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Amphetamine typed stimulants

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https://www.readbyqxmd.com/read/29642565/polyacrylonitrile-nanofiber-based-quartz-crystal-microbalance-for-sensitive-detection-of-safrole
#1
Aditya Rianjanu, Roto Roto, Trisna Julian, Shidiq Nur Hidayat, Ahmad Kusumaatmaja, Eko Agus Suyono, Kuwat Triyana
Safrole is the main precursor for producing the amphetamine-type stimulant (ATS) drug, N -methyl-3,4-methylenedioxyamphetamine (MDMA), also known as ecstasy. We devise a polyacrylonitrile (PAN) nanofiber-based quartz crystal microbalance (QCM) for detecting safrole. The PAN nanofibers were fabricated by direct electrospinning to modify the QCM chips. The PAN nanofiber on the QCM chips has a diameter of 240 ± 10 nm. The sensing of safrole by QCM modified with PAN nanofiber shows good reversibility and an apparent sensitivity of 4...
April 10, 2018: Sensors
https://www.readbyqxmd.com/read/29609152/experiences-of-police-contact-among-young-adult-recreational-drug-users-a-qualitative-study
#2
Ellen M Leslie, Adrian Cherney, Andrew Smirnov, Robert Kemp, Jake M Najman
BACKGROUND: While young adults who engage in recreational drug use are at increased risk of contact with police, their experiences of police contact have been largely overlooked. METHOD: In-depth qualitative interviews were conducted with 70 young adult amphetamine-type stimulant (ATS; i.e., ecstasy [MDMA] and methamphetamine) users who had experienced intensive alcohol and other drug-related police contact (e.g., being arrested, charged, or raided by police). These interviews focused on perceptions of personal experiences of alcohol and other drug-related police contact and general perceptions of police and policing and were conducted as part of a larger longitudinal study of drug use among a population-based sample of young adults from South-East Queensland, Australia...
March 30, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29573648/atomoxetine-for-amphetamine-type-stimulant-dependence-during-buprenorphine-treatment-a-randomized-controlled-trial
#3
Richard S Schottenfeld, Marek C Chawarski, Mehmet Sofuoglu, Weng-Tink Chooi, Norzarina M Zaharim, M Azhar M Yasin, Imran Ahmad, Sharifah Zubaidiah Syed Jaapar, B Kasinather Vicknasingam
BACKGROUND: Amphetamine type stimulants (ATS) use is highly prevalent and frequently co-occurs with opioid dependence in Malaysia and Asian countries. No medications have established efficacy for treating ATS use disorder. This study evaluated the safety, tolerability, and potential efficacy of atomoxetine for treating ATS use disorder. METHODS: Participants with opioid and ATS dependence (N = 69) were enrolled in a pilot, double-blind, placebo-controlled randomized clinical trial; all received buprenorphine/naloxone and behavioral counseling and were randomized to atomoxetine 80 mg daily (n = 33) or placebo (n = 33)...
March 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29554274/dibutylone-bk-dmbdb-intoxications-quantitative-confirmations-and-metabolism-in-authentic-biological-specimens
#4
Alex J Krotulski, Amanda L A Mohr, Donna M Papsun, Barry K Logan
The number of emerging novel stimulants modified based on beta-keto variations of amphetamine-like substances continues to rise. Dibutylone reports described in the medical and toxicological literature are limited, therefore little information is available in terms of quantitative confirmation or metabolism. During this study, authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver were quantitatively and qualitatively analyzed for the presence of dibutylone and butylone, with paired case history and demographic information...
