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Locally advanced prostate cancer

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https://www.readbyqxmd.com/read/28429951/-robotic-assisted-radical-prostatectomy-results-of-1500-surgeries
#1
J Kočárek, J Heráček, M Čermák, F Chmelík, M Matějková
INTRODUCTION: Prostate cancer is the most common malignant disease in men. The number of cases of prostate cancer has increased dramatically in recent 20 years. Radical prostatectomy is a surgical method for the first-line treatment of localised prostate cancer. We performed the first robotic-assisted radical prostatectomy on December 16th, 2005, achieved the boundary of 1000 robotic-assisted radical prostatectomies in 2012, and in 2015, we successfully completed the 1500th robotic-assisted operation on the prostate...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28426464/comparative-effectiveness-in-urology-a-state-of-the-art-review-utilizing-a-systematic-approach
#2
Jathin Bandari, Charles B Wessel, Bruce L Jacobs
PURPOSE OF REVIEW: Comparative effectiveness research plays a vital role in healthcare delivery by guiding evidence-based practices. We performed a state-of-the-art review of comparative effectiveness research in the urology literature for 2016, utilizing a systematic approach. Seven high-impact papers are reviewed in detail. RECENT FINDINGS: Across the breadth of urology, there were several important studies in comparative effectiveness research, of which we will highlight two randomized controlled trials and five observational trials: radiotherapy, prostatectomy, and active monitoring have equivalent mortality outcomes in patients with localized prostate cancer; the ideal modality of patient education is yet to be determined, and written education has minimal effect on patient perception of prostate specific antigen screening; robotic prostatectomy is associated with higher perioperative complication rates on a population basis; racial disparities exist in incontinence rates after treatment for localized prostate cancer, but not in irritative, bowel, or sexual function; androgen deprivation therapy is associated with higher fracture, peripheral artery disease, and cardiac-related complications than bilateral orchiectomy; robotic and open cystectomy offer comparable cancer-specific mortality and perioperative outcomes; and bonuses for low-cost hospitals can inadvertently reward low-quality hospitals...
April 19, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28424829/-mri-of-the-prostate
#3
D Nörenberg, O Solyanik, B Schlenker, G Magistro, B Ertl-Wagner, D A Clevert, C Stief, M F Reiser, M D'Anastasi
New clinical and technological advances in the field of magnetic resonance imaging (MRI) and targeted image-guided biopsy techniques have significantly improved the detection, localization and staging as well as active surveillance of prostate cancer in recent years. Multiparametric MRI (mpMRI) is currently the main imaging technique for the detection, characterization and diagnostics of metastasizing prostate cancer and is of high diagnostic importance for local staging within the framework of the detection of prostate cancer...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28417429/approach-to-androgen-deprivation-in-the-prostate-cancer-patient-with-pre-existing-cardiovascular-disease
#4
REVIEW
Alyssa K Greiman, Thomas E Keane
PURPOSE OF REVIEW: Androgen deprivation therapy (ADT) is a mainstay of treatment for advanced prostate cancer. Several studies have reported an association between ADT and an increase in cardiovascular events, especially in those receiving gonadotropin-releasing hormone (GnRH) agonists compared to GnRH antagonists. We review the body of literature reporting the association of ADT and cardiovascular morbidity, and discuss the proposed mechanism of cardiovascular disease due to ADT including metabolic changes that may promote atherosclerosis and local hormonal effects that may increase plaque rupture and thrombosis...
June 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28408152/cellular-determinants-and-microenvironmental-regulation-of-prostate-cancer-metastasis
#5
REVIEW
Kiera Rycaj, Hangwen Li, Jianjun Zhou, Xin Chen, Dean G Tang
Metastasis causes more than 90% of cancer-related deaths and most prostate cancer (PCa) patients also die from metastasis. The 'metastatic cascade' is a complex biological process that encompasses tumor cell dissociation (from the primary tumor), local invasion, intravasation, transport in circulation, extravasation, colonization, and overt growth in end organs. It has become clear that successful metastasis not only involves many tumor cell-intrinsic properties but also depends on productive interactions between cancer cells and the tumor microenvironment...
