keyword
https://read.qxmd.com/read/38410107/case-report-a-rare-case-of-immunotherapy-induced-isolated-left-cn-vi-palsy-in-a-patient-with-unresectable-melanoma
#21
Samantha Su Ping Low, Karim El-Shakankery, Ewan Brown, Alan Christie, Sally McCormack, Mark Stares
INTRODUCTION: Immune checkpoint inhibitors are the mainstay of treatment in patients with unresectable or metastatic melanoma. Combination immunotherapy with ipilimumab and nivolumab has shown to improve survival outcomes as compared to single agent immunotherapy in these patients. Neurological immune-related adverse effects (irAEs) are uncommon and cranial nerve palsies are seen even more infrequently. CASE PRESENTATION: A 66-year-old woman with a background of metastatic, unresectable melanoma with supraclavicular and axillary lymph nodal involvement presented with a headache, photophobia and diplopia 3 weeks after her first cycle of ipilimumab and nivolumab...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38408223/trends-in-the-clinical-presentation-of-uveal-melanoma-during-the-covid-19-pandemic
#22
JOURNAL ARTICLE
Olufemi E Adams, Laurel B Tanke, Rusdeep Mundae, Guneet S Sodhi, Michael D Yu, Yoshihiro Yonekawa, Lauren A Dalvin, Peter H Tang
BACKGROUND AND OBJECTIVE: The objective was to evaluate factors associated with clinical presentation of uveal melanoma (UM) during the initial two years of the coronavirus disease 2019 pandemic. PATIENTS AND METHODS: This was a multi-site, retrospective cohort study of patients treated for uveal melanoma during the first (early) and second (late) year of the pandemic compared with the year prior (control). RESULTS: A total of 48, 67, and 75 patients were in the control, early, and late cohorts, respectively...
February 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38396026/challenges-in-diagnosing-canine-spindle-cell-tumours-using-immunohistochemistry-illustrated-by-three-nonpigmented-malignant-cases-from-the-nictitating-membrane
#23
JOURNAL ARTICLE
Kristine Bundgaard Kjellingbro, Carolina Naranjo Freixa, Lauge Hjorth Mikkelsen, Steffen Heegaard
BACKGROUND: Nonpigmented malignant spindle cell tumours of the membrana nictitans are rare in dogs. In twenty-three years only three cases have been diagnosed in Scandinavia. This study describes the three cases of malignant tumours of the membrana nictitans recorded by the Eye Pathology Section, University of Copenhagen, Denmark, with reference to the clinical appearance and work-up, the treatment and prognosis, and the histopathological description including immunohistochemistry. The three cases are compared to previous publications on canine tumours of the nictitating membrane...
February 23, 2024: Acta Veterinaria Scandinavica
https://read.qxmd.com/read/38394461/blink-of-an-eye-evaluating-dermatologist-s-speed-versus-accuracy-for-melanoma-diagnosis
#24
JOURNAL ARTICLE
Joshua Burshtein, Milaan Shah, Danny Zakria, Darrell Rigel
BACKGROUND: Detection of melanoma at an early stage is critical to optimize surgical removal outcomes. The time to accurately visually diagnose melanoma has not been studied. OBJECTIVE: To evaluate dermatologists' speed versus accuracy of melanoma diagnosis. METHODS: A cross-sectional study with a 20-question quiz was conducted at a national dermatology conference. Questions were asked to identify either melanoma or benign lesion. The first 10 lesions were shown for 4 seconds each, and the next 10 were shown for 0...
February 23, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38390435/conjunctival-nevus
#25
JOURNAL ARTICLE
Jaxon J Huang, Elyana V T Locatelli, Alberto Chocron, Matthew R Camacho, Sander Dubovy, Carol L Karp, Anat Galor
PURPOSE OF REVIEW: To provide an up-to-date review of the epidemiology, presentation, diagnosis, and treatment options for conjunctival nevi (CN). RECENT FINDINGS: Around 17.2%-42% of all conjunctival tumors have been found to be CN, which most frequently present in White individuals between the first to early third decade of life, with equal distribution between males and females. CN commonly occur in the interpalpebral bulbar conjunctiva with pigmentation ranging from amelanotic to dark...
