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Amphetamine typed stimulants

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https://www.readbyqxmd.com/read/29453444/positive-regulation-of-raphe-serotonin-neurons-by-serotonin-2b-receptors
#1
Arnauld Belmer, Emily Quentin, Silvina L Diaz, Bruno P Guiard, Sebastian P Fernandez, Stéphane Doly, Sophie M Banas, Pothitos M Pitychoutis, Imane Moutkine, Aude Muzerelle, Anna Tchenio, Anne Roumier, Manuel Mameli, Luc Maroteaux
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT 2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT 2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT 2B receptors directly and positively regulate raphe serotonin neuron activity...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29429705/synthesis-of-novel-sonocatalyst-er3-yalo3-nb2o5-and-its-application-for-sonocatalytic-degradation-of-methamphetamine-hydrochloride
#2
Chunsheng Wei, Kuiyu Yi, Guangsheng Sun, Jun Wang
The composited sonocatalyst Er3+:YAlO3/Nb2O5 was prepared by ultrasonic dispersion and high temperature calcinations method. The microstructure of Er3+:YAlO3 was prepared via sol-gel method and Nb2O5 was prepared by hydrothermal method. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), ultraviolet-visible (UV-vis) spectra and photoluminescence (PL) spectra, respectively. The sonocatalytic decomposition activity of composite sonocatalyst Er3+:YAlO3/Nb2O5 was investigated by using ultrasound as sound source and methamphetamine hydrochloride as the target degradation product...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29406033/determination-and-long-term-stability-of-twenty-nine-cathinones-and-amphetamine-type-stimulants-ats-in-urine-using-gas-chromatography-mass-spectrometry
#3
Khalid A Alsenedi, Calum Morrison
A method was developed for the screening and quantification of seven amphetamine-type stimulants (ATS) and 22 cathinones, including three metabolites, in urine with Gas Chromatography-Mass Spectrometry. This method allowed the detection and quantification of ATS and cathinones group molecules using one procedure. A study of the stability of the drug mixtures for a period of 201 days in human urine samples under three different conditions has been carried. The ATS and cathinones include amphetamine, methamphetamine, MDA, MDEA, MDMA, PMA, PMMA, cathinone, methcathinone, 3'-position-substituted, ring-substituted, methylenedioxy-substituted, N-alkyl-substituted and pyrrolidinyl-substituted...
February 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29406017/examining-the-effectiveness-of-acetylcholinesterase-inhibitors-and-stimulant-based-medications-for-cognitive-dysfunction-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#4
REVIEW
Jack Cotter, Nils Muhlert, Anahita Talwar, Kiri Granger
We sought to examine the effectiveness of acetylcholinesterase inhibitors (AChEIs) and stimulant-based medications for improving cognitive performance in patients with multiple sclerosis (MS). An electronic database search was conducted on 25th March 2017. Eligible studies were double-blind, randomised, placebo-controlled trials that examined the efficacy of compounds that act primarily as AChEIs or stimulants (administered daily for ≥1 week) on cognitive outcome measures in patients with MS. Where suitable data was reported, we generated effect sizes and corresponding 95% confidence intervals and performed meta-analyses using random-effects models to investigate the effectiveness of these drug types across cognitive domains...
