Eunjeong Oh, Hahyeong Jang, Subin Ok, Jiwon Eom, Hyunyong Lee, Sung Hun Kim, Jong Hwa Kim, Yu Mi Jeong, Kyeong Jin Kim, Seung Pil Yun, Hyung-Jun Kwon, In-Chul Lee, Ji-Young Park, Siyoung Yang
Tagetes erecta and Ocimum basilicum are medicinal plants that exhibit anti-inflammatory effects against various diseases. However, their individual and combined effects on osteoarthritis (OA) are unknown. Herein, we aimed to demonstrate the effects of T. erecta, O. basilicum , and their mixture, WGA-M001, on OA pathogenesis. The administration of total extracts of T. erecta and O. basilicum reduced cartilage degradation and inflammation without causing cytotoxicity. Although WGA-M001 contained lower concentrations of the individual extracts, it strongly inhibited the expression of pathogenic factors...
December 14, 2023: International Journal of Molecular Sciences