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ventrolateral preoptic nucleus

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https://www.readbyqxmd.com/read/27912885/tetrandrine-an-alkaloid-from-s-tetrandra-exhibits-anti-hypertensive-and-sleep-enhancing-effects-in-shr-via-different-mechanisms
#1
Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang
BACKGROUND: Sleep disorders have been found to be associated with hypertension in both cross-sectional and longitudinal epidemiological studies. Tetrandrine, a major component of Stephania tetrandra, is well known as an antihypertensive agent. The anti-hypertension mechanism mainly relies on its L-type calcium channel blocking property. In the previous study, tetrandrine revealed both anti-hypertension and hypnotic effects in spontaneously hypertensive rats (SHRs). PURPOSE: This study aims to elucidate whether the antihypertensive mechanism of tetrandrine in SHRs is relevant to its hypnotic effect...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27562857/estradiol-valerate-and-remifemin-ameliorate-ovariectomy-induced-decrease-in-a-serotonin-dorsal-raphe-preoptic-hypothalamus-pathway-in-rats
#2
Wenjuan Wang, Guangxia Cui, Biao Jin, Ke Wang, Xing Chen, Yu Sun, Lihua Qin, Wenpei Bai
Perimenopausal syndromes begin as ovarian function ceases and the most common symptoms are hot flushes. Data indicate that the projections of serotonin to hypothalamus may be involved in the mechanism of hot flushes. Therefore, the aim of this study is to investigate the potential role of the serotonin dorsal raphe-preoptic hypothalamus pathway for hot flushes in an animal model of menopause. We determined the changes in serotonin expression in the dorsal raphe (DR) and preoptic anterior hypothalamus (POAH) in ovariectomized rats...
November 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27456222/ca-2-in-the-dorsal-raphe-nucleus-promotes-wakefulness-via-endogenous-sleep-wake-regulating-pathway-in-the-rats
#3
Su-Ying Cui, Sheng-Jie Li, Xiang-Yu Cui, Xue-Qiong Zhang, Bin Yu, Yuan-Li Huang, Qing Cao, Ya-Ping Xu, Guang Yang, Hui Ding, Jin-Zhi Song, Hui Ye, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang
Serotonergic neurons in the dorsal raphe nucleus (DRN) are involved in the control of sleep-wake states. Our previous studies have indicated that calcium (Ca(2+)) modulation in the DRN plays an important role in rapid-eye-movement sleep (REMS) and non-REMS (NREMS) regulation during pentobarbital hypnosis. The present study investigated the effects of Ca(2+) in the DRN on sleep-wake regulation and the related neuronal mechanism in freely moving rats. Our results showed that microinjection of CaCl2 (25 or 50 nmol) in the DRN promoted wakefulness and suppressed NREMS including slow wave sleep and REMS in freely moving rats...
2016: Molecular Brain
https://www.readbyqxmd.com/read/27426512/chemogenetic-activation-of-melanopsin-retinal-ganglion-cells-induces-signatures-of-arousal-and-or-anxiety-in-mice
#4
Nina Milosavljevic, Jasmina Cehajic-Kapetanovic, Christopher A Procyk, Robert J Lucas
Functional imaging and psychometric assessments indicate that bright light can enhance mood, attention, and cognitive performance in humans. Indirect evidence links these events to light detection by intrinsically photosensitive melanopsin-expressing retinal ganglion cells (mRGCs) [1-9]. However, there is currently no direct demonstration that mRGCs can have such an immediate effect on mood or behavioral state in any species. We addressed this deficit by using chemogenetics to selectively activate mRGCs, simulating the excitatory effects of bright light on this cell type in dark-housed mice...
September 12, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27426511/a-novel-population-of-wake-promoting-gabaergic-neurons-in-the-ventral-lateral-hypothalamus
#5
Anne Venner, Christelle Anaclet, Rebecca Y Broadhurst, Clifford B Saper, Patrick M Fuller
The largest synaptic input to the sleep-promoting ventrolateral preoptic area (VLPO) [1] arises from the lateral hypothalamus [2], a brain area associated with arousal [3-5]. However, the neurochemical identity of the majority of these VLPO-projecting neurons within the lateral hypothalamus (LH), as well as their function in the arousal network, remains unknown. Herein we describe a population of VLPO-projecting neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neurons)...
