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Michael Balint

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https://www.readbyqxmd.com/read/28745069/a-case-series-of-pls-patients-with-frontotemporal-dementia-and-overview-of-the-literature
#1
Bálint S de Vries, Laura M M Rustemeijer, Anneke J van der Kooi, Joost Raaphorst, Carin D Schröder, Tanja C W Nijboer, Jeroen Hendrikse, Jan H Veldink, Leonard H van den Berg, Michael A van Es
OBJECTIVE: Primary lateral sclerosis (PLS) is a rare form of motor neuron disease characterised by UMN degeneration leading to slowly progressive spasticity. Whether it is a separate disease or a subtype of ALS has been debated. In ALS comorbid frontotemporal dementia (FTD) is frequently seen (±15%). However, cognitive and behavioural changes are generally not considered to be a part of PLS. METHODS: To report the clinical findings and frequency of PLS patients that developed FTD in a referral-based cohort and provide an overview of the literature...
July 26, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28740263/a-gene-encoding-maize-caffeoyl-coa-o-methyltransferase-confers-quantitative-resistance-to-multiple-pathogens
#2
Qin Yang, Yijian He, Mercy Kabahuma, Timothy Chaya, Amy Kelly, Eli Borrego, Yang Bian, Farid El Kasmi, Li Yang, Paulo Teixeira, Judith Kolkman, Rebecca Nelson, Michael Kolomiets, Jeffery L Dangl, Randall Wisser, Jeffrey Caplan, Xu Li, Nick Lauter, Peter Balint-Kurti
Alleles that confer multiple disease resistance (MDR) are valuable in crop improvement, although the molecular mechanisms underlying their functions remain largely unknown. A quantitative trait locus, qMdr9.02, associated with resistance to three important foliar maize diseases-southern leaf blight, gray leaf spot and northern leaf blight-has been identified on maize chromosome 9. Through fine-mapping, association analysis, expression analysis, insertional mutagenesis and transgenic validation, we demonstrate that ZmCCoAOMT2, which encodes a caffeoyl-CoA O-methyltransferase associated with the phenylpropanoid pathway and lignin production, is the gene within qMdr9...
July 24, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28716112/psychosocial-interventions-for-managing-occupational-stress-and-burnout-among-medical-doctors-a-systematic-review
#3
Bonnie A Clough, Sonja March, Raymond J Chan, Leanne M Casey, Rachel Phillips, Michael J Ireland
BACKGROUND: Occupational stress and burnout are highly prevalent among medical doctors and can have adverse effects on patient, doctor, and organisational outcomes. The purpose of the current study was to review and evaluate evidence on psychosocial interventions aimed at reducing occupational stress and burnout among medical doctors. METHOD: A systematic review was conducted for original research articles reporting on psychosocial interventions targeting occupational stress or burnout among medical doctors, published in the English language, and with data collected at a minimum of two time points...
July 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28708356/-what-remains-of-our-balints
#4
Régis Marion-Veyron, Konstantinos Tzartzas, Michael Saraga
In addition to providing psychiatric care to patients with somatic diseases, liaison psychiatry plays a role in the teaching of the relational aspects of medical practice. This series of three articles offers a critical reflection on this topic and examples of educational programs developed at Lausanne University Hospital. In the Department of Ambulatory Care and Community Medicine, an intervention inspired by Balint groups offers to residents in general internal medicine the possibility of working through their clinical experiences and their evolving professional identity...
February 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28358300/localizing-order-to-boost-signaling
#5
Štefan Bálint, Michael L Dustin
B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases.
March 30, 2017: ELife
https://www.readbyqxmd.com/read/28356339/nicotinamide-phosphoribosyltransferase-in-smooth-muscle-cells-maintains-genome-integrity-resists-aortic-medial-degeneration-and-is-suppressed-in-human-thoracic-aortic-aneurysm-disease
#6
Alanna Watson, Zengxuan Nong, Hao Yin, Caroline O'Neil, Stephanie Fox, Brittany Balint, Linrui Guo, Oberdan Leo, Michael W A Chu, Robert Gros, J Geoffrey Pickering
RATIONALE: The thoracic aortic wall can degenerate over time with catastrophic consequences. Vascular smooth muscle cells (SMCs) can resist and repair artery damage, but their capacities decline with age and stress. Recently, cellular production of nicotinamide adenine dinucleotide (NAD(+)) via nicotinamide phosphoribosyltransferase (Nampt) has emerged as a mediator of cell vitality. However, a role for Nampt in aortic SMCs in vivo is unknown. OBJECTIVES: To determine whether a Nampt-NAD(+) control system exists within the aortic media and is required for aortic health...
