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https://www.readbyqxmd.com/read/26109764/hepatorenal-protective-effect-of-antistax-%C3%A2-against-chemically-induced-toxicity
#1
Atallah F Ahmed, Hanan M Al-Yousef, Jawaher H Al-Qahtani, Mansour S Al-Said, AbdelKader E Ashour, Mohammed Al-Sohaibani, Syed Rafatullah
BACKGROUND: Antioxidant natural products and chemoprevention are considered nowadays as an effective approach against health various disorders and diseases induced by oxidative stress or free radicals. OBJECTIVE: The aim of this study was to assess the hepato- and nephroprotective activity of a standardized red vine leaf aqueous extract AS195 (Antistax(®)). METHODS: The protective activity of AS195 (100 mg/kg) was investigated on carbon tetrachloride (CCl4)-intoxicated rats in comparison with silymarin...
May 2015: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/24368431/choline-supplementation-protects-against-liver-damage-by-normalizing-cholesterol-metabolism-in-pemt-ldlr-knockout-mice-fed-a-high-fat-diet
#2
Ala Al Rajabi, Gabriela S F Castro, Robin P da Silva, Randy C Nelson, Aducio Thiesen, Helio Vannucchi, Donna F Vine, Spencer D Proctor, Catherine J Field, Jonathan M Curtis, René L Jacobs
Dietary choline is required for proper structure and dynamics of cell membranes, lipoprotein synthesis, and methyl-group metabolism. In mammals, choline is synthesized via phosphatidylethanolamine N-methyltransferase (Pemt), which converts phosphatidylethanolamine to phosphatidylcholine. Pemt(-/-) mice have impaired VLDL secretion and developed fatty liver when fed a high-fat (HF) diet. Because of the reduction in plasma lipids, Pemt(-/-)/low-density lipoprotein receptor knockout (Ldlr(-/-)) mice are protected from atherosclerosis...
March 2014: Journal of Nutrition
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