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Antiinflammatory cytokines

Rocío López-Posadas, Cristina Mascaraque, Raquel González, María D Suárez, Antonio Zarzuelo, Olga Martínez-Augustin, Fermín Sánchez de Medina
BACKGROUND: Statins have antiinflammatory effects at the cardiovascular level because of inhibition of prenylation, which also probably underlies their therapeutic effects in preclinical models of inflammatory bowel disease. Another inhibitor of prenylation, namely alendronate, reduces colitis in rodents. In this study, we aim to explore the therapeutic potential of second-generation, nitrogen-containing bisphosphonates in 3 preclinical models of colitis. METHODS: The trinitrobenzenesulfonic acid and dextran sulfate sodium models of rat colitis and the adoptive lymphocyte transfer model of colitis in mice were used...
November 2016: Inflammatory Bowel Diseases
A A Grigoryuk, E P Turmova
The effect of hyperlipidemia on the systemic production of cytokines was evaluated in the plasma of rats after anterior abdominal wall reconstruction with polypropylene (Esfil) and polytetrafluorethylene (Ecoflon) endoprostheses. The reference group was formed from animals without hyperlipidemia, in which anterior abdominal wall plasty was carried out with the use of the same endoprostheses. Intact rats without hyperlipidemia and intervention served as the control. Hypercytokinemia was detected on days 1-10 after reconstructive surgery on the anterior abdominal wall...
September 2016: Bulletin of Experimental Biology and Medicine
Dong-Gyu Kim, Min Jung Kang, Seong Su Hong, Yun-Hyeok Choi, Jung Hye Shin
The antiinflammatory effects of functionally active compounds isolated from aged black garlic (AGE-1 and AGE-2) were investigated using a lipopolysaccharide-induced inflammatory response model. To examine the potential antiinflammatory properties of AGE-1 and AGE-2, cell viability as well as nitric oxide, prostaglandin E2, and pro-inflammatory cytokine [interleukin-6 (IL-6), TNF-α, and IL-1β] levels were measured. The mRNA and protein expression levels of inducible nitric oxide synthase and cyclooxygenase-2 were detected by reverse transcription polymerase chain reaction and western blotting...
September 30, 2016: Phytotherapy Research: PTR
Mohammad Ashafaq, Heena Tabassum, Suhel Parvez
Oxidative stress and inflammatory responses play a critical contributing factor in cerebral ischemia and reperfusion, which lead to lipid peroxidation and neuronal dysfunction that may represent a target for therapeutic intervention. The present study was aimed to elucidate the neuroprotective effect of tannic acid (TA), a natural polyphenol with potential antioxidant and antiinflammatory properties on middle cerebral artery occlusion (MCAO) model in rats. To test this hypothesis, male Wistar rats were pretreated with TA (50 mg/kg b...
September 27, 2016: Molecular Neurobiology
Deping Kong, Yujun Shen, Guizhu Liu, Shengkai Zuo, Yong Ji, Ankang Lu, Masataka Nakamura, Michael Lazarus, Constantine A Stratakis, Richard M Breyer, Ying Yu
The kinetic participation of macrophages is critical for inflammatory resolution and recovery from myocardial infarction (MI), particularly with respect to the transition from the M1 to the M2 phenotype; however, the underlying mechanisms are poorly understood. In this study, we found that the deletion of prostaglandin (PG) D2 receptor subtype 1 (DP1) in macrophages retarded M2 polarization, antiinflammatory cytokine production, and resolution in different inflammatory models, including the MI model. DP1 deletion up-regulated proinflammatory genes expression via JAK2/STAT1 signaling in macrophages, whereas its activation facilitated binding of the separated PKA regulatory IIα subunit (PRKAR2A) to the transmembrane domain of IFN-γ receptor, suppressed JAK2-STAT1 axis-mediated M1 polarization, and promoted resolution...
September 19, 2016: Journal of Experimental Medicine
David Millrine, Mami Tei, Yohannes Gemechu, Tadamitsu Kishimoto
Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon forms a complex with Rabex-5, a regulator of immune homeostasis. Treatment with lenalidomide prevented the association of Cereblon with Rabex-5. Conversely, mutation of the IMiD binding site increased Cereblon-Rabex-5 coimmunoprecipitation. The thalidomide binding region of Cereblon therefore regulates the formation of this complex...
September 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
Sigrun R Hofmann, Anja Schnabel, Angela Rösen-Wolff, Henner Morbach, Hermann J Girschick, Christian M Hedrich
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder, covering a clinical spectrum with asymptomatic inflammation of single bones at the one end, and chronic recurrent multifocal osteomyelitis (CRMO) at the other end. The exact molecular pathophysiology of CNO remains largely unknown. Provided familial clusters and the association with inflammatory disorders of the skin and intestine suggest a genetic predisposition. Recently, profound dysregulation of cytokine responses was demonstrated in CRMO...