June 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28289091/membrane-nanoclusters-of-fc%C3%AE-ri-segregate-from-inhibitory-sirp%C3%AE-upon-activation-of-human-macrophages
#7
Filipa B Lopes, Štefan Bálint, Salvatore Valvo, James H Felce, Edith M Hessel, Michael L Dustin, Daniel M Davis
Signal integration between activating Fc receptors and inhibitory signal regulatory protein α (SIRPα) controls macrophage phagocytosis. Here, using dual-color direct stochastic optical reconstruction microscopy, we report that Fcγ receptor I (FcγRI), FcγRII, and SIRPα are not homogeneously distributed at macrophage surfaces but are organized in discrete nanoclusters, with a mean radius of 71 ± 11 nm, 60 ± 6 nm, and 48 ± 3 nm, respectively. Nanoclusters of FcγRI, but not FcγRII, are constitutively associated with nanoclusters of SIRPα, within 62 ± 5 nm, mediated by the actin cytoskeleton...
April 3, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28236445/the-heidenhain-variant-of-creutzfeldt-jakob-disease-and-concomitant-tau-pathology-a-case-report
#8
Edvard Ehler, Michael Pipka, Alena Meleková, Petra Mandysová, Silvie Johanidesová, Radoslav Matěj, Robert Rusina
The Heidenhain form of Creutzfeldt-Jakob disease (CJD) is a rare CJD variant with predominantly visual symptoms in the early stages. Clinical manifestations of metamorphopsia, hemianopia and Balint's syndrome correlate with the involvement of the posterior cortical regions. A 71-year old healthy and very active man was admitted because of impaired visual acuity, hemianopia, and gait disturbance progressing over one week. MRI found typical cortical hyperintensities in the occipital regions while rhythm slowing and sharp waves were seen in the occipital regions on EEG...
March 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28176810/extinctions-genetic-erosion-and-conservation-options-for-the-black-rhinoceros-diceros-bicornis
#9
Yoshan Moodley, Isa-Rita M Russo, Desiré L Dalton, Antoinette Kotzé, Shadrack Muya, Patricia Haubensak, Boglárka Bálint, Gopi K Munimanda, Caroline Deimel, Andrea Setzer, Kara Dicks, Barbara Herzig-Straschil, Daniela C Kalthoff, Hans R Siegismund, Jan Robovský, Paul O'Donoghue, Michael W Bruford
The black rhinoceros is again on the verge of extinction due to unsustainable poaching in its native range. Despite a wide historic distribution, the black rhinoceros was traditionally thought of as depauperate in genetic variation, and with very little known about its evolutionary history. This knowledge gap has hampered conservation efforts because hunting has dramatically reduced the species' once continuous distribution, leaving five surviving gene pools of unknown genetic affinity. Here we examined the range-wide genetic structure of historic and modern populations using the largest and most geographically representative sample of black rhinoceroses ever assembled...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28174322/4d-microvascular-analysis-reveals-that-regenerative-angiogenesis-in-ischemic-muscle-produces-a-flawed-microcirculation
#10
John-Michael Arpino, Zengxuan Nong, Fuyan Li, Hao Yin, Nour W Ghonaim, Stephanie Milkovich, Brittany Balint, Caroline O'Neil, Graham M Fraser, Daniel Goldman, Christopher G Ellis, J G Pickering
RATIONALE: Angiogenesis occurs following ischemic injury to skeletal muscle and enhancing this response has been a therapeutic goal. However, to appropriately deliver oxygen, a precisely organized and exquisitely responsive microcirculation must form. Whether these network attributes exist in a regenerated microcirculation is unknown and methodologies for answering this have been lacking. OBJECTIVE: To develop 4D methodologies for elucidating microarchitecture and function of the reconstructed microcirculation in skeletal muscle...
