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https://www.readbyqxmd.com/read/29781553/effects-of-melatonin-on-thymic-and-oxidative-stress-dysfunctions-during-trypanosoma-cruzi-infection
#1
Vânia Brazão, Rafaela Pravato Colato, Fabricia Helena Santello, Gabriel Tavares do Vale, Natália de Almeida Gonzaga, Carlos Renato Tirapelli, José Clóvis do Prado
Although the exact etiology of Chagas' disease is not completely elucidated, thymic atrophy and oxidative stress are believed to be important contributors to the pathogenesis during acute Trypanosoma cruzi (T. cruzi) infection. We hypothethized that exogenous melatonin, administered by gavage (5 mg/kg, p.o., gavage) to young (5 weeks old) and middle-aged (18 months old) male Wistar rats would modulate thymic oxidative damage and reverse the age-related thymus regression during T. cruzi acute infection. Increased levels of superoxide anion (O2 - ) were detected in the thymus of infected animals and treatment with melatonin reverted this response...
May 21, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29778329/the-kinetoplast-dna-of-the-australian-trypanosome-trypanosoma-copemani-shares-features-with-trypanosoma-cruzi-and-trypanosoma-lewisi
#2
Adriana Botero, Irit Kapeller, Crystal Cooper, Peta L Clode, Joseph Shlomai, R C Andrew Thompson
Kinetoplast DNA (kDNA) is the mitochondrial genome of trypanosomatids. It consists of a few dozen maxicircles and several thousand minicircles, all catenated topologically to form a two-dimensional DNA network. Minicircles are heterogeneous in size and sequence among species. They present one or several conserved regions that contain three highly conserved sequence blocks (CSBs). CSB-1 (10 bp sequence) and CSB-2 (8 bp sequence) present lower interspecies homology, while CSB-3 (12 bp sequence) or the Universal Minicircle Sequence (UMS) is conserved within most trypanosomatids...
May 17, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29775566/the-challenge-of-discordant-serology-in-chagas-disease-the-role-of-two-confirmatory-techniques-in-inconclusive-cases
#3
Zaira Moure, Elena Sulleiro, Laura Iniesta, Carmen Guillen, Israel Molina, M Magdalena Alcover, Cristina Riera, Tomás Pumarola, Roser Fisa
Serodiscordance in Chagas disease (CD) remains a challenge since individuals with inconclusive results are clinically complicated to manage. This work, conducted outside the endemic area, aims to compare two different confirmatory techniques for the diagnosis of CD in individuals without a definitive diagnosis, to analyze the performance of the screening techniques in this group of patients, and to describe the serological follow-up of these subjects over time. Sera from 48 individuals with repeatedly discordant results by one recombinant enzyme immunoassay (r-ELISA) and one native ELISA (n-ELISA), were included in the study...
May 15, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29774028/nlrp3-inflammasome-and-caspase-1-11-pathway-orchestrate-different-outcomes-in-the-host-protection-against-trypanosoma-cruzi-acute-infection
#4
Augusto F Paroli, Patricia V Gonzalez, Cintia Díaz-Luján, Luisina I Onofrio, Alfredo Arocena, Roxana C Cano, Eugenio A Carrera-Silva, Susana Gea
Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. Considering that inflammasome activation and IL-1β induction by macrophages are key players for an appropriate T cell response, we investigated the relevance of NLR pyrin domain-containing 3 (NLRP3) and caspase-1/11 to elucidate their roles in the induction of different T cell phenotypes and the relationship with parasite load and hepatic inflammation during T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29768552/natural-infection-by-trypanosoma-cruzi-in-triatomines-and-seropositivity-for-chagas-disease-of-dogs-in-rural-areas-of-rio-grande-do-norte-brazil
#5
Yannara Barbosa Nogueira Freitas, Celeste da Silva Freitas de Souza, Jamille Maia E Magalhães, Maressa Laíse Reginaldo de Sousa, Luiz Ney d'Escoffier, Tânia Zaverucha do Valle, Teresa Cristina Monte Gonçalves, Hélcio Reinaldo Gil-Santana, Thais Aaparecida Kazimoto, Sthenia Santos Albano Amora
INTRODUCTION: Chagas disease is caused by the protozoa Trypanosoma cruzi. Its main reservoir is the domestic dog, especially in rural areas with favorable characteristics for vector establishment and proliferation. The aims of this study were to collect data, survey and map the fauna, and identify T. cruzi infection in triatomines, as well as to assess the presence of anti-T. cruzi antibodies in dogs in rural areas of the municipality of Mossoró, Brazil. METHODS: An active entomologic research was conducted to identify adult specimens through an external morphology dichotomous key...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768550/insect-vectors-of-chagas-disease-trypanosoma-cruzi-in-northeastern-brazil
