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https://www.readbyqxmd.com/read/28089853/region-specific-increases-in-fosb-%C3%AE-fosb-immunoreactivity-in-the-rat-brain-in-response-to-chronic-sleep-restriction
#1
Shannon Hall, Samüel Deurveilher, Kristin Robin Ko, Joan Burns, Kazue Semba
Using a rat model of chronic sleep restriction (CSR) featuring periodic sleep deprivation with slowly rotating wheels (3h on/1h off), we previously observed that 99h of this protocol induced both homeostatic and allostatic (adaptive) changes in physiological and behavioural measures. Notably, the initial changes in sleep intensity and attention performance gradually adapted during CSR despite accumulating sleep loss. To identify brain regions involved in these responses, we used FosB/ΔFosB immunohistochemistry as a marker of chronic neuronal activation...
January 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28078839/widespread-membrane-potential-changes-and-cardiorespiratory-synchronization-involved-in-anxiety-and-sleep-wake-transitions
#2
R Jerath, S M Cearley, M Jensen
Located within the ascending reticular activating system are nuclei which release neurotransmitters such as acetylcholine, serotonin, dopamine, and norepinephrine. These nuclei have widespread projections that extend into the limbic system and throughout cortex. Activation of these neurotransmitters during awake states leads to arousal, while inhibition leads to the loss of consciousness experienced during slow-wave sleep. Previously, we proposed a mechanism in which cardiorespiratory synchronization may underlie the widespread hyperpolarization that occurs throughout the brain during slow-wave sleep...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28076377/comparative-analysis-of-vertebrate-diurnal-circadian-transcriptomes
#3
Greg Boyle, Kerstin Richter, Henry D Priest, David Traver, Todd C Mockler, Jeffrey T Chang, Steve A Kay, Ghislain Breton
From photosynthetic bacteria to mammals, the circadian clock evolved to track diurnal rhythms and enable organisms to anticipate daily recurring changes such as temperature and light. It orchestrates a broad spectrum of physiology such as the sleep/wake and eating/fasting cycles. While we have made tremendous advances in our understanding of the molecular details of the circadian clock mechanism and how it is synchronized with the environment, we still have rudimentary knowledge regarding its connection to help regulate diurnal physiology...
2017: PloS One
https://www.readbyqxmd.com/read/28072860/hyperbilirubinemia-influences-sleep-wake-cycles-of-term-newborns-in-a-non-linear-manner
#4
Lian Zhang, Yanxia Zhou, Xufang Li, Tingting Cheng
Hyperbilirubinemia is a common cause for irreversible neuronal influence in the brain of term newborns, while the feature of neurological symptoms associated with hyperbilirubinemia has not been well characterized yet. In the present study, we examined a total of 203 neonates suffering from hyperbilirubinemia with a bedside amplitude-integrated Electroencephalography (aEEG) device, in order to determine whether there is any special change in sleep-wake cycles (SWCs). Among these patients, 14 cases showed no recognizable SWCs with the total serum bilirubin (TSB) level at 483...
2017: PloS One
https://www.readbyqxmd.com/read/28071711/transient-anhedonia-phenotype-and-altered-circadian-timing-of-behaviour-during-night-time-dim-light-exposure-in-per3-mice-but-not-wildtype-mice
#5
Bruno Jacson Martynhak, Alexandra L Hogben, Panos Zanos, Polymnia Georgiou, Roberto Andreatini, Ian Kitchen, Simon N Archer, Malcolm von Schantz, Alexis Bailey, Daan R van der Veen
Industrialisation greatly increased human night-time exposure to artificial light, which in animal models is a known cause of depressive phenotypes. Whilst many of these phenotypes are 'direct' effects of light on affect, an 'indirect' pathway via altered sleep-wake timing has been suggested. We have previously shown that the Period3 gene, which forms part of the biological clock, is associated with altered sleep-wake patterns in response to light. Here, we show that both wild-type and Per3(-/-) mice showed elevated levels of circulating corticosterone and increased hippocampal Bdnf expression after 3 weeks of exposure to dim light at night, but only mice deficient for the PERIOD3 protein (Per3(-/-)) exhibited a transient anhedonia-like phenotype, observed as reduced sucrose preference, in weeks 2-3 of dim light at night, whereas WT mice did not...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069978/author-response-role-of-sleep-disordered-breathing-and-sleep-wake-disturbances-for-stroke-and-stroke-recovery
#6
Dirk M Hermann, Claudio L Bassetti
No abstract text is available yet for this article.
January 10, 2017: Neurology
https://www.readbyqxmd.com/read/28069977/letter-re-role-of-sleep-disordered-breathing-and-sleep-wake-disturbances-for-stroke-and-stroke-recovery
#7
Dietmar Fuchs, Barbara Strasser
No abstract text is available yet for this article.
