keyword
https://read.qxmd.com/read/38536824/copayment-mechanism-in-selected-districts-of-uganda-availability-market-share-and-price-of-quality-assured-artemisinin-based-combination-therapies-in-private-drug-outlets
#1
JOURNAL ARTICLE
Moses Ocan, Winnie Nambatya, Caroline Otike, Loyce Nakalembe, Sam Nsobya
BACKGROUND: Malaria remains one of the leading causes of morbidity, and mortality in Uganda. A large proportion of malaria symptomatic patients seek healthcare in private sector. However, availability and affordability are major barriers to access to effective treatment. The private sector copayment mechanism in Uganda aims to increase availability and affordability of antimalarial agents. Our study assessed availability, price, and market share of quality assured artemisinin-based combination therapies (QAACTs) in private drug outlets in selected districts during the implementation of copayment mechanism...
2024: PloS One
https://read.qxmd.com/read/38536660/comparative-assessment-of-drug-lag-for-approved-oncology-targeted-therapies-between-saudi-arabia-the-united-states-and-the-european-union
#2
JOURNAL ARTICLE
Mohammed Alnuhait, Abdullah Alshammari, Manar Alharbi, Lina AlOtaibi, Reem Alharbi, Attiah Khobrani, Nora Alkhudair, Majed Alshamrani, Abdullah M Alrajhi
INTRODUCTION: Pharmaceutical regulation on a global scale is a complex process, with regulatory bodies overseeing various aspects, including licensing, registration, manufacturing, marketing, and labeling. Among these, the USFDA plays a crucial role in upholding public health. The pharmaceutical industry contributes significantly to well-being by developing and distributing therapeutic agents. The journey of evaluating new pharmaceuticals involves meticulous examination through several phases, from safety and efficacy assessments to toxicity evaluation...
March 27, 2024: Therapeutic Innovation & Regulatory Science
https://read.qxmd.com/read/38533680/determination-of-procoagulant-activity-in-human-normal-immunoglobulin-preparations-for-therapeutic-use-by-fxia-chromogenic-assay-evaluation-of-test-kit-sensitivity-reference-standard-performance-and-product-formulation-effects-on-the-fxia-assay
#3
JOURNAL ARTICLE
M-E Behr-Gross, D Le Tallec, N Sinitskaya, C Milne, M Etscheid
In 2010, the reporting of thrombotic adverse events for one subcutaneous and certain intravenous immunoglobulins (IGs) raised some concerns. In Europe, regulatory bodies rapidly revised compendial specifications for therapeutic IGs to ensure they do not exhibit thrombogenic (procoagulant) activity (PCA). At the global level, a working group (GWG) was launched with the aim of assessing PCA measurement methods and limits, considering results obtained by human IG manufacturers during in-process controls. The GWG created three dedicated subgroups to investigate the FXIa chromogenic assay, the non-activated partial thromboplastin time (NAPTT) test and the thrombin generation assay (TGA)...
2024: Pharmeuropa Bio & Scientific Notes
https://read.qxmd.com/read/38531542/how-far-can-reformulation-participate-in-improving-the-nutritional-quality-of-diets-at-population-level-a-modelling-study-using-real-food-market-data-in-france
#4
JOURNAL ARTICLE
Barthélémy Sarda, Emmanuelle Kesse-Guyot, Bernard Srour, Mélanie Deschasaux-Tanguy, Morgane Fialon, Léopold K Fezeu, Pilar Galan, Serge Hercberg, Mathilde Touvier, Chantal Julia
BACKGROUND: Food reformulation is promoted as a tool to improve the nutritional quality of population diets. However, the potential impact of industry-wide reformulation on dietary intake has been investigated minimally. OBJECTIVES: The aim was to estimate the impact on the French population nutrient intakes of industry-wide reformulation towards healthier products using the updated nutrient profiling system underpinning the front-of-pack nutrition label Nutri-Score (uNS-NPS)...
