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https://www.readbyqxmd.com/read/29235616/-social-cognition-in-parkinson-s-disease-dementia-and-behavioral-variant-of-frontotemporal-dementia
#1
M E Tabernero, F Musich, F C Cossini, D G Politis
AIM: To study the presence of alterations in social cognition in Parkinson's disease dementia (PDD) and behavioral variant frontotemporal dementia (bvFTD), to compare the levels of involvement, and to analyze their relevance as a tool to distinguish between both demential profile. SUBJECTS AND METHODS: For this purpose, 34 patients diagnosed with PDD, 21 men and 13 women, with an average age of 70 years and 8 years of education, and 26 patients diagnosed with bvFTD, 9 men and 17 women, with an average age of 68 years and 6 years of education, were assessed...
December 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29234305/functional-components-of-cognitive-impairment-in-multiple-sclerosis-a-cross-sectional-investigation
#2
Jordi A Matias-Guiu, Ana Cortés-Martínez, María Valles-Salgado, Celia Oreja-Guevara, Vanesa Pytel, Paloma Montero, Teresa Moreno-Ramos, Jorge Matias-Guiu
Background: Cognitive impairment is frequent and disabling in multiple sclerosis (MS). Changes in information processing speed constitute the most important cognitive deficit in MS. However, given the clinical and topographical variability of the disease, cognitive impairment may vary greatly and appear in other forms in addition to slower information processing speed. Our aim was to determine the frequency of cognitive impairment, the principal cognitive domains, and components involved in MS and to identify factors associated with presence of cognitive impairment in these patients in a large series of patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29233210/optical-coherence-tomography-indices-of-structural-retinal-pathology-in-schizophrenia
#3
Steven M Silverstein, Danielle Paterno, Lindsay Cherneski, Stuart Green
BACKGROUND: Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia occurs independently of comorbid medical conditions that affect the retina; (2) thinning is independent of antipsychotic medication dose; (3) optic nerve parameters are abnormal in schizophrenia; and (4) OCT indices are related to visual and cognitive impairments common in schizophrenia...
December 13, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29229614/does-pride-really-come-before-a-fall-longitudinal-analysis-of-older-english-adults
#4
D McMinn, S J Fergusson, M Daly
OBJECTIVE: To test whether high levels of reported pride are associated with subsequent falls. DESIGN: Secondary analysis of the English Longitudinal Study of Ageing (ELSA) dataset. SETTING: Multi-wave longitudinal sample of non-institutionalised older English adults. PARTICIPANTS: ELSA cohort of 6415 participants at wave 5 (baseline, 2010/11), of whom 4964 were available for follow-up at wave 7 (follow-up, 2014/15)...
December 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29226870/alzheimer-s-disease-progression-factors-influencing-cognitive-decline
#5
Camilla Ferrari, Gemma Lombardi, Cristina Polito, Giulia Lucidi, Silvia Bagnoli, Irene Piaceri, Benedetta Nacmias, Valentina Berti, Debora Rizzuto, Laura Fratiglioni, Sandro Sorbi
BACKGROUND: Alzheimer's disease (AD) patients present high variability in the rate of cognitive decline. Despite the wide knowledge on factors influencing dementia risk, little is known on what accounts for AD progression. Previous studies on this topic have mainly analyzed each factor separately without taking into account the interaction between genetic and non-genetic factors. OBJECTIVE: The aim of the present study is to evaluate the role of demographic, clinical, therapeutic, and genetic factors and their interaction on cognitive decline among newly diagnosed AD patients...
