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https://www.readbyqxmd.com/read/29906705/degradation-of-daxx-by-adenovirus-type-12-e1b-55k-circumvents-chemoresistance-of-ovarian-cancer-to-cisplatin
#1
Qiang Li, Junnai Wang, Daiqing Liao, Jihui Ai, Lei Jin, Qinglei Gao
Adenovirus E1B 55-kilodalton (E1B-55K) mediated DAXX degradation represents a potential mechanism by which E1B-55K sensitizes cancer cells to chemotherapy. Here we report the effects of E1B-55K-mediated DAXX degradation in chemoresistant ovarian cancer cells on response to chemotherapy. Cells with E1B-55K expression were more sensitive to cisplatin than cells without E1B-55K expression. In vivo C13* xenograft studies showed that the combination of cisplatin and E1B-55K was markedly more effective to slow tumor growth and to confer prolonged survival of tumor-bearing mice than either cisplatin or E1B-55K alone...
June 12, 2018: Virology
https://www.readbyqxmd.com/read/29904979/platinum-sensitivity-of-ovarian-cancer-cells-does-not-influence-their-ability-to-induce-m2-type-macrophage-polarization
#2
Agata Mlynska, Egle Povilaityte, Inga Zemleckaite, Karolina Zilionyte, Marius Strioga, Jan Krasko, Neringa Dobrovolskiene, Mei-Wen Peng, Birute Intaite, Vita Pasukoniene
PROBLEM: Development of platinum resistance in ovarian cancer is mediated by both cancer cells and tumor microenvironment. Activation of epithelial-mesenchymal transition program in cancer cells may lead to enrichment for resistant clones. These processes can be affected by tumor-associated macrophages, a highly plastic population of cells that participate in tumor progression and response to treatment by shaping the microenvironment. We aimed to study how platinum resistance influences the crosstalk between macrophages and ovarian cancer cells...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29904943/fgf9-induced-ovarian-cancer-cell-invasion-involves-vegf-a-vegfr2-augmentation-by-virtue-of-ets1-upregulation-and-metabolic-reprogramming
#3
Rahul Bhattacharya, Susri Ray Chaudhuri, Sib S Roy
Ovarian cancer (OC) renders its lethality to enhanced metastasis and late detection. A plethora of growth factors including Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) stimulated signaling pathways regulate the invasive/metastatic behavior of ovarian tumors contributing to its aggressiveness. Autocrine VEGF-functioning by virtue of upregulated VEGFR2 contributes to the invasiveness of OC cells by modulating the MMPs. Studies have highlighted the interaction between FGF and VEGF signaling pathways during angiogenesis...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904939/the-lncrna-tp73-as1-promotes-ovarian-cancer-cell-proliferation-and-metastasis-via-modulation-of-mmp2-and-mmp9
#4
Xiaoqian Wang, Bing Yang, Yuanping She, Yuan Ye
Ovarian cancer is one of the most common gynecologic malignancy with poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators in cancer development. The current study investigated the role of lncRNA P73 antisense RNA 1T (TP73-AS1) in ovarian cancer. Quantitative real-time polymerase chain reaction determined the expression levels of TP-73AS1, matrix metallopeptidases (MMPs) messenger RNA. Cell proliferative ability, cell invasion, and migration were CCK-8 and colony formation, and transwell invasion and migration assays, respectively...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904936/tpx2-gene-silencing-inhibits-cell-proliferation-and-promotes-apoptosis-through-negative-regulation-of-akt-signaling-pathway-in-ovarian-cancer
#5
Yuan Tian, Lian-Lian Liu, Dong-Mei Guo, Yan Wang, Wen-Hui Zha, Yang Li, Fu-Ju Wu
Ovarian cancer (OC) is the leading cause of death from gynecological malignancy. Accumulated studies have revealed that targeting protein for Xklp2 (TPX2) was tightly associated with the development and progression of OC. The present study further determined a novel mechanism of TPX2 in OC via the AKT signaling pathway. The differentially expressed genes were screened in GEO database for gene expression microarray of OC. Bioinformatics was used to analyze the key differentially expressed genes in OC. We prepared CD133/1+ OC stem cells...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29901199/fibroblast-growth-factor-18-promotes-the-growth-migration-and-invasion-of-mda%C3%A2-mb%C3%A2-231-cells
#6
Ziyi Yu, Longquan Lou, Yi Zhao
Fibroblast growth factor 18 (FGF18) increases cell motility and invasion in colon tumors, and is linked with ovarian and lung tumors. Furthermore, the increased expression of FGF18 mRNA and protein has been associated with poor overall survival in cancer patients. However, its function has not been investigated in breast cancer. In the present study, we demonstrated that FGF18 promoted cell growth and metastasis in vitro and stimulated tumor growth in xenograft models in vivo. FGF18 mediated the proliferation of MDA‑MB‑231 cells via the ERK/c‑Myc signaling pathway and induced epithelial‑to‑mesenchymal transition (EMT) factors to promote cancer migration and invasion...
