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Michael Balint

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https://www.readbyqxmd.com/read/27898757/expanding-maize-genetic-resources-with-predomestication-alleles-maize-teosinte-introgression-populations
#1
Zhengbin Liu, Jason Cook, Susan Melia-Hancock, Katherine Guill, Christopher Bottoms, Arturo Garcia, Oliver Ott, Rebecca Nelson, Jill Recker, Peter Balint-Kurti, Sara Larsson, Nicholas Lepak, Ed Buckler, Loren Trimble, William Tracy, Michael D McMullen, Sherry A Flint-Garcia
Teosinte ( subsp. H. H. Iltis & Doebley) has greater genetic diversity than maize inbreds and landraces ( subsp. ). There are, however, limited genetic resources to efficiently evaluate and tap this diversity. To broaden resources for genetic diversity studies in maize, we developed and evaluated 928 near-isogenic introgression lines (NILs) from 10 teosinte accessions in the B73 background. Joint linkage analysis of the 10 introgression populations identified several large-effect quantitative trait loci (QTL) for days to anthesis (DTA), kernel row number (KRN), and 50-kernel weight (Wt50k)...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27765949/reading-michael-balint-a-pragmatic-clinician-by-helene-oppenheim-gluckman-routledge-new-york-2015-102pp
#2
Mark Finn
No abstract text is available yet for this article.
October 20, 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/27679736/novel-insights-into-the-polycythemia-paraganglioma-somatostatinoma-syndrome
#3
Roland Därr, Joan Nambuba, Jaydira Del Rivero, Ingo Janssen, Maria Merino, Milena Todorovic, Bela Balint, Ivana Jochmanova, Josef T Prchal, Ronald M Lechan, Arthur S Tischler, Vera Popovic, Dragana Miljic, Karen T Adams, F Ryan Prall, Alexander Ling, Meredith R Golomb, Michael Ferguson, Naris Nilubol, Clara C Chen, Emily Chew, David Taïeb, Constantine A Stratakis, Tito Fojo, Chunzhang Yang, Electron Kebebew, Zhengping Zhuang, Karel Pacak
Worldwide, the syndromes of paraganglioma (PGL), somatostatinoma (SOM) and early childhood polycythemia are described in only a few patients with somatic mutations in the hypoxia-inducible factor 2 alpha (HIF2A). This study provides detailed information about the clinical aspects and course of 7 patients with this syndrome and brings into perspective these experiences with the pertinent literature. Six females and one male presented at a median age of 28 years (range 11-46). Two were found to have HIF2A somatic mosaicism...
December 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27342138/semiautomated-confocal-imaging-of-fungal-pathogenesis-on-plants-microscopic-analysis-of-macroscopic-specimens
#4
Katharine R Minker, Meredith L Biedrzycki, Abhishek Kolagunda, Stephen Rhein, Fabiano J Perina, Samuel S Jacobs, Michael Moore, Tiffany M Jamann, Qin Yang, Rebecca Nelson, Peter Balint-Kurti, Chandra Kambhamettu, Randall J Wisser, Jeffrey L Caplan
The study of phenotypic variation in plant pathogenesis provides fundamental information about the nature of disease resistance. Cellular mechanisms that alter pathogenesis can be elucidated with confocal microscopy; however, systematic phenotyping platforms-from sample processing to image analysis-to investigate this do not exist. We have developed a platform for 3D phenotyping of cellular features underlying variation in disease development by fluorescence-specific resolution of host and pathogen interactions across time (4D)...
