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https://www.readbyqxmd.com/read/29676237/ultramicronized-palmitoylethanolamide-effects-on-sleep-wake-rhythm-and-neuropathic-pain-phenotypes-in-patients-with-carpal-tunnel-syndrome-an-open-label-randomized-controlled-study
#1
Maurizio Evangelista, Vitale Cilli, Rocco De Vitis, Arturo Militerno, Francesco Fanfani
BACKGROUND: Patients with carpal tunnel syndrome often suffer from fragmentary sleep. This study was designed to assess the effectiveness of treatment with ultramicronized palmitoylethanolamide in reducing pain intensity and in improving quality of sleep in patients with neuropathic pain due to carpal tunnel syndrome. METHODS: An open, controlled study was conducted on 42 patients awaiting carpal tunnel syndrome surgery, suffering from sleep disorders and painful symptoms and randomized into two groups...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29675716/disturbances-of-sleep-and-alertness-in-parkinson-s-disease
#2
REVIEW
Aleksandar Videnovic
PURPOSE OF REVIEW: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact on the daily lives of PD patients, poorly understood mechanisms, and limited treatment options. In this review, we discuss the most common sleep disorders in PD and present recent investigations that have broadened our understanding of the epidemiology, clinical manifestations, diagnosis, and treatment of disturbed sleep and alertness in PD...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29674967/no-acute-effects-of-cannabidiol-on-the-sleep-wake-cycle-of-healthy-subjects-a-randomized-double-blind-placebo-controlled-crossover-study
#3
Ila M P Linares, Francisco S Guimaraes, Alan Eckeli, Ana C S Crippa, Antonio W Zuardi, Jose D S Souza, Jaime E Hallak, José A S Crippa
Cannabidiol (CBD) is a component of Cannabis sativa that has a broad spectrum of potential therapeutic effects in neuropsychiatric and other disorders. However, few studies have investigated the possible interference of CBD on the sleep-wake cycle. The aim of the present study was to evaluate the effect of a clinically anxiolytic dose of CBD on the sleep-wake cycle of healthy subjects in a crossover, double-blind design. Twenty-seven healthy volunteers that fulfilled the eligibility criteria were selected and allocated to receive either CBD (300 mg) or placebo in the first night in a double-blind randomized design (one volunteer withdrew from the study)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29673929/sleep-disorders-in-adolescents-and-young-adults-insights-into-types-relationship-to-obesity-and-high-altitude-and-possible-lines-of-management
#4
REVIEW
Ahmed M Kabel, Amani M Al Thumali, Khayriah A Aldowiala, Raghad D Habib, Shoroq S Aljuaid, Huda A Alharthi
A sleep disorder is a medical disorder of the sleep pattern of a person that may be serious enough to interfere with normal physical, mental and emotional functioning. Disruptions in sleep can be caused by a variety of causes, from teeth grinding to night terrors. Sleep disorders are usually prevalent among adolescents and young adults, possibly due to factors related to life style, dietary habits, hormonal and emotional disturbances. Other factors that may precipitate sleep disorders include environmental, psychological and genetic factors...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29671707/prediction-of-cognitive-performance-and-subjective-sleepiness-using-a-model-of-arousal-dynamics
#5
Svetlana Postnova, Steven W Lockley, Peter A Robinson
A model of arousal dynamics is applied to predict objective performance and subjective sleepiness measures, including lapses and reaction time on a visual Performance Vigilance Test (vPVT), performance on a mathematical addition task (ADD), and the Karolinska Sleepiness Scale (KSS). The arousal dynamics model is comprised of a physiologically based flip-flop switch between the wake- and sleep-active neuronal populations and a dynamic circadian oscillator, thus allowing prediction of sleep propensity. Published group-level experimental constant routine (CR) and forced desynchrony (FD) data are used to calibrate the model to predict performance and sleepiness...
April 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29665518/early-intervention-for-adolescents-at-risk-for-bipolar-disorder-a-pilot-randomized-trial-of-interpersonal-and-social-rhythm-therapy-ipsrt
#6
Tina R Goldstein, John Merranko, Megan Krantz, Matthew Garcia, Peter Franzen, Jessica Levenson, David Axelson, Boris Birmaher, Ellen Frank
OBJECTIVE: To conduct a pilot randomized trial of Interpersonal and Social Rhythm Therapy plus Data-Informed Referral (IPSRT + DIR) versus DIR-alone for adolescents at-risk for bipolar disorder (BP). METHOD: Eligible participants included youth (12-18) with a BP parent; youth with BP were excluded. Participants (n = 42) were randomized to receive IPSRT + DIR to treat any psychiatric disorders present at baseline, or DIR-alone. A blind evaluator assessed outcomes at baseline, 3- and 6-months...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29663636/sleep-and-mood-during-hospitalization-for-high-dose-chemotherapy-and-hematopoietic-rescue-in-pediatric-medulloblastoma
#7
Danielle M Graef, Valerie McLaughlin Crabtree, Deo Kumar Srivastava, Chenghong Li, Michele Pritchard, Pamela S Hinds, Belinda Mandrell
OBJECTIVE: Disrupted sleep is common in pediatric cancer, which is associated with psychological distress and may impact neural recovery. Information regarding sleep during pediatric brain tumor treatment is limited. This study aimed to describe objective sleep-wake patterns and examine the sleep-mood relation in youth hospitalized for intensive chemotherapy and stem cell rescue. METHODS: Participants included 37 patients (M age =9.6 ± 4.2 years) enrolled on a medulloblastoma protocol (SJMB03) and their parents...
