Michelle R Tamplin, Jui-Kai Wang, Elaine M Binkley, Mona K Garvin, Daniel E Hyer, John M Buatti, H Culver Boldt, Isabella M Grumbach, Randy H Kardon
Optical coherence tomography (OCT) has become a key method for diagnosing and staging radiation retinopathy, based mainly on the presence of fluid in the central macula. A robust retinal layer segmentation method is required for identification of the specific layers involved in radiation-induced pathology in individual eyes over time, in order to determine damage driven by radiation injury to the microvessels and to the inner retinal neurons. Here, we utilized OCT, OCT-angiography, visual field testing, and patient-specific dosimetry models to analyze abnormal retinal layer thickening and thinning relative to microvessel density, visual function, radiation dose, and time from radiotherapy in a cross-sectional cohort of uveal melanoma patients treated with 125 I-plaque brachytherapy...
February 9, 2024: Scientific Reports