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https://www.readbyqxmd.com/read/28944872/isoflurane-exposure-regulates-the-cell-viability-and-bdnf-expression-of-astrocytes-via-upregulation-of-trek%C3%A2-1
#1
Cui-Hong Zhou, Ya-Hong Zhang, Fen Xue, Shan-Shan Xue, Yun-Chun Chen, Ting Gu, Zheng-Wu Peng, Hua-Ning Wang
Neonatal isoflurane exposure in rodents disrupts hippocampal cognitive functions, including learning and memory, and astrocytes may have an important role in this process. However, the molecular mechanisms underlying this disruption are not fully understood. The present study investigated the role of TWIK‑related K+ channel (TREK‑1) in isoflurane‑induced cognitive impairment. Lentiviruses were used to overexpress or knockdown TREK‑1 in astrocytes exposed to increasing concentrations of isoflurane or O2 for 2 h...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944399/neurobehavioral-effects-and-biomarkers-of-sleep-loss-in-healthy-adults
#2
REVIEW
Namni Goel
PURPOSE OF REVIEW: This article reviews the neurobehavioral deficits resulting from sleep loss in adults, various countermeasures to mitigate these effects, and biomarkers to identify individual differences in neurobehavioral responses. RECENT FINDINGS: Total sleep deprivation and chronic sleep restriction increase the homeostatic sleep drive and diminish waking neurobehavioral functioning, producing deficits in attention, memory and cognitive speed, increases in sleepiness and fatigue, and unstable wakefulness...
September 25, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28943708/executive-functioning-deficits-increase-kindergarten-children-s-risk-for-reading-and-mathematics-difficulties-in-first-grade
#3
Paul L Morgan, Hui Li, George Farkas, Michael Cook, Wik Hung Pun, Marianne M Hillemeier
Whether executive functioning deficits result in children experiencing learning difficulties is presently unclear. Yet evidence for these hypothesized causal relations has many implications for early intervention design and delivery. We used a multi-year panel design, multiple criterion and predictor variable measures, extensive statistical control for potential confounds including autoregressive prior histories of both reading and mathematics difficulties, and additional epidemiological methods to preliminarily examine these hypothesized relations...
July 2017: Contemporary Educational Psychology
https://www.readbyqxmd.com/read/28943428/insulin-modulates-hippocampally-mediated-spatial-working-memory-via-glucose-transporter-4
#4
J Pearson-Leary, V Jahagirdar, J Sage, E C McNay
The insulin-regulated glucose transporter, GluT4, is a key molecule in peripheral insulin signaling. Although GluT4 is abundantly expressed in neurons of specific brain regions such as the hippocampus, the functional role of neuronal GluT4 is unclear. Here, we used pharmacological inhibition of GluT4-mediated glucose uptake to determine whether GluT4 mediates insulin-mediated glucose uptake in the hippocampus. Consistent with previous reports, we found that glucose utilization increased in the dorsal hippocampus of male rats during spontaneous alternation (SA), a hippocampally-mediated spatial working memory task...
September 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28942767/measuring-the-effect-of-soil-transmitted-helminth-infections-on-cognitive-function-in-children-systematic-review-and-critical-appraisal-of-evidence
#5
Kei Owada, Mark Nielsen, Colleen L Lau, Archie C A Clements, Laith Yakob, Ricardo J Soares Magalhães
Recently the role of soil-transmitted helminth (STH) infections in children's cognitive developmental impairment has been under scrutiny. We conducted a systematic review of the evidence for associations between STH infections and cognitive function of children using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. We aimed to identify the domains of cognitive function in three age strata (<24months, 24-59months and ≥60months) and critically appraise the general design protocol of the studies, with a focus on the cognitive function measurement tools used...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28941875/face-and-gaze-perception-in-borderline-personality-disorder-an-electrical-neuroimaging-study
#6
Cristina Berchio, Camille Piguet, Kornelia Gentsch, Anne-Lise Küng, Tonia A Rihs, Roland Hasler, Jean-Michel Aubry, Alexandre Dayer, Christoph M Michel, Nader Perroud
Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces...
