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https://www.readbyqxmd.com/read/29456519/why-don-t-you-go-to-bed-on-time-a-daily-diary-study-on-the-relationships-between-chronotype-self-control-resources-and-the-phenomenon-of-bedtime-procrastination
#1
Jana Kühnel, Christine J Syrek, Anne Dreher
Background: This daily diary study investigates the phenomenon of bedtime procrastination. Bedtime procrastination is defined as going to bed later than intended, without having external reasons for doing so. We highlight the role chronotype (interindividual differences in biological preferences for sleep-wake-times) plays for bedtime procrastination. Moreover, we challenge the view that bedtime procrastination is the result of a lack of self-regulatory resources by investigating momentary self-regulatory resources as a predictor of day-specific bedtime procrastination...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29456505/deletion-of-trace-amine-associated-receptor-1-attenuates-behavioral-responses-to-caffeine
#2
Michael D Schwartz, Jeremiah B Palmerston, Diana L Lee, Marius C Hoener, Thomas S Kilduff
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Selective TAAR1 full and partial agonists exhibit similar pro-cognitive, antidepressant- and antipsychotic-like properties in rodents and non-human primates, suggesting TAAR1 as a novel target for the treatment of neurological and psychiatric disorders. We previously reported that TAAR1 partial agonists are wake-promoting in rats and mice, and that TAAR1 knockout (KO) and overexpressing mice exhibit altered sleep-wake and EEG spectral composition...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29455555/employment-status-is-related-to-sleep-problems-in-adults-with-autism-spectrum-disorder-and-no-comorbid-intellectual-impairment
#3
Emma K Baker, Amanda L Richdale, Agnes Hazi
Both sleep problems and unemployment are common in adults with autism spectrum disorder; however, little research has explored this relationship in this population. This study aimed to explore factors that may be associated with the presence of an International Classification of Sleep Disorders-Third Edition defined sleep disorder in adults with autism spectrum disorder (IQ > 80). A total of 36 adults with autism spectrum disorder and 36 controls were included in the study. Participants completed a 14-day actigraphy assessment and questionnaire battery...
February 1, 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29454715/-sleepiness-continuous-positive-airway-pressure-and-the-obstructive-sleep-apnea-hypopnea-syndrome
#4
REVIEW
L Lerousseau
Excessive daytime sleepiness is a major symptom in cases of the obstructive sleep apnea-hypopnea syndrome. Most often, it is vastly improved by treatment with continuous positive airway pressure (CPAP). The most effective way to confirm its disappearance is through wakefulness maintenance testing. If residual sleepiness remains, despite CPAP, further diagnostic investigation must be carried out. Firstly, it must be assessed whether the treatment is fully effective (apnea hypopnea index<10/h) by examining flow limitations under treatment (polysomnography) and whether it is sufficiently used (>6h/night)...
February 14, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29453399/association-of-sleep-and-circadian-activity-rhythm-with-emotional-face-processing-among-12-month-old-infants
#5
Wanqi Sun, Shirley Xin Li, Guanghai Wang, Shumei Dong, Yanrui Jiang, Karen Spruyt, Jiefan Ling, Qi Zhu, Tatia Mei-Chun Lee, Fan Jiang
Sleep and circadian rhythmicity both play an important role in human's cognitive functioning, yet the way in which early development of sleep and circadian rhythm affects cognitive processes and social learning in infants remains less understood. We examined the association of sleep and circadian activity rhythm (CAR) with face and emotional information processing in 12-month old infants. Face processing was measured by eye tracking, whereby infants' scanning patterns and pupil dilations were calculated when they were presented with neutral, pleasant and unpleasant faces...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445534/delayed-sleep-wake-phase-disorder
#6
REVIEW
Alexander D Nesbitt
Delayed sleep-wake phase disorder (DSWPD) is the most commonly encountered of the circadian rhythm sleep-wake disorders (CRSDs), and is often confused with sleep initiation insomnia. It typically emerges in teenage years and persists into adulthood. In essence, people with the disorder have an abnormally delayed major sleep episode relative to the dark phase of the solar cycle, and hence great difficulty initiating sleep at an appropriately early time, and, as a knock-on effect, waking at a desirable time in the morning, leading to chronic, and often quite severe sleep restriction trying to conform to a 9 to 5 schedule...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29441659/genetic-polymorphisms-associated-with-circadian-rhythm-dysregulation-provide-new-perspectives-on-bipolar-disorder
#7
REVIEW
Thomaz Oliveira, Victor Marinho, Valécia Carvalho, Francisco Magalhães, Kaline Rocha, Carla Ayres, Silmar Teixeira, Monara Nunes, Victor Hugo Bastos, Giovanny R Pinto
OBJECTIVES: The objective of this study was to present a broad view of how genetic polymorphisms in genes that control the rhythmicity and function of circadian rhythm may influence the etiology, pathophysiology and treatment of bipolar disorder (BD). METHODS: A bibliographic search was performed to identify and select papers reporting studies on variations in circadian genes and BD. A search of Medline, Google Scholar, Scopus, and Web of Science was carried out to review the literature...