December 2023: Current Ophthalmology Reports
https://read.qxmd.com/read/38385179/eight-weeks-of-exercise-intervention-improve-visuomotor-and-functional-capacity-performance-and-physiological-profile-in-a-choroidal-melanoma-patient
#26
JOURNAL ARTICLE
Michael Mendes Wefelnberg, Madeline Moll, Philipp von Stein, Henning Guthoff, Ludwig M Heindl, Philomena Wawer Matos Reimer, Alexander C Rokohl, Michael Simon, Damir Zubac, Freerk T Baumann
The aim of this case-study was to investigate the effects of an 8-week combined exercise intervention, consisting of visual-coordinative and high-intensity interval training (HIIT), on the physical and visuomotor-functional capacity, performance, and physiological profile of a moderately active 29-year-old man diagnosed with choroidal melanoma of the left eye. Data were collected on three occasions: at the initial diagnosis (T0), after hospitalization and radiotherapy treatment (T1), and following the recovery through the exercise intervention (T2), spanning a total of 17 weeks...
February 22, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38383076/impact-of-iris-color-on-uveal-melanoma-related-outcomes-in-7245-patients-at-a-single-ocular-oncology-center
#27
JOURNAL ARTICLE
Alexandra R Zaloga, Charles DeYoung, Deepthi E Kurian, Kevin R Card, G Brandon Caudill, Jennifer S Zeiger, Carol L Shields
PURPOSE: To determine the relationship between iris color and uveal melanoma (UM)-related metastasis and death in a large cohort of patients from a single ocular oncology center. DESIGN: Retrospective case series. SUBJECTS: Patients diagnosed with UM between February 1971 and August 2007. METHODS: Patient information was obtained from chart documentation. MAIN OUTCOME MEASURES: UM-related metastasis and death...
2024: Asia-Pacific Journal of Ophthalmology
https://read.qxmd.com/read/38376095/tissue-glue-adhesion-for-plaque-radiotherapy-of-uveal-melanoma-in-humans-an-initial-experience
#28
JOURNAL ARTICLE
Kushal U Agrawal, Nicholas E Kalafatis, Konica Singla, Sara E Lally, Carol L Shields
PURPOSE: The aims of this study were to study use of tissue glue instead of conventional suturing and to secure I-125 plaque in human eyes with uveal melanoma. METHODS: We studied 6 patients with choroidal melanoma undergoing plaque radiotherapy who were found to have thin sclera intraoperatively. Following tumor localization and plaque placement, tissue glue was applied over and around the plaque surface. The plaque was held securely in all cases. Conjunctivoplasty was performed with 7-0 vicryl sutures to ensure complete coverage and stability of the plaque...
August 2023: Ocular Oncology and Pathology
https://read.qxmd.com/read/38376093/edge-creep-increased-pigmentation-at-the-border-of-choroidal-melanomas-treated-with-plaque-brachytherapy
#29
JOURNAL ARTICLE
Elaine M Binkley, Sean M Rodriguez, Daniel E Hyer, Connie J Hinz, H Culver Boldt
INTRODUCTION: There is an increase in pigmentation that occurs in many tumors following plaque brachytherapy for choroidal melanoma. Correctly distinguishing between increased pigment at the tumor border versus true growth is imperative. We performed a retrospective review of patients treated with I-125 brachytherapy for choroidal melanoma at our institution to study this phenomenon. METHODS: Records were reviewed for all patients undergoing plaque brachytherapy for uveal melanoma for a 5-year period ( N = 195)...
August 2023: Ocular Oncology and Pathology
https://read.qxmd.com/read/38376089/is-tumour-thickness-measurement-required-for-moles-scoring-of-melanocytic-choroidal-tumours
#30
JOURNAL ARTICLE
Jared Ching, Lamis AlHarby, Mandeep S Sagoo, Bertil Damato
INTRODUCTION: It can be challenging to distinguish between choroidal naevi and melanomas in the community setting, particularly without access to ultrasonography (US), required to measure the thickness of melanocytic choroidal tumours. We aimed to determine whether thickness measurement is required for MOLES scoring of melanocytic choroidal tumours. METHODS: The dataset of a recent MOLES evaluation was reviewed. Patients were selected for the present study if their MOLES tumour size category was determined by tumour thickness measured with US...
