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Brain cortical thickness

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https://www.readbyqxmd.com/read/29331877/cerebral-changes-and-disrupted-gray-matter-cortical-networks-in-asymptomatic-older-adults-at-risk-for-alzheimer-s-disease
#1
Jose L Cantero, Mercedes Atienza, Pascual Sanchez-Juan, Eloy Rodriguez-Rodriguez, Jose Luis Vazquez-Higuera, Ana Pozueta, Andrea Gonzalez-Suarez, Eduard Vilaplana, Jordi Pegueroles, Victor Montal, Rafael Blesa, Daniel Alcolea, Alberto Lleo, Juan Fortea
The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-β (Aβ1-42+) (N = 19), and positive phosphorylated tau (N = 18)...
December 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29327392/differences-in-white-matter-structure-and-cortical-thickness-between-patients-with-traumatic-and-idiopathic-chronic-neck-pain-associations-with-cognition-and-pain-modulation
#2
I Coppieters, R De Pauw, K Caeyenberghs, D Lenoir, K DeBlaere, E Genbrugge, M Meeus, B Cagnie
Brain alterations are hypothesized to be present in patients with chronic whiplash-associated disorders (CWAD). The aim of this case-control study was to examine alterations in cortical thickness and white matter (WM) structure, and the presence of brain microhemorrhages in a patient group encountering chronic neck pain of traumatic origin (i.e., CWAD) when compared with a patient group characterized by nontraumatic chronic neck pain [i.e., chronic idiopathic neck pain (CINP)], and healthy controls. Furthermore, we aimed to investigate associations between brain structure on one hand and cognitive performance and central sensitization (CS) on the other hand...
January 11, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29322596/subclinical-depressive-symptoms-during-late-midlife-and-structural-brain-alterations-a-longitudinal-study-of-danish-men-born-in-1953
#3
Merete Osler, Lauge Sørensen, Maarten Rozing, Oriol Puig Calvo, Mads Nielsen, Egill Rostrup
We explored whether depressive symptoms measured three times during midlife were associated with structural brain alterations quantified using magnetic resonance imaging measurements of volume, cortical thickness, and intensity texture. In 192 men born in 1953 with depressive symptoms measured at age 51, 56, and 59 years, magnetic resonance imaging was performed at age 59. All data processing was performed using the Freesurfer software package except for the texture-scores that were computed using in-house software...
January 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29321232/hypermyelination-of-the-left-auditory-cortex-in-developmental-dyslexia
#4
Michael A Skeide, Pierre-Louis Bazin, Robert Trampel, Andreas Schäfer, Claudia Männel, Katharina von Kriegstein, Angela D Friederici
OBJECTIVE: Cortical malformations are documented postmortem in speech processing areas of the dyslexic human brain. The goal of this pilot study was to find out if such anatomic anomalies can be detected noninvasively and in vivo. METHODS: We developed a reconstruction of left perisylvian cortex profiles at a resolution of 400 μm using T1 data acquired with ultra-high-field MRI at 7T. Cortical thickness, myelinated cortical thickness, and layer-wise myelination were then compared in 6 men with developmental dyslexia and 6 healthy controls matched for age, sex, handedness, education level, and nonverbal IQ...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29316528/altered-structural-network-organization-in-cognitively-normal-individuals-with-amyloid-pathology
#5
Olga Voevodskaya, Joana B Pereira, Giovanni Volpe, Olof Lindberg, Erik Stomrud, Danielle van Westen, Eric Westman, Oskar Hansson
Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels)...
December 7, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29313947/personality-traits-are-associated-with-cortical-development-across-adolescence-a-longitudinal-structural-mri-study
#6
Lia Ferschmann, Anders M Fjell, Margarete E Vollrath, Håkon Grydeland, Kristine B Walhovd, Christian K Tamnes
How personality traits relate to structural brain changes in development is an important but understudied question. In this study, cortical thickness (CT) and surface area (SA), estimated using magnetic resonance imaging (MRI), were investigated in 99 participants aged 8-19 years. Follow-up MRI data were collected after on average 2.6 years for 74 individuals. The Big Five personality traits were related to longitudinal regional CT or SA development, but limited cross-sectional relations were observed. Conscientiousness, emotional stability, and imagination were associated with more age-expected cortical thinning over time...