September 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28941549/the-corticostriatal-adenosine-a2a-receptor-controls-maintenance-and-retrieval-of-spatial%C3%A2-working-memory
#7
Zhihui Li, Xingjun Chen, Tao Wang, Ying Gao, Fei Li, Long Chen, Jin Xue, Yan He, Yan Li, Wei Guo, Wu Zheng, Liping Zhang, Fenfen Ye, Xiangpeng Ren, Yue Feng, Piu Chan, Jiang-Fan Chen
BACKGROUND: Working memory (WM) taps into multiple executive processes including encoding, maintenance, and retrieval of information, but the molecular and circuit modulation of these WM processes remains undefined due to the lack of methods to control G protein-coupled receptor signaling with temporal resolution of seconds. METHODS: By coupling optogenetic control of the adenosine A2A receptor (A2AR) signaling, the Cre-loxP-mediated focal A2AR knockdown with a delayed non-match-to-place (DNMTP) task, we investigated the effect of optogenetic activation and focal knockdown of A2ARs in the dorsomedial striatum (n = 8 to 14 per group) and medial prefrontal cortex (n = 16 to 22 per group) on distinct executive processes of spatial WM...
August 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28941407/targeted-neurogenesis-pathway-based-gene-analysis-identifies-adora2a-associated-with-hippocampal-volume-in-mild-cognitive-impairment-and-alzheimer-s-disease
#8
Emrin Horgusluoglu-Moloch, Kwangsik Nho, Shannon L Risacher, Sungeun Kim, Tatiana Foroud, Leslie M Shaw, John Q Trojanowski, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Simon Lovestone, Andrew Simmons, Michael W Weiner, Andrew J Saykin
Alzheimer's disease (AD) patients display hippocampal atrophy, memory impairment, and cognitive decline. New neurons are generated throughout adulthood in 2 regions of the brain implicated in AD, the dentate gyrus of the hippocampus and the subventricular zone of the olfactory bulb. Disruption of this process contributes to neurodegenerative diseases including AD, and many of the molecular players in AD are also modulators of adult neurogenesis. However, the genetic mechanisms underlying adult neurogenesis in AD have been underexplored...
August 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28941032/are-patients-with-bipolar-disorder-and-comorbid-attention-deficit-hyperactivity-disorder-more-neurocognitively-impaired
#9
Imma Torres, Brisa Sole, Montse Corrales, Esther Jiménez, Sofia Rotger, Juan Francisco Serra-Pla, Irene Forcada, Vanesa Richarte, Ester Mora, Carlos Jacas, Nuria Gómez, Maria Mur, Francesc Colom, Eduard Vieta, Miquel Casas, Anabel Martinez-Aran, Jose M Goikolea, Josep A Ramos-Quiroga
OBJECTIVE: Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs). METHODS: This was a three-site study comprising 229 subjects: 70 patients with pBD, 23 with BD+ADHD, 50 with pADHD, and 86 HCs...
September 21, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28940977/atypical-neuronal-activation-during-a-spatial-working-memory-task-in-13-year-old-very-preterm-children
#10
Pia-Maria S H Arthursson, Deanne K Thompson, Megan Spencer-Smith, Jian Chen, Tim Silk, Lex W Doyle, Peter J Anderson
Children born very preterm (VP; <32 weeks' gestational age) are at risk for unfavorable outcomes in several cognitive domains, including spatial working memory (WM). The underlying neural basis of these cognitive impairments is poorly understood. We investigated differences in neuronal activation during spatial WM using a backward span (BS) task relative to a control (C) task in 45 VP children and 19 term-born controls aged 13 years. VP children showed significantly more activation in the bilateral superior frontal gyrus and significantly less activation in the left parahippocampal gyrus compared with controls...