December 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29226809/vitamin-d-supplementation-in-chronic-schizophrenia-patients-treated-with-clozapine-a-randomized-double-blind-placebo-controlled-clinical-trial
#6
Amir Krivoy, Roy Onn, Yael Vilner, Eldar Hochman, Shira Weizman, Amir Paz, Shmuel Hess, Roi Sagy, Shiri Kimhi-Nesher, Ehud Kalter, Tal Friedman, Zvi Friedman, Gil Bormant, Sharon Trommer, Avi Valevski, Abraham Weizman
BACKGROUND: While accumulating evidence suggests that vitamin D deficiency may be involved in the risk to develop schizophrenia and its outcome, there are no studies on vitamin D supplementation in this context. We sought to assess the effect of vitamin D supplementation on psychiatric, cognitive and metabolic parameters in chronic clozapine-treated schizophrenia patients. METHODS: This eight-week, randomized, double-blind, placebo-controlled clinical trial, recruited schizophrenia patients who had been maintained on clozapine treatment for at least 18weeks and had low levels of vitamin D (<75nmol/l) and total PANSS scores >70 (to ascertain the presence of residual symptoms)...
December 2, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29223177/well-being-and-distress-of-patients-with-parkinson-s-disease-a-comparative-investigation
#7
Francesca Vescovelli, Daniele Sarti, Chiara Ruini
BACKGROUND: Psychological resources, such as psychological well-being (PWB) and life satisfaction (LS) can aid individuals suffering from chronic illnesses to cope with their illness. The aim of this study was to investigate PWB, LS, quality of life (QoL), and distress in patients with Parkinson's disease (PD) and to compare them with healthy controls. METHODS: One hundred and thirteen individuals were recruited. Fifty of the participants suffered from PD, while 53 individuals reported other non-neurological diseases...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223069/neuropsychological-and-clinical-heterogeneity-of-cognitive-impairment-in-patients-with-multiple-system-atrophy
#8
Lorena Broseghini Barcelos, Flávia Saad, Carla Giacominelli, Roberta Arb Saba, Patrícia Maria de Carvalho Aguiar, Sonia Maria Azevedo Silva, Vanderci Borges, Paulo Henrique Ferreira Bertolucci, Henrique Ballalai Ferraz
OBJECTIVE: We evaluated neuropsychological tests to compare cognitive impairment between two types of multiple system atrophy: predominant parkinsonism (MSA-P) and predominant cerebellar ataxia (MSA-C). PATIENTS AND METHODS: This cross-sectional study included 14 patients diagnosed with MSA: four with MSA-C and ten with MSA-P. Presence of motor symptoms was determined by using the Unified Rating MSA Scale (URMSAS). Non-motor symptoms were evaluated by the Short Form Health Survey (SF-36), Scales for Outcomes in Parkinson's disease Autonomic (SCOPA-AUT), Hospital Anxiety and Depression Scale (HADS), and Beck Depression Inventory (BDI)...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29222987/frequency-and-correlates-of-tardive-dyskinesia-in-indian-patients-with-type-i-bipolar-disorder
#9
Tess Maria Rajan, Balaji Bharadwaj, Ravi Philip Rajkumar, Prashant Shankarrao Adole
BACKGROUND: Patients with Bipolar Disorder (BD) may have higher risk of Tardive Dyskinesia (TD). Theories for TD include inflammatory or oxidative stress and altered iron metabolism. The current frequency and clinical and biochemical correlates of TD in BD needs exploration. OBJECTIVES: To assess: (1) the frequency of TD in BD; (2) clinical correlates of TD in BD; (3) oxidative stress markers, inflammatory markers and hepcidin in TD in BD. MATERIALS & METHODS: In this cross-sectional study, 170 patients with BD were assessed for clinical characteristics using structured assessments...
December 5, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29222348/insulin-degrading-enzyme-contributes-to-the-pathology-in-a-mixed-model-of-type-2-diabetes-and-alzheimer-s-disease
#10
Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yang
Insulin degrading enzyme (IDE) is believed to act as a junction point of type 2 diabetes (T2D) and Alzheimer's disease (AD), however, the underlying mechanism was not completely clear yet. Transgenic APPSwe/PS1 mice were used as the AD model and were treated with streptozocin/streptozotocin (STZ) to develop a mixed mice model presenting both AD and T2D. Morris Water Maze (MWM) and recognition task were performed to trace the cognitive function. The detection of fasting plasma glucose (FPG) and plasma insulin concentration, and Oral Glucose Tolerance Test (OGTT) were used to trace the metabolism evolution...