August 22, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27393010/multiparametric-characterization-of-neuronal-subpopulations-in-the-ventrolateral-preoptic-nucleus
#6
Romain Dubourget, Aude Sangare, Hélène Geoffroy, Thierry Gallopin, Armelle Rancillac
The characterization of neuronal properties is a necessary first step toward understanding how the ventrolateral preoptic nucleus (VLPO) neuronal network regulates slow-wave sleep (SWS). Indeed, the electrophysiological heterogeneity of VLPO neurons suggests the existence of subtypes that could differently contribute in SWS induction and maintenance. The aim of the present study was to define cell classes in the VLPO using an unsupervised clustering classification method. Electrophysiological features extracted from 289 neurons recorded in whole-cell patch-clamp allowed the identification of three main classes of VLPO neurons subdivided into five distinct subpopulations (cluster 1, 2a, 2b, 3a and 3b)...
July 8, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27373591/effect-of-acute-imipramine-administration-on-the-pattern-of-forced-swim-induced-c-fos-expression-in-the-mouse-brain
#7
Satoru Yanagida, Keisuke Motomura, Ayako Ohashi, Kentaro Hiraoka, Tomofumi Miura, Shigenobu Kanba
The forced swim test (FST) has been widely used for the preclinical evaluation of antidepressant drugs. Despite considerable differences in the protocol, equivalence of the FST for rats and mice has been rarely questioned. Previous research on the FST for rats revealed that repeated administration of antidepressant drugs attenuates the c-Fos response to swim stress in the hypothalamus and limbic regions. However, few studies have made similar investigations using the FST for mice. In the present study, we explored the mouse brain through immunohistochemistry staining for c-Fos after acute administration of imipramine or saline with or without a subsequent swim session...
August 26, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27238836/serotonin-differentially-modulates-excitatory-and-inhibitory-synaptic-inputs-to-putative-sleep-promoting-neurons-of-the-ventrolateral-preoptic-nucleus
#8
Aude Sangare, Romain Dubourget, Hélène Geoffroy, Thierry Gallopin, Armelle Rancillac
The role of serotonin (5-HT) in sleep-wake regulation has been a subject of intense debate and remains incompletely understood. In the ventrolateral preoptic nucleus (VLPO), the main structure that triggers non-rapid eye movement (NREM) sleep, putative sleep-promoting (PSP) neurons were shown ex vivo to be either inhibited (Type-1) or excited (Type-2) by 5-HT application. To determine the complex action of this neurotransmitter on PSP neurons, we recorded spontaneous and miniature excitatory and inhibitory postsynaptic currents (sEPSCs, sIPSCs, mEPSCs and mIPSCs) in response to bath application of 5-HT...
October 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27083772/not-a-single-but-multiple-populations-of-gabaergic-neurons-control-sleep
#9
Pierre-Hervé Luppi, Christelle Peyron, Patrice Fort
The role of gamma-amino butyric acid (GABA) in sleep induction and maintenance is well accepted since most insomnia treatments target GABAa receptors. However, the population(s) of GABAergic neurons involved in the beneficial effect of GABA on sleep remains to be identified. This is not an easy task since GABAergic neurons are widely distributed in all brain structures. A recently growing number of populations of GABAergic neurons have been involved in sleep control. We first review here possible candidates for inducing non-rapid eye movement (NREM) sleep including the GABAergic neurons of the ventrolateral preoptic area, the parafacial zone in the brainstem, the nucleus accumbens and the cortex...
March 12, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27017507/erratum-to-the-ventrolateral-preoptic-nucleus-is-required-for-propofol-induced-inhibition-of-locus-coeruleus-neuronal-activity
#10
Yu Zhang, Tian Yu, Jie Yuan, Bu-Wei Yu
No abstract text is available yet for this article.
March 26, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/26951397/disrupted-sleep-in-narcolepsy-exploring-the-integrity-of-galanin-neurons-in-the-ventrolateral-preoptic-area
#11
Yury V Gavrilov, Brian A Ellison, Mihoko Yamamoto, Hasini Reddy, Johannes Haybaeck, Emmanuel Mignot, Christian R Baumann, Thomas E Scammell, Philipp O Valko
STUDY OBJECTIVES: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. METHODS: Postmortem examination of five narcolepsy and eight control brains. RESULTS: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544). CONCLUSIONS: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease...
