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https://www.readbyqxmd.com/read/28938646/concordance-between-circulating-tumor-cells-and-clinical-status-during-follow-up-in-anaplastic-lymphoma-kinase-alk-non-small-cell-lung-cancer-patients
#1
Mariano Provencio, David Pérez-Callejo, María Torrente, Paloma Martin, Virginia Calvo, Lourdes Gutiérrez, Fernando Franco, Maria José Coronado, Juan Luis Cruz-Bermúdez, Asunción Martín Ruiz-Valdepeñas, Alberto Cruz-Bermúdez, Margarita Sánchez-Beato, Atocha Romero, Aránzazu García-Grande
BACKGROUND: The identification of anaplastic lymphoma kinase (ALK) rearrangements is found in approximately 5% of non-small-cell lung cancers (NSCLCs). However, the development of liquid biopsies as a diagnostic tool is less developed in these cases. This study investigates the use of CTCs during treatment, together with an extended follow-up to correlate with clinical evolution. PATIENTS AND METHODS: A total of 13 patients out of a cohort of 212 patients with lung adenocarcinoma, presented ALK rearrangements (6%) confirmed by tumor biopsy...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938167/a-method-for-measuring-manual-position-control
#2
Cory Adam Potts, Alexander A Brown, Stanislaw Solnik, David A Rosenbaum
There is no generally accepted method for measuring manual position control. We developed a method for doing so. We asked university students to hold a handle that had one rotational degree of freedom. The angular position of the handle depended on the degree of pronation-supination of the forearm. The subjects' task was to hold the handle as steadily as possible to keep a needle positioned in a pie-shaped target zone on a computer screen. If the needle remained in the zone for 0.5s, the gain of the feedback loop increased; otherwise the gain decreased or remained at the starting value of 1...
September 19, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28936915/review-of-the-evidence-best-analgesic-regimen-for-shoulder-surgery
#3
Yolanda Huang, Felicia Chiu, Christopher Aj Webb, Paul David Weyker
Multimodal pain management has been advocated in patients experiencing acute pain after surgical procedures due to tissue damage and the subsequent inflammatory response. For patients undergoing shoulder surgeries, studies have definitively shown that interscalene blocks (ISBs) via single-injection or continuous infusion can reduce the total opioid consumption and can lower pain scores after surgery. In some cases, ISBs can be used as the sole anesthetic during shoulder surgeries and spare patients of receiving general anesthesia...
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28936622/prevalence-of-psychopathology-in-bipolar-high-risk-offspring-and-siblings-a-meta-analysis
#4
REVIEW
Phoebe Lau, David J Hawes, Caroline Hunt, Andrew Frankland, Gloria Roberts, Philip B Mitchell
This meta-analysis aimed to update existing data on the comparison of prevalence rates of psychopathology primarily among offspring with at least one parent with bipolar disorder (BD) and offspring of parents without psychiatric illness. Seventeen studies were derived from a systematic search of PsychInfo, Medline, Scopus and Embase. Inclusion criteria were use of a control offspring group, standardized diagnostic procedures and reporting of clear frequency data. Risk of psychopathology was estimated by aggregating frequency data from selected studies...
September 21, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28935924/multipurpose-silicon-photonics-signal-processor-core
#5
Daniel Pérez, Ivana Gasulla, Lee Crudgington, David J Thomson, Ali Z Khokhar, Ke Li, Wei Cao, Goran Z Mashanovich, José Capmany
Integrated photonics changes the scaling laws of information and communication systems offering architectural choices that combine photonics with electronics to optimize performance, power, footprint, and cost. Application-specific photonic integrated circuits, where particular circuits/chips are designed to optimally perform particular functionalities, require a considerable number of design and fabrication iterations leading to long development times. A different approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware implemented by a two-dimensional photonic waveguide mesh realizes different functionalities through programming...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935681/sex-differences-in-the-utilization-and-outcomes-of-surgical-aortic-valve-replacement-for-severe-aortic-stenosis
#6
Zakeih Chaker, Vinay Badhwar, Fahad Alqahtani, Sami Aljohani, Chad J Zack, David R Holmes, Charanjit S Rihal, Mohamad Alkhouli
BACKGROUND: Studies assessing the differential impact of sex on outcomes of aortic valve replacement (AVR) yielded conflicting results. We sought to investigate sex-related differences in AVR utilization, patient risk profile, and in-hospital outcomes using the Nationwide Inpatient Sample. METHODS AND RESULTS: In total, 166 809 patients (63% male and 37% female) who underwent AVR between 2003 and 2014 were identified, and 48.5% had a concomitant cardiac surgery procedure...
