (PCa). Seventy-nine male patients (median age 71 years, range 50 to 79) with high-risk PCa underwent HDR-BT following EBRT between December 2009 and January 2016 with a median follow-up of 21 months. HDR-BT was administered in two treatment sessions (one week interval) with 9 Gy per fraction using a planning system and the Ir192 treatment unit GammaMed Plus iX. EBRT was performed with CT-based 3D-conformal treatment planning with a total dose administration of 50...
November 10, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27825433/advancement-of-mr-and-pet-mr-in-prostate-cancer
#11
REVIEW
Liza Lindenberg, Mark Ahlman, Baris Turkbey, Esther Mena, Peter Choyke
Multiparametric magnetic resonance (mpMRI) imaging has assumed a larger role in the diagnosis and management of prostate cancer. The current method of detecting prostate cancer relies on blind systematic biopsy, guided only by transrectal ultrasound that generally directs the needle biopsy to sextants of the prostate rather than specific lesions. MpMRI is playing an increasing role in the detection of primary cancer as it can visualize cancers and direct biopsies. However, even mpMRI is inherently nonspecific and numerous biopsies performed under MR guidance prove to be negative...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27824043/duration-of-the-anti-androgen-in-men-undergoing-6-months-of-an-lhrh-agonist-and-radiation-therapy-for-unfavorable-risk-prostate-cancer-and-the-risk-of-death
#12
N N Sanford, M-H Chen, M Loffredo, A Renshaw, P W Kantoff, A V D'Amico
BACKGROUND: Whether adding a first-generation anti-androgen (AA) to a luteinizing hormone-releasing hormone agonist in the radiotherapeutic management of unfavorable-risk prostate cancer (PC) reduces the risk of all-cause and PC-specific mortality (ACM and PCSM) among men within differing comorbidity subgroups is unknown. METHODS: Between 1995 and 2001, 206 men with unfavorable-risk PC were enrolled in a randomized trial comparing radiation with or without 6 months of androgen-deprivation therapy (ADT)...
November 8, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27809631/health-related-quality-of-life-among-prostate-cancer-patients-real-life-situation-at-the-beginning-of-treatment
#13
Susanne Bergius, Saku Torvinen, Timo Muhonen, Risto P Roine, Harri Sintonen, Kimmo Taari
OBJECTIVE: The aims of this study were to measure the real-life health-related quality of life (HRQoL) of newly diagnosed prostate cancer (PCa) patients, to compare it with that of the general male population and to explore factors affecting HRQoL. METHODS: All newly diagnosed PCa patients in the Helsinki University Hospital were asked to fill in 15D and EORTC QLQ-C30 questionnaires. Clinical background information was collected retrospectively from patient charts...
November 4, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27800606/promoting-cancer-control-in-africa-with-ubuntu-a-report-of-the-african-organization-for-research-and-training-in-africa-aortic-10-th-conference-2015-in-marrakech-morocco
#14
Kenneth O Simbiri, Christopher K Williams, Marcella Macaluso, Antonio Giordano
The objectives of the African Organization for Research and Training in Cancer (AORTIC), includes bringing products of decades of advances in cancer research to African populations through local and international collaboration. The consistent and huge growth in participation in the conferences and the diversity of the nations is a witness to the success of the organization thus far. The theme for the Tenth AORTIC International Conference on Cancer in Africa in Morocco in 2015 was "Road map to Cancer Control in Africa" and topics of discussion of paramount importance for low- and middle-income African countries included childhood cancers such as BL, cancers of the cervix, breast, and prostate; cancers associated with HIV-infection such as cervical, vulvar, and anal; as well as cancer care challenges associated with palliative care...
November 1, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27791459/tumor-infiltrating-t-lymphocytes-expressing-foxp3-ccr7-or-pd-1-predict-the-outcome-of-prostate-cancer-patients-subjected-to-salvage-radiotherapy-after-biochemical-relapse
#15
Valerio Nardone, Cirino Botta, Michele Caraglia, Elodia Claudia Martino, Maria Raffaella Ambrosio, Tommaso Carfagno, Paolo Tini, Leonardo Semeraro, Gabriella Misso, Anna Grimaldi, Mariarosaria Boccellino, Gaetano Facchini, Massimiliano Berretta, Gianluca Vischi, Bruno Jim Rocca, Aurora Barone, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Teresa Del Vecchio, Luigi Pirtoli, Pierpaolo Correale
Tumor immunologic microenvironment is strongly involved in tumor progression and the presence of tumor infiltrating lymphocytes (TIL) with different phenotypes has been demonstrated to be of prognostic relevance in different malignancies. We investigated whether TIL infiltration of tumor tissues could also predict the outcome of prostate cancer patients. To this end, we carried out a retrospective analysis correlating the outcome of locally advanced prostate cancer patients undergone salvage radiotherapy upon relapse after radical surgery with the infiltration by different TIL populations...