September 1, 2016: Journal of Rheumatology
Marina Suênia de Araújo Vilar, Graziene Lopes de Souza, Daniela de Araújo Vilar, Jacqueline Alves Leite, Fernanda Nervo Raffin, José Maria Barbosa-Filho, Fernando Henrique Andrade Nogueira, Sandra Rodrigues-Mascarenhas, Túlio Flávio Accioly de Lima Moura
The bark of A. occidentale L. is rich in tannins. Studies have described various biological activities of the plant, including antimicrobial, antioxidant, antiulcerogenic and antiinflammatory actions. The objective of this study was to assess the activity of the ethyl acetate phase (EtOAc) of A. occidentale on acute inflammation and to identify and quantify its phenolic compounds by HPLC. The method was validated and shown to be linear, precise and accurate for catechin, epicatechin, epigallocatechin and gallic acid...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Min Ho Han, Won Sup Lee, Arulkumar Nagappan, Su Hyun Hong, Ji Hyun Jung, Cheol Park, Hye Jung Kim, Gi-Young Kim, GonSup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi
Decoctions of the dried flowers of Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against various inflammatory diseases, and it is reported neuroprotective effects. The cytokines release from microglia is closely linked to various chronic neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. It is still unknown whether the neuroprotective effects are associated with the antiinflammatory effects. Here, we determined whether polyphenols extracted from lyophilized Lonicera japonica Thunb...
August 18, 2016: Phytotherapy Research: PTR
Sareeya Reungpatthanaphong, Chaiyavat Chaiyasut, Sasithorn Sirilun, Prasit Suwannalert
Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world, with chronic inflammation and diet as major causes in its development. Chemopreventive effects of natural dietary products have been the focus of studies for prevention over the past decade. This study was conducted to determine the effects of unpolished Thai rice during precancerous stage through the involvement of ?catenin, cyclooxygenase2 (COX2) expression and inflammatory cytokines focusing on azoxymethane (AOM)induced aberrant crypt foci (ACF)related to CRC...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Shinki Murakami, Shingo Eikawa, Savas Kaya, Mitsuko Imao, Toshiki Aji
Various beneficial effects have been described for fermented papaya preparation (FPP: SAIDOPS501) based on its antioxidative and antiinflammatory functions. The present study was designed to determine the effects of FPP on carcinogenesis in vivo, and immunomodulatory function in vitro. Mice were injected with RL male 1 cells subcutaneously or 3methylcholantherene (MCA) intravenously to induce cancer and orally or intraperitoneally treated with FPP solution. Human peripheral blood mononuclear cells (PBMC) were obtained from healthy volunteers and patients with atopic dermatitis, treated with FPP, and subjected to measurement of cytokine production and changes in Foxp3expressing regulatory T cell (Treg) stimulated with phytohemagglutinin (PHA)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
İlknur Bingül, A Fatih Aydın, Canan Başaran-Küçükgergin, Işın Doğan-Ekici, Jale Çoban, Semra Doğru-Abbasoğlu, Müjdat Uysal
Steatosis, the first lesion in non-alcoholic fatty liver disease (NAFLD), may progress to fibrosis, cirrhosis, and hepatocellular carcinoma. Steatosis predisposes the liver to oxidative stress, inflammation, and cytokines. Betaine (BET) has antioxidant, antiinflammatory and hepatoprotective effects. However, the effects of BET on liver fibrosis development are unknown. Rats were treated with high-fat diet (60% of total calories from fat) for 14weeks. Carbon tetrachloride (0.2mL/kg; two times per week; i.p.) was administered to rats in the last 6weeks with/without commercial food containing BET (2%; w/w)...
October 2016: International Immunopharmacology
Satona Tanaka, Toyofumi F Chen-Yoshikawa, Moto Kajiwara, Toshi Menju, Keiji Ohata, Mamoru Takahashi, Takeshi Kondo, Kyoko Hijiya, Hideki Motoyama, Akihiro Aoyama, Satohiro Masuda, Hiroshi Date
BACKGROUND: Ischemia/reperfusion injury (IRI) remains a significant complication after lung transplantation. Endothelial damage and inflammation contribute to its development. Imatinib has been reported to regulate vascular permeability by maintaining endothelial junctions and showing antiinflammatory effects through inhibition of the Abl kinases. We hypothesized that imatinib could have a protective effect against IRI. METHODS: Male Lewis rats were heparinized and underwent left thoracotomy, and the left hilum was clamped for 90 minutes followed by reperfusion for 120 minutes...