March 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29364035/regulator-of-g-protein-signaling-12-modulates-the-dopamine-transporter-in-ventral-striatum-and-locomotor-responses-to-psychostimulants
#5
Joshua D Gross, Shane W Kaski, Adam B Schroer, Kimberley A Wix, David P Siderovski, Vincent Setola
Regulators of G protein signaling are proteins that accelerate the termination of effector stimulation after G protein-coupled receptor activation. Many regulators of G protein signaling proteins are highly expressed in the brain and therefore considered potential drug discovery targets for central nervous system pathologies; for example, here we show that RGS12 is highly expressed in microdissected mouse ventral striatum. Given a role for the ventral striatum in psychostimulant-induced locomotor activity, we tested whether Rgs12 genetic ablation affected behavioral responses to amphetamine and cocaine...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29298737/a-feasible-model-for-early-intervention-for-high-risk-substance-use-in-the-emergency-department-setting
#6
Rebecca Howard, Stephanie Fry, Andrew Chan, Brigid Ryan, Yvonne Bonomo
Objective In response to escalating alcohol and other drug (AOD)-related emergency department (ED) presentations, a tertiary Melbourne hospital embedded experienced AOD clinical nurse consultants in the ED on weekends to trial a model for screening, assessment and brief intervention (BI). The aim of the present study was to evaluate the relative contributions of AOD to ED presentations and to pilot a BI model.Methods Using a customised AOD screening tool and a framework for proactive case finding, screened participants were offered a comprehensive AOD assessment and BI in the ED...
January 4, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29175556/rapid-and-simple-procedure-for-the-determination-of-cathinones-amphetamine-like-stimulants-and-other-new-psychoactive-substances-in-blood-and-urine-by-gc-ms
#7
Gilbert Mercieca, Sara Odoardi, Marisa Cassar, Sabina Strano Rossi
In the last few years an increasing number of new psychoactive substances (NPS), with different chemical structures (of which 37% are stimulants), have been released into the illicit drug market. Their detection and identification in biological samples is hence of great concern. The aim of this work was to develop a high-throughput and rapid method for the determination of different classes of stimulants (amphetamine-type stimulants, cathinones, phenethylamines and ketamine analogues) from blood and urine samples using GC-MS...
November 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29128711/polysubstance-use-profiles-among-electronic-dance-music-party-attendees-in-new-york-city-and-their-relation-to-use-of-new-psychoactive-substances
#8
Fermín Fernández-Calderón, Charles M Cleland, Joseph J Palamar
BACKGROUND: Electronic Dance Music (EDM) party attendees are often polysubstance users and are at high risk for use of new psychoactive substances (NPS). We sought to identify patterns of use of common illegal drugs among EDM party attendees, sociodemographic correlates, and use of NPS as a function of patterns of use of more common drugs to inform prevention and harm reduction. METHOD: Using time-space-sampling, 1045 individuals aged 18-40 were surveyed entering EDM parties in New York City...
November 4, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29063964/phytocannabinoids-modulate-emotional-memory-processing-through-interactions-with-the-ventral-hippocampus-and-mesolimbic-dopamine-system-implications-for-neuropsychiatric-pathology
#9
REVIEW
Roger Hudson, Walter Rushlow, Steven R Laviolette
Growing clinical and preclinical evidence suggests a potential role for the phytocannabinoid cannabidiol (CBD) as a pharmacotherapy for various neuropsychiatric disorders. In contrast, delta-9-tetrahydrocannabinol (THC), the primary psychoactive component in cannabis, is associated with acute and neurodevelopmental propsychotic side effects through its interaction with central cannabinoid type 1 receptors (CB1Rs). CB1R stimulation in the ventral hippocampus (VHipp) potentiates affective memory formation through inputs to the mesolimbic dopamine (DA) system, thereby altering emotional salience attribution...