March 25, 2024: BMJ Global Health
https://read.qxmd.com/read/38530422/-role-of-social-medicine-within-the-german-federal-employment-agency
#5
REVIEW
Hubert G Hotz
Social medicine deals with the interrelationships between health and society-as a cross-sectional subject within medicine and a bridging subject at the interfaces to other specialist disciplines. In the public and within the health system, social medicine still does not receive the attention it should be given, despite to its medical and socioeconomic importance. A significant proportion of social medicine specialists in Germany work as experts for social security providers. Using the example of the Medical Specialist Service ("Ärztlichen Dienstes", ÄD) of the German Federal Employment Agency ("Bundesagentur für Arbeit", BA), the medical tasks in social medicine are outlined...
March 26, 2024: Dermatologie (Heidelb)
https://read.qxmd.com/read/38529182/shotgun-metagenomics-reveals-the-gut-microbial-diversity-and-functions-in-vespa-mandarinia-hymenoptera-vespidae-at-multiple-life-stages
#6
JOURNAL ARTICLE
Peng-Kai Yin, Huai Xiao, Zhi-Bin Yang, Da-Song Yang, Yin-He Yang
Wasps play important roles as predators and pollinators in the ecosystem. The Jingpo minority residing in Yunnan Province, China, has a traditional practice of using wine infused with mature wasps as a customary remedy for managing rheumatoid arthritis. The larva of the wasp is also a tasteful folk dish that has created a tremendous market. There is a paucity of survival knowledge, which has greatly restricted their potential applications in food and healthcare. Recent research has highlighted the importance of gut microbiota in insect growth...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38527076/parenteral-nutrition-at-home-long-term-parenteral-nutrition
#7
JOURNAL ARTICLE
Vanessa J Kumpf, Brenda Gray, Jessica Monczka, Sarah Zeraschi, Stanislaw Klek
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Some diseases require that patients receive parenteral nutrition (PN) over a prolonged time period...
March 25, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38525730/timely-cheap-or-risk-free-the-effect-of-regulation-on-the-price-and-availability-of-new-drugs
#8
JOURNAL ARTICLE
Laura Levaggi, Rosella Levaggi
The high level of regulation of innovative drugs on the market, which is necessary to protect consumers, produces important effects on drug availability and innovation. In public healthcare systems, the need to curb prices comes from expenditure considerations. The aim of price regulation is to obtain a more equitable allocation of the value of an innovative drug between industries and patients (by reducing prices to make drugs more affordable), but it may also reduce access. (In the listing process, the industry may find it more convenient to limit commercialisation to profitable subgroups of patients...
March 18, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38522368/finding-value-in-novel-antibiotics-how-can-infectious-diseases-adopt-incremental-cost-effectiveness-to-improve-new-antibiotic-utilization
#9
JOURNAL ARTICLE
Sean R Van Helden, Lucas T Schulz, Megan Wimmer, Victoria L Cancelliere, Warren E Rose
Research and development of innovative antimicrobials is paramount to addressing the antimicrobial resistance threat. Although antimicrobial discovery and development has increased, difficulties have emerged in the pharmaceutical industry after market approval. In this minireview, we summarize clinical trial data on recently approved antibiotics, calculate incremental cost-effectiveness ratio (ICER) values, and explore ways to adapt ICER calculations to the limitations of antimicrobial clinical trial design...
March 8, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38519756/an-emerging-zoonosis-molecular-detection-of-multidrug-methicillin-resistant-staphylococcus-aureus-from-butchers-knives-livestock-products-and-contact-surfaces
#10
JOURNAL ARTICLE
Dauda Dauda Ibrahim, Simon Ikechukwu Enem, Godwin Egwu, David Dantong, Kelvin Olutimilehin Jolayemi, Mohammed Sani Gaddafi
Methicillin-resistant Staphylococcus aureus (MRSA) transmission in livestock, community, and healthcare settings poses a significant public health concern both locally and globally. This study aimed to investigate the occurrence, molecular detection, and antibiogram of the MRSA strain in fresh beef, contact surfaces, and butchers' knives from the four major abattoirs (Karu, Gwagwalada, Deidei, and Kubwa) located in the Federal Capital Territory, Nigeria. A multi-stage sampling technique was used to collect 400 swab samples from butchers' knives (132), fresh beef (136), and contact surfaces (132)...