April 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28392836/androgen-deprivation-therapy-in-the-treatment-of-locally-advanced-nonmetastatic-prostate-cancer-practical-experience-and-a-review-of-the-clinical-trial-evidence
#6
REVIEW
Fouad Aoun, Ali Bourgi, Elias Ayoub, Elie El Rassy, Roland van Velthoven, Alexandre Peltier
Following new scientific insights, initial management for patients with high-risk nonmetastatic prostate cancer has changed considerably and rapidly over the last few years. Several clinical and pathologic variables should be taken into account when deciding the best treatment choice for those patients. These variables are summarized and discussed in detail. High radiation doses to the prostate are essential to achieve good local control in patients with high-risk nonmetastatic disease. Addition of androgen deprivation therapy (ADT) to radiation therapy has significantly improved overall survival and cancer-specific survival compared with radiation therapy alone without significantly increasing toxicity...
March 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28382154/analysis-of-origin-and-protein-protein-interaction-maps-suggests-distinct-oncogenic-role-of-nuclear-egfr-during-cancer-evolution
#7
Ainur Sharip, Diyora Abdukhakimova, Xiao Wang, Alexey Kim, Yevgeniy Kim, Aigul Sharip, Askarbek Orakov, Lixia Miao, Qinglei Sun, Yue Chen, Zhenbang Chen, Yingqiu Xie
Receptor tyrosine kinase EGFR usually is localized on plasma membrane to induce progression of many cancers including cancers in children (Bodey et al. In Vivo. 2005, 19:931-41), but it contains a nuclear localization signal (NLS) that mediates EGFR nuclear translocation (Lin et al. Nat Cell Biol. 2001, 3:802-8). Here we report that NLS of EGFR has its old evolutionary origin. Protein-protein interaction maps suggests that nEGFR pathways are different from membrane EGFR and EGF is not found in nEGFR network while androgen receptor (AR) is found, which suggests the evolution of prostate cancer, a well-known AR driven cancer, through changes in androgen- or EGF-dependence...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28379852/unmet-supportive-care-needs-of-men-with-locally-advanced-and-metastatic-prostate-cancer-on-hormonal-treatment-a-mixed-methods-study
#8
Catherine Paterson, Sławomir Grzegorz Kata, Ghulam Nandwani, Debi Das Chaudhury, Ghulam Nabi
BACKGROUND: Men affected by prostate cancer who are undergoing hormone therapy can endure a range of symptoms that can adversely affect quality of life. Little research has been conducted to date, to understand the specific unmet supportive care needs of this patient group within the context of current service delivery. OBJECTIVE: The aim of this study was to understand the experiences of unmet supportive care needs of men affected by prostate cancer on hormone therapy in the United Kingdom...
April 4, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28373430/ninjurin1-is-up-regulated-in-circulating-prostate-tumor-cells-and-plays-a-critical-role-in-prostate-cancer-cell-motility
#9
Juri Park, Jae-Young Joung, Ji-Eun Hwang, Dongwan Hong, Weon Seo Park, Sang-Jin Lee, Kang Hyun Lee
BACKGROUND/AIM: Ninjurin1 is a 17-kDa membrane protein that is highly expressed in circulating tumor cells (CTCs) obtained from locally-advanced prostate cancer patients. As CTCs are implicated in the initiation of distant metastasis, we examined the potential contribution of Ninjurin1 to the motility of prostate cancer cells. MATERIALS AND METHODS: Ninjurin1 expression was evaluated in CTCs harvested from seven locally advanced patients with no metastatic hallmarks using real-time polymerase chain reaction (PCR)...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373003/inhibition-of-the-rank-rankl-signaling-with-osteoprotegerin-prevents-castration-induced-acceleration-of-bone-metastasis-in-castration-insensitive-prostate-cancer
#10
Koichiro Takayama, Takamitsu Inoue, Shintaro Narita, Shinya Maita, Mingguo Huang, Kazuyuki Numakura, Hiroshi Tsuruta, Mitsuru Saito, Atsushi Maeno, Shigeru Satoh, Norihiko Tsuchiya, Tomonori Habuchi
Androgen deprivation therapy (ADT) for patients with metastatic or locally advanced prostate cancer reduces bone mineral density by stimulating receptor activator of nuclear factor kappa-B (RANK) signaling in osteoclasts. The involvement of the RANK/RANKL signaling in ADT-induced acceleration of bone metastasis in castration-insensitive prostate cancer was examined in a murine model using osteoprotegerin (OPG). Male Balb/c nude mice were divided into three groups: the non-castration, castration, and castration + OPG groups...