January 4, 2018: Child Development
https://www.readbyqxmd.com/read/29306697/current-sleep-disturbance-in-older-people-with-a-lifetime-history-of-depression-is-associated-with-increased-connectivity-in-the-default-mode-network
#7
Andrew C McKinnon, Ian B Hickie, Jan Scott, Shantel L Duffy, Louisa Norrie, Zoe Terpening, Ron R Grunstein, Jim Lagopoulos, Jennifer Batchelor, Simon J G Lewis, James M Shine, Sharon L Naismith
BACKGROUND: The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. METHODS: A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted)...
December 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29306053/cd38-is-required-for-dendritic-organisation-in-visual-cortex-and-hippocampus
#8
Thom P Nelissen, Rosemary A Bamford, Shiro Tochitani, Kamuran Akkus, Aurimas Kudzinskas, Kenichiro Yokoi, Hiroshi Okamoto, Yasuhiko Yamamoto, J Peter H Burbach, Hideo Matsuzaki, Asami Oguro-Ando
Morphological screening of mouse brains with known behavioural deficits can give great insight into the relationship between brain regions and their behaviour. Oxytocin- and CD38-deficient mice have previously been shown to have behavioural phenotypes, such as restrictions in social memory, social interactions, and maternal behaviour. CD38 is reported as an autism spectrum disorder (ASD) candidate gene and these behavioural phenotypes may be linked to ASD. To address whether these behavioural phenotypes relate to brain pathology and neuronal morphology, here we investigate the morphological changes in the CD38-deficient mice brains, with focus on the pathology and neuronal morphology of the cortex and hippocampus, using Nissl staining, immunohistochemistry, and Golgi staining...
January 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29301597/surface-based-morphometry-of-human-brain-intra-individual-comparison-between-3t-and-7t-high-resolution-structural-mr-imaging
#9
Zhiye Chen, Meng-Qi Liu, Lin Ma
ObjectiveHigh resolution structural MR imaging can reveal structural characteristics of cerebral cortex and provide an insight into normal brain development and neuropsychological diseases. The aim of this study was to compare cortical structural characteristics of normal human brain between 3T and 7T MRI systems using surface-based morphometry based on high resolution structural MR imaging. Methods Twelve healthy volunteers were scanned by both 3T with 3D T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence and 7T with 3D T1-weighted magnetization-prepared rapid gradient echo (3D T1-MPRAGE) sequence...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29299390/cortical-morphology-in-patients-with-transient-global-amnesia
#10
Hyung Chan Kim, Byung In Lee, Sung Eun Kim, Kang Min Park
Objective: This study evaluated alterations in cortical morphology in patients with transient global amnesia (TGA). Materials and Methods: Diagnoses of TGA occurred at our hospital. Evaluation involved a structured interview to obtain clinical information and a brain magnetic resonance imaging scan. We analyzed whole-brain T1-weighted MRI data using FreeSurfer 5.1. Measures of cortical morphology, such as thickness, surface area, volume, and curvature were compared between patients with TGA and healthy controls...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29288952/effects-of-the-brain-derived-neurotropic-factor-variant-val66met-on-cortical-structure-in-late-childhood-and-early-adolescence
#11
Celia Maria de Araujo, Andre Zugman, Walter Swardfager, Sintia Iole Nogueira Belangero, Vanessa Kiyomi Ota, Leticia Maria Spindola, Hakon Hakonarson, Renata Pellegrino, Ary Gadelha, Giovanni Abrahão Salum, Pedro Mario Pan, Luciana Monteiro de Moura, Marco Del Aquilla, Felipe Almeida Picon, Edson Amaro, João Ricardo Sato, Elisa Brietzke, Rodrigo Grassi-Oliveira, Luis Augusto P Rohde, Euripedes Constantino Miguel, Rodrigo A Bressan, Andrea Parolin Jackowski
BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. METHODOLOGY: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder...