March 23, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38518482/financial-burden-of-medicines-in-five-northern-european-countries-a-decommodification-perspective
#11
JOURNAL ARTICLE
Katri Aaltonen, Maria Vaalavuo
Affordable access to healthcare including medicines is a key social policy goal in Europe. However, it has rarely been addressed in comparative social policy research. Although the concept of decommodification has already been used in the context of healthcare and sickness benefits, we argue that the scope of such studies should be expanded to medicines to understand how welfare states protect their citizens from market forces in case of illness. We examine and compare the relationship between income, other characteristics, and subjective financial burden of medicines (FBM) across five countries with universal health systems pursuing egalitarian aims (Denmark, Finland, the Netherlands, Norway and Sweden)...
March 19, 2024: Social Science & Medicine
https://read.qxmd.com/read/38513199/the-aotearoa-new-zealand-doctor-shortage-current-context-and-strategies-for-retention
#12
EDITORIAL
Eva G D Hitchon, Kate Eggleston, Roger Mulder, Richard Porter, Katie Douglas
The international migration of health professionals has been an ongoing issue with the medical workforce in Aotearoa New Zealand. There are many reasons why New Zealand-trained doctors choose to leave. Often it has been to gain overseas experience, with many eventually returning to New Zealand; however, this has now changed, with increasing numbers not returning. Little has been done to combat this developing problem, amidst an increasingly competitive global market for health professionals. There is public and political concern about the current shortage and uneven distribution of doctors, particularly because this has fostered unsustainable working conditions, which diminishes the provision of safe healthcare in this country...
March 22, 2024: New Zealand Medical Journal
https://read.qxmd.com/read/38512638/analyzing-the-20-year-declining-trend-of-hospital-length-of-stay-in-european-countries-with-different-healthcare-systems-and-reimbursement-models
#13
JOURNAL ARTICLE
Davide Golinelli, Francesco Sanmarchi, Fabrizio Toscano, Andrea Bucci, Nicola Nante
The study aims to investigate the last 20-year (2000-2019) of hospital length of stay (LOS) trends and their association with different healthcare systems (HS) among 25 European countries. A panel dataset was created using secondary data from Eurostat and Global Burden of Disease study databases, with dependent and control variables aggregated at the national level over a period of 20 years. A time trend analysis was conducted using a weighted least squares model for panel data to investigate the association between LOS, HS models [National Health Service (NHS), National Health Insurance, Social Health Insurance (SHI), and Etatist Social Health Insurance], healthcare reimbursement schemes [Prospective Global Budget (PGB), Diagnosis Related Groups (DRG), and Procedure Service Payment (PSP)], and control variables...
March 21, 2024: International Journal of Health Economics and Management
https://read.qxmd.com/read/38512073/diabetes-a-review-of-its-pathophysiology-and-advanced-methods-of-mitigation
#14
REVIEW
Sarika Gupta, Nitin Sharma, Sandeep Arora, Saurabh Verma
Diabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated with one or more diseases like cardiovascular disease, liver disorder, or kidney malfunction...
March 21, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38506485/a-benefit-risk-conceptual-framework-for-biologic-use-during-pregnancy-a-mini-review
#15
REVIEW
Laura M Bozzi, Melanie H Jacobson, Emily Yost, Anna Sheahan, Joseph Cafone, Yosuke Komatsu, Lisa Schwartz, Bennett Levitan, Robert M Nelson
Recent reports related to in utero exposure of marketed immunosuppressive biologics led to clinical recommendations to delay live vaccinations for infants due to the concern of reduced vaccine effectiveness and/or increased risk of vaccine-related disease. These delays can increase the risk of children contracting vaccine preventable diseases, yet the alternative cessation of biologics during pregnancy may result in increased autoimmune disease activity for the pregnant person, raising complex benefit-risk (B-R) considerations and trade-offs...
