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Type VI secretion

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https://www.readbyqxmd.com/read/29452951/antibacterial-weapons-targeted-destruction-in-the-microbiota
#1
REVIEW
Benoit Chassaing, Eric Cascales
The intestinal microbiota plays an important role in health, particularly in promoting intestinal metabolic capacity and in maturing the immune system. The intestinal microbiota also mediates colonization resistance against pathogenic bacteria, hence protecting the host from infections. In addition, some bacterial pathogens deliver toxins that target phylogenetically related or distinct bacterial species in order to outcompete and establish within the microbiota. The most widely distributed weapons include bacteriocins, as well as contact-dependent growth inhibition and type VI secretion systems...
February 13, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29446804/t6ss-intraspecific-competition-orchestrates-vibrio-cholerae-genotypic-diversity
#2
REVIEW
Benjamin Kostiuk, Daniel Unterweger, Daniele Provenzano, Stefan Pukatzki
Vibrio cholerae is a diverse species that inhabits a wide range of environments from copepods in brackish water to the intestines of humans. In order to remain competitive, V. cholerae uses the versatile type-VI secretion system (T6SS) to secrete anti-prokaryotic and anti-eukaryotic effectors. In addition to competing with other bacterial species, V. cholerae strains also compete with one another. Some strains are able to coexist, and are referred to as belonging to the same compatibility group. Challenged by diverse competitors in various environments, different V...
September 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/29446800/biology-of-vibrio-cholera-editorial-overview
#3
EDITORIAL
Felipe Cava
In this monographic issue, we have the pleasure to present contributions from six of the leading laboratories at the forefront of Vibrio cholerae genetics, ecology and evolution, together with a brief tribute by Diego Romero to Doctor Jaime Ferrán y Clua, a pioneering Spanish bacteriologist who developed the first vaccine against this pathogen. V. cholerae is a free-living aquatic bacterium that interacts with and infects a variety of organisms. In humans it causes cholera, the deadly diarrhoea that was responsible for millions of deaths during seven pandemics since 1817, and still thousands every year...
September 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/29437919/physiological-heterogeneity-triggers-sibling-conflict-mediated-by-the-type-vi-secretion-system-in-an-aggregative-multicellular-bacterium
#4
Vera Troselj, Anke Treuner-Lange, Lotte Søgaard-Andersen, Daniel Wall
A hallmark of social microorganisms is their ability to engage in complex and coordinated behaviors that depend on cooperative and synchronized actions among many cells. For instance, myxobacteria use an aggregation strategy to form multicellular, spore-filled fruiting bodies in response to starvation. One barrier to the synchronization process is physiological heterogeneity within clonal populations. How myxobacteria cope with these physiological differences is poorly understood. Here, we investigated the interactions between closely related but physiologically distinct Myxococcus xanthus populations...
February 6, 2018: MBio
https://www.readbyqxmd.com/read/29424333/pathogenesis-of-proteus-mirabilis-infection
#5
Chelsie E Armbruster, Harry L T Mobley, Melanie M Pearson
Proteus mirabilis , a Gram-negative rod-shaped bacterium most noted for its swarming motility and urease activity, frequently causes catheter-associated urinary tract infections (CAUTIs) that are often polymicrobial. These infections may be accompanied by urolithiasis, the development of bladder or kidney stones due to alkalinization of urine from urease-catalyzed urea hydrolysis. Adherence of the bacterium to epithelial and catheter surfaces is mediated by 17 different fimbriae, most notably MR/P fimbriae...
February 2018: EcoSal Plus
https://www.readbyqxmd.com/read/29422784/genome-wide-analysis-of-type-vi-system-clusters-and-effectors-in-burkholderia-species
#6
Thao Thi Nguyen, Hyun-Hee Lee, Inmyoung Park, Young-Su Seo
Type VI secretion system (T6SS) has been discovered in a variety of gram-negative bacteria as a versatile weapon to stimulate the killing of eukaryotic cells or prokaryotic competitors. Type VI secretion effectors (T6SEs) are well known as key virulence factors for important pathogenic bacteria. In many Burkholderia species, T6SS has evolved as the most complicated secretion pathway with distinguished types to translocate diverse T6SEs, suggesting their essential roles in this genus. Here we attempted to detect and characterize T6SSs and potential T6SEs in target genomes of plant-associated and environmental Burkholderia species based on computational analyses...
February 2018: Plant Pathology Journal
https://www.readbyqxmd.com/read/29414766/expanding-the-molecular-weaponry-of-bacterial-species
#7
Juvenal Lopez, Mario F Feldman
The type VI secretion system (T6SS) delivers toxic effectors between Gram-negative bacteria. Most antibacterial T6SS effectors are peptidoglycanases, nucleases, or lipases. In the current work, Tang et al. structurally and functionally characterize a novel family of NAD(P)+-hydrolyzing effectors (NADases), thus expanding the documented types of T6SS substrates. Bioinformatic identification of NADase family members putatively secreted by the bacteriolytic type VII secretion system (T7SS) of Gram-positive bacteria further points to NADases as a diverse and important class of effectors...