June 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901183/a-novel-method-to-detect-the-mexican-founder-mutation-brca1-ex9%C3%A2-12del-associated-with-breast-and-ovarian-cancer-using-quantitative-polymerase-chain-reaction-and-taqman%C3%A2-probes
#7
Denisse Aideé Martínez-Treviño, Rafael Baltazar Reyes León-Cachón, Cynthia Villarreal-Garza, Dione Aguilar Y Méndez, Elisa Aguilar-Martínez, Hugo Alberto Barrera-Saldaña
In 2015, according to the National Institute of Statistics and Geography (INEGI), malignant breast tumors were the first cause of cancer fatality in women (6,273 fatalities) in Mexico, whereas 2,793 fatalities in women were due to ovarian cancer. A total of 5‑10% of breast cancer and 10‑15% of ovarian cancer cases are caused by a hereditary breast‑ovarian cancer syndrome, with mutations predominantly identified in the BRCA1 and BRCA2 genes. Recently, the Mexican founder mutation BRCA1 ex9‑12del was identified (deletion of exons 9‑12 with recombination between introns 8‑12)...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901108/blocking-the-nav1-5-channel-using-eicosapentaenoic-acid-reduces-migration-and-proliferation-of-ovarian-cancer-cells
#8
Junxiu Liu, Dawei Liu, Jasmine J Liu, Chang Zhao, Shuzhong Yao, Liang Hong
Activity of the voltage-gated Nav1.5 sodium channel has been reported to be involved in cell proliferation, cancer invasion and gene expression. In addition, eicosapentaenoic acid (EPA) has recently been suggested to inhibit ovarian cancer cell growth and suppress tumor metastasis. The present study aimed to explore the association between EPA, the Nav1.5 sodium channel and ovarian cancer cells. Using patch-clamp technique and RNA interference approaches, sodium currents were recorded in epithelial ovarian cancer cells, and it was confirmed that the Nav1...
June 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29900705/automated-classification-of-multiphoton-microscopy-images-of-ovarian-tissue-using-deep-learning
#9
Mikko J Huttunen, Abdurahman Hassan, Curtis W McCloskey, Sijyl Fasih, Jeremy Upham, Barbara C Vanderhyden, Robert W Boyd, Sangeeta Murugkar
Histopathological image analysis of stained tissue slides is routinely used in tumor detection and classification. However, diagnosis requires a highly trained pathologist and can thus be time-consuming, labor-intensive, and potentially risk bias. Here, we demonstrate a potential complementary approach for diagnosis. We show that multiphoton microscopy images from unstained, reproductive tissues can be robustly classified using deep learning techniques. We fine-train four pretrained convolutional neural networks using over 200 murine tissue images based on combined second-harmonic generation and two-photon excitation fluorescence contrast, to classify the tissues either as healthy or associated with high-grade serous carcinoma with over 95% sensitivity and 97% specificity...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29900704/polarization-resolved-second-harmonic-generation-imaging-of-human-ovarian-cancer
#10
Kirby R Campbell, Rajeev Chaudhary, Julia M Handel, Manish S Patankar, Paul J Campagnola
Remodeling of the extracellular matrix in human ovarian cancer can be manifested in increased collagen concentration, changes in alignment within fibrils/fibers and/or up-regulation of different collagen isoforms. We used pixel-based second harmonic generation (SHG) polarization microscopy analyses to probe these molecular changes in human ovarian tissues [normal stroma, benign tumors, and high-grade serous (HGS) tumors] by: (i) determination of the α-helical pitch angle via the single-axis molecular model, (ii) collagen alignment within fibrils via SHG anisotropy, and (iii) chirality via SHG circular dichroism (SHG-CD)...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29899872/hitting-two-oncogenic-machineries-in-cancer-cells-cooperative-effects-of-the-multi-kinase-inhibitor-ponatinib-and-the-bet-bromodomain-blockers-jq1-or-dbet1-on-human-carcinoma-cells
#11
Karin Bauer, Daniela Berger, Christoph C Zielinski, Peter Valent, Thomas W Grunt
In recent years, numerous new targeted drugs, including multi-kinase inhibitors and epigenetic modulators have been developed for cancer treatment. Ponatinib blocks a variety of tyrosine kinases including ABL and fibroblast growth factor receptor (FGFR), and the BET bromodomain (BRD) antagonists JQ1 and dBET1 impede MYC oncogene expression. Both drugs have demonstrated substantial anti-cancer efficacy against several hematological malignancies. Solid tumors, on the other hand, although frequently driven by FGFR and/or MYC, are often unresponsive to these drugs...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29897425/integrated-multi-omic-predictors-for-ovarian-cancer-survival
#12
A Fu, H R Chang, Z F Zhang
Increasingly affordable high-throughput molecular profiling technologies have made feasible the measurement of omics-wide interindividual variations for the purposes of predicting cancer prognosis. While multiple types of genetic, epigenetic, and expression changes have been implicated in ovarian cancer, existing prognostic biomarker strategies are constrained to analyzing single classes of molecular variations. The extra predictive power afforded by the integration of multiple omics types remains largely unexplored...