#6
Arduina Sofia Ortet de Barros Vasconcelos Fidalgo, Alanna Carla da Costa, José Damião da Silva Filho, Darlan da Silva Cândido, Erlane Chaves Freitas, Laíse Dos Santos Pereira, Mônica Coelho de Andrade, Kátia Cristina Morais Soares Gomes, Cláudia Mendonça Bezerra, Maria de Fátima Oliveira
INTRODUCTION: Chagas disease remains a public health problem in the rural and urban areas of 19 countries in the Americas. METHODS: The aim of the present study was to investigate the Trypanosoma cruzi infection rate of triatomines collected from both intra- and peridomiciliary areas in eleven municipalities of Southeastern Ceará, Brazil, from 2009 to 2015. RESULTS: A total of 32,364 triatomine specimens, including nymphs and adults, were collected, and 31,736 (98...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768544/response-to-different-benznidazole-doses-in-animal-models-of-chronic-phase-chagas-disease-a-critical-review
#7
Cauê Benito Scarim, Aline Rimoldi Ribeiro, João Aristeu da Rosa, Chung Man Chin
Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective, existing, experimental chronic protocols that can be used for comparison purposes. Here, we present a literature review regarding experimental models with chronic Chagas disease to evaluate the efficacy of benznidazole (BZN)...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768103/efficacy-of-recombinase-polymerase-amplification-to-diagnose-trypanosoma-cruzi-infection-in-dogs-with-cardiac-alterations-from-an-endemic-area-of-mexico
#8
Matilde Jimenez-Coello, Thomas Shelite, Alejandro Castellanos-Gonzalez, Omar Saldarriaga, Rocio Rivero, Antonio Ortega-Pacheco, Carlos Acevedo-Arcique, Karla Amaya-Guardia, Nisha Garg, Peter Melby, Bruno L Travi
Chagas disease is a lingering Public Health problem in Latin America with ∼5.7 million people infected with Trypanosoma cruzi. Transmission is still taking place in most countries of the Americas, including the United States. Dogs are frequently infected with T. cruzi and its high infection prevalence is associated with increased risk of Chagas disease in humans. The city of Mérida in the Yucatan peninsula is endemic for Chagas disease and canines are frequently infected with T. cruzi. The objective of this study was to evaluate the performance of a qualitative point of care (POC) molecular test (RPA-LF, recombinase polymerase amplification-lateral flow) developed in our laboratory for identifying infected dogs...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29755558/antiparasitic-activity-and-essential-oil-chemical-analysis-of-the-piper-tuberculatum-jacq-fruit
#9
Valterlúcio Dos Santos Sales, Álefe Brito Monteiro, Gyllyandeson de Araújo Delmondes, Emmily Petícia do Nascimento, Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo, Cristina Kelly de Souza Rodrigues, Josefa Fernanda Evangelista de Lacerda, Cícera Norma Fernandes, Maysa de Oliveira Barbosa, Adamo Xenofonte Brasil, Saulo Relison Tintino, Maria Celeste Vega Gomez, Cathia Coronel, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf
With the increase of neglected diseases such as leishmaniasis and Chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. Thus, this study was performed to investigate the antiparasitic activity of the essential oil from the fruits of Piper tuberculatum Jacq, against lines of Leishmania braziliensis (MHOM/CO/88/UA301), Leishmania infantum (MHOM/ES/92/BCN83) and Trypanosoma cruzi (LC-B5 clone). Before running protocols, an analysis of the chemical composition of essential oil was conducted, which presented monoterpenes and sesquiterpenes...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29755471/extracellular-vesicles-shed-by-trypanosoma-cruzi-potentiate-infection-and-elicit-lipid-body-formation-and-pge-2-production-in-murine-macrophages
#10
Maria Isabel Lovo-Martins, Aparecida Donizette Malvezi, Nágela Ghabdan Zanluqui, Bruno Fernando Cruz Lucchetti, Vera Lúcia Hideko Tatakihara, Patricia Alves Mörking, Admilton Gonçalves de Oliveira, Samuel Goldenberg, Pryscilla Fanini Wowk, Phileno Pinge-Filho