February 13, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29438803/sleep-state-dependence-of-optogenetically-evoked-responses-in-neuronal-nitric-oxide-synthase-positive-cells-of-the-cerebral-cortex
#8
Dmitry Gerashchenko, Michelle A Schmidt, Mark R Zielinski, Michele E Moore, Jonathan P Wisor
Slow-wave activity (SWA) in the electroencephalogram during slow-wave sleep (SWS) varies as a function of sleep-wake history. A putative sleep-active population of neuronal nitric oxide synthase (nNOS)-containing interneurons in the cerebral cortex, defined as such by the expression of Fos in animals euthanized after protracted deep sleep, may be a local regulator of SWA. We investigated whether electrophysiological responses to activation of these cells are consistent with their role of a local regulator of SWA...
February 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29437238/a-unified-model-of-melatonin-6-sulfatoxymelatonin-and-sleep-dynamics
#9
Romesh G Abeysuriya, Steven W Lockley, Peter A Robinson, Svetlana Postnova
A biophysical model of the key aspects of melatonin synthesis and excretion has been developed, which is able to predict experimental dynamics of melatonin in plasma and saliva, and of its urinary metabolite 6-sulfatoxymelatonin (aMT6s). This new model is coupled to an established model of arousal dynamics, which predicts sleep and circadian dynamics based on light exposure and times of wakefulness. The combined model thus predicts melatonin levels over the sleep-wake/dark-light cycle and enables prediction of melatonin-based circadian phase markers, such as dim light melatonin onset (DLMO) and aMT6s acrophase under conditions of normal sleep and circadian misalignment...
February 13, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29434539/sleep-and-sedative-states-induced-by-targeting-the-histamine-and-noradrenergic-systems
#10
REVIEW
Xiao Yu, Nicholas P Franks, William Wisden
Sedatives target just a handful of receptors and ion channels. But we have no satisfying explanation for how activating these receptors produces sedation. In particular, do sedatives act at restricted brain locations and circuitries or more widely? Two prominent sedative drugs in clinical use are zolpidem, a GABA A receptor positive allosteric modulator, and dexmedetomidine (DEX), a selective α2 adrenergic receptor agonist. By targeting hypothalamic neuromodulatory systems both drugs induce a sleep-like state, but in different ways: zolpidem primarily reduces the latency to NREM sleep, and is a controlled substance taken by many people to help them sleep; DEX produces prominent slow wave activity in the electroencephalogram (EEG) resembling stage 2 NREM sleep, but with complications of hypothermia and lowered blood pressure-it is used for long term sedation in hospital intensive care units-under DEX-induced sedation patients are arousable and responsive, and this drug reduces the risk of delirium...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29431649/sleep-deprivation-distinctly-alters-glutamate-transporter-1-apposition-and-excitatory-transmission-to-orexin-and-mch-neurons
#11
Chantalle Briggs, Michiru Hirasawa, Kazue Semba
Glutamate transporter 1 (GLT1) is the main astrocytic transporter that shapes glutamatergic transmission in the brain. However, whether this transporter modulates sleep/wake regulatory neurons is unknown. Using quantitative immunohistochemical analysis, we assessed perisomatic GLT1 apposition with sleep/wake neurons in the male rat following 6-h sleep deprivation (SD) or following 6-h undisturbed conditions when animals were mostly asleep (Rest). We found that SD decreased perisomatic GLT1 apposition with wake-promoting orexin (ORX) neurons in the lateral hypothalamus (LH) compared to Rest...
February 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29420933/precisely-timed-nicotinic-activation-drives-sst-inhibition-in-neocortical-circuits
#12
Joanna Urban-Ciecko, Jean-Sebastien Jouhanneau, Stephanie E Myal, James F A Poulet, Alison L Barth
Sleep, waking, locomotion, and attention are associated with cell-type-specific changes in neocortical activity. The effect of brain state on circuit output requires understanding of how neuromodulators influence specific neuronal classes and their synapses, with normal patterns of neuromodulator release from endogenous sources. We investigated the state-dependent modulation of a ubiquitous feedforward inhibitory motif in mouse sensory cortex, local pyramidal (Pyr) inputs onto somatostatin (SST)-expressing interneurons...
February 7, 2018: Neuron
https://www.readbyqxmd.com/read/29420828/time-to-rethink-sleep-quality-psqi-scores-reflect-sleep-quality-on-workdays
#13
Luísa K Pilz, Lena Katharina Keller, David Lenssen, Till Roenneberg
The Pittsburgh Sleep Quality Index (PSQI) is the most common measure of sleep quality. Its questions refer to "usual" sleep habits during the last month. Considering how different sleep-wake behavior can be between work- and work-free days, we hypothesized that sleep quality should show similar differences.We investigated these potential differences in a cross-sectional online study using the original and two adapted versions of the PSQI that replaced "usual" by explicitly referring to sleep on work- or work-free days...