February 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29414515/towards-a-complete-structural-deciphering-of-type-vi-secretion-system
#8
REVIEW
Van Son Nguyen, Badreddine Douzi, Eric Durand, Alain Roussel, Eric Cascales, Christian Cambillau
The Type VI secretion system (T6SS) is a dynamic nanomachine present in many Gram-negative bacteria. Using a contraction mechanism similar to that of myophages, bacteriocins or anti-feeding prophages, it injects toxic effectors into both eukaryotic and prokaryotic cells. T6SS assembles three large ensembles: the trans-membrane complex (TMC), the baseplate and the tail. Recently, the tail structure has been elucidated by cryo electron microscopy (cryoEM) in extended and contracted forms. The structure of the trans-membrane complex has been deciphered using a combination of X-ray crystallography and EM...
February 1, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29405518/contractile-injection-systems-of-bacteriophages-and-related-systems
#9
REVIEW
Nicholas M I Taylor, Mark J van Raaij, Petr G Leiman
Contractile tail bacteriophages, or myobacteriophages, use a sophisticated biomolecular structure to inject their genome into the bacterial host cell. This structure consists of a contractile sheath enveloping a rigid tube that is sharpened by a spike-shaped protein complex at its tip. The spike complex forms the centerpiece of a baseplate complex that terminates the sheath and the tube. The baseplate anchors the tail to the target cell membrane with the help of fibrous proteins emanating from it and triggers contraction of the sheath...
February 5, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29394318/phylogenetic-profiling-an-untapped-resource-for-the-prediction-of-secreted-proteins-and-its-complementation-with-sequence-based-classifiers-in-bacterial-type-iii-iv-and-vi-secretion-systems
#10
Andrés Zalguizuri, Gustavo Caetano-Anollés, Viviana Claudia Lepek
In the establishment and maintenance of the interaction between pathogenic or symbiotic bacteria with a eukaryotic organism, protein substrates of specialized bacterial secretion systems called effectors play a critical role once translocated into the host cell. Proteins are also secreted to the extracellular medium by free-living bacteria or directly injected into other competing organisms to hinder or kill. In this work, we explore an approach based on the evolutionary dependence that most of the effectors maintain with their specific secretion system that analyzes the co-occurrence of any orthologous protein group and their corresponding secretion system across multiple genomes...
January 31, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29394284/the-role-of-the-type-vi-secretion-system-vgrg-gene-in-the-virulence-and-antimicrobial-resistance-of-acinetobacter-baumannii-atcc-19606
#11
Jianfeng Wang, Zhihui Zhou, Fang He, Zhi Ruan, Yan Jiang, Xiaoting Hua, Yunsong Yu
The Type VI Secretion System (T6SS) is an important virulence system that exists in many bacterial pathogens, and has emerged as a potent mediator of pathogenicity in Acinetobacter baumannii. In this study, we inactivated one of the T6SS components vgrG (valine-glycine repeat G) gene in A. baumannii ATCC 19606 and constructed a complementation strain. BEAS-2b human alveolar epithelial cells was adopted to assess bacterial adhesion, and wild female BALB/c mice were used for in vivo experiments to assess the bacterial killing ability to host...
2018: PloS One
https://www.readbyqxmd.com/read/29358237/stretching-the-arms-of-the-type-vi-secretion-sheath-protein
#12
Petr G Leiman
No abstract text is available yet for this article.
January 22, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29355700/characteristics-of-an-aeromonas-trota-strain-isolated-from-cerebrospinal-fluid
#13
Cibelle B Dallagassa, Monica Surek, Bruno S Vizzotto, Karoline C Prediger, Bárbara Moriel, Suélen Wolf, Vinícius Weiss, Leonardo M Cruz, Flávia E A Assis, Katia S Paludo, Fabiane G M Rego, Sônia M S S Farah, Geraldo Picheth, Emanuel M Souza, Fábio O Pedrosa, Leda S Chubatsu, Cyntia M T Fadel-Picheth
Aeromonas are ubiquitous in aquatic habitats. However some species can cause infections in humans, but rarely meningitis. Here we describe the isolation and characterization of an Aeromonas strain from cerebrospinal fluid of a meningitis patient. The isolate, identified as A. trota by biochemical and molecular methods, was susceptible to ampicillin but resistant to cephalothin and cefazolin. Genome sequencing revealed virulence factor genes such as type VI secretion system, aerolysin and lateral flagella. The isolate exhibited swarming motility, hemolytic activity and adhesion and cytotoxicity on HeLa cells...