June 25, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27277894/physical-activity-in-european-adolescents-and-associations-with-anxiety-depression-and-well-being
#5
Elaine M McMahon, Paul Corcoran, Grace O'Regan, Helen Keeley, Mary Cannon, Vladimir Carli, Camilla Wasserman, Gergö Hadlaczky, Marco Sarchiapone, Alan Apter, Judit Balazs, Maria Balint, Julio Bobes, Romuald Brunner, Doina Cozman, Christian Haring, Miriam Iosue, Michael Kaess, Jean-Pierre Kahn, Bogdan Nemes, Tina Podlogar, Vita Poštuvan, Pilar Sáiz, Merike Sisask, Alexandra Tubiana, Peeter Värnik, Christina W Hoven, Danuta Wasserman
In this cross-sectional study, physical activity, sport participation and associations with well-being, anxiety and depressive symptoms were examined in a large representative sample of European adolescents. A school-based survey was completed by 11,110 adolescents from ten European countries who took part in the SEYLE (Saving and Empowering Young Lives in Europe) study. The questionnaire included items assessing physical activity, sport participation and validated instruments assessing well-being (WHO-5), depressive symptoms (BDI-II) and anxiety (SAS)...
June 9, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27189777/automated-integer-programming-based-separation-of-arteries-and-veins-from-thoracic-ct-images
#6
Christian Payer, Michael Pienn, Zoltán Bálint, Alexander Shekhovtsov, Emina Talakic, Eszter Nagy, Andrea Olschewski, Horst Olschewski, Martin Urschler
Automated computer-aided analysis of lung vessels has shown to yield promising results for non-invasive diagnosis of lung diseases. To detect vascular changes which affect pulmonary arteries and veins differently, both compartments need to be identified. We present a novel, fully automatic method that separates arteries and veins in thoracic computed tomography images, by combining local as well as global properties of pulmonary vessels. We split the problem into two parts: the extraction of multiple distinct vessel subtrees, and their subsequent labeling into arteries and veins...
May 6, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27150584/systematic-analysis-of-somatic-mutations-driving-cancer-uncovering-functional-protein-regions-in-disease-development
#7
Bálint Mészáros, András Zeke, Attila Reményi, István Simon, Zsuzsanna Dosztányi
BACKGROUND: Recent advances in sequencing technologies enable the large-scale identification of genes that are affected by various genetic alterations in cancer. However, understanding tumor development requires insights into how these changes cause altered protein function and impaired network regulation in general and/or in specific cancer types. RESULTS: In this work we present a novel method called iSiMPRe that identifies regions that are significantly enriched in somatic mutations and short in-frame insertions or deletions (indels)...
2016: Biology Direct
https://www.readbyqxmd.com/read/27145382/cancer-stem-cell-secreted-macrophage-migration-inhibitory-factor-stimulates-myeloid-derived-suppressor-cell-function-and-facilitates-glioblastoma-immune-evasion
#8
Balint Otvos, Daniel J Silver, Erin E Mulkearns-Hubert, Alvaro G Alvarado, Soumya M Turaga, Mia D Sorensen, Patricia Rayman, William A Flavahan, James S Hale, Kevin Stoltz, Maksim Sinyuk, Qiulian Wu, Awad Jarrar, Sung-Hak Kim, Paul L Fox, Ichiro Nakano, Jeremy N Rich, Richard M Ransohoff, James Finke, Bjarne W Kristensen, Michael A Vogelbaum, Justin D Lathia
Shifting the balance away from tumor-mediated immune suppression toward tumor immune rejection is the conceptual foundation for a variety of immunotherapy efforts currently being tested. These efforts largely focus on activating antitumor immune responses but are confounded by multiple immune cell populations, including myeloid-derived suppressor cells (MDSCs), which serve to suppress immune system function. We have identified immune-suppressive MDSCs in the brains of GBM patients and found that they were in close proximity to self-renewing cancer stem cells (CSCs)...
August 2016: Stem Cells
https://www.readbyqxmd.com/read/27025294/a-comparative-study-of-the-in-vitro-permeation-of-ibuprofen-in-mammalian-skin-the-pampa-model-and-silicone-membrane
#9
Lin Luo, Avnish Patel, Balint Sinko, Michael Bell, Judata Wibawa, Jonathan Hadgraft, Majella E Lane
Human skin remains the membrane of choice when conducting in vitro studies to determine dermal penetration of active pharmaceutical ingredients or xenobiotics. However there are ethical and safety issues associated with obtaining human tissue. For these reasons synthetic membranes, cell culture models or in silico predictive algorithms have been researched intensively as alternative approaches to predict dermal exposure in man. Porcine skin has also been recommended as an acceptable surrogate for topical or transdermal delivery research...
