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T. Cruzi

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https://www.readbyqxmd.com/read/28645772/increased-of-the-hepatocytes-and-splenocytes-apoptosis-accompanies-clinical-improvement-and-higher-survival-in-mice-infected-with-trypanosoma-cruzi-and-treated-with-highly-diluted-lycopodium-clavatum
#1
Gislaine Janaina Falkowski-Temporini, Carina Ribeiro Lopes, Paula Fernanda Massini, Camila Fernanda Brustolin, Fabiana Nabarro Ferraz, Patricia Flora Sandri, Luzmarina Hernandes, Denise Lessa Aleixo, Terezinha Fátima Barion, Luiz Gilson Esper, Silvana Marques de Araújo
Recent evidence includes apoptosis as a defense against Trypanosoma cruzi infection, which promotes an immune response in the host induced by T cells, type 1, 2 and 17. Currently, there is no medicine completely preventing the progression of this disease. We investigated the immunological and apoptotic effects, morbidity and survival of mice infected with T. cruzi and treated with dynamized homeopathic compounds 13c: Kalium causticum (GCaus), Conium maculatum, (GCon), Lycopodium clavatum (GLy) and 7% alcohol solution (control, vehicle compounds, GCI)...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28645481/subcellular-localization-of-glycolytic-enzymes-and-characterization-of-intermediary-metabolism-of-trypanosoma-rangeli
#2
Rocío Rondón-Mercado, Héctor Acosta, Ana J Cáceres, Wilfredo Quiñones, Juan Luis Concepción
Trypanosoma rangeli is a hemoflagellate protist that infects wild and domestic mammals as well as humans in Central and South America. Although this parasite is not pathogenic for human, it is being studied because it shares with Trypanosoma cruzi, the etiological agent of Chagas' disease, biological characteristics, geographic distribution, vectors and vertebrate hosts. Several metabolic studies have been performed with T. cruzi epimastigotes, however little is known about the metabolism of T. rangeli. In this work we present the subcellular distribution of the T...
June 20, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28641558/bis-2-aminoimidazolines-and-bisguanidines-synthetic-approaches-antiparasitic-activity-and-dna-binding-properties
#3
Christophe Dardonville, J Jonathan Nué Martínez
BACKGROUND: Parasitic diseases caused by protozoan parasites of the genus Trypanosoma and Plasmodium cause some of the deadliest and disabling human infections in tropical and subtropical areas. Diphenyl-based bis(2-phenylimino)imidazolidines and bisguanidines are extremely potent antiparasitic agents against Trypanosoma brucei (etiological agent of African trypanosomiasis) and Plasmodium falciparum (etiological agent of severe malaria). Many of these compounds are also curative in mouse models of stage 1 African trypanosomiasis representing promising leads for the development of antitrypanosomal drugs...
June 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28637420/bioinformatics-insights-on-targets-receptors-of-amiodarone-in-human-and-acanthamoeba-castellanii
#4
Abdul Baig, Zohaib Rana, H R Ahmad
BACKGROUND: Amiodarone is prescribed for certain cardiac arrhythmias in medical practice. The drug targets and inhibits voltage dependent sodium (Na+v), calcium (Ca+2v), potassium (K+v) channels, and enzymes like cytochrome P450 and oxidosqualene cyclase. Past studies have shown that amiodarone exerts anti-amoebic effects against Trypanosoma cruzi and Acanthamoeba castellanii. OBJECTIVES: The presence of aforementioned targets and the type of cell death induced by amiodarone in these pathogenic eukaryotes like Acanthamoeba castellanii remain to be verified...
