keyword
https://read.qxmd.com/read/38499034/spreading-through-air-spaces-and-thinking-about-lung-metastases
#1
JOURNAL ARTICLE
Patricia M Castro, Joana Rei, Cátia Silva, José Miranda, Miguel Guerra
INTRODUCTION: Spread through air spaces (STAS) is a novel pattern of invasion in primary lung cancers, which was introduced in the 2015 World Health Organization classification. Several studies have validated STAS to be a predictor of clinical outcome in lung adenocarcinoma. However, little is known about STAS as a mode of intraparenchymal diffusion of pulmonary metastases (PMs). OBJECTIVES: The aim of this study was to investigate the incidence of STAS among PMs and the association between STAS and clinicopathological characteristics of PMs...
October 11, 2023: Port J Card Thorac Vasc Surg
https://read.qxmd.com/read/37795398/curative-treatment-for-stage-iiic2-cervical-cancer-what-to-expect
#2
JOURNAL ARTICLE
Geovanne Pedro Mauro, Vinicius de Aquino Calheiros, Matheus Sorgi Vonsowski, Talita Avelar, Heloisa de Andrade Carvalho
BACKGROUND: Since the GOG125 study, treating radically patients with positive para-aortic lymph nodes has been a valid approach. Nevertheless, literature lacks data on how to better treat these patients since they are usually excluded from trials. In this study, we aimed to report the outcomes of patients with advanced cervical cancer and positive para-aortic lymph nodes (PAN) treated in a single tertiary/academic institution and try to identify variables that may impact survival. MATERIALS AND METHODS: We retrospectively reviewed patients with positive para-aortic lymph nodes treated in our institution...
2023: Reports of Practical Oncology and Radiotherapy
https://read.qxmd.com/read/36883193/cost-effectiveness-of-adjuvant-atezolizumab-versus-best-supportive-care-in-the-treatment-of-patients-with-resectable-early-stage-non-small-cell-lung-cancer-and-overexpression-of-pd-l1
#3
JOURNAL ARTICLE
Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Javier De Castro, Amelia Insa, Alex Martínez, Elena Fernández, Ivana Sullivan, Andrés Flores, Natalia Arrabal, David Carcedo, Alba Manzaneque
AIMS: To assess the cost-effectiveness of adjuvant atezolizumab in the treatment of early-stage NSCLC patients (stage II-IIIA) with expression PD-L1 ≥ 50% without mutations in EGFR or ALK rearrangements in Spain. MATERIALS & METHODS: A 5-states Markov model (DFS, locorregional recurrence, 1L-metastatic recurrence, 2L-metastatic recurrence, and death states) was adapted to the Spanish setting. Demographic characteristics of the hypothetical cohort, transition probabilities from the DFS state, and safety parameters were obtained from IMpower010 study (GO29527)...
March 7, 2023: Journal of Medical Economics
https://read.qxmd.com/read/36809990/economic-burden-of-locoregional-and-metastatic-relapses-in-resectable-early-stage-non-small-cell-lung-cancer-in-spain
#4
JOURNAL ARTICLE
Javier De Castro, Amelia Insa, Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Alex Martínez, Elena Fernandez, Ivana Sullivan, Natalia Arrabal, David Carcedo, Alba Manzaneque
BACKGROUND: There are scarce data of the costs of non-small cell lung cancer (NSCLC) recurrence in Spain. The objective of this study is to assess the economic burden of disease recurrence, for both locoregional and/or metastatic relapses, after appropriate early-stage NSCLC treatment in Spain. MATERIALS AND METHODS: A two-round consensus panel of Spanish oncologists and hospital pharmacists was conducted to collect information on patient's flow, treatments, use of healthcare resources and sick leaves in patients with relapsed NSCLC...