March 20, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38505353/job-demands-and-mental-health-deterioration-investigating-the-mediating-role-of-resiliency
#16
JOURNAL ARTICLE
Wei Han
INTRODUCTION: In the past decade, China has witnessed a significant surge in the popularity of food delivery apps, with its industry now thrice the size of the U.S, employing approximately 7 million drivers navigating urban landscapes on electric bikes and scooters. Predominantly, the market is governed by two main players: Meituan Dianping (backed by Tencent) and Ele.me (supported by Alibaba). Notably, stress and absenteeism stand out as significant challenges in this service sector, with implications for occupational health that translate into considerable costs for both healthcare systems and companies...
2024: Psychology Research and Behavior Management
https://read.qxmd.com/read/38504455/clinically-relevant-herb-drug-interactions-a-30-year-historical-assessment
#17
REVIEW
Bill J Gurley
The Dietary Supplement Health and Education Act, a legislative measure ushering in a novel class of complementary healthcare products known as dietary supplements, will mark its 30th anniversary in October 2024. Over this 30-year period, dietary supplement usage evolved from a few hundred products made up mostly of vitamins, minerals, and select botanical extracts to more than 75,000 single- and multi-ingredient products that are now regular staples in the American healthcare system and used by half of all U...
March 19, 2024: Journal of Dietary Supplements
https://read.qxmd.com/read/38501272/preferences-of-healthcare-providers-in-switzerland-for-attributes-of-pediatric-hexavalent-vaccines-a-discrete-choice-experiment
#18
JOURNAL ARTICLE
Salome Samant, Susanne Oberle, Tomas Marcek, Christine Poulos, Phani Chintakayala, Edith Langevin, Tanaz Petigara, Marco Boeri
OBJECTIVE: To understand the preferences of healthcare providers (HCPs) in Switzerland for pediatric hexavalent vaccine attributes. METHODS: A discrete-choice experiment included a series of choices between 2 hypothetical pediatric hexavalent vaccines with varying attributes: device type (including preparation time and risk of dosage errors), proportion of infants seroprotected against Haemophilus influenzae type b (Hib) at 11-12 months (pre-booster), packaging size, years on the market, and the thermostability at room temperature...
March 19, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38499984/smoothing-consumption-in-times-of-illness-household-recourse-mechanisms
#19
JOURNAL ARTICLE
Abhishek Dureja, Digvijay S Negi
We study the welfare impacts of illness shocks on rural agricultural households in the semi-arid tropical and humid eastern regions of India. These regions are characterized by rainfed agriculture, missing markets for credit and insurance, and limited access to publicly funded healthcare infrastructure. We find that illness shocks increase households' medical expenditures and reduce wage income. However, aggregate non-medical, food, and non-food consumption expenditures are insensitive to illness shocks. Disaggregating illness by the age and the gender of the household members, we observe that illness in male children leads to the largest increase in medical expenditure, and illness in prime-aged adults leads to the largest decline in per-capita wage earnings...
March 18, 2024: Health Economics
https://read.qxmd.com/read/38499187/institutional-micro-cost-comparative-analysis-of-reusable-vs-single-use-cystoscopes-with-assessment-of-environmental-footprint
#20
JOURNAL ARTICLE
Riccardo Bertolo, Veronica Gilioli, Alessandro Veccia, Sarah Malandra, Luca Dal Corso, Daniela Fenzi, Francesca Mazzetto, Alessandro Antonelli
OBJECTIVE: To conduct a comparative cost analysis between single-use and reusable cystoscopes from a national healthcare system perspective and assess the environmental footprint. METHODS: Single-center micro-cost analysis of reusable versus single-use cystoscopes used institutional data. The cost breakdown included capital, reprocessing, repair, procedure, and environmental impact expenses. Data collection occurred in 2022, utilizing register data, observations, and expert opinions...
March 16, 2024: Urology
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