May 1, 2016: Sleep
https://www.readbyqxmd.com/read/26838032/neural-control-of-blood-pressure-in-chronic-intermittent-hypoxia
#12
REVIEW
Brent Shell, Katelynn Faulk, J Thomas Cunningham
Sleep apnea (SA) is increasing in prevalence and is commonly comorbid with hypertension. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in SA, and through this paradigm, the mechanisms that underlie SA-induced hypertension are becoming clear. Cyclic hypoxic exposure during sleep chronically stimulates the carotid chemoreflexes, inducing sensory long-term facilitation, and drives sympathetic outflow from the hindbrain. The elevated sympathetic tone drives hypertension and renal sympathetic activity to the kidneys resulting in increased plasma renin activity and eventually angiotensin II (Ang II) peripherally...
March 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/26797244/basal-forebrain-cholinergic-neurons-primarily-contribute-to-inhibition-of-electroencephalogram-delta-activity-rather-than-inducing-behavioral-wakefulness-in-mice
#13
Li Chen, Dou Yin, Tian-Xiao Wang, Wei Guo, Hui Dong, Qi Xu, Yan-Jia Luo, Yoan Cherasse, Michael Lazarus, Zi-Long Qiu, Jun Lu, Wei-Min Qu, Zhi-Li Huang
The basal forebrain (BF) cholinergic neurons have long been thought to be involved in behavioral wakefulness and cortical activation. However, owing to the heterogeneity of BF neurons and poor selectivity of traditional methods, the precise role of BF cholinergic neurons in regulating the sleep-wake cycle remains unclear. We investigated the effects of cell-selective manipulation of BF cholinergic neurons on the sleep-wake behavior and electroencephalogram (EEG) power spectrum using the pharmacogenetic technique, the 'designer receptors exclusively activated by designer drugs (DREADD)' approach, and ChAT-IRES-Cre mice...
July 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26333784/suppression-of-preoptic-sleep-regulatory-neuronal-activity-during-corticotropin-releasing-factor-induced-sleep-disturbance
#14
Irma Gvilia, Natalia Suntsova, Sunil Kumar, Dennis McGinty, Ronald Szymusiak
Corticotropin releasing factor (CRF) is implicated in sleep and arousal regulation. Exogenous CRF causes sleep suppression that is associated with activation of at least two important arousal systems: pontine noradrenergic and hypothalamic orexin/hypocretin neurons. It is not known whether CRF also impacts sleep-promoting neuronal systems. We hypothesized that CRF-mediated changes in wake and sleep involve decreased activity of hypothalamic sleep-regulatory neurons localized in the preoptic area. To test this hypothesis, we examined the effects of intracerebroventricular administration of CRF on sleep-wake measures and c-Fos expression in GABAergic neurons in the median preoptic nucleus (MnPN) and ventrolateral preoptic area (VLPO) in different experimental conditions...
November 1, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26306695/the-ventrolateral-preoptic-nucleus-is-required-for-propofol-induced-inhibition-of-locus-coeruleus-neuronal-activity
#15
Yu Zhang, Tian Yu, Jie Yuan, Bu-Wei Yu
The mechanisms underlying the unconsciousness of general anesthesia are not completely understood. Accumulating evidence indicates the ventrolateral preoptic nucleus (VLPO) in the endogenous sleep circuits may contribute to loss of consciousness (LOC) induced by GABA-enhancing anesthetics. However, there are few studies that look into distinct sleep pathway in the sleep-wake system. In the neural pathway from VLPO to the locus coeruleus (LC), we compared the inhibition effect of propofol on the LC activity before and after VLPO lesion in vivo rats...
