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https://www.readbyqxmd.com/read/29145341/primary-malignant-melanoma-of-the-gallbladder-with-multiple-metastases-a-case-report
#1
Jun-Ke Wang, Fei Su, Wen-Jie Ma, Hai-Jie Hu, Qin Yang, Fei Liu, Quan-Sheng Li, Fu-Yu Li
RATIONAL: Primary malignant melanoma of the gallbladder is an extremely rare tumor, with fewer than 40 cases reported in the literature worldwide. The majority of patients presented as a solitary lesion in the gallbladder. To our knowledge, only one case of primary malignant melanoma of the gallbladder with multiple metastases has been reported, which involved the stomach, duodenum, pancreas, jejunum and a mesenteric lymph node. PATIENT CONCERNS: We report a case of primary malignant melanoma of the gallbladder with metastases to the duodenal bulb, right adrenal and a celiac lymph node...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142760/outcomes-of-primary-endoresection-for-choroidal-melanoma
#2
Andre A C Vidoris, Andre Maia, Marcia Lowen, Melina Morales, Jordan Isenberg, Bruno F Fernandes, Rubens N Belfort
Purpose: To review long time treatment results in patients with small or medium sized choroidal melanoma who underwent surgical tumor endoresection as a primary treatment when plaque radiotherapy was unable and patients declined enucleation. Materials and methods: Patients were evaluated for best corrected visual acuity (BCVA), and underwent biomicroscopy, indirect ophthalmoscopy, retinography and ultrasound as well as the usual systemic workup. Study inclusion required the absence of scleral invasion or metastasis and an anterior margin not exceeding the pars plana or the ciliary body...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29139486/simple-and-rapid-colorimetric-detection-of-melanoma-circulating-tumor-cells-using-bifunctional-magnetic-nanoparticles
#3
Junrong Li, Jing Wang, Yuling Wang, Matt Trau
Circulating tumor cells (CTCs) are a promising biomarker for monitoring cancer metastasis and therapy response. However, the rarity and inherent fragility of CTCs pose great challenges for CTC detection. Currently, CTC detection requires advanced instruments that might be inaccessible in most hospitals or labs. To allow simple and rapid CTC detection, we propose a sensor platform that relies only on the intrinsic properties of magnetic nanoparticles (MNPs) including rapid separation as well as nanozyme activity...
November 15, 2017: Analyst
https://www.readbyqxmd.com/read/29128996/e-derma-a-novel-wireless-dermatoscopy-system
#4
Bogdan Dugonik, A Dugonik, D Horvat, B Žalik, D Špelič
Cutaneous Melanoma (CM) is a malignant tumour, and is one of the most rapidly growing cancers. Discovering a melanoma in the early stages of the disease is extremely difficult and, as such, only an invasive disease stage can be identified easily with the naked eye. Dermatoscopy is a diagnostic method intended to maximise early detection of CM performed by the dermatoscopy system. To address the limitations of existing systems a novel, wireless digital dermatoscopy system is presented for providing high-resolution images...
November 11, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29122824/ruthenium-106-brachytherapy-for-iris-and-iridociliary-melanomas
#5
Marina Marinkovic, Nanda Horeweg, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Femke P Peters, Gre P M Luyten, Carien L Creutzberg
BACKGROUND AND PURPOSE: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). MATERIALS AND METHODS: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). RESULTS: Overall median follow-up was 36 months...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29118486/choroidal-melanoma-a-short-review-with-an-indian-perspective
#6
REVIEW
Bikramjit P Pal, Saili Garge, Vikas Khetan
Choroidal melanoma (CM), the most common intraocular tumor in adults, is still a rarity in Asia. Having a high propensity for metastasis with a poor survival, recognizing it early is essential. Although it has typical clinical features, there are instances of simulating lesions. Fine-needle aspiration biopsy can be a valuable tool not only to confirm our clinical suspicion but also aid in prognosticating it. From days of histopathological prognostic markers, we are moving on to genetic markers which are reliably providing insights, helping us in providing a better care for our patients...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29116399/intravitreal-bevacizumab-for-neovascular-glaucoma-in-uveal-melanoma-treated-by-proton-beam-therapy
#7
Amir Mahdjoubi, Marie Najean, Stéphanie Lemaitre, Sylvain Dureau, Rémi Dendale, Christine Levy, Livia Lumbroso-Le Rouic, Laurence Desjardins, Nathalie Cassoux
BACKGROUND: To evaluate the efficacy of bevacizumab on reduction of the enucleation rate and control of intraocular pressure (IOP) in neovascular glaucoma (NVG)-complicating proton beam therapy for UM and to identify the determinants of the efficacy of bevacizumab. METHODS: Retrospective comparative study of patients with rubeosis following proton therapy for uveal melanoma. Patients were divided into two groups: a bevacizumab group and a control group which comprised two subgroups: panretinal photocoagulation (PRP)/cryotherapy and observation subgroups...
