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Brain cortical thickness

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https://www.readbyqxmd.com/read/28633986/gray-matter-abnormalities-in-non-comorbid-medication-naive-patients-with-major-depressive-disorder-or-social-anxiety-disorder
#1
Youjin Zhao, Lizhou Chen, Wenjing Zhang, Yuan Xiao, Chandan Shah, Hongru Zhu, Minlan Yuan, Huaiqiang Sun, Qiang Yue, Zhiyun Jia, Wei Zhang, Weihong Kuang, Qiyong Gong, Su Lui
BACKGROUND: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. METHODS: High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs)...
June 15, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28629404/white-matter-lesions-characterise-brain-involvement-in-moderate-to-severe-chronic-obstructive-pulmonary-disease-but-cerebral-atrophy-does-not
#2
Catherine A Spilling, Paul W Jones, James W Dodd, Thomas R Barrick
BACKGROUND: Brain pathology is relatively unexplored in chronic obstructive pulmonary disease (COPD). This study is a comprehensive investigation of grey matter (GM) and white matter (WM) changes and how these relate to disease severity and cognitive function. METHODS: T1-weighted and fluid-attenuated inversion recovery images were acquired for 31 stable COPD patients (FEV1 52.1% pred., PaO2 10.1 kPa) and 24 age, gender-matched controls. T1-weighted images were segmented into GM, WM and cerebrospinal fluid (CSF) tissue classes using a semi-automated procedure optimised for use with this cohort...
June 19, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28627714/migraine-subclassification-via-a-data-driven-automated-approach-using-multimodality-factor-mixture-modeling-of-brain-structure-measurements
#3
Todd J Schwedt, Bing Si, Jing Li, Teresa Wu, Catherine D Chong
BACKGROUND: The current subclassification of migraine is according to headache frequency and aura status. The variability in migraine symptoms, disease course, and response to treatment suggest the presence of additional heterogeneity or subclasses within migraine. OBJECTIVE: The study objective was to subclassify migraine via a data-driven approach, identifying latent factors by jointly exploiting multiple sets of brain structural features obtained via magnetic resonance imaging (MRI)...
June 19, 2017: Headache
https://www.readbyqxmd.com/read/28625674/regional-cerebral-cortical-thickness-correlates-with-autonomic-outflow
#4
REVIEW
Katelyn N Wood, Mark B Badrov, Mark R Speechley, J Kevin Shoemaker
Dysregulation of autonomic control often develops with advancing age, favoring a chronic state of heightened sympathetic outflow with parasympathetic withdrawal. However, the mechanisms of this age-related autonomic impairment are not known. This study tested the hypothesis that inter-individual differences in autonomic outflow across the adult age-span are related to cerebral cortex thickness. A total of 55 healthy, active individuals participated in this study (21-73years; 18 female). Physical fitness was treated as a possible covariate (VO2peak: 26-81mL/kg/min)...
June 7, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28625224/auditory-verbal-hallucinations-are-related-to-cortical-thinning-in-the-left-middle-temporal-gyrus-of-patients-with-schizophrenia
#5
Y Cui, B Liu, M Song, D M Lipnicki, J Li, S Xie, Y Chen, P Li, L Lu, L Lv, H Wang, H Yan, J Yan, H Zhang, D Zhang, T Jiang
BACKGROUND: Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms of schizophrenia, but the neuroanatomical abnormalities underlying AVHs are not well understood. The present study aims to investigate whether AVHs are associated with cortical thinning. METHODS: Participants were schizophrenia patients from four centers across China, 115 with AVHs and 93 without AVHs, as well as 261 healthy controls. All received 3 T T1-weighted brain scans, and whole brain vertex-wise cortical thickness was compared across groups...
June 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28622141/analysis-of-structural-brain-mri-and-multi-parameter-classification-for-alzheimer-s-disease
#6
Yingteng Zhang, Shenquan Liu
Incorporating with machine learning technology, neuroimaging markers which extracted from structural Magnetic Resonance Images (sMRI), can help distinguish Alzheimer's Disease (AD) patients from Healthy Controls (HC). In the present study, we aim to investigate differences in atrophic regions between HC and AD and apply machine learning methods to classify these two groups. T1-weighted sMRI scans of 158 patients with AD and 145 age-matched HC were acquired from the ADNI database. Five kinds of parameters (i...
