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D Olmedo, M Brotons-Seguí, C Del Toro, M González, C Requena, V Traves, A Pla, I Bolumar, D Moreno-Ramírez, E Nagore
BACKGROUND AND OBJECTIVES: Locoregional lymph node ultrasound is not typically included in guidelines as part of the staging process prior to sentinel lymph node biopsy (SLNB). The objective of the present study was to make a clinical and economic analysis of lymph node ultrasound prior to SLNB. MATERIALS AND METHODS: We performed a retrospective study of 384 patients with clinical stage I-II primary melanoma who underwent locorregional lymph node ultrasound (with or without ultrasound-guided biopsy) prior to SLNB between 2004 and 2015...
December 2017: Actas Dermo-sifiliográficas
Karina Dagre Magri, Fang Chia Bin, Fernanda Bellotti Formiga, Thiago da Silveira Manzione, Caroline Merci Caliari de Neves Gomes, Paulo de Azeredo Passos Candelári, Jorge Alberto Ortiz, Wilmar Artur Klug, José Mandia, Peretz Capelhuchnik
OBJECTIVE: to evaluate the effect of neoadjuvant therapy on the stage (TNM) of patients with rectal adenocarcinoma and validate the use of MRI as a method of determining locoregional stage. METHODS: we conducted a retrospective study of 157 patients with lower rectum adenocarcinoma, whom we divided into two groups: Group 1, 81 patients (52%) who had undergone surgical treatment initially, with the purpose to analyze the accuracy of locoregional staging by pelvic magnetic resonance imaging throug the comparison of radiological findings with pathological ones; Group 2, 76 patients (48%), who had been submitted to neoadjuvant therapy (chemotherapy and radiation) prior to definitive surgical treatment, so as to evaluate its effects on the stage by comparing clinical and radiological findings with pathology...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
José Wilson Benevides de Mesquita, Davy Bruno Machado, Dárcio Jânio Macedo, Diego Fonseca Cordeiro, Eurivaldo Valente de Brito, Marcelo Leite Vieira Costa
OBJECTIVE: to evaluate the profile of morbidity and mortality and its predictors related to extensive pelvic resections, including pelvic exenteration, to optimize the selection of patients and achieve better surgical results. METHODS: we performed 24 major resections for anorectal pelvic malignancy from 2008 to 2015 in the Instituto do Câncer do Ceará. The factors analyzed included age, weight loss, resected organs, total versus posterior exenteration, angiolymphatic and perineural invasion, lymph node metastasis and overall and disease-free survival...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
José F Carrillo, Liliana C Carrillo, Ana Cano, Margarita C Ramirez-Ortega, Jorge G Chanona, Alejandro Avilés, Roberto Herrera-Goepfert, Jaime Corona-Rivera, Francisco J Ochoa-Carrillo, Luis F Oñate-Ocaña
BACKGROUND: Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma (SCC) are debated. The purpose of this study was to investigate the association of prognostic factors with oncologic outcomes. METHODS: Patients with oral cavity and oropharyngeal SCC treated from 1997 to 2012 were included in this retrospective cohort study. Associations of prognostic factors with locoregional recurrence (LRR) or overall survival (OS) were analyzed using the logistic regression and the Cox models...
April 2016: Head & Neck
Lessandro Curcio, Antonio Claudio Cunha, Juan Renteria, Daniel Presto
INTRODUCTION: Local recurrence of Renal Cell Carcinoma (RCC) after radical nephrectomy is a rare event. Some known risk factors are: clinical/pathological stage, locorregional disease and lyimph node positivity. Since up to 30-40% of patients can achieve a disease-free status, we show a case (video) in which we performed a laparoscopic excision of a local RCC, taking advantage of all the well-known benefits of laparoscopy. CASE REPORT: A 56 years old female with a history of open radical nephrectomy two years before was diagnosed with a mass at the time of surveillance CT imaging during follow-up...
