keyword
https://read.qxmd.com/read/38492668/vitreous-metastasis-from-cutaneous-melanoma-while-on-checkpoint-inhibitors
#1
JOURNAL ARTICLE
Thomas M Catapano, Rolika Bansal, Carol L Shields
No abstract text is available yet for this article.
March 14, 2024: Asia-Pacific Journal of Ophthalmology
https://read.qxmd.com/read/38482451/development-and-validation-of-a-nomogram-to-predict-overall-survival-of-conjunctival-melanoma-a-population-based-study
#2
JOURNAL ARTICLE
Yuan Peng, Lingmei Yuan, Shipeng Zou, Yanwei Li, Shengzhi Tong, Binglin Huang
BACKGROUND: Conjunctival melanoma (CM) is a rare, invasive tumor in the eye that readily metastasizes and spreads. Based on some significant clinicopathological information, we aimed to develop a prognostic model to predict the overall survival (OS) of CM patients. METHODS: Data of patients diagnosed with CM from 2000 to 2019 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Significant prognostic factors were extracted and integrated based on competing risk regression to build a nomogram...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38476800/diagnostic-challenges-of-sinonasal-pleomorphic-adenoma
#3
Stefan Konsulov, Denis Milkov, Daniel Markov, Elena G Poryazova
Pleomorphic adenomas (PAs) are benign tumors of the salivary glands. Rarely, they arise in the sinonasal cavity, presenting as well-defined, homogeneous soft tissue masses, causing expansive bony changes. The significance of PAs is the possibility of giving rise to malignant carcinoma - "carcinoma ex-pleomorphic adenoma" (CXPA).Here, we present the case of a 64-year-old female complaining of progressive unilateral congestion and external nose deformation, mostly along the left contour of the radix, with epiphora of the ipsilateral eye...
February 2024: Curēus
https://read.qxmd.com/read/38473430/current-and-emerging-radiotherapy-options-for-uveal-melanoma
#4
REVIEW
Oleksii Semeniuk, Esther Yu, Mark J Rivard
What treatment options are there for patients having uveal melanoma? A randomized, prospective, multi-institutional clinical trial (COMS) showed no difference in survival between brachytherapy and enucleation for medium-sized lesions. With the obvious benefit of retaining the eye, brachytherapy has flourished and many different approaches have been developed such as low-dose-rate sources using alternate low-energy photon-emitting radionuclides, different plaque designs and seed-loading techniques, high-dose-rate brachytherapy sources and applicators, and low- and high-dose-rate beta-emitting sources and applicators...
March 6, 2024: Cancers
https://read.qxmd.com/read/38472933/a-european-multicentric-investigation-of-atypical-melanocytic-skin-lesions-of-palms-and-soles-the-idscore-palmoplantar-database
#5
JOURNAL ARTICLE
Linda Tognetti, Alessandra Cartocci, Aimilios Lallas, Elvira Moscarella, Ignazio Stanganelli, Gianluca Nazzaro, John Paoli, Maria Concetta Fargnoli, Paolo Broganelli, Harald Kittler, Jean-Luc Perrot, Gennaro Cataldo, Gabriele Cevenini, Sofia Lo Conte, Leonardelli Simone, Elisa Cinotti, Pietro Rubegni
Background: The differential diagnosis of atypical melanocytic palmoplantar skin lesions (aMPLs) represents a diagnostic challenge, including atypical nevi (AN) and early melanomas (MMs) that display overlapping clinical and dermoscopic features. We aimed to set up a multicentric dataset of aMPL dermoscopic cases paired with multiple anamnestic risk factors and demographic and morphologic data. Methods: Each aMPL case was paired with a dermoscopic and clinical picture and a series of lesion-related data (maximum diameter value; location on the palm/sole in 17 areas; histologic diagnosis; and patient-related data (age, sex, family history of melanoma/sunburns, phototype, pheomelanin, eye/hair color, multiple/dysplastic body nevi, and traumatism on palms/soles)...
February 20, 2024: Diagnostics
https://read.qxmd.com/read/38472430/drusen-in-the-macula-and-parapapillary-region
#6
JOURNAL ARTICLE
Jost B Jonas, Songhomitra Panda-Jonas, Rahul A Jonas
PURPOSE: To examine histological characteristics and differences between drusen beneath the retinal pigment epithelium (small hard drusen) located in the macula and located in the parapapillary region. METHODS: We histomorphometrically examined human eyes enucleated due to uveal melanomas or secondary angle-closure glaucoma. RESULTS: The study included 106 eyes (age, 62.6 ± 15.2 years) with macular drusen (n = 7 globes) or parapapillary drusen (n = 29 eyes) and 70 eyes without drusen...
March 13, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38467992/cystoid-macular-oedema-in-a-patient-treated-with-sting-agonist-and-ezabenlimab-for-disseminated-melanoma
#7
JOURNAL ARTICLE
Peter Kiraly, M Dominik Fischer
INTRODUCTION: We describe a case of cystoid macular oedema associated with combination treatment using a STING agonist and ezabenlimab for disseminated melanoma. CASE REPORT: A 66-year-old male patient presented with worsening vision and cystoid macular oedema in the right eye, along with a small accumulation of subretinal fluid in the left eye. The patient has been undergoing treatment for melanoma since 2014. Five months prior to the ocular presentation, the patient was enrolled in a first-in-human trial with a STING agonist and ezabenlimab...