January 10, 2017: Neurology
https://www.readbyqxmd.com/read/28066802/development-and-psychometric-evaluation-of-the-children-s-sleep-wake-scale
#8
Monique K LeBourgeois, John R Harsh
OBJECTIVE: To describe the development and psychometric evaluation of the Children's Sleep-Wake Scale (CSWS), a caregiver-report measure of behavioral sleep quality in 2- to 8-year-old children. DESIGN: Five studies using independent samples were completed to generate, refine, and finalize the item pool, as well as to confirm the factor structure and to assess the reliability and validity of the CSWS. SETTING: Field. MEASURES: CSWS, sleep diary, and actigraphy...
September 2016: Sleep Health
https://www.readbyqxmd.com/read/28066710/effect-of-adjunctive-perampanel-on-the-quality-of-sleep-and-daytime-somnolence-in-patients-with-epilepsy
#9
Montserrat González-Cuevas, Odile Romero, Manuel Toledo, Manuel Quintana, Roser Cambrodí, Estevo Santamarina, Maria José Jurado, Alex Ferrer, Xavier Salas-Puig
This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28066138/potentiation-of-decursinol-angelate-on-pentobarbital-induced-sleeping-behaviors-via-the-activation-of-gabaa-ergic-systems-in-rodents
#10
Jae Hoon Woo, Tae-Woo Ha, Jae-Seon Kang, Jin Tae Hong, Ki-Wan Oh
Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28064405/a-systematic-review-of-circadian-function-chronotype-and-chronotherapy-in-attention-deficit-hyperactivity-disorder
#11
REVIEW
Andrew N Coogan, Niall M McGowan
Reports of sleep disturbances in attention deficit hyperactivity disorder (ADHD) are common in both children and adults; however, the aetiology of such disturbances is poorly understood. One potentially important mechanism which may be implicated in disrupted sleep in ADHD is the circadian CLOCK, a known key regulator of the sleep/wake cycle. In this systematic review, we analyse the evidence for circadian rhythm changes associated with ADHD, as well as assessing evidence for therapeutic approaches involving the circadian CLOCK in ADHD...
January 7, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28063234/hadza-sleep-biology-evidence-for-flexible-sleep-wake-patterns-in-hunter-gatherers
#12
David R Samson, Alyssa N Crittenden, Ibrahim A Mabulla, Audax Z P Mabulla, Charles L Nunn
OBJECTIVES: Cross-cultural sleep research is critical to deciphering whether modern sleep expression is the product of recent selective pressures, or an example of evolutionary mismatch to ancestral sleep ecology. We worked with the Hadza, an equatorial, hunter-gatherer community in Tanzania, to better understand ancestral sleep patterns and to test hypotheses related to sleep segmentation. METHODS: We used actigraphy to analyze sleep-wake patterns in thirty-three volunteers for a total of 393 days...
January 7, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28050973/behavioral-state-classification-in-epileptic-brain-using-intracranial-electrophysiology
#13
Vaclav Kremen, Juliano Duque, Benjamin Brinkmann, Brent Berry, Michal Kucewicz, Fatemeh Khadjevand, Jamie Van Gompel, Squire Stead, Erik St Louis, Gregory A Worrell
OBJECTIVE: Automated behavioral state classification can benefit next generation implantable epilepsy devices. In this study we explored the feasibility of automated awake (AW) and slow wave sleep (SWS) classification using wide bandwidth intracranial EEG (iEEG) in patients undergoing evaluation for epilepsy surgery. APPROACH: Data from seven patients (age 34+/-12, 4 women, 5 right handed) who underwent intracranial depth electrode implantation for iEEG monitoring were included...