September 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28935340/risk-factors-outcomes-and-timing-of-manipulation-under-anesthesia-after-total-knee-arthroplasty
#7
Erik T Newman, Thomas A Herschmiller, David E Attarian, Thomas P Vail, Michael P Bolognesi, Samuel S Wellman
BACKGROUND: Knee stiffness requiring manipulation under anesthesia (MUA) is an undesirable outcome following total knee arthroplasty (TKA), but risk factors for, and optimal timing of, MUA remain unclear. METHODS: Primary TKAs performed at a single center were retrospectively reviewed. Clinical variables were compared between patients who underwent MUA and those who did not; variables that differed were utilized to identify an appropriately matched control group of non-MUA patients...
August 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28935210/office-based-procedures-for-the-diagnosis-and-treatment-of-laryngeal-pathology
#8
REVIEW
David J Wellenstein, Henrieke W Schutte, Robert P Takes, Jimmie Honings, Henri A M Marres, James A Burns, Guido B van den Broek
INTRODUCTION: Since the development of distal chip endoscopes with a working channel, diagnostic and therapeutic possibilities in the outpatient clinic in the management of laryngeal pathology have increased. Which of these office-based procedures are currently available, and their clinical indications and possible advantages, remains unclear. MATERIAL AND METHODS: Review of literature on office-based procedures in laryngology and head and neck oncology. RESULTS: Flexible endoscopic biopsy (FEB), vocal cord injection, and laser surgery are well-established office-based procedures that can be performed under topical anesthesia...
September 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28934803/two-interesting-cases-of-meralgia-paraesthetica
#9
Christopher David Jones, Luke Guiot, Mark Portelli, Timothy Bullen, Paul Skaife
Meralgia paraesthetica (MP) is a condition originally described by Bernhardt in 1878 and was eventually named by Roth in 1895. It is caused by compression of the lateral femoral cutaneous nerve (LFCN) resulting in varying types of discomfort. Severity of the symptoms can range from mildly uncomfortable to painfully disabling. In this article we discuss 2 patients with a LFCN injury occurring as a result of laparoscopic ventral rectopexy (LVR). The first patient is a 46-year-old female who reported pain and dysesthesia in the left groin and the anterolateral thigh, 2 days post LCR...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28933910/ranking-low-feeling-high-how-hierarchical-position-and-experienced-power-promote-prosocial-behavior-in-response-to-procedural-justice
#10
Marius van Dijke, David De Cremer, Gerben Langendijk, Cameron Anderson
Research shows that power can lead to prosocial behavior by facilitating the behavioral expression of dispositional prosocial motivation. However, it is not clear how power may facilitate responses to contextual factors that promote prosocial motivation. Integrating fairness heuristic theory and the situated focus theory of power, we argue that in particular, organization members in lower (vs. higher) hierarchical positions who simultaneously experience a high (vs. low) sense of power respond with prosocial behavior to 1 important antecedent of prosocial motivation, that is, the enactment of procedural justice...
September 21, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28932282/management-of-post-traumatic-stiffness-of-the-shoulder-following-upper-limb-trauma-with-manipulation-under-anaesthetic
#11
Sarah T Lancaster, Thomas N Grove, David A Woods
BACKGROUND: A proportion of patients who sustain upper limb fractures develop post-traumatic stiffness (PTS), which may progress in a similar way to primary frozen shoulder (PFS). We have had success in treating PFS with manipulation under anaesthetic (MUA) and therefore treated PTS using MUA. Oxford Shoulder Scores (OSS), range of motion (ROM) data pre- and post-MUA, and the need for repeat procedure were compared. METHODS: Sixty-four patients with PTS following an upper limb fracture, unresponsive to conservative measures, were seen between 1 January 1999 and 1 November 2015...
October 2017: Shoulder & Elbow
https://www.readbyqxmd.com/read/28932276/contemporary-best-practice-in-the-evaluation-and-management-of-stuttering-priapism
#12
REVIEW
Georgios Kousournas, Asif Muneer, David Ralph, Evangelos Zacharakis
Stuttering priapism is rare and under-investigated clinical entity. Although it shares similarities with ischaemic priapism, by definition, stuttering priapism has distinct characteristics that advocate for a different management in the clinical setting. Therefore, the management of stuttering priapism aims primarily to prevent recurrence rather than the resolution of spontaneous attacks. A multimodal approach and the individualization of each case are essential because of the diversity of the condition and the plethora of proposed therapeutic strategies...