February 7, 2017: Circulation Research
https://www.readbyqxmd.com/read/28077850/reading-michael-balint-a-pragmatic-clinician-by-helene-oppenheim-gluckman-routledge-new-york-2015-102pp
#11
Mark Finn
No abstract text is available yet for this article.
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/27923796/characterization-of-the-changes-in-cardiac-structure-and-function-in-mice-treated-with-anthracyclines-using-serial-cardiac-magnetic-resonance-imaging
#12
Hoshang Farhad, Pedro V Staziaki, Daniel Addison, Otavio R Coelho-Filho, Ravi V Shah, Richard N Mitchell, Balint Szilveszter, Siddique A Abbasi, Raymond Y Kwong, Marielle Scherrer-Crosbie, Udo Hoffmann, Michael Jerosch-Herold, Tomas G Neilan
BACKGROUND: Anthracyclines are cardiotoxic; however, there are limited data characterizing the serial changes in cardiac structure and function after anthracyclines. The aim of this study was to use cardiac magnetic resonance to characterize anthracycline-induced cardiotoxicity in mice. METHODS AND RESULTS: This was a longitudinal cardiac magnetic resonance and histological study of 45 wild-type male mice randomized to doxorubicin (n=30, 5 mg/kg of doxorubicin/week for 5 weeks) or placebo (n=15)...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27898757/expanding-maize-genetic-resources-with-predomestication-alleles-maize-teosinte-introgression-populations
#13
Zhengbin Liu, Jason Cook, Susan Melia-Hancock, Katherine Guill, Christopher Bottoms, Arturo Garcia, Oliver Ott, Rebecca Nelson, Jill Recker, Peter Balint-Kurti, Sara Larsson, Nicholas Lepak, Ed Buckler, Loren Trimble, William Tracy, Michael D McMullen, Sherry A Flint-Garcia
Teosinte ( subsp. H. H. Iltis & Doebley) has greater genetic diversity than maize inbreds and landraces ( subsp. ). There are, however, limited genetic resources to efficiently evaluate and tap this diversity. To broaden resources for genetic diversity studies in maize, we developed and evaluated 928 near-isogenic introgression lines (NILs) from 10 teosinte accessions in the B73 background. Joint linkage analysis of the 10 introgression populations identified several large-effect quantitative trait loci (QTL) for days to anthesis (DTA), kernel row number (KRN), and 50-kernel weight (Wt50k)...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27765949/reading-michael-balint-a-pragmatic-clinician-by-helene-oppenheim-gluckman-routledge-new-york-2015-102pp
#14
Mark Finn
No abstract text is available yet for this article.
October 20, 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/27679736/novel-insights-into-the-polycythemia-paraganglioma-somatostatinoma-syndrome
#15
Roland Därr, Joan Nambuba, Jaydira Del Rivero, Ingo Janssen, Maria Merino, Milena Todorovic, Bela Balint, Ivana Jochmanova, Josef T Prchal, Ronald M Lechan, Arthur S Tischler, Vera Popovic, Dragana Miljic, Karen T Adams, F Ryan Prall, Alexander Ling, Meredith R Golomb, Michael Ferguson, Naris Nilubol, Clara C Chen, Emily Chew, David Taïeb, Constantine A Stratakis, Tito Fojo, Chunzhang Yang, Electron Kebebew, Zhengping Zhuang, Karel Pacak
Worldwide, the syndromes of paraganglioma (PGL), somatostatinoma (SOM) and early childhood polycythemia are described in only a few patients with somatic mutations in the hypoxia-inducible factor 2 alpha (HIF2A). This study provides detailed information about the clinical aspects and course of 7 patients with this syndrome and brings into perspective these experiences with the pertinent literature. Six females and one male presented at a median age of 28 years (range 11-46). Two were found to have HIF2A somatic mosaicism...
December 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27342138/semiautomated-confocal-imaging-of-fungal-pathogenesis-on-plants-microscopic-analysis-of-macroscopic-specimens
#16
Katharine R Minker, Meredith L Biedrzycki, Abhishek Kolagunda, Stephen Rhein, Fabiano J Perina, Samuel S Jacobs, Michael Moore, Tiffany M Jamann, Qin Yang, Rebecca Nelson, Peter Balint-Kurti, Chandra Kambhamettu, Randall J Wisser, Jeffrey L Caplan
The study of phenotypic variation in plant pathogenesis provides fundamental information about the nature of disease resistance. Cellular mechanisms that alter pathogenesis can be elucidated with confocal microscopy; however, systematic phenotyping platforms-from sample processing to image analysis-to investigate this do not exist. We have developed a platform for 3D phenotyping of cellular features underlying variation in disease development by fluorescence-specific resolution of host and pathogen interactions across time (4D)...