February 21, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/36531012/photodynamic-therapy-in-glioblastoma-detection-of-intraoperative-inadvertent-5-ala-mediated-photodynamic-therapeutical-effect-after-gross-total-resection
#5
JOURNAL ARTICLE
Abel Ferrés, Alberto Di Somma, Alejandra Mosteiro, Thomaz Eduardo Topczewski, Pedro Roldán, Leire Pedrosa, Diouldé Diao, Estela Pineda, Àngels Sierra, Joaquim Enseñat, José Juan González-Sánchez
INTRODUCTION: Glioblastoma (GBM) remains the most frequent and lethal primary brain tumor in adults, despite advancements in surgical resection techniques and adjuvant chemo- and radiotherapy. The most frequent recurrence pattern (75-90%) occurs in the form of continuous growth from the border of the surgical cavity, thus emphasizing the need for locoregional tumor control. Fluorescence-guided surgical resection using 5-ALA has been widely implemented in surgical protocols for such tumors...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36344409/perioperative-analgesia-by-erector-spinae-plane-block-in-left-ventricular-assist-implant
#6
O Alonso Tuñón, M Balsera Valle, J Acosta Martínez, P García Aparicio, Á Vilches Arenas
In recent years, left ventricular assist devices have become an important element in the management of left ventricular failure refractory to pharmacological treatment. Their implantation (performed by left thoracotomy or sternotomy) generates significant perioperative pain, which can be managed with locoregional anaesthesia techniques. However, opinions vary on their use in cardiac surgery due to interference with the anticoagulant therapy required in these patients. The erector spinae plane block is an alternative to classic locoregional techniques...
November 4, 2022: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/36064171/locoregional-relapse-after-sparing-mastectomies-and-immediate-reconstruction-in-women-with-breast-cancer
#7
JOURNAL ARTICLE
Benigno Acea-Nebril, Alejandra García-Novoa, Mónica Torres Díaz, Alberto Bouzón Alejandro, Carlota Díaz Carballada, Carmen Conde, Inmaculada Díaz, Carme Martínez, Lourdes Calvo, Silvia Antolin Novoa, Paz Santiago, Joaquín Mosquera Oses
INTRODUCTION: In recent years, cultural changes in today's society and improved risk assessment have increased the indication for mastectomies in women with breast cancer. Various studies have confirmed the oncological safety of sparing mastectomies and immediate reconstruction. The objective of this study is to analyze the incidence of locoregional relapses of this procedure and its impact on reconstruction and overall survival. PATIENTS AND METHODS: Prospective study of patients with breast carcinoma who underwent a sparing mastectomy and immediate reconstruction...
September 2, 2022: Cirugia española
https://read.qxmd.com/read/34181846/carcinoma-escamoso-de-lengua-y-met%C3%A3-stasis-renales-bilaterales
#8
JOURNAL ARTICLE
Rocio Bruballa, Carla Abuawad, Luis Boccalatte, Juan Larrañaga
El carcinoma escamoso de lengua es la lesión maligna más frecuente de la cavidad oral. El hallazgo de metástasis en este tipo de neoplasias se considera el principal factor de mal pronóstico con efecto marcado en la sobrevida global del paciente. La progresión habitual suele ser locorregional, en el lecho quirúrgico o a nivel ganglionar, siendo poco frecuente el hallazgo de afectación sistémica.  Se presenta el caso de un paciente masculino de 40 años de edad con diagnóstico de cáncer de lengua y metástasis renales bilaterales, a los 11 meses del diagnóstico inicial...
June 28, 2021: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/33787027/angiofibroma-nasal-juvenil-con-importante-afectaci%C3%A3-n-locorregional
#9
JOURNAL ARTICLE
Juan Ramon Y Cajal Calvo, Pablo Vela Gajón, Carlota Bello Franco, Maria Jose Gimeno Peribañez, Gloria Tejero Garcés Galve
El angiofibroma nasal juvenil es un tumor de carácter benigno, caracterizado por la vascularización abundante y tendencia a la hemorragia. A pesar de su histología benigna, puede presentar un crecimiento localmente expansivo que suele presentar una remodelación ósea y efecto masa de estructuras adyacentes. Se presenta el caso de un paciente de 15 años de edad, que acude al servicio de urgencias de nuestro centro por epistaxis de repetición. Tras la exploración física se deciden realizar pruebas de imagen (TC y RM) que ponen de manifiesto la presencia de una gran masa hipervascular en la fosa nasal derecha y seno maxilar...
March 12, 2021: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/33468362/resection-of-the-aortic-bifurcation-in-the-treatment-of-locally-recurrent-colorectal-cancer
#10
Giulia Vitiello, Begoña Soto Carricas, M Carmen Martínez Sánchez, Eduardo Targarona Soler
No abstract text is available yet for this article.