December 8, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29220865/silver-nano-particles-ameliorate-learning-and-spatial-memory-of-male-wistar-rats-by-prevention-of-amyloid-fibril-induced-neurotoxicity
#11
H Ramshini, A-S Moghaddasi, L-S Aldaghi, N Mollania, A Ebrahim-Habibi
Alzheimer's disease (AD) is a chronic degenerative disease characterized by the presence of amyloid plaques and neurofibrillary tangles (NFTs), which results into memory and learning impairments. In the present study, we showed that the aggregates formed by a protein that has no link with Alzheimer's disease, namely the hen egg white lysozyme (HEWL), were cytotoxic and decreased spatial learning and memory in rats. The effect of Ag-nano particles (Ag-NPs) was investigated on disruption of amyloid aggregation and preservation of cognitive behavior of rats...
December 8, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29219786/periinsular-anterior-quadrantotomy-technical-note
#12
Giulia Cossu, Sebastien Lebon, Margitta Seeck, Etienne Pralong, Mahmoud Messerer, Eliane Roulet-Perez, Roy Thomas Daniel
Refractory frontal lobe epilepsy has been traditionally treated through a frontal lobectomy. A disconnective technique may allow similar seizure outcomes while avoiding the complications associated with large brain resections. The aim of this study was to describe a new technique of selective disconnection of the frontal lobe that can be performed in cases of refractory epilepsy due to epileptogenic foci involving 1 frontal lobe (anterior to the motor cortex), with preservation of motor function. In addition to the description of the technique, an illustrative case is also presented...
December 8, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29216828/factors-necessary-for-independent-walking-in-patients-with-thalamic-hemorrhage
#13
Shigenori Hiraoka, Shinichiro Maeshima, Hideto Okazaki, Hirokazu Hori, Shinichiro Tanaka, Sayaka Okamoto, Reisuke Funahashi, Kei Yagihashi, Ikuko Fuse, Naoki Asano, Shigeru Sonoda
BACKGROUND: Thalamic hemorrhages cause motor paralysis, sensory impairment, and cognitive dysfunctions, all of which may significantly affect walking independence. We examined the factors related to independent walking in patients with thalamic hemorrhage who were admitted to a rehabilitation hospital. METHODS: We evaluated 128 patients with thalamic hemorrhage (75 men and 53 women; age range, 40-93 years) who were admitted to our rehabilitation hospital. The mean duration from symptom onset to rehabilitation hospital admission was 27...
December 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29214872/measuring-reliable-change-in-cognition-using-the-edinburgh-cognitive-and-behavioural-als-screen-ecas
#14
Christopher Crockford, Judith Newton, Katie Lonergan, Caoifa Madden, Iain Mays, Meabhdh O'Sullivan, Emmet Costello, Marta Pinto-Grau, Alice Vajda, Mark Heverin, Niall Pender, Ammar Al-Chalabi, Orla Hardiman, Sharon Abrahams
BACKGROUND: Cognitive impairment affects approximately 50% of people with amyotrophic lateral sclerosis (ALS). Research has indicated that impairment may worsen with disease progression. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was designed to measure neuropsychological functioning in ALS, with its alternate forms (ECAS-A, B, and C) allowing for serial assessment over time. OBJECTIVE: The aim of the present study was to establish reliable change scores for the alternate forms of the ECAS, and to explore practice effects and test-retest reliability of the ECAS's alternate forms...