July 23, 2016: Annals of Thoracic Surgery
Oyindamola O Abiodun, Alba Rodríguez-Nogales, Francesca Algieri, Ana Maria Gomez-Caravaca, Antonio Segura-Carretero, M Pilar Utrilla, M Elena Rodriguez-Cabezas, Julio Galvez
ETHNOPHARMOCOLOGICAL RELEVANCE: Terminalia catappa Linn (Combretaceae) is a medicinal plant with anti-inflammatory, anti-diarrhoeal and antioxidant properties, frequently found in tropical regions. Considering its characteristics, it could be useful for the treatment of inflammatory bowel disease, which is associated with inflammation, oxidative stress and an immune dysfunction. Thus this study evaluates the immunomodulatory properties and the intestinal anti-inflammatory effect of an ethanolic extract of the stem bark of T...
November 4, 2016: Journal of Ethnopharmacology
Ruiyan Li, Yingying Chen, Meijing Shi, Xinxin Xu, Yaxing Zhao, Xiaojun Wu, Yubin Zhang
BACKGROUND: Gegen Qinlian decoction (GQ), a Chinese medicinal herb decoction, has been widely used as efficient medicine for the treatment of acute colitis in clinics, but underlying molecular mechanisms have not been fully clarified. HYPOTHESIS/PURPOSE: Inflammation and oxidative stress have been reported to constitute a crucial part in the pathogenesis of ulcerative colitis (UC). Hence, this study was designed to investigate the antiinflammatory activity and antioxidative effect of GQ...
September 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
I E Malysheva, L V Topchieva, O Y Barysheva, I V Kurbatova, O A Vasykova, N N Vezikova, I M Marusenko, N N Nemova
The level of TNFα and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the RA patients with MT therapy compared to the patients without MT therapy...
May 2016: Doklady. Biochemistry and Biophysics
Tiago F Granja, David Köhler, Jessica Schad, Claudia Bernardo de Oliveira, Franziska Konrad, Michaela Hoch-Gutbrod, Ariane Streienberger, Peter Rosenberger, Andreas Straub
BACKGROUND: Liver ischemia/reperfusion (IR) injury is characterized by hepatic tissue damage and an inflammatory response. This is accompanied by the formation and vascular sequestration of platelet-neutrophil conjugates (PNCs). Signaling through Adora2b adenosine receptors can provide liver protection. Volatile anesthetics may interact with adenosine receptors. This study investigates potential antiinflammatory effects of the volatile anesthetic sevoflurane during liver IR. METHODS: Experiments were performed ex vivo with human blood and in a liver IR model with wild-type, Adora2a, and Adora2b mice...
September 2016: Anesthesiology
Kieran Murphy, Gavin Elias, Jim Steppan, Chett Boxley, Kuberan Balagurunathan, Xylophone Victor, Thomas Meaders, Mario Muto
PURPOSE: To elucidate the mechanism of action of intradiscal oxygen-ozone therapy for herniated intervertebral disc therapy. METHODS: Ozone's mechanism of action was investigated using 3 approaches: mathematical models of intervertebral disc space to explore the relationship between disc pressure and volume; ozonolysis experiments using glycosaminoglycans (GAGs) from a Chinese hamster ovary cell line that were similar in composition to GAGs found in human nucleus pulposus; and experiments in which live Yucatan miniature pigs received various concentrations of percutaneous, image-guided intradiscal oxygen-ozone treatment and were examined (after sacrifice) with histology and semiquantitative analysis of disc cytokine concentrations...
August 2016: Journal of Vascular and Interventional Radiology: JVIR
L A Berchtold, M Prause, J Størling, T Mandrup-Poulsen
The discovery 30 years ago that inflammatory cytokines cause a concentration, activity, and time-dependent bimodal response in pancreatic β-cell function and viability has been a game-changer in the fields of research directed at understanding inflammatory regulation of β-cell function and survival and the causes of β-cell failure and destruction in diabetes. Having until then been confined to the use of pathophysiologically irrelevant β-cell toxic chemicals as a model of β-cell death, researchers could now mimic endocrine and paracrine effects of the cytokine response in vitro by titrating concentrations in the low to the high picomolar-femtomolar range and vary exposure time for up to 14-16h to reproduce the acute regulatory effects of systemic inflammation on β-cell secretory responses, with a shift to inhibition at high picomolar concentrations or more than 16h of exposure to illustrate adverse effects of local, chronic islet inflammation...
2016: Advances in Clinical Chemistry
Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Zhe Zhu, Changwei Qiu, Ganzhen Deng
Mastitis is defined as the inflammation of the mammary gland. There is generally no effective treatment for mastitis in animals. Puerarin, extracted from Radix puerariae, has been proven to possess many biological activities. The present study aims to reveal the potential mechanism that is responsible for the antiinflammatory action of puerarin in Staphylococcus aureus (S. aureus)-induced mastitis in mice. Histopathological changes showed that puerarin ameliorated the inflammatory injury induced by S. aureus...
June 23, 2016: Phytotherapy Research: PTR
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