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https://www.readbyqxmd.com/read/29340409/dynamics-of-3d-carcinoma-cell-invasion-into-aligned-collagen
#1
Arja Ray, Rachel K Morford, Nima Ghaderi, David J Odde, Paolo P Provenzano
Carcinoma cells frequently expand and invade from a confined lesion, or multicellular clusters, into and through the stroma on the path to metastasis, often with an efficiency dictated by the architecture and composition of the microenvironment. Specifically, in desmoplastic carcinomas such as those of the breast, aligned collagen tracks provide contact guidance cues for directed cancer cell invasion. Yet, the evolving dynamics of this process of invasion remains poorly understood, in part due to difficulties in continuously capturing both spatial and temporal heterogeneity and progression to invasion in experimental systems...
January 17, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29340287/fully-automated-detection-of-breast-cancer-in-screening-mri-using-convolutional-neural-networks
#2
Mehmet Ufuk Dalmış, Suzan Vreemann, Thijs Kooi, Ritse M Mann, Nico Karssemeijer, Albert Gubern-Mérida
Current computer-aided detection (CADe) systems for contrast-enhanced breast MRI rely on both spatial information obtained from the early-phase and temporal information obtained from the late-phase of the contrast enhancement. However, late-phase information might not be available in a screening setting, such as in abbreviated MRI protocols, where acquisition is limited to early-phase scans. We used deep learning to develop a CADe system that exploits the spatial information obtained from the early-phase scans...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29339079/diagnostic-usefulness-of-combination-of-diffusion-weighted-imaging-and-t2wi-including-apparent-diffusion-coefficient-in-breast-lesions-assessment-of-histologic-grade
#3
Keum Won Kim, Cherie M Kuzmiak, Young Joong Kim, Jae Young Seo, Hae Kyoung Jung, Mu-Sik Lee
PURPOSE: This study aimed to compare the diagnostic values of a combination of diffusion-weighted imaging and T2-weighted imaging (DWI-T2WI) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and to evaluate the correlation of DWI with the histologic grade in breast cancer. MATERIALS AND METHODS: This study evaluated a total of 169 breast lesions from 136 patients who underwent both DCE-MRI and DWI (b value, 1000s/mm2). Morphologic and kinetic analyses for DCE-MRI were classified according to the Breast Imaging-Reporting and Data System...
January 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29338316/retroareolar-masses-and-intraductal-abnormalities-detected-on-screening-ultrasound-can-biopsy-be-avoided
#4
Yang Guo, Madhavi Raghu, Melissa Durand, Regina Hooley
OBJECTIVE: To investigate the malignancy rate of retroareolar masses and intraductal abnormalities discovered in asymptomatic women during screening whole breast ultrasound (US-S) and determine if biopsy can be avoided. METHODS: This is a HIPAA compliant retrospective study. Our radiology electronic medical records were searched for the phrases "retroareolar mass" or "intraductal mass" combined with "screening whole breast ultrasound" performed between 10/1/2009 to 5/30/2015...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29337140/characteristics-and-prognostic-factors-for-patients-with-her2-overexpressing-breast-cancer-and-brain-metastases-in-the-era-of-her2-targeted-therapy-an-argument-for-earlier-detection
#5
Aki Morikawa, Rui Wang, Sujata Patil, Adi Diab, Jonathan Yang, Clifford A Hudis, Heather L McArthur, Kathryn Beal, Andrew D Seidman
BACKGROUND: Although brain metastases (BM) are associated with poor prognosis, patients with human epidermal growth factor receptor 2 (HER2) overexpressing (HER2+) breast cancer (BC) with BM who are treated with anti-HER2 therapy have a relatively longer survival after BM diagnosis compared with other subtypes and HER2+ patients previously untreated with anti-HER2 therapy. It is unclear if previously reported prognostic factors are applicable to patients with HER2+ BC in the era of HER2-targeted therapy...