June 15, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28620297/racial-differences-in-insular-connectivity-and-thickness-and-related-cognitive-impairment-in-hypertension
#7
Ganesh B Chand, Junjie Wu, Deqiang Qiu, Ihab Hajjar
Hypertensive African-Americans have a greater risk of cognitive impairment than hypertensive Caucasian-Americans. The neural basis of this increased risk is yet unknown. Neuroimaging investigations suggest that the normal neural activity comprises complex interactions between brain networks. Recent studies consistently demonstrate that the insula, part of the salience network, provides modulation effects (information flow) over the default-mode and central-executive networks in cognitively normal subjects, and argue that the modulation effect is declined in cognitive impairment...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28616383/multiparametric-mri-to-distinguish-early-onset-alzheimer-s-disease-and-behavioural-variant-of-frontotemporal-dementia
#8
Elisa Canu, Federica Agosta, Gorana Mandic-Stojmenovic, Tanja Stojković, Elka Stefanova, Alberto Inuggi, Francesca Imperiale, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
This prospective study explored whether an approach combining structural [cortical thickness and white matter (WM) microstructure] and resting state functional MRI can aid differentiation between 62 early onset Alzheimer's disease (EOAD) and 27 behavioural variant of frontotemporal dementia (bvFTD) patients. Random forest and receiver operator characteristic curve analyses assessed the ability of MRI in classifying the two clinical syndromes. All patients showed a distributed pattern of brain alterations relative to controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28608653/complementary-cortical-gray-and-white-matter-developmental-patterns-in-healthy-preterm-neonates
#9
Vidya Rajagopalan, Julia A Scott, Mengyuan Liu, Kenneth Poskitt, Vann Chau, Steven Miller, Colin Studholme
Preterm birth is associated with brain injury and altered cognitive development. However, the consequences of extrauterine development are not clearly distinguished from perinatal brain injury. Therefore, we characterized cortical growth patterns from 30 to 46 postmenstrual weeks (PMW) in 27 preterm neonates (25-32 PMW at birth) without detectable brain injury on magnetic resonance imaging. We introduce surface-based morphometric descriptors that quantify radial (thickness) and tangential (area) change rates...
June 13, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28603479/mri-analysis-of-white-matter-myelin-water-content-in-multiple-sclerosis-a-novel-approach-applied-to-finding-correlates-of-cortical-thinning
#10
Michael Dayan, Sandra M Hurtado Rúa, Elizabeth Monohan, Kyoko Fujimoto, Sneha Pandya, Eve M LoCastro, Tim Vartanian, Thanh D Nguyen, Ashish Raj, Susan A Gauthier
A novel lesion-mask free method based on a gamma mixture model was applied to myelin water fraction (MWF) maps to estimate the association between cortical thickness and myelin content, and how it differs between relapsing-remitting (RRMS) and secondary-progressive multiple sclerosis (SPMS) groups (135 and 23 patients, respectively). It was compared to an approach based on lesion masks. The gamma mixture distribution of whole brain, white matter (WM) MWF was characterized with three variables: the mode (most frequent value) m1 of the gamma component shown to relate to lesion, the mode m2 of the component shown to be associated with normal appearing (NA) WM, and the mixing ratio (λ) between the two distributions...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28600458/structural-mri-markers-of-brain-aging-early-after-ischemic-stroke
#11
Emilio Werden, Toby Cumming, Qi Li, Laura Bird, Michele Veldsman, Heath R Pardoe, Graeme Jackson, Geoffrey A Donnan, Amy Brodtmann
OBJECTIVE: To examine associations between ischemic stroke, vascular risk factors, and MRI markers of brain aging. METHODS: Eighty-one patients (mean age 67.5 ± 13.1 years, 31 left-sided, 61 men) with confirmed first-ever (n = 66) or recurrent (n = 15) ischemic stroke underwent 3T MRI scanning within 6 weeks of symptom onset (mean 26 ± 9 days). Age-matched controls (n = 40) completed identical testing. Multivariate regression analyses examined associations between group membership and MRI markers of brain aging (cortical thickness, total brain volume, white matter hyperintensity [WMH] volume, hippocampal volume), normalized against intracranial volume, and the effects of vascular risk factors on these relationships...
June 9, 2017: Neurology
https://www.readbyqxmd.com/read/28598850/recovery-from-proactive-semantic-interference-and-mri-volume-a%C3%A2-replication-and-extension-study
#12
David A Loewenstein, Rosie E Curiel, Steven DeKosky, Monica Rosselli, Russell Bauer, Maria Grieg-Custo, Ailyn Penate, Chunfei Li, Gabriel Lizagarra, Todd Golde, Malek Adjouadi, Ranjan Duara
BACKGROUND: The rise in incidence of Alzheimer's disease (AD) has led to efforts to advance early detection of the disease during its preclinical stages. To achieve this, the field needs to develop more sensitive cognitive tests that relate to biological markers of disease pathology. Failure to recover from proactive interference (frPSI) is one such cognitive marker that is associated with volumetric reductions in the hippocampus, precuneus, and other AD-prone regions, and to amyloid load in the brain...
June 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28594150/cortical-thickness-is-not-associated-with-current-depression-in-a-clinical-treatment-study
#13
Greg Perlman, Elizabeth Bartlett, Christine DeLorenzo, Myrna Weissman, Patrick McGrath, Todd Ogden, Tony Jin, Phillip Adams, Madhukar Trivedi, Benji Kurian, Maria Oquendo, Melvin McInnis, Sarah Weyandt, Maurizio Fava, Crystal Cooper, Ashley Malchow, Ramin Parsey
BACKGROUND: Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent. This could reflect analytic heterogeneity, such as use of region-wise cortical thickness based on the Freesurfer Desikan-Killiany (DK) atlas or surface-based morphometry (SBM). The Freesurfer Destrieux (DS) atlas (more, smaller regions) has not been utilized in depression studies. This could also reflect differential gender and age effects. METHODS: Cortical thickness was collected from 170 currently depressed adults and 52 never-depressed adults...