May 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26786007/here-there-and-everywhere-higher-visual-function-and-the-dorsal-visual-stream
#10
REVIEW
Sarah Anne Cooper, Michael O'Sullivan
The dorsal visual stream, often referred to as the 'where' stream, represents the pathway taken by visual information from the primary visual cortex to the posterior parietal lobe and onwards. It partners the ventral or 'what' stream, the subject of a previous review and largely a temporal-based system. Here, we consider the dorsal stream disorders of perception (simultanagnosia, akinetopsia) along with their consequences on action (eg, optic ataxia and oculomotor apraxia, along with Balint's syndrome). The role of the dorsal stream in blindsight and hemispatial neglect is also considered...
June 2016: Practical Neurology
https://www.readbyqxmd.com/read/26374689/coordination-of-self-renewal-in-glioblastoma-by-integration-of-adhesion-and-microrna-signaling
#11
Alvaro G Alvarado, Soumya M Turaga, Pratheesh Sathyan, Erin E Mulkearns-Hubert, Balint Otvos, Daniel J Silver, James S Hale, William A Flavahan, Pascal O Zinn, Maksim Sinyuk, Meizhang Li, Maheedhara R Guda, Kiran K Velpula, Andrew J Tsung, Ichiro Nakano, Michael A Vogelbaum, Sadhan Majumder, Jeremy N Rich, Justin D Lathia
BACKGROUND: Cancer stem cells (CSCs) provide an additional layer of complexity for tumor models and targets for therapeutic development. The balance between CSC self-renewal and differentiation is driven by niche components including adhesion, which is a hallmark of stemness. While studies have demonstrated that the reduction of adhesion molecules, such as integrins and junctional adhesion molecule-A (JAM-A), decreases CSC maintenance. The molecular circuitry underlying these interactions has yet to be resolved...
May 2016: Neuro-oncology
https://www.readbyqxmd.com/read/26359488/2015-recommendations-for-the-management-of-polymyalgia-rheumatica-a-european-league-against-rheumatism-american-college-of-rheumatology-collaborative-initiative
#12
Christian Dejaco, Yogesh P Singh, Pablo Perel, Andrew Hutchings, Dario Camellino, Sarah Mackie, Andy Abril, Artur Bachta, Peter Balint, Kevin Barraclough, Lina Bianconi, Frank Buttgereit, Steven Carsons, Daniel Ching, Maria Cid, Marco Cimmino, Andreas Diamantopoulos, William Docken, Christina Duftner, Billy Fashanu, Kate Gilbert, Pamela Hildreth, Jane Hollywood, David Jayne, Manuella Lima, Ajesh Maharaj, Christian Mallen, Victor Martinez-Taboada, Mehrdad Maz, Steven Merry, Jean Miller, Shunsuke Mori, Lorna Neill, Elisabeth Nordborg, Jennifer Nott, Hannah Padbury, Colin Pease, Carlo Salvarani, Michael Schirmer, Wolfgang Schmidt, Robert Spiera, David Tronnier, Alexandre Wagner, Madeline Whitlock, Eric L Matteson, Bhaskar Dasgupta
Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) recommendations for the management of PMR. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology as a framework for the project. Accordingly, the direction and strength of the recommendations are based on the quality of evidence, the balance between desirable and undesirable effects, patients' and clinicians' values and preferences, and resource use...