March 11, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38467968/mitochondrial-damage-and-clearance-in-retinal-pigment-epithelial-cells
#8
JOURNAL ARTICLE
Iswariyaraja Sridevi Gurubaran
Age-related macular degeneration (AMD) is a devastating eye disease that causes permanent vision loss in the central part of the retina, known as the macula. Patients with such severe visual loss face a reduced quality of life and are at a 1.5 times greater risk of death compared to the general population. Currently, there is no cure for or effective treatment for dry AMD. There are several mechanisms thought to underlie the disease, for example, ageing-associated chronic oxidative stress, mitochondrial damage, harmful protein aggregation and inflammation...
March 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38462378/-a-giant-malignant-melanoma-of-the-palpebral-conjunctiva-a-case-report
#9
JOURNAL ARTICLE
X H Zhang, Z Yang, Y Lu, Z H Feng
An 81-year-old female patient experienced a rapid increase in the volume of a rice-sized black mass on the left eye over a period of six months. The mass extended out of the eye and exhibited surface erosion with accompanying hemorrhage. Following a live tissue examination and histopathology after orbital exenteration under general anesthesia, the diagnosis of a giant malignant palpebral conjunctival melanoma of the spindle cell subtype was confirmed. The patient refused to undergo local radiation therapy or systemic chemotherapy and died from the disease six months later...
March 11, 2024: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/38458998/precise-readout-of-mek1-proteoforms-upon-mapk-pathway-modulation-by-individual-ion-mass-spectrometry
#10
JOURNAL ARTICLE
Bryon S Drown, Raveena Gupta, John P McGee, Michael A R Hollas, Paul J Hergenrother, Jared O Kafader, Neil L Kelleher
The functions of proteins bearing multiple post-translational modifications (PTMs) are modulated by their modification patterns, yet precise characterization of them is difficult. MEK1 (also known as MAP2K1) is one such example that acts as a gatekeeper of the mitogen-activating protein kinase (MAPK) pathway and propagates signals via phosphorylation by upstream kinases. In principle, top-down mass spectrometry can precisely characterize whole MEK1 proteoforms, but fragmentation methods that would enable the site-specific characterization of labile modifications on 43 kDa protein ions result in overly dense tandem mass spectra...
March 8, 2024: Analytical Chemistry
https://read.qxmd.com/read/38457580/conjunctival-myxoma-a-case-report-and-review-of-a-rare-tumor
#11
JOURNAL ARTICLE
Seong Eun Lee, Sung Bok Lee, Kyunghee Kim, Jae Yun Sung
RATIONALE: Conjunctival myxoma is a rare benign tumor, which can mimic more common conjunctival lesions such as a cyst, lymphangioma, amelanotic nevus, neurofibroma, amelanotic melanoma, or lipoma. We describe a patient with the conjunctival myxoma, who was initially misdiagnosed as a conjunctival cyst. This case report includes intraoperative photographs and various immunohistochemical staining images. PATIENTS CONCERNS: A 55-year-old woman presented with a painless mass in the superotemporal conjunctiva of the left eye, which she had noticed 1 month ago...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38453030/diffuse-preretinal-vitreous-seeding-as-a-recurrence-of-uveal-melanoma
#12
JOURNAL ARTICLE
L Yamamoto-Rodríguez, D Lorenzo, R Mediavilla-Vallespín, J M Caminal
No abstract text is available yet for this article.
March 5, 2024: Asia-Pacific Journal of Ophthalmology
https://read.qxmd.com/read/38452261/pembrolizumab-related-bilateral-ocular-hypotony-associated-with-ciliary-detachments-and-macula-oedema-a-treatment-resistant-side-effect
#13
JOURNAL ARTICLE
Louise Bec, Charles Khouri, Christophe Chiquet
PURPOSE: To report of a case of bilateral ocular hypotony associated with ciliary detachments and macula edema as an uncommon troublesome side-effect of pembrolizumab (an immune checkpoint inhibitor) treatment. METHODS: A 56-year-old man with a history of metastatic axillary melanoma (bone, lung, spleen and lymph node lesions) treated with pembrolizumab complained of visual deterioration at his first-year anti-PD1 follow-up visit. Visual acuity in both eyes was 20/32...
