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https://www.readbyqxmd.com/read/29169195/wide-field-piecemeal-cold-snare-polypectomy-of-large-sessile-serrated-polyps-without-a-submucosal-injection-is-safe
#1
David J Tate, Halim Awadie, Farzan F Bahin, Lobke Desomer, Ralph Lee, Steven J Heitman, Kathleen Goodrick, Michael J Bourke
Background and study aims Large series suggest endoscopic mucosal resection is safe and effective for the removal of large (≥ 10 mm) sessile serrated polyps (SSPs), but it exposes the patient to the risks of electrocautery, including delayed bleeding. We examined the feasibility and safety of piecemeal cold snare polypectomy (pCSP) for the resection of large SSPs. Methods Sequential large SSPs (10 - 35 mm) without endoscopic evidence of dysplasia referred over 12 months to a tertiary endoscopy center were considered for pCSP...
November 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/29168554/relation-between-denaturation-time-measured-by-optical-coherence-reflectometry-and-thermal-lesion-depth-during-radiofrequency-cardiac-ablation-feasibility-numerical-study
#2
Ana González-Suárez, David Herranz, Enrique Berjano, Jose L Rubio-Guivernau, Eduardo Margallo-Balbás
BACKGROUND/OBJECTIVE: Radiofrequency (RF) catheter ablation is a minimally invasive medical procedure used to thermally destroy the focus of cardiac arrhythmias. Novel optical techniques are now being integrated into RF catheters in order to detect the changes in tissue properties. Loss of birefringence due to fiber denaturation at around 70°C is related to changes in accumulated phase retardation and can be measured by polarization-sensitive optical coherence reflectometry (PS-OCR)...
November 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29167226/surgical-enlargement-of-the-aortic-root-does-not-increase-the-operative-risk-of-aortic-valve-replacement
#3
Rodolfo V Rocha, Cedric Manlhiot, Christopher M Feindel, Terrence M Yau, Brigitte Mueller, Tirone E David, Maral Ouzounian
Background -Surgical aortic root enlargement (ARE) during aortic valve replacement (AVR) allows for larger prosthesis implantation and may be an important adjunct to surgical AVR in the transcatheter valve-in-valve era. The incremental operative risk of adding ARE to AVR has not been established. We sought to evaluate the early outcomes of patients undergoing AVR with or without ARE. Methods -From January 1990 to August 2014, 7039 patients underwent AVR (AVR + ARE, n=1854; AVR, n=5185) at a single institution...
November 22, 2017: Circulation
https://www.readbyqxmd.com/read/29166455/progression-and-prognosis-of-paravalvular-regurgitation-after-transcatheter-aortic-valve-implantation
#4
Rafael Alexandre Meneguz-Moreno, Antônio de Castro-Filho, Auristela Isabel de Oliveira Ramos, Mayra Zumarraga, David Le Bihan, Rodrigo Barretto, Dimytri Alexandre de Alvim Siqueira, Alexandre Antonio Cunha Abizaid, Amanda Guerra de Moraes Rego Sousa, J Eduardo Sousa
BACKGROUND: The impact of paravalvular regurgitation (PVR) following transcatheter aortic valve implantation (TAVI) remains uncertain. OBJECTIVE: To evaluate the impact of PVR on mortality and hospital readmission one year after TAVI. METHODS: Between January 2009 and June 2015, a total of 251 patients underwent TAVI with three different prostheses at two cardiology centers. Patients were assessed according to PVR severity after the procedure...
November 13, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29165939/-importance-of-handoffs-for-patient-safety
#5
Fanny Berlincourt, Dominik Rebell, David Gachoud, Matteo Monti
Handoffs are defined as the transfer of mission specific information and care authority from one healthcare professional to another. Handoffs may create gaps that are especially vulnerable to errors and may have an impact on patient safety. Conceptualising handoffs that are safe gains in importance in medicine with the growing clinical complexity, the reduction of working hours, and a great amount of care fragmentation. Different strategies on the handoff procedure have been identified to improve patient safety...