December 2015: Neurological Sciences
https://www.readbyqxmd.com/read/26156991/glucose-induces-slow-wave-sleep-by-exciting-the-sleep-promoting-neurons-in-the-ventrolateral-preoptic-nucleus-a-new-link-between-sleep-and-metabolism
#16
Christophe Varin, Armelle Rancillac, Hélène Geoffroy, Sébastien Arthaud, Patrice Fort, Thierry Gallopin
UNLABELLED: Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poorly understood. Here, we test the hypothesis that a rise in extracellular glucose concentration in the VLPO can promote sleep by increasing the activity of sleep-promoting VLPO neurons. We find that infusion of a glucose concentration into the VLPO of mice promotes SWS and increases the density of c-Fos-labeled neurons selectively in the VLPO...
July 8, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25970525/pkc-in-rat-dorsal-raphe-nucleus-plays-a-key-role-in-sleep-wake-regulation
#17
Sheng-Jie Li, Su-Ying Cui, Xue-Qiong Zhang, Bin Yu, Zhao-Fu Sheng, Yuan-Li Huang, Qing Cao, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang, Xiang-Yu Cui, Yong-He Zhang
Studies suggest a tight relationship between protein kinase C (PKC) and circadian clock. However, the role of PKC in sleep-wake regulation remains unclear. The present study was conducted to investigate the role of PKC signaling in sleep-wake regulation in the rat. Our results showed that the phosphorylation level of PKC in dorsal raphe nucleus (DRN) was decreased after 6h sleep deprivation, while no alterations were found in ventrolateral preoptic nucleus (VLPO) or locus coeruleus (LC). Microinjection of a pan-PKC inhibitor, chelerythrine chloride (CHEL, 5 or 10nmol), into DRN of freely moving rats promoted non rapid eye movement sleep (NREMS) without influences on rapid eye movement sleep (REMS)...
December 3, 2015: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/25753944/the-median-preoptic-nucleus-front-and-centre-for-the-regulation-of-body-fluid-sodium-temperature-sleep-and-cardiovascular-homeostasis
#18
REVIEW
M J McKinley, S T Yao, A Uschakov, R M McAllen, M Rundgren, D Martelli
Located in the midline anterior wall of the third cerebral ventricle (i.e. the lamina terminalis), the median preoptic nucleus (MnPO) receives a unique set of afferent neural inputs from fore-, mid- and hindbrain. These afferent connections enable it to receive neural signals related to several important aspects of homeostasis. Included in these afferent projections are (i) neural inputs from two adjacent circumventricular organs, the subfornical organ and organum vasculosum laminae terminalis, that respond to hypertonicity, circulating angiotensin II or other humoural factors, (ii) signals from cutaneous warm and cold receptors that are relayed to MnPO, respectively, via different subnuclei in the lateral parabrachial nucleus and (iii) input from the medulla associated with baroreceptor and vagal afferents...
May 2015: Acta Physiologica
https://www.readbyqxmd.com/read/25599767/hypothalamic-expression-of-oestrogen-receptor-%C3%AE-and-androgen-receptor-is-sex-age-and-region-dependent-in-mice
#19
O Brock, C De Mees, J Bakker
Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors, such as oestrogen receptor (ER)-α and androgen receptor (AR). By using immunohistochemistry, we analysed the expression level of ERα and AR throughout perinatal life [at embryonic (E) day 19 and postnatal (P) days 5, 15 and 25] and in adulthood in several hypothalamic nuclei controlling reproduction in both wild-type and aromatase knockout (ArKO) (i...
April 2015: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/25471576/%C3%AE-2-adrenergic-stimulation-of-the-ventrolateral-preoptic-nucleus-destabilizes-the-anesthetic-state
#20
Hilary S McCarren, Michael R Chalifoux, Bo Han, Jason T Moore, Qing Cheng Meng, Nina Baron-Hionis, Madineh Sedigh-Sarvestani, Diego Contreras, Sheryl G Beck, Max B Kelz
The sleep-promoting ventrolateral preoptic nucleus (VLPO) shares reciprocal inhibitory inputs with wake-active neuronal nuclei, including the locus ceruleus. Electrophysiologically, sleep-promoting neurons in the VLPO are directly depolarized by the general anesthetic isoflurane and hyperpolarized by norepinephrine, a wake-promoting neurotransmitter. However, the integration of these competing influences on the VLPO, a sleep- and anesthetic-active structure, has yet to be evaluated in either brain slices in vitro or the intact organism...
December 3, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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