May 2014: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Thales Paulo Batista, Artur Lício Rocha Bezerra, Mário Rino Martins, Vandré Cabral Gomes Carneiro
OBJECTIVE: To explore how important is the number of pelvic lymph nodes dissected for the nodal staging in FIGO IA2-IB2 cervical cancer, submitted to radical surgical treatment. METHODS: A cross-sectional study was carried out on patients who underwent Piver class II radical hysterectomy and pelvic lymphadenectomy, in two centers in the state of Pernambuco, from January, 2001 to December, 2008. The analysis of the area under the ROC curve was adopted as a summary-measure of discriminatory power of the number of nodes dissected in predicting the pelvic nodal status...
December 2013: Einstein
M García García-Esquinas, J A García-Sáenz, J Arrazola García, M Enrique Fuentes Ferrer, V Furió, C Rodriguez Rey, J M Román, J L Carreras Delgado
AIM: Classical prognostic and predictive factors serve to predict outcome and response to neoadjuvant treatment in stage II and III breast cancer. The purpose is to determine the relation between the SUVmax of the locoregional disease with these classical prognostic factors. METHODS: A prospective study including 43 stage II and III breast cancer patients was performed. In all the patients, two 18F-FDG PET-CT studies were performed before and after neoadjuvant chemotherapy...
March 2014: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Rafael Uribarrena-Amezaga, J Ortego, J Fuentes, N Raventós, P Parra, R Uribarrena-Echevarría
BACKGROUND: 30% of patients with colorectal cancer (CRC) in Dukes stages A and B (T1-T4, N0, M0) present tumor recurrence and die after 5 years follow up. This unexpectedly poor evolution might be attributable to the presence of lymph node micrometastasis undetected in routine examination with haematoxilin-eosine (H&E). OBJECTIVE: To assess the presence of undetected micrometastasis. PATIENTS AND METHODS: we conducted a retrospective study of the locoregional lymph nodes in 85 patients operated for CRC in Dukes stages A and B (T1-T4, N0, M0), using immunohistochemistry with anticytokeratin antibodies AE1/AE3...
March 2010: Revista Española de Enfermedades Digestivas
Alejandra Martínez, Gwénael Ferron, Eliane Mery, Laurance Gladieff, Jean Pierre Delord, Denis Querleu
Pseudomyxoma peritonei (PMP) arising from urachal tumors is extremely rare. To our knowledge, natural history, tumor biological behaviour, morbidity, treatment, and prognosis of PMP arising from the urachus are determined by the associated PMP. Management of urachal tumors with associated PMP should be based on aggressive locorregional therapy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, similar to PMP arising from other origins.
March 2012: Surgical Oncology
Laura Visa, Miguel Caballero, Juan J Grau
Formerly, salivary gland cancer was considered to be chemoresistant. Chemotherapy is indicated when distant metastases or inoperable locorregional disease are observed, although the chemotherapy schedule is not well defined. Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials. Most of these studies analyze therapies with a combination of agents at full dose, although there is no clear evidence that such treatment improves survival. The administration of cytotoxic agents with low doses at frequent, regular intervals with no drug-free interruptions is known as metronomic chemotherapy...
November 2010: Acta Otorrinolaringológica Española
R Luque Mialdea, R Martin-Crespo Izquierdo, L Díaz Gómez, L Moreno, C Carrero, J Cebrian
OBJECTIVES: Description of the retroperitoneoscopic approach in the conventional pyeloplasty for ureteropelvic junction obstruction in children. MATERIAL AND METHODS: From 1998 pyeloplasty assisted by retroperitoneoscopic approach (PARA) was performed in 30 patients. TECHNIQUE: Position in latero-dorsal decubitus and incision of 1 cm in angle costolumbar. We made retroperitoneoscopic space by ball dissection technique and 11 mm Hg pressure...