November 22, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29164727/highly-efficient-synthesis-of-a-staphylococcus-aureus-targeting-payload-enabling-the-first-antibody-antibiotic-conjugate
#6
Xin Linghu, Nathaniel Segraves, Ifat Abramovich, Nicholas Wong, Barbara Müller, Nadja Neubauer, Serena Fantasia, Sebastian Rieth, Stephan Bachmann, Michael Jansen, C Gregory Sowell, David Askin, Stefan Koenig, Francis Gosselin
A practical synthesis of the complex payload for an anti-Staphylococcus aureus THIOMAB TM antibody-antibiotic conjugate (TAC) is described. The route takes advantage of a delicate oxidative condensation, achieved via a semi-continuous flow procedure. It allows for the generation of kilogram quantities of a key intermediate to enable a mild nucleophilic aromatic substitution to the tertiary amine free drug. The linker component is introduced as a benzylic chloride, which allows formation of the quaternary ammonium salt linker-drug...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29164705/molecular-engineering-of-mn-ii-diamine-diketonate-precursors-for-the-vapor-deposition-of-manganese-oxide-nanostructures
#7
Chiara Maccato, Lorenzo Bigiani, Giorgio Carraro, Alberto Gasparotto, Roberta Seraglia, Jiyeon Kim, Anjana Devi, Gloria Tabacchi, Ettore Fois, Giuseppe Pace, Vito Di Noto, Davide Barreca
Molecular engineering of manganese(II) diamine diketonate precursors is a key issue for their use in the vapor deposition of manganese oxide materials. Herein, two closely related β-diketonate diamine Mn(II) adducts with different fluorine contents in the diketonate ligands are examined. The target compounds were synthesized by a simple procedure and, for the first time, thoroughly characterized by a joint experimental-theoretical approach, to understand the influence of the ligand on their structures, electronic properties, thermal behavior, and reactivity...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29164255/effect-of-an-indwelling-pleural-catheter-vs-talc-pleurodesis-on-hospitalization-days-in-patients-with-malignant-pleural-effusion-the-ample-randomized-clinical-trial
#8
Rajesh Thomas, Edward T H Fysh, Nicola A Smith, Pyng Lee, Benjamin C H Kwan, Elaine Yap, Fiona C Horwood, Francesco Piccolo, David C L Lam, Luke A Garske, Ranjan Shrestha, Christopher Kosky, Catherine A Read, Kevin Murray, Y C Gary Lee
Importance: Indwelling pleural catheter and talc pleurodesis are established treatments for malignant pleural effusions among patients with poor prognosis. Objective: To determine whether indwelling pleural catheters are more effective than talc pleurodesis in reducing total hospitalization days in the remaining lifespan of patients with malignant pleural effusion. Design, Setting, and Participants: This open-label, randomized clinical trial included participants recruited from 9 centers in Australia, New Zealand, Singapore, and Hong Kong between July 2012 and October 2014; they were followed up for 12 months (study end date: October 16, 2015)...