April 20, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29896986/hoxd-as1-exerts-oncogenic-functions-and-promotes-chemoresistance-in-cisplatin-resistant-cervical-cancer-cells
#13
Wenjie Hou, Min Mao, Zongji Shen, Youguo Chen, Chi Chi
Long non-coding RNAs are generally regarded as important regulators in various human diseases. As a lncRNA, HOXD-AS1 has been found to be a tumor promoter in ovarian cancer, glioma and lung cancer. However, the specific effects of HOXD-AS1 on the chemoresistance of cervical cancer cells are still not fully explored. Firstly, the level of HOXD-AS1 was tested in non-malignant tissues and CC tissues as well as in CC cells and cisplatin-resistant CC cells. As a result, HOXD-AS1 was overexpressed in CC tissues and cisplatin-resistant CC cells...
June 13, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29896229/long-non-coding-rna-gas5-inhibits-ovarian-cancer-cell-proliferation-via-the-control-of-microrna-21-and-spry2-expression
#14
Nana Ma, Shaoru Li, Quanhua Zhang, Hongmei Wang, Haixia Qin, Shijin Wang
In recent decades, numerous long non-coding (lnc)RNAs, including growth arrest-specific transcript 5 (GAS5), have been demonstrated to exert promoting or suppressive effects in human cancers. Decreased expression of the lncRNA GAS5 was reported to promote cell proliferation, migration and invasion and indicate poor prognosis in ovarian cancer. However, the exact underlying molecular mechanism through which GAS5 is involved in ovarian cancer growth remains unknown. The present study aimed to investigate the regulatory mechanism of GAS5 in ovarian cancer cell proliferation...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895933/molecular-profiles-and-tumor-mutational-burden-analysis-in-chinese-patients-with-gynecologic-cancers
#15
Min Wang, Wensheng Fan, Mingxia Ye, Chen Tian, Lili Zhao, Jianfei Wang, Wenbo Han, Wen Yang, Chenglei Gu, Mingxia Li, Zhe Zhang, Yongjun Wang, Henghui Zhang, Yuanguang Meng
The goal of this work was to investigate the tumor mutational burden (TMB) in Chinese patients with gynecologic cancer. In total, 117 patients with gynecologic cancers were included in this study. Both tumor DNA and paired blood cell genomic DNA were isolated from formalin-fixed paraffin-embedded (FFPE) specimens and blood samples, and next-generation sequencing was performed to identify somatic mutations. TP53, PTEN, ARID1A, and PIK3CA alterations were significantly different in various types of gynecologic cancers (p = 0...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29894693/selective-loss-of-parg-restores-parylation-and-counteracts-parp-inhibitor-mediated-synthetic-lethality
#16
Ewa Gogola, Alexandra A Duarte, Julian R de Ruiter, Wouter W Wiegant, Jonas A Schmid, Roebi de Bruijn, Dominic I James, Sergi Guerrero Llobet, Daniel J Vis, Stefano Annunziato, Bram van den Broek, Marco Barazas, Ariena Kersbergen, Marieke van de Ven, Madalena Tarsounas, Donald J Ogilvie, Marcel van Vugt, Lodewyk F A Wessels, Jirina Bartkova, Irina Gromova, Miguel Andújar-Sánchez, Jiri Bartek, Massimo Lopes, Haico van Attikum, Piet Borst, Jos Jonkers, Sven Rottenberg
Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, drug resistance is a clinical hurdle, and we poorly understand how cancer cells escape the deadly effects of PARPi without restoring the HR pathway. By combining genetic screens with multi-omics analysis of matched PARPi-sensitive and -resistant Brca2-mutated mouse mammary tumors, we identified loss of PAR glycohydrolase (PARG) as a major resistance mechanism...