During the onset of Trypanosoma cruzi infection, an effective immune response is necessary to control parasite replication and ensure host survival. Macrophages have a central role in innate immunity, acting as an important trypanocidal cell and triggering the adaptive immune response through antigen presentation and cytokine production. However, T. cruzi displays immune evasion mechanisms that allow infection and replication in macrophages, favoring its chronic persistence. One potential mechanism is the release of T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29750791/impact-of-benznidazole-treatment-on-the-functional-response-of-trypanosoma-cruzi-antigen-specific-cd4-cd8-t-cells-in-chronic-chagas-disease-patients
#11
Elena Pérez-Antón, Adriana Egui, M Carmen Thomas, Concepción J Puerta, John Mario González, Adriana Cuéllar, Manuel Segovia, Manuel Carlos López
BACKGROUND: Chagas disease is caused by Trypanosoma cruzi. The persistence of the parasite is associated with the disease chronicity and the impairment of the cellular immune response. It has been reported that the CD4+CD8+ T cell population expands in chronic Chagas disease patients. Few studies have focused on this subset of cells, and very little is known about the impact of antiparasitic treatment on this population. METHODOLOGY: Thirty-eight chronic Chagas disease patients (20 asymptomatic and 18 symptomatic) and twelve healthy controls were enrolled in this study...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29746872/the-contribution-of-the-dna-microarray-technology-to-gene-expression-profiling-in-leishmania-spp-a-retrospective
#12
REVIEW
Ana Alonso, Vicente Larraga, Pedro J Alcolea
The first genome project of any living organism excluding viruses, the gammaproteobacteria Haemophilus influenzae, was completed in 1995. Until the last decade, genome sequencing was very tedious because genome survey sequences (GSS) and/or expressed sequence tags (ESTs) belonging to plasmid, cosmid and artificial chromosome genome libraries had to be sequenced and assembled in silico. Nowadays, no genome is completely assembled actually, because gaps and unassembled contigs are always remaining. However, most represent the whole genome of the organism of origin from a practical point of view...
May 7, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29745731/helietta-apiculata-a-tropical-weapon-against-chagas-disease
#13
Maria Elena Ferreira, Antonieta Rojas de Arias, Gloria Yaluff, Ninfa Vera de Bilbao, Hector Nakayama, Susana Torres, Alicia Schinini, Susana Torres, Elva Serna, Ana Claudia Torrecilhas, Alain Fournet, Gerardo Cebrián-Torrejón
The present study pretends to evaluate the in vivo efficacy of the crude chloroform bark extract of Helietta apiculata, then the activity will be compared with the reference drug, benznidazole, in acute Trypanosoma cruzi infected mice when administered by oral route. The chloroformic extract of Helieta apiculata was administered by oral route at 5, 10 and 50 mg/kg daily for two weeks. This study has shown a moderate efficacy of the H. apiculata bark extract in reducing T. cruzi parasitaemia in 42 to 54% after a monitoring of 60 days post-infection and when compared with control groups...
May 10, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29745031/trypanosoma-cruzi-biochemical-changes-and-cell-death-induced-by-an-organometallic-platinum-based-compound
#14
M Florencia Mosquillo, Lucía Bilbao, Fabricio Hernández, Florencia Tissot, Dinorah Gambino, Beatriz Garat, Leticia Pérez-Díaz
Chagas disease is an endemic illness in Latin America caused by the parasite Trypanosoma cruzi. Current chemotherapies are old and inadequate, and the emergence of drug resistant strains underscores the need of new drugs. Platinum-based complexes have been shown to be a promising approach against parasitic diseases. In this work, the effect of 1,1'-bis(diphenylphosphino)ferrocene pyridine-2-thiolate-1-oxide Pt(II) hexafluorophosphate, Pt-dppf-mpo, was studied on T. cruzi. A promising anti-trypanosomal activity was determined for the CL Brener strain with a low cytotoxicity determined using in vitro cultured mammal cells...
May 9, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29744939/heart-transplant-outcomes-in-patients-with-chagas-cardiomyopathy-in-the-united-states
#15
Rodolfo D Benatti, Sadeer G Al-Kindi, Fernando Bacal, Guilherme H Oliveira
BACKGROUND: Chagas cardiomyopathy (CC) is one of the chronic manifestations of Trypanosoma cruzi (T. cruzi) infection and is among the leading reasons for heart transplantation (HT) in Latin America. Chagas disease is also present in areas with large Hispanic communities in the United States. Our objective is to evaluate the outcomes of cardiac allograft recipients with the diagnosis of CC in the United States. METHODS AND RESULTS: We identified 25 adult patients with CC and 15,930 with idiopathic dilated cardiomyopathy (IDCMP) who underwent HT between 1987 and 2015...