March 15, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29533079/ice-in-the-outback-the-epidemiology-of-amphetamine-type-stimulant-related-hospital-admissions-and-presentations-to-the-emergency-department-in-hedland-western-australia
#5
Caitriona Monahan, Mathew Coleman
OBJECTIVES: Despite research showing higher use of amphetamine-type stimulants (ATS) in rural areas, limited research has examined the epidemiology of ATS-related presentations and admissions to remote regional centres. To determine the epidemiology of ATS-related (a) Emergency Department (ED) presentations and (b) inpatient admissions over a five-year period at the Hedland Health Campus (HHC) in remote Western Australia. METHODS: A retrospective review of medical records was conducted...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29503826/predictive-factors-of-mortality-in-acute-amphetamine-type-stimulants-poisoning-a-review-of-226-cases
#6
Mitra Rahimi, Somaieh Lookzadeh, Roxana Sadeghi, Kambiz Soltaninejad, Shahin Shadnia, Abdolkarim Pajoumand, Hossein Hassanian-Moghaddam, Nasim Zamani, Masoud Latifi-Pour
Introduction: Amphetamine type stimulants (ATS) such as amphetamine and methamphetamine (MA) are one of the most important causes of poisoning in the world. In this study we aimed to define the predictive factors of mortality in acute ATS poisoning patients. Methods: This is a retrospective cross-sectional study on all cases with acute ATS poisoning who were referred to a referral center for poisoning, Tehran, Iran, from April 2011 to March 2014. Using patients' medical records, demographic data, route of exposure, type and amount of ATS, the cause of poisoning, clinical presentations, and electrocardiogram (ECG) and laboratory findings, as well as patient's outcomes were collected and analyzed regarding the independent predictive factors of mortality...
2018: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/29501195/supras-extraction-approach-for-matrix-independent-determination-of-amphetamine-type-stimulants-by-lc-ms-ms
#7
Francesca Accioni, Diego García-Gómez, Eloy Girela, Soledad Rubio
Monitoring of amphetamine-type stimulant (ATS) confronts clinical labs with a high number of samples involving a variety of biological matrices. Liquid chromatography-tandem mass spectrometry (LC-MS/MS), routinely used for confirmation of ATS abuse, requires of laborious and matrix-dependent sample treatment methods, this increasing analysis time and cost. In this work, a universal and single-step sample treatment, based on supramolecular solvents (SUPRAS), was proposed for simplifying ATS confirmation in seven biological matrices...
May 15, 2018: Talanta
https://www.readbyqxmd.com/read/29487040/feasibility-of-a-mobile-phone-app-to-support-recovery-from-addiction-in-china-secondary-analysis-of-a-pilot-study
#8
Hui Han, Jing Ying Zhang, Yih-Ing Hser, Di Liang, Xu Li, Shan Shan Wang, Jiang Du, Min Zhao
BACKGROUND: Mobile health technologies have been found to improve the self-management of chronic diseases. However, there is limited research regarding their feasibility in supporting recovery from substance use disorders (SUDs) in China. OBJECTIVE: The objective of this study was to examine the feasibility of a mobile phone-based ecological momentary assessment (EMA) app by testing the concordance of drug use assessed by the EMA, urine testing, and a life experience timeline (LET) assessment...
February 27, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29481765/a-randomised-controlled-trial-of-a-brief-intervention-for-illicit-drug-use-linked-to-assist-screening-in-a-primary-healthcare-setting-results-from-the-australian-component-of-the-world-health-organization-phase-iii-assist-studies
#9
Rachel Humeniuk, David A L Newcombe, Victoria Dennington, Robert Ali
This report presents the findings from the Australian component of the Phase III World Health Organization (WHO) Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) randomised controlled trial investigating the effectiveness of a 5-10-min brief intervention (BI) for illicit drug use delivered in primary healthcare (PHC) settings. Participants (n=171) recruited from a South Australian PHC setting (sexual health clinic) who scored in the 'moderate risk' range on the ASSIST were randomly allocated to an intervention group or wait-list control group at baseline and were followed up 3 months later...
