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https://www.readbyqxmd.com/read/27923765/better-together-strategies-based-on-magnetic-particles-and-quantum-dots-for-improved-biosensing
#1
REVIEW
Laura Moro, Mehmet Turemis, Bruna Marini, Rudy Ippodrino, Maria Teresa Giardi
Novel technologies and strategies for sensitive detection of biological responses in healthcare, food and environmental monitoring continue to be a priority. The present review focuses on bioassay development based on the simultaneous use of quantum dots and magnetic beads. Due to the outstanding characteristics of both particles for biosensing applications and the large number of publications using a combined approach, we aim to provide a comprehensive overview of the literature on different bioassays, the most recent advances and innovative strategies on the topic, together with an analysis of the main drawbacks encountered and potential solutions offered, with a special emphasis on the requirements that the transfer of technologies from the laboratory to the market will demand for future commercialization ofbiodevices...
December 3, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27919225/comparison-of-the-first-three-waves-of-avian-influenza-a-h7n9-virus-circulation-in-the-mainland-of-the-people-s-republic-of-china
#2
Nijuan Xiang, A Danielle Iuliano, Yanping Zhang, Ruiqi Ren, Xingyi Geng, Bili Ye, Wenxiao Tu, Ch Ao Li, Yong Lv, Ming Yang, Jian Zhao, Yali Wang, Fuqiang Yang, Lei Zhou, Bo Liu, Yuelong Shu, Daxin Ni, Zijian Feng, Qun Li
BACKGROUND: H7N9 human cases were first detected in mainland China in March 2013. Circulation of this virus has continued each year shifting to typical winter months. We compared the clinical and epidemiologic characteristics for the first three waves of virus circulation. METHODS: The first wave was defined as reported cases with onset dates between March 31-September 30, 2013, the second wave was defined as October 1, 2013-September 30, 2014 and the third wave was defined as October 1, 2014-September 30, 2015...
December 5, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27917479/hospital-postacute-care-referral-networks-is-referral-concentration-associated-with-medicare-style-bundled-payments
#3
Ramandeep Kaur, Jennifer N Perloff, Christopher Tompkins, Christine E Bishop
OBJECTIVE: To evaluate whether Medicare-style bundled payments are lower or higher for beneficiaries discharged from hospitals with postacute care (PAC) referrals concentrated among fewer PAC providers. DATA SOURCE: Medicare Part A and Part B claim (2008-2012) for all beneficiaries residing in any of 17 market areas: the Provider of Service file, the Healthcare Cost Report Information System, and the Dartmouth Atlas. STUDY DESIGN: An observational study in which hospitals were distinguished according to PAC referral concentration, which is the tendency to utilize fewer rather than more PAC providers...
December 5, 2016: Health Services Research
https://www.readbyqxmd.com/read/27910120/at-the-margins-of-biomedicine-the-ambiguous-position-of-registered-medical-practitioners-in-rural-indian-healthcare
#4
Papreen Nahar, Nanda Kishore Kannuri, Sitamma Mikkilineni, G V S Murthy, Peter Phillimore
This analysis challenges a tendency in public health and the social sciences to associate India's medical pluralism with a distinction between biomedicine, as a homogeneous entity, and its non-biomedical 'others'. We argue that this overdrawn dichotomy obscures the important part played by 'informal' biomedical practice, an issue with salience well beyond India. Based on a qualitative study in rural Andhra Pradesh, South India, we focus on a figure little discussed in the academic literature - the Registered Medical Practitioner (RMP) - who occupies a niche in the medical market-place as an informal exponent of biomedical treatment...
December 2, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27905860/a-scoping-review-on-models-of-integrative-medicine-what-is-known-from-the-existing-literature
#5
Eun Jin Lim, Janette L Vardy, Byeong Sang Oh, Haryana M Dhillon
OBJECTIVES: Integrative medicine (IM) has been recognized and introduced into Western healthcare systems over the past two decades. Limited information on IM models is available to guide development of an optimal healthcare service. A scoping review was carried out to evaluate IM models in the extant literature, including the distinctive features of each model, to gain an understanding of the core requirements needed to develop models of IM that best meet the needs of patients. DESIGN: Directed content analysis was used to classify the IM models into systems based on coding schema developed from theoretical models and to identify the key concepts of each system...
December 1, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27905186/severe-asthma-current-management-targeted-therapies-and-future-directions-a-roundtable-report
#6
REVIEW
Vanessa M McDonald, Steven Maltby, Helen K Reddel, Gregory G King, Peter A B Wark, Lorraine Smith, John W Upham, Alan L James, Guy B Marks, Peter G Gibson
Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway inflammation, airway obstruction and airway hyper-responsiveness. Asthma is common and directly affects 10% of Australians, 1-5% of adults in Asia and 300 million people worldwide. It is a heterogeneous disorder with many clinical, molecular, biological and pathophysiological phenotypes. Current management strategies successfully treat the majority of patients with asthma who have access to them. However, there is a subset of an estimated 5-10% of patients with asthma who have severe disease and are disproportionately impacted by symptoms, exacerbations and overall illness burden...