August 2023: Ocular Oncology and Pathology
https://read.qxmd.com/read/38376083/ultrasound-verification-of-plaque-brachytherapy-placement-in-patients-treated-for-primary-uveal-melanoma-a-single-center-experience
#31
JOURNAL ARTICLE
Joseph M Grimes, Henry Zhou, Alexis K Dal Col, Alexandra Gershkovich, Dmitry Bogomolny, Brian P Marr
INTRODUCTION: Proper plaque positioning is essential for effective episcleral plaque brachytherapy and can be verified using ultrasound. In this study, we show our center's protocol for intraoperative ultrasound verification of plaque placement and present our single-center local recurrence data in patients with primary UM involving the choroid and/or ciliary body. We also indicate our center's distance metastasis rate for patients presenting with primary UM. METHODS: All patients who presented to our institution with UM of the choroid and/or ciliary body between May 2017 and March 2022 and treated with plaque brachytherapy were enrolled...
August 2023: Ocular Oncology and Pathology
https://read.qxmd.com/read/38362357/lacrimal-drainage-system-and-nasal-cavity-melanoma-after-complete-treatment-of-conjunctival-melanoma
#32
Amirreza Veisi, Zahra Dastborhan, Mohsen Dastmardi, Mozhgan Rezaie Kanavi, Saeid Rezaei
Malignant melanoma of the conjunctiva is a rare tumor of the ocular surface with potential fatal consequences and a high likelihood of recurrence. Although routes for extending the tumor, including local, hematogenous, and lymphatogenous, are pretty straightforward, the indirect extension through free-floating tumoral cells to the nasolacrimal duct is not described thoroughly. We report a case of malignant melanoma of the conjunctiva which presented with local recurrence in the intranasal cavity and lacrimal sac two years after the primary surgery (without involvement of the ocular surface and punctum on the second occasion)...
2024: Case Reports in Ophthalmological Medicine
https://read.qxmd.com/read/38357672/stereotactic-radiotherapy-for-uveal-melanoma-a-case-report
#33
Nidal Salim, Ilya Loyko, Kristina Tumanova, Aleksander Stolbovoy, Oksana Levkina, Igor Prokofev
Uveal melanoma (UM) is the most common primary intraocular malignancy worldwide. Surgical intervention and radiation therapy (RT) are the primary treatment options. Given the complexity and cosmetic discomfort associated with eye enucleation, this method is less frequently used. As a result, RT, including photon therapy, proton therapy and brachytherapy, has become the treatment of choice. Traditionally, plaque brachytherapy has been the most commonly used in clinical practice. However, the question of which type of radiation therapy is the most effective, safe, commonly available and cost-effective remains open...
March 2024: Molecular and Clinical Oncology
https://read.qxmd.com/read/38353266/equivalent-uniform-rbe-weighted-dose-in-eye-plaque-brachytherapy
#34
JOURNAL ARTICLE
Alexei V Chvetsov
BACKGROUND: Brachytherapy for ocular melanoma is based on the application of eye plaques with different spatial dose nonuniformity, time-dependent dose rates and relative biological effectiveness (RBE). PURPOSE: We propose a parameter called the equivalent uniform RBE-weighted dose (EUDRBE ) that can be used for quantitative characterization of integrated cell survival in radiotherapy modalities with the variable RBE, dose nonuniformity and dose rate. The EUDRBE is applied to brachytherapy with 125 I eye plaques designed by the Collaborative Ocular Melanoma Study (COMS)...
February 14, 2024: Medical Physics
https://read.qxmd.com/read/38351125/ambient-ultraviolet-radiation-and-ocular-melanoma-incidence-in-the-united-states-2000-2019
#35
JOURNAL ARTICLE
Basilica M Arockiaraj, Elizabeth K Cahoon, Michael R Sargen, Erping Long, Margaret A Tucker, Jim Z Mai
BACKGROUND/OBJECTIVES: Ocular melanoma is a rare, but deadly cancer. This large cancer registry study examines the associations between solar ultraviolet radiation (UVR) and incidence of different anatomical sites of ocular melanoma by sex, age, laterality, and race and ethnicity. METHODS: Incidence data were derived from 21 cancer registries in the US for the years 2000-2019. Satellite-based UVR estimates were linked to county of residence at diagnosis. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quartiles using Poisson models...