February 27, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29475104/distress-and-sleep-quality-in-young-amphetamine-type-stimulant-users-with-an-affective-or-psychotic-illness
#10
Jacob J Crouse, Rico S C Lee, Django White, Ahmed A Moustafa, Ian B Hickie, Daniel F Hermens
Misuse of amphetamine-type stimulant (ATS) drugs may disrupt key neurodevelopmental processes in young people and confer protracted neurocognitive and psychopathological harm. ATS users with a co-occurring psychiatric illness are typically excluded from research, reducing generalisability of findings. Accordingly, we conducted a cross-sectional examination of key clinical, sleep, socio-occupational and neurocognitive measures in current, past and never users of ATS drugs who were accessing a youth mental health service (headspace) for affective- or psychotic-spectrum illnesses...
February 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29465560/olanzapine-and-haloperidol-for-the-treatment-of-acute-symptoms-of-mental-disorders-induced-by-amphetamine-type-stimulants-a-randomized-controlled-trial
#11
Xiaobin Xue, Yun Song, Xiaojie Yu, Qiang Fan, Jiyou Tang, Xu Chen
BACKGROUND: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs). METHODS: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Clinical Global Impression Scale Item 2 was employed to evaluate the onset time; meanwhile, Brief Psychiatric Rating Scale (BPRS) was used at baseline and at posttreatment weeks 1, 2, and 4...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29459189/detailed-investigations-into-the-akabori-momotani-reaction-for-the-synthesis-of-amphetamine-type-stimulants-part-2
#12
David Doughty, Emma Kent, Ben Painter, Paul E Pigou, Martin R Johnston
The Akabori-Momotani reaction can be used to synthesise pseudoephedrine in 50% yield from N-methylalanine and benzaldehyde. This paper investigates electronic effects of substituted benzaldehydes on the reaction to synthesise amphetamine type stimulants and identifies several new Akabori-Momotani by-products, 1-[(4-methoxybenzyl)(methyl)amino]ethanol (11c), 2-(4-methoxyphenyl)-3,4-dimethyl-1,3-oxazolidine (12c), 1,2,3,4-tetramethyl-5,6-di-(4-methoxyphenyl)piperazine (13c) and 1,2,4,5-tetramethyl-3,6-di-(4-methoxyphenyl)piperazine (14c)...
February 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29458910/maternal-characteristics-and-pregnancy-outcomes-among-illicit-drug-using-women-in-an-urban-setting
#13
Pitchaya Homsup, Chadakarn Phaloprakarn, Siriwan Tangjitgamol, Sumonmal Manusirivithaya
OBJECTIVE: To identify characteristics and pregnancy outcomes among pregnant illicit drug users living in an urban area, and to describe trends in drug use over an 8-year period. MATERIALS AND METHODS: Data on pregnant women living in the Bangkok Metropolitan Region who delivered at our institution during 2008-2015 were studied. Women with drug use (n = 197) and women without drug use (n = 787) were compared in terms of maternal characteristics and pregnancy outcomes...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29453444/positive-regulation-of-raphe-serotonin-neurons-by-serotonin-2b-receptors
#14
Arnauld Belmer, Emily Quentin, Silvina L Diaz, Bruno P Guiard, Sebastian P Fernandez, Stéphane Doly, Sophie M Banas, Pothitos M Pitychoutis, Imane Moutkine, Aude Muzerelle, Anna Tchenio, Anne Roumier, Manuel Mameli, Luc Maroteaux
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT2B receptors directly and positively regulate raphe serotonin neuron activity...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29429705/synthesis-of-novel-sonocatalyst-er3-yalo3-nb2o5-and-its-application-for-sonocatalytic-degradation-of-methamphetamine-hydrochloride
#15
Chunsheng Wei, Kuiyu Yi, Guangsheng Sun, Jun Wang
The composited sonocatalyst Er3+:YAlO3/Nb2O5 was prepared by ultrasonic dispersion and high temperature calcinations method. The microstructure of Er3+:YAlO3 was prepared via sol-gel method and Nb2O5 was prepared by hydrothermal method. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), ultraviolet-visible (UV-vis) spectra and photoluminescence (PL) spectra, respectively. The sonocatalytic decomposition activity of composite sonocatalyst Er3+:YAlO3/Nb2O5 was investigated by using ultrasound as sound source and methamphetamine hydrochloride as the target degradation product...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29406033/determination-and-long-term-stability-of-twenty-nine-cathinones-and-amphetamine-type-stimulants-ats-in-urine-using-gas-chromatography-mass-spectrometry
#16
Khalid A Alsenedi, Calum Morrison
A method was developed for the screening and quantification of seven amphetamine-type stimulants (ATS) and 22 cathinones, including three metabolites, in urine with Gas Chromatography-Mass Spectrometry. This method allowed the detection and quantification of ATS and cathinones group molecules using one procedure. A study of the stability of the drug mixtures for a period of 201 days in human urine samples under three different conditions has been carried. The ATS and cathinones include amphetamine, methamphetamine, MDA, MDEA, MDMA, PMA, PMMA, cathinone, methcathinone, 3'-position-substituted, ring-substituted, methylenedioxy-substituted, N-alkyl-substituted and pyrrolidinyl-substituted...