October 28, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27786455/nanoparticle-targeting-cd44-positive-cancer-cells-for-site-specific-drug-delivery-in-prostate-cancer-therapy
#16
Wen-Ying Huang, Jia-Ni Lin, Jer-Tsong Hsieh, Shen-Chieh Chou, Chih-Ho Lai, Eun-Jin Yun, U-Ging Lo, Rey-Chen Pong, Jui-Hsiang Lin, Yu-Hsin Lin
Prostate cancer is one of the leading causes of cancer death in adult men and is a multi-stage disease with therapeutic challenges of local recurrent advanced tumors and distant metastatic disease. CD44 is a multifunctional and multistructural cell surface glycoprotein that is involved in cell-cell interactions, cell proliferation, and cell migration. In the study, we produced negatively charged and biocompatible hyaluronic acid-based nanoparticles as a therapeutic system for targeting CD44-positive cancer cells...
October 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27779202/the-impact-of-local-treatment-of-the-primary-tumor-site-in-node-positive-and-metastatic-prostate-cancer-patients
#17
M Moschini, F Soria, A Briganti, S F Shariat
BACKGROUND: Surgical treatment of the primary tumor in patients with metastatic prostate cancer (mPCa) is gaining traction. We discuss the biological rational and the existing literature on this approach. METHODS: We reviewed the literature regarding surgical management of advanced and mPCa disease. RESULTS: Surgical removal of the primary tumor despite metastases is becoming a standard in an increasing number of malignancies. Basic science data support the use of surgical removal of the prostate in metastatic PCa...
October 25, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27767086/adenovirus-vector-carrying-reic-dkk-3-gene-neoadjuvant-intraprostatic-injection-for-high-risk-localized-prostate-cancer-undergoing-radical-prostatectomy
#18
H Kumon, Y Ariyoshi, K Sasaki, T Sadahira, M Araki, S Ebara, H Yanai, M Watanabe, Y Nasu
As the First-In-Human study of in situ gene therapy using an adenovirus vector carrying the human REIC (reduced expression in immortalized cell)/Dkk-3 gene (Ad-REIC), we conducted neoadjuvant intraprostatic injections in patients with high-risk localized prostate cancer undergoing radical prostatectomy (RP). Patients with recurrence probability of 35% or more within 5 years following RP, as calculated by Kattan's nomogram, were enrolled. Patients received two ultrasound-guided intratumoral injections at 2-week intervals, followed by RP 6 weeks after the second injection...
November 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27766313/estimating-the-impact-of-randomised-control-trial-results-on-clinical-practice-results-from-a-survey-and-modelling-study-of-androgen-deprivation-therapy-plus-radiotherapy-for-locally-advanced-prostate-cancer
#19
Annabelle South, Wendy R Parulekar, Matthew R Sydes, Bingshu E Chen, Mahesh K Parmar, Noel Clarke, Padraig Warde, Malcolm Mason
BACKGROUND: Recent trials have shown that the addition of external beam radiotherapy (EBRT) to androgen deprivation therapy (ADT) improves survival among men with locally advanced prostate cancer. OBJECTIVE: To examine the potential impact of these trials on changes in clinical practice and life-years saved. DESIGN SETTING AND PARTICIPANTS: A model was developed to examine the impact of changes in clinical practice in the UK. A survey of clinicians who treat men with prostate cancer in the UK and Canada was performed...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/27764046/68ga-dotatoc-and-68ga-psma-pet-ct-unmasked-a-case-of-prostate-cancer-with-neuroendocrine-differentiation
#20
Sirong Chen, Shing Kee Cheung, Ka-Nin Wong, Kwok Kee Wong, Chi-Lai Ho
A bedridden 90-year-old man with fever and elevated prostate-specific antigen (PSA) (49 ng/mL) was referred for differentiation between infection and tumor. F-FDG PET/CT was negative for infection, but Ga-PSMA PET/CT showed multiple lesions in prostate gland with infiltration to bladder wall and seminal vesicle, consistent with locally advanced prostate cancer. The lesion with the highest Ga-PSMA uptake was strongly avid for Ga-DOTATOC, suggesting neuroendocrine tumor differentiation. After hormonal therapy, PSA normalized, but chromogranin-A increased (from 251 to 398 ng/mL), inferring progression of neuroendocrine tumor differentiation...
December 2016: Clinical Nuclear Medicine
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