keyword
MENU ▼
Read by QxMD icon Read
search

T. Cruzi

keyword
https://www.readbyqxmd.com/read/27921011/mechanisms-of-infectivity-and-evasion-derived-from-microvesicles-cargo-produced-by-trypanosoma-cruzi
#1
REVIEW
Bruna C Borges, Isadora A Uehara, Laysa O S Dias, Paula C Brígido, Claudio V da Silva, Marcelo J B Silva
Cell invasion by the intracellular protozoans requires interaction of proteins from both the host and the parasite. Many parasites establish chronic infections, showing they have the potential to escape the immune system; for example, Trypanosoma cruzi is an intracellular parasite that causes Chagas disease. Parasite internalization into host cell requires secreted and surface molecules, such as microvesicles. The release of microvesicles and other vesicles, such as exosomes, by different eukaryotic organisms was first observed in the late twentieth century...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27918890/differential-expression-on-mitochondrial-tryparedoxin-peroxidase-mtctxnpx-in-trypanosoma-cruzi-after-ferrocenyl-diamine-hydrochlorides-treatments
#2
Andréa A N Kohatsu, Flávia A J Silva, Acácio I Francisco, Aline Rimoldi, Marco T A Silva, Maria D Vargas, João A da Rosa, Regina M B Cicarelli
Resistance to benznidazole in certain strains of Trypanosoma cruzi may be caused by the increased production of enzymes that act on the oxidative metabolism, such as mitochondrial tryparedoxin peroxidase (mTcTXNPx) which catalyses the reduction of peroxides. This work presents cytotoxicity assays performed with ferrocenyl diamine hydrochlorides in six different strains of T. cruzi epimastigote forms (Y, Bolivia, SI1, SI8, QMII, and SIGR3). The last four strains have been recently isolated from triatominae and mammalian host (domestic cat)...
December 2, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27918574/quantitative-laser-biospeckle-method-for-the-evaluation-of-the-activity-of-trypanosoma-cruzi-using-vdrl-plates-and-digital-analysis
#3
Hilda Cristina Grassi, Lisbette C García, María Lorena Lobo-Sulbarán, Ana Velásquez, Francisco A Andrades-Grassi, Humberto Cabrera, Jesús E Andrades-Grassi, Efrén D J Andrades
In this paper we report a quantitative laser Biospeckle method using VDRL plates to monitor the activity of Trypanosoma cruzi and the calibration conditions including three image processing algorithms and three programs (ImageJ and two programs designed in this work). Benznidazole was used as a test drug. Variable volume (constant density) and variable density (constant volume) were used for the quantitative evaluation of parasite activity in calibrated wells of the VDRL plate. The desiccation process within the well was monitored as a function of volume and of the activity of the Biospeckle pattern of the parasites as well as the quantitative effect of the surface parasite quantity (proportion of the object's plane)...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27914572/different-treatment-schemes-and-dynamizations-of-trypanosoma-cruzi-biotherapies-what-information-do-they-transfer-to-the-organism-in-infected-mice
#4
Fabiana Nabarro Ferraz, Franciele Karina da Veiga, Denise Lessa Aleixo, Miguel Spack Júnior, Silvana Marques de Araújo
BACKGROUND: The use of biotherapies in Trypanosoma cruzi infection can provide an understanding about effects of these highly diluted medications. OBJECTIVES: To evaluate different treatment schemes and dynamizations of biotherapies prepared from blood trypomastigotes (buffy coat) in mice infected with T. cruzi. METHODS: Swiss mice infected with Y strain of T. cruzi were divided into two experiments. Experiment 1, all treated groups received biotherapy 7dH (10 μL/mL ad libitum) in different treatment schemes: TB7dH - treated 3 days before infection; TBA7dH - treated 3 days before and after infection; TBAe...
November 2016: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/27914221/prevalence-of-trypanosoma-cruzi-hiv-coinfection-in-southern-brazil
#5
Dulce Stauffert, Mariangela Freitas da Silveira, Marília Arndt Mesenburg, Adriane Brod Manta, Alessandra da Silva Dutra, Guilherme Lucas de Oliveira Bicca, Marcos Marreiro Villela
Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to know coinfection prevalence, a cross-sectional study of 200 HIV patients was performed between January and July 2013 in the city of Pelotas, in southern Rio Grande do Sul, an endemic area for Chagas disease. Ten subjects were found positive for T...