June 21, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28620619/effects-of-1e-4e-2-methyl-1-5-bis-4-nitrophenyl-penta-1-4-dien-3-one-on-trypanosoma-cruzi-and-its-combinational-effect-with-benznidazole-ketoconazole-or-fluconazole
#5
Francieli Peron, Danielle Lazarin-Bidóia, Zia Ud Din, Edson Rodrigues-Filho, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Celso Vataru Nakamura
This study reports the activity induced by (1E,4E)-2-methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one (A3K2A3) against Trypanosoma cruzi. This compound showed trypanocidal activity against the multiplicative epimastigote and amastigote forms of this protozoan, with IC50 values of 1.99 ± 0.17 and 1.20 ± 0.16 μM, respectively, and EC50 value of 15.57 ± 0.34 μM against trypomastigotes. The combination of A3K2A3 with benznidazole or ketoconazole demonstrated strong synergism, increasing effectiveness against trypomastigotes or epimastigotes of T...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28620374/canine-macrophage-dh82-cell-line-as-a-model-to-study-susceptibility-to-trypanosoma-cruzi-infection
#6
Pedro Henrique Braz Mendonça, Raphael Francisco Dutra Barbosa da Rocha, Julliane Brito de Braz Moraes, Isabel Ferreira LaRocque-de-Freitas, Jorgete Logullo, Alexandre Morrot, Marise Pinheiro Nunes, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo
Trypanosoma cruzi is an obligatory intracellular protozoan parasite, and it is the etiological agent of Chagas' disease that is endemic in the Americas. In addition to humans, a wide spectrum of mammals can be infected by T. cruzi, including dogs. Dogs develop acute and chronic disease, similar to human infection. T. cruzi can infect almost all cell types and after cell invasion, the metacyclics trypomastigotes localize in the cytoplasm, where they transform into amastigotes, the replicative form of T. cruzi in mammals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28618210/the-non-canonical-substrates-of-trypanosoma-cruzi-tyrosine-and-aspartate-aminotransferases-branched-chain-amino-acids
#7
N C Manchola, A M Silber, C Nowicki
Trypanosoma cruzi, the etiological agent of Chagas disease, lacks genes that encode canonical branched-chain aminotransferases. However, early studies showed that when epimastigotes were grown in the presence of (14) C1 -DL-leucine, the label was incorporated into various intermediates. More recently, our studies provided evidence that T. cruzi epimastigotes display a single ATP-dependent and saturable transport system that enables epimastigotes to uptake branched-chain amino acids (BCAAs) from the culture media...
June 15, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28607099/inhibition-of-the-host-cell-lysosome-spreading-by-trypanosoma-cruzi-metacyclic-stage-specific-surface-molecule-gp90-down-regulates-parasite-invasion
#8
João Paulo Ferreira Rodrigues, Guilherme Hideki Takahashi Sant'ana, Maria Aparecida Juliano, Nobuko Yoshida
Successful infection by Trypanosoma cruzi, the agent of Chagas disease, is critically dependent on the host cell invasion by metacyclic trypomastigote (MT) forms. Two main metacyclic stage-specfic surface molecules, gp82 and gp90, play determinant roles in target cell invasion in vitro and in oral T. cruzi infection in mice. The structure and properties of gp82, which is highly conserved among T. cruzi strains, are well known. Informations on gp90 are still rather sparse. Here we attempted to fill that gap...
June 12, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28605522/seasonality-and-temperature-dependent-flight-dispersal-of-triatoma-infestans-hemiptera-reduviidae-and-other-vectors-of-chagas-disease-in-western-argentina
#9
Osvaldo Di Iorio, Ricardo E Gürtler
Flight dispersal of Triatominae is affected by climatic conditions and determines the spatiotemporal patterns of house invasion and transmission of Trypanosoma cruzi Chagas (Kinetoplastida: Trypanosomatidae). We investigated the detailed time structure and temperature dependencies of flight occurrence of Triatoma infestans Klug (Hemiptera: Reduviidae) and other triatomine species in a rural village of western Argentina by taking advantage of the attraction of adult triatomines to artificial light sources. Most of the village's streetlight posts were systematically inspected for triatomines twice between sunset and midnight over 425 nights in the spring-summer seasons of 1999-2002, an unprecedented light-trap sampling effort for any triatomine species...
June 9, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28602861/qpcr-for-the-detection-of-foodborne-trypanosoma-cruzi
#10
Poliana Alves de Souza Godoi, Claudio Adriano Piechnik, Ana Caroline de Oliveira, Michelle Zibetti Sfeir, Emanuel Maltempi de Souza, Hervé Rogez, Vanete Thomaz Soccol
Here we presented a potential real-time PCR (qPCR) method with public health importance and relevance for detection of Trypanosoma cruzi in açai pulp. There is not a current process to identify T. cruzi in açai, that ensures innocuity of this food concerning oral transmission. First, six new primers were designed using the DNA sequences of T. cruzi y152 and Emerald strains obtained from GenBank. For primers evaluation and titration they were validated regarding the amplification and not with the fluorophore chosen 1ngμL(-1) of the T...