October 2015: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26352874/2015-recommendations-for-the-management-of-polymyalgia-rheumatica-a-european-league-against-rheumatism-american-college-of-rheumatology-collaborative-initiative
#13
Christian Dejaco, Yogesh P Singh, Pablo Perel, Andrew Hutchings, Dario Camellino, Sarah Mackie, Andy Abril, Artur Bachta, Peter Balint, Kevin Barraclough, Lina Bianconi, Frank Buttgereit, Steven Carsons, Daniel Ching, Maria Cid, Marco Cimmino, Andreas Diamantopoulos, William Docken, Christina Duftner, Billy Fashanu, Kate Gilbert, Pamela Hildreth, Jane Hollywood, David Jayne, Manuella Lima, Ajesh Maharaj, Christian Mallen, Victor Martinez-Taboada, Mehrdad Maz, Steven Merry, Jean Miller, Shunsuke Mori, Lorna Neill, Elisabeth Nordborg, Jennifer Nott, Hannah Padbury, Colin Pease, Carlo Salvarani, Michael Schirmer, Wolfgang Schmidt, Robert Spiera, David Tronnier, Alexandre Wagner, Madeline Whitlock, Eric L Matteson, Bhaskar Dasgupta
Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) recommendations for the management of PMR. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology as a framework for the project. Accordingly, the direction and strength of the recommendations are based on the quality of evidence, the balance between desirable and undesirable effects, patients' and clinicians' values and preferences, and resource use...
October 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26351116/conversion-arthroplasty-of-the-hip-mid-term-results-are-good
#14
Akos Zahar, Michael B Cross, Tamas Lakatos, Jozsef Lakatos, Balint Major, Daniel Kendoff, Miklos Szendröi
The historical mid-term results of conversion total hip arthroplasty (THA) are acceptable; however, the complication rates are high. In total, 39 patients (45 hips) from 2 institutions underwent conversion THA from 1993-2006 and were retrospectively evaluated. The mean age was 48.3 years, the mean follow-up time was 8.7 years, and the mean duration arthrodesis prior to conversion THA was 18.2 years. The outcomes included operative time, blood loss, leg-length discrepancy (LLD), thigh circumference, Harris Hip Score (HHS), complications, and radiographic evaluation...
November 2015: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/26291285/anti-dppx-encephalitis-pathogenic-effects-of-antibodies-on-gut-and-brain-neurons
#15
Johannes Piepgras, Markus Höltje, Klaus Michel, Qin Li, Carolin Otto, Christoph Drenckhahn, Christian Probst, Michael Schemann, Sven Jarius, Winfried Stöcker, Bettina Balint, Hans-Michael Meinck, Ralph Buchert, Josep Dalmau, Gudrun Ahnert-Hilger, Klemens Ruprecht
OBJECTIVE: To characterize pathogenic effects of antibodies to dipeptidyl-peptidase-like protein 6 (DPPX), a subunit of Kv4.2 potassium channels, on gut and brain neurons. METHODS: We identified a new patient with anti-DPPX encephalitis and analyzed the effects of the patient's serum and purified immunoglobulin G (IgG), and of serum of a previous patient with anti-DPPX encephalitis, on the activity of enteric neurons by voltage-sensitive dye imaging in guinea pig myenteric and human submucous plexus preparations...
September 8, 2015: Neurology
https://www.readbyqxmd.com/read/26183774/fibroblast-growth-factor-9-imparts-hierarchy-and-vasoreactivity-to-the-microcirculation-of-renal-tumors-and-suppresses-metastases
#16
Hao Yin, Matthew J Frontini, John-Michael Arpino, Zengxuan Nong, Caroline O'Neil, Yiwen Xu, Brittany Balint, Aaron D Ward, Subrata Chakrabarti, Christopher G Ellis, Robert Gros, J Geoffrey Pickering
Tumor vessel normalization has been proposed as a therapeutic paradigm. However, normal microvessels are hierarchical and vasoreactive with single file transit of red blood cells through capillaries. Such a network has not been identified in malignant tumors. We tested whether the chaotic tumor microcirculation could be reconfigured by the mesenchyme-selective growth factor, FGF9. Delivery of FGF9 to renal tumors in mice yielded microvessels that were covered by pericytes, smooth muscle cells, and a collagen-fortified basement membrane...