March 6, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38444640/clearance-of-plasma-cell-free-dna-in-metastatic-uveal-melanoma-with-radiographic-response-to-immune-checkpoint-inhibitors
#14
Jasmine H Francis, Christopher A Barker, Julia Canestraro, David H Abramson, Alexander N Shoushtari
PURPOSE: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment. OBSERVATIONS: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38431268/combined-photodynamic-therapy-and-transpupillary-thermotherapy-for-small-choroidal-melanoma
#15
REVIEW
Olivia J Rolfe, Andrew L Stark, Hayley R Hamilton, Matthew D'Mellow, Jane M Palmer, Lindsay A McGrath, Sunil K Warrier, William J Glasson
OBJECTIVE: The objective of this study was to determine whether combining verteporfin-based photodynamic therapy (PDT) and transpupillary thermotherapy (TTT) achieves adequate tumour control while maintaining visual acuity in individuals with small choroidal melanoma of amelanotic, melanotic, and variable pigmentation. DESIGN: Individuals with posterior choroidal melanomas up to 3 mm in height underwent verteporfin-based PDT followed by immediate TTT. Further combined laser therapy was performed if a poor response was noted at 12 weeks or beyond...
February 28, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38429783/uveal-melanoma-in-the-iranian-population-two-decades-of-patient-management-in-a-tertiary-eye-center
#16
JOURNAL ARTICLE
Hamid Riazi-Esfahani, Abdulrahim Amini, Babak Masoomian, Mehdi Yaseri, Siamak Sabour, Ali Rashidinia, Mojtaba Arjmand, Seyed Mohsen Rafizadeh, Mohammadkarim Johari, Elias Khalili Pour, Fariba Ghassemi
BACKGROUND: To assess the characteristics and outcomes of uveal melanoma management at a tertiary center in the Middle East. METHODS: A study on 164 patients with uveal melanoma was conducted by reviewing the available medical records, ultrasound, and pathology report results. Age at diagnosis, tumor location and size, treatment mode, visual outcome, metastasis, mortality, and survival were studied. RESULTS: The mean age of patients was 52...
March 1, 2024: International Journal of Retina and Vitreous
https://read.qxmd.com/read/38420891/high-risk-histopathologic-features-in-local-advanced-conjunctival-melanoma
#17
JOURNAL ARTICLE
Tianyu Zhu, Chunyan Zong, Yongyun Li, Shichong Jia, Hanhan Shi, Hao Tian, Yamin Rao, Xiao Zhang, Shengfang Ge, Xianqun Fan, Yimin Li, Renbing Jia, Shiqiong Xu
PURPOSE: To identify high-risk histopathologic and molecular features of local recurrence, nodal metastasis, distant metastasis (DM) and disease-specific death (DSD) in conjunctival melanoma (CoM). METHODS: Ninety patients with pathologically diagnosed CoM between 2008 and 2023 were enrolled. Immunohistochemistry staining of BRAFV600E , NRASQ61R , CD117, PD-1 and PD-L1 was performed in 65 and 45 patients, respectively. Cox regression and Kaplan-Meier survival analysis were conducted to identify risk factors for local recurrence, nodal metastasis, DM and DSD...
February 29, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38418655/assessment-of-social-vulnerabilities-of-care-and-prognosis-in-adult-ocular-melanomas-in-the-us
#18
JOURNAL ARTICLE
Joshua A Mensah, David J Fei-Zhang, Jennifer L Rossen, Bahram Rahmani, David J Bentrem, Joshua D Stein, Dustin D French
BACKGROUND: Prior works have studied the impact of social determinants on various cancers but there is limited analysis on eye-orbit cancers. Current literature tends to focus on socioeconomic status and race, with sparse analysis of interdisciplinary contributions. We examined social determinants as measured by the Centers for Disease Control and Prevention (CDC) Social Vulnerability Index (SVI), quantifying eye and orbit melanoma disparities across the United States. METHODS: A retrospective review of 15,157 patients diagnosed with eye-orbit cancers in the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2017 was performed, extracting 6139 ocular melanomas...
February 28, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38417788/an-optimized-3t-mri-scan-protocol-to-assess-iris-melanoma-with-subsequent-histopathological-verification-a-prospective-study
#19
JOURNAL ARTICLE
Joevy Z Lim, Akilesh Gokul, Stuti L Misra, Xingzheng Pan, Amanda Charlton, Charles Nj McGhee
INTRODUCTION: Magnetic resonance imaging (MRI) has demonstrated high levels of tissue contrast, accuracy and reproducibility in evaluating posterior uveal melanoma. Owing to smaller size, the role of MRI in detecting and characterising iris melanoma has not yet been explored. AIMS: To develop a protocol to image iris melanoma and describe the MRI characteristics of histopathological-confirmed iris melanoma. MATERIALS AND METHODS: An optimised MRI protocol, using a 3T MRI scanner and a 32-channel head coil, was developed to image iris tumours...
February 26, 2024: Asia-Pacific Journal of Ophthalmology
https://read.qxmd.com/read/38413000/-medicamentous-therapy-of-malignant-eyelid-tumors
#20
JOURNAL ARTICLE
Daniel Walsch, Olga Furashova, Steffen Emmert, Vinodh Kakkassery
INTRODUCTION:  Although surgical therapy is often the first-line treatment for malignant eyelid tumors, pharmacological treatment approaches can also be included and pursued in the treatment plan. METHODS: Narrative review with a selective literature search on PubMed and Google Scholar. RESULTS:  Various pharmacological therapeutic principles are currently available. One option is the local application of agents within the tumor area...
February 27, 2024: Klinische Monatsblätter Für Augenheilkunde
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