June 8, 2017: Parasitology International
https://www.readbyqxmd.com/read/28599274/trans-sialidase-based-vaccine-candidate-protects-against-trypanosoma-cruzi-infection-not-only-inducing-an-effector-immune-response-but-also-affecting-cells-with-regulatory-suppressor-phenotype
#11
Estefanía Prochetto, Carolina Roldán, Iván A Bontempi, Daiana Bertona, Luz Peverengo, Miguel H Vicco, Luz M Rodeles, Ana R Pérez, Iván S Marcipar, Gabriel Cabrera
Prophylactic and/or therapeutic vaccines have an important potential to control Trypanosoma cruzi (T. cruzi)infection. The involvement of regulatory/suppressor immune cells after an immunization treatment and T. cruzi infection has never been addressed. Here we show that a new trans-sialidase-based immunogen (TSf) was able to confer protection, correlating not only with beneficial changes in effector immune parameters, but also influencing populations of cells related to immune control.Regarding the effector response, mice immunized with TSf showed a TS-specific antibody response, significant delayed-type hypersensitivity (DTH) reactivity and increased production of IFN-γ by CD8+ splenocytes...
May 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28598971/expression-of-inhibitory-receptors-and-polyfunctional-responses-of-t-cells-are-linked-to-the-risk-of-congenital-transmission-of-t-cruzi
#12
Adriana Egui, Paola Lasso, María Carmen Thomas, Bartolomé Carrilero, John Mario González, Adriana Cuéllar, Manuel Segovia, Concepción Judith Puerta, Manuel Carlos López
Congenital T. cruzi infections involve multiple factors in which complex interactions between the parasite and the immune system of pregnant women play important roles. In this study, we used an experimental murine model of chronic infection with T. cruzi to evaluate the changes in the expression of inhibitory receptors and the polyfunctionality of T cells during gestation and their association with congenital transmission rate of T. cruzi infection. The results showed that pregnant naïve mice had a higher percentage of CD4+ and CD8+ T cells that expressed inhibitory receptors than cells from non-pregnant naïve mice...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28595515/trans-sialidase-overcomes-many-antigens-to-be-used-as-a-vaccine-candidate-against-trypanosoma-cruzi
#13
Ivan Bontempi, Pedro Fleitas, Alexia Poato, Miguel Vicco, Luz Rodeles, Estefania Prochetto, Gabriel Cabrera, Bruno Beluzzo, Diego Arias, Andrea Racca, Sergio Guerrero, Iván Marcipar
AIM: The development of vaccines against Trypanosoma cruzi remains in an exploratory stage. Despite several antigen candidates have been evaluated, a comparison among the performance of the immunogens cannot be carried out because the available reports differ in formulations and infection model. In this work, we compared the protective capacity of seven T. cruzi antigens in the same model of five new antigens and two well-established candidates. Materials & methods: We evaluated highly immunogenic proteins that contain tandem repeats (FRA [flagelar repetitive protein], Tc3, Tc6); enzymes involved in metabolic pathways critical for parasite survival (cytosolic tryparedoxin peroxidase and tryparedoxin peroxidase); and enzymes involved in parasite invasion (trans-sialidase [TS] and cruzipain)...
June 2017: Immunotherapy
https://www.readbyqxmd.com/read/28591407/insights-from-tissue-specific-transcriptome-sequencing-analysis-of-triatoma-infestans
#14
Leilane O Gonçalves, de Oliveira Luciana M, C D'Ávila Pessoa Grasielle, Aline Cl Rosa, Marinely G Bustamante, Carlota J Belisário, Daniela M Resende, Lileia G Diotaiuti, Jeronimo C Ruiz
Triatoma infestans is an insect of subfamily Triatominae (Hemiptera: Reduviidae) and an important vector of Trypanosoma cruzi, the etiologic agent of human Chagas disease. In this work we reported a transcriptome assembly and annotation of T. infestans heads obtained by Next Generation Sequencing (NGS) technologies.
June 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28591404/sexual-transmission-of-american-trypanosomiasis-in-humans-a-new-potential-pandemic-route-for-chagas-parasites
#15
Perla F Araujo, Adriana B Almeida, Carlos F Pimentel, Adriano R Silva, Alessandro Sousa, Sebastião A Valente, Vera C Valente, Manuela M Britto, Ana C Rosa, Rozeneide M Alves, Luciana Hagström, Antonio Rl Teixeira
BACKGROUND: The Trypanosoma cruzi infection endemic in Latin America has now spread to several countries across four continents; this endemic involves triatomine vector-free protists. We hypothesised that the sexual transmission of T. cruzi contributes to the ongoing spread of Chagas disease. OBJECTIVES: A short-term longitudinal study was conducted to evaluate this hypothesis. METHODS: The study population comprised 109 subjects from four families, among whom 21 had been diagnosed with acute Chagas disease by direct parasitological analysis...