January 16, 2021: Cirugia española
https://read.qxmd.com/read/33455694/-primary-pulmonary-myxoid-sarcoma-associated-with-translocation-ewsr1-creb1-and-locorregional-micrometastases
#11
JOURNAL ARTICLE
Alejandro Salazar Nicolás, María Isabel Oviedo Ramírez, Clara Salas Antón
Primary myxoid pulmonary sarcoma is a rare entity with an endobronchial growth. Although it should be included in the differential diagnosis of other sarcomas, its prognosis is usually favorable. We present the case of a 51-year-old patient with a mesenchymal tumor in the right lung, diagnosed as a primary pulmonary myxoid sarcoma, positive for EMA, vimentine and with a Ki-67 less than 5%; FISH revealed a EWSR1-CREB1 translocation.
January 2021: Revista Española de Patología
https://read.qxmd.com/read/31804269/compliance-with-preoperative-elements-of-the-american-society-of-colon-and-rectal-surgeons-rectal-cancer-surgery-checklist-improves-pathologic-and-postoperative-outcomes
#12
MULTICENTER STUDY
Richard Garfinkle, Carol-Ann Vasilevsky, Gabriela Ghitulescu, Nancy Morin, Julio Faria, Marylise Boutros
BACKGROUND: In 2016, the American Society of Colon and Rectal Surgeons published a rectal cancer surgery checklist composed of the essential elements of preoperative, intraoperative, and postoperative care for patients undergoing rectal cancer surgery. OBJECTIVE: The purpose of this study was to assess whether compliance with preoperative checklist elements was associated with improved pathologic and 30-day postoperative outcomes after rectal cancer surgery. DESIGN: This was a retrospective cohort study...
January 2020: Diseases of the Colon and Rectum
https://read.qxmd.com/read/31494807/pain-during-and-after-hernioplasty-in-raquidian-or-locorregional-anesthesia-by-locking-peripheral-nerves
#13
JOURNAL ARTICLE
P M F de Souza, L C Ferreira, L F S Marinari, J C M Brandão, P S Carneiro, D P C Garcia, A Petroianu, L R Alberti
PURPOSE: To analyze pain scores after surgery in a group of patients submitted to inguinal hernia repair under peripheral nerve block with local or spinal anesthesia. METHODS: Fifty patients were divided into two groups (both with 25 patients each). In the first group the patients were submitted to herniorrhaphy under peripheral block and local anesthesia (LG) and in the other group the patients were submitted to the same procedure under spinal anesthesia (RG). The pain was assessed using the international visual analog pain scale at four different moments...
September 7, 2019: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/30850122/cutaneous-metastases-from-breast-cancer-an-8-year-review-of-cases-at-a-tertiary-care-hospital
#14
JOURNAL ARTICLE
D P Bastard, M L Bollea-Garlatti, A Belatti, M C Puga, M N Hernández, L D Mazzuoccolo
BACKGROUND AND OBJECTIVES: Breast cancer is the most common cause of cutaneous metastases. In our review of the literature, we found no studies that have investigated the prevalence of cutaneous metastases from breast cancer in Latin America or compared survival in relation to the site of cutaneous involvement or the presence of visceral metastases. The aims of this study were to characterize the prevalence and clinical features of cutaneous metastases from breast cancer and analyze survival in relation to site of involvement and the concomitant presence of visceral metastases...
April 2019: Actas dermo-sifiliográficas
https://read.qxmd.com/read/29759308/the-value-of-adjuvant-radiotherapy-in-cutaneous-squamous-cell-carcinoma-a-review
#15
REVIEW
J Cañueto, A Jaka, A Toll
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in humans and its incidence is rising. Although surgery is the treatment of choice for cSCC, postoperative adjuvant radiotherapy has an important role in local and locorregional disease control. In this review, we analyze the value of postoperative radiotherapy in the management of high-risk cSCC (in particular, cases with perineural invasion), cSCC with positive surgical margins, and locally advanced cSCC (with parotid gland and/or lymph node metastasis)...
July 2018: Actas dermo-sifiliográficas
https://read.qxmd.com/read/28801012/use-of-lymph-node-ultrasound-prior-to-sentinel-lymph-node-biopsy-in-384-patients-with-melanoma-a-cost-effectiveness-analysis
#16
JOURNAL ARTICLE
D Olmedo, M Brotons-Seguí, C Del Toro, M González, C Requena, V Traves, A Pla, I Bolumar, D Moreno-Ramírez, E Nagore
BACKGROUND AND OBJECTIVES: Locoregional lymph node ultrasound is not typically included in guidelines as part of the staging process prior to sentinel lymph node biopsy (SLNB). The objective of the present study was to make a clinical and economic analysis of lymph node ultrasound prior to SLNB. MATERIALS AND METHODS: We performed a retrospective study of 384 patients with clinical stage I-II primary melanoma who underwent locorregional lymph node ultrasound (with or without ultrasound-guided biopsy) prior to SLNB between 2004 and 2015...