June 25, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27277894/physical-activity-in-european-adolescents-and-associations-with-anxiety-depression-and-well-being
#17
Elaine M McMahon, Paul Corcoran, Grace O'Regan, Helen Keeley, Mary Cannon, Vladimir Carli, Camilla Wasserman, Gergö Hadlaczky, Marco Sarchiapone, Alan Apter, Judit Balazs, Maria Balint, Julio Bobes, Romuald Brunner, Doina Cozman, Christian Haring, Miriam Iosue, Michael Kaess, Jean-Pierre Kahn, Bogdan Nemes, Tina Podlogar, Vita Poštuvan, Pilar Sáiz, Merike Sisask, Alexandra Tubiana, Peeter Värnik, Christina W Hoven, Danuta Wasserman
In this cross-sectional study, physical activity, sport participation and associations with well-being, anxiety and depressive symptoms were examined in a large representative sample of European adolescents. A school-based survey was completed by 11,110 adolescents from ten European countries who took part in the SEYLE (Saving and Empowering Young Lives in Europe) study. The questionnaire included items assessing physical activity, sport participation and validated instruments assessing well-being (WHO-5), depressive symptoms (BDI-II) and anxiety (SAS)...
January 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27189777/automated-integer-programming-based-separation-of-arteries-and-veins-from-thoracic-ct-images
#18
Christian Payer, Michael Pienn, Zoltán Bálint, Alexander Shekhovtsov, Emina Talakic, Eszter Nagy, Andrea Olschewski, Horst Olschewski, Martin Urschler
Automated computer-aided analysis of lung vessels has shown to yield promising results for non-invasive diagnosis of lung diseases. To detect vascular changes which affect pulmonary arteries and veins differently, both compartments need to be identified. We present a novel, fully automatic method that separates arteries and veins in thoracic computed tomography images, by combining local as well as global properties of pulmonary vessels. We split the problem into two parts: the extraction of multiple distinct vessel subtrees, and their subsequent labeling into arteries and veins...
May 6, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27150584/systematic-analysis-of-somatic-mutations-driving-cancer-uncovering-functional-protein-regions-in-disease-development
#19
Bálint Mészáros, András Zeke, Attila Reményi, István Simon, Zsuzsanna Dosztányi
BACKGROUND: Recent advances in sequencing technologies enable the large-scale identification of genes that are affected by various genetic alterations in cancer. However, understanding tumor development requires insights into how these changes cause altered protein function and impaired network regulation in general and/or in specific cancer types. RESULTS: In this work we present a novel method called iSiMPRe that identifies regions that are significantly enriched in somatic mutations and short in-frame insertions or deletions (indels)...
2016: Biology Direct
https://www.readbyqxmd.com/read/27145382/cancer-stem-cell-secreted-macrophage-migration-inhibitory-factor-stimulates-myeloid-derived-suppressor-cell-function-and-facilitates-glioblastoma-immune-evasion
#20
Balint Otvos, Daniel J Silver, Erin E Mulkearns-Hubert, Alvaro G Alvarado, Soumya M Turaga, Mia D Sorensen, Patricia Rayman, William A Flavahan, James S Hale, Kevin Stoltz, Maksim Sinyuk, Qiulian Wu, Awad Jarrar, Sung-Hak Kim, Paul L Fox, Ichiro Nakano, Jeremy N Rich, Richard M Ransohoff, James Finke, Bjarne W Kristensen, Michael A Vogelbaum, Justin D Lathia
Shifting the balance away from tumor-mediated immune suppression toward tumor immune rejection is the conceptual foundation for a variety of immunotherapy efforts currently being tested. These efforts largely focus on activating antitumor immune responses but are confounded by multiple immune cell populations, including myeloid-derived suppressor cells (MDSCs), which serve to suppress immune system function. We have identified immune-suppressive MDSCs in the brains of GBM patients and found that they were in close proximity to self-renewing cancer stem cells (CSCs)...
August 2016: Stem Cells
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