May 9, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29743880/-trypanosoma-cruzi-exploits-wnt-signaling-pathway-to-promote-its-intracellular-replication-in-macrophages
#16
Ximena Volpini, Laura F Ambrosio, Laura Fozzatti, Constanza Insfran, Cinthia C Stempin, Laura Cervi, Claudia Cristina Motran
During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication and instruct an appropriate adaptive response. Recently, it has become evident that Wnt signaling has immunomodulatory functions during inflammation and infection. Here, we tested the hypothesis that during T. cruzi infection, the activation of Wnt signaling pathway in macrophages plays a role in modulating the inflammatory/tolerogenic response and therefore regulating the control of parasite replication...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29741138/insights-into-anti-trypanosomal-agents-based-on-synthetic-glycoconjugates
#17
Vanessa Leiria Campo, Marcelo Fiori Marchiori, Ivone Carvalho
Chagas disease is still a worldwide threat, with estimated 6 to 7 million infected people, mainly in Latin America. Current treatments still rely only on benznidazol and nifurtimox, drugs with poor efficacy in chronic infection phase and recognized toxicity. Thus, there is an urgent need for new therapeutic agents against this disease. In this review we present an updated selection over the last decade of synthetic glycoconjugates as anti-trypanosomal agents, properly addressed as monosaccharide- and disaccharide-based agents, and multivalent-based derivatives, disclosing relevant methods for their synthesis, along with their activities on T...
May 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29739357/serological-evaluation-for-chagas-disease-in-migrants-from-latin-american-countries-resident-in-rome-italy
#18
Stefania Pane, Maria Letizia Giancola, Pierluca Piselli, Angela Corpolongo, Ernestina Repetto, Rita Bellagamba, Claudia Cimaglia, Stefania Carrara, Piero Ghirga, Alessandra Oliva, Nazario Bevilacqua, Ahmad Al Rousan, Carla Nisii, Giuseppe Ippolito, Emanuele Nicastri
BACKGROUND: Chagas disease (CD) is a systemic parasitic infection caused by the protozoan Trypanosoma cruzi, whose chronic phase may lead to cardiac and intestinal disorders. Endemic in Latin America where it is transmitted mainly by vectors, large-scale migrations to other countries have turned CD into a global health problem because of its alternative transmission routes through blood transfusion, tissue transplantation, or congenital. Aim of this study was to compare the performance of two commercially available tests for serological diagnosis of CD in a group of Latin American migrants living in a non-endemic setting (Rome, Italy)...
May 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29736822/immunogenomic-screening-approach-to-identify-new-antigens-for-the-serological-diagnosis-of-chronic-chagas-disease
#19
Rutyanne Maria Tonelli Elisei, Christiane Santos Matos, Ana Maria Ravena Severino Carvalho, Ana Thereza Chaves, Fernanda Alvarenga Cardoso Medeiros, Ronaldo Barbosa, Andreza Pain Marcelino, Kenia Dos Santos Emidio, Eduardo Antonio Ferraz Coelho, Mariana Costa Duarte, Tiago Antônio de Oliveira Mendes, Manoel Otávio da Costa Rocha, Daniel Menezes-Souza
Serological tests are preferentially used for the diagnosis of Chagas' disease (CD) during the chronic phase because of the low parasitemia and high anti-Trypanosoma cruzi antibody titers. However, the current methods showed several disadvantages, as contradictory or inconclusive results, mainly related to the characteristics of the antigens used, in general, crude or whole parasites, but also due to antigen production protocol and the experimental conditions used in serological tests. Thus, better-quality serological assays are urgently needed...
May 7, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29733902/paradoxical-effects-of-vitamin-c-in-chagas-disease
#20
J R P T Castanheira, R E P Castanho, H Rocha, C Pagliari, M I S Duarte, A L S Therezo, E F B Chagas, L P A Martins
Trypanosoma cruzi infection stimulates inflammatory mediators which cause oxidative stress, and the use of antioxidants can minimize the sequelae of Chagas disease. In order to evaluate the efficacy of vitamin C in minimizing oxidative damage in Chagas disease, we orally administered ascorbic acid to Swiss mice infected with 5.0 × 104 trypomastigote forms of T. cruzi QM2 strain. These animals were treated for 60 days to investigate the acute phase and 180 days for the chronic phase. During the acute phase, the animals in the infected and treated groups demonstrated lower parasitemia and inflammatory processes were seen in more mice in these groups, probably due to the higher concentration of nitric oxide, which led to the formation of peroxynitrite...
May 4, 2018: Parasitology International
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