November 30, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27911051/sylvatic-transmission-of-trypanosoma-cruzi-among-domestic-and-wildlife-reservoirs-in-texas-usa-a-review-of-the-historical-literature
#6
REVIEW
S M Gunter, E L Brown, R Gorchakov, K O Murray, M N Garcia
Chagas disease (Trypanosoma cruzi infection) is one of the most important neglected tropical diseases affecting the Americas. The transmission dynamic of this parasite is a complicated process that involves three genera of Triatominae subfamily and over 100 known mammalian reservoirs composed of domestic, peridomestic and wildlife species. Understanding the complex relationship between vector species and mammalian hosts is important for preventing transmission to humans. We performed a historical literature review to assess the disease burden in the Texas wildlife and domestic animal population...
December 2, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27908757/synthesis-antioxidant-and-antichagasic-properties-of-a-selected-series-of-hydroxy-3-arylcoumarins
#7
Natalia Robledo-O'Ryan, Maria João Matos, Saleta Vazquez-Rodriguez, Lourdes Santana, Eugenio Uriarte, Mauricio Moncada-Basualto, Francisco Mura, Michel Lapier, Juan Diego Maya, Claudio Olea-Azar
Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent promising multifunctional agents for the delay or abolishment of the progression of this pathology. In the current work, differently substituted hydroxy-3-arylcoumarins are described, exerting both antioxidant and trypanocidal activity. Among the compounds synthesized, compound 8 showed the most interesting profile, presenting a moderate scavenging ability for peroxyl radicals (ORAC-FL=2...
November 19, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27908747/tci-tcii-and-tcvi-trypanosoma-cruzi-samples-from-chagas-disease-patients-with-distinct-clinical-forms-and-critical-analysis-of-in-vitro-and-in-vivo-behavior-response-to-treatment-and-infection-evolution-in-murine-model
#8
Maykon Tavares de Oliveira, Renata Tupinambá Branquinho, Gláucia Diniz Aléssio, Carlos Geraldo Campos Mello, Nívia Carolina Nogueira de Paiva, Cláudia Martins Carneiro, Max Jean de Ornelas Toledo, Alexandre Barbosa Reis, Olindo Assis Martins Filho, Marta de Lana
The clonal evolution of Trypanosoma cruzi sustains scientifically the hypothesis of association between parasite's genetic, biological behavior and possibly the clinical aspects of Chagas disease in patients from whom they were isolated. This study intended to characterize a range of biological properties of TcI, TcII and TcVI T. cruzi samples in order to verify the existence of these associations. Several biological features were evaluated, including in vitro epimastigote-growth, "Vero"cells infectivity and growth, along with in vivo studies of parasitemia, polymorphism of trypomastigotes, cardiac inflammation, fibrosis and response to treatment by nifurtimox during the acute and chronic murine infection...
November 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27906977/development-of-a-pcr-assay-to-detect-low-level-trypanosoma-cruzi-in-blood-specimens-collected-with-paxgene-blood-dna-tubes-for-clinical-trials-treating-chagas-disease
#9
Bo Wei, Lei Chen, Miho Kibukawa, John Kang, Hetty Waskin, Matthew Marton
Chagas disease is caused by the parasitic infection of Trypanosoma cruzi (T. cruzi). The STOP CHAGAS clinical trial was initiated in 2011 to evaluate posaconazole in treating Chagas disease, with treatment success defined as negative qualitative PCR results of detecting the parasites in blood specimens collected post-treatment. PAXgene Blood DNA tubes were utilized as a simple procedure to collect and process blood specimens. However, the PAXgene blood specimens challenged published T. cruzi PCR methods, resulting in poor sensitivity and reproducibility...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27903288/untangling-the-transmission-dynamics-of-primary-and-secondary-vectors-of-trypanosoma-cruzi-in-colombia-parasite-infection-feeding-sources-and-discrete-typing-units
#10
Carolina Hernández, Camilo Salazar, Helena Brochero, Aníbal Teherán, Luz Stella Buitrago, Mauricio Vera, Hugo Soto, Zulibeth Florez-Rivadeneira, Sussane Ardila, Gabriel Parra-Henao, Juan David Ramírez
BACKGROUND: Trypanosoma cruzi is the causative agent of Chagas disease. Due to its genetic diversity has been classified into six Discrete Typing Units (DTUs) in association with transmission cycles. In Colombia, natural T. cruzi infection has been detected in 15 triatomine species. There is scarce information regarding the infection rates, DTUs and feeding preferences of secondary vectors. Therefore, the aim of this study was to determine T. cruzi infection rates, parasite DTU, ecotopes, insect stages, geographical location and bug feeding preferences across six different triatomine species...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27902980/gene-expression-profiling-and-functional-characterization-of-macrophages-in-response-to-circulatory-microparticles-produced-during-trypanosoma-cruzi-infection-and-chagas-disease
#11
Imran H Chowdhury, Sue-Jie Koo, Shivali Gupta, Lisa Yi Liang, Bojlul Bahar, Laura Silla, Julio Nuñez-Burgos, Natalia Barrientos, Maria Paola Zago, Nisha Jain Garg
BACKGROUND: Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of clinical disease. METHODS: MPs were harvested from supernatants of human peripheral blood mononuclear cells in vitro incubated with Tc (control: LPS treated), plasma of seropositive humans with a clinically asymptomatic (CA) or symptomatic (CS) disease state (vs...