November 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29163915/field-deployable-quantitative-rapid-identification-of-active-ebola-virus-infection-in-unprocessed-blood
#9
Kavit Shah, Emma Bentley, Adam Tyler, Kevin S R Richards, Edward Wright, Linda Easterbrook, Diane Lee, Claire Cleaver, Louise Usher, Jane E Burton, James K Pitman, Christine B Bruce, David Edge, Martin Lee, Nelson Nazareth, David A Norwood, Sterghios A Moschos
The West African Ebola virus outbreak underlined the importance of delivering mass diagnostic capability outside the clinical or primary care setting in effectively containing public health emergencies caused by infectious disease. Yet, to date, there is no solution for reliably deploying at the point of need the gold standard diagnostic method, real time quantitative reverse transcription polymerase chain reaction (RT-qPCR), in a laboratory infrastructure-free manner. In this proof of principle work, we demonstrate direct performance of RT-qPCR on fresh blood using far-red fluorophores to resolve fluorogenic signal inhibition and controlled, rapid freeze/thawing to achieve viral genome extraction in a single reaction chamber assay...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163327/the-state-of-neurocritical-care-fellowship-training-and-attitudes-toward-accreditation-and-certification-a-survey-of-neurocritical-care-fellowship-program-directors
#10
Rajat Dhar, Venkatakrishna Rajajee, Anna Finley Caulfield, Matthew B Maas, Michael L James, Avinash Bhargava Kumar, Stephen A Figueroa, David McDonagh, Agnieszka Ardelt
Neurocritical care as a recognized and distinct subspecialty of critical care has grown remarkably since its inception in the 1980s. As of 2016, there were 61 fellowship training programs accredited by the United Council for Neurologic Subspecialties (UCNS) in the United States and more than 1,000 UCNS-certified neurointensivists from diverse medical backgrounds. In late 2015, the Program Accreditation, Physician Certification, and Fellowship Training (PACT) Committee of the Neurocritical Care Society (NCS) was convened to promote and support excellence in the training and certification of neurointensivists...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163118/semi-automated-anatomical-labeling-and-inter-subject-warping-of-high-density-intracranial-recording-electrodes-in-electrocorticography
#11
Liberty S Hamilton, David L Chang, Morgan B Lee, Edward F Chang
In this article, we introduce img_pipe, our open source python package for preprocessing of imaging data for use in intracranial electrocorticography (ECoG) and intracranial stereo-EEG analyses. The process of electrode localization, labeling, and warping for use in ECoG currently varies widely across laboratories, and it is usually performed with custom, lab-specific code. This python package aims to provide a standardized interface for these procedures, as well as code to plot and display results on 3D cortical surface meshes...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29162981/the-impact-of-complications-on-patients-assessment-of-the-outcome-of-tension-free-vaginal-tape-procedure
#12
David Shaker, Alexander J Lindgren, Gwenda Chapman
Introduction: Our study aimed to assess the impact of managed complications of tension-free vaginal tape (TVT) on the patients' assessment of the results as measured by Patient Global Impression of Improvement (PGI-I). Materials and methods: This was a retrospective study, supplemented with a telephone interview, comparing patients who had complications of TVT procedures with those where no complications recorded. The primary outcome was the PGI-I score in the 2 groups...
2017: Clinical Medicine Insights. Reproductive Health
https://www.readbyqxmd.com/read/29162358/heart-transplantation-for-chagas-cardiomyopathy
#13
Ana Rita Ramalho, David Prieto, Fátima Franco, Manuel J Antunes
Chagas disease is an endemic disease in Latin America that is increasingly found in non-endemic areas all over the world due to the flow of migrants from Central and South America. We present the case of a Brazilian immigrant in Portugal who underwent orthotopic heart transplantation for end-stage Chagas cardiomyopathy. Immunosuppressive therapy included prednisone, mycophenolate mofetil and tacrolimus. Twelve months after the procedure she is asymptomatic, with good graft function, and with no evidence of complications such as graft rejection, opportunistic infections, neoplasms or reactivation of Trypanosoma cruzi infection...