February 13, 2024: Eye
https://read.qxmd.com/read/38347180/local-anaesthesia-under-sedation-versus-general-anaesthesia-for-brachytherapy-treated-patients-with-uveal-melanoma-a-patient-reported-outcome-study
#36
JOURNAL ARTICLE
Max Davidson, Alastair Glossop, Hibba Quhill
No abstract text is available yet for this article.
February 12, 2024: Eye
https://read.qxmd.com/read/38342795/foxm1-promote-the-growth-and-metastasis-of-uveal-melanoma-cells-by-regulating-cdk2-expression
#37
JOURNAL ARTICLE
Xue Bai, Shan Li, Yan Luo
BACKGROUND: Uveal melanoma (UVM) is an aggressive malignant tumor originating from melanocytes in the eye. Here, we screened the possible genes involved in the development and prognosis of UVM, and identified that FOXM1 and MET were associated with the prognosis of UVM patients. Forkhead box protein M1 (FOXM1) is a transcription factor that regulates the expression of cell cycle-related genes that are necessary for DNA duplication. However, the regulatory mechanism of FOXM1 in UVM was still not clear...
February 11, 2024: International Ophthalmology
https://read.qxmd.com/read/38342335/gsdmd-mediated-pyroptosis-induced-inflammation-of-graves-orbitopathy-via-the-nf-%C3%AE%C2%BAb-aim2-caspase-1-pathway
#38
JOURNAL ARTICLE
Xiaotong Sha, Huijing Ye, Xing Wang, Zhihui Xu, Anqi Sun, Wei Xiao, Te Zhang, Shenglan Yang, Huasheng Yang
Gasdermin D (GSDMD) is a key executor which triggers pyroptosis as well as an attractive checkpoint in various inflammatory and autoimmune diseases but it has yet to prove its function in Graves'orbitopathy (GO). Our aim was to investigate GSDMD levels in orbital connective tissue and serum of GO patients and then assess the association between serum levels and patients' clinical activity score (CAS). Further, GSDMD-mediated pyroptosis and the underlying mechanism in inflammatory pathogenesis in the cultured orbital fibroblasts (OFs) of GO patients were examined...
February 9, 2024: Experimental Eye Research
https://read.qxmd.com/read/38336828/radiation-effects-on-retinal-layers-revealed-by-oct-oct-a-and-perimetry-as-a-function-of-dose-and-time-from-treatment
#39
JOURNAL ARTICLE
Michelle R Tamplin, Jui-Kai Wang, Elaine M Binkley, Mona K Garvin, Daniel E Hyer, John M Buatti, H Culver Boldt, Isabella M Grumbach, Randy H Kardon
Optical coherence tomography (OCT) has become a key method for diagnosing and staging radiation retinopathy, based mainly on the presence of fluid in the central macula. A robust retinal layer segmentation method is required for identification of the specific layers involved in radiation-induced pathology in individual eyes over time, in order to determine damage driven by radiation injury to the microvessels and to the inner retinal neurons. Here, we utilized OCT, OCT-angiography, visual field testing, and patient-specific dosimetry models to analyze abnormal retinal layer thickening and thinning relative to microvessel density, visual function, radiation dose, and time from radiotherapy in a cross-sectional cohort of uveal melanoma patients treated with 125 I-plaque brachytherapy...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38324631/brca-associated-protein1-bap1-immunohistochemical-stain-reliability-in-postbrachytherapy-uveal-melanoma-enucleation-specimens
#40
JOURNAL ARTICLE
Maya Eiger-Moscovich, Carol L Shields, Ralph C Jr Eagle, Tatyana Milman
PURPOSE: The BRCA-associated protein1 (BAP1) immunohistochemical (IHC) stain has emerged as a powerful and inexpensive prognostic tool in uveal melanoma (UM), correlating with UM genetics and outcome. The data on the reliability of BAP1 immunohistochemistry in previously irradiated UM is scant. We aim to assess BAP1 IHC in post-Iodine-125 plaque brachytherapy-treated UM-enucleated eyes. METHODS: In a case-control study, the medical records of all patients who underwent enucleation for UM at a major Ocular Oncology Service from December 1st, 2007 to December 31st, 2014 were reviewed...
February 5, 2024: Indian Journal of Ophthalmology
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