November 30, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27904831/orphan-drug-development-in-china-turning-challenges-into-opportunities
#7
Xiaowei Jin, Li Chen
Of over 7,000 known rare diseases, only 5% currently have an available treatment option worldwide. Moreover, the vast majority of rare disease patients in China have no access to treatment due to limited availability and the lack of appropriate infrastructure in China's healthcare system. Despite increased interest in orphan drug development, drug companies in China with active programs on drugs to treat rare diseases are still limited. Hence, there is a huge unmet need in China, with over 10 million patients suffering from rare diseases...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27904819/an-overview-of-compassionate-use-programs-in-the-european-union-member-states
#8
REVIEW
Gayathri Balasubramanian, Suman Morampudi, Pankdeep Chhabra, Arun Gowda, Behsad Zomorodi
The past decade witnessed rapid development of novel drugs and therapeutic biological agents. The marketing authorization for novel therapies is often time consuming and distressing for patients. Earlier clinical trials were the only way to access new drugs under development. However, not every patient meets the enrolment criteria, and participation is difficult for patients with life-threatening, long-lasting or seriously debilitating diseases like rare diseases. Early access programs like "Compassionate Use Program (CUP)" have generated alternative channels for such patients...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27896882/quality-of-claims-and-references-found-in-australian-pharmacy-journal-advertisements
#9
Mona Mandoh, Colin Michael Curtain
OBJECTIVES: To evaluate the quality of pharmaceutical advertisement claims and supporting references in Australian pharmacy journals that target community pharmacists. METHODS: All full-page advertisements for a medicinal product, found in two Australian pharmacy journals from the year 2012 to 2015 were included. Advertisement claims and references were evaluated by claim type (unambiguous to immeasurable) and level of evidence (strong to irrelevant) in supporting references...
November 29, 2016: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27896681/financial-impact-of-direct-acting-oral-anticoagulants-in-medicaid-budgetary-assessment-based-on-number-needed-to-treat
#10
Kathleen A Fairman, Lindsay E Davis, Courtney R Kruse, David A Sclar
BACKGROUND: Faced with rising healthcare costs, state Medicaid programs need short-term, easily calculated budgetary estimates for new drugs, accounting for medical cost offsets due to clinical advantages. OBJECTIVE: To estimate the budgetary impact of direct-acting oral anticoagulants (DOACs) compared with warfarin, an older, lower-cost vitamin K antagonist, on 12-month Medicaid expenditures for nonvalvular atrial fibrillation (NVAF) using number needed to treat (NNT)...
November 28, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27890395/the-recommodification-of-healthcare-a-case-study-of-user-charges-and-inequalities-in-access-to-healthcare-in-sweden-1980-2005
#11
Kristin Farrants, Clare Bambra, Lotta Nylen, Adetayo Kasim, Bo Burström, David Hunter
BACKGROUND: User charges in Swedish healthcare have increased during recent decades. This can be seen in terms of the recommodification of healthcare: making healthcare access more dependent on market position. This study investigates whether the increase in user charges had an impact on educational inequalities in access to healthcare in Sweden between 1980 and 2005. METHODS: Data from the Swedish Living Conditions Survey were used to calculate the odds ratios of access to healthcare for the low and higher educated in Sweden, and the results were stratified by health status (Good and Not good health) for each year 1980-2005...
November 14, 2016: Health Policy
https://www.readbyqxmd.com/read/27889288/quiet-dissent-the-attitudes-beliefs-and-behaviours-of-uk-osteopaths-who-reject-low-back-pain-guidance-a-qualitative-study
#12
Joanna Figg-Latham, Dévan Rajendran
INTRODUCTION: Clinical guidelines are derived from best research evidence and aim to: improve quality of non-specific low back pain (nsLBP) management and identify patients at risk of suffering chronic pain. However, guideline discordant attitudes and beliefs have been identified in healthcare students and practitioners, including osteopaths. DESIGN: A qualitative approach with elements of grounded theory was used to explore underlying attitudes and beliefs of practitioners/students working in a British osteopathic education institution...
October 18, 2016: Manual Therapy
https://www.readbyqxmd.com/read/27888478/examining-the-quality-of-medicines-at-kenyan-healthcare-facilities-a-validation-of-an-alternative-post-market-surveillance-model-that-uses-standardized-patients
#13
Francis Wafula, Amy Dolinger, Benjamin Daniels, Njeri Mwaura, Guadalupe Bedoya, Khama Rogo, Ana Goicoechea, Jishnu Das, Bernard Olayo
BACKGROUND: Promoting access to medicines requires concurrent efforts to strengthen quality assurance for sustained impact. Although problems of substandard and falsified medicines have been documented in low- and middle-income countries, reliable information on quality is rarely available. OBJECTIVE: The aim of this study was to validate an alternative post-market surveillance model to complement existing models. METHODS: The study used standardized patients or mystery clients (people recruited from the local community and trained to pose as real patients) to collect medicine samples after presenting a pre-specified condition...