December 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29333831/-mammary-hemangioma-in-an-infant-with-apparent-mastitis-case-report
#6
Cristina Rodríguez Jiménez, Concepción Míguez Navarro, Minia Campos Domínguez, Carmen Garrido Colino
Mammary pathology is infrequent during childhood. It is rare the probability of finding a breast mass in an infant. The most frequent possible diagnoses at this age are breast abscess, mastitis, breast engorgement due to maternal hormonal stimulation and hemangioma. Reaching the proper diagnosis is essential in order to apply a suitable treatment and avoid the potential disease complications. We present the case of a female infant having a mass in the right breast from birth. Initially the entity was treated as mastitis...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333462/assessment-of-ultrasound-radio-guided-occult-lesion-localization-in-non-palpable-breast-lesions
#7
Seyed Ali Alamdaran, Donia Farokh, Ayda Sharifi Haddad, Navid Daghighi, Elaheh Modoodi, Ramin Sadeghi, Mohammad Naser Forghani, Asieh Sadat Fattahi
Objectives: Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasound- and radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333116/is-there-a-role-for-contrast-enhanced-ultrasound-in-the-detection-and-biopsy-of-mri-only-visible-breast-lesions
#8
Aki Nykänen, Otso Arponen, Anna Sutela, Ritva Vanninen, Mazen Sudah
Background: This study aimed to evaluate the feasibility of contrast-enhanced ultrasound (CEUS) and CEUS-guided interventions in the diagnostics of MRI visible targeted US occult breast lesions. Patients and methods: This retrospective study examined 10 females with 10 occult, MRI only detected breast lesions between July 2014 and April 2017. Targeted second look US followed by CEUS with 2.4 ml of SonoVue® were performed for all of the lesions. After positive CEUS localization the same dose was repeated for confirmation and CEUS-guided interventions were performed...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29333006/rational-use-of-imaging-to-stage-breast-cancer-evidences-for-a-selective-approach
#9
S G D Gangadaran
Introduction: Staging investigations at diagnosis are customary to accurately assign a clinical stage before therapy. The practice of routine imaging in patients asymptomatic for metastasis is not recommended but widely adopted. This study was done to reexamine the basis behind guideline recommendations and to identify the factors predictive of asymptomatic metastasis. Methods: Oncology records of 200 breast cancer patients in clinical Stages I-III at diagnosis were prospectively reviewed...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332357/management-of-b3-lesions-of-the-breast-implementations-of-current-recommendations-in-clinical-practice
#10
Konstantinos Stergios, Ashraf Patel, Vasilios Pergialiotis
PURPOSE: Stereotactic needle breast biopsy and vacuum assisted breast biopsy have replaced wide local excision in the last decades. B3 lesions of the breast represent a particular subgroup which is difficult to manage. The purpose of the present study was to present our experience with this specific type of lesions and to examine the conformity of Princess Margaret Hospital with current recommendations. METHODS: We retrospectively searched for patients that attended the Breast Clinic of Princess Alexandra Hospital during the period 2012-2015, and were diagnosed with B3 lesions during stereotactic needle core biopsy...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332078/magnetic-resonance-guided-high-intensity-focused-ultrasound-for-treating-movement-disorders
#11
Young Goo Kim, Eun Jung Kweon, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
Transcranial magnetic resonance-guided focused ultrasound (MRgFUS) surgery has recently gained favor as a novel, noninvasive alternative to conventional neurosurgery. In contrast to traditional ablative interventions, transcranial MRgFUS surgery is entirely imaging-guided and uses continuous temperature measurements at the target and surrounding tissue taken in real-time. Unlike Gamma Knife radiosurgery, MRgFUS surgery can make a lesion immediately and does not use ionizing radiation. Moreover, since no metallic device is implanted, MR imaging-based diagnosis is not restricted throughout life...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29330631/apparent-diffusion-coefficient-mapping-using-diffusion-weighted-mri-impact-of-background-parenchymal-enhancement-amount-of-fibroglandular-tissue-and-menopausal-status-on-breast-cancer-diagnosis
#12
Joao V Horvat, Manuela Durando, Soledad Milans, Sujata Patil, Jessica Massler, Girard Gibbons, Dilip Giri, Katja Pinker, Elizabeth A Morris, Sunitha B Thakur
OBJECTIVES: To investigate the impact of background parenchymal enhancement (BPE), amount of fibroglandular tissue (FGT) and menopausal status on apparent diffusion coefficient (ADC) values in differentiation between malignant and benign lesions. METHODS: In this HIPAA-compliant study, mean ADC values of 218 malignant and 130 benign lesions from 288 patients were retrospectively evaluated. The differences in mean ADC values between benign and malignant lesions were calculated within groups stratified by BPE level (high/low), amount of FGT (dense/non-dense) and menopausal status (premenopausal/postmenopausal)...
January 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29325854/considerations-in-the-diagnosis-of-oral-hairy-leukoplakia-an-institutional-experience
#13
Andres Flores-Hidalgo, Si On Lim, Alice E Curran, Ricardo J Padilla, Valerie Murrah
OBJECTIVE: We report here the 10-year experience with oral hairy leukoplakia (OHL) at the Division of Oral and Maxillofacial Pathology at the University of North Carolina at Chapel Hill, NC, USA. STUDY DESIGN: All the associated hematoxylin and eosin and Epstein-Barr virus encoding region in situ hybridization slides of OHL cases between January 1, 2008, and February 1, 2017, were retrieved and reviewed. Collected demographic characteristics, clinical presentation, medical and social histories were reviewed and reported...