March 31, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28368893/early-detection-of-bilateral-testicular-metastases-from-prostatic-adenocarcinoma-using-68ga-psma-ligand-pet-ct
#11
Desiree Weiberg, Herbert Radner, Thorsten Derlin, Walter F Thon
We present the case of a 76-year-old man with biochemical relapse after primary therapy for prostate cancer. Ga prostate-specific membrane antigen (PSMA) ligand PET/CT performed for localization of recurrent disease revealed bilateral metastases to the testes. Histopathologic evaluation after bilateral orchiectomy revealed testicular metastases. Metastases to the testes are rare and usually seen in advanced stages. Ga-PSMA ligand PET/CT is a highly sensitive and specific imaging method for the detection of primary and metastatic prostate cancer and has refined diagnostic approaches...
March 31, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28362652/the-association-between-plasma-c-peptide-concentration-and-the-risk-of-prostate-cancer-a-nested-case-control-study-within-a-japanese-population-based-prospective-study
#12
Grace Y Kiyabu, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
The association between plasma C-peptide concentration and prostate cancer is unclear. Inconsistency of results from previous studies motivates this study. Using the Japan Public Health Center-based Prospective study, 201 prostate cancer cases and 402 controls were matched by age, public health center area, residence, date and time of blood collection, and fasting duration before blood collection. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated by conditional logistic regression models. Out of 201 cases, 144 were localized and 48 were advanced...
March 30, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28355119/high-intensity-focused-ultrasound-for-the-treatment-of-prostate-cancer-a-review
#13
Christian G Chaussy, Stefan Thüroff
Over the past 25 years, the average life expectancy for men has increased almost 4 years, and the age of prostate cancer detection has decreased an average of 10 years with diagnosis increasingly made at early-stage disease where curative therapy is possible. These changing trends in the age and extent of malignancy at diagnosis have revealed limitations in conventional curative therapies for prostate cancer, including a significant risk of aggressive cancer recurrence, and the risk of long-term genitourinary morbidity and its detrimental impact on patient's quality of life (QOL)...
April 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28351489/dying-for-love-perimenopausal-degeneration-of-vaginal-microbiome-drives-the-chronic-inflammation-malignant-transformation-of-benign-prostatic-hyperplasia-to-prostatic-adenocarcinoma
#14
Albert Stuart Reece
Prostatic carcinoma is the second commonest cancer in males and is so common as to become almost holoendemic with advancing age. The recent demonstration that far from being benign, "benign" prostatic hypertrophy is a likely a reaction of the prostate to chronic untreated lower genital tract infection, and that this chronic inflammation is likely the usual precursor to the frequent occurrence of prostatic carcinoma has far reaching implications. The obvious source for the chronic inflammatory stimulus in the prostate is the documented dramatically altered lower female genital microbiota associated with the menopause...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28349981/impact-of-urologists-ownership-of-radiation-equipment-in-the-treatment-of-prostate-cancer
#15
S B Williams, J Huo, B F Chapin, B D Smith, K E Hoffman
BACKGROUND: Physician practices that offer ancillary medical services may refer their patients for such services, a process known as self-referral. We wanted to evaluate how utilization and cost of care differ for men diagnosed with prostate cancer in a self-referral practice (SRP) compared to a traditional urologic practice. METHODS: A total of 17 982 men aged 66 years and older diagnosed with localized prostate cancer from 2006 to 2009 were identified from the Texas Cancer Registry...