April 2007: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
V Pino Rivero, C G Pantoja Hernández, A González Palomino, G Pardo Romero, G Trinidad Ramos, A Blasco Huelva
We report the clinical case of an adenoid cystic carcinoma on the base of the tongue, a rare malignant tumor of slow-growing but aggressive with a propepnsity for perineural invasion. Treatment modalities more common include surgery and radiotherapy but locorregional recurrences are frequent and relatively early in the first years. A review of the literature of this pathology is performed.
2006: Anales Otorrinolaringológicos Ibero-americanos
A Sánchez-Pernaute, E Pérez Aguirre, F Hernando Trancho, L Díez Valladares, S Ochagavía Cámara, J Calatayud Gastardi, A Torres García, J L Balibrea Cantero
AIM: To analyze the pattern of recurrence of esophageal carcinoma after a curative-intention surgical resection. PATIENTS: Ninety-two patients with non-metastatic esophageal carcinoma were included. Ninety percent of patients were male, and the mean age of this series was 61 years. The most frequent histologic subtype was squamous cell carcinoma. Fifty percent of tumors were at or above the tracheal bifurcation. All patients were submitted for transthoracic subtotal esophagectomy plus two-field radical lymphadenectomy, leaving no apparent residual disease...
March 2003: Revista Española de Enfermedades Digestivas
G Descargues, P Pitette, A Gravier, H Roman, J P Lemoine, L Marpeau
OBJECTIVE: The purpose of this work was to search for the reasons why the diagnosis of post-partum hemorrhage may be missed. PATIENTS AND METHODS: We reviewed retrospectively the files 5,517 vaginal delivery patients cared for in our Gynecology and Obstetrics Unit at the Rouen University Hospital between January 1, 1997 and September 30, 1999. Among these patients, 90 (1.63%) developed anemia during the post-partum period with a 10-point fall in the hematocrit from the pre-delivery level, which corresponds to a 1 liter loss of blood, but for whom no diagnosis of hemorrhage was made...
October 2001: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
A Martínez-Tellería, M E Cano Serrano, M J Martínez-Tellería, J Castejón Casado
A randomized, double blind study was carried out in 76 paediatric surgical patients scheduled for herniography or circumcision. Patients were randomly assigned to receive ilioinguinal and iliohipogastric nerve block (group A), penile block (group B), caudal block (group C) or metamizol intravenously (group D). Postoperative pain was evaluated by Objective pain scale at the end of surgical process and at 15, 30, 60 minutes and 6 hours after surgery. Pain free time was also recorded. There was no difference between groups regarding demographic data...
January 1997: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
E López Alcina, M Rodrigo Aliaga, M Martínez Sarmiento, J J Monserrat Monfort, S Rivas Rodero, F Jiménez Cruz
Verrucous carcinoma includes approximately 5% of all neoplasias of the penis and is a tumoral variety of benign behaviour and differentiated histology. Our 10-case experience of penial verrucous carcinoma is reported here. In nearly all cases, partial penectomy was the definitive approach. No dissemination, locorregional or distant, was found in any of the report cases. Since prognosis of these tumours is good, we see no justification in performing lymphadenectomy, although it is advisable to adopt and expectant attitude when faced to inguinal adenopathies...
June 1996: Actas Urologicas Españolas
F García-Pedrajas, J L Arroyo
Midazolam (MDZ) (8-chloro-6(2-fluoropheny 1)-1-methyl-4H-imidazol-[1,5a] [1,4]benzodiazepine) is an "annelated" benzodiazepine (BZDs) synthetized in 1976, characterized differently with the "classical" BZDs by a five-membered heterocycle fused on position 1,2 of the diazepine nucleus. This fused imidazol ring modifies the properties inherent in the "classical" BZDs in at the least three aspects: solubility, metabolisation and the stability in aqueous solution. MDZ, having similar properties with the "classical" benzodiazepines, has better local tolerance, faster onset of action, greater plasmatic clearance, shorter half-life elimination (1...
October 1989: Revista de Medicina de la Universidad de Navarra
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