October 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29051727/syvn1-an-erad-e3-ubiquitin-ligase-is-involved-in-gabaa%C3%AE-1-degradation-associated-with-methamphetamine-induced-conditioned-place-preference
#10
Dong-Liang Jiao, Yan Chen, Yao Liu, Yun-Yue Ju, Jian-Dong Long, Jiang Du, Chang-Xi Yu, Yu-Jun Wang, Min Zhao, Jing-Gen Liu
Abuse of methamphetamine (METH), a powerful addictive amphetamine-type stimulants (ATS), is becoming a global public health problem. The gamma-aminobutyric acid (GABA)ergic system plays a critical role in METH use disorders. By using rat METH conditioned place preference (CPP) model, we previously demonstrated that METH-associated rewarding memory formation was associated with the reduction of GABAAα1 expression in the dorsal straitum (Dstr), however, the underlying mechanism was unclear. In the present study, we found that METH-induced CPP formation was accompanied by a significant increase in the expression of Synovial apoptosis inhibitor 1 (SYVN1), an endoplasmic reticulum (ER)-associated degradation (ERAD) E3 ubiquitin ligase, in the Dstr...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29037791/effect-of-optogenetic-modulation-on-entopeduncular-input-affects-thalamic-discharge-and-behavior-in-an-aav2-%C3%AE-synuclein-induced-hemiparkinson-rat-model
#11
Hyeong Cheol Moon, So Yoon Won, Eung Gook Kim, Hyong Kyu Kim, Chul Bum Cho, Young Seok Park
OBJECTIVE: Neuromodulation of the globus pallidus internus(GPi) alleviates Parkinson's disease symptoms. The primate GPi is homologous to the rat entopeduncular nucleus (EP). The aim of the present study was to determine if optogenetic modulation of the EP could alter parkinsonian behavior or thalamic discharge in a hemiparkinson rat model. METHODS: We injected an adeno-associated virus type-2 expressing α-synuclein (AAV2-α-syn) into the substantia nigra pars compacta (SNc) of the right hemisphere and confirmed parkinsonian behavior using an amphetamine-induced rotation test...
October 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29029537/the-synergistic-effect-of-dual-use-of-amphetamine-type-stimulants-and-ketamine-on-drug-induced-psychotic-symptoms-in-chinese-synthetic-drug-users
#12
Xue-Bing Liu, Yao Zhang, Xu-Yi Wang, Wei Hao
The use of amphetamine-type stimulants (ATS) and ketamine is of particular clinical concern because of its associated psychotic symptoms. In Chinese clinical practice, ATS and ketamine are commonly used simultaneously, but very few studies have reported the symptom profile of users who use both drugs. This study determined whether the combined use of ATS and ketamine is associated with more psychotic symptoms than either ATS or ketamine alone. According to drug use characteristics, 375 Chinese synthetic drug users were categorized into 2 pairs of comparison groups: ATS-only (n=125) vs...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28993742/development-and-validation-of-the-amphetamine-type-stimulants-motive-questionnaire-in-a-clinical-population
#13
Daniela Thurn, Emmanuel Kuntsche, Jennifer Anna Weber, Jörg Wolstein
Approximately 35.7 million people world-wide use amphetamine-type stimulants (ATS) leading to a high demand for effective treatment. Understanding the motives behind ATS use is a necessary basis for preventive and therapeutic treatment. The objective of this study is to develop the Amphetamine-Type stimulants Motive Questionnaire (AMQ) and to confirm its construct and concurrent validity in respect to the first and the latest month of ATS use based on answers of 233 patients with ATS disorders (74.2% male; mean age: 31...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28978251/intermolecular-interactions-between-dna-and-methamphetamine-amphetamine-ecstasy-and-their-major-metabolites
#14
Arthur F V F Reis, Igor L P Gonçalves, Abel F G Neto, Alberdan S Santos, Kamil Kuca, Eugenie Nepovimova, Antonio M J C Neto
In this work we carried out a theoretical investigation regarding amphetamine-type stimulants, which can cause central nervous system degeneration, interacting with human DNA. Theseinclude amphetamine, methamphetamine,3,4-Methylenedioxymethamphetamine (also known as ecstasy), as well as their main metabolites. The studies were performed through molecular docking and molecular dynamics simulations, where molecular interactions of the receptor-ligand systems, along with their physical-chemical energies, were reported...