June 11, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29894468/role-of-hydroxysteroid-dehydrogenase-like-2-hsdl2-in-human-ovarian-cancer
#17
Qing Sun, Yilin Zhang, Juanjuan Su, Tiechen Li, Yuxin Jiang
BACKGROUND Ovarian cancer is a common type of malignant neoplasm. Its prognosis is poor because the disease is not well understood. Abnormal lipometabolism in peroxisomes is involved in tumor progression and hydroxysteroid dehydrogenase-like 2 (HSDL2), localized in peroxisomes, might be a regulatory factor in lipometabolism. However, the role of HSDL2 in ovarian cancer progression remains unknown. MATERIAL AND METHODS HSDL2 expression was detected by qPCR and immunohistochemistry in ovarian tumor samples and qPCR in human ovarian cancer cell lines...
June 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29893319/the-value-of-serum-survivin-level-in-early-diagnosis-of-cancer
#18
Meral Gunaldi, Nilgun Isiksacan, Hakan Kocoglu, Yildiz Okuturlar, Omur Gunaldi, Turkan Ozturk Topcu, Mehmet Karabulut
Objective: Survivin is one of the apoptosis inhibitor proteins, and it plays a key role in tumor angiogenesis and cancer progression. This study was conducted to investigate the serum level of survivin to determine its diagnostic value in cancer patients. Materials and Methods: Blood samples were taken from cancer patients (n = 67) prior to surgery or chemo/radiotherapy and age-matched healthy volunteers (n = 23). The serum levels of survivin were analyzed by enzyme-linked immunosorbent assays...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29893277/stereotactic-body-radiation-therapy-for-oligometastatic-ovarian-cancer-a-step-toward-a-drug-holiday
#19
Roberta Lazzari, Sara Ronchi, Sara Gandini, Alessia Surgo, Stefania Volpe, Gaia Piperno, Stefania Comi, Floriana Pansini, Cristiana Fodor, Roberto Orecchia, Federica Tomao, Gabriella Parma, Nicoletta Colombo, Barbara Alicja Jereczek-Fossa
PURPOSE: To evaluate stereotactic body radiation therapy (SBRT) for metachronous oligometastatic ovarian cancer patients in terms of local control, delay of systemic treatment, survival outcomes, and toxicity. METHODS AND MATERIALS: Retrospective data collection from a single institution was performed. The inclusion criteria were as follows: (1) oligorecurrent or oligoprogressive disease in ovarian cancer patients during or after systemic therapy; (2) surgery or other local therapies not feasible; and (3) relative contraindication to systemic therapy for reasons such as unavailability of additional chemotherapy lines or refusal of the patient...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29892687/clonal-lineage-of-high-grade-serous-ovarian-cancer-in-a-patient-with-neurofibromatosis-type-1
#20
Eric J Norris, Wendell D Jones, Marius D Surleac, Andrei J Petrescu, Darla Destephanis, Qing Zhang, Issam Hamadeh, Jeffrey S Kneisl, Chad A Livasy, Ram N Ganapathi, David L Tait, Mahrukh K Ganapathi
Neurofibromatosis type 1 (NF1) is caused by mutations in the NF1 gene encoding neurofibromin, which negatively regulates Ras signaling. NF1 patients have an increased risk of developing early onset breast cancer, however, the association between NF1 and high grade serous ovarian cancer (HGSOC) is unclear. Since most NF1-related tumors exhibit early biallelic inactivation of NF1 , we evaluated the evolution of genetic alterations in HGSOC in an NF1 patient. Somatic variation analysis of whole exome sequencing of tumor samples from both ovaries and a peritoneal metastasis showed a clonal lineage originating from an ancestral clone within the left adnexa, which exhibited copy number (CN) loss of heterozygosity (LOH) in the region of chromosome 17 containing TP53, NF1 , and BRC A1 and mutation of the other TP53 allele...
February 2018: Gynecologic Oncology Reports
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