December 2017: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/27275591/impact-of-neoadjuvant-therapy-in-downstaging-of-lower-rectal-adenocarcinoma-and-the-role-of-pelvic-magnetic-resonance-in-staging
#17
JOURNAL ARTICLE
Karina Dagre Magri, Fang Chia Bin, Fernanda Bellotti Formiga, Thiago da Silveira Manzione, Caroline Merci Caliari de Neves Gomes, Paulo de Azeredo Passos Candelári, Jorge Alberto Ortiz, Wilmar Artur Klug, José Mandia, Peretz Capelhuchnik
OBJECTIVE: to evaluate the effect of neoadjuvant therapy on the stage (TNM) of patients with rectal adenocarcinoma and validate the use of MRI as a method of determining locoregional stage. METHODS: we conducted a retrospective study of 157 patients with lower rectum adenocarcinoma, whom we divided into two groups: Group 1, 81 patients (52%) who had undergone surgical treatment initially, with the purpose to analyze the accuracy of locoregional staging by pelvic magnetic resonance imaging throug the comparison of radiological findings with pathological ones; Group 2, 76 patients (48%), who had been submitted to neoadjuvant therapy (chemotherapy and radiation) prior to definitive surgical treatment, so as to evaluate its effects on the stage by comparing clinical and radiological findings with pathology...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
https://read.qxmd.com/read/27275590/extended-pelvic-resections-for-the-treatment-of-locally-advanced-and-recurrent-anal-canal-and-colorectal-cancer-technical-aspects-and-morbimortality-predictors-aftet-24-consecutive-cases
#18
JOURNAL ARTICLE
José Wilson Benevides de Mesquita, Davy Bruno Machado, Dárcio Jânio Macedo, Diego Fonseca Cordeiro, Eurivaldo Valente de Brito, Marcelo Leite Vieira Costa
OBJECTIVE: to evaluate the profile of morbidity and mortality and its predictors related to extensive pelvic resections, including pelvic exenteration, to optimize the selection of patients and achieve better surgical results. METHODS: we performed 24 major resections for anorectal pelvic malignancy from 2008 to 2015 in the Instituto do Câncer do Ceará. The factors analyzed included age, weight loss, resected organs, total versus posterior exenteration, angiolymphatic and perineural invasion, lymph node metastasis and overall and disease-free survival...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
https://read.qxmd.com/read/25351827/retrospective-cohort-study-of-prognostic-factors-in-patients-with-oral-cavity-and-oropharyngeal-squamous-cell-carcinoma
#19
JOURNAL ARTICLE
José F Carrillo, Liliana C Carrillo, Ana Cano, Margarita C Ramirez-Ortega, Jorge G Chanona, Alejandro Avilés, Roberto Herrera-Goepfert, Jaime Corona-Rivera, Francisco J Ochoa-Carrillo, Luis F Oñate-Ocaña
BACKGROUND: Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma (SCC) are debated. The purpose of this study was to investigate the association of prognostic factors with oncologic outcomes. METHODS: Patients with oral cavity and oropharyngeal SCC treated from 1997 to 2012 were included in this retrospective cohort study. Associations of prognostic factors with locoregional recurrence (LRR) or overall survival (OS) were analyzed using the logistic regression and the Cox models...
April 2016: Head & Neck
https://read.qxmd.com/read/25010313/laparoscopic-resection-of-tumor-recurrence-after-radical-nephrectomy-for-localized-renal-cell-carcinoma
#20
JOURNAL ARTICLE
Lessandro Curcio, Antonio Claudio Cunha, Juan Renteria, Daniel Presto
INTRODUCTION: Local recurrence of Renal Cell Carcinoma (RCC) after radical nephrectomy is a rare event. Some known risk factors are: clinical/pathological stage, locorregional disease and lyimph node positivity. Since up to 30-40% of patients can achieve a disease-free status, we show a case (video) in which we performed a laparoscopic excision of a local RCC, taking advantage of all the well-known benefits of laparoscopy. CASE REPORT: A 56 years old female with a history of open radical nephrectomy two years before was diagnosed with a mass at the time of surveillance CT imaging during follow-up...
May 2014: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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