February 6, 2018: Sleep
https://www.readbyqxmd.com/read/29415552/eveningness-is-associated-with-poor-sleep-quality-and-negative-affect-in-obsessive-compulsive-disorder
#14
Péter Simor, András Harsányi, Kata Csigó, Gergely Miklós, Alpár Sándor Lázár, Gyula Demeter
Background Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive behaviors that severely encumber daily functioning. OCD patients seem to exhibit sleep disturbances, especially delayed bedtimes that reflect disrupted circadian rhythmicity. Morningness-eveningness is a fundamental factor reflecting individual variations in diurnal preferences related to sleep and waking activities. Eveningness reflecting a delayed sleep-wake timing has repeatedly been associated with sleep problems and negative affect (NA)...
February 8, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29412982/circadian-rhythm-sleep-wake-disorders-in-older-adults
#15
REVIEW
Jee Hyun Kim, Jeanne F Duffy
The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows wakefulness throughout the day and a long consolidated sleep episode at night. Mismatch between the desired timing of sleep and the ability to fall and remain asleep is a hallmark of the circadian rhythm sleep-wake disorders. This article discusses changes in circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep-wake disorders; and how neurologic diseases in older patients affect circadian rhythms and sleep...
March 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29412824/ghrelin-regulation-of-glucose-metabolism
#16
Anne-Laure Poher, Matthias H Tschöp, Timo D Müller
The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH) releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and adiposity by acting on the hypothalamic melanocortinergic system. Subsequently, ghrelin was found to exert a series of metabolic effects, overall testifying ghrelin a pleiotropic nature of broad pharmacological interest. Ghrelin acts through the growth hormone secretagogue-receptor (GHS-R), a seven transmembrane G protein-coupled receptor with high expression in the anterior pituitary, pancreatic islets, thyroid gland, heart and various regions of the brain...
February 2018: Peptides
https://www.readbyqxmd.com/read/29410741/validation-of-midsagittal-jaw-movements-to-measure-sleep-in-healthy-adults-by-comparison-with-actigraphy-and-polysomnography
#17
Bassam Chakar, Frédéric Senny, Anne-Lise Poirrier, Laurent Cambron, Julien Fanielle, Robert Poirrier
OBJECTIVE: In a device based on midsagittal jaw movements analysis, we assessed a sleep-wake automatic detector as an objective method to measure sleep in healthy adults by comparison with wrist actigraphy against polysomnography (PSG). METHODS: Simultaneous and synchronized in-lab PSG, wrist actigraphy and jaw movements were carried out in 38 healthy participants. Epoch by epoch analysis was realized to assess the ability to sleep-wake distinction. Sleep parameters as measured by the three devices were compared...
July 2017: Sleep Science
https://www.readbyqxmd.com/read/29410739/retrospectively-reported-month-to-month-variation-in-sleeping-problems-of-people-naturally-exposed-to-high-amplitude-annual-variation-in-daylength-and-or-temperature
#18
Arcady A Putilov
Compared to literature on seasonal variation in mood and well-being, reports on seasonality of trouble sleeping are scarce and contradictive. To extend geography of such reports on example of people naturally exposed to high-amplitude annual variation in daylength and/or temperature. Participants were the residents of Turkmenia, West Siberia, South and North Yakutia, Chukotka, and Alaska. Health and sleep-wake adaptabilities, month-to-month variation in sleeping problems, well-being and behaviors were self-assessed...
July 2017: Sleep Science
https://www.readbyqxmd.com/read/29410179/envelope-analysis-links-oscillatory-and-arrhythmic-eeg-activities-to-two-types-of-neuronal-synchronization
#19
Javier Diaz, Alejandro Bassi, Alex Coolen, Ennio A Vivaldi, Juan-Carlos Letelier
Traditionally, EEG is understood as originating from the synchronous activation of neuronal populations that generate rhythmic oscillations in specific frequency bands. Recently, new neuronal dynamics regimes have been identified (e.g. neuronal avalanches) characterized by irregular or arrhythmic activity. In addition, it is starting to be acknowledged that broadband properties of EEG spectrum (following a 1/f law) are tightly linked to brain function. Nevertheless, there is still no theoretical framework accommodating the coexistence of these two EEG phenomenologies: rhythmic/narrowband and arrhythmic/broadband...
February 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29403350/the-experience-elicited-by-hallucinogens-presents-the-highest-similarity-to-dreaming-within-a-large-database-of-psychoactive-substance-reports
#20
Camila Sanz, Enzo Tagliazucchi
Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear a high resemblance to the dreams and dreamlike experiences occurring naturally during the sleep-wake cycle. Recent studies in humans have provided neurophysiological evidence supporting this hypothesis. However, a rigorous comparative analysis of the phenomenology ("what it feels like" to experience these states) is currently lacking. We investigated the semantic similarity between a large number of subjective reports of psychoactive substances and reports of high/low lucidity dreams, and found that the highest-ranking substance in terms of the similarity to high lucidity dreams was the serotonergic psychedelic lysergic acid diethylamide (LSD), whereas the highest-ranking in terms of the similarity to dreams of low lucidity were plants of the Datura genus, rich in deliriant tropane alkaloids...
2018: Frontiers in Neuroscience
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