December 1, 2016: Journal of Innate Immunity
https://www.readbyqxmd.com/read/27895277/triatoma-infestans-calreticulin-gene-cloning-and-expression-of-a-main-domain-that-interacts-with-the-host-complement-system
#12
Katherine Weinberger, Norberto Collazo, Juan Carlos Aguillón, María Carmen Molina, Carlos Rosas, Jaime Peña, Javier Pizarro, Ismael Maldonado, Pedro E Cattan, Werner Apt, Arturo Ferreira
Triatoma infestans is an important hematophagous vector of Chagas disease, a neglected chronic illness affecting approximately 6 million people in Latin America. Hematophagous insects possess several molecules in their saliva that counteract host defensive responses. Calreticulin (CRT), a multifunctional protein secreted in saliva, contributes to the feeding process in some insects. Human CRT (HuCRT) and Trypanosoma cruzi CRT (TcCRT) inhibit the classical pathway of complement activation, mainly by interacting through their central S domain with complement component C1...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27891126/the-ly49e-receptor-inhibits-the-immune-control-of-acute-trypanosoma-cruzi-infection
#13
Jessica Filtjens, Nicolas Coltel, Sabrina Cencig, Sylvie Taveirne, Els Van Ammel, Aline Van Acker, Tessa Kerre, Patrick Matthys, Tom Taghon, Bart Vandekerckhove, Yves Carlier, Carine Truyens, Georges Leclercq
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase. Natural killer (NK) and NKT cells play an important role in the immune control of T. cruzi infection, mainly by releasing the cytokine IFN-γ that activates the microbicidal action of macrophages and other cells and shapes a protective type 1 immune response...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27890871/chagas-disease-in-mexico-report-of-14-cases-of-chagasic-cardiomyopathy-in-children
#14
Paz María Salazar-Schettino, Margarita Cabrera-Bravo, Clara Vazquez-Antona, Edgar Zenteno, Mariana De Alba-Alvarado, Elia Torres Gutierrez, Yolanda Guevara Gomez, María Gabriela Perera-Salazar, Guadalupe Garcia de la Torre, Martha Irene Bucio-Torres
Chagas disease is a parasitic infection mainly found in Latin America; it is transmitted by a triatomine, also known as assassin bug or kissing bug. In humans, the parasite causes mostly cardiac disorders. Two-thirds of the Mexican territory are regarded as risk areas for vector transmission of Trypanosoma cruzi, the causal agent. The parasite can be found as a blood-borne trypomastigote or as an intracellular amastigote. The progression and severity of lesions could be due to frequent reinfections or to infection by highly virulent strains...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27886451/activity-of-fluorine-containing-analogues-of-wc-9-and-structurally-related-analogues-against-two-intracellular-parasites-trypanosoma-cruzi-and-toxoplasma-gondii
#15
María N Chao, Catherine Li, Melissa Storey, Bruno N Falcone, Sergio H Szajnman, Sergio M Bonesi, Roberto Docampo, Silvia N J Moreno, Juan B Rodriguez
Two obligate intracellular parasites, Trypanosoma cruzi, the agent of Chagas disease, and Toxoplasma gondii, an agent of toxoplasmosis, upregulate the mevalonate pathway of their host cells upon infection, which suggests that this host pathway could be a potential drug target. In this work, a number of compounds structurally related to WC-9 (4-phenoxyphenoxyethyl thiocyanate), a known squalene synthase inhibitor, were designed, synthesized, and evaluated for their effect on T. cruzi and T. gondii growth in tissue culture cells...