February 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29406017/examining-the-effectiveness-of-acetylcholinesterase-inhibitors-and-stimulant-based-medications-for-cognitive-dysfunction-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#17
REVIEW
Jack Cotter, Nils Muhlert, Anahita Talwar, Kiri Granger
We sought to examine the effectiveness of acetylcholinesterase inhibitors (AChEIs) and stimulant-based medications for improving cognitive performance in patients with multiple sclerosis (MS). An electronic database search was conducted on 25th March 2017. Eligible studies were double-blind, randomised, placebo-controlled trials that examined the efficacy of compounds that act primarily as AChEIs or stimulants (administered daily for ≥1 week) on cognitive outcome measures in patients with MS. Where suitable data was reported, we generated effect sizes and corresponding 95% confidence intervals and performed meta-analyses using random-effects models to investigate the effectiveness of these drug types across cognitive domains...
March 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29364035/regulator-of-g-protein-signaling-12-modulates-the-dopamine-transporter-in-ventral-striatum-and-locomotor-responses-to-psychostimulants
#18
Joshua D Gross, Shane W Kaski, Adam B Schroer, Kimberley A Wix, David P Siderovski, Vincent Setola
Regulators of G protein signaling are proteins that accelerate the termination of effector stimulation after G protein-coupled receptor activation. Many regulators of G protein signaling proteins are highly expressed in the brain and therefore considered potential drug discovery targets for central nervous system pathologies; for example, here we show that RGS12 is highly expressed in microdissected mouse ventral striatum. Given a role for the ventral striatum in psychostimulant-induced locomotor activity, we tested whether Rgs12 genetic ablation affected behavioral responses to amphetamine and cocaine...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29298737/a-feasible-model-for-early-intervention-for-high-risk-substance-use-in-the-emergency-department-setting
#19
Rebecca Howard, Stephanie Fry, Andrew Chan, Brigid Ryan, Yvonne Bonomo
Objective In response to escalating alcohol and other drug (AOD)-related emergency department (ED) presentations, a tertiary Melbourne hospital embedded experienced AOD clinical nurse consultants in the ED on weekends to trial a model for screening, assessment and brief intervention (BI). The aim of the present study was to evaluate the relative contributions of AOD to ED presentations and to pilot a BI model. Methods Using a customised AOD screening tool and a framework for proactive case finding, screened participants were offered a comprehensive AOD assessment and BI in the ED...
January 4, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29175556/rapid-and-simple-procedure-for-the-determination-of-cathinones-amphetamine-like-stimulants-and-other-new-psychoactive-substances-in-blood-and-urine-by-gc-ms
#20
Gilbert Mercieca, Sara Odoardi, Marisa Cassar, Sabina Strano Rossi
In the last few years an increasing number of new psychoactive substances (NPS), with different chemical structures (of which 37% are stimulants), have been released into the illicit drug market. Their detection and identification in biological samples is hence of great concern. The aim of this work was to develop a high-throughput and rapid method for the determination of different classes of stimulants (amphetamine-type stimulants, cathinones, phenethylamines and ketamine analogues) from blood and urine samples using GC-MS...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
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