January 4, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28049647/regulating-the-suprachiasmatic-nucleus-scn-circadian-clockwork-interplay-between-cell-autonomous-and-circuit-level-mechanisms
#14
REVIEW
Erik D Herzog, Tracey Hermanstyne, Nicola J Smyllie, Michael H Hastings
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous transcription-based clockwork but, in turn, circuit-level interactions synchronize the 20,000 or so SCN neurons into a robust and coherent daily timer. Synchronization requires neuropeptide signaling, regulated by a reciprocal interdependence between the molecular clockwork and rhythmic electrical activity, which in turn depends on a daytime Na(+) drive and nighttime K(+) drag...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28045131/latitude-affects-morningness-eveningness-evidence-for-the-environment-hypothesis-based-on-a-systematic-review
#15
Christoph Randler, Arash Rahafar
Morningness-eveningness (M/E) is an individual trait related to a person's sleep-wake cycle and preference for morning or evening hours. The "environment hypothesis" suggests that M/E is dependent on environmental factors, such as latitude, mean average temperature and photoperiod. We here analyzed a large number of datasets to assess this effect based on a systematic review. Data were from a total of 87 datasets and 35,589 individuals based on 28 countries. Partial correlations correcting for age revealed significant relationships between M/E and latitude, mean yearly temperature, photoperiod and sunset...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039375/cholinergic-glutamatergic-and-gabaergic-neurons-of-the-ppt-have-distinct-effects-on-sleep-wake-behavior-in-mice
#16
Daniel Kroeger, Loris L Ferrari, Gaetan Petit, Carrie E Mahoney, Patrick M Fuller, Elda Arrigoni, Thomas E Scammell
: The pedunculopontine tegmental nucleus (PPT) has long been implicated in the regulation of cortical activity and behavioral states, including rapid eye movement (REM) sleep. For example, electrical stimulation of the PPT region during sleep leads to rapid awakening, whereas lesions of the PPT in cats reduce REM sleep. Though these effects have been linked with the activity of cholinergic PPT neurons, the PPT also includes intermingled glutamatergic and GABAergic cell populations, and the precise roles of cholinergic, glutamatergic and GABAergic PPT cell groups in regulating cortical activity and behavioral state remains unknown...
December 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28029090/video-evidence-that-parenting-methods-predict-which-infants-develop-long-night-time-sleep-periods-by-three-months-of-age
#17
Ian St James-Roberts, Marion Roberts, Kimberly Hovish, Charlie Owen
: Aim To examine two hypotheses about the longitudinal relationship between night-time parenting behaviours in the first few postnatal weeks and infant night-time sleep-waking at five weeks, three months and six months of age in normal London home environments. BACKGROUND: Most western infants develop long night-time sleep periods by four months of age. However, around 20-30% of infants in many countries continue to sleep for short periods and cry out on waking in the night: the most common type of infant sleep behaviour problem...
December 28, 2016: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28028196/adenosine-shifts-plasticity-regimes-between-associative-and-homeostatic-by-modulating-heterosynaptic-changes
#18
Nicholas M Bannon, Marina Chistiakova, Jen-Yung Chen, Maxim Bazhenov, Maxim Volgushev
: Endogenous extracellular adenosine level fluctuates in an activity-dependent manner and with sleep-wake cycle, modulating synaptic transmission and short-term plasticity. Hebbian-type long-term plasticity introduces intrinsic positive feedback on synaptic weight changes, making them prone to runaway dynamics. We previously demonstrated that co-occurring, weight-dependent heterosynaptic plasticity can robustly prevent runaway dynamics. Here we show that at neocortical synapses in slices from rat visual cortex, adenosine modulates the weight-dependence of heterosynaptic plasticity: blockade of adenosine A1 receptors abolished weight-dependence, while increased adenosine level strengthened it...
December 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28027399/activation-of-bdnf-trkb-signaling-in-the-pedunculopontine-tegmental-nucleus-ppt-a-novel-mechanism-for-the-homeostatic-regulation-of-rem-sleep
#19
Abigail K Barnes, Richa Koul-Tiwari, Jennifer M Garner, Phillip A Geist, Subimal Datta
REM sleep dysregulation is a symptom of many neuropsychiatric disorders, yet the mechanisms of REM sleep homeostatic regulation are not fully understood. We have shown that, after REM sleep deprivation, the pedunculopontine tegmental nucleus (PPT) plays a critical role in the generation of recovery REM sleep. In the present study, we used multidisciplinary techniques to show a causal relationship between BDNF-TrkB signaling in the PPT and the development of REM sleep homeostatic drive. Rats were randomly assigned to conditions of unrestricted sleep or selective REM sleep deprivation (RSD) with PPT microinjections of vehicle control or a dose of a TrkB receptor inhibitor (2, 3, or 4 nmol K252a or 4 nmol ANA-12)...
December 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28017605/an-lhx1-regulated-transcriptional-network-controls-sleep-wake-coupling-and-thermal-resistance-of-the-central-circadian-clockworks
#20
Joseph L Bedont, Tara A LeGates, Ethan Buhr, Abhijith Bathini, Jonathan P Ling, Benjamin Bell, Mark N Wu, Philip C Wong, Russell N Van Gelder, Valerie Mongrain, Samer Hattar, Seth Blackshaw
The suprachiasmatic nucleus (SCN) is the central circadian clock in mammals. It is entrained by light but resistant to temperature shifts that entrain peripheral clocks [1-5]. The SCN expresses many functionally important neuropeptides, including vasoactive intestinal peptide (VIP), which drives light entrainment, synchrony, and amplitude of SCN cellular clocks and organizes circadian behavior [5-16]. The transcription factor LHX1 drives SCN Vip expression, and cellular desynchrony in Lhx1-deficient SCN largely results from Vip loss [17, 18]...
January 9, 2017: Current Biology: CB
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