November 25, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27876646/outcome-of-oral-infection-in-mice-inoculated-with-trypanosoma-cruzi-iv-of-the-western-brazilian-amazon
#16
Ana Paula Margioto Teston, Ana Paula de Abreu, Camila Piva Abegg, Mônica Lúcia Gomes, Max Jean de Ornelas Toledo
A new epidemiological view of American trypanosomiasis or Chagas disease has been formulated in recent decades. Oral transmission of the etiological agent of Chagas disease, Trypanosoma cruzi, has been the most common form of transmission. The T. cruzi discrete typing units TcI and TcIV have been involved in tens outbreaks of acute cases of Chagas disease in the Brazilian Amazon region. We investigated the intensity of infection in mice that were orally inoculated (OR group) with four strains of TcIV that were isolated from two outbreaks of acute Chagas disease that was orally acquired in the state of Amazonas, Brazil...
November 19, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27875909/high-hiv-trypanosoma-cruzi-coinfection-levels-in-vulnerable-populations-in-buenos-aires-argentina
#17
Andres Benchetrit, Guadalupe Andreani, Maria Mercedes Avila, Diana Rossi, Ana Maria De Rissio, Mercedes Weissenbacher, Liliana Martinez Peralta, Guillermina Dolcini
The coinfection with Trypanosoma cruzi (T. cruzi) and HIV is a relevant clinical event. The goal of this study was to establish the frequency of coinfection in populations at risk for HIV-1 in Argentina. A total of 280 HIV positive serum samples from HIV seroprevalence studies in HIV at-risk groups were tested for T.cruzi infection. Of those samples, 8 were positive for T. cruzi (coinfection rate: 2.9%); 6 of them came from HIV positive injecting drug users (IDUs) (rate: 7.8%). In view of these results, all HIV infected patients in endemic countries should undergo T...
November 22, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27872839/insight-into-the-exoproteome-of-the-tissue-derived-trypomastigote-form-of-trypanosoma-cruzi
#18
Rayner M L Queiroz, Carlos A O Ricart, Mara O Machado, Izabela M D Bastos, Jaime M de Santana, Marcelo V de Sousa, Peter Roepstorff, Sébastien Charneau
The protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cell. The secreted/excreted protein repertoire released by T. cruzi trypomastigotes is crucial in host-pathogen interactions. In this study, mammalian tissue culture-derived trypomastigotes (Y strain) were used to characterize the exoproteome of the infective bloodstream life form. Proteins released into the serum-free culture medium after 3 h of incubation were harvested and digested with trypsin...
2016: Frontiers in Chemistry
https://www.readbyqxmd.com/read/27866813/rhodnius-prolixus-from-physiology-by-wigglesworth-to-recent-studies-of-immune-system-modulation-by-trypanosoma-cruzi-and-trypanosoma-rangeli
#19
REVIEW
P Azambuja, E S Garcia, P J Waniek, C S Vieira, M B Figueiredo, M S Gonzalez, C B Mello, D P Castro, N A Ratcliffe
This review is dedicated to the memory of Professor Sir Vincent B. Wigglesworth (VW) in recognition of his many pioneering contributions to insect physiology which, even today, form the basis of modern-day research in this field. Insects not only make vital contributions to our everyday lives by their roles in pollination, balancing eco-systems and provision of honey and silk products, but they are also outstanding models for studying the pathogenicity of microorganisms and the functioning of innate immunity in humans...
November 17, 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27862705/screening-of-living-organ-donors-for-endemic-infections-understanding-the-challenges-and-benefits-of-enhanced-screening
#20
REVIEW
Amanda Rosen, Michael G Ison
Living organ donor candidates are screened for medical and psychosocial contraindications to donation. One important goal of this process is to prevent donor-derived infectious diseases transmissions. These transmissions are exceptionally rare, but have the potential to cause significant morbidity and mortality. The Organ Procurement and Transplantation Network now requires each recovery hospital to develop a protocol for evaluating living donors for tuberculosis and other geographically-defined endemic pathogens, including Trypanosoma cruzi (the causative pathogen of Chagas' disease), Strongyloides stercoralis, and West Nile Virus (WNV), in addition to universal screening for blood-borne pathogens...
November 14, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
keyword
keyword
34594
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"