November 15, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29323551/gamma-imaging-guided-minimally-invasive-breast-biopsy-initial-clinical-experience
#14
Rachel F Brem, Anita K Mehta, Jocelyn A Rapelyea, Esma A Akin, Adriana M Bazoberry, Christel D Velasco
OBJECTIVE: The purpose of this study was to evaluate our initial experience with gamma imaging-guided vacuum-assisted breast biopsy in women with abnormal findings. MATERIALS AND METHODS: A retrospective review of patients undergoing breast-specific gamma imaging (BSGI), also known as molecular breast imaging (MBI), between April 2011 and October 2015 found 117 nonpalpable mammographically and sonographically occult lesions for which gamma imaging-guided biopsies were recommended...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29322796/pitfalls-of-contrast-enhanced-ultrasound-ceus-in-determination-of-breast-tumor-biological-dignity
#15
V Lehotska, K Rauova, L Vanovcanova
The aim of this prospective study was to identify characteristics of breast lesions on contrast enhanced ultrasound (CEUS) that can be a source of diagnostic ambiguity and cause under- or overestimation of examined breast lesions. 215 women (range 23-76 y., mean age 53.16 y) with 215 breast lesions were examined by B-mode ultrasound, followed by CEUS and core biopsy. CEUS parameters: degree of opacification, character of washout and preliminary CEUS result (suspicious, non-suspicious, uncertain) were subsequently correlated with histopathological outcomes...
2018: Neoplasma
https://www.readbyqxmd.com/read/29322559/cest-dixon-for-human-breast-lesion-characterization-at-3-t-a-preliminary-study
#16
Shu Zhang, Stephen Seiler, Xinzeng Wang, Ananth J Madhuranthakam, Jochen Keupp, Emily E Knippa, Robert E Lenkinski, Elena Vinogradov
PURPOSE: Chemical exchange saturation transfer (CEST) MRI for breast lesion characterization is promising. However, artifacts are prone to develop in breast CEST imaging as a result of strong lipid signals. The aims of the study are (i) to develop and validate the CEST-Dixon imaging sequence for simultaneous water-fat separation and B0 mapping; and (ii) use the CEST-Dixon method to characterize suspicious lesions in patients undergoing percutaneous biopsy. METHODS: The gradient-echo multi-echo Dixon acquisition is used to create fat-free CEST and B0 maps...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29322120/juvenile-papillomatosis-of-the-breast-in-a-pre-pubertal-girl-an-uncommon-diagnosis
#17
Mehmet Tolga Kafadar, Zeynep Anadolulu, Ali İhsan Anadolulu, Emine Zeynep Tarini
Juvenile papillomatosis of the breast represents a rare benign proliferative disorder that affects women younger than thirty years of age. Although it is a localized lesion, it does not have well-demarcated margins. These patients tend to have a strong family history for cancer. As it has similar clinical presentation with that of a fibroadenoma, it usually receives the diagnosis of the latter in the preoperative period. Nonetheless, it has distinct microscopic features such as ductal papillomatosis and cysts that are helpful in the diagnosis...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29322118/mr-imaging-features-of-tubular-carcinoma-preliminary-experience-in-twelve-masses
#18
Ravza Yılmaz, Zuhal Bayramoğlu, Selman Emirikçi, Semen Önder, Artur Salmaslıoğlu, Memduh Dursun, Gülden Acunaş, Vahit Özmen
Objective: We retrospectively analyzed the magnetic resonance (MR) imaging features and diffusion-weighted imaging findings of the 12 masses of 10 patients with tubular carcinoma (TC), including mammography and sonography findings. Materials and Methods: Mammographic, sonographic and magnetic resonance imaging features in 12 histopathologically confirmed masses diagnosed as TC of the breast within 10 patients were evaluated. Morphologic characteristics, enhancement features, apparent diffusion coefficient (ADC) values were reviewed...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29322116/efficiency-of-imaging-modalities-in-male-breast-disease-can-ultrasound-give-additional-information-for-assessment-of-gynecomastia-evolution
#19
Özgür Sarıca, A Nedim Kahraman, Enis Öztürk, Memik Teke
Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia. Materials and Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29320327/atypical-sites-of-deeply-infiltrative-endometriosis-clinical-characteristics-and-imaging-findings
#20
Luciana P Chamié, Duarte Miguel Ferreira Rodrigues Ribeiro, Dario A Tiferes, Augusto Cesar de Macedo Neto, Paulo C Serafini
Endometriosis is defined as the presence of endometrial tissue that is located outside the uterine cavity and associated with fibrosis and inflammatory reaction. It is a polymorphic and multifocal disease with no known cure or preventive mechanisms. Patients may be asymptomatic or may experience chronic pelvic pain, dysmenorrhea, dyspareunia, or infertility. The pelvic cavity is the most common location for endometriotic implants, which usually affect the retrocervical space, ovaries, vagina, rectosigmoid colon, bladder dome, and round ligaments...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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