December 20, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29287966/structural-brain-differences-between-monolingual-and-multilingual-patients-with-mild-cognitive-impairment-and-alzheimer-disease-evidence-for-cognitive-reserve
#12
Hilary D Duncan, Jim Nikelski, Randi Pilon, Jason Steffener, Howard Chertkow, Natalie A Phillips
Two independent lines of research provide evidence that speaking more than one language may 1) contribute to increased grey matter in healthy younger and older adults and 2) delay cognitive symptoms in mild cognitive impairment (MCI) or Alzheimer disease (AD). We examined cortical thickness and tissue density in monolingual and multilingual MCI and AD patients matched (within Diagnosis Groups) on demographic and cognitive variables. In medial temporal disease-related (DR) areas, we found higher tissue density in multilingual MCIs versus monolingual MCIs, but similar or lower tissue density in multilingual AD versus monolingual AD, a pattern consistent with cognitive reserve in AD...
December 26, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29285552/focal-cortical-thinning-in-patients-with-stable-relapsing-remitting-multiple-sclerosis-cross-sectional-based-novel-estimation-of-gray-matter-kinetics
#13
Lior Orbach, Shay Menascu, Chen Hoffmann, Shmuel Miron, Anat Achiron
PURPOSE: The aim of our study is to identify radiological patterns of cortical gray matter atrophy (CGMA) that correlate with disease duration in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: RRMS patients were randomly selected from the Sheba Multiple Sclerosis (MS) center computerized data registry based on stratification of disease duration up to 10 years. Patients were scanned by 3.0 T (Signa, GE) MRI, using a T1 weighted 3D high resolution, FSPGR, MS protocol...
February 2018: Neuroradiology
https://www.readbyqxmd.com/read/29285207/weight-loss-in-the-healthy-elderly-might-be-a-non-cognitive-sign-of-preclinical-alzheimer-s-disease
#14
Amanda Jimenez, Jordi Pegueroles, María Carmona-Iragui, Eduard Vilaplana, Victor Montal, Daniel Alcolea, Laura Videla, Ignacio Illán-Gala, Adriana Pané, Anna Casajoana, Olivia Belbin, Jordi Clarimón, Violeta Moizé, Josep Vidal, Alberto Lleó, Juan Fortea, Rafael Blesa
Weight loss has been proposed as a sign of pre-clinical Alzheimer Disease (AD). To test this hypothesis, we have evaluated the association between longitudinal changes in weight trajectories, cognitive performance, AD biomarker profiles and brain structure in 363 healthy controls from the Alzheimer´s Disease Neuroimaging Initiative (mean follow-up 50.5±30.5 months). Subjects were classified according to body weight trajectory into a weight loss group (WLG; relative weight loss ≥ 5%) and a non-weight loss group (non-WLG; relative weight loss < 5%)...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282709/neurodevelopmental-origins-of-abnormal-cortical-morphology-in-dissociative-identity-disorder
#15
A A T S Reinders, S Chalavi, Y R Schlumpf, E M Vissia, E R S Nijenhuis, L Jäncke, D J Veltman, C Ecker
OBJECTIVE: To examine the two constitutes of cortical volume (CV), that is, cortical thickness (CT) and surface area (SA), in individuals with dissociative identity disorder (DID) with the view of gaining important novel insights into the underlying neurobiological mechanisms mediating DID. METHODS: This study included 32 female patients with DID and 43 matched healthy controls. Between-group differences in CV, thickness, and SA, the degree of spatial overlap between differences in CT and SA, and their relative contribution to differences in regional CV were assessed using a novel spatially unbiased vertex-wise approach...