June 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28591795/socioeconomic-status-and-reading-disability-neuroanatomy-and-plasticity-in-response-to-intervention
#14
Rachel R Romeo, Joanna A Christodoulou, Kelly K Halverson, Jack Murtagh, Abigail B Cyr, Carly Schimmel, Patricia Chang, Pamela E Hook, John D E Gabrieli
Although reading disability (RD) and socioeconomic status (SES) are independently associated with variation in reading ability and brain structure/function, the joint influence of SES and RD on neuroanatomy and/or response to intervention is unknown. In total, 65 children with RD (ages 6-9) with diverse SES were assigned to an intensive, 6-week summer reading intervention (n = 40) or to a waiting-list control group (n = 25). Before and after, all children completed standardized reading assessments and magnetic resonance imaging to measure cortical thickness...
June 7, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28588470/examining-brain-morphometry-associated-with-self-esteem-in-young-adults-using-multilevel-roi-features-based-classification-method
#15
Bo Peng, Jieru Lu, Aditya Saxena, Zhiyong Zhou, Tao Zhang, Suhong Wang, Yakang Dai
Purpose: This study is to exam self-esteem related brain morphometry on brain magnetic resonance (MR) images using multilevel-features-based classification method. Method: The multilevel region of interest (ROI) features consist of two types of features: (i) ROI features, which include gray matter volume, white matter volume, cerebrospinal fluid volume, cortical thickness, and cortical surface area, and (ii) similarity features, which are based on similarity calculation of cortical thickness between ROIs. For each feature type, a hybrid feature selection method, comprising of filter-based and wrapper-based algorithms, is used to select the most discriminating features...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28588345/neuroanatomic-variations-in-graves-dysthyroid-ophthalmopathy-as-studied-with-mri
#16
Rona Z Silkiss, Alex R Wade
PURPOSE: To evaluate whether patients with Graves' dysthyroid ophthalmopathy (GDO) have changes in brain anatomy that can be assessed by neuroimaging as compared to age-matched controls. METHODS: We examined 10 female, euthyroid patients with GDO and 14 age and gender matched controls using high-resolution structural MRI scanning. An automatic cortical segmentation algorithm was used to estimate the thickness of each subject's gray matter across the brain. The resulting cortical thickness measurements were transferred to a standard reference space via a template-based warping procedure...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28582627/gyrification-inspired-highly-convoluted-graphene-oxide-patterns-for-ultralarge-deforming-actuators
#17
Yinlong Tan, Zengyong Chu, Zhenhua Jiang, Tianjiao Hu, Gongyi Li, Jia Song
Gyrification in the human brain is driven by the compressive stress induced by the tangential expansion of the cortical layer, while similar topographies can also be induced by the tangential shrinkage of the spherical substrate. Herein we introduce a simple three-dimensional (3D) shrinking method to generate the cortex-like patterns using two-dimensional (2D) graphene oxide (GO) as the building blocks. By rotation-dip-coating a GO film on an air-charged latex balloon and then releasing the air slowly, a highly folded hydrophobic GO surface can be induced...
June 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28579694/bilingualism-influences-structural-indices-of-interhemispheric-organization
#18
Adam Felton, David Vazquez, Aurora I Ramos-Nunez, Maya R Greene, Alessandra McDowell, Arturo E Hernandez, Christine Chiarello
Bilingualism represents an interesting model of possible experience-dependent alterations in brain structure. The current study examines whether interhemispheric adaptations in brain structure are associated with bilingualism. Corpus callosum volume and cortical thickness asymmetry across 13 regions of interest (selected to include critical language and bilingual cognitive control areas) were measured in a sample of Spanish-English bilinguals and age- and gender-matched monolingual individuals (N = 39 per group)...
May 2017: Journal of Neurolinguistics
https://www.readbyqxmd.com/read/28579519/contributions-of-polygenic-risk-for-obesity-to-ptsd-related-metabolic-syndrome-and-cortical-thickness
#19
Erika J Wolf, Danielle R Miller, Mark W Logue, Jennifer Sumner, Tawni B Stoop, Elizabeth C Leritz, Jasmeet P Hayes, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Research suggests that posttraumatic stress disorder (PTSD) is associated with metabolic syndrome (MetS) and that PTSD-associated MetS is related to decreased cortical thickness. However, the role of genetic factors in these associations is unclear. This study evaluated contributions of polygenic obesity risk and PTSD to MetS and of MetS and polygenic obesity risk to cortical thickness. METHODS: 196 white, non-Hispanic veterans of the wars in Iraq and Afghanistan underwent clinical diagnostic interviews, physiological assessments, and genome-wide genotyping; 168 also completed magnetic resonance imaging scans...
June 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28572766/conversion-discriminative-analysis-on-mild-cognitive-impairment-using-multiple-cortical-features-from-mr-images
#20
Shengwen Guo, Chunren Lai, Congling Wu, Guiyin Cen
Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups...
2017: Frontiers in Aging Neuroscience
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