September 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28940855/long-term-effects-of-cognitive-rehabilitation-on-brain-functional-outcome-and-cognition-in-parkinson-s-disease
#11
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
BACKGROUND: Cognitive rehabilitation has demonstrated efficacy in producing short-term cognitive and brain changes in Parkinson's disease (PD) patients. To date, no study has assessed the long-term effects of cognitive rehabilitation using neuroimaging techniques in PD. The aim was to assess the longitudinal effects of a 3-month cognitive rehabilitation program evaluating the cognitive, behavioural and neuroimaging changes after 18 months. METHODS: Fifteen PD patients underwent a cognitive, behavioural and neuroimaging assessment at pre-treatment (T0 ), post-treatment (T1 ) and after 18-months (T2 )...
September 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28940848/executive-function-and-functional-and-structural-brain-differences-in-middle-age-adults-with-autism-spectrum-disorder
#12
B Blair Braden, Christopher J Smith, Amiee Thompson, Tyler K Glaspy, Emily Wood, Divya Vatsa, Angela E Abbott, Samuel C McGee, Leslie C Baxter
There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older adults with ASD is understudied. We combined functional and structural neuroimaging and neuropsychological tests to examine differences between middle-aged men with ASD and matched neurotypical (NT) men. Participants (ASD, n = 16; NT, n = 17) aged 40-64 years were well-matched according to age, IQ (range: 83-131), and education (range: 9-20 years)...
September 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28940207/affective-priming-and-cognitive-load-event-related-potentials-suggest-an-interplay-of-implicit-affect-misattribution-and-strategic-inhibition
#13
Henning Gibbons, Laura-Effi Seib-Pfeifer, Judith Koppehele-Gossel, Robert Schnuerch
Prior research suggests that the affective priming effect denoting prime-congruent evaluative judgments about neutral targets preceded by affective primes increases when the primes are processed less deeply. This has been taken as evidence for greater affect misattribution. However, no study so far has combined an experimental manipulation of the depth of prime processing with the benefits of ERPs. Forty-seven participants made like/dislike responses about Korean ideographs following 800-ms affective prime words while 64-channel EEG was recorded...
September 21, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28940173/liquiritigenin-ameliorates-memory-and-cognitive-impairment-through-cholinergic-and-bdnf-pathways-in-the-mouse-hippocampus
#14
Yong-Hyun Ko, Seung-Hwan Kwon, Seok-Yong Lee, Choon-Gon Jang
Liquiritigenin (LQ), a flavonoid extracted from the radix of Glycyrrhiza, has anti-inflammatory and neuroprotective properties. In this study, we evaluated the cognitive enhancing effects of LQ on learning and memory impairments induced by scopolamine (0.5 mg/kg, i.p.), a muscarinic antagonist, using the Y-maze, passive avoidance, and novel object recognition tests. A single administration of LQ significantly improved scopolamine-induced cognitive impairments in these behavioral tests. In addition, LQ dramatically inhibited acetylcholinesterase and thiobarbituric acid reactive substance activities in the hippocampus of scopolamine-induced mice in a dose-dependent manner...
September 22, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28940127/diagnostic-accuracy-of-memory-measures-in-alzheimer-s-dementia-and-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#15
REVIEW
Gali H Weissberger, Jessica V Strong, Kayla B Stefanidis, Mathew J Summers, Mark W Bondi, Nikki H Stricker
With an increasing focus on biomarkers in dementia research, illustrating the role of neuropsychological assessment in detecting mild cognitive impairment (MCI) and Alzheimer's dementia (AD) is important. This systematic review and meta-analysis, conducted in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) standards, summarizes the sensitivity and specificity of memory measures in individuals with MCI and AD. Both meta-analytic and qualitative examination of AD versus healthy control (HC) studies (n = 47) revealed generally high sensitivity and specificity (≥ 80% for AD comparisons) for measures of immediate (sensitivity = 87%, specificity = 88%) and delayed memory (sensitivity = 89%, specificity = 89%), especially those involving word-list recall...