April 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29662454/the-biological-clock-a-pivotal-hub-in-non-alcoholic-fatty-liver-disease-pathogenesis
#8
REVIEW
Gianluigi Mazzoccoli, Salvatore De Cosmo, Tommaso Mazza
Non-alcoholic fatty liver disease (NAFLD) is the most frequent hepatic pathology in the Western world and may evolve into steatohepatitis (NASH), increasing the risk of cirrhosis, portal hypertension and hepatocellular carcinoma. NAFLD derives from the accumulation of hepatic fat due to discrepant free fatty acid metabolism. Other factors contributing to this are deranged nutrients and bile acids fluxes as well as alterations in nuclear receptors, hormones, and intermediary metabolites, which impact on signaling pathways involved in metabolism and inflammation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29662440/electrophysiological-properties-of-melanin-concentrating-hormone-and-orexin-neurons-in-adolescent-rats
#9
Victoria Linehan, Michiru Hirasawa
Orexin and melanin-concentrating hormone (MCH) neurons have complementary roles in various physiological functions including energy balance and the sleep/wake cycle. in vitro electrophysiological studies investigating these cells typically use post-weaning rodents, corresponding to adolescence. However, it is unclear whether these neurons are functionally mature at this period and whether these studies can be generalized to adult cells. Therefore, we examined the electrophysiological properties of orexin and MCH neurons in brain slices from post-weaning rats and found that MCH neurons undergo an age-dependent reduction in excitability, but not orexin neurons...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29660304/circadian-rhythm-resynchronization-improved-isoflurane-induced-cognitive-dysfunction-in-aged-mice
#10
Jia Song, Shuaishuai Chu, Yin Cui, Yue Qian, Xiuxiu Li, Fangxia Xu, Xueming Shao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Postoperative cognitive dysfunction (POCD) is a common clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery. Advanced age is a significant independent risk factor for POCD. We previously reported that in young mice, sleep-wake rhythm is involved in the isoflurane-induced memory impairment. In present study, we sought to determine whether advanced age increased the risk of POCD through aggravated and prolonged post-anesthetic circadian disruption in the elderly. We constructed POCD model by submitting the mice to 5-h 1...
April 13, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29660025/morning-cortisol-is-associated-with-stress-and-sleep-in-elite-military-men-a-brief-report
#11
Lisa M Hernández, Rachel R Markwald, Shiloah A Kviatkovsky, Lori N Perry, Marcus K Taylor
Introduction: Accumulating evidence suggests that trends in salivary cortisol after awakening may be reliable biological predictors of morbidity and mortality. In a sample of elite military men, our lab recently established summary parameters of morning cortisol as well as their stability across 2 d of repeated sampling. Materials and Methods: In this follow-on study, we evaluated summary parameters and their relationships to theoretically relevant demographic (i...
April 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29658807/effect-of-bright-light-therapy-on-delayed-sleep-wake-cycle-and-reaction-time-of-athletes-participating-in-the-rio-2016-olympic-games
#12
João Paulo P Rosa, Andressa Silva, Dayane F Rodrigues, Mário Antônio Simim, Fernanda V Narciso, Sergio Tufik, Jorge J Bichara, Sebastian Rafael D Pereira, Sidney C Da Silva, Marco Tulio de Mello
This study investigated the effect of using an artificial bright light on the entrainment of the sleep/wake cycle as well as the reaction times of athletes before the Rio 2016 Olympic Games. A total of 22 athletes from the Brazilian Olympic Swimming Team were evaluated, with the aim of preparing them to compete at a time when they would normally be about to go to bed for the night. During the 8-day acclimatization period, their sleep/wake cycles were assessed by actigraphy, with all the athletes being treated with artificial light therapy for between 30 and 45 min (starting at day 3)...
April 16, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29657561/habitual-sleep-and-human-plasma-metabolomics
#13
Qian Xiao, Andriy Derkach, Steven C Moore, Wei Zheng, Xiao-Ou Shu, Fangyi Gu, Neil E Caporaso, Joshua N Sampson, Charles E Matthews
Introduction: Sleep plays an important role in cardiometabolic health. The sleep-wake cycle is partially driven by the endogenous circadian clock, which governs a range of metabolic pathways. The association between sleep and cardiometabolic health may be mediated by alterations of the human metabolome. Objectives: To better understand the biological mechanism underlying the association between sleep and health, we examined human plasma metabolites in relation to sleep duration and sleep timing...