March 28, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28349978/patient-selection-for-prostate-focal-therapy-in-the-era-of-active-surveillance-an-international-delphi-consensus-project
#16
K J Tay, M J Scheltema, H U Ahmed, E Barret, J A Coleman, J Dominguez-Escrig, S Ghai, J Huang, J S Jones, L H Klotz, C N Robertson, R Sanchez-Salas, S Scionti, A Sivaraman, J de la Rosette, T J Polascik
BACKGROUND: Whole-gland extirpation or irradiation is considered the gold standard for curative oncological treatment for localized prostate cancer, but is often associated with sexual and urinary impairment that adversely affects quality of life. This has led to increased interest in developing therapies with effective cancer control but less morbidity. We aimed to provide details of physician consensus on patient selection for prostate focal therapy (FT) in the era of contemporary prostate cancer management...
March 28, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28349755/radical-prostatectomy-for-locally-advanced-and-metastatic-prostate-cancer
#17
REVIEW
R Veeratterapillay, S S Goonewardene, J Barclay, R Persad, C Bach
The management of advanced prostate cancer remains challenging. Traditionally, radical prostatectomy was discouraged in patients with locally advanced or node positive disease owing to the increased complication rate and treatment related morbidity. However, technical advances and refinements in surgical techniques have enabled the outcomes for patients with high risk prostate cancer to be improved. More recently, the concept of cytoreductive prostatectomy has been described where surgery (often Combined with an extended lymph node dissection) is performed in the setting of metastatic disease...
April 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28349190/-when-should-the-primary-tumor-of-metastatic-bladder-or-prostate-cancer-be-treated-using-a-nonsurgical-regimen
#18
D Bottke, C Bolenz, S Ott, A Cebulla, T Wiegel
BACKGROUND: Patients with metastatic and locally advanced bladder or prostate cancer may suffer from pelvic symptoms such as pain, obstruction, and hemorrhage. Local tumor growth is associated with significant morbidity and systemic therapy is often ineffective. Local therapies such as bladder irrigation, transurethral resection of the prostate, and fulguration of bleeding vessels provide relief but often require repeated treatments. OBJECTIVES: The aim of this work was to review the current status of palliative pelvic radiotherapy for metastatic bladder and prostate cancer...
March 27, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28344813/the-modern-role-of-androgen-deprivation-therapy-in-the-management-of-localised-and-locally-advanced-prostate-cancer
#19
Charlotte Gunner, Aziz Gulamhusein, Derek J Rosario
INTRODUCTION: Approximately 50% of men diagnosed with prostate cancer will be exposed to androgen deprivation therapy (ADT) at some stage. The role of ADT in the management of metastatic disease has long been recognised, and its place in the management of localised and locally advanced disease has become clearer in the past few years. Nevertheless, concerns remain that some men might not benefit from ADT in earlier-stage disease. The purpose of the current article is to provide a brief narrative review of the role of ADT as part of a strategy of treatment with curative intent, concentrating mainly on key recent developments in the area...
December 2016: Journal of Clinical Urology
https://www.readbyqxmd.com/read/28323658/changing-face-of-metastatic-prostate-cancer-the-law-of-diminishing-returns-holds-true
#20
Ulka N Vaishampayan
PURPOSE OF REVIEW: Prostate cancer presents with a multitude of faces. It ranges from localized cancers staying quiescent for many years during active surveillance to the raging diffuse liver metastases causing terminal disease. The incidence of metastatic disease is increasing. This review will highlight some of the recent developments as well as ongoing challenges of managing advanced prostate cancer. RECENT FINDINGS: Significant strides are being made in managing metastatic prostate cancer...
March 18, 2017: Current Opinion in Oncology
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