September 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28932265/removal-of-glucuronic-acid-from-xylan-is-a-strategy-to-improve-the-conversion-of-plant-biomass-to-sugars-for-bioenergy
#13
Jan J Lyczakowski, Krzysztof B Wicher, Oliver M Terrett, Nuno Faria-Blanc, Xiaolan Yu, David Brown, Kristian B R M Krogh, Paul Dupree, Marta Busse-Wicher
BACKGROUND: Plant lignocellulosic biomass can be a source of fermentable sugars for the production of second generation biofuels and biochemicals. The recalcitrance of this plant material is one of the major obstacles in its conversion into sugars. Biomass is primarily composed of secondary cell walls, which is made of cellulose, hemicelluloses and lignin. Xylan, a hemicellulose, binds to the cellulose microfibril and is hypothesised to form an interface between lignin and cellulose. Both softwood and hardwood xylan carry glucuronic acid side branches...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28930954/acute-procedural-interventions-after-pediatric-blunt-abdominal-trauma-a-prospective-multicenter-evaluation
#14
Chase A Arbra, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Christian J Streck
BACKGROUND: Pediatric intra-abdominal injuries (IAI) from blunt abdominal trauma (BAT) rarely require emergent intervention. For those children undergoing procedural intervention, our aim was to understand the timing and indications for operation and angiographic embolization. METHODS: We prospectively enrolled children younger than 16 years after BAT at 14 Level I Pediatric Trauma Centers over a 1-year period. Patients with IAI who received an intervention (IAI-I) were compared with those who did not receive an intervention using descriptive statistics and univariate analysis; p less than 0...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930712/the-ethics-of-research-in-lower-income-countries-double-standards-are-not-the-problem
#15
David S Wendler
Discussion of the ethics of clinical trials in lower income countries has been dominated by concern over double standards. Most prominently, clinical trials of interventions that are less effective than the worldwide best treatment methods typically are not permitted in higher income countries. Commentators conclude that permitting such trials in lower income countries involves an ethical double standard. Despite significant attention to this concern, and its influence over prominent guidelines for research in lower income countries, there has been little analysis of what constitutes an ethical double standard in clinical research...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28929865/false-positive-screens-and-lung-cancer-risk-in-the-national-lung-screening-trial-implications-for-shared-decision-making
#16
Paul F Pinsky, Christina R Bellinger, David P Miller
Objectives Low-dose computed tomography lung cancer screening has been shown to reduce lung cancer mortality but has a high false-positive rate. The precision medicine approach to low-dose computed tomography screening assesses subjects' benefits versus harms based on their personal lung cancer risk, where harms include false-positive screens and resultant invasive procedures. We assess the relationship between lung cancer risk and the rate of false-positive LDCT screens. Methods The National Lung Screening Trial randomized high-risk subjects to three annual screens with low-dose computed tomography or chest radiographs...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28929218/percutaneous-gastric-remnant-gastrostomy-following-roux-en-y-gastric-bypass-surgery-a-single-tertiary-center-s-13-year-experience
#17
Shehbaz Hasam Shaikh, Justin Jay Stenz, David W McVinnie, James J Morrison, Todd Getzen, Arthur M Carlin, Farhaan R Mir
PURPOSE: The purpose of the study is to evaluate the indications, techniques, and outcomes for percutaneous gastrostomy placement in the gastric remnant following Roux-en-Y gastric bypass (RYGB) in bariatric patients. MATERIALS AND METHODS: Retrospective chart review and summary statistical analysis was performed on all RYGB patients that underwent attempted percutaneous remnant gastrostomy placement at our institution between April 2003 and November 2016. RESULTS: A total of 38 patients post-RYGB who underwent gastric remnant gastrostomy placement were identified, 32 women and 6 men, in which a total of 41 procedures were attempted...
September 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28929187/morden-synthetic-material-is-a-safe-and-effective-alterative-for-medial-patellofemoral-ligament-reconstruction
#18
Paul Y F Lee, David Golding, Sam Rozewicz, Amit Chandratreya
PURPOSE: Medial patellofemoral ligament (MPFL) reconstruction is often performed using gracilis autografts, which may be associated with donor site morbidity and complications. The use of a synthetic material can circumvent a harvest operation and has previously been demonstrated to be effective in other types of reconstructive procedures and may be effective in MPFL reconstruction. This study reports the clinical result with the use of a morden ultra-high molecular weight polyethylene with a braided jacket of polyester tape (FT) in MPFL reconstruction compared to using standard autografts...
September 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28928442/genome-wide-association-and-hla-region-fine-mapping-studies-identify-susceptibility-loci-for-multiple-common-infections
#19
Chao Tian, Bethann S Hromatka, Amy K Kiefer, Nicholas Eriksson, Suzanne M Noble, Joyce Y Tung, David A Hinds
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28927667/development-and-validation-of-a-tool-to-evaluate-the-evolution-of-clinical-reasoning-in-trauma-using-virtual-patients
#20
David Fleiszer, Michael L Hoover, Nancy Posel, Tarek Razek, Simon Bergman
CONTEXT: Undergraduate medical students at a large academic trauma center are required to manage a series of online virtual trauma patients as a mandatory exercise during their surgical rotation. PURPOSE: Clinical reasoning during undergraduate medical education can be difficult to assess. The purpose of the study was to determine whether we could use components of the students' virtual patient management to measure changes in their clinical reasoning over the course of the clerkship year...
September 16, 2017: Journal of Surgical Education
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