September 4, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25956394/extended-evaluation-of-a-phase-1-2-trial-on-dosing-safety-immunogenicity-and-overall-survival-after-immunizations-with-an-advanced-generation-ad5-e1-e2b-cea-6d-vaccine-in-late-stage-colorectal-cancer
#17
Joseph P Balint, Elizabeth S Gabitzsch, Adrian Rice, Yvette Latchman, Younong Xu, Gerald L Messerschmidt, Arvind Chaudhry, Michael A Morse, Frank R Jones
A phase 1/2 clinical trial evaluating dosing, safety, immunogenicity, and overall survival on metastatic colorectal cancer (mCRC) patients after immunotherapy with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine was performed. We report our extended observations on long-term overall survival and further immune analyses on a subset of treated patients including assessment of cytolytic T cell responses, T regulatory (Treg) to T effector (Teff) cell ratios, flow cytometry on peripheral blood mononuclear cells (PBMCs), and determination of HLA-A2 status...
August 2015: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/25767275/collectivization-of-vascular-smooth-muscle-cells-via-tgf-%C3%AE-cadherin-11-dependent-adhesive-switching
#18
COMPARATIVE STUDY
Brittany Balint, Hao Yin, Subrata Chakrabarti, Michael W A Chu, Stephen M Sims, J Geoffrey Pickering
OBJECTIVE: Smooth muscle cells (SMCs) in healthy arteries are arranged as a collective. However, in diseased arteries, SMCs commonly exist as individual cells, unconnected to each other. The purpose of this study was to elucidate the events that enable individualized SMCs to enter into a stable and interacting cell collective. APPROACH AND RESULTS: Human SMCs stimulated to undergo programmed collectivization were tracked by time-lapse microscopy. We uncovered a switch in the behavior of contacting SMCs from semiautonomous motility to cell-cell adherence...
May 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/25616050/full-genome-sequence-analysis-of-a-wild-non-mlv-related-type-2-hungarian-prrsv-variant-isolated-in-europe
#19
Gyula Balka, Xiong Wang, Ferenc Olasz, Ádám Bálint, István Kiss, Krisztián Bányai, Miklós Rusvai, Tomasz Stadejek, Douglas Marthaler, Michael P Murtaugh, Zoltán Zádori
Porcine reproductive and respiratory syndrome virus (PRRSV) is a widespread pathogen of pigs causing significant economic losses to the swine industry. The expanding diversity of PRRSV strains makes the diagnosis, control and eradication of the disease more and more difficult. In the present study, the authors report the full genome sequencing of a type 2 PRRSV strain isolated from piglet carcasses in Hungary. Next generation sequencing was used to determine the complete genome sequence of the isolate (PRRSV-2/Hungary/102/2012)...
March 16, 2015: Virus Research
https://www.readbyqxmd.com/read/25599198/tumor-progression-in-patients-receiving-adjuvant-whole-brain-radiotherapy-vs-localized-radiotherapy-after-surgical-resection-of-brain-metastases
#20
Jason Hsieh, Paul Elson, Balint Otvos, Jonathan Rose, Christopher Loftus, Gazanfar Rahmathulla, Lilyana Angelov, Gene H Barnett, Robert J Weil, Michael A Vogelbaum
BACKGROUND: Surgery followed by adjuvant radiotherapy is a well-established treatment paradigm for brain metastases. OBJECTIVE: To examine the effect of postsurgical whole-brain radiotherapy (WBRT) or localized radiotherapy (LRT), including stereotactic radiosurgery and intraoperative radiotherapy, on the rate of recurrence both local and distal to the resection site in the treatment of brain metastases. METHODS: We retrospectively identified patients who underwent surgery for brain metastasis at the Cleveland Clinic between 2004 and 2012...
April 2015: Neurosurgery
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