November 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29111820/identification-of-feeder-vessels-in-ocular-surface-neoplasia-using-indocyanine-green-angiography
#8
Matthias Brunner, Bernhard Steger, Vito Romano, Martin Hodson, Yalin Zheng, Heinrich Heimann, Stephen B Kaye
PURPOSE: To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS: Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of the bulbar conjunctiva were included. Patients underwent anterior segment optical coherence tomography, ICGA, and color photography for the evaluation of the thickness, location, number, and diameter of afferent and efferent vessels of the lesions...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29109715/specific-detection-of-serum-antibodies-against-bkpyv-a-small-dna-tumour-virus-in-patients-affected-by-choroidal-nevi
#9
Silvia Pietrobon, Ilaria Bononi, Francesca Lotito, Paolo Perri, Sara Violanti, Elisa Mazzoni, Fernanda Martini, Mauro G Tognon
Ocular or choroidal nevus (CN) is a rare benign neoplastic lesion of the eye. The cause of CN onset/progression, which arises from the transformation of ocular melanocytes, is not known. A fraction of CN patients may develop uveal melanoma. The objective of this study was to investigate the association between CN and BK polyomavirus (BKPyV), a small DNA tumor virus. Serum IgG antibodies which react with BKPyV antigens were analyzed. An indirect E.L.I.S.A. using synthetic peptides that mimic BKPyV antigens was employed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29104697/novel-surgical-approach-in-cutaneous-melanoma-patients-daring-ideas-are-like-chessmen-moved-forward-they-may-be-beaten-but-they-may-start-a-winning-game
#10
Georgi Tchernev
For the first time, but again, we propose the idea of a one-step melanoma surgery as a "golden, unified standard" that should be at least discussed and, possibly accepted shortly as the "gold standard" for the treatment of patients with skin melanomas. Critical points or comments have been made to the current melanoma's treatment approach, which has been "transcendently followed" for years and which, according to some colleagues, is not logically justified. This approach needs serious changes, the only goal of which is to achieve a better outlook for the patients...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29095741/eccrine-centric-melanocytic-nevus
#11
Raymond M Fertig, Adar Berghoff, Jessica Cervantes, Evan Darwin, Drazen Jukic
Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. The patient was a 50-year-old African American woman who noticed a new mole on her foot that began as a dark speck but quickly grew larger. The lesion was excised to exclude the possibility of melanoma...