November 18, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29161965/i-am-there-%C3%A2-but-not-quite-an-unfaithful-mirror-that-reduces-feelings-of-ownership-and-agency
#14
Noreen O'Sullivan, Christophe de Bezenac, Andrea Piovesan, Hannah Cutler, Rhiannon Corcoran, David Fenyvesi, Marco Bertamini
The experience of seeing one's own face in a mirror is a common experience in daily life. Visual feedback from a mirror is linked to a sense of identity. We developed a procedure that allowed individuals to watch their own face, as in a normal mirror, or with specific distortions (lag) for active movement or passive touch. By distorting visual feedback while the face is being observed on a screen, we document an illusion of reduced embodiment. Participants made mouth movements, while their forehead was touched with a pen...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/29160099/safety-of-intradiaphragmatic-delivery-of-adeno-associated-virus-mediated-alpha-glucosidase-raav1-cmv-hgaa-gene-therapy-in-children-affected-by-pompe-disease
#15
Manuela Corti, Cristina Liberati, Barbara K Smith, Lee Ann Lawson, Ibrahim S Tuna, Thomas J Conlon, Kirsten E Erger, Saleem Islam, Roland Herzog, David D Fuller, Shelley Collins, Barry J Byrne
We conducted a first in human trial of diaphragmatic gene therapy (AAV1-CMV-GAA) to treat respiratory and neural dysfunction in early-onset Pompe disease. The primary objective of this study was to assess the safety of rAAV1-CMV-hGAA vector delivered to the diaphragm muscle of Pompe disease subjects with ventilatory insufficiency. Safety was assessed by measurement of change in serum chemistries and hematology, urinalysis, and immune response to GAA and AAV as well as change in level of health. Our data demonstrate that the AAV treatment was safe and there were no adverse events related to the study agent...
November 21, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29159551/long-term-over-10%C3%A2-years-retrospective-follow-up-of-laparoscopic-adjustable-gastric-banding
#16
Dvir Froylich, Tamar Abramovich-Segal, Guy Pascal, Ivy Haskins, Boaz Appel, Naama Kafry, David Hazzan
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) placements have progressively decreased in recent years. This is related to poor long-term weight loss outcomes and necessity for revision or removal of these bands. Long-term outcome results following LAGB are limited. The aim of our study was to determine the long-term outcome after LAGB at our institution. OBJECTIVES: The aim of our study was to determine the long-term outcome after LAGB at our institution...
October 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29159423/characterizing-pediatric-surgical-capacity-in-the-eastern-democratic-republic-of-congo-results-of-a-pilot-study
#17
Sarah B Cairo, Luc Malemo Kalisya, Richard Bigabwa, David H Rothstein
PURPOSE: Characterize pediatric surgical capacity in the eastern Democratic Republic of Congo (DRC) to identify areas of potential improvement. METHODS: The Pediatric Personnel, Infrastructure, Procedures, Equipment, and Supplies (PediPIPES) survey was used in two representative eastern DRC provinces to assess existing surgical infrastructure and capacity. We compared our results to previously published reports from other sub-Saharan African countries. RESULTS: Fourteen hospitals in the eastern DRC and 37 in 19 sub-Saharan African (SSA) countries were compared...
November 20, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#18
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN(2+)) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
November 17, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29156176/management-of-patients-with-left-ventricular-assist-devices-requiring-teeth-extraction-is-halting-anticoagulation-appropriate
#19
Visakha Suresh, Muath Bishawi, Michael W Manning, Chetan Patel, Joseph Rogers, Carmelo Milano, Jacob Schroder, Mani Daneshmand, David Powers
PURPOSE: An increasing number of patients with end-stage heart failure are supported with left ventricular assist device (LVAD) implantation and must be maintained on a consistent anticoagulation regimen. Pre-emptive extraction of carious teeth in these patients is necessary to prevent seeding of the implanted device and endocarditis. Thus, the objective of this study was to evaluate bleeding complications after minor oral surgery, specifically teeth extractions, in this unique patient population requiring long-term anticoagulation...
October 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29156169/next-generation-minimal-resection-fixed-bearing-total-ankle-replacement-indications-and-outcomes
#20
REVIEW
Justin Tsai, David I Pedowitz
Total ankle arthroplasty is an increasingly popular procedure to address tibiotalar joint arthritis. Implant design and the rationale behind it have changed throughout the years. Newer generation implants allow for minimal resection of bone and use fixed-bearing technology. Long-term follow-up multicenter studies will determine the lifetime of these devices and their effectiveness in addressing pain and improving function for patients with endstage tibiotalar arthritis.
January 2018: Clinics in Podiatric Medicine and Surgery
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