October 5, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28957720/application-of-gas-chromatography-tandem-mass-spectrometry-for-the-determination-of-amphetamine-type-stimulants-in-blood-and-urine
#15
Mateusz Kacper Woźniak, Marek Wiergowski, Justyna Aszyk, Paweł Kubica, Jacek Namieśnik, Marek Biziuk
Amphetamine, methamphetamine, phentermine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxy-N-ethylamphetamine (MDEA) are the most popular amphetamine-type stimulants. The use of these substances is a serious societal problem worldwide. In this study, a method based on gas chromatography-tandem mass spectrometry (GC-MS/MS) with simple and rapid liquid-liquid extraction (LLE) and derivatization was developed and validated for the simultaneous determination of the six aforementioned amphetamine derivatives in blood and urine...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28942374/toxicological-findings-in-suspected-drug-impaired-drivers-in-norway-trends-during-1990-2015
#16
Anja Valen, Stig Tore Bogstrand, Vigdis Vindenes, Hallvard Gjerde
This study describes trends in drug use among drivers suspected of driving under the influence of drugs, apprehended by the police in Norway during 1990-2015. Chromatographically determined toxicological findings in blood samples were retrospectively investigated. Drug findings above defined cut-off concentrations were considered positive; hence making the annual prevalence comparable during the 26 years studied. Blood samples from 112,348 drivers were included, of which 63% were positive for drugs; 43% had combined drug with alcohol or other drugs...
September 15, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28922649/determination-of-74-new-psychoactive-substances-in-serum-using-automated-in-line-solid-phase-extraction-liquid-chromatography-tandem-mass-spectrometry
#17
Sabrina Lehmann, Tobias Kieliba, Justus Beike, Mario Thevis, Katja Mercer-Chalmers-Bender
A detailed description is given of the development and validation of a fully automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) method capable of detecting 90 central-stimulating new psychoactive substances (NPS) and 5 conventional amphetamine-type stimulants (amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA), methamphetamine) in serum. The aim was to apply the validated method to forensic samples...
October 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28912087/endocannabinoid-mechanism-in-amphetamine-type-stimulant-use-disorders-a-short-review
#18
REVIEW
Hang Su, Min Zhao
Recent evidence shows that the endocannabinoid system is involved in amphetamine-type stimulants (ATS) use disorders. To elucidate the role of the endocannabinoid system in ATS addiction, we reviewed results of studies using cannabinoid receptor agonists, antagonists as well as knockout model. The endocannabinoid system seems to play a role in reinstatement and relapse of ATS addiction and ATS-induced psychiatric symptoms. The molecular mechanisms of this system remains unclear, the association with dopamine system in nucleus accumbens is most likely involved...
December 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28910664/the-analysis-of-132-novel-psychoactive-substances-in-human-hair-using-a-single-step-extraction-by-tandem-lc-ms
#19
Vassiliki A Boumba, Matthew Di Rago, Melissa Peka, Olaf H Drummer, Dimitri Gerostamoulos
A rapid LC-MS/MS method for the targeted screening of 132 NPS in hair is described. Drugs include cathinones and synthetic cannabinoids, as well as amphetamine-type stimulants, piperazines and other hallucinogenic compounds. This method utilizes hair pulverization in acidified methanol followed by analysis using liquid chromatography coupled with tandem MS. The limit of detection varied from 0.001 to 0.1ng/mg hair among the various analytes. The method was validated in terms of sensitivity, selectivity, repeatability and stability...
October 2017: Forensic Science International
https://www.readbyqxmd.com/read/28901213/hiv-prevalence-and-correlated-factors-of-female-sex-workers-and-male-clients-in-a-border-region-of-yunnan-province-china
#20
Jing Zhu, Rui Yuan, Dan Hu, Zhibin Zhu, Ning Wang, Bei Wang
Female sex workers (FSWs) and their male clients are vulnerable to HIV infection and serve as a bridge in HIV transmission from the high-risk population to the general, low-risk population. To examine the factors of FSWs and male clients that correlate with the prevalence of HIV infection in the Chinese-Vietnamese border region, a cross-sectional survey was conducted in 2014 in the Hekou county of the Yunnan province of China. We performed a questionnaire survey to collect data on demographics, sexual behavior, and drug use...
January 1, 2017: International Journal of STD & AIDS
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