December 7, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29214209/the-impact-of-fillers-on-lineup-performance
#15
Stacy A Wetmore, Ryan M McAdoo, Scott D Gronlund, Jeffrey S Neuschatz
Filler siphoning theory posits that the presence of fillers (known innocents) in a lineup protects an innocent suspect from being chosen by siphoning choices away from that innocent suspect. This mechanism has been proposed as an explanation for why simultaneous lineups (viewing all lineup members at once) induces better performance than showups (one-person identification procedures). We implemented filler siphoning in a computational model (WITNESS, Clark, Applied Cognitive Psychology 17:629-654, 2003), and explored the impact of the number of fillers (lineup size) and filler quality on simultaneous and sequential lineups (viewing lineups members in sequence), and compared both to showups...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29213530/disease-awareness-may-increase-risk-of-suicide-in-young-onset-dementia-a-case-report
#16
Maria Alice Tourinho Baptista, Raquel Luiza Santos, Nathália Kimura, Isabel Barbeito Lacerda, Marcia Cristina Nascimento Dourado
Studies report that people with young onset Alzheimer's disease (YOAD) have higher levels of disease awareness compared to those with late onset AD. We report a case of a man with YOAD who had preserved awareness of disease, depression and risk of suicide associated with the development of the dementia. Cognitive functioning, disease severity, depressive symptoms and awareness of disease were assessed using validated measures. The person with YOAD showed a moderate level of disease severity and high degree of dependence for activities of daily living...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213518/cognitive-impairment-of-patients-with-chronic-renal-disease-on-hemodialysis-and-its-relationship-with-sociodemographic-and-clinical-characteristics
#17
Gabriela Dutra Gesualdo, Juliana Gomes Duarte, Marisa Silvana Zazzetta, Luciana Kusumota, Karina Gramani Say, Sofia Cristina Iost Pavarini, Fabiana de Souza Orlandi
Cognitive impairment and dementia commonly occur in individuals with chronic kidney disease, especially in advanced stages, but are still poorly diagnosed. OBJECTIVE: To evaluate the cognitive ability of patients with chronic kidney disease on hemodialysis and its relationship with sociodemographic and clinical characteristics. METHODS: A cross-sectional study was carried out in a Renal Replacement Therapy Unit in the interior of the State of São Paulo involving 99 patients...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213505/planning-ability-impairments-in-probable-alzheimer-s-disease-patients-evidence-from-the-tower-of-london-test
#18
Corina Satler, Luiza Guimarães, Carlos Tomaz
Alzheimer's disease (AD) is associated with progressive impairment of higher-level cognitive abilities. Previous research suggests that early impairment of executive functions occurs during the course of the disease, but few studies have specifically investigated planning ability in an AD population. Objective: The purpose of the current study was to examine whether AD patients retain the ability to plan ahead, by analyzing specificities of their behavior in successfully achieving a pre-established goal...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213504/utility-of-the-neuropsychiatric-inventory-questionnaire-npi-q-in-the-assessment-of-a-sample-of-patients-with-alzheimer-s-disease-in-chile
#19
Gada Musa, Fernando Henríquez, Carlos Muñoz-Neira, Carolina Delgado, Patricia Lillo, Andrea Slachevsky
The Neuropsychiatric Inventory Questionnaire (NPI-Q) is an informant-based instrument that measures the presence and severity of 12 Neuropsychiatric Symptoms (NPS) in patients with dementia, as well as informant distress. Objective: To measure the psychometric properties of the NPI-Q and the prevalence of NPS in patients with Alzheimer's disease (AD) in Chile. Methods: 53 patients with AD were assessed. Subjects were divided into two different groups: mild AD (n=26) and moderate AD (n=27)...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213490/neuropathological-findings-in-entorhinal-cortex-of-subjects-aged-50-years-or-older-and-their-correlation-with-dementia-in-a-sample-from-southern-brazil
#20
Edson Rodrigues Neto, Mariana K Fonseca, Álvaro C B Guedes, Francine H Oliveira, Arlete Hilbig, Liana Lisboa Fernandez
Introduction: The aims of this study were to survey neurodegenerative changes detected by abnormal protein deposits in the Entorhinal Cortex (EC) of subjects aged 50 years or older and to correlate these findings with suspected dementia, as detected by the IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly). Methods: Fourteen brains were submitted to the immunohistochemistry technique for different proteins (beta-amyloid, tau, α-synuclein and phospho-TDP-43) and data obtained compared with IQCODE scores...
January 2017: Dementia & Neuropsychologia
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