December 27, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29278774/data-driven-assessment-of-structural-image-quality
#16
Adon F G Rosen, David R Roalf, Kosha Ruparel, Jason Blake, Kevin Seelaus, Lakshmi P Villa, Rastko Ciric, Philip A Cook, Christos Davatzikos, Mark A Elliott, Angel Garcia de La Garza, Efstathios D Gennatas, Megan Quarmley, J Eric Schmitt, Russell T Shinohara, M Dylan Tisdall, R Cameron Craddock, Raquel E Gur, Ruben C Gur, Theodore D Satterthwaite
Data quality is increasingly recognized as one of the most important confounding factors in brain imaging research. It is particularly important for studies of brain development, where age is systematically related to in-scanner motion and data quality. Prior work has demonstrated that in-scanner head motion biases estimates of structural neuroimaging measures. However, objective measures of data quality are not available for most structural brain images. Here we sought to identify quantitative measures of data quality for T1-weighted volumes, describe how such measures of quality relate to cortical thickness, and delineate how this in turn may bias inference regarding associations with age in youth...
December 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/29275185/characteristics-of-gray-matter-morphological-change-in-parkinson-s-disease-patients-with-semantic-abstract-reasoning-deficits
#17
Li Wang, Kun Nie, Xin Zhao, Shujun Feng, Sifen Xie, Xuetao He, Guixian Ma, Limin Wang, Zhiheng Huang, Biao Huang, Yuhu Zhang, Lijuan Wang
BACKGROUND: Semantic abstract reasoning(SAR) is an important executive domain that is involved in semantic information processing and enables one to make sense of the attributes of objects, facts and concepts in the world. We sought to investigate whether Parkinson's disease subjects(PDs) have difficulty in SAR and to examine the associated pattern of gray matter morphological changes. METHODS: Eighty-six PDs and 30 healthy controls were enrolled. PDs were grouped into PD subjects with Similarities preservation(PDSP, n = 62) and PD subjects with Similarities impairment(PDSI, n = 24)according to their performance on the Similarities subtest of the Wechsler Adult Intelligence Scale...
December 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29274746/structural-covariance-networks-are-coupled-to-expression-of-genes-enriched-in-supragranular-layers-of-the-human-cortex
#18
Rafael Romero-Garcia, Kirstie J Whitaker, František Váša, Jakob Seidlitz, Maxwell Shinn, Peter Fonagy, Raymond J Dolan, Peter B Jones, Ian M Goodyer
Complex network topology is characteristic of many biological systems, including anatomical and functional brain networks (connectomes). Here, we first constructed a structural covariance network from MRI measures of cortical thickness on 296 healthy volunteers, aged 14-24 years. Next, we designed a new algorithm for matching sample locations from the Allen Brain Atlas to the nodes of the SCN. Subsequently we used this to define, transcriptomic brain networks by estimating gene co-expression between pairs of cortical regions...
December 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29259302/modelling-neuroanatomical-variation-during-childhood-and-adolescence-with-neighbourhood-preserving-embedding
#19
Gareth Ball, Chris Adamson, Richard Beare, Marc L Seal
Brain development is a dynamic process with tissue-specific alterations that reflect complex and ongoing biological processes taking place during childhood and adolescence. Accurate identification and modelling of these anatomical processes in vivo with MRI may provide clinically useful imaging markers of individual variability in development. In this study, we use manifold learning to build a model of age- and sex-related anatomical variation using multiple magnetic resonance imaging metrics. Using publicly available data from a large paediatric cohort (n = 768), we apply a multi-metric machine learning approach combining measures of tissue volume, cortical area and cortical thickness into a low-dimensional data representation...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251844/convergent-neurobiological-predictors-of-emergent-psychopathology-during-adolescence
#20
REVIEW
Scott A Jones, Angelica M Morales, Jessye B Lavine, Bonnie J Nagel
The adolescent brain undergoes significant structural and functional development. Through the use of magnetic resonance imaging in adolescents, it has been demonstrated that the prefrontal cortex, pertinent for executive control, demonstrates protracted development compared to limbic structures, active during emotion and reward processing. This asynchronous development creates a sensitive window during adolescence, in which many psychopathological disorders (i.e., mental health and substance use) emerge. This review outlines longitudinal studies that use magnetic resonance imaging to identify neurobiological predictors of emergent psychopathology (depression, anxiety, and substance use), during adolescence...
December 1, 2017: Birth Defects Research
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