January 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29350941/immotile-active-matter-activity-from-death-and-reproduction
#14
Arben Kalziqi, David Yanni, Jacob Thomas, Siu Lung Ng, Skanda Vivek, Brian K Hammer, Peter J Yunker
Unlike equilibrium atomic solids, biofilms-soft solids composed of bacterial cells-do not experience significant thermal fluctuations at the constituent level. However, living cells stochastically reproduce and die, provoking a mechanical response. We investigate the mechanical consequences of cellular death and reproduction by measuring surface-height fluctuations of biofilms containing two mutually antagonistic strains of Vibrio cholerae that kill one another on contact via the type VI secretion system. While studies of active matter typically focus on activity via constituent mobility, here, activity is mediated by reproduction and death events in otherwise immobilized cells...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29349780/protective-effect-of-bled-exposed-conditioned-media-on-cell-injury
#15
Phil-Sun Oh, Eun-Mi Kim, Minjoo Kim, In Sun Kim, Yeon-Hee Han, SeokTae Lim, Myung-Hee Sohn, Myoung-Hwan Ko, Hwan-Jeong Jeong
Previous studies have reported that 450 nm blue light emitting diode (BLED) induces apoptosis through a mitochondria-mediated pathway in cancer cells and reduces the early stage tumor growth. The present study was performed to determine the effects of BLED-irradiated cell metabolites on cell injury. Our results showed that conditioned medium (CM) from cells irradiated with low-dose BLED (LCM) inhibited apoptosis and increased cell survival. Cell protection-related proteins were identified in cell metabolites of CM and LCM using 2-DE and MALDI-TOF analysis...
January 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29346773/dual-role-for-dsba-in-attacking-and-targeted-bacterial-cells-during-type-vi-secretion-system-mediated-competition
#16
Giuseppina Mariano, Laura Monlezun, Sarah J Coulthurst
Incorporation of disulfide bonds into proteins can be critical for function or stability. In bacterial cells, the periplasmic enzyme DsbA is responsible for disulfide incorporation into many extra-cytoplasmic proteins. The type VI secretion system (T6SS) is a widely occurring nanomachine that delivers toxic effector proteins directly into rival bacterial cells, playing a key role in inter-bacterial competition. We report that two redundant DsbA proteins are required for virulence and for proper deployment of the T6SS in the opportunistic pathogen Serratia marcescens, with several T6SS components being subject to the action of DsbA in secreting cells...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346648/esrb-negatively-regulates-expression-of-the-glutamine-sythetase-glna-in-the-fish-pathogen-edwardsiella-piscicida
#17
Yunpeng Guan, Kaiyu Yin, Mian Zhou, Minjun Yang, Yuanxing Zhang, Xiaohong Liu, Qiyao Wang
Edwardsiella piscicida is a gram-negative bacterial pathogen invading a wide range of fish species. Response regulator EsrB is essential for activation of type III and type VI secretion systems (T3/T6SS). In this study, proteomes of the wild type E. piscicida EIB202 and a ΔesrB mutant strains were compared to identify the regulon components of EsrB cultured in DMEM allowing T3/T6SS expression. As a result, 19 proteins showed different expression, which were identified to be associated with T3/T6SS, related to amino acid transport and metabolism, and energy production...
January 15, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29326272/antagonism-toward-the-intestinal-microbiota-and-its-effect-on-vibrio-cholerae-virulence
#18
Wenjing Zhao, Florence Caro, William Robins, John J Mekalanos
The bacterial type VI secretion system (T6SS) is a nanomachine that delivers toxic effector proteins into target cells, killing them. In mice, we found that the Vibrio cholerae T6SS attacks members of the host commensal microbiota in vivo, facilitating the pathogen's colonization of the gut. This microbial antagonistic interaction drives measurable changes in the pathogenicity of V. cholerae through enhanced intestinal colonization, expression of bacterial virulence genes, and activation of host innate immune genes...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29322563/microfluidics-based-lc-ms-mrm-approach-for-the-relative-quantification-of-burkholderia-cenocepacia-secreted-virulence-factors
#19
Sofie Depluverez, Simon Daled, Stijn De Waele, Sören Planckaert, Jolien Schoovaerts, Dieter Deforce, Bart Devreese
Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Several virulence factors have been identified, including extracellular enzymes that are secreted by type II and type VI secretion systems. The activity of these secretion systems is modulated by quorum sensing. Apart from the classical acylhomoserine lactone quorum sensing, B. cenocepacia also uses the diffusible signal factor system (DSF) i.e. 2-undecenoic acid derivatives that are recognized by specific receptors resulting in changes in biofilm formation, motility and virulence...
January 11, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29319806/comparative-genomics-highlights-symbiotic-capacities-and-high-metabolic-flexibility-of-the-marine-genus-pseudovibrio
#20
Dennis Versluis, Bart Nijsse, Mohd Azrul Naim, Jasper J Koehorst, Jutta Wiese, Johannes F Imhoff, Peter J Schaap, Mark W J van Passel, Hauke Smidt, Detmer Sipkema
Pseudovibrio is a marine bacterial genus members of which are predominantly isolated from sessile marine animals, and particularly sponges. It has been hypothesised that Pseudovibrio spp. form mutualistic relationships with their hosts. Here, we studied Pseudovibrio phylogeny and genetic adaptations that may play a role in host colonization by comparative genomics of 31 Pseudovibrio strains, including 25 sponge isolates. All genomes were highly similar in terms of encoded core metabolic pathways, albeit with substantial differences in overall gene content...
January 8, 2018: Genome Biology and Evolution
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