November 25, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27878711/a-framework-for-guiding-efforts-to-reward-value-instead-of-volume
#14
Taylor J Christensen
The U.S. healthcare system is in the midst of a major shift from fee-for-service to value-based reimbursement models. To date, these new reimbursement models have been focused on quality-contingent bonuses and cost-of-care risk sharing for providers, both of which have yielded only modest success.An analysis of health policy and business strategy literature was performed to identify the mechanisms of how value is rewarded in other industries and to understand the barriers to those mechanisms operating in the healthcare industry...
June 2016: Int J Health Econ Manag
https://www.readbyqxmd.com/read/27869875/-the-added-value-of-information-summaries-supporting-clinical-decisions-at-the-point-of-care
#15
Rita Banzi, Marien González-Lorenzo, Koren Hyogene Kwag, Stefanos Bonovas, Lorenzo Moja
Evidence-based healthcare requires the integration of the best research evidence with clinical expertise and patients' values. International publishers are developing evidence-based information services and resources designed to overcome the difficulties in retrieving, assessing and updating medical information as well as to facilitate a rapid access to valid clinical knowledge. Point-of-care information summaries are defined as web-based medical compendia that are specifically designed to deliver pre-digested, rapidly accessible, comprehensive, and periodically updated information to health care providers...
November 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27864355/disability-pension-due-to-common-mental-disorders-and-healthcare-use-before-and-after-policy-changes-a-nationwide-study
#16
S Rahman, E Mittendorfer-Rutz, K Alexanderson, J Jokinen, P Tinghög
BACKGROUND: Despite common mental disorders (CMDs) being a main reason for preterm exit from the labour market, there is limited knowledge regarding healthcare use around the time of being granted disability pension (DP) due to CMD. The aim was to study specialized healthcare use before and after being granted DP due to CMD and whether these trajectories differed before and after changes in DP granting criteria in Sweden in 2008. METHODS: Included individuals lived in Sweden, aged 19-64 years with incident DP due to CMD before (wave 1, 2005-06, n = 24 298) or after (wave 2, 2009-10, n = 4056) the changes in 2008...
November 17, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27861822/automated-delineation-of-hospital-service-areas-and-hospital-referral-regions-by-modularity-optimization
#17
Yujie Hu, Fahui Wang, Imam M Xierali
OBJECTIVE: To develop an automated, data-driven, and scale-flexible method to delineate hospital service areas (HSAs) and hospital referral regions (HRRs) that are up-to-date, representative of all patients, and have the optimal localization of hospital visits. DATA SOURCES: The 2011 state inpatient database in Florida from the Healthcare Cost and Utilization Project. STUDY DESIGN: A network optimization method was used to redefine HSAs and HRRs by maximizing patient-to-hospital flows within each HSA/HRR while minimizing flows between them...
November 16, 2016: Health Services Research
https://www.readbyqxmd.com/read/27846287/a-large-scale-initiative-inviting-patients-to-share-personal-fitness-tracker-data-with-their-providers-initial-results
#18
Joshua M Pevnick, Garth Fuller, Ray Duncan, Brennan M R Spiegel
BACKGROUND: Personal fitness trackers (PFT) have substantial potential to improve healthcare. OBJECTIVE: To quantify and characterize early adopters who shared their PFT data with providers. METHODS: We used bivariate statistics and logistic regression to compare patients who shared any PFT data vs. patients who did not. RESULTS: A patient portal was used to invite 79,953 registered portal users to share their data. Of 66,105 users included in our analysis, 499 (0...
2016: PloS One
https://www.readbyqxmd.com/read/27843789/real-world-evidence-an-indian-perspective
#19
REVIEW
Amit Dang, B N Vallish
Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs. However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data. RWE uses real world data (RWD) to generate insight, foresight, and explorative findings on diseases, products, and patient populations. There are varied sources of RWD such as administrative data, large pragmatic trials, registries, electronic health records, and health surveys...
October 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27842638/tonsillectomy-rates-in-the-south-african-private-healthcare-sector
#20
P Douglas-Jones, J J Fagan
BACKGROUND: Adeno-/tonsillectomy is a commonly performed procedure with internationally standardised and recognised indications. Despite this, there exists considerable international (190 - 850/100 000 people ≤19 years of age) and regional variation in rates. This cannot be accounted for by differences in clinical need or regional morbidity. OBJECTIVES: To describe the adeno-/tonsillectomy rate in the South African (SA) private healthcare sector and regional variations thereof...
November 2, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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