September 22, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28940086/music-related-reward-responses-predict-episodic-memory-performance
#16
Laura Ferreri, Antoni Rodriguez-Fornells
Music represents a special type of reward involving the recruitment of the mesolimbic dopaminergic system. According to recent theories on episodic memory formation, as dopamine strengthens the synaptic potentiation produced by learning, stimuli triggering dopamine release could result in long-term memory improvements. Here, we behaviourally test whether music-related reward responses could modulate episodic memory performance. Thirty participants rated (in terms of arousal, familiarity, emotional valence, and reward) and encoded unfamiliar classical music excerpts...
September 22, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28940045/a-neuronal-retuning-hypothesis-of-sentence-specificity-in-broca-s-area
#17
REVIEW
William G Matchin
It is clear that the left inferior frontal gyrus (LIFG) contributes in some fashion to sentence processing. While neuroimaging and neuropsychological evidence support a domain-general working memory function, recent neuroimaging data show that particular subregions of the LIFG, particularly the pars triangularis (pTri), show selective activation for sentences relative to verbal working memory and cognitive control tasks. These data suggest a language-specific function rather than a domain-general one. To resolve this apparent conflict, I propose separating claims of domain-generality and specificity independently for computations and representations-a given brain region may respond to a specific representation while performing a general computation over that representation, one shared with other systems...
September 22, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28939875/dietary-teasaponin-ameliorates-alteration-of-gut-microbiota-and-cognitive-decline-in-diet-induced-obese-mice
#18
Sen Wang, Xu-Feng Huang, Peng Zhang, Kelly A Newell, Hongqin Wang, Kuiyang Zheng, Yinghua Yu
A high-fat (HF) diet alters gut microbiota and promotes obesity related inflammation and cognitive impairment. Teasaponin is the major active component of tea, and has been associated with anti-inflammatory effects and improved microbiota composition. However, the potential protective effects of teasaponin, against HF diet-induced obesity and its associated alteration of gut microbiota, inflammation and cognitive decline have not been studied. In this study, obesity was induced in C57BL/6 J male mice by feeding a HF diet for 8 weeks, followed by treatment with oral teasaponin (0...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939709/topography-and-determinants-of-magnetic-resonance-imaging-mri-visible-perivascular-spaces-in-a-large-memory-clinic-cohort
#19
Sara Shams, Juha Martola, Andreas Charidimou, Mykol Larvie, Tobias Granberg, Mana Shams, Maria Kristoffersen-Wiberg, Lars-Olof Wahlund
BACKGROUND: Magnetic resonance imaging-visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid-β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. METHODS AND RESULTS: A total of 1504 patients undergoing memory clinic investigation and an associated brain magnetic resonance imaging scan were included in this cross-sectional study...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939668/neurogranin-a-synaptic-protein-is-associated-with-memory-independent-of-alzheimer-biomarkers
#20
Kaitlin B Casaletto, Fanny M Elahi, Brianne M Bettcher, John Neuhaus, Barbara B Bendlin, Sanjay Asthana, Sterling C Johnson, Kristine Yaffe, Cynthia Carlsson, Kaj Blennow, Henrik Zetterberg, Joel H Kramer
OBJECTIVE: To determine the association between synaptic functioning as measured via neurogranin in CSF and cognition relative to established Alzheimer disease (AD) biomarkers in neurologically healthy older adults. METHODS: We analyzed CSF concentrations of neurogranin, β-amyloid (Aβ42), phosphorylated tau (p-tau), and total tau (t-tau) among 132 neurologically normal older adults (mean 64.5, range 55-85), along with bilateral hippocampal volumes and a measure of episodic memory (Auditory Verbal Learning Test, delayed recall)...
September 22, 2017: Neurology
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