October 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29071276/small-choroidal-melanoma-revealed-by-a-large-extrascleral-extension
#12
Stéphanie Lemaître, Mathieu Zmuda, Pierre Vincent Jacomet, Christine Lévy-Gabriel, Rémi Dendale, Olivier Berges, Paul Fréneaux, Pascale Mariani, Laurence Desjardins, Olivier Galatoire, Nathalie Cassoux
AIMS: Orbital extraocular extension of choroidal melanoma is very rare with small melanomas. We report the case of a patient whose small choroidal melanoma was initially overlooked and was revealed by a large extrascleral extension. METHODS: A 48-year-old Caucasian woman presented with sudden total visual loss in the right eye. Multicolor imaging of the fundus showed right optic disc edema and an orange and green lesion near the optic disc. The diagnosis of unilateral optic neuritis was made...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071272/conjunctival-blue-naevus-in-an-anophthalmic-socket
#13
Hibba Quhill, Paul A Rundle, Hardeep Singh Mudhar
PURPOSE OF THE STUDY: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. PROCEDURES: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071268/development-of-ocular-rosacea-following-combined-ipilimumab-and-nivolumab-treatment-for-metastatic-malignant-skin-melanoma
#14
Niels J Brouwer, John B A G Haanen, Martine J Jager
PURPOSE: To report a case of severe ocular rosacea following ipilimumab plus nivolumab treatment in a patient with metastatic malignant skin melanoma. METHODS: Case report and review of the literature. RESULTS: A 68-year-old male with newly diagnosed metastatic malignant cutaneous melanoma was treated with first-line ipilimumab plus nivolumab, which resulted in a partial response. Four months after initiation of treatment, the patient developed red eyelids and conjunctivae, with painful gritty eyes, limiting his capacity to read...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071267/uveal-melanoma-cell-seeding-after-transretinal-tumor-biopsy
#15
Konrad R Koch, Ahmed M Hishmi, Monika Ortmann, Ludwig M Heindl
BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. METHODS: Interventional case report. RESULTS: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29059951/fully-automated-blink-detection-for-uveal-melanoma-radiotherapy
#16
Melih Cavusculu, Imam Samil Yetik, Mete Yeginer
Uveal melanoma is a widespread neoplasm in the eye that cause vision defects. The disease may result in loss of eye, even loss of life with a risk of metastasis to other tissues. There have been proposed various treatment methods to overcome the disease including enucleation and radiotherapy. Radiotherapy treatment is certainly preferable since it avoids the loss of eye. The treatment is applied with radioactive beam directed to the tumor, and thus the eye must be kept steady usually with local anesthesia. However, anesthesia has many health risks; therefore it is preferable to perform this operation without it...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059312/conjunctival-melanoma-in-chinese-patients-local-recurrence-metastasis-mortality-and-comparisons-with-caucasian-patients
#17
COMPARATIVE STUDY
Chuandi Zhou, Yuxin Wang, Renbing Jia, Xianqun Fan
Purpose: To evaluate the prognosis in Chinese patients with conjunctival melanoma and determine its predictors. Further, to explore the racial differences in clinical characteristics and outcomes between Chinese and Caucasian patients. Methods: This cohort study included 57 eyes of 57 consecutive patients with pathologically verified conjunctival melanoma between 1996 and 2016. Medical records were reviewed for factors associated with the local recurrence, metastasis, and tumor-related mortality...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29052750/impact-of-a-cd4-gene-haplotype-on-the-immune-response-in-minipigs
#18
Fany Blanc, Françoise Créchet, Nicolas Bruneau, Guillaume Piton, Jean-Jacques Leplat, Fabrice Andréoletti, Giorgia Egidy, Silvia Vincent-Naulleau, Emmanuelle Bourneuf
The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive sequencing revealed a high genetic variability of CD4 and the existence of several haplotypes segregating in MeLiM. Forty polymorphisms were identified in the coding sequence, out of which 20 correspond to non-synonymous variants and 10 are located in the 3'UTR of CD4 transcripts...
October 20, 2017: Immunogenetics
https://www.readbyqxmd.com/read/29049518/long-term-outcomes-after-proton-beam-irradiation-in-patients-with-large-choroidal-melanomas
#19
Thanos D Papakostas, Anne Marie Lane, Margaux Morrison, Evangelos S Gragoudas, Ivana K Kim
Importance: Although radiotherapy has been used more frequently in past decades for the management of large melanomas, long-term efficacy of proton beam irradiation (PBI) of large choroidal melanomas has not been reported. Objective: To evaluate long-term outcomes in patients who underwent PBI for the treatment of large choroidal melanomas. Design, Setting, and Participants: Data were obtained at a single Boston, Massachusetts, academic tertiary referral practice for this retrospective cohort study...
November 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29038913/-ocular-melanomas-an-update
#20
REVIEW
H Kalirai, P L Müller, D Jaehne, S E Coupland
Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression...
November 2017: Der Pathologe
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