May 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29652889/the-rostromedial-tegmental-nucleus-is-essential-for-non-rapid-eye-movement-sleep
#14
Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Dou Yin, Chen-Yao Wang, Yu-Dong Yan, Dian-Ru Wang, Xiang-Shan Yuan, Chen-Bo Ye, Wei Guo, Wei-Min Qu, Yoan Cherasse, Michael Lazarus, Yu-Qiang Ding, Zhi-Li Huang
The rostromedial tegmental nucleus (RMTg), also called the GABAergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. Whether the RMTg is involved in sleep-wake regulation is unknown. In the present study, pharmacogenetic activation of rat RMTg neurons promoted non-rapid eye movement (NREM) sleep with increased slow-wave activity (SWA). Conversely, rats after neurotoxic lesions of 8 or 16 days showed decreased NREM sleep with reduced SWA at lights on, which persisted until after lesions of 25 days...
April 13, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29643770/neural-control-of-startle-induced-locomotion-by-the-mushroom-bodies-and-associated-neurons-in-drosophila
#15
Jun Sun, An Qi Xu, Julia Giraud, Haiko Poppinga, Thomas Riemensperger, André Fiala, Serge Birman
Startle-induced locomotion is commonly used in Drosophila research to monitor locomotor reactivity and its progressive decline with age or under various neuropathological conditions. A widely used paradigm is startle-induced negative geotaxis (SING), in which flies entrapped in a narrow column react to a gentle mechanical shock by climbing rapidly upwards. Here we combined in vivo manipulation of neuronal activity and splitGFP reconstitution across cells to search for brain neurons and putative circuits that regulate this behavior...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29624593/work-routines-moderate-the-association-between-eveningness-and-poor-psychological-well-being
#16
Felipe Gutiérrez Carvalho, Camila Morelatto de Souza, Maria Paz Loayza Hidalgo
Well-being is a useful screening method for the detection of mood disorders. Evidence associating psychological well-being with sleep-wake patterns exists, as well as associations with sleep-wake patterns, work-related parameters, and perceived self-efficacy. Despite the growing research regarding the relationship between these factors and mental health, there are few studies that analyze them together. OBJECTIVE: To investigate if the association between sleep-wake patterns and psychological well-being is mediated or moderated by perceived self-efficacy, work flexibility and work routines...
2018: PloS One
https://www.readbyqxmd.com/read/29623062/lucid-dreaming-intensity-but-not-frequency-is-inversely-related-to-psychopathology
#17
Liat Aviram, Nirit Soffer-Dudek
Lucid dreaming (LD) is awareness that one is dreaming, during the dream state. However, some define and assess LD relying also on controlling dream events, although control is present only in a subset of lucid dreams. LD has been claimed to represent well-being, and has even been used as a therapeutic agent. Conversely, LD is associated with mixed sleep-wake states, which are related to bizarre cognitions, stress, and psychopathology, and have been construed as arousal permeating and disrupting sleep. We propose that previous conflicting findings regarding relations between LD and both psychopathology and well-being, stem from the non-differentiated assessment of frequency and control...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29614850/factor-analysis-of-delirium-in-elderly-using-the-korean-version-of-delirium-rating-scale-revised-98
#18
Gahye Noh, Insun Kwon, Miji Lee, So Hyun Ahn, Jeong Lan Kim
Objective: This study aimed to identify the core symptoms of delirium, particularly in elderly people associated with major risk factors, using the Korean version of the Delirium Rating Scale-Revised-98. Methods: The study sample consisted of 200 patients (mean age: 72.7±3.9 years, male: 68.5%) who had been diagnosed with delirium. Exploratory factor analysis was used to investigate the factor structure, and confirmatory factor analysis was used to evaluate the goodness of fit of the results...
April 5, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29609703/diagnostic-and-treatment-challenges-of-sighted-non-24-hour-sleep-wake-disorder
#19
Roneil G Malkani, Sabra M Abbott, Kathryn J Reid, Phyllis C Zee
STUDY OBJECTIVES: To report the diagnostic and treatment challenges of sighted non-24-hour sleep-wake disorder (N24SWD). METHODS: We report a series of seven sighted patients with N24SWD clinically evaluated by history and sleep diaries, and when available wrist actigraphy and salivary melatonin levels, and treated with timed melatonin and bright light therapy. RESULTS: Most patients had a history of a delayed sleep-wake pattern prior to developing N24SWD...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29602910/neurocognition-sleep-and-pet-findings-in-type-2-vs-type-1-narcolepsy
#20
Yu-Shu Huang, Ing-Tsung Hsiao, Feng-Yuan Liu, Fang-Ming Hwang, Kuang-Lin Lin, Wen-Cheng Huang, Christian Guilleminault
OBJECTIVE: To analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective Neuropsychologic tests, and sleep findings. METHODS: Data collection included comprehensive clinical investigation, study of sleep/wake with actigraphy, polysomnography, Multiple Sleep Latency Test, human leukocyte antigen typing,18 F-fluorodeoxyglucose PET, and cognitive tests obtained from 29 patients with type 2 narcolepsy, 104 patients with type 1 narcolepsy, and 26 sex- and age-matched normal control individuals...
March 30, 2018: Neurology
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