June 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28588043/heme-a-synthesis-and-c-c-o-activity-are-essential-for-trypanosoma-cruzi-infectivity-and-replication
#16
Marcelo Luciano Merli, Brenda Analía Cirulli, Simón Matías Menéndez-Bravo, Julia Alejandra Cricco
Trypanosoma cruzi , the causative agent of Chagas disease, presents a complex life cycle and adapts its metabolism to nutrients availability. Although T. cruzi is an aerobic organism, it does not produce heme. This cofactor is acquired from the host, and is distributed and inserted into different heme-proteins such as respiratory complexes in the parasite mitochondrion. It has been proposed that T. cruzi's energy metabolism relies on a branched respiratory chain with a cytochrome c oxidase type aa 3 (C c O) as the main terminal oxidase...
June 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28587855/pheophorbide-a-a-compound-isolated-from-the-leaves-of-arrabidaea-chica-induces-photodynamic-inactivation-of-trypanosoma-cruzi
#17
Nathielle Miranda, Adriana Passarella Gerola, Cláudio Roberto Novello, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Benedito Prado Dias-Filho, Noboru Hioka, João Carlos Palazzo de Mello, Celso Vataru Nakamura
BACKGROUND: Approximately 6-7 million people are infected with Trypanosoma cruzi, the etiological agent of Chagas' disease. Only two therapeutic compounds have been found to be useful against this disease: nifurtimox and benznidazole. These drugs have been effective in the acute phase of the disease but less effective in the chronic phase; they also have many side effects. Thus, the search for new compounds with trypanocidal action is necessary. Natural products can be the source of many important substances for the development of drugs to treat this infection...
June 3, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28586379/lamp-2-absence-interferes-with-plasma-membrane-repair-and-decreases-t-cruzi-host-cell-invasion
#18
Natália Fernanda Couto, Dina Pedersane, Luisa Rezende, Patrícia P Dias, Tayanne L Corbani, Lívia C Bentini, Anny C S Oliveira, Ludmila F Kelles, Thiago Castro-Gomes, Luciana O Andrade
Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, the parasite induces small injuries in the host cell membrane leading to calcium entry and lysosomal exocytosis, which are followed by compensatory endocytosis events that drive parasites into host cells. We have previously shown that absence of both LAMP-1 and 2, major components of lysosomal membranes, decreases invasion of T. cruzi into host cells, but the mechanism by which they interfere with parasite invasion has not been described...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28582629/molecular-diagnostics-for-chagas-disease-up-to-date-and-novel-methodologies
#19
Julio Alonso-Padilla, Montserrat Gallego, Alejandro G Schijman, Joaquim Gascon
Chagas disease is caused by the parasite Trypanosoma cruzi. It affects 7 million people, mainly in Latin America. Diagnosis is usually made serologically, but at some clinical scenarios serology cannot be used. Then, molecular detection is required for early detection of congenital transmission, treatment response follow up, and diagnosis of immune-suppression reactivation. However, present tests are technically demanding and require well-equipped laboratories which make them unfeasible in low-resources endemic regions...
July 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28581897/mutations-to-cysteine-residues-in-the-trypanosoma-cruzi-b-cell-superantigen-tc24-diminish-susceptibility-to-igm-mediated-hydrolysis
#20
Eric Luis Brown, Sarah Gunter, Kathryn M Jones, Christopher Seid, Heather T Essigmann, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan, Ulrich Strych
B-cell superantigens (BC-SAgs) are immunoevasins that have evolved in response to innate catalytic IgM antibodies; germ-line encoded immunoglobulins present in the preimmune repertoire independent of prior antigen exposure. Catalysis is the result of a 2-step process that involves the formation of a non-covalent bond between the BC-SAg and the immunoglobulin first followed by covalent bond formation at the catalytic site resulting in target hydrolysis. Tc24 is a recently described Trypanosoma cruzi BC-SAg hypothesized to play a role in evading the humoral response